title: Congenital Thrombophilia and Intracardiac Thrombosis: Probably an Underdiagnosed Event.
abstract: BACKGROUND
  To investigate the number of patients with congenital thrombophilia who presented an intracardiac thrombosis.
  
  
  METHODS
  Personal files were reevaluated together with a time-unlimited search of the literature.
  
  
  RESULTS
  Twenty-five patients with intracardiac thrombosis and congenital thrombophilia have been gathered from the literature including the two personal cases. The distribution observed in thrombophilia patients is similar for left side or right side heart (9 vs 11 cases). The left ventricle and the right ventricle were involved in six or five instances, respectively. In one case, both ventricles were involved. On the contrary, the left atrium was involved in three cases whereas the right atrium was affected in six cases. In the remaining cases, more than one heart chamber was involved.
  
  
  CONCLUSIONS
  In "normal" subjects, left side thromboses are predominant once catheter-associated thrombi are excluded. The reason of this discrepancy lies in the greater prothrombotic effect exercised by congenital thrombophilia on venous thrombosis compared to arterial thrombosis. The relative high prevalence of cardiac thrombosis seen in patients with antithrombin and protein C deficiencies indicated that a cardiac evaluation should be carried out in all patients with these two defects.
authors.affiliation: Department of Medicine, University of Padua, Medical School, Padua, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Girolami
authors.affiliation: Department of Medicine, University of Padua, Medical School, Padua, Italy.
authors.forename: Giulia Berti
authors.initials: GB
authors.lastname: de Marinis
authors.affiliation: Department of Medicine, University of Padua, Medical School, Padua, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Treleani
authors.affiliation: Department of Medicine, University of Padua, Medical School, Padua, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Tasinato
authors.affiliation: Division of General Medicine, Padua City Hospital, Padua, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Girolami
keywords: Antithrombin deficiency; Cardiac thrombosis; Protein C deficiency; Thrombophilia