title: Effects of experimental pastes containing surface pre-reacted glass ionomer fillers on inhibition of enamel demineralization.
abstract: This study aimed to evaluate the inhibitory effect of experimental pastes containing surface pre-reacted glass ionomer (S-PRG) fillers on enamel demineralization. Bovine blocks were treated twice a day for 4 days by 7 groups; experimental pastes containing 0-30 wt% S-PRG filler (S00, S01, S05, S10, and S30), deionized water (DW) as negative control, and NaF paste (MP) as positive control. The surfaces were demineralized by acetic acid for 3 days. Mineral loss (ML) was calculated by micro-computed X-ray tomography. The treated surface was finally investigated with scanning electron microscope (SEM) and micro-focused particle induced X-ray emission (micro-PIXE). S05, S10 and S30 demonstrated significantly lower ML than S00, S01 and DW (p<0.05). S10 showed the greatest inhibitory effect, which was significantly greater than MP. The S-PRG filler containing experimental pastes demonstrated a potential to inhibit enamel demineralization. Sr ion incorporation was confirmed on the enamel surface with the experimental pastes.
authors.affiliation: Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU).
authors.forename: Keiki
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU).|Department of Endodontics and Clinical Cariology, Tokyo Dental College.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Hamba
authors.affiliation: Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU).
authors.forename: Syozi
authors.initials: S
authors.lastname: Nakashima
authors.affiliation: Department of Restorative Dentistry, University of Washington School of Dentistry.
authors.forename: Alireza
authors.initials: A
authors.lastname: Sadr
authors.affiliation: Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU).
authors.forename: Toru
authors.initials: T
authors.lastname: Nikaido
authors.affiliation: National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Oikawa
authors.affiliation: Department of Advanced Biomaterials, Division of Oral Health Sciences, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU).
authors.forename: Motohiro
authors.initials: M
authors.lastname: Uo
authors.affiliation: Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU).
authors.forename: Junji
authors.initials: J
authors.lastname: Tagami
mesh_terms: D000818:Animals; D002417:Cattle; D003743:Dental Enamel; D009824:Ointments; D012969:Sodium Fluoride; D014100:Toothpastes
chemical_list: D009824:Ointments; D014100:Toothpastes; D012969:Sodium Fluoride
keywords: Demineralization; Enamel; Micro-CT; Micro-PIXE; S-PRG filler