title: Carborane Derivative Conjugated with Gold Nanoclusters for Targeted Cancer Cell Imaging.
abstract: Polyhedral borane derivatives have been utilized in the treatment of boron neuron capture therapy (BNCT) for brain glioma, and much attention has been paid to search excellent biocompatible boron-rich composites for effective cancer BNCT therapy. In this study, we have exploited the self-assembly of the gold nanoclusters with carborane amino derivatives (GNCs-CB) for the precise bioimaging of cancer cells and targeted delivery of this carborane compound to the tumors. Our observations demonstrate that the GNCs-CB can readily realize accurate tumor imaging and long-term accumulation in tumor sites by EPR effect and nanometer size effect, and thus efficiently implement tumor-targeting delivery of the carborane derivative and facilitate the real-time fluorescent visualization monitoring of the carborane targeted delivery process. This makes it possible to realize the accurate location of the tumor by the carborane derivative and reduce the damage to normal tissues in the process of boron neutron capture therapy through imaging guided treatment.
authors.affiliation: State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University , Nanjing, 210096, China.
authors.forename: Jianling
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University , Nanjing, 210096, China.
authors.forename: Leifeng
authors.initials: L
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University , Nanjing, 210096, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University , Nanjing, 210096, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
authors.affiliation: State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University , Nanjing, 210096, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210093, China.
authors.forename: Hong
authors.identifier: http://orcid.org/0000-0003-3993-0013
authors.initials: H
authors.lastname: Yan
authors.affiliation: A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences , 28 Vavilov Street, Moscow 119991, Russia.
authors.forename: Marina Yu
authors.initials: MY
authors.lastname: Stogniy
authors.affiliation: A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences , 28 Vavilov Street, Moscow 119991, Russia.
authors.forename: Igor B
authors.initials: IB
authors.lastname: Sivaev
authors.affiliation: A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences , 28 Vavilov Street, Moscow 119991, Russia.
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Bregadze
authors.affiliation: State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University , Nanjing, 210096, China.
authors.forename: Xuemei
authors.identifier: http://orcid.org/0000-0001-6882-7774
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry / Q000493:pharmacokinetics; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D058726:Nanoconjugates / Q000009:adverse effects / Q000737:chemistry*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D061848:Optical Imaging / Q000379:methods*
chemical_list: D001896:Boron Compounds; D005456:Fluorescent Dyes; D058726:Nanoconjugates; D006046:Gold