title: Enhancement of antimicrobial activity by liposomal oleic acid-loaded antibiotics for the treatment of multidrug-resistant Pseudomonas aeruginosa.
abstract: In this study, we examined the efficacy of liposomal oleic acid-based antibiotic formulations on 32 strains of multidrug-resistant Pseudomonas aeruginosa (MDRPa). The average size of liposomes were 93.12 ± 2.3 nm holding a negative zeta potential at -57.3 ± 0.89. Liposomal antibiotic formulations were tested against 32 MDRPa strains isolated from burn wounds and urine samples, which exhibited an MIC of ≤8 μg/mL, whereas MIC of free antibiotics ranged from 32 to >1024 μg/mL. The results clearly indicate that the liposomes composed of naturally occurring oleic acid, could be used therapeutically either alone or in combination with antibiotics to effectively treat P. aeruginosa infections.
authors.affiliation: a Faculty of Bioengineering , Sathyabama University , Chennai , India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Pushparaj Selvadoss
authors.affiliation: b Department of Biotechnology , Sathyabama University , Chennai , India.
authors.forename: Jayshree
authors.initials: J
authors.lastname: Nellore
authors.affiliation: c Department of Microbiology , Sathyabama University Dental College and Hospital , Chennai , India.
authors.forename: Malathy
authors.initials: M
authors.lastname: Balaraman Ravindrran
authors.affiliation: d Department of Microbiology , Sri Ramachandra University , Chennai , India.
authors.forename: Uma
authors.initials: U
authors.lastname: Sekar
authors.affiliation: b Department of Biotechnology , Sathyabama University , Chennai , India.
authors.forename: Jayakrishna
authors.initials: J
authors.lastname: Tippabathani
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D004339:Drug Compounding; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D008081:Liposomes / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D019301:Oleic Acid / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D008081:Liposomes; D019301:Oleic Acid
keywords: Liposomal antibiotics; P. aeruginosa; multidrug resistant; oleic acid