title: Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis.
abstract: OBJECTIVE
  The aim of this meta-analysis was to undertake a meta-analysis to evaluate the correlation between cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene rs221775 A>G single nucleotide polymorphism and the susceptibility of multiple sclerosis (MS) susceptibility.
  
  
  METHODS
  Published manuscripts about CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were searched in the computerized bibliographic searches of Pubmed Embase and China National Knowledge Infrastructure (CNKI). Potential studies were screened and data for 5025 MS patients and 4706 controls from 20 publications were included. The association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility were demonstrated by odds ratio (OR) and 95% confidence interval (95%CI).
  
  
  RESULTS
  The pooled results showed no significant association between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility for dominant genetic model [OR=1.02, 95%CI:0.90~1.05, (P=0.80)], homozygous genetic model [OR=0.85,95%CI:0.71 ~1.03,(P=0.10)] and recessive genetic model [OR=0.99,95% CI:0.89~1.10,(P=0.90)].
  
  
  CONCLUSIONS
  With current evidence, CTLA-4 gene rs221775A>G single nucleotide polymorphism had no association with the susceptibility of multiple sclerosis.
authors.affiliation: Neurology, Internal Medicine, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, Guangdong, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Haibing
authors.affiliation: Department of Neurology, Shenzhen People's Hospital, Jinan University, Luohu District, Shenzhen, Guangdong, PR China.
authors.forename: Cao
authors.initials: C
authors.lastname: Xu
authors.affiliation: Neurology, Internal Medicine, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, Guangdong, PR China.
authors.forename: Cai
authors.initials: C
authors.lastname: Jifu
authors.affiliation: Neurology, Internal Medicine, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, Guangdong, PR China.
authors.forename: Zeng
authors.initials: Z
authors.lastname: Wenshuang
authors.affiliation: Neurology, Internal Medicine, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, Guangdong, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Ling
authors.affiliation: Neurology, Internal Medicine, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, Guangdong, PR China.
authors.forename: Cui
authors.initials: C
authors.lastname: Yuzhen
authors.affiliation: Neurology, Internal Medicine, The University of Hong Kong-Shenzhen Hospital, Futian District, Shenzhen, Guangdong, PR China.
authors.forename: Hu
authors.initials: H
authors.lastname: Yanjun
keywords: CTLA-4 gene; Meta-analysis; Multiple sclerosis; Polymorphism; Susceptibility