title: An MRI study of the corpus callosum in monkeys: Developmental trajectories and effects of neonatal hippocampal and amygdala lesions.
abstract: This study provides the first characterization of early developmental trajectories of corpus callosum (CC) segments in rhesus macaques using noninvasive MRI techniques and assesses long-term effects of neonatal amygdala or hippocampal lesions on CC morphometry. In Experiment 1, 10 monkeys (5 males) were scanned at 1 week-2 years of age; eight additional infants (4 males) were scanned once at 1-4 weeks of age. The first 8 months showed marked growth across all segments, with sustained, albeit slower, growth through 24 months. Males and females had comparable patterns of CC maturation overall, but exhibited slight differences in the anterior and posterior segments, with greater increases in the isthmus for males and greater increases in the rostrum for females. The developmental changes are likely a consequence of varying degrees of axonal myelination, redirection, and pruning. In Experiment 2, animals with neonatal lesions of the amygdala (n = 6; 3 males) or hippocampus (n = 6; 4 males) were scanned at 1.5 years post-surgery and compared to scans of six control animals from Experiment 1. Whereas amygdala damage yielded larger rostral and posterior body segments, hippocampal damage yielded larger rostrum and isthmus. These differences demonstrate that early perturbations to one medial temporal lobe structure may produce extensive and long-lasting repercussions in other brain areas. The current findings emphasize the complexity of neural circuitry putatively subserving neurodevelopmental disorders such as autism spectrum disorder and Williams syndrome, which are each characterized by malformations and dysfunction of complex neural networks that include regions of the medial temporal lobe.
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia.
authors.forename: Christa
authors.identifier: 0000-0002-6281-1269
authors.initials: C
authors.lastname: Payne
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Cirilli
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia.
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Bachevalier
mesh_terms: D000679:Amygdala / Q000473:pathology*; D000818:Animals; D000831:Animals, Newborn; D003337:Corpus Callosum / Q000000981:diagnostic imaging* / Q000254:growth & development*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male
keywords: Macaca mulatta; commissure; neurodevelopment; neuroimaging; nonhuman primate; rhesus macaque; structural; volumetric