title: Systematic review and meta-analysis of venous thromboembolism in otolaryngology-head and neck surgery.
abstract: The purpose of this study was to present our systematic review and meta-analysis of the data on venous thromboembolism (VTE; deep venous thrombosis [DVT] and/or pulmonary embolism [PE]) in otolaryngology-head and neck surgery (OHNS).
  
  
  
  PubMed and Scopus databases were searched for studies reporting VTE in OHNS. Incidence of VTE and bleeding is reported and meta-analyzed overall and for chemoprophylaxis and squamous cell carcinoma (SCC)/free flap subgroups.
  
  
  
  A total of 23 studies were included with a total of 618,264 patients. Incidence of VTE was 0.4%. The incidence of bleeding complications was 0.9%. The addition of chemoprophylaxis did not result in a decreased VTE incidence (odds ratio [OR], 0.86), but produced an increased risk of bleeding (OR, 3.78). The overall OR for VTE in SCC/free flap cases was 6.28.
  
  
  
  Chemoprophylaxis may not be necessary in the OHNS non-SCC or free flap patient population and must be balanced against an increased risk of bleeding. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1249-1258, 2017.
authors.affiliation: Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
authors.forename: Sami P
authors.identifier: 0000-0002-6835-2155
authors.initials: SP
authors.lastname: Moubayed
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Antoine
authors.identifier: 0000-0003-4326-1393
authors.initials: A
authors.lastname: Eskander
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
authors.forename: Moustafa W
authors.initials: MW
authors.lastname: Mourad
authors.affiliation: Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
authors.forename: Sam P
authors.initials: SP
authors.lastname: Most
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D015994:Incidence; D008297:Male; D010038:Otorhinolaryngologic Diseases / Q000473:pathology / Q000601:surgery; D010039:Otorhinolaryngologic Neoplasms / Q000175:diagnosis / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D011655:Pulmonary Embolism / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D018570:Risk Assessment; D016019:Survival Analysis; D054556:Venous Thromboembolism / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology
keywords: otolaryngology; thromboembolic; thromboembolism; thromboprophylaxis; thrombosis