title: Design and evaluation of surface functionalized superparamagneto-plasmonic nanoparticles for cancer therapeutics.
abstract: Designing a multifunctional nanomaterial is always considered as a biggest concern in the field of nanomedicine which aims to promote versatile action in a single use from tracking to therapeutics. Therefore, metallic nanoparticles are well exploited as a major platform with the assemblage of surface modifications which can be effectively engaged for plenty of applications. Here, in this work, we have successfully amalgamated gold coated magnetite core-shell nanoparticles along with bio-functionalization of folic acid and doxorubicin to explore its possibility as a distinct nanocargo for cancer nanotheranostics. This unique combination of both magnetic and optical properties makes its function to be more precise. For example, in case of in-vitro drug-release studies more than 75% of drug moieties are released at acidic pH 5.4 and exactly fitting in first order rate kinetics. As gold shell retains the superparamagnetic nature of the core it exhibited high r2values, and because of large relaxivities (r2/r1) ratio, they are confirmed as T2-weighted contrast agent by MRI. Finally, under microwave of 2.45GHz exhibited enough heat which can induce both apoptosis & necrosis leading to cell death. Thus, we conclude that our nanoparticle can be a multitool for diagnosis and therapeutics for various human diseases.
authors.affiliation: Program on Nanoscience and Nanotechnology, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Ravichandran
authors.affiliation: Department of Genetics and Molecular Biology, Mexico.
authors.forename: Goldie
authors.initials: G
authors.lastname: Oza
authors.affiliation: Program on Nanoscience and Nanotechnology, Mexico; Department of Electrical Engineering, Mexico. Electronic address: velu@cinvestav.mx.
authors.forename: S
authors.initials: S
authors.lastname: Velumani
authors.affiliation: Department of Genetics and Molecular Biology, Mexico. Electronic address: jtapia@cinvestav.mx.
authors.forename: Jose Tapia
authors.initials: JT
authors.lastname: Ramirez
authors.affiliation: Department of Electrical Engineering - Bioelectronics Section, CINVESTAV-IPN, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Vera
authors.affiliation: Department of Electrical Engineering - Bioelectronics Section, CINVESTAV-IPN, Av. 2508 National Polytechnic Institute, Gustavo A. Madero, San Pedro Zacatenco, 07360 Mexico City, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Leija
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D004317:Doxorubicin; D005492:Folic Acid
keywords: Biocompatible; Core-shell; Drug kinetics; Hyperthermia; Multifunctional