title: A new α-pyrone from the deep-sea actinomycete Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111(T).
abstract: A new α-pyrone, nocapyrone S (1), together with five known compounds (2-6), were isolated from the deep-sea actinomycete Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111(T). Their structures were determined by spectroscopic analyses. The absolute configuration of 1 was established by quantum approaches. Cytotoxic activity of 1 was evaluated against K562, MCF-7, SGC7901, A375, Hela, and HepG2 cell lines.
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.|b College of Pharmacy, Jinan University , Guangzhou 510632 , China.
authors.forename: Ge
authors.initials: G
authors.lastname: Zou
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Liao
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Peng
authors.affiliation: b College of Pharmacy, Jinan University , Guangzhou 510632 , China.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Fang-Ying
authors.initials: FY
authors.lastname: Wei
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Zheng-Xiong
authors.initials: ZX
authors.lastname: Xu
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
authors.forename: Bing-Xin
authors.initials: BX
authors.lastname: Zhao
authors.affiliation: a Department of Chemistry , Jinan University , Guangzhou 510632 , China.|b College of Pharmacy, Jinan University , Guangzhou 510632 , China.
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xu
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020014:K562 Cells; D061986:MCF-7 Cells; D008386:Marine Biology; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011753:Pyrones; C000625247:nocapyrone S
keywords: Nocardiopsis dassonvillei; deep-sea actinomycete; α-pyrone