title: The genetic basis of obesity complications.
abstract: Intensive research is currently being performed into the genetic background of excess body mass compli- cations such as diabetes, cardiovascular disorders, especially atherosclerosis and coronary heart disease. Chronic inflammation is an important process in the pathogenesis of obesity, wherein there is an aberrant ex- pression of genes encoding adipokines. Visceral tissue is characterized by a higher expression and secretion of interleukin-8, interleukin-1ß and plasminogen activator inhibitor 1 in the subcutaneous tissue secretion of leptin prevails. An important complication of obesity is obstructive sleep apnea, often observed in Prader- Willi syndrome. The genetic background of sleep apnea may be a polymorphism of the SREBF1 gene. The consequence of excess body mass is metabolic syndrome, which may be related to the occurrence of the rs926198 variant of gene encoding caveolin-1. The genes of transcription factor TCF7L2 and PPAR-γ2 take part in the pathogenesis of diabetes development. It has been demonstrated that oncogenes FOS, FOSB, and JUN may be co-responsible not only for obesity but also for osteoporosis and colorectal cancer. It has been shown that weight loss causes a modification in the expression of about 100 genes involvedt in the production of substances such as cytokines and other responsible for chronic inflammation in obesity. In future studies on the complications of obesity, such scientific disciplines as proteomics, peptidomics, metabolomics and transcriptomics should be used. The aim of this study is to present the current state of knowledge about the genetic basis of obesity complications.
authors.affiliation: Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Skrypnik
authors.affiliation: Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Suliburska
authors.affiliation: Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznań University of Medical Sciences, Poland.
authors.forename: Damian
authors.initials: D
authors.lastname: Skrypnik
authors.affiliation: Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznań University of Medical Sciences, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Pilarski
authors.affiliation: Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poland.
authors.forename: Julita
authors.initials: J
authors.lastname: Reguła
authors.affiliation: Department of Education and Obesity Treatment and Metabolic Disorders, Poznań University of Medical Sciences, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Bogdański
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000235:genetics*; D050152:Intra-Abdominal Fat / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D024821:Metabolic Syndrome / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology; D009765:Obesity / Q000150:complications* / Q000235:genetics*; D009857:Oncogenes; D047495:PPAR gamma / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000453:epidemiology; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D050151:Subcutaneous Fat / Q000378:metabolism; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics
chemical_list: D052242:Adiponectin; D020738:Leptin; D047495:PPAR gamma; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein
keywords: genetic background; obesity; obesity complications