title: First report of human parechovirus type 3 infection in a pregnant woman.
abstract: Human parechovirus type 3 (HPeV3) can cause serious conditions in neonates, such as sepsis and encephalitis, but data for adults are lacking. The case of a pregnant woman with HPeV3 infection is reported herein. A 28-year-old woman at 36 weeks of pregnancy was admitted because of myalgia and muscle weakness. Her grip strength was 6.0kg for her right hand and 2.5kg for her left hand. The patient's symptoms, probably due to fasciitis and not myositis, improved gradually with conservative treatment, however labor pains with genital bleeding developed unexpectedly 3 days after admission. An obstetric consultation was obtained and a cesarean section was performed, with no complications. A real-time PCR assay for the detection of viral genomic ribonucleic acid against HPeV showed positive results for pharyngeal swabs, feces, and blood, and negative results for the placenta, umbilical cord, umbilical cord blood, amniotic fluid, and breast milk. The HPeV3 was genotyped by sequencing of the VP1 region. The woman made a full recovery and was discharged with her infant in a stable condition.
authors.affiliation: Department of Neurology, Matsushita Memorial Hospital, Osaka, Japan. Electronic address: makiko-t@koto.kpu-m.ac.jp.
authors.forename: Makiko
authors.initials: M
authors.lastname: Shinomoto
authors.affiliation: Department of General Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kawasaki
authors.affiliation: Department of Obstetrics and Gynecology, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Sugahara
authors.affiliation: Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Nakata
authors.affiliation: Department of General Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kotani
authors.affiliation: Department of General Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Yoshitake
authors.affiliation: Department of General Internal Medicine, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Kento
authors.initials: K
authors.lastname: Yuasa
authors.affiliation: Department of Neurology, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Saeki
authors.affiliation: Department of Neurology, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
mesh_terms: D000328:Adult; D005260:Female; D005334:Fever; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D063806:Myalgia; D030061:Parechovirus / Q000235:genetics / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000000981:diagnostic imaging* / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000000981:diagnostic imaging* / Q000821:virology; D060888:Real-Time Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
keywords: Adult; Muscle weakness; Myalgia; Parechovirus type 3; Pregnancy