title: Validation of a new multiscale finite element analysis approach at the distal radius.
abstract: High-resolution peripheral computed tomography is commonly used to evaluate mechanical behavior of the distal radius microstructure using micro-finite element (FE) modeling. However, only a 9mm section is considered and boundary conditions (BCs) are usually simplified (platen-compression), and may not represent physiologic loading. Regardless, these methods are increasingly being used for clinical evaluations. Our goal was to develop and validate a novel multiscale solution that allows for physiologically relevant loading simulations (such as bracing during a fall), and show that mechanical behavior in the distal radius is different under platen BCs. Our approach incorporated bone microstructure together with organ-level radius geometry, by replacing matching continuum regions with micro-FE sections in user-defined regions of interest. Multiscale model predicted strains showed a strong correlation and a significant relationship with measured strains (r=0.836, p<0.001; slope=0.881, intercept=-12.17 µε, p<0.001). Interestingly, platen BC simulated strains were almost 50% lower than measured strains (r=0.835, p<0.001), and strain distributions were clearly different. Our multiscale method demonstrated excellent potential as a computationally efficient alternative for observing true mechanical environment within distal radius microstructure under physiologically accurate loading.
authors.affiliation: Worcester Polytechnic Institute, Department of Biomedical Engineering, 100 Institute Road, Worcester, MA 01609, Unites States of America. Electronic address: jejohnson@wpi.edu.
authors.forename: Joshua E
authors.initials: JE
authors.lastname: Johnson
authors.affiliation: Worcester Polytechnic Institute, Department of Biomedical Engineering, 100 Institute Road, Worcester, MA 01609, Unites States of America. Electronic address: ktroy@wpi.edu.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Troy
mesh_terms: D000328:Adult; D000368:Aged; D001696:Biomechanical Phenomena; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008422:Materials Testing; D055595:Mechanical Phenomena; D008875:Middle Aged; D011884:Radius
keywords: Continuum finite element; High-resolution peripheral computed tomography; Micro-finite element; Microstructure; Multiscale