title: Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome.
abstract: BACKGROUND
  Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play a vital role in ACS development; however, whether epigenetic modulation contributes to the regulation of blood immune cells in this disease has not been investigated.
  
  
  OBJECTIVE
  We conducted an epigenome-wide analysis with circulating immune cells to identify differentially methylated genes in ACS.
  
  
  RESULTS
  We examined genome-wide methylation of whole blood in 102 ACS patients and 101 controls using HumanMethylation450 array, and externally replicated significant discoveries in 100 patients and 102 controls. For the replicated loci, we further analyzed their association with ACS in 6 purified leukocyte subsets, their correlation with the expressions of annotated genes, and their association with cardiovascular traits/risk factors. We found novel and reproducible association of ACS with blood methylation at 47 cytosine-phosphoguanine sites (discovery: false discovery rate <0.005; replication: Bonferroni correctedP<0.05). The association of methylation levels at these cytosine-phosphoguanine sites with ACS was further validated in at least 1 of the 6 leukocyte subsets, with predominant contributions from CD8+T cells, CD4+T cells, and B cells. Blood methylation of 26 replicated cytosine-phosphoguanine sites showed significant correlation with expressions of annotated genes (includingIL6R,FASLG, andCCL18;P<5.9×10-4), and differential gene expression in case versus controls corroborated the observed differential methylation. The replicated loci suggested a role in ACS-relevant functions including chemotaxis, coronary thrombosis, and T-cell-mediated cytotoxicity. Functional analysis using the top ACS-associated methylation loci in purified T and B cells revealed vital pathways related to atherogenic signaling and adaptive immune response. Furthermore, we observed a significant enrichment of the replicated cytosine-phosphoguanine sites associated with smoking and low-density lipoprotein cholesterol (Penrichment≤1×10-5).
  
  
  CONCLUSIONS
  Our study identified novel blood methylation alterations associated with ACS and provided potential clinical biomarkers and therapeutic targets. Our results may suggest that immune signaling and cellular functions might be regulated at an epigenetic level in ACS.
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhu
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Kuai
authors.initials: K
authors.lastname: Yu
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Haijing
authors.initials: H
authors.lastname: Jiang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Siyun
authors.initials: S
authors.lastname: Deng
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Longxian
authors.initials: L
authors.lastname: Cheng
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Xuezhen
authors.initials: X
authors.lastname: Liu
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Jia
authors.initials: J
authors.lastname: Zhong
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Meian
authors.initials: M
authors.lastname: He
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Weihong
authors.initials: W
authors.lastname: Chen
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Ming
authors.initials: M
authors.lastname: Gao
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Yansen
authors.initials: Y
authors.lastname: Bai
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Luo
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Wenhua
authors.initials: W
authors.lastname: Mei
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: He
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Shunchang
authors.initials: S
authors.lastname: Sun
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Liyun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Hesong
authors.initials: H
authors.lastname: Zeng
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Huizhen
authors.initials: H
authors.lastname: Sun
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Chuanyao
authors.initials: C
authors.lastname: Liu
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Guo
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Jinyan
authors.initials: J
authors.lastname: Huang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: An
authors.initials: A
authors.lastname: Pan
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Yu
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Francesca
authors.initials: F
authors.lastname: Angileri
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Bingxia
authors.initials: B
authors.lastname: Ming
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Fang
authors.initials: F
authors.lastname: Zheng
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Qiutang
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Mao
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Yudong
authors.initials: Y
authors.lastname: Peng
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Yi
authors.initials: Y
authors.lastname: Mao
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Qing K
authors.initials: QK
authors.lastname: Wang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.).
authors.forename: Liming
authors.initials: L
authors.lastname: Liang
authors.affiliation: From the Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (J.L., X. Zhu, K.Y., H.J., Y.Z., S.D., X. Liu, X. Zhang, M.H., W.C., J.Y., Y.B., X. Han, B.L., X. He, H.S., C.L., Y.G., B.Z., Z.Z., A.P., Y.Y., F.A., T.W.); Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (J.L., L.Q., F.B.H.); Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (L.C., Q.Z., X.M., Y.P., Y.M.); Environmental Health Science, Columbia University Mailman School of Public Health, New York, NY (J.Z.); Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.G., B.M., F.Z.); Department of Cardiology, People's Hospital of Zhuhai, Guangdong, China (X. Luo, W.M.); Department of Cardiology, Bao'an Hospital, Shenzhen, Guangdong, China (S.S.); Department of Cardiology, Wuhan Central Hospital, Wuhan, Hubei, China (L.Z., P.H.); Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (H.Z.); Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (J.H., L.L.); and Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, China (Q.K.W.). wut@mails.tjmu.edu.cn lliang@hsph.harvard.edu.
authors.forename: Tangchun
authors.initials: T
authors.lastname: Wu
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D019175:DNA Methylation / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D005260:Female; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: DNA methylation; acute coronary syndrome; coronary artery disease; epigenomics; gene expression regulation; leukocytes; smoking