title: Novel Crossing System for the Recanalization of Complex Chronic Total Occlusions: Ex vivo Proof of Concept of the SoundBite Crossing System.
abstract: Chronic total occlusion (CTO) lesions are frequent in patients with peripheral and coronary artery disease, and associated with a higher risk of adverse events, including mortality, decreased quality of life, and increased health-care costs. Percutaneous intervention of CTO lesions has been associated with a lower procedural success rate, and current dedicated CTO devices may be of limited use for the non-CTO expert, and associated with increased intraprocedural complication rates. The SoundBite Crossing System (SoundBite Medical Solutions, Inc) is a newly developed device using shockwaves (short-duration, high-amplitude pressure pulses) to facilitate penetration of the proximal cap and crossing of the occlusion. The current report describes the first use of the SoundBite Crossing System in the recanalization of human ex vivo occluded arteries below the knee during a simulated procedure performed under fluoroscopy. Microcomputed tomography and histologic evaluation of the occluded and recanalized segment are provided to support therapeutic mechanism.
authors.affiliation: Université de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, Québec, Canada, J1H 5N4. simon.berube@usherbrooke.ca.
authors.forename: Simon
authors.initials: S
authors.lastname: Bérubé
authors.forename: Andrew
authors.initials: A
authors.lastname: Benko
authors.forename: Marc-Antoine
authors.initials: MA
authors.lastname: Despatis
authors.forename: Louis-Philippe
authors.initials: LP
authors.lastname: Riel
authors.forename: Marianne
authors.initials: M
authors.lastname: Brodmann
authors.forename: Eric
authors.initials: E
authors.lastname: Therasse
authors.forename: Martin
authors.initials: M
authors.lastname: Brouillette
authors.forename: Jihad A
authors.initials: JA
authors.lastname: Mustapha
authors.forename: Philippe
authors.initials: P
authors.lastname: Généreux
mesh_terms: D000369:Aged, 80 and over; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000601:surgery*; D002908:Chronic Disease; D057510:Endovascular Procedures / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D005471:Fluoroscopy; D006801:Humans; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016909:Tibial Arteries; D055114:X-Ray Microtomography