title: Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission.
abstract: Objective:This study investigates whether impairments associated with persistent ADHD-impaired attention allocation (P3 amplitude), peripheral hypoarousal (skin conductance level [SCL]), and adjustment in preparatory state (contingent negative variation [CNV])-reflect enduring deficits unrelated to ADHD outcome or are markers of ADHD remission.Method:Young people with childhood ADHD (73 persisters and 18 remitters) and 144 controls were compared on neurophysiological measures during two conditions (baseline and fast-incentive) of a four-choice reaction time task.Results:ADHD remitters differed from persisters, and were indistinguishable from controls, on baseline P3 amplitude and fast-incentive CNV amplitude (p≤ .05). ADHD remitters differed from controls (p≤ .01), and were indistinguishable from persisters (p> .05), on baseline SCL.Conclusion:Preparation-vigilance measures were markers of ADHD remission, confirming previous findings with other measures. Yet, SCL-measured peripheral hypoarousal emerges as an enduring deficit unrelated to ADHD improvement. Future studies should explore potential compensatory mechanisms that enable efficient preparation-vigilance processes in ADHD remitters.
authors.affiliation: King's College London, UK.
authors.forename: Sarah-Naomi
authors.initials: SN
authors.lastname: James
authors.affiliation: King's College London, UK.|University of London, UK.
authors.forename: Celeste H M
authors.initials: CHM
authors.lastname: Cheung
authors.affiliation: King's College London, UK.
authors.forename: Anna-Sophie
authors.initials: AS
authors.lastname: Rommel
authors.affiliation: King's College London, UK.
authors.forename: Gráinne
authors.initials: G
authors.lastname: McLoughlin
authors.affiliation: Heidelberg University, Germany.|University of Zurich, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Brandeis
authors.affiliation: Heidelberg University, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Banaschewski
authors.affiliation: King's College London, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Asherson
authors.affiliation: King's College London, UK.
authors.forename: Jonna
authors.initials: J
authors.lastname: Kuntsi
mesh_terms: D000293:Adolescent; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity; D002648:Child; D003265:Contingent Negative Variation; D004569:Electroencephalography; D006801:Humans; D011930:Reaction Time; D014851:Wakefulness
keywords: ADHD; EEG; adolescents; arousal; remission