title: Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?
abstract: The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg-1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg-1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO3) and perchloric acid (HClO4) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.
authors.affiliation: Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Bulat
authors.affiliation: Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy.
authors.forename: Danijela
authors.initials: D
authors.lastname: Đukić-Ćosić
authors.affiliation: Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy.
authors.forename: Biljana
authors.initials: B
authors.lastname: Antonijević
authors.affiliation: Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Buha
authors.affiliation: Institute of Occupational Health, Faculty of Medicine.
authors.forename: Petar
authors.initials: P
authors.lastname: Bulat
authors.affiliation: University of Belgrade, Belgrade, Institute for Public Health Požarevac, Požarevac.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Pavlović
authors.affiliation: Department of Toxicology "Akademik Danilo Soldatović", Faculty of Pharmacy.
authors.forename: Vesna
authors.initials: V
authors.lastname: Matović
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D003300:Copper / Q000032:analysis*; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008274:Magnesium / Q000032:analysis*; D008297:Male; D011817:Rabbits; D015032:Zinc / Q000032:analysis*
chemical_list: D002104:Cadmium; D003300:Copper; D008274:Magnesium; D015032:Zinc
keywords: biometal ratio; biometals; blood; bones; copper; interactions; kidney; liver; magnesium