title: Respiratory Syncytial Virus Infection Rates with Limited Use of Palivizumab for Infants Born at 29 to 31+6/7 Weeks Gestational Age.
abstract: BACKGROUND
  Immunoprophylaxis with palivizumab can reduce respiratory syncytial virus (RSV) infections and hospitalizations. Criteria in British Columbia limit the use of palivizumab to infants born at 29 to 31+6/7 weeks gestational age, which differ from guidelines of the American Academy of Pediatrics (AAP) and the Canadian Paediatric Society (CPS).
  
  
  OBJECTIVE
  To determine whether the limited use of palivizumab affected the frequency of hospital visits by RSV-positive infants (termed "RSV-positive hospital visits") who received approval for palivizumab and those who met the AAP/CPS criteria but did not receive approval for palivizumab.
  
  
  METHODS
  Data sets were generated for the period May 1, 2008, to April 30, 2011, to identify infants with gestational age of 29 to 31+6/7 weeks who were born in or transferred to the Fraser Health authority, RSV-positive results for infants less than 12 months of age who had visited Fraser Health sites and BC Children's Hospital, and palivizumab approvals. Infants were matched across these 3 data sets through their personal health numbers.
  
  
  RESULTS
  The study included 359 infants born at 29 to 31+6/7 weeks, of whom 297 met the AAP/CPS criteria. However, only 46 of these 297 received approval for palivizumab according to the BC criteria. Sixteen (4.5%) of the 359 infants had RSV-positive hospital visits during the RSV season (November through March). Of the 46 infants who received approval for palivizumab, 2 (4.3%) had RSV-positive hospital visits, and of the 251 who met the AAP/CPS criteria but did not receive palivizumab approval, 14 (5.6%) had RSV-positive hospital visits. Of the 359 infants, 6 (1.7%) had RSV-positive results while admitted to the neonatal intensive care unit, and 10 (2.8%) tested positive for RSV during a subsequent hospital visit.
  
  
  CONCLUSIONS
  The frequency of RSV-positive hospital visits did not differ between infants who received and those who did not receive approval for palivizumab in the Fraser Health authority. Limited use of palivizumab for RSV prophylaxis led to reasonable rates of RSV-positive hospital visits in the study population.
authors.affiliation: , BScPharm, ACPR, is Coordinator, Clinical and Distribution Pharmacy Services, Neonatal and Pediatric Pharmacy, Surrey Memorial Hospital, Surrey, British Columbia.
authors.forename: Brandi
authors.initials: B
authors.lastname: Newby
authors.affiliation: , MD, FRCPC, is Staff Neonatologist with the Department of Neonatology, Surrey Memorial Hospital, Surrey, British Columbia. He is also Clinical Assistant Professor with the University of British Columbia, Vancouver, British Columbia.
authors.forename: Todd
authors.initials: T
authors.lastname: Sorokan
keywords: antibodies; anticorps; humanisés; humanized; infant; monoclonal; monoclonaux; nourrisson; premature; prématuré; respiratory syncytial viruses; virus respiratoire syncytial