title: Role of interleukin-6 and pentraxin 3 as an early marker in Peyronie's disease.
abstract: Inflammation is mechanistically involved in the development of Peyronie's disease (PD). The aim of this study is to assess the relevance of serum pentraxin 3 (PTX3) and interleukin-6 (IL-6) concentrations in PD. The study enrolled 40 patients with PD in the acute phase and 40 healthy controls. Plasma PTX3 and IL-6 concentrations were evaluated in 40 patients in the acute phase of PD and 40 healthy controls by enzyme-linked immunosorbent assay. Serum concentrations of both PTX3 and IL-6 were significantly higher in the PD patients than in the control group (p=0.001 and p=0.001, respectively). There was a significant correlation between concentration of PTX3 and painful erections. IL-6 concentrations were significantly higher in patients with erectile dysfunction. IL-6 and PTX3 levels showed no correlation with age, serum C-reactive protein, degree of curvature, and disease duration. IL-6 trans-signaling and PTX3 amplification at the site of inflammation could have a role in pathophysiological mechanisms of PD. Biological drugs may be used for treatment during the acute phase of the disease based on this mechanism.
authors.affiliation: Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey. Electronic address: ardatar@gmail.com.
authors.forename: Arda
authors.initials: A
authors.lastname: Atar
authors.affiliation: Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Alev
authors.initials: A
authors.lastname: Kural
authors.affiliation: Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Gurkan
authors.initials: G
authors.lastname: Yenice
authors.affiliation: Department of Urology, Canakkale Training and Research Hospital, Canakkale, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Comez
authors.affiliation: Department of Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Tugcu
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003710:Demography; D007172:Erectile Dysfunction / Q000097:blood / Q000503:physiopathology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000502:physiology; D010411:Penile Induration / Q000097:blood* / Q000503:physiopathology; D012372:ROC Curve; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D015850:Interleukin-6; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C508600:IL6 protein, human
keywords: Cytokine; Fibrosis; Peyronie’s disease