title: It Takes a Village to Unmask HSTL.
abstract: <b/> In this issue ofCancer Discovery, McKinney and colleagues describe the genetics of hepatosplenic T-cell lymphoma, a rare subtype of T-cell lymphoma with unique clinical characteristics. The findings, specifically frequent mutations ofSTAT5B,PIK3CD, and the histone methyltransferaseSETD2, may help guide translational efforts to target this deadly disease.Cancer Discov; 7(4); 352-3. ©2017 AACR.See related article by McKinney et al., p. 369.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yoshida
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. dweinstock@partners.org.|Broad Institute of MIT and Harvard University, Cambridge, Massachusetts.
authors.forename: David M
authors.initials: DM
authors.lastname: Weinstock
mesh_terms: D000818:Animals; D001483:Base Sequence / Q000235:genetics; D058534:Class I Phosphatidylinositol 3-Kinases / Q000235:genetics*; D059472:Exome / Q000235:genetics; D015894:Genome, Human; D006529:Hepatomegaly / Q000150:complications / Q000235:genetics / Q000473:pathology; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications / Q000235:genetics* / Q000473:pathology; D051379:Mice; D050799:STAT5 Transcription Factor / Q000235:genetics*; D013163:Splenomegaly / Q000150:complications / Q000235:genetics / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
chemical_list: D050799:STAT5 Transcription Factor; C494095:STAT5B protein, human; D011495:Histone-Lysine N-Methyltransferase; C521636:SETD2 protein, human; D058534:Class I Phosphatidylinositol 3-Kinases; C486018:PIK3CD protein, human