title: [Autophagy in chronic liver diseases: a friend rather than a foe?]
abstract: Within recycling damaged cell components, autophagy maintains cell homeostasis. Thus, it has been anticipated that autophagy would play an essential role in the pathogenesis of chronic liver diseases. Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the most prevalent chronic liver diseases in Western countries, sharing common histopathologic features and a common disease progression. In this review, we discuss the role of autophagy at different stages of NAFLD and ALD as well as in liver regeneration and hepatocarcinogenesis.
authors.affiliation: Inserm, U1065, C3M, Team 8 "Hepatic complications in obesity", Nice, France - Université Nice Côte d'Azur, Inserm, C3M, Nice, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gual
authors.affiliation: Institut Cochin, Inserm, U1016, CNRS UMR 8104, université Paris-Descartes, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Gilgenkrantz
authors.affiliation: Inserm-U1149, CNRS-ERL8252, Centre de recherche sur l'inflammation, Paris, France - Sorbonne Paris Cité, Laboratoire d'excellence Inflamex, faculté de médecine, site Xavier Bichat, université Paris Diderot, Paris, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Lotersztajn
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D008107:Liver Diseases / Q000473:pathology* / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000473:pathology / Q000503:physiopathology; D065626:Non-alcoholic Fatty Liver Disease / Q000473:pathology / Q000503:physiopathology