title: Pathophysiology of GvHD and Other HSCT-Related Major Complications.
abstract: For over 60 years, hematopoietic stem cell transplantation has been the major curative therapy for several hematological and genetic disorders, but its efficacy is limited by the secondary disease called graft versus host disease (GvHD). Huge advances have been made in successful transplantation in order to improve patient quality of life, and yet, complete success is hard to achieve. This review assimilates recent updates on pathophysiology of GvHD, prophylaxis and treatment of GvHD-related complications, and advances in the potential treatment of GvHD.
authors.affiliation: Department of Internal Medicine III, University Medical Centre , Regensburg , Germany.
authors.forename: Sakhila
authors.initials: S
authors.lastname: Ghimire
authors.affiliation: Department of Internal Medicine III, University Medical Centre , Regensburg , Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Weber
authors.affiliation: Hematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle , UK.
authors.forename: Emily
authors.initials: E
authors.lastname: Mavin
authors.affiliation: Hematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle , UK.
authors.forename: Xiao Nong
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Hematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle , UK.
authors.forename: Anne Mary
authors.initials: AM
authors.lastname: Dickinson
authors.affiliation: Department of Internal Medicine III, University Medical Centre , Regensburg , Germany.
authors.forename: Ernst
authors.initials: E
authors.lastname: Holler
keywords: T cells; graft versus host disease; haematopoietic stem cell transplantation; pathophysiology; prophylaxis