title: Study of SMAD-Dependent Signal Pathway in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H1N1 Virus.
abstract: Early fibrosis of the visceral organs is one of the main complications of infection caused by influenza A virus. Structural manifestations and molecular regulators of the epithelialmesenchymal transformation as a possible mechanism of fibrosis progression were studied in mice infected with influenza A/H1N1 A/Tomsk/13/2010 virus. We found early fibrosis of the lungs against the background of minor changes in fibroblast count. However, enhanced expression of TGF-β and SMAD-2 by macrophages and alveolocytes attested to possible development of epithelial-mesenchymal transformation and its contribution to activation of fibrogenesis process in the lungs.
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia. shatskaya110@gmail.com.
authors.forename: E V
authors.initials: EV
authors.lastname: Shatskaya
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kovner
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Potapova
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Cherdantseva
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Shkurupy
authors.affiliation: Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Shestopalov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000378:metabolism* / Q000821:virology; D008168:Lung / Q000473:pathology / Q000821:virology; D008297:Male; D051379:Mice; D011658:Pulmonary Fibrosis / Q000378:metabolism* / Q000821:virology; D015398:Signal Transduction; D051785:Smad Proteins / Q000378:metabolism*
chemical_list: D051785:Smad Proteins
keywords: SMAD-2; epithelial-mesenchymal transformations; fibrosis; influenza A/H1N1 A/Tomsk/13/2010 virus; lungs