title: [Effects of dexamethasone on MRL/lpr mice with systemic lupus erythematosus complicated with cognitive dysfunction].
abstract: To evaluate the effects of dexamethasone on systemic lupus erythematosus complicated with cognitive dysfunction.  Methods: Ten wild type mice and 20 MRL/lpr mice were applied for the research. MRL/lpr mice were randomly assigned to a MRL/lpr group and a MRL/lpr + dexamethasone (1.5 mg/kg) group. Interleukin-6 (IL-6), IL-1β, and tumor necrosis factor alpha (TNF-α) in serum and hippocampus were detected. The protein phosphorylation levels of phosphoinositide 3-kinase (P-PI3K), protein kinase B (P-Akt), NF-kappa-B inhibitor alpha (P-IκBa) and nuclear transcription factor  kappa-B p65 (P-NF-κB p65) were detected by Western blot, the level of P-NF-κB p65 also was detected by immunohistochemistry.   Results: Treatment with dexamethasone (1.5 mg/kg) alleviated the cognitive dysfunction and decreased the levels of IL-6, IL-1β and TNF-α in serum and hippocampus, and reduced the levels of P-PI3K, P-Akt, P-IκBa and P-NF-κB p65 in hippocampus in MRL/lpr mice.  Conclusion: Dexamethasone may play a protective role in the cognitive function by decreasing the levels of TNF-α and IL-1β in the hippocampus of MRL/lpr lupus mice.
authors.affiliation: Department of Histology and Embryology, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Research Center, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.affiliation: Research Center, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shen
authors.affiliation: Research Center, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Jiangyan
authors.initials: J
authors.lastname: Li
authors.affiliation: Research Center, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zha
authors.affiliation: Research Center, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Research Center, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Hu
authors.affiliation: Research Center, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xi
authors.affiliation: Research Center, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Chang
authors.affiliation: Department of Rheumatology and Immunology, First Affiliated Hospital, Bengbu Medical College, Bengbu Anhui 233030, China.
authors.forename: Changhao
authors.initials: C
authors.lastname: Xie
mesh_terms: D000818:Animals; D060825:Cognitive Dysfunction / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D019463:Mice, Inbred MRL lpr; D000072000:NF-KappaB Inhibitor alpha / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011897:Random Allocation; D051996:Transcription Factor RelA / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D053583:Interleukin-1beta; D015850:Interleukin-6; C498144:Rela protein, mouse; D051996:Transcription Factor RelA; D014409:Tumor Necrosis Factor-alpha; D000072000:NF-KappaB Inhibitor alpha; D003907:Dexamethasone; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt