title: Amide proton transfer magnetic resonance imaging in detecting intracranial hemorrhage at different stages: a comparative study with susceptibility weighted imaging.
abstract: Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) technique based on the chemical exchange-dependent saturation transfer mechanism. The purpose of this study was to investigate the diagnostic performance of APT MRI in detecting intracranial hemorrhage (ICH) at hyperacute, acute and subacute stages by comparing with susceptibility weighted imaging (SWI). APT MRI and SWI were performed on 33 included patients with ICH by using a 3-T MRI unit. A two-sided Mann-Whitney U test was used to detect differences in APT-weighted (APTw) and SWI signal intensities of ICH at hyperacute, acute and subacute stages. Receiver operating characteristic analysis was used to assess the diagnostic utilities of APT MRI and SWI. Our results showed that APT MRI could detect ICH at hyperacute, acute and subacute stages. Therefore, APTw signal intensity may serve as a reliable, noninvasive imaging biomarker for detecting ICH at hyperacute, acute and subacute stages. Moreover, APT MRI could provide additional information for the ICH compared with SWI.
authors.affiliation: Department of Radiology, Zhengzhou University People's Hospital &Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Xiaoyue
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Radiology, Zhengzhou University People's Hospital &Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Cooperative Innovation Center of Internet Healthcare &School of Software and Applied Technology, Zhengzhou, Henan, China.
authors.forename: Yusong
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Hong
authors.affiliation: Department of Radiology, Zhengzhou University People's Hospital &Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Taiyuan
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Radiology, Zhengzhou University People's Hospital &Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Lun
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Radiology, Wayne State University, Detroit, Michigan, USA.
authors.forename: E Mark
authors.initials: EM
authors.lastname: Haacke
authors.affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiology, Zhengzhou University People's Hospital &Henan Provincial People's Hospital, Zhengzhou, Henan, China.
authors.forename: Meiyun
authors.initials: M
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000577:Amides / Q000737:chemistry*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons; D055815:Young Adult
chemical_list: D000577:Amides; D015415:Biomarkers; D011522:Protons