title: Supratentorial cavernous malformations adjacent to the corticospinal tract: surgical outcomes and predictive value of diffusion tensor imaging findings.
abstract: OBJECTIVE Diffusion tensor imaging (DTI) findings may facilitate clinical decision making in patients with supratentorial cavernous malformations adjacent to the corticospinal tract (CST-CMs). The objective of this study was to determine the predictive value of preoperative DTI findings for surgical outcomes in patients with CST-CMs. METHODS A prospectively maintained database of patients with CM referred to the authors' hospital between September 2012 and October 2015 was reviewed to identify all consecutive surgically treated patients with CST-CM. All patients had undergone sagittal T1-weighted anatomical imaging and DTI before surgery. Both DTI findings and clinical characteristics of the patients and lesions were analyzed with respect to surgery-related motor deficits. DTI findings included lesion-to-CST distance (LCD) and the alteration (i.e., deviation, interruption, or degeneration due to the CM) of CST on preoperative DTI images. Surgery-related motor deficits at 1 week and the last clinic visit (≥ 3 months) after surgery were defined as short-term and long-term deficits, respectively. Preoperative and final modified Rankin Scale scores were also analyzed to identify the surgical outcomes in these patients. RESULTS A total of 56 patients with 56 CST-CMs were included in this study. The mean LCD was 3.9 ± 3.2 mm, and alterations of the CST were detected in 20 (36.7%) patients. One week after surgery, 21 (37.5%) patients had short-term surgery-related motor deficits, but only 14 (25.0%) patients had long term deficits at the last clinical visit. The mean patient follow-up was 14.7 ± 10.1 months. The difference between preoperative and final modified Rankin Scale scores was not statistically significant (p = 0.490). Multivariate analysis showed that both short-term (p < 0.001) and long-term (p = 0.002) surgery-related motor deficits were significantly associated with LCD. Receiver operating characteristic (ROC) curve results were as follows: for short-term surgery-related motor deficits, the area under the ROC curve (AUC) was 0.860, and the cutoff point was LCD = 2.55 mm; for long-term deficits, the AUC was 0.894, and the cutoff point was LCD = 2.30 mm. Both univariate (p = 0.012) and multivariate (p = 0.049) analyses revealed that CST alteration on preoperative DTI was significantly correlated with short-term surgery-related motor deficits. On univariate analysis, deep location of the CST-CMs was significantly correlated with long-term motor deficits (p = 0.016). Deep location of the CST-CMs had a trend toward significance with long-term motor deficits on the multivariate analysis (p = 0.060). CONCLUSIONS To facilitate clinical practice, the authors propose that 3.00 mm (2.55 to ∼3.00 mm) may be the safe LCD for surgery in patients with CST-CMs. A CST alteration on preoperative DTI and a deep location of the CST-CM may be risk factors for short- and long-term surgery-related motor deficits, respectively. A randomized controlled trial is needed to demonstrate the predictive value of preoperative DTI findings on surgical outcomes in patients with CST-CMs in future studies.
authors.affiliation: 1Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fujian Province.
authors.forename: Yuanxiang
authors.initials: Y
authors.lastname: Lin
authors.affiliation: 1Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fujian Province.
authors.forename: Fuxin
authors.initials: F
authors.lastname: Lin
authors.affiliation: 1Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fujian Province.
authors.forename: Dezhi
authors.initials: D
authors.lastname: Kang
authors.affiliation: 2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing.|3China National Clinical Research Center for Neurological Diseases, Beijing.|4Center of Stroke, Beijing Institute for Brain Disorders, Beijing; and.|5Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, People's Republic ofChina.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: 2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing.|3China National Clinical Research Center for Neurological Diseases, Beijing.|4Center of Stroke, Beijing Institute for Brain Disorders, Beijing; and.|5Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, People's Republic ofChina.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cao
authors.affiliation: 2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing.|3China National Clinical Research Center for Neurological Diseases, Beijing.|4Center of Stroke, Beijing Institute for Brain Disorders, Beijing; and.|5Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, People's Republic ofChina.
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D016208:Databases, Factual; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging* / Q000601:surgery*; D008297:Male; D009069:Movement Disorders / Q000453:epidemiology / Q000209:etiology; D019635:Neurosurgical Procedures / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging* / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: AUC = area under the ROC; AVM = arteriovenous malformation; CAO = the corridor formed by the CST, arcuate fasciculus, and optic radiation; CM = cavernous malformation; CST = cortical spinal tract; CST-CM = CM adjacent to the CST; DTI = diffusion tensor imaging; LCD = lesion-to-CST distance; ROC = receiver operating characteristic; aVDA = associated developmental venous anomaly; cavernous malformations; corticospinal tract; diffusion tensor imaging; mRS = modified Rankin Scale; risk factor; surgery; vascular disorders