title: Urinary Lactate Dehydrogenase Activity and Its Isozyme Patterns in Kawasaki Disease.
abstract: Abnormal urinary findings, such as sterile pyuria, proteinuria, and microscopic hematuria, are often seen in the acute phase of Kawasaki disease (KD). We investigated the potential significance of urinary lactate dehydrogenase (U-LDH) activity and its isozyme patterns in KD. Total U-LDH activity and its isozymes (U-LDH1-5) levels were compared among 120 patients with KD, 18 patients with viral infection (VI), and 43 patients with upper urinary tract infection (UTI) and additionally compared between intravenous immunoglobulin (IVIG) responders (n= 89) and nonresponders (n= 31) with KD. Total U-LDH activity was higher in KD (35.4 ± 4.8 IU/L,P< 0.05) and UTI patients (66.0 ± 8.0 IU/L,P< 0.01) than in VI patients (17.0 ± 6.2 IU/L). In the isozyme pattern analysis, KD patients had high levels of U-LDH1 and U-LDH2, while UTI patients had high levels of U-LDH3, U-LDH4, and U-LDH5. Furthermore, IVIG nonresponders of KD had significantly higher levels of total U-LDH activity (45.1 ± 4.7 IU/L,P< 0.05), especially U-LDH1 and U-LDH2 (P< 0.05), than IVIG responders (32.0 ± 2.8 IU/L). KD patients have increased levels of total U-LDH activity, especially U-LDH-1 and U-LDH2, indicating a unique pattern of U-LDH isozymes different from that in UTI patients.
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kawamura
authors.affiliation: Division of Nursing, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Seiichiro
authors.identifier: 0000-0001-8016-2330
authors.initials: S
authors.lastname: Takeshita
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanai
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan; Department of Pediatrics, Japan Self-Defense Forces Central Hospital, Setagaya, Tokyo, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Takizawa
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Tsujita
authors.affiliation: Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Nonoyama