title: CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM.
abstract: BACKGROUND
  In this study, we investigated the relationship of adiponectin with bone marker changes in Egyptian children and adolescents with T1DM and the effect of disease duration on these markers, as well as the possible correlations between adiponectin and bone markers in these patients.
  
  
  METHODS
  Sixty Egyptian children and adolescent patients with T1DM were studied. Serum adiponectin and collagen breakdown products (cross-linked C-terminal telopeptide of collagen type l »CTX«) were measured and compared to the results of 20 age-matched healthy controls.
  
  
  RESULTS
  After adjustment for age, BMI, Tanner stage and gender; (total) adiponectin was significantly higher in all T1DM patients. Serum level of CTX and 25(OH)D showed a marked decrease in diabetics with disease duration > 5 years. Serum level of (total) calcium and inorganic phosphorus (Pi) did not show significant difference from control. CTX was inversely correlated to FBG and T1DM duration. Piwas inversely, while 25(OH)D was directly correlated to FBG. Total calcium showed an inverse correlation with HbA1c. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM.
  
  
  CONCLUSIONS
  Adiponectin showed no correlation with either CTX or bone homeostatic indices. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM. We recommend further investigation of adiponectin isoforms in a population-based study, to establish a good age- and sex-related reference.
authors.affiliation: Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
authors.forename: Amel A
authors.initials: AA
authors.lastname: Hashim
authors.affiliation: Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
authors.forename: Sahar A
authors.initials: SA
authors.lastname: Ali
authors.affiliation: Biochemistry and Pediatric Departments, National Institute of Diabetes and Endocrinology (NIDE), Cairo, Egypt.
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Emara
authors.affiliation: Biochemistry and Pediatric Departments, National Institute of Diabetes and Endocrinology (NIDE), Cairo, Egypt.
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: El-Hefnawy
keywords: CTX; T1DM; adiponectin; bone biochemical markers; clinical