title: A brother and sister with breast cancer, BRCA2 mutations and bilateral supernumerary nipples.
abstract: We describe a 54-year-old man with breast cancer and a BRCA2 mutation who was also found to have bilateral supernumerary nipples. His sister, also with a BRCA2 mutation, was diagnosed with breast cancer in her late forties; she also had bilateral supernumerary nipples. We address the significance of breast cancer arising in breast tissue underlying supernumerary nipples; the known association between supernumerary nipples and genitourinary malignancies/malformations and the possible link between BRCA2 and supernumerary nipple development. We believe that this is the first described case of the latter. We then outline an approach to further management for supernumerary nipple cases.
authors.affiliation: University of Sydney, Department of Medicine, Camperdown, 2050 NSW, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: McKay
authors.affiliation: North Coast Cancer Institute, Lismore, 2480 NSW, Australia.
authors.forename: Ryan
authors.initials: R
authors.lastname: Coad
keywords: Supernumerary nipples; breast cancer; ectopic; familial; genitourinary malformations