title: Glioblastoma multiforme in conus medullaris with intracranial metastasis after postoperative adjuvant therapy.
abstract: Spinal glioblastoma multiforme is not common among spinal cord tumors. According to our literature review, only 27 cases originating from the conus medullaris were reported. We herein reported a case of a 10-year-old child diagnosed with glioblastoma multiforme. The patient received adjuvant radiotherapy and standard temozolomide chemotherapy after total excision. Intracranial lesions were found 1 month after postoperative adjuvant therapy. We described the clinical characteristics and postoperative therapy of the patient, and reviewed all of the published cases of conus medullaris glioblastoma. Location, age, leptomeningeal spread, and secondary hydrocephalus may be predictive factors. Immunohistochemical factors such as p53 and Ki-67 are also important. Combined treatment of surgery and postoperative adjuvant therapy is commonly used, but is controversial.
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dongcheng District, Beijing, P.R. China Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, MA Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dongcheng District, Beijing, P.R. China.
authors.forename: Chengrui
authors.initials: C
authors.lastname: Yan
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Kong
authors.forename: Hua
authors.initials: H
authors.lastname: Yin
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Huayu
authors.initials: H
authors.lastname: He
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Yongning
authors.initials: Y
authors.lastname: Li
authors.forename: Wenbin
authors.initials: W
authors.lastname: Ma
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D001932:Brain Neoplasms / Q000556:secondary*; D002648:Child; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013116:Spinal Cord / Q000000981:diagnostic imaging*; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy