title: Impact of Different Analytic Approaches on the Analysis of the Breast Fibroglandular Tissue Using Diffusion Weighted Imaging.
abstract: Purpose. This study investigated the impact of the different region of interest (ROI) approaches on measurement of apparent diffusion coefficient (ADC) values in the breast firbroglandular tissue (FT).Methods. Breast MR images of 38 women diagnosed with unilateral breast cancer were studied. Percent density (PD) and ADC were measured from the contralateral normal breast. Four different ROIs were used for ADC measurement. The measured PD and ADC were correlated.Results. Among the four ROIs, the manually placed small ROI on FT gave the highest mean ADC (ADC = 1839 ± 343 [×10-6mm2/s]), while measurement from the whole breast gave the lowest mean ADC (ADC = 933 ± 383 [×10-6mm2/s]). The ADC measured from the whole breast was highly correlated with PD withr= 0.95. In slice-to-slice comparison, the central slices with more FT had higher ADC values than the peripheral slices did, presumably due to less partial volume effect from fat.Conclusions. Our results indicated that the measured ADC heavily depends on the composition of breast tissue contained in the ROI used for the ADC measurements. Women with low breast density showing lower ADC values were most likely due to the partial volume effect of fatty tissues.
authors.affiliation: Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Yoon Jung
authors.initials: YJ
authors.lastname: Choi
authors.affiliation: Center for Functional Onco-Imaging, University of California, Irvine, CA, USA; Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan.
authors.forename: Jeon-Hor
authors.identifier: 0000-0003-4830-927X
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Center for Functional Onco-Imaging, University of California, Irvine, CA, USA.
authors.forename: Hon J
authors.initials: HJ
authors.lastname: Yu
authors.affiliation: Center for Functional Onco-Imaging, University of California, Irvine, CA, USA.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Center for Functional Onco-Imaging, University of California, Irvine, CA, USA.
authors.forename: Min-Ying
authors.identifier: 0000-0002-3069-0271
authors.initials: MY
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008875:Middle Aged