title: Guillain-Barre Syndrome in a Patient with Primary Extranodal Intestinal Non-Hodgkin's Lymphoma: Paraneoplastic, Drug Induced or Coincidental?
abstract: Neurological involvement is observed in 5%-25% of patients with lymphoma being either the first presentation of the disease or emerging during its course. However, Guillain-Barré syndrome is rarely reported. In this article, we present a case with intestinal lymphoma developing Guillain-Barré syndrome during the course of the disease. A 66-year-old male patient with primary extranodal intestinal lymphoma developed quadriparesis, sensory deficits and autonomic dysfunction while receiving chemotherapy. The findings of clinical, electrophysiological and laboratory examinations were consistent with Guillain-Barré syndrome. Guillain-Barré syndrome can potentially be fatal and mimic chemotherapy-induced neurotoxicity, especially in patients with lymphoma, and therefore, must be considered in the differential diagnosis.
authors.affiliation: İstanbul Bilim University Faculty of Medicine, Department of Neurology, İstanbul, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Kiyat Atamer
authors.affiliation: İstanbul Bilim University Faculty of Medicine, Department of Medical Oncology, İstanbul, Turkey.
authors.forename: Kerem
authors.initials: K
authors.lastname: Okutur
authors.affiliation: İstanbul University İstanbul Faculty of Medicine, Institute of Experimental Medicine, İstanbul, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
authors.affiliation: İstanbul Bilim University Faculty of Medicine, Department of Internal Medicine, İstanbul, Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Hasbal
authors.affiliation: Vehbi Koç Foundation American Hospital, Department of Neurology, İstanbul, Turkey.
authors.forename: Ari
authors.initials: A
authors.lastname: Boyaciyan
authors.affiliation: İstanbul Bilim University Faculty of Medicine, Department of Neurology, İstanbul, Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Krespi
authors.affiliation: İstanbul Bilim University Faculty of Medicine, Department of Medical Oncology, İstanbul, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Demir
keywords: Guillain-Barré syndrome; lymphoma; neurotoxicity; paraneoplastic syndrome; vincristine