title: Genetic variants inKCNJ11,TCF7L2andHNF4Aare associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study.
abstract: The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low-density lipoprotein (LDL), very LDL (VLDL), high-density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, includingKCNJ11, TCF7L2andHNF4A. TheKCNJ11SNP rs5210 was associated with T2DM, theTCF7L2SNP rs11196175 was associated with BMI and cholesterol and LDL levels, theTCF7L2SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and theHNF4ASNP rs1885088 was associated with LDL levels (P<0.05).
authors.affiliation: Department of Genetics, School of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Hugo Leonid
authors.initials: HL
authors.lastname: Gallardo-Blanco
authors.affiliation: Department of Endocrinology, University Hospital 'José Eleuterio González', Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Jesus Zacarías
authors.initials: JZ
authors.lastname: Villarreal-Perez
authors.affiliation: School of Nursing, Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Ricardo Martin
authors.initials: RM
authors.lastname: Cerda-Flores
authors.affiliation: Department of Computer Science, University of Texas Rio Grande Valley, TX 78539, USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Figueroa
authors.affiliation: Department of Biochemistry and Molecular Medicine, School of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Celia Nohemi
authors.initials: CN
authors.lastname: Sanchez-Dominguez
authors.affiliation: School of Nursing, Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Juana Mercedes
authors.initials: JM
authors.lastname: Gutierrez-Valverde
authors.affiliation: Department of Genetics, School of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Iris Carmen
authors.initials: IC
authors.lastname: Torres-Muñoz
authors.affiliation: Department of Endocrinology, University Hospital 'José Eleuterio González', Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Fernando Javier
authors.initials: FJ
authors.lastname: Lavalle-Gonzalez
authors.affiliation: School of Nursing, Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Esther Carlota
authors.initials: EC
authors.lastname: Gallegos-Cabriales
authors.affiliation: Department of Genetics, School of Medicine, Autonomous University of Nuevo León, Monterrey, Nuevo León, CP 64460, Mexico.
authors.forename: Laura Elia
authors.initials: LE
authors.lastname: Martinez-Garza
keywords: HNF4A; KCNJ11; TCF7L2; association; body mass index; cholesterol; high-density lipoprotein; linkage disequilibrium; low-density lipoprotein; type 2 diabetes