title: Randomized clinical trial of ridge preservation using porcine bone/cross-linked collagen vs. bovine bone/non-cross-linked collagen: cone beam computed tomographic analysis.
abstract: OBJECTIVE
  The aim of this study was to radiographically compare horizontal and vertical alterations of the alveolar ridge after ridge preservation using different combinations of biomaterials.
  
  
  METHODS
  The patients were randomly assigned into two groups: (a) the test group, which received collagenated porcine bone plus cross-linked collagen membrane (n = 15), and (b) the control group, which received collagenated bovine bone plus non-cross-linked collagen membrane (n = 15). Cone beam computed tomography (CBCT) was performed immediately after ridge preservation and 4 months thereafter to compare the horizontal and vertical alterations of the ridge. Intention-to-treat (ITT) and per protocol (PP) analyses were performed.
  
  
  RESULTS
  In both analyses, there was no statistically significant difference in the horizontal alteration of the alveolar ridge between the test and control groups: -1.3 ± 0.6 (ITT)/1.2 ± 0.5 (PP) vs. -1.5 ± 0.9 mm at the 1-mm level; -1.2 ± 0.7 (ITT and PP) vs. -1.2 ± 0.7 mm at the 3-mm level; and -0.9 ± 0.7 (ITT)/ -0.9 ± 0.7 (PP) vs. -0.9 ± 0.9 mm at the 5-mm level, whereas the vertical height in the midfacial area was significantly reduced in the test group compared with the control group: --1.1 ± 2.8 (ITT)/1.5 ± 3.0 (PP) vs. -0.7 ± 1.8 mm.
  
  
  CONCLUSIONS
  The horizontal ridge alteration in ridge preservation did not differ significantly between using the test the control groups, but the vertical ridge alteration was more pronounced when using the test group (KCT0001709).
authors.affiliation: Department of Periodontology, School of Dentistry, Kyung Hee University, Seoul, Korea.
authors.forename: Hyun-Chang
authors.initials: HC
authors.lastname: Lim
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors.forename: Ui-Won
authors.identifier: http://orcid.org/0000-0001-6371-4172
authors.initials: UW
authors.lastname: Jung
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors.forename: Hoon
authors.initials: H
authors.lastname: You
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors.forename: Jung-Seok
authors.identifier: http://orcid.org/0000-0003-1276-5978
authors.initials: JS
authors.lastname: Lee
mesh_terms: D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000539:Alveolar Process / Q000000981:diagnostic imaging*; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D003094:Collagen / Q000627:therapeutic use*; D054893:Cone-Beam Computed Tomography; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D064593:Heterografts; D006801:Humans; D011446:Prospective Studies; D016037:Single-Blind Method; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery
chemical_list: D003094:Collagen
keywords: bone substitutes; collagen; cone beam computed tomography; randomized controlled trial; tooth extraction