title: General and Stereoselective Method for the Synthesis of Sterically Congested and Structurally Diverse P-Stereogenic Secondary Phosphine Oxides.
abstract: A general and efficient method for the synthesis of bulky and structurally diverse P-stereogenic chiral secondary phosphine oxides (SPOs) by using readily available chiral amino alcohol templates is described. These chiral SPOs could be used as chiral building blocks for the synthesis of difficult-to-access bulky P-stereogenic phosphine compounds or ligands for organic catalysis.
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Zhengxu S
authors.identifier: 0000-0001-8386-1356
authors.initials: ZS
authors.lastname: Han
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Yibo
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Yongda
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Bo
authors.initials: B
authors.lastname: Qu
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Donald R
authors.initials: DR
authors.lastname: Caldwell
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Keith R
authors.identifier: 0000-0003-4875-3143
authors.initials: KR
authors.lastname: Fandrick
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Frank
authors.initials: F
authors.lastname: Roschangar
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Jinhua J
authors.initials: JJ
authors.lastname: Song
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. , 900 Old Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States.
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake