title: Synthesis, characterization and antibacterial activity of hybrid chitosan-cerium oxide nanoparticles: As a bionanomaterials.
abstract: The hybrid chitosan cerium oxide nanoparticles were prepared for the first time by green chemistry approach using plant leaf extract. The intense peak observed around 292nm in the UV-vis spectrum indicate the formation of cerium oxide nanoparticles. The XRD pattern revealed that the hybrid chitosan-cerium oxide nanoparticles have a polycrystalline structure with cubic fluorite phase. The FTIR spectrum of prepared samples showed the formation of Ce-O bonds and chitosan main chains COC and CO. The FESEM image of hybrid chitosan cerium oxide nanoparticles revealed that the particles are spherical in shape with grains size varying from 23.12nm to 89.91nm. EDAX analysis confirmed the presence of Ce, O, C and N elements in the prepared sample. TEM images showed that the prepared hybrid chitosan-cerium oxide nanoparticles are predominantly uniform in size and most of the particles are spherical in shape with less agglomeration and the particles size varies from 3.61nm to 24.40nm. The prepared chitosan cerium oxide nanoparticles of 50μL concentration showed good antibacterial properties against test pathogens, which was confirmed by the FESEM analysis. The prepared small particle size facilitate that these hybrid ChiCO2NPs could effectively be used in biomedical applications.
authors.affiliation: Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India.
authors.forename: R P
authors.initials: RP
authors.lastname: Senthilkumar
authors.affiliation: Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India. Electronic address: bhuvana_bt@yahoo.co.in.
authors.forename: V
authors.initials: V
authors.lastname: Bhuvaneshwari
authors.affiliation: Kirnd Institute of Research and Development, Tiruchirappalli, Tamilnadu, India.
authors.forename: R
authors.initials: R
authors.lastname: Ranjithkumar
authors.affiliation: Department of Biotechnology, Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Sathiyavimal
authors.affiliation: Departments of Botany, Jamal Mohamed College, Tiruchirappalli, Tamilnadu, India.
authors.forename: V
authors.initials: V
authors.lastname: Malayaman
authors.affiliation: Nanotechnology Research Lab, Department of Physics, Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India.
authors.forename: B
authors.initials: B
authors.lastname: Chandarshekar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002563:Cerium / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D002563:Cerium; C030583:ceric oxide; D048271:Chitosan
keywords: Cerium oxide nanoparticles; Chitosan; Sida acuta