title: Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals.
abstract: To examine how serum lipids relates to specific cognitive ability domains between the men and women in Chinese middle to older age individuals. A complete lipid panel was obtained from 1444 individuals, ages 50-65, who also underwent a selection of cognitive tests. Participants were 584 men and 860 women from Linyi city, Shandong province. Multiple linear regression analyses examined serum lipids level as quadratic predictors of sex-specific measure of performance in different cognitive domains, which were adjusted for sociodemographic and lifestyle characteristics. In men, a significant quadratic effect of total cholesterol (TC) was identified for Digit Symbol (B = -0.081, P = 0.044) and also quadratic effect of low density lipoprotein-cholesterol (LDL-C) was identified for Trail Making Test B (B = -0.082, P = 0.045). Differently in women, there were significant quadratic associations between high density lipoprotein-cholesterol (HDL-C) and multiple neuropsychological tests. The nonlinear lipid-cognition associations differed between men and women and were specific to certain cognitive domains and might be of potential relevance for prevention and therapy of cognitive decline.
authors.affiliation: School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.|Linyi Mental Health Center, Linyi, Shandong, China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Lu
authors.affiliation: School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: An
authors.affiliation: School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
authors.forename: Huanling
authors.initials: H
authors.lastname: Yu
authors.affiliation: Linyi People's Hospital, Linyi, Shandong, China.
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Che
authors.affiliation: School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
authors.forename: Hongguo
authors.initials: H
authors.lastname: Rong
authors.affiliation: School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
authors.forename: Yuandi
authors.initials: Y
authors.lastname: Xi
authors.affiliation: School of Public Health, Capital Medical University, No.10 Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China. xiaor22@ccmu.edu.cn.
authors.forename: Rong
authors.initials: R
authors.lastname: Xiao
mesh_terms: D000368:Aged; D002784:Cholesterol / Q000097:blood*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D002784:Cholesterol
keywords: Cholesterol; Cognitive performance; Different domains; Nonlinear associations; Serum lipids; Sex