title: Plasma Vitamin D Deficiency Is Associated With Poor Sleep Quality and Night-Time Eating at Mid-Pregnancy in Singapore.
abstract: Plasma 25-hydroxyvitamin D (25OHD) deficiency, poor sleep quality, and night-time eating, have been independently associated with adverse pregnancy outcomes, but their inter-relationships are yet to be evaluated. We aimed to investigate the associations between maternal plasma 25OHD status and sleep quality and circadian eating patterns during pregnancy. Data on pregnant women (n= 890) from a prospective cohort (Growing Up in Singapore Towards healthy Outcomes) were analyzed. Plasma 25OHD concentration was measured, while the Pittsburgh sleep quality index (PSQI) and 24-h dietary recall were administered to women at 26-28 weeks' gestation. Plasma 25OHD status was defined as sufficient (>75 nmol/L), insufficient (50-75 nmol/L), or deficient (<50 nmol/L). Poor sleep quality was defined by a total global PSQI score >5. Predominantly day-time (pDT) and predominantly night-time (pNT) were defined according to consumption of greater proportion of calories (i.e., >50%) from 07:00-18:59 and from 19:00-06:59, respectively. After adjustment for confounders, women with plasma 25OHD deficiency had higher odds of poor sleep quality (odds ratio (OR) 3.49; 95% confidence interval (CI) 1.84-6.63) and pNT eating (OR: 1.85; 95% CI 1.00-3.41) than those who were 25OHD sufficient. Our findings show the association of maternal plasma 25OHD deficiency with poor sleep quality and pNT eating at mid-pregnancy.
authors.affiliation: Department of Paediatrics, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore. tscheng1988@gmail.com.|School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong, China. tscheng1988@gmail.com.
authors.forename: Tuck Seng
authors.initials: TS
authors.lastname: Cheng
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore. loy.see.ling@kkh.com.sg.|Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. loy.see.ling@kkh.com.sg.
authors.forename: See Ling
authors.initials: SL
authors.lastname: Loy
authors.affiliation: Center for Quantitative Medicine, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. yinbun.cheung@duke-nus.edu.sg.|Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Kalevantie 4, Tampere 33100, Finland. yinbun.cheung@duke-nus.edu.sg.
authors.forename: Yin Bun
authors.initials: YB
authors.lastname: Cheung
authors.affiliation: Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore. obgcais@nus.edu.sg.
authors.forename: Shirong
authors.initials: S
authors.lastname: Cai
authors.affiliation: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, (A*STAR), 30 Medical Drive, Singapore 117609, Singapore. marjorelee_colega@sics.a-star.edu.sg.
authors.forename: Marjorelee T
authors.initials: MT
authors.lastname: Colega
authors.affiliation: MRC Lifecourse Epidemiology Unit, University of Southampton, University Road, Southampton SO17 1BJ, UK. kmg@mrc.soton.ac.uk.|NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, University Road, Southampton SO17 1BJ, UK. kmg@mrc.soton.ac.uk.
authors.forename: Keith M
authors.initials: KM
authors.lastname: Godfrey
authors.affiliation: Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore. obgcys@nus.edu.sg.|Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, (A*STAR), 30 Medical Drive, Singapore 117609, Singapore. obgcys@nus.edu.sg.
authors.forename: Yap-Seng
authors.initials: YS
authors.lastname: Chong
authors.affiliation: Maternal Fetal Medicine, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore. tan.kok.hian@kkh.com.sg.
authors.forename: Kok Hian
authors.initials: KH
authors.lastname: Tan
authors.affiliation: Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore. lynette_shek@nuhs.edu.sg.|Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. lynette_shek@nuhs.edu.sg.
authors.forename: Lynette Pei-Chi
authors.initials: LP
authors.lastname: Shek
authors.affiliation: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, (A*STAR), 30 Medical Drive, Singapore 117609, Singapore. yung_seng_lee@nuhs.edu.sg.|Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore. yung_seng_lee@nuhs.edu.sg.|Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore. yung_seng_lee@nuhs.edu.sg.
authors.forename: Yung Seng
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Department of Paediatrics, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore. lek.ngee@singhealth.com.sg.|Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. lek.ngee@singhealth.com.sg.
authors.forename: Ngee
authors.initials: N
authors.lastname: Lek
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore. jerrychan@duke-nus.edu.sg.|Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. jerrychan@duke-nus.edu.sg.
authors.forename: Jerry Kok Yen
authors.initials: JK
authors.lastname: Chan
authors.affiliation: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, (A*STAR), 30 Medical Drive, Singapore 117609, Singapore. mary_chong@sics.a-star.edu.sg.|Saw Swee Hock School of Public Health, National University of Singapore, 1E Kent Ridge Rd 119228, NUHS Tower Block, Level 11, Singapore 117597, Singapore. mary_chong@sics.a-star.edu.sg.|Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 14 Medical Drive #07-02, MD 6 Building, Singapore 117599, Singapore. mary_chong@sics.a-star.edu.sg.
authors.forename: Mary Foong-Fong
authors.initials: MF
authors.lastname: Chong
authors.affiliation: Department of Paediatrics, KK Women's and Children's Hospital, 100, Bukit Timah Road, Singapore 229899, Singapore. fabian.yap.k.p@singhealth.com.sg.|Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore. fabian.yap.k.p@singhealth.com.sg.|Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Ave, Singapore 639798, Singapore. fabian.yap.k.p@singhealth.com.sg.
authors.forename: Fabian
authors.initials: F
authors.lastname: Yap
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D016017:Odds Ratio; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012846:Singapore; D012893:Sleep Wake Disorders / Q000097:blood / Q000209:etiology*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: behavioral circadian rhythms; predominantly night-time eating; sleep quality; vitamin D