title: Bioimpedancemetry for the assessment of periodontal tissue inflammation: a numerical feasibility study.
abstract: In dentistry possible inflammatory episodes of oral cavity can be very frequent (periodontitis, mucositis, peri-implantitis) and they can have serious consequences. Indeed, peri-implantitis is still the principal cause of implant failure. Impedance values of biological tissues are related to the physiological/pathological state of the tissue itself. In fact, an inflamed site exhibits an impedance value lower than that of the corresponding healthy tissue. Based on these observations, the aim of this work is to determine if impedancemetric measurements are able to provide information about the inflammatory state of tissues. A numerical 3D model has been realized to simulate the measurement conditions present in the event of inflammation around a dental implant. The aim is to understand if it is possible to determine the presence of an inflamed tissue and to locate its site, so that the treatment could be specifically focused in that specific area. A simplified geometry reproducing the implant has been realized in order to validate the numerical model by means of experimental measurements. The obtained results are satisfactorily accurate, so the model can be considered reliable. Therefore, multiple simulations have been run on the original model to carry out a parametric study in terms of different conductivity values, different volumes of inflamed tissues and different measurement frequencies. The advantages and limits of such a method have been shown to properly define the main constraints for the system design.
authors.affiliation: a Dipartimento di Ingegneria Industriale e Scienze Matematiche , Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Gloria
authors.initials: G
authors.lastname: Cosoli
authors.affiliation: a Dipartimento di Ingegneria Industriale e Scienze Matematiche , Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Scalise
authors.affiliation: b Dipartimento di Ingegneria dell'Informazione , Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Graziano
authors.initials: G
authors.lastname: Cerri
authors.affiliation: b Dipartimento di Ingegneria dell'Informazione , Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Russo
authors.affiliation: c Studio Medico Tricarico s.r.l. , Chiaravalle , Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Tricarico
authors.affiliation: a Dipartimento di Ingegneria Industriale e Scienze Matematiche , Università Politecnica delle Marche , Ancona , Italy.
authors.forename: Enrico Primo
authors.initials: EP
authors.lastname: Tomasini
mesh_terms: D003198:Computer Simulation; D017097:Electric Impedance; D004560:Electricity; D004566:Electrodes; D005240:Feasibility Studies; D005881:Gingiva / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008962:Models, Theoretical; D009716:Numerical Analysis, Computer-Assisted; D010518:Periodontitis / Q000473:pathology*; D015203:Reproducibility of Results
keywords: Inflammation; alternating current (AC); dentistry; human tooth; impedance; numerical simulation