title: Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour.
abstract: To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs were approximately spherical shape with good stability. IVM was encapsulated in amorphous form within SLNs and displayed prolonged release from SLNs without burst release due to high encapsulation efficiency (EE). The cumulative permeation of IVM across excised rat skin from SLNs was significantly increased compared to the ivermection suspension. These results indicated that the proposed SLNs can be considered as an efficient carrier for dermal delivery of IVM to effectively treat scabies.
authors.affiliation: a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Guo
authors.affiliation: a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Dou
authors.affiliation: a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Li
authors.affiliation: a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.
authors.forename: Zohaib Ahmed
authors.initials: ZA
authors.lastname: Bhutto
authors.affiliation: a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004355:Drug Stability; D007559:Ivermectin / Q000737:chemistry* / Q000378:metabolism*; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010539:Permeability; D051381:Rats; D012867:Skin / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D008055:Lipids; D007559:Ivermectin
keywords: Solid lipid nanoparticles; ivermectin; transdermal drug delivery; ultrasonic technique