title: [Autophagy, fitness and longevity].
abstract: Autophagy is a key mechanism for the maintenance of intracellular and organismal homeostasis. Accordingly, defects in core components of the autophagic machinery are etiologically associated with a variety of human pathologies, including infectious disorders, cardiovascular diseases, neurodegenerative conditions, and cancer. Intriguingly, several maneuvers that increase the lifespan of model organisms in the laboratory, like caloric restriction, do so in an autophagy-dependent manner. Here, we briefly discuss the intimate relationship between the autophagic preservation of intracellular and organismal fitness and healthy aging.
authors.affiliation: Department of radiation oncology, Weill Cornell Medical College, New York, NY, États-Unis - Inserm UMRS 1138, Paris, France - Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie/Paris VI, Paris, France - Équipe 11 labellisée par la Ligue nationale contre le cancer, Centre de recherche des Cordeliers, Paris, France - Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.affiliation: Inserm UMRS 1138, Paris, France - Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie/Paris VI, Paris, France - Équipe 11 labellisée par la Ligue nationale contre le cancer, Centre de recherche des Cordeliers, Paris, France - Gustave Roussy Cancer Campus, Villejuif, France.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Bravo-San Pedro
authors.affiliation: Inserm UMRS 1138, Paris, France - Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France - Université Pierre et Marie Curie/Paris VI, Paris, France - Équipe 11 labellisée par la Ligue nationale contre le cancer, Centre de recherche des Cordeliers, Paris, France - Pôle de biologie, hôpital européen Georges Pompidou, AP-HP, Paris, France - Metabolomics and cell biology platforms, Gustave Roussy Cancer Campus, Villejuif, France - Department of Women's and Children's Health, Karolinska university hospital, Stockholm, Suède.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006262:Health; D006801:Humans; D008136:Longevity / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology; D015398:Signal Transduction