title: Role of Physicochemical Properties in Nanoparticle Toxicity.
abstract: With the recent rapid growth of technological comprehension in nanoscience, researchers have aimed to adapt this knowledge to various research fields within engineering and applied science. Dramatic advances in nanomaterials marked a new epoch in biomedical engineering with the expectation that they would have huge contributions to healthcare. However, several questions regarding their safety and toxicity have arisen due to numerous novel properties. Here, recent studies of nanomaterial toxicology will be reviewed from several physiochemical perspectives. A variety of physiochemical properties such as size distribution, electrostatics, surface area, general morphology and aggregation may significantly affect physiological interactions between nanomaterials and target biological areas. Accordingly, it is very important to finely tune these properties in order to safely fulfill a bio-user's purpose.
authors.affiliation: School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Korea. seung3885@skku.edu.
authors.forename: Seung Won
authors.initials: SW
authors.lastname: Shin
authors.affiliation: School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Korea. songinhyun@skku.edu.
authors.forename: In Hyun
authors.initials: IH
authors.lastname: Song
authors.affiliation: School of Chemical Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Korea. sh.um@skku.edu.|SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Korea. sh.um@skku.edu.
authors.forename: Soong Ho
authors.initials: SH
authors.lastname: Um
keywords: nanomaterials; nanotoxicology; physiological properties