title: Myositis non-inflammatory mechanisms: An up-dated review.
abstract: Idiopathic inflammatory myopathies (IIM) represent a heterogeneous group of rare muscular diseases, with no clearly known causes. IIM frequently have an incomplete response to treatment due to the difficulty in distinguishing between IIM forms, and due to neglect their non-inflammatory causes. Important data concerning non-immune mechanisms in IIM pathology have been recently accumulated. There is a correlation between inflammatory and non-inflammatory mechanisms, but their involvement in IIM pathogenesis is still unknown. Here we review some of the most important data regarding the non-immune IIM pathology, highlighting possible future therapeutic targets: endoplasmic reticulum stress, ATP metabolism, ROS generation, autophagy, and microRNAs disturbances.
authors.affiliation: a "Victor Babes" National Institute of Pathology , Bucharest , Romania.|b Research Center , Colentina Clinical Hospital , Bucharest , Romania.
authors.forename: Emilia
authors.initials: E
authors.lastname: Manole
authors.affiliation: c Pathology Department , Colentina Clinical Hospital , Bucharest , Romania.|d "Carol Davila" University of Medicine and Pharmacy , Bucharest , Romania.
authors.forename: Alexandra E
authors.initials: AE
authors.lastname: Bastian
authors.affiliation: e Pediatric Neurology Department , Clinical Hospital "Prof. Dr. Al. Obregia" , Bucharest , Romania.
authors.forename: Niculina
authors.initials: N
authors.lastname: Butoianu
authors.affiliation: f Department of Neuropathology , Charité - Universitätsmedizin Berlin , Berlin , Germany.
authors.forename: Hans H
authors.initials: HH
authors.lastname: Goebel
mesh_terms: D001343:Autophagy; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D009220:Myositis / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D017382:Reactive Oxygen Species
keywords: ER stress; ROS; autophagy; idiopathic inflammatory myopathies; muscular microRNAs; myositis