title: Regulation of mRNA stability by CCCH-type zinc-finger proteins in immune cells.
abstract: Current studies using knockout mice have revealed that some Cys-Cys-Cys-His (CCCH)-type zinc-finger proteins, namely tristetraprolin (TTP), Roquin and Regnase-1, play important roles in the immune system. These proteins are closely associated with the fate of their target RNAs in normal immune responses. However, the functions of many RNA-binding proteins have not been characterized precisely. To understand the molecular mechanisms of RNA metabolism in the immune system, investigation of TTP/Roquin/Regnase-1 might provide new knowledge. In this review, we will discuss the current understanding of these proteins in immune regulation and homeostasis and discuss RNA metabolism in the immune system.
authors.affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC).|Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Laboratory of Host Defense, WPI Immunology Frontier Research Center (IFReC).|Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
authors.forename: Shizuo
authors.initials: S
authors.lastname: Akira
mesh_terms: D000818:Animals; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007109:Immunity; D056747:Immunomodulation; D020871:RNA Stability; D012333:RNA, Messenger / Q000276:immunology / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012260:Ribonucleases / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D051816:Tristetraprolin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: C000592051:RC3H1 protein, human; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D051816:Tristetraprolin; D044767:Ubiquitin-Protein Ligases; D012260:Ribonucleases; C510646:ZC3H12A protein, human
keywords: RNA-binding protein; inflammatory cytokine; mRNA stability; zinc-finger protein