title: The tug-of-war over MTOR inLegionellainfections.
abstract: A ruptured bacteria-containing organelle within the cytosol of an infected eukaryotic cell frequently initiates host defense responses that restrict pathogen replication. Therefore, source for lipids must be found to accommodate the organelle membrane expansion required to support bacterial replication. How host cells are manipulated to provide lipids for the expansion of pathogen-occupied organelles is not well understood. By investigating the interaction between macrophages and the human pulmonary pathogenLegionella pneumophilawe uncovered that the host metabolic checkpoint kinase Mechanistic target of rapamycin (MTOR) is a central regulator of the pathogen niche expansion program.
authors.affiliation: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center - Shreveport, Shreveport, LA 71130.
authors.forename: Stanimir S
authors.initials: SS
authors.lastname: Ivanov
keywords: Legionella; MTOR; PI3K; SREBP; intracellular pathogens; lipids; lipogenesis; macrophage