title: Video-assisted thoracoscopy in the management of intrapleural extravasation of cytotoxic chemotherapy.
abstract: The extravasation of cytotoxic agents into subcutaneous tissue is a serious complication of chemotherapy. Unfortunately, if such extravasation occurs into the pleural space, limited data is available to guide appropriate management. We present the first report in the literature of video-assisted thoracoscopy combined with a topoisomerase II inhibitor and iron chelator, dexrazoxane, in the successful management of this complication.
authors.affiliation: Cardiothoracic Surgical Unit, Department of Cardiothoracic Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Aguirre
authors.affiliation: Cardiothoracic Surgical Unit, Department of Cardiothoracic Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Dylan
authors.initials: D
authors.lastname: Barnett
authors.affiliation: Cardiothoracic Surgical Unit, Department of Cardiothoracic Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Nikki
authors.initials: N
authors.lastname: Burdett
authors.affiliation: Cardiothoracic Surgical Unit, Department of Cardiothoracic Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Rohit
authors.initials: R
authors.lastname: Joshi
authors.affiliation: Cardiothoracic Surgical Unit, Department of Cardiothoracic Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Fabiano F
authors.initials: FF
authors.lastname: Viana
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy; D003131:Combined Modality Therapy; D064730:Dexrazoxane / Q000008:administration & dosage* / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D008875:Middle Aged; D020775:Thoracic Surgery, Video-Assisted; D013906:Thoracoscopy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D064730:Dexrazoxane; D004317:Doxorubicin
keywords: 
  Anthracycline toxicity; chemotherapy complication; dexrazoxane; mal-positioned central line; video-assisted thoracoscopy