title: Association analyses identify two susceptibility loci 5q31 and 5q22.1 for atopic dermatitis in Chinese Han population.
abstract: BACKGROUND
  Atopic dermatitis (AD) and other atopic diseases often share some common genetic and pathogenic bases. Recent genome-wide association studies (GWAS) have identified several loci associated with atopic diseases, allergic sensitization and asthma in different populations. The aim of this study was to investigate whether these susceptibility loci were related to AD in Chinese Han population.
  
  
  METHODS
  Eight single nucleotide polymorphisms (SNPs) from recent atopic diseases and allergic sensitization GWAS were genotyped in 3,013 AD patients and 5,483 healthy controls in Chinese Han population using Sequenom MassArray system. Data was analyzed with PLINK 1.07 software.
  
  
  RESULTS
  We identified that the susceptibility loci at 5q31 (RAD50/IL13, rs2158177, P = 1.08×10-3, OR = 1.15) and 5q22.1 (TSLP, rs1837253, P = 2.66×10-3, OR = 0.91) were significantly associated with AD. Genotype-based association testing revealed that the dominant model provided the best fit for both rs2158177 (P = 3.75×10-3) and rs1837253 (P = 5.30×10-3). Pathway analysis conformed that both loci were associated with the JAK-STAT signaling pathway.
  
  
  CONCLUSIONS
  We identified two susceptibility loci 5q31 and 5q22.1 for AD that might bear candidate genes conferring susceptibility to AD.
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Jiang
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Zhao
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Chong-Xian
authors.initials: CX
authors.lastname: Yu
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Fang
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zheng
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xian-Yong
authors.initials: XY
authors.lastname: Yin
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Wu
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xian-Fa
authors.initials: XF
authors.lastname: Tang
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Fu-Sheng
authors.initials: FS
authors.lastname: Zhou
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, China.|State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, China.
authors.forename: Feng-Li
authors.initials: FL
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002681:China; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D019295:Computational Biology; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult