title: Broadly Neutralizing Antibodies as Treatment: Effects on Virus and Immune System.
abstract: The purpose of this study is to summarize recent advances in the use of broadly neutralizing antibodies (bNAbs) as therapeutics in human clinical trials and in non-human primate (NHP) models. We seek to highlight lessons from these studies with an emphasis on consequences to the virus and immune system.
  
  
  
  In the past 10 years, advances in HIV-1 trimer structure and B cell isolation methods have precipitated the identification of "new-generation" anti-HIV antibodies with broad and potent neutralization. In the past 2 years, the concept of using these bNAbs as therapeutic tools has moved from NHP models into human clinical trials. These trials have investigated the effects of bNAb infusions into patients chronically infected with HIV-1, while the NHP model has investigated treatment during acute infection. Through this work, the relationship between in vitro breadth and potency and in vivo clinical effect, although unresolved, is gradually being elucidated. These results emphasize the need for combination antibody therapy.
authors.affiliation: Centre for HIV and STIs, National Institute for Communicable Diseases (NICD), National Health Laboratory Service (NHLS), 1 Modderfontein Road, Sandringham, Johannesburg, Gauteng, 2131, South Africa.|Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: Jinal N
authors.initials: JN
authors.lastname: Bhiman
authors.affiliation: Department of Microbiology, Immunology and Tropical Medicine, George Washington University, 2300 Eye St. NW, Washington, DC, 20001, USA. rmlynch@gwu.edu.
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Lynch
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D001402:B-Lymphocytes; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies
keywords: Broadly neutralizing antibodies; HIV-1, monoclonal antibodies; Passive therapy; Virus escape