title: Low Variability and Stable Frequency of Common Haplotypes of theTP53Gene Region in Colorectal Cancer Patients in a Slovak Population.
abstract: To test the association between common TP53 haplotypes and colorectal cancer (CRC) development.
  
  
  
  A total of 277 CRC patients and 167 healthy volunteers were included in the study. Common TP53 haplotypes were estimated from eight single-nucleotide polymorphisms (SNPs) (rs1614984, rs77697176, rs12947788, rs1800372, rs2909430, rs1042522, rs17878362 and rs11652704). Stepwise haplotype trend regression showed the haplotype-regressor cccgaRDa as a possible predictive marker.
  
  
  
  The rare haplotype cccgaRDa was identified in 10 CRC cases and 3 controls. Although it is approximately twice as common in CRC (odds ratio (OR)=2.068; 95% confidence interval (CI)=0.471-9.069), the cccgaRDa haplotype frequency is low in the studied groups. Results of our study suggest that the common TP53 variability is relatively low (only 3 haplotypes occurred above 10%).
  
  
  
  The haplotype background of TP53 gene is relative stable and despite low haplotype-regressor cccgaRDa frequency it shows to be a possible predictive parameter for CRC development.
authors.affiliation: Department of Clinical Biochemistry, University Hospital, Martin, Slovak Republic.
authors.forename: Mária
authors.initials: M
authors.lastname: Škereňová
authors.affiliation: Department of Molecular Medicine, Martin Biomedical Centre, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic.|Department of Medical Biology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic.
authors.forename: Erika
authors.initials: E
authors.lastname: Halašová
authors.affiliation: Department of Molecular Medicine, Martin Biomedical Centre, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic matakova@jfmed.uniba.sk.|Department of Medical Biochemistry, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Matáková
authors.affiliation: Department of Clinical Biochemistry, University Hospital, Martin, Slovak Republic.
authors.forename: Ľubica
authors.initials: Ľ
authors.lastname: Jesenská
authors.affiliation: Department of Molecular Medicine, Martin Biomedical Centre, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Jurečeková
authors.affiliation: Department of Molecular Medicine, Martin Biomedical Centre, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Šarlinová
authors.affiliation: Department of Clinical Biochemistry, University Hospital, Martin, Slovak Republic.
authors.forename: Daniel
authors.initials: D
authors.lastname: Čierny
authors.affiliation: Department of Clinical Biochemistry, University Hospital, Martin, Slovak Republic.|Department of Medical Biochemistry, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovak Republic.
authors.forename: Dušan
authors.initials: D
authors.lastname: Dobrota
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D016158:Genes, p53 / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D018154:Slovakia / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor
keywords: CRC; TP53 gene; association; haplotype; tagSNP