title: Forecastable and Guidable Bubble-Propelled Microplate Motors for Cell Transport.
abstract: Cell transport is important to renew body functions and organs with stem cells, or to attack cancer cells with immune cells. The main hindrances of this method are the lack of understanding of cell motion as well as proper transport systems. In this publication, bubble-propelled polyelectrolyte microplates are used for controlled transport and guidance of HeLa cells. Cells survive attachment on the microplates and up to 22 min in 5% hydrogen peroxide solution. They can be guided by a magnetic field whereby increased friction of cells attached to microplates decreases the speed by 90% compared to pristine microplates. The motion direction of the cell-motor system is easier to predict due to the cell being opposite to the bubbles.
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nano Technology Research Centre, Harbin Institute of Technology, Yikuang Street 2, Harbin, 150080, China.|Oral Implant Center, Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
authors.forename: Narisu
authors.initials: N
authors.lastname: Hu
authors.affiliation: Oral Implant Center, Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: School of Materials Engineering, Queen Mary University of London, Mile End Road 215, E1 4NS, London, UK.
authors.forename: Meiyu
authors.initials: M
authors.lastname: Gai
authors.affiliation: Medical Affairs Department, Harbin Medical University, Harbin, 150001, China.
authors.forename: Ce
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nano Technology Research Centre, Harbin Institute of Technology, Yikuang Street 2, Harbin, 150080, China.
authors.forename: Johannes
authors.initials: J
authors.lastname: Frueh
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nano Technology Research Centre, Harbin Institute of Technology, Yikuang Street 2, Harbin, 150080, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
mesh_terms: D002384:Catalysis; D002465:Cell Movement; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide; D060526:Magnetic Fields; D009038:Motion
chemical_list: D006861:Hydrogen Peroxide
keywords: bubble propulsion; cell transport; motion analysis; motion control; plate micromotor