title: Satisfaction, quality of life and perception of patients regarding burdens and benefits of vitamin K antagonists compared with direct oral anticoagulants in patients with nonvalvular atrial fibrillation.
abstract: OBJECTIVE
  To compare the satisfaction of patients treated with vitamin K antagonists (VKA) with that of patients treated with direct oral anticoagulants (DOACs) and to determine the impact on quality of life of both treatments in patients with nonvalvular atrial fibrillation (NVAF).
  
  
  METHODS
  Cross-sectional multicenter study in which outpatients with NVAF completed the ACTS (Anti-Clot Treatment Scale), SAT-Q (Satisfaction Questionnaire) and EQ-5D-3L (EuroQol 5 dimensions questionnaire, 3 level version) questionnaires.
  
  
  RESULTS
  The study population comprised 1337 patients, of whom 587 were taking DOACs and 750 VKAs. Compared with VKAs, DOACs were more commonly prescribed in patients with a history of stroke and in patients with a higher thromboembolic risk. The study scores were as follows: SAT-Q: 63.8 ± 17.8; EQ-5D-3L total score: 75.6 ± 20.9; visual analog scale: 63.1 ± 20.6; ACTS Burdens: 51.8 ± 8.4 and ACTS Benefits: 11.9 ± 2.4. The ACTS Burdens score and ACTS Benefits score were higher with DOACs than with VKAs (54.83 ± 6.11 vs 49.50 ± 9.15; p < 0.001 and 12.36 ± 2.34 vs 11.48 ± 2.46; p < 0.001 respectively).
  
  
  CONCLUSIONS
  NVAF patients treated with oral anticoagulants had many comorbidities and a high thromboembolic risk. Satisfaction and quality of life with oral anticoagulants were high, although they were both better with DOACs than with VKAs.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Ma Del Mar
authors.initials: MDM
authors.lastname: Contreras Muruaga
authors.affiliation: Servicio de Neurología, Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Vivancos
authors.affiliation: Servicio de Neurología, Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Reig
authors.affiliation: Servicio de Neurología y Neurofisiología Clínica, Hospital San Roque Las Palmas, Las Palmas, Spain.
authors.forename: Ayoze
authors.initials: A
authors.lastname: González
authors.affiliation: Servicio de Neurología, Hospital Universitario de Bellvitge (HUB), Barcelona, Spain.
authors.forename: Pere
authors.initials: P
authors.lastname: Cardona
authors.affiliation: Unidad de Ictus. Servicio de Neurología. Departamento de Ciencias Biomédicas. Hospital Universitario Infanta Cristina, Madrid, Spain.
authors.forename: José Mª
authors.initials: JM
authors.lastname: Ramírez-Moreno
authors.affiliation: Servicio de Neurología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: Joan
authors.initials: J
authors.lastname: Martí
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario de La Princesa, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Suárez Fernández
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications* / Q000523:psychology; D057186:Comparative Effectiveness Research; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D006801:Humans; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*; D012306:Risk; D020521:Stroke / Q000517:prevention & control*; D011795:Surveys and Questionnaires; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D014812:Vitamin K
keywords: ACTS; EQ-5D-3L; SAT-Q; atrial fibrillation; benefit; burdens; oral anticoagulation; quality of life; satisfaction