title: Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice.
abstract: Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters. Adiponectin expression was increased in the visceral adipose tissue, and the subcutaneous and visceral adipose tissues were more insulin sensitive and less inflamed in F. prausnitzii-treated mice. Further, F. prausnitzii treatment increased muscle mass that may be linked to enhanced mitochondrial respiration, modified gut microbiota composition and improved intestinal integrity. Our findings show that F. prausnitzii treatment improves hepatic health, and decreases adipose tissue inflammation in mice and warrant the need for further studies to discover its therapeutic potential.
authors.affiliation: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.|Department of Medical Microbiology and Immunology, Diagnostic and Related Services of Turku University Hospital, Turku, Finland.
authors.forename: Eveliina
authors.initials: E
authors.lastname: Munukka
authors.affiliation: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.|Department of Medical Microbiology and Immunology, Diagnostic and Related Services of Turku University Hospital, Turku, Finland.
authors.forename: Anniina
authors.initials: A
authors.lastname: Rintala
authors.affiliation: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
authors.forename: Raine
authors.initials: R
authors.lastname: Toivonen
authors.affiliation: Department of Biochemistry, Food Chemistry and Food Development, University of Turku, Turku, Finland.
authors.forename: Matts
authors.initials: M
authors.lastname: Nylund
authors.affiliation: Department of Biochemistry, Food Chemistry and Food Development, University of Turku, Turku, Finland.
authors.forename: Baoru
authors.initials: B
authors.lastname: Yang
authors.affiliation: Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
authors.forename: Anna
authors.initials: A
authors.lastname: Takanen
authors.affiliation: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.|Department of Medical Microbiology and Immunology, Diagnostic and Related Services of Turku University Hospital, Turku, Finland.
authors.forename: Arno
authors.initials: A
authors.lastname: Hänninen
authors.affiliation: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Vuopio
authors.affiliation: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
authors.forename: Pentti
authors.initials: P
authors.lastname: Huovinen
authors.affiliation: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.|Medicity Research Laboratory, University of Turku, Turku, Finland.
authors.forename: Sirpa
authors.initials: S
authors.lastname: Jalkanen
authors.affiliation: Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.|Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
authors.forename: Satu
authors.initials: S
authors.lastname: Pekkala
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D000070037:Faecalibacterium prausnitzii / Q000502:physiology*; D007249:Inflammation / Q000139:chemically induced* / Q000628:therapy*; D007333:Insulin Resistance; D007413:Intestinal Mucosa / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000145:classification; D008099:Liver / Q000378:metabolism*; D051379:Mice
chemical_list: D004041:Dietary Fats; D008055:Lipids