title: THE MANAGEMENT OF AN ORAL ANAPLASTIC SARCOMA IN A PYGMY HIPPOPOTAMUS (CHOEROPSIS LIBERIENSIS) USING INTRALESIONAL CHEMOTHERAPY.
abstract: An adult female captive pygmy hippopotamus (Choeropsis liberiensis) was diagnosed with an oral anaplastic sarcoma. The tumor was surgically debulked and intralesional chemotherapy with mitomycin C (0.4 mg/cm3of tumor) and cisplatin (1 mg/cm3of tumor) was administered. Chemotherapeutic treatment proved difficult due to the risks of repeated anesthetics and unknown drug efficacies. Marked proliferation of the mass was observed during estrus, and chemotherapy was repeated as an experimental treatment to slow tumor progression in order for the animal to remain in the species breeding program. Tumor proliferation was detected during the first trimester of pregnancy; however, in the lactation period, the mass became quiescent. No adverse reactions to chemotherapeutic drugs were observed and the animal continues to be monitored for tumor progression. This is the first report of an anaplastic sarcoma and of chemotherapy use in a pygmy hippopotamus and it highlights logistical considerations for treating neoplasia in this species.
authors.forename: Lydia H V
authors.initials: LH
authors.lastname: Franklinos
authors.forename: Nicholas
authors.initials: N
authors.lastname: Masters
authors.forename: Yedra
authors.initials: Y
authors.lastname: Feltrer
authors.forename: Ann
authors.initials: A
authors.lastname: Pocknell
authors.forename: David M
authors.initials: DM
authors.lastname: Bolt
authors.forename: Stephanie
authors.initials: S
authors.lastname: Dakin
authors.forename: Karla
authors.initials: K
authors.lastname: Berry
authors.forename: Fieke M
authors.initials: FM
authors.lastname: Molenaar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001188:Artiodactyla; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D030762:Estrous Cycle; D005260:Female; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D011247:Pregnancy; D012509:Sarcoma / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D016685:Mitomycin; D002945:Cisplatin
keywords: Anaplastic sarcoma; Choeropsis liberiensis; intralesional chemotherapy; mitomycin C; oral tumor; pygmy hippopotamus