title: Cytophysiological Changes in the Follicular Epithelium of the Thyroid Gland after Long-Term Exposure to Low Doses of Dichlorodiphenyltrichloroethane (DDT).
abstract: Exposure to endocrine disruptors is considered as a risk factor thyroid gland diseases. We analyzed cytophysiological changes in rat thyroid follicular epithelium after long-term exposure to low doses of the most widespread disruptor DDT. Analysis of thyroid hormone production and light and electron microscopy of thyroid gland samples revealed cytophysiological changes in thyroid epithelium related to impaired transport through the apical membrane, suppressed Golgi complex activity, and impaired thyrotrophic hormone regulation of the secretory functions of thyroid cells, which led to compensatory transition from merocrine to microapocrine secret release.
authors.affiliation: Research Institute of Human Morphology, Moscow, Russia. yaglova@mail.ru.
authors.forename: N V
authors.initials: NV
authors.lastname: Yaglova
authors.affiliation: Research Institute of Human Morphology, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Yaglov
mesh_terms: D000818:Animals; D003634:DDT / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D008297:Male; D010575:Pesticides / Q000633:toxicity*; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology
chemical_list: D010575:Pesticides; D003634:DDT
keywords: cytophysiology; dichlorodiphenyltrichloroethane; follicular epithelium; secretion; thyroid gland