title: Determination of fluvoxamine maleate in human urine and human serum using alkaline KMnO4-rhodamine B chemiluminescence.
abstract: The flow-injection chemiluminescence (FI-CL) behavior of a gold nanocluster (Au NC)-enhanced rhodamine B-KMnO4system was studied under alkaline conditions for the first time. In the present study, the as-prepared bovine serum albumin-stabilized Au NCs showed excellent stability and reproducibility. The addition of trace levels of fluvoxamine maleate (Flu) led to an obvious decline in CL intensity in the rhodamine B-KMnO4-Au NCs system, which could be used for quantitative detection of Flu. Under optimized conditions, the proposed CL system exhibited a favorable analytical performance for Flu determination in the range 2 to 100 μg ml-1. The detection limit for Flu measurement was 0.021 μg ml-1. Moreover, this newly developed system revealed outstanding selectivity for Flu detection when compared with a multitude of other species, such as the usual ions, uric acid and a section of hydroxy compounds. Additionally, CL spectra, UV-visible spectroscopes and fluorescence spectra were measured in order to determine the possible reaction mechanism. This approach could be used to detect Flu in human urine and human serum samples with the desired recoveries and could have promising application under physiological conditions.
authors.affiliation: The Key Laboratory of Luminescence and Real-time Analytical Chemistry, Ministry of Education; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, People's Republic of China.
authors.forename: Dongqin
authors.identifier: http://orcid.org/0000-0002-9264-3745
authors.initials: D
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Luminescence and Real-time Analytical Chemistry, Ministry of Education; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, People's Republic of China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: He
authors.affiliation: The Key Laboratory of Luminescence and Real-time Analytical Chemistry, Ministry of Education; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, People's Republic of China.
authors.forename: Funan
authors.initials: F
authors.lastname: Chen
mesh_terms: D014151:Anti-Anxiety Agents / Q000097:blood* / Q000652:urine*; D016666:Fluvoxamine / Q000097:blood* / Q000652:urine*; D006046:Gold / Q000737:chemistry; D006801:Humans; D057230:Limit of Detection; D049449:Luminescence; D008163:Luminescent Measurements / Q000379:methods*; D011196:Potassium Permanganate / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D014151:Anti-Anxiety Agents; D012235:Rhodamines; D011196:Potassium Permanganate; D012710:Serum Albumin, Bovine; D006046:Gold; C029773:rhodamine B; D016666:Fluvoxamine
keywords: Chemiluminescence; fluvoxamine maleate; gold nanoclusters; rhodamine B