title: In Vitro Incorporation of Radioiodinated Eugenol on Adenocarcinoma Cell Lines (Caco2, MCF7, and PC3).
abstract: Recently, the synthesis of radiolabeled plant origin compounds has been increased due to their high uptake on some cancer cell lines. Eugenol (EUG), a phenolic natural compound in the essential oils of different spices such as Syzygium aromaticum (clove), Pimenta racemosa (bay leaves), and Cinnamomum verum (cinnamon leaf), has been exploited for various medicinal applications. EUG has antiviral, antioxidant, and anti-inflammatory functions and several anticancer properties. The objective of this article is to synthesize radioiodinated (131I) EUG and investigate its effect on Caco2, MCF7, and PC3 adenocarcinoma cell lines. It is observed that radioiodinated EUG would have potential on therapy and imaging due to its notable uptakes in studied cells.
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .|2 Department of Chemistry, Faculty of Science, Ege University , Izmir, Turkey .
authors.forename: Emine
authors.initials: E
authors.lastname: Dervis
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
authors.forename: Ayfer
authors.initials: A
authors.lastname: Yurt Kilcar
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
authors.forename: Emin Ilker
authors.initials: EI
authors.lastname: Medine
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
authors.forename: Volkan
authors.initials: V
authors.lastname: Tekin
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .|2 Department of Chemistry, Faculty of Science, Ege University , Izmir, Turkey .
authors.forename: Buse
authors.initials: B
authors.lastname: Cetkin
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
authors.forename: Emre
authors.initials: E
authors.lastname: Uygur
authors.affiliation: 1 Department of Nuclear Applications, Institute of Nuclear Science, Ege University , Izmir, Turkey .
authors.forename: Fazilet Zumrut Biber
authors.initials: FZB
authors.lastname: Muftuler
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy*; D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005054:Eugenol / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000737:chemistry*; D007553:Isotope Labeling; D061986:MCF-7 Cells; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D005054:Eugenol
keywords: Caco2; MCF7; PC3; cancer cell line; eugenol; radioiodination