title: Hyperuricemia at The Time Of Diagnosis is a Factor for Poor Prognosis in Patients With Stage II and III Colorectal Cancer (Uric Acid and Colorectal Cancer)
abstract: Purpose: In this pilot study we investigated whether serum levels of uric acid, the final breakdown product of
  purine metabolism, might influence cancer-related events in stage II and III colorectal cancer patients. Material and
  methods: In this cross-sectional retrospective study, a total of 150 stage II and III colorectal adenocarcinoma patients
  with no exclusion criteria were included. Serum uric acid levels of the patients measured at diagnosis and demographic,
  clinical, laboratory analyses were performed and histologically features recorded. Patients were stratified into quartiles
  according to serum uric acid level with different cut-off values. Results: The mean serum uric acid level of all patients
  was determined o be 6.97±2.87 md/dL (range, 3.1-12.4). Median follow-up time was 98 (range 9-98) months and the
  proportion of patients who did not relapse was 22%. It was determined that majority of the patients who had serum uric
  acid levels over 8.37 mg/dL had stage IIIB lesions, were smokers, were among those who lost weight, with metastasis
  to the liver and with significantly leukocyte and platelet counts. Conclusions: Serum uric acid levels measured at the
  time of diagnosis may be associated
authors.affiliation: Mugla Sitki Kocman University Faculty of Medicine, Department of Internal Medicine, Mugla. Email:mugla.medicaloncology@gmail.com
authors.forename: Ahmet Ozan
authors.initials: AO
authors.lastname: Cetin
authors.forename: Muhyettin
authors.initials: M
authors.lastname: Omar
authors.forename: Serkan
authors.initials: S
authors.lastname: Calp
authors.forename: Hasan
authors.initials: H
authors.lastname: Tunca
authors.forename: Nevin
authors.initials: N
authors.lastname: Yimaz
authors.forename: Burak
authors.initials: B
authors.lastname: Ozseker
authors.forename: Ozgur
authors.initials: O
authors.lastname: Tanriverdi
keywords: Uric acid; colorectal cancer; prognosis