title: Single Units in the Posterior Parietal Cortex Encode Patterns of Bimanual Coordination.
abstract: Bimanual coordination is critical for a broad array of behaviors. Drummers, for example, must carefully coordinate movements of their 2 arms, sometimes beating on the same drum and sometimes on different ones. While coordinated behavior is well-studied, the early stages of planning are not well understood. In the parietal reach region (PRR) of the posterior parietal cortex (PPC), the presence of neurons that modulate when either arm moves by itself has been taken as evidence for a role in bimanual coordination. To test this notion, we recorded neurons during both unilateral and bimanual movements. We find that the activity that precedes an ipsilateral arm movement is primarily a sensory response to a target in the neuron's visual receptive field and not a plan to move the ipsilateral arm. In contrast, the activity that precedes a contralateral arm movement is the sum of a movement plan plus a sensory response. Despite not coding ipsilateral arm movements, about half of neurons discriminate between different patterns of bimanual movements. These results provide direct evidence that PRR neurons represent bimanual reach plans, and suggest that bimanual coordination originates in the sensory-to-motor processing stream prior to the motor cortex, within the PPC.
authors.affiliation: Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Mooshagian
authors.affiliation: Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Cunguo
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Holmes
authors.affiliation: Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA.|Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Snyder
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D005133:Eye Movements; D007839:Functional Laterality / Q000502:physiology*; D006225:Hand / Q000502:physiology*; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male; D015233:Models, Statistical; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000166:cytology* / Q000000981:diagnostic imaging; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D060388:Support Vector Machine; D013997:Time Factors