title: Catalyst-Free Synthesis of Pyrrolo[1,2-a]quinolines via Dehydration/[3 + 2] Cycloaddition Directly from 2-Methylquinolines, Aldehydes, and Alkynoates.
abstract: A simple and efficient catalyst-free synthesis of pyrrolo[1,2-a]quinoline derivatives from 2-methylquinolines, aldehydes, and alkynoates via dehydration/[3 + 2] cycloaddition has been developed. The reaction conditions are tolerant to air, and H2O is the only byproduct of this transformation, thus offering an environmentally benign process with a wide range of potential applications in organic synthesis and medicinal chemistry.
authors.affiliation: College of Pharmacy, Guilin Medical University , Guilin 541004, People's Republic of China.|State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Fu-Song
authors.initials: FS
authors.lastname: Wu
authors.affiliation: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Hai-Yuan
authors.initials: HY
authors.lastname: Zhao
authors.affiliation: College of Pharmacy, Guilin Medical University , Guilin 541004, People's Republic of China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Xu
authors.affiliation: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Hu
authors.affiliation: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Ying-Ming
authors.identifier: 0000-0002-3625-7647
authors.initials: YM
authors.lastname: Pan
authors.affiliation: College of Pharmacy, Guilin Medical University , Guilin 541004, People's Republic of China.
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Ma