title: Emerging roles for the amyloid precursor protein and derived peptides in the regulation of cellular and systemic metabolism.
abstract: The amyloid precursor protein (APP) is a transmembrane protein that can be cleaved by proteases through two different pathways to yield a number of small peptides, each with distinct physiological properties and functions. It has been extensively studied in the context of Alzheimer's disease, with the APP-derived amyloid β (Aβ) peptide being a major constituent of the amyloid plaques observed in this disease. It has been known for some time that APP can regulate neuronal metabolism; however, the present review examines the evidence indicating that APP and its peptides can also regulate key metabolic processes such as insulin action, lipid synthesis and storage and mitochondrial function in peripheral tissues. This review presents the hypothesis that amyloidogenic processing of APP in peripheral tissues plays a key role in the response to nutrient excess and that this could contribute to the pathogenesis of metabolic diseases such as obesity and type 2 diabetes (T2D).
authors.affiliation: Metabolic Research Unit, Metabolic Reprogramming Laboratory, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, VIC, Australia.|Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich-Heine University, Düsseldorf, Germany.|German Center of Diabetes Research, München-Neuherberg, Germany.
authors.forename: J K
authors.initials: JK
authors.lastname: Czeczor
authors.affiliation: Metabolic Research Unit, Metabolic Reprogramming Laboratory, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, VIC, Australia.
authors.forename: S L
authors.identifier: 0000-0001-6953-106X
authors.initials: SL
authors.lastname: McGee
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D007333:Insulin Resistance / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor
keywords: 
  APP
  ; amyloid β; insulin resistance; mitochondria