title: A copper-catalyzed Ritter-type cascade via iminoketene for the synthesis of quinazolin-4(3H)-ones and diazocines.
abstract: We have developed a copper-catalyzed Ritter-type reaction/cyclization cascade of anthranilic acids and nitriles, affording the quinazolin-4(3H)-ones. The cascade proceeds through a Ritter-type reaction capturing the iminoketene intermediates by nitriles. Furthermore, we found a novel Ritter-type reaction/condensation/intramolecular anti-Markovnikov hydroamination cascade, providing access to functionalized diazocines in one-pot.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-tobetsu, Hokkaido 0610293, Japan. abe-t@hoku-iryo-u.ac.jp.
authors.forename: Takumi
authors.identifier: http://orcid.org/0000-0003-1729-1097
authors.initials: T
authors.lastname: Abe
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-tobetsu, Hokkaido 0610293, Japan. abe-t@hoku-iryo-u.ac.jp.
authors.forename: Koshiro
authors.initials: K
authors.lastname: Kida
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-tobetsu, Hokkaido 0610293, Japan. abe-t@hoku-iryo-u.ac.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada