title: VEGF inhibition as possible therapy in spondyloarthritis patients: Targeting bone remodelling.
abstract: Spondyloarthritis refers to a group of chronic inflammatory rheumatic diseases that predominantly affects the axial skeleton, causing pain and stiffness. Human bone is highly dynamic organ that interacts with a wide array cells and tissues. Process of bone remodelling relies on a delicate balance between bone formation and bone resorption, orchestrated by osteoblasts and osteoclasts. Disruption of this homeostatic balance of bone removal and replacement can manifest as inappropriate new bone formation found in spondylarthritis. We hypothesize that VEGF may promote bone remodelling, stimulate angiogenesis, and both osteoclastic and osteoblastic activity. Anti VEGF may be tested as a dedicated therapy to prevent bone remodelling in spondyloarthritis patients, namely in cases of aggressive disease. Bone remodelling could be monitored by using [18F]Fluoride PET scan.
authors.affiliation: Centre d'imagerie Médicale, 47, Boulevard du Pont Rouge, 15000 Aurillac, France. Electronic address: lacout.alexis@wanadoo.fr.
authors.forename: Alexis
authors.initials: A
authors.lastname: Lacout
authors.affiliation: Service de Radiologie, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380 Garches, France. Electronic address: ry.carlier@wanadoo.fr.
authors.forename: Robert Yves
authors.initials: RY
authors.lastname: Carlier
authors.affiliation: Service de Radiologie, Hôpital Ambroise pare (APHP), 9, Avenue Charles De Gaulle, 92100 Boulogne Billancourt, France. Electronic address: elhajjam.mostafa@wanadoo.fr.
authors.forename: Mostafa
authors.initials: M
authors.lastname: El Hajjam
authors.affiliation: Radiodiagnostic and Interventional Radiology Department, Polyclinique Les Fleurs, Quartier Quiez, 83190 Ollioules, France. Electronic address: brozpy@gmail.com.
authors.forename: Pierre Yves
authors.initials: PY
authors.lastname: Marcy
mesh_terms: D016723:Bone Remodeling / Q000187:drug effects*; D001862:Bone Resorption; D006706:Homeostasis; D006801:Humans; D008962:Models, Theoretical; D009389:Neovascularization, Pathologic; D010006:Osteoblasts / Q000187:drug effects; D010010:Osteoclasts / Q000187:drug effects; D049268:Positron-Emission Tomography; D012216:Rheumatic Diseases / Q000628:therapy; D025242:Spondylarthropathies / Q000188:drug therapy*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A
keywords: Angiogenesis; COX2; PET; VEGF