title: Overexpression of chromatin assembly factor-1/p60 predicts biological behaviour of laryngeal carcinomas.
abstract: This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.
authors.affiliation: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mesolella
authors.affiliation: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Iorio
authors.affiliation: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Landi
authors.affiliation: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cimmino
authors.affiliation: Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ilardi
authors.affiliation: Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Iengo
authors.affiliation: Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mascolo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D056504:Chromatin Assembly Factor-1 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D056504:Chromatin Assembly Factor-1
keywords: CAF-1/p60; Carcinoma in situ; Dysplasia; Laryngeal cancer; Prognostic factor; Tumoural marker