title: T Cells in Celiac Disease.
abstract: Celiac disease is a human T cell-mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, this review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease.
authors.affiliation: Department of Medicine, University of Chicago, Chicago, IL 60637; bjabri@bsd.uchicago.edu l.m.sollid@medisin.uio.no.|Department of Pathology, University of Chicago, Chicago, IL 60637.|Department of Pediatrics, University of Chicago, Chicago, IL 60637; and.
authors.forename: Bana
authors.initials: B
authors.lastname: Jabri
authors.affiliation: Department of Immunology, Centre for Immune Regulation, K.G. Jebsen Coeliac Disease Research Centre, University of Oslo and Oslo University Hospital-Rikshospitalet, N-0372 Oslo, Norway bjabri@bsd.uchicago.edu l.m.sollid@medisin.uio.no.
authors.forename: Ludvig M
authors.identifier: 0000-0001-8860-704X
authors.initials: LM
authors.lastname: Sollid
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002446:Celiac Disease / Q000276:immunology*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology