title: The potential DNA toxic changes among workers exposed to antimony trioxide.
abstract: Occupational exposure to antimony has gained much interest when specific toxic effects were noticed among workers processing antimony. Thus, the aim of the present work was to investigate the potential DNA oxidative damage occurring among Egyptian workers occupationally exposed to antimony trioxide. The study was conducted on 25 subjects exposed to antimony trioxide while working in the polymerization process of polyester in Misrayon and Polyester Fiber Company, KafrEldawwar, Beheira, Egypt. Urinary antimony levels were assessed using inductive coupled plasma-optical emission spectrometry (ICP-OES) and considered as a biological exposure index. DNA damage and total oxidant capacity (TOC) were assessed using ELISA. DNA damage was detected in the form of increased apurinic/apyrimidinic (AP) sites among antimony trioxide-exposed workers compared to control subjects, but it could not be explained by oxidative mechanisms due to lack of significant correlation between DNA damage and measured TOC. Antimony trioxide might have a genotoxic impact on occupationally exposed workers which could not be attributed to oxidative stress in the studied cases.
authors.affiliation: Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
authors.forename: Safaa
authors.initials: S
authors.lastname: El Shanawany
authors.affiliation: Department of Industrial Medicine and Occupational Heath, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
authors.forename: Nermine
authors.initials: N
authors.lastname: Foda
authors.affiliation: Department of Clinical and Chemical Pathology, Faculty of Medicine, University of Alexandria, Azarita, Alexandria, Egypt. doaa_hashad2003@yahoo.com.
authors.forename: Doaa I
authors.initials: DI
authors.lastname: Hashad
authors.affiliation: Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
authors.forename: Naglaa
authors.initials: N
authors.lastname: Salama
authors.affiliation: Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
authors.forename: Zahraa
authors.initials: Z
authors.lastname: Sobh
mesh_terms: D000965:Antimony; D004247:DNA; D004249:DNA Damage; D004534:Egypt; D006801:Humans; D016273:Occupational Exposure
chemical_list: D004247:DNA; D000965:Antimony; C037554:antimony trioxide
keywords: Antimony trioxide; DNA damage; Egyptian; Exposure; Oxidative; Workers