title: Successful treatment ofChrysosporiumkeratitis with voriconazole.
abstract: OBJECTIVE
  To report a patient with severeChrysosporiumkeratitis successfully treated by voriconazole.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 37-year-old healthy male presented with irritation, pain and reduced vision in his left eye after mud contamination. Examination demonstrated corneal stromal infiltration, endothelial plaque and hypopyon. Corneal scrapings demonstrated numerous septate hyphae, and specimen cultures were positive forChrysosporiumsp. The lesion did not respond to aggressive topical 5% natamycin, 0.15% topical amphotericin B and oral itraconazole. The patient was then treated by topical 1% voriconazole every hour. Intracameral and intrastromal voriconazole injections (50 μg/0.1 mL) were also undertaken. The keratitis was significantly improved after voriconazole.
  
  
  CONCLUSIONS
  To the best of the authors' knowledge, this is the first report on the use of voriconazole forChrysosporiumkeratitis. Voriconazole may be an effective alternative to conventional antifungal agents in some cases of fungal keratitis. It should be considered before shifting to therapeutic keratoplasty.
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Onsiri
authors.initials: O
authors.lastname: Thanathanee
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Chavakij
authors.initials: C
authors.lastname: Bhoomibunchoo
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Orapin
authors.initials: O
authors.lastname: Anutarapongpan
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Olan
authors.initials: O
authors.lastname: Suwan-Apichon
authors.affiliation: KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Yosanan
authors.initials: Y
authors.lastname: Yospaiboon
keywords: Chrysosporium; keratitis; keratoplasty; voriconazole