title: Synthesis and Evaluation of a64Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent.
abstract: Given the putative selectivity of the antagonist TIPP (Tyr-Tic-Phe-Phe) for δ-opioid receptors (DOP), this compound was selected for the design of a novel64Cu-radiolabeled potent and selective DOP positron emission tomography (PET) imaging agent. Ex vivo autoradiography of TIPPD-PEG-K(NOTA/64Cu)-NH2on rat brain sections produced a distribution pattern consistent with the known expression of DOP. Taken together, the in vitro and ex vivo data indicate that this64Cu-tracer holds promise for studying the DOP by means of PET.
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Pirisedigh
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Véronique
authors.initials: V
authors.lastname: Blais
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Samia
authors.initials: S
authors.lastname: Ait-Mohand
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Khaled
authors.initials: K
authors.lastname: Abdallah
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Holleran
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Richard
authors.initials: R
authors.lastname: Leduc
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Yves L
authors.initials: YL
authors.lastname: Dory
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Louis
authors.identifier: 0000-0002-2058-8863
authors.initials: L
authors.lastname: Gendron
authors.affiliation: Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
authors.forename: Brigitte
authors.identifier: 0000-0002-0319-4512
authors.initials: B
authors.lastname: Guérin