title: Antimicrobial consumption and antimicrobial resistance: a snapshot of an Italian neuromuscular rehabilitation center.
abstract: The paper presents a snapshot of the incidence of antimicrobial-resistant microorganisms and antimicrobial consumption in an Italian rehabilitation center over a two-year period (2014-2015). Data on microorganism identification and antimicrobial susceptibility testing were obtained from the diagnostic laboratory of the hospital. A set of indicators was assessed, including the incidence density of resistant isolates per 1000 patient-days (IDRI). Data on antimicrobial consumption, semi-annually, obtained from the hospital pharmacy, were expressed as Defined Daily Dose (DDD) per 1000 patient-days. The most frequently isolated microorganism was Klebsiella pneumoniae (19.3%), and a significant increase in piperacillin/tazobactam- resistant K. pneumoniae (p=0.04) was observed. Among all antimicrobials used, carbapenems were the most prescribed antibiotic class (31%).
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo", Messina (ME), Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Barberi
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo", Messina (ME), Italy.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: De Cola
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo", Messina (ME), Italy.
authors.forename: De Cola
authors.initials: C
authors.lastname: Dell'Utri
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo", Messina (ME), Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Melardi
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo", Messina (ME), Italy.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Alagna
authors.affiliation: IRCCS Centro Neurolesi "Bonino-Pulejo", Messina (ME), Italy.
authors.forename: Placido
authors.initials: P
authors.lastname: Bramanti
authors.affiliation: Department of Health Promotion Sciences and Mother and Child Care "G. D'Alessandro", University of Palermo, Palermo, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cascio
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000187:drug effects*; D057785:Catheters; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization; D007441:Intubation, Gastrointestinal; D007558:Italy; D009468:Neuromuscular Diseases / Q000534:rehabilitation*; D012047:Rehabilitation Centers; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antimicrobial consumption; Antimicrobial resistance; DDD per 1000 patient-days; Healthcare-associated infections; Rehabilitation hospital