title: Potential role of retinoids in ovarian physiology and pathogenesis of polycystic ovary syndrome.
abstract: Retinoids (retinol and its derivatives) are required for maintaining vision, immunity, barrier function, reproduction, embryogenesis, cell proliferation and differentiation. Furthermore, retinoid signaling plays a key role in initiating meiosis of germ cells of the mammalian fetal ovary. Recently, studies indicated that precise retinoid level regulation in the ovary provides a molecular control of ovarian development, steroidogenesis and oocyte maturation. Besides, abnormal retinoid signaling may be involved in the pathogenesis of polycystic ovary syndrome (PCOS), one of the most common ovarian endocrinopathies in reproductive-aged women worldwide. This review primarily summarizes recent advancements made in investigating the action of retinoid signaling in ovarian physiology as well as the abnormal retinoid signaling in PCOS.
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, China.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, China.
authors.forename: Chunjin
authors.initials: C
authors.lastname: Li
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, China.
authors.forename: Fengge
authors.initials: F
authors.lastname: Wang
authors.affiliation: College of Animal Sciences, Jilin University, Changchun, China. Electronic address: xzhou65@vip.sina.com.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhou
mesh_terms: D005260:Female; D006801:Humans; D010053:Ovary / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D012176:Retinoids / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D012176:Retinoids
keywords: Ovarian physiology; Polycystic ovary syndrome (PCOS); RBP4; Retinoids