title: Does patchouli oil change blood platelet monoamine oxidase-A activity of adult mammals?
abstract: Patchouli oil, an essential aroma oil extracted from patchouli leaf during short-term exposure with five and ten drops either inhibited (at 1 or 2 h) or stimulated (at 4 h) the platelet MAO-A activity depending on the dosages of the aroma oil mainly due to inhibition or stimulation of its Km. The long-term 15 consecutive days exposure (with two or five drops) of patchouli oil, on the other hand, maximally stimulated the platelet MAO-A activity with five drops patchouli oil for 1 h exposure, but further continuation of its exposure with same doses (two or five drops) for 30 consecutive days significantly stimulated (with two drops) and inhibited (with five drops) the platelet MAO-A activity due to stimulation and inhibition respectively of its corresponding both Kmand Vmax. These results thus suggest that this aroma oil exposure may modulate the blood platelet serotonergic regulation depending on the dose, duration, and conditions of exposure.
authors.affiliation: Department of Biochemistry, University of Calcutta, 35, B.C. Road, Kolkata, 700019, India.
authors.forename: Md Fazlul
authors.initials: MF
authors.lastname: Karim
authors.affiliation: Department of Biochemistry, University of Calcutta, 35, B.C. Road, Kolkata, 700019, India.
authors.forename: Soumyabrata
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: Department of Biochemistry, University of Calcutta, 35, B.C. Road, Kolkata, 700019, India. mrinalkp@yahoo.com.
authors.forename: Mrinal K
authors.initials: MK
authors.lastname: Poddar
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D008297:Male; D008322:Mammals; D008995:Monoamine Oxidase / Q000378:metabolism*; D009822:Oils, Volatile / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage; D018515:Plant Leaves / Q000737:chemistry; D000070177:Pogostemon / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009822:Oils, Volatile; D010936:Plant Extracts; D008995:Monoamine Oxidase
keywords: Blood platelet; Monoamine oxidase-A; Patchouli oil