title: Cardioprotection Effects of Sevoflurane by Regulating the Pathway of Neuroactive Ligand-Receptor Interaction in Patients Undergoing Coronary Artery Bypass Graft Surgery.
abstract: This study was designed to identify attractor modules and further reveal the potential biological processes involving in sevoflurane-induced anesthesia in patients treated with coronary artery bypass graft (CABG) surgery. Microarray profile data (ID: E-GEOD-4386) on atrial samples obtained from patients receiving anesthetic gas sevoflurane prior to and following CABG procedure were downloaded from EMBL-EBI database for further analysis. Protein-protein interaction (PPI) networks of baseline and sevoflurane groups were inferred and reweighted according to Spearman correlation coefficient (SCC), followed by systematic modules inference using clique-merging approach. Subsequently,attractmethod was utilized to explore attractor modules. Finally, pathway enrichment analyses for genes in the attractor modules were implemented to illuminate the biological processes in sevoflurane group. Using clique-merging approach, 27 and 36 modules were obtained from the PPI networks of baseline and sevoflurane-treated samples, respectively. By comparing with the baseline condition, 5 module pairs with the same gene composition were identified. Subsequently, 1 out of 5 modules was identified as an attractor based onattractmethod. Additionally, pathway analysis indicated that genes in the attractor module were associated with neuroactive ligand-receptor interaction. Accordingly, sevoflurane might exert important functions in cardioprotection in patients following CABG, partially through regulating the pathway of neuroactive ligand-receptor interaction.
authors.affiliation: Department of Anesthesiology, Southwest Hospital, Chongqing 400038, China.
authors.forename: Jinquan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The People's Hospital of Bishan County, Chongqing 402760, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Anesthesiology, Southwest Hospital, Chongqing 400038, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Southwest Hospital, Chongqing 400038, China.
authors.forename: Xiaojun
authors.identifier: 0000-0002-5271-000X
authors.initials: X
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000758:Anesthesia / Q000379:methods; D018685:Anesthetics, Inhalation / Q000627:therapeutic use*; D019295:Computational Biology; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000503:physiopathology*; D003331:Coronary Vessels / Q000601:surgery*; D020869:Gene Expression Profiling; D006439:Hemodynamics; D006801:Humans; D008024:Ligands; D008738:Methyl Ethers / Q000627:therapeutic use*; D008875:Middle Aged; D015233:Models, Statistical; D020411:Oligonucleotide Array Sequence Analysis; D015742:Propofol / Q000627:therapeutic use; D025941:Protein Interaction Mapping; D060066:Protein Interaction Maps; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008024:Ligands; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol