title: Recent advances in the study of 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2)Inhibitors.
abstract: 11β-Hydroxysteroid dehydrogenase (11β-HSD), which interconverts hormonally active cortisol and inactive cortisone in multiple human tissues, has two distinct isoforms named 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2). 11β-HSD2 is an NAD+-dependent oxidase which lowers cortisol by converting it to cortisone while 11β-HSD1 mainly catalyzes the reduction which converts cortisone into cortisol. Selective inhibition of 11β-HSD2 is generally detrimental to health because the accumulation of cortisol can cause metabolic symptoms such as apparent mineralocorticoid excess (AME), fetal developmental defects and lower testosterone levels in males. There has been some advances on the study of 11β-HSD2 inhibitors and we think it necessary to make a summary of the characteristics and inhibiting properties of latest 11β-HSD2 inhibitors. As another review on 11β-HSD2 inhibitors has been issued on 2011 (see review (Ma et al., 2011)), this mini-review concerns advances during the last 5 years.
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 32500, China. Electronic address: zcc2899@163.com.
authors.forename: Chunchun
authors.initials: C
authors.lastname: Zhou
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 32500, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Ye
authors.affiliation: The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 32500, China.
authors.forename: He
authors.initials: H
authors.lastname: Wu
authors.affiliation: Wenzhou Central Hopital, Wenzhou, Zhejiang 32500, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ye
authors.affiliation: The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 32500, China.
authors.forename: Quanxu
authors.initials: Q
authors.lastname: Chen
mesh_terms: D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000037:antagonists & inhibitors*; D000818:Animals; D006801:Humans
chemical_list: D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2
keywords: 11β-Hydroxysteroid dehydrogenase type 2; Cortisol; Inhibitor; Metabolic symptoms