title: Synthesis and Antitumor Activity of New Group 3 Metallocene Complexes.
abstract: The quest for alternative drugs with respect to the well-knowncis-platin and its derivatives, which are still used in more than 50% of the treatment regimens for patients suffering from cancer, is highly needed. In this context, organometallic compounds, which are defined as metal complexes containing at least one direct covalent metal-carbon bond, have recently been found to be promising anticancer drug candidates. A series of new metallocene complexes with scandium, yttrium, and neodymium have been prepared and characterized. Some of these compounds show a very interesting anti-proliferative activity in triple negative breast cancer cell line (MDA.MB231) and the non-hormone sensitive prostate cancer cell line (DU145). Moreover, the interaction of some of them with biological membranes, evaluated using liposomes as bio-membrane mimetic model systems, seems to be relevant. The biological activity of these compounds, particularly those based on yttrium, already effective at low concentrations on both cancer cell lines, should be taken into account with regard to new therapeutic approaches in anticancer therapy.
authors.affiliation: Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, Potenza 85100, Italy. acaporale@unisa.it.
authors.forename: Angelamaria
authors.initials: A
authors.lastname: Caporale
authors.affiliation: SSD Sperimentazione Animale, Istituto Nazionale Tumori, IRCCS, "Fondazione G. Pascale", Via Mariano Semmola, Napoli 80131, Italy. palma.giuseppe@icloud.com.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Palma
authors.affiliation: Department of Biology and Chemistry, University of Salerno, Via Giovanni Paolo II, 132, Fisciano 84084, Italy. amariconda@unisa.it.
authors.forename: Annaluisa
authors.initials: A
authors.lastname: Mariconda
authors.affiliation: SSD Sperimentazione Animale, Istituto Nazionale Tumori, IRCCS, "Fondazione G. Pascale", Via Mariano Semmola, Napoli 80131, Italy. vitale_84@hotmail.it.
authors.forename: Vitale
authors.initials: V
authors.lastname: Del Vecchio
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University Calabria, Via Pietro Bucci, Arcavacata di Rende 87036, Italy. domenico.iacopetta@unical.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Iacopetta
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University Calabria, Via Pietro Bucci, Arcavacata di Rende 87036, Italy. ortensiailaria.parisi@unical.it.
authors.forename: Ortensia Ilaria
authors.initials: OI
authors.lastname: Parisi
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University Calabria, Via Pietro Bucci, Arcavacata di Rende 87036, Italy. s.sinicropi@unical.it.
authors.forename: Maria Stefania
authors.initials: MS
authors.lastname: Sinicropi
authors.affiliation: Department of Pharmacy, Health and Nutritional Sciences, University Calabria, Via Pietro Bucci, Arcavacata di Rende 87036, Italy. i@unical.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Puoci
authors.affiliation: SSD Sperimentazione Animale, Istituto Nazionale Tumori, IRCCS, "Fondazione G. Pascale", Via Mariano Semmola, Napoli 80131, Italy. c.arra@istitutotumori.na.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Arra
authors.affiliation: Department of Biology and Chemistry, University of Salerno, Via Giovanni Paolo II, 132, Fisciano 84084, Italy. plongo@unisa.it.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Longo
authors.affiliation: Department of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, Potenza 85100, Italy. carmela.saturnino@unibas.it.
authors.forename: Carmela
authors.initials: C
authors.lastname: Saturnino
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009354:Neodymium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012538:Scandium / Q000737:chemistry*; D015019:Yttrium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009354:Neodymium; D015019:Yttrium; D012538:Scandium
keywords: breast cancer; cell membrane permeability; cytotoxic activity; metal complexes; metallocene group 3; prostate cancer