title: A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face.
abstract: BACKGROUND
  A topical healing system containing a combination of active ingredients including a tripeptide and hexapeptide (TriHex Technology™) has been found to stimulate neoelastogenesis and neocollagenesis.
  
  
  OBJECTIVE
  Evaluate the use of the tripeptide/hexapeptide topical system following fractionated CO2laser resurfacing compared to a bland ointment and cream.
  
  
  METHODS
  In this single-blinded, randomized study, 15 female subjects aged 45-70 years underwent laser resurfacing of the face. Subjects were randomized to use of the tripeptide/hexapeptide system (n=10) or a bland dimethicone-based ointment and petrolatum-based cream (n=5) from 3 weeks pre- until 12 weeks postprocedure. A blinded investigator graded erythema, edema, crusting, exudation, and healing on postprocedure days 1, 3, 4, 7, 28, and 84. A photodamage/wrinkle scale was completed on days 28 and 84. Subjects performed symptomatology grading on days 1 through 14 and completed self-assessments at days 28 and 84.
  
  
  RESULTS
  Data from 14 subjects were analyzed. Blinded-investigator-rated healing was better for the tripeptide/hexapeptide system, reaching statistical significance at day 7. The tripeptide/hexapeptide group demonstrated less erythema and exudation during the first postprocedure week, reaching significance at day 3. On days 1 through 14, subjects using the tripeptide/hexapeptide system reported less tenderness and burning/stinging, also reaching significance on day 3. At day 84, subjects using the tripeptide/hexapeptide system reported higher satisfaction and were more likely to recommend the treatment to others.
  
  
  CONCLUSIONS
  Postresurfacing use of a tripeptide/hexapeptide system proved effective and well-tolerated. Subject satisfaction was greater among those using this system, which may indicate an improved patient experience following laser resurfacing.
authors.affiliation: Goldman Butterwick Groff Fabi & Wu Cosmetic Laser Dermatology, San Diego, CA, USA.
authors.forename: Monique J
authors.identifier: http://orcid.org/0000-0001-8967-6258
authors.initials: MJ
authors.lastname: Vanaman Wilson
authors.affiliation: Alliant Dermatology, The Villages, FL, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Bolton
authors.affiliation: Goldman Butterwick Groff Fabi & Wu Cosmetic Laser Dermatology, San Diego, CA, USA.|Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
authors.forename: Sabrina Guillen
authors.initials: SG
authors.lastname: Fabi
mesh_terms: D000287:Administration, Topical; D000368:Aged; D003357:Cosmetic Techniques; D005145:Face; D005260:Female; D006801:Humans; D054020:Lasers, Gas; D008875:Middle Aged; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D016037:Single-Blind Method; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D009842:Oligopeptides
keywords: esthetic medicine; laser treatments; topical therapy; wound healing