title: [A comparative analysis of the informative value of anti-AChR-antibody radioimmunoassay and laser correlation spectroscopy in myasthenia gravis].
abstract: OBJECTIVE
  An aim of the study was to compare informative value of traditional approach (anti-AChR antibody radioimmunoassay) and evaluation of metabolic shifts by laser correlation spectroscopy in myasthenia gravis.
  
  
  METHODS
  The search for the relationship between the disease severity in 77 patients, 12-80 years and the distribution pattern of subfraction serum components revealed three informative zones: 6-15, 27-67, and 127-223 nm.
  
  
  CONCLUSIONS
  In patients without disturbances of vital functions, the contribution of the first zone particles into light scatter increases and that of the third zone particles decreases. Considerable differences attaining the level of statistical significance in zones 6 and 20 nm were revealed in the spectra of serum from patients with myasthenia gravis of the same severity with and without thymoma. This opens prospects for dynamic monitoring of the efficiency of therapy.
authors.affiliation: Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Alchinova
authors.affiliation: Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Yakovenko
authors.affiliation: SFHI Municipal Clinical Hospital No. 51, Moscow City Health Department, Moscow Myasthenia Center, Moscow, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Sidnev
authors.affiliation: SFHI Municipal Clinical Hospital No. 51, Moscow City Health Department, Moscow Myasthenia Center, Moscow, Russia.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Dedaev
authors.affiliation: SFHI Municipal Clinical Hospital No. 51, Moscow City Health Department, Moscow Myasthenia Center, Moscow, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Sanadze
authors.affiliation: Institute of General Pathology and Pathophysiology, Moscow, Russia.
authors.forename: M Yu
authors.initials: MY
authors.lastname: Karganov
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D007834:Lasers; D009157:Myasthenia Gravis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D011863:Radioimmunoassay; D011950:Receptors, Cholinergic / Q000276:immunology*; D013057:Spectrum Analysis; D013945:Thymoma / Q000097:blood
chemical_list: D001323:Autoantibodies; D011950:Receptors, Cholinergic