title: Annulative π-Extension (APEX): Rapid Access to Fused Arenes, Heteroarenes, and Nanographenes.
abstract: The annulative π-extension (APEX) reaction has the potential to have a tremendous impact on the fields of materials science and bioimaging, as well as on the pharmaceutical/agrochemical industries, since it allows access to fused aromatic systems from relatively simple aromatic compounds in a single step. Typically, an APEX reaction facilitates a one-pot π-extension without the need to prefunctionalize the aromatic compounds. This advantageous feature is extremely useful for tuning and modifying molecular properties in the last step of a synthesis. In this Review, the progress and applications of APEX reactions of unfunctionalized arenes and heteroarenes are described.
authors.affiliation: Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.
authors.forename: Hideto
authors.initials: H
authors.lastname: Ito
authors.affiliation: Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.
authors.forename: Kyohei
authors.initials: K
authors.lastname: Ozaki
authors.affiliation: Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.|Institute of Transformative Bio-Molecules (WPI-ITbM) and, JST-ERATO, Itami Molecular Nanocarbon Project, Chikusa, Nagoya, 464-8602, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Itami
keywords: C-H functionalization; annulation; arenes; condensation; heterocycles