title: Development of a prognosis-prediction model incorporating genetic polymorphism with pathologic stage in stage I non-small cell lung cancer: A multicenter study.
abstract: This multicenter study was performed to develop a prognosis-prediction model incorporating genetic polymorphism with pathologic stage for surgically treated non-small cell lung cancer (NSCLC) patients.
  
  
  
  A replication study including 720 patients and a panel of eight single nucleotide polymorphisms (SNPs), which predicted the prognosis of surgically treated NSCLC in our previous study, was conducted. Using the combined cohort of current and previous studies including 1534 patients, a nomogram for predicting overall survival was made using Cox proportional hazards regression.
  
  
  
  Among the eight SNPs, C3 rs2287845, GNB2L1 (alias RACK1), and rs3756585 were significantly associated with overall survival. A nomogram was constructed based on pathologic stage and the genotypes of the two SNPs, and the risk score was calculated for each patient in the combined cohort. Using the prognosis-prediction model, we categorized patients into low, intermediate, and high-risk groups, which had greater accuracy in predictive ability (log-rank statistics = 54.66) than the conventional tumor node metastasis staging (log-rank statistics = 39.56). Next, we generated a prognosis-prediction model for stage I to identify a subgroup of potential candidates for adjuvant chemotherapy. Notably, 97 out of 499 stage IB patients were classified as high-risk patients with a similar prognosis to stage II patients, suggesting the benefit of adjuvant chemotherapy.
  
  
  
  This prognosis-prediction model incorporating genetic polymorphism with pathologic stage may lead to more precise prognostication in surgically resected NSCLC patients. In particular, this model may be useful in selecting a subgroup of stage IB patients who may benefit from adjuvant chemotherapy.
authors.affiliation: Biostatistics Medical Research Collaboration Center, Kyungpook National University Hospital and Kyungpook National University School of Medicine, Daegu, South Korea.
authors.forename: Won Kee
authors.initials: WK
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.|Lung Cancer Center, Kyungpook National University Medical Center, Daegu, South Korea.
authors.forename: Shin Yup
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Jin Eun
authors.initials: JE
authors.lastname: Choi
authors.affiliation: Lung Cancer Center, Kyungpook National University Medical Center, Daegu, South Korea.|Department of Thoracic Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Yangki
authors.initials: Y
authors.lastname: Seok
authors.affiliation: Lung Cancer Center, Kyungpook National University Medical Center, Daegu, South Korea.|Department of Thoracic Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Eung Bae
authors.initials: EB
authors.lastname: Lee
authors.affiliation: Diagnosis and Prediction Biotechnology, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Hyun Cheol
authors.initials: HC
authors.lastname: Lee
authors.affiliation: Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Hyo-Gyoung
authors.initials: HG
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.|Lung Cancer Center, Kyungpook National University Medical Center, Daegu, South Korea.
authors.forename: Seung Soo
authors.initials: SS
authors.lastname: Yoo
authors.affiliation: Diagnosis and Prediction Biotechnology, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Myung Hoon
authors.initials: MH
authors.lastname: Lee
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Seoul National University School of Medicine, Seoul, South Korea.
authors.forename: Sukki
authors.initials: S
authors.lastname: Cho
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Seoul National University School of Medicine, Seoul, South Korea.
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Jheon
authors.affiliation: Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
authors.forename: In Jae
authors.initials: IJ
authors.lastname: Oh
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
authors.forename: Kook Joo
authors.initials: KJ
authors.lastname: Na
authors.affiliation: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea.|Department of Internal Medicine, Catholic University of Daegu College of Medicine, Daegu, South Korea.
authors.forename: Chi Young
authors.initials: CY
authors.lastname: Jung
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Keimyung University School of Medicine, Daegu, South Korea.
authors.forename: Chang-Kwon
authors.initials: CK
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea.
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea.
authors.forename: Min Ki
authors.initials: MK
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.|Lung Cancer Center, Kyungpook National University Medical Center, Daegu, South Korea.|Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012307:Risk Factors
keywords: 
  NSCLC
  ; polymorphism; prognosis; stage; surgery