title: Verrucoid Variant of Invasive Squamous Cell Carcinoma in Oral Submucous Fibrosis: A Clinicopathological Challenge.
abstract: Verrucous carcinoma (VC) is an exophytic, low-grade, well-differentiated variant of squamous cell carcinoma. It is described as a lesion appearing in the sixth or seventh decade of life that has minimal aggressive potential and, in long-standing cases, has been shown to transform into squamous cell carcinoma. Oral submucous fibrosis (OSMF) is a potentially malignant disorder, and about one-third of the affected population develop oral squamous cell carcinoma. The histopathological diagnosis of verrucous carcinoma is challenging, and the interpretation of early squamous cell carcinoma requires immense experience. Here we present a rare case of a 24-year-old male with OSMF transforming to verrucous carcinoma with invasive squamous cell carcinoma. Even though the case had a straightforward clinical diagnosis, the serial sectioning done for pathological diagnosis disclosed the squamous cell carcinoma.
authors.affiliation: Department of Oral Medicine and Radiology, Thai Moogambigai Dental College and Hospital.
authors.forename: Priya
authors.initials: P
authors.lastname: Ramani
authors.affiliation: Department of Oral Medicine and Radiology, Thai Moogambigai Dental College and Hospital.
authors.forename: C
authors.initials: C
authors.lastname: Krithika
authors.affiliation: Department of Oral Pathology, Thai Moogambigai Dental College and Hospital.
authors.forename: R
authors.initials: R
authors.lastname: Ananthalakshmi
authors.affiliation: Department of Oral Medicine and Radiology, Thai Moogambigai Dental College and Hospital.
authors.forename: Mamta
authors.initials: M
authors.lastname: Singaram
authors.affiliation: Department of Oral Medicine and Radiology, Thai Moogambigai Dental College and Hospital.
authors.forename: Praveena
authors.initials: P
authors.lastname: Jagdish
authors.affiliation: Department of Oral Pathology, Thai Moogambigai Dental College and Hospital.
authors.forename: Sunitha
authors.initials: S
authors.lastname: Janardhanan
authors.affiliation: Department of Oral Pathology, Thai Moogambigai Dental College and Hospital.
authors.forename: Sathiyajeeva
authors.initials: S
authors.lastname: Jeevakarunyam
keywords: dysplasia; exophytic growth; invasive squamous cell carcinoma; oral submucous fibrosis; periodic acid schiff (pas); serial sectioning; verrucous carcinoma