title: Treatment Options in Patients Awaiting Liver Transplantation with Hepatocellular Carcinoma and Cholangiocarcinoma.
abstract: Liver transplantation (LT) provides a good chance of cure for selected patients with hepatocellular carcinoma (HCC) and perihilar cholangiocarcinoma (pCCA). Patients with HCC on a waiting list for LT are at risk for tumor progression and dropout. Treatment of HCC with locoregional therapies may lessen dropout due to tumor progression. Strict selection and adherence to the LT criteria for patients with pCCA before and after neoadjuvant chemotherapy are critical for optimal outcome with LT. This article reviews the existing data for the various treatment strategies used for patients with HCC and pCCA awaiting LT.
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 Southwest Archer Road, P.O. Box 100277, Gainesville, FL 32610, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Unzueta
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 Southwest Archer Road, P.O. Box 100277, Gainesville, FL 32610, USA; Liver Transplant Program, Section of Hepatobiliary Diseases (Liver Unit), Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, 1600 Southwest Archer Road, MSB Room M440, Gainesville, FL 32610, USA. Electronic address: roniel.cabrera@medicine.ufl.edu.
authors.forename: Roniel
authors.initials: R
authors.lastname: Cabrera
mesh_terms: D001650:Bile Duct Neoplasms / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000628:therapy*; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000628:therapy*; D016031:Liver Transplantation; D009367:Neoplasm Staging; D018579:Patient Selection; D014850:Waiting Lists
keywords: Bridging; Down-staging; Locoregional therapies; Neoadjuvant therapies; Outcomes