title: Exchange Phenomena in the Electron Paramagnetic Resonance Spectra of the Nitroxyl and Trityl Radicals: Multifunctional Spectroscopy and Imaging of Local Chemical Microenvironment.
abstract: This Feature overviews the basic principles of using stable organic radicals involved in reversible exchange processes as functional paramagnetic probes. We demonstrate that these probes in combination with electron paramagnetic resonance (EPR)-based spectroscopy and imaging techniques provide analytical tools for quantitative mapping of critical parameters of local chemical microenvironment. The Feature is written to be understandable to people who are laymen to the EPR field in anticipation of future progress and broad application of these tools in biological systems, especially in vivo, over the next years.
authors.affiliation: In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University , Morgantown, West Virginia 26506, United States.|Department of Biochemistry, West Virginia University School of Medicine , Morgantown, West Virginia 26506, United States.
authors.forename: Valery V
authors.identifier: 0000-0001-6187-5546
authors.initials: VV
authors.lastname: Khramtsov
authors.affiliation: In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University , Morgantown, West Virginia 26506, United States.|Department of Biochemistry, West Virginia University School of Medicine , Morgantown, West Virginia 26506, United States.
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Bobko
authors.affiliation: In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University , Morgantown, West Virginia 26506, United States.|Department of Biochemistry, West Virginia University School of Medicine , Morgantown, West Virginia 26506, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Tseytlin
authors.affiliation: In Vivo Multifunctional Magnetic Resonance center, Robert C. Byrd Health Sciences Center, West Virginia University , Morgantown, West Virginia 26506, United States.|Department of Biochemistry, West Virginia University School of Medicine , Morgantown, West Virginia 26506, United States.
authors.forename: Benoit
authors.initials: B
authors.lastname: Driesschaert
mesh_terms: D000818:Animals; D060833:Cellular Microenvironment / Q000502:physiology*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D005609:Free Radicals / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry*; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
chemical_list: D005609:Free Radicals; D009589:Nitrogen Oxides; D014320:Triphenylmethyl Compounds; C039900:nitroxyl