title: Effect of Increased Neutrophil-to-Lymphocyte Ratio (NLR) and Decreased Mean Platelet Volume (MPV) Values on Inflammation in Acute Mania.
abstract: BACKGROUND
  The neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) are simple, low-cost, and useful inflammatory markers detected in routine complete blood count (CBC), and their use has recently become widespread. In this study, we aimed to investigate the presence of an inflammatory state in manic patients on the basis of NLR and MPV values.
  
  
  METHODS
  This retrospective study was performed on 76 patients with acute mania who were admitted to the Inpatients Psychiatry Clinic of Afyon Kocatepe University Hospital in Turkey. Diagnoses were based on Diagnostic and Statistical Manuel of Mental disorder (DSM-IV). The control group consisted of 74 healthy individuals recruited from the community. They were age- and sex-matched with the study group.
  
  
  RESULTS
  NLR values of the manic patient group were 2.2±1.4 and those of the control group were 1.6±0.5. NLR values were significantly higher (p=0.004) and MPV values were significantly lower in the manic patient group than in the control group (10.0±1.2 vs. 10.9±2.3, p=0.027).
  
  
  CONCLUSIONS
  Increased NLR and decreased MPV levels may reflect inflammation in manic patients, and inflammation may play a role in the complex pathophysiology of acute mania.
authors.affiliation: Department of Psychiatry, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Mayda
authors.affiliation: Department of Internal Medicine, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ahsen
authors.affiliation: Department of Psychiatry, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey.
authors.forename: Erman
authors.initials: E
authors.lastname: Bağcioğlu
authors.affiliation: Department of Psychiatry, Dumlupınar University School of Medicine, Kütahya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Öztürk
authors.affiliation: Department of Psychiatry, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Bahçeci
authors.affiliation: Department of Psychiatry, Dumlupınar University School of Medicine, Kütahya, Turkey.
authors.forename: Etem
authors.initials: E
authors.lastname: Soyuçok
authors.affiliation: Department of Psychiatry, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Başpinar
authors.affiliation: Department of Internal Medicine, Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey.
authors.forename: Memnune Sena
authors.initials: MS
authors.lastname: Ulu
keywords: Neutrophil-to-lymphocyte ratio; acute mania; mean platelet volume