title: Platform technologies for modern vaccine manufacturing.
abstract: Improved understanding of antigenic components and their interaction with the immune system, as supported by computational tools, permits a sophisticated approach to modern vaccine design. Vaccine platforms provide an effective tool by which strategically designed peptide and protein antigens are modularized to enhance their immunogenicity. These modular vaccine platforms can overcome issues faced by traditional vaccine manufacturing and have the potential to generate safe vaccines, rapidly and at a low cost. This review introduces two promising platforms based on virus-like particle and liposome, and discusses the methodologies and challenges.
authors.affiliation: The University of Queensland, Protein Expression Facility, St Lucia, QLD 4072, Australia.
authors.forename: Hayley K
authors.initials: HK
authors.lastname: Charlton Hume
authors.affiliation: The University of Queensland, Protein Expression Facility, St Lucia, QLD 4072, Australia. Electronic address: l.lua@uq.edu.au.
authors.forename: Linda H L
authors.initials: LHL
authors.lastname: Lua
mesh_terms: D000941:Antigens; D015195:Drug Design; D006801:Humans; D000071497:Immunogenicity, Vaccine; D008081:Liposomes; D013678:Technology, Pharmaceutical / Q000191:economics* / Q000592:standards*; D058425:Vaccines, Virus-Like Particle / Q000008:administration & dosage / Q000191:economics* / Q000592:standards*; D014764:Viral Proteins
chemical_list: D000941:Antigens; D008081:Liposomes; D058425:Vaccines, Virus-Like Particle; D014764:Viral Proteins
keywords: Liposome; Modular; Platform technology; Vaccine design; Virus-like particle