title: Pd/Cu-catalyzed dual C-H bond carbonylation towards the synthesis of fluorazones.
abstract: Pd/Cu catalyzed oxidative dual C-H bond activation/carbonylation still remains a great challenge due to the generation of by-products via C-C bond formation. Herein we developed a straightforward Pd/Cu-catalyzed oxidative dual C-H bond carbonylation process to access biologically and pharmaceutically important fluorazones from easily available N-aryl pyrroles and CO. A wide range of functional groups were well tolerated in this transformation, and O2could be utilized as the only terminal oxidant to promote the oxidative carbonylation process.
authors.affiliation: National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, P. R. China. lmmtmmt@163.com.
authors.forename: Fan
authors.initials: F
authors.lastname: Liao
authors.forename: Renyi
authors.initials: R
authors.lastname: Shi
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Sha
authors.forename: Jianhui
authors.initials: J
authors.lastname: Xia
authors.forename: Weilin
authors.initials: W
authors.lastname: Liao
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei