title: Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery.
abstract: Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%±1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%±2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%±2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Bhandari
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
authors.forename: Harshita
authors.initials: H
authors.lastname: Mishra
authors.affiliation: Department of Wood Science, Mendel University in Brno, Brno, Czech Republic.
authors.forename: Pawan Kumar
authors.initials: PK
authors.lastname: Mishra
authors.affiliation: Department of Wood Science, Mendel University in Brno, Brno, Czech Republic; Institute for Natural Materials Technology, Department of Agrobiotechnology, IFA-Tulln, University of Natural Resources and Life Sciences, Vienna, Austria.
authors.forename: Rupert
authors.initials: R
authors.lastname: Wimmer
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
authors.forename: Farhan J
authors.initials: FJ
authors.lastname: Ahmad
authors.affiliation: Department of Pharmaceutics, Jamia Hamdard, New Delhi, India.
authors.forename: Sushama
authors.initials: S
authors.lastname: Talegaonkar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000069461:Bendamustine Hydrochloride / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D001682:Biological Availability; D002482:Cellulose / Q000737:chemistry*; D003956:Dialysis; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D005260:Female; D005612:Freeze Drying; D006863:Hydrogen-Ion Concentration; D008297:Male; D057139:Nanofibers / Q000737:chemistry*; D017208:Rats, Wistar; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D002482:Cellulose; D000069461:Bendamustine Hydrochloride
keywords: aerogel; bioavailability; cellulose nanofiber; controlled release; floating behavior; gastroretentive; mucoadhesion; swelling behavior