title: Heart Rate and Blood Pressure Centile Curves and Distributions by Age of Hospitalized Critically Ill Children.
abstract: Heart rate (HR) and blood pressure (BP) form the basis for monitoring the physiological state of patients. Although norms have been published for healthy and hospitalized children, little is known about their distributions in critically ill children. The objective of this study was to report the distributions of these basic physiological variables in hospitalized critically ill children. Continuous data from bedside monitors were collected and stored at 5-s intervals from 3,677 subjects aged 0-18 years admitted over a period of 30 months to the pediatric and cardiac intensive care units at a large quaternary children's hospital. Approximately 1.13 billion values served to estimate age-specific distributions for these two basic physiological variables: HR and intra-arterial BP. Centile curves were derived from the sample distributions and compared to common reference ranges. Properties such as kurtosis and skewness of these distributions are described. In comparison to previously published reference ranges, we show that children in these settings exhibit markedly higher HRs than their healthy counterparts or children hospitalized on in-patient wards. We also compared commonly used published estimates of hypotension in children (e.g., the PALS guidelines) to the values we derived from critically ill children. This is a first study reporting the distributions of basic physiological variables in children in the pediatric intensive care settings, and the percentiles derived may serve as useful references for bedside clinicians and clinical trials.
authors.affiliation: Department of Critical Care Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Department of Pediatric Critical Care, Rambam Medical Center, Haifa, Israel.
authors.forename: Danny
authors.initials: D
authors.lastname: Eytan
authors.affiliation: Department of Critical Care Medicine, The Hospital for Sick Children, University of Toronto , Toronto, ON , Canada.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Goodwin
authors.affiliation: Department of Critical Care Medicine, The Hospital for Sick Children, University of Toronto , Toronto, ON , Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Greer
authors.affiliation: Department of Critical Care Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Neuroscience and Mental Health Program, Research Institute, Toronto, ON, Canada.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Guerguerian
authors.affiliation: Department of Critical Care Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Department of Anaesthesia, University of Toronto, Toronto, ON, Canada.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Laussen
keywords: big data; blood pressure; critical care; heart rate; pediatrics; percentiles