title: Living in an adaptive world: Genomic dissection of the genusHomoand its immune response.
abstract: More than a decade after the sequencing of the human genome, a deluge of genome-wide population data are generating a portrait of human genetic diversity at an unprecedented level of resolution. Genomic studies have provided new insight into the demographic and adaptive history of our species,Homo sapiens, including its interbreeding with other hominins, such as Neanderthals, and the ways in which natural selection, in its various guises, has shaped genome diversity. These studies, combined with functional genomic approaches, such as the mapping of expression quantitative trait loci, have helped to identify genes, functions, and mechanisms of prime importance for host survival and involved in phenotypic variation and differences in disease risk. This review summarizes new findings in this rapidly developing field, focusing on the human immune response. We discuss the importance of defining the genetic and evolutionary determinants driving immune response variation, and highlight the added value of population genomic approaches in settings relevant to immunity and infection.
authors.affiliation: Human Evolutionary Genetics Unit, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France.|Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France.|Centre National de la Recherche Scientifique, URA3012, 75015 Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Quach
authors.affiliation: Human Evolutionary Genetics Unit, Department of Genomes and Genetics, Institut Pasteur, 75015 Paris, France quintana@pasteur.fr.|Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France.|Centre National de la Recherche Scientifique, URA3012, 75015 Paris, France.
authors.forename: Lluis
authors.identifier: 0000-0003-2429-6320
authors.initials: L
authors.lastname: Quintana-Murci
mesh_terms: D000220:Adaptation, Biological; D014644:Genetic Variation; D015894:Genome, Human; D006801:Humans; D007109:Immunity; D009154:Mutation; D040641:Quantitative Trait Loci; D012641:Selection, Genetic