title: "What have we GANEd?" A theoretical construct to explain experimental evidence for noradrenergic regulation of sensory signal processing.
abstract: The GANE (glutamate amplifies noradrenergic effects) theory posits a mechanism for amplifying noradrenergic modulatory actions and enhancing the processing of high-priority sensory signals for immediate or future experience-guided action. This theoretical construct is thought provoking with respect to the central processing of high-priority versus low-priority stimuli, but it requires some refinement to account for physiological fluctuations in NE efflux as a function of naturally occurring transitions in behavioral state and the experimentally observed phenomena associated with noradrenergic regulation of sensory signal transfer.
authors.affiliation: Department of Cell Biology and Neuroscience,Rowan University School of Medicine,Stratford,NJ 08084navarra@rowan.eduwaterhouse@rowan.edu.
authors.forename: Rachel
authors.initials: R
authors.lastname: Navarra
authors.affiliation: Department of Cell Biology and Neuroscience,Rowan University School of Medicine,Stratford,NJ 08084navarra@rowan.eduwaterhouse@rowan.edu.
authors.forename: Barry
authors.initials: B
authors.lastname: Waterhouse
mesh_terms: D003071:Cognition / Q000502:physiology*; D018698:Glutamic Acid; D006801:Humans; D009638:Norepinephrine / Q000502:physiology*; D012677:Sensation
chemical_list: D018698:Glutamic Acid; D009638:Norepinephrine