title: TMPL: a database of experimental and theoretical transmembrane protein models positioned in the lipid bilayer.
abstract: Knowing the position of protein structures within the membrane is crucial for fundamental and applied research in the field of molecular biology. Only few web resources propose coordinate files of oriented transmembrane proteins, and these exclude predicted structures, although they represent the largest part of the available models. In this article, we present TMPL (http://www.dsimb.inserm.fr/TMPL/), a database of transmembrane protein structures (α-helical and β-sheet) positioned in the lipid bilayer. It is the first database to include theoretical models of transmembrane protein structures, making it a large repository with more than 11 000 entries. The TMPL database also contains experimentally solved protein structures, which are available as either atomistic or coarse-grained models. A unique feature of TMPL is the possibility for users to update the database by uploading, through an intuitive web interface, the membrane assignments they can obtain with our recent OREMPRO web server.
authors.affiliation: Inserm U1134, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, UMR_S 1134, Paris, France.|Institut National de la Transfusion Sanguine, Paris, France.|Laboratory of Excellence GR-Ex, Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Postic
authors.affiliation: Inserm U1134, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, UMR_S 1134, Paris, France.|Institut National de la Transfusion Sanguine, Paris, France.|Laboratory of Excellence GR-Ex, Paris, France.
authors.forename: Yassine
authors.initials: Y
authors.lastname: Ghouzam
authors.affiliation: Inserm U1134, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, UMR_S 1134, Paris, France.|Institut National de la Transfusion Sanguine, Paris, France.|Laboratory of Excellence GR-Ex, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Etchebest
authors.affiliation: Inserm U1134, Paris, France.|Université Paris Diderot, Sorbonne Paris Cité, UMR_S 1134, Paris, France.|Institut National de la Transfusion Sanguine, Paris, France.|Laboratory of Excellence GR-Ex, Paris, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Gelly
mesh_terms: D030562:Databases, Protein; D008051:Lipid Bilayers; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D000072417:Protein Domains; D017433:Protein Structure, Secondary
chemical_list: D008051:Lipid Bilayers; D008565:Membrane Proteins