title: Collagen Membrane and Immune Response in Guided Bone Regeneration: Recent Progress and Perspectives.
abstract: Collagen is one of the important components of collagen membranes as well as the extracellular matrix (ECM). Most previous studies have focused on combining collagen membranes with various cross-linking agents, grafting materials, and cytokines to enhance their mechanical properties and bioactivities. Moreover, collagen membranes are often designed to minimize foreign body reactions involving macrophages. However, macrophages were recently found to play a pivotal role during bone regeneration based on their polarization into both proinflammatory and anti-inflammatory phenotypes. Because of the abilities to modulate macrophage polarization and mediate the balance of proinflammatory and anti-inflammatory microenvironments, immune-responsive collagen membranes may be an innovative strategy for promoting bone regeneration. Herein, following a brief review of collagen membranes and the background of macrophages, recent modulations and studies of immune-responsive collagen are described to express the potential of collagen interacting with macrophages and the necessity of further studies in the field of immune-responsive collagen membranes.
authors.affiliation: 1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, China .
authors.forename: Chenyu
authors.initials: C
authors.lastname: Chu
authors.affiliation: 1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, China .
authors.forename: Jia
authors.initials: J
authors.lastname: Deng
authors.affiliation: 2 Yantai Zhenghai Bio-Tech, Laboratory of Shandong Province , Yantai, China .
authors.forename: Xianchang
authors.initials: X
authors.lastname: Sun
authors.affiliation: 1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, China .
authors.forename: Yili
authors.initials: Y
authors.lastname: Qu
authors.affiliation: 1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, China .|3 Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University , Chengdu, China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Man
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001696:Biomechanical Phenomena; D001861:Bone Regeneration / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology*; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008566:Membranes
chemical_list: D001672:Biocompatible Materials; D003094:Collagen
keywords: biomaterials; collagen; macrophage; regeneration; tissue engineering