title: Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population.
abstract: Receptor for Advanced Glycation Endproducts (RAGE) is a member of the immunoglobulin superfamily that binds diverse ligands involved in the development of inflammatory damage and diverse chronic diseases including schizophrenia. Here, three single-nucleotide polymorphisms (SNPs) (G82S, -374T/A, and -429T/C) in theRAGEgene were genotyped in 923 patients with schizophrenia and 874 healthy-matched controls in a Han Chinese population using the SNaPshot technique. Additionally, we investigated the association among aforementioned SNPs with the clinical psychotic symptoms of the patients and neurocognitive function. Our study demonstrated that the frequencies of the TC + CC genotypes and the C allele in the -429T/C polymorphism were significantly lower in the patients compared with the controls (p= 0.031 andp= 0.034, resp.). However, the significant effect disappeared when using Bonferroni correction (p= 0.093 andp= 0.102, resp.). And there were no significant differences in the genotype and allele frequencies between the patients and the controls for G82S and -374T/A polymorphisms. Additionally, the -429T/C C allele carriers had marginally higher Symbol coding scores than the subjects with the TT genotypes [p= 0.031 andp(corr) = 0.093]. Our data indicate that theRAGE-429T/C polymorphism may be associated with the susceptibility of schizophrenia.
authors.affiliation: Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
authors.forename: Jiawu
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zuo
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Luo
authors.affiliation: Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
authors.forename: Juda
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China; Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
authors.forename: Bin
authors.identifier: 0000-0002-8943-0140
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China.
authors.forename: Guoda
authors.identifier: 0000-0001-8914-5852
authors.initials: G
authors.lastname: Ma
authors.affiliation: Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, China; Stroke Center, Neurology & Neurosurgery Division, The Clinical Medicine Research Institute & The First Affiliated Hospital, Jinan University, Guangzhou, China.
authors.forename: Keshen
authors.identifier: 0000-0002-1188-816X
authors.initials: K
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology
chemical_list: D000067759:Receptor for Advanced Glycation End Products