title: Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis.
abstract: The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barré syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein. It has been known that oligosaccharides that are covalently linked to viral envelope proteins are crucial in defining host-virus interactions. However, the role of sugars/glycans in exploiting host-immune mechanisms and aiding receptor-mediated virus entry is not well defined. Therefore, this review focuses on host-pathogen interactions to better understand ZIKV pathogenesis.
authors.affiliation: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
authors.forename: Nanda Kishore
authors.initials: NK
authors.lastname: Routhu
authors.affiliation: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA. sid.byrareddy@unmc.edu.|Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. sid.byrareddy@unmc.edu.
authors.forename: Siddappa N
authors.initials: SN
authors.lastname: Byrareddy
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism*; D054884:Host-Pathogen Interactions / Q000502:physiology*; D006801:Humans; D009844:Oligosaccharides / Q000276:immunology / Q000378:metabolism*; D014779:Virus Replication / Q000502:physiology; D000071244:Zika Virus / Q000276:immunology / Q000378:metabolism*; D000071243:Zika Virus Infection / Q000276:immunology / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D009844:Oligosaccharides
keywords: Host-virus interaction; Immunity; Neuropathogenesis; Virus glycosylation; Zika virus