title: Associations of anthropometry and lifestyle factors with HDL subspecies according to apolipoprotein C-III.
abstract: The presence of apoC-III on HDL impairs HDL's inverse association with coronary heart disease (CHD). Little is known about modifiable factors explaining variation in HDL subspecies defined according to apoC-III. The aim was to investigate cross-sectional associations of anthropometry and lifestyle with HDL subspecies in 3,631 participants from the Diet, Cancer, and Health study originally selected for a case-cohort study (36% women; age 50-65 years) who were all free of CHD. Greater adiposity and less activity were associated with higher HDL containing apoC-III and lower HDL lacking apoC-III. Per each 15 cm higher waist circumference, the level of HDL containing apoC-III was 2.8% higher (95% CI: 0.4, 5.3;P= 0.024) and the level of HDL not containing apoC-III was 4.7% lower (95% CI: -6.0, -3.4;P= <0.0001). Associations for physical activity were most robust to multivariable modeling. Each 20 metabolic equivalent task hours per week reported higher physical activity was associated with 0.9% (95% CI: -1.7, -0.1;P= 0.031) lower HDL containing apoC-III and 0.5% higher (95% CI: 0.1, 1.0;P= 0.029) HDL lacking apoC-III. Lower alcohol consumption was associated with lower HDL lacking apoC-III (percent difference per 15 g/day: 1.58 (95% CI: 0.84, 2.32;P= <0.0001). Adiposity and sedentary lifestyle were associated with a less favorable HDL subspecies profile.
authors.affiliation: Departments of Nutrition Harvard T. H. Chan School of Public Health, Boston, MA mkoch@hsph.harvard.edu.
authors.forename: Manja
authors.initials: M
authors.lastname: Koch
authors.affiliation: Departments of Nutrition Harvard T. H. Chan School of Public Health, Boston, MA.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Furtado
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.
authors.forename: Gordon Z
authors.initials: GZ
authors.lastname: Jiang
authors.affiliation: Departments of Nutrition Harvard T. H. Chan School of Public Health, Boston, MA.
authors.forename: Brianna E
authors.initials: BE
authors.lastname: Gray
authors.affiliation: Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA.
authors.forename: Tianxi
authors.initials: T
authors.lastname: Cai
authors.affiliation: Departments of Nutrition Harvard T. H. Chan School of Public Health, Boston, MA.|Channing Division of Network Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
authors.forename: Frank
authors.initials: F
authors.lastname: Sacks
authors.affiliation: Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.affiliation: Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark and Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.affiliation: Departments of Nutrition Harvard T. H. Chan School of Public Health, Boston, MA.|Channing Division of Network Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
authors.forename: Majken K
authors.initials: MK
authors.lastname: Jensen
mesh_terms: D000368:Aged; D000886:Anthropometry; D053305:Apolipoprotein C-III / Q000097:blood*; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D006801:Humans; D008019:Life Style; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires
chemical_list: D053305:Apolipoprotein C-III; D008075:Lipoproteins, HDL
keywords: epidemiology; high density lipoprotein; obesity