title: Relationship between hyperglycemia, antioxidant capacity and some enzymatic and non-enzymatic antioxidants in African patients with type 2 diabetes.
abstract: OBJECTIVE
  Studies demonstrate that free radicals are involved in the pathogenesis of diabetic complications. The aim of this study was to determine the implication of total antioxidant capacity (TAC) and some enzymatic and non-enzymatic antioxidants as suitable biomarkers of diabetic complications risk factors.
  
  
  METHODS
  A total of 90 patients (70 patients with or without diabetic complications +20 normal healthy) were examined by evaluating the level of lipid peroxidation, nitrogen monoxide (NO), fasting blood glucose, glycated haemoglobin (HbA1c), enzymatic and non-enzymatic antioxidants using standard spectrophotometric methods.
  
  
  RESULTS
  The fasting blood glucose and HbA1c levels were respectively 2.05 and 2.32 times higher in the group of patients with diabetes and complications (DPWC) compared to those of healthy persons. A statistically higher level of malondialdehyde (MDA), NO and TAC was observed in a group of patients with diabetes and complications compared to those without complications (DPNC). A significant positive correlation was found between catalase (CAT) and fasting blood glucose while a significant and negative correlation was noted between reduced glutathione (GSH) and fasting blood glucose. Also was noted a significant relationship between HbA1c and other markers of oxidative stress.
  
  
  CONCLUSIONS
  The results suggest that the plasma levels of CAT, TAC and reduced glutathione could give information on the risk of developing complications of diabetes, considering that the modification of these biomarkers levels were associated with oxidative stress.
authors.affiliation: Department of Biochemistry and Physiological Sciences; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon. apieme@yahoo.fr.
authors.forename: Constant Anatole
authors.identifier: http://orcid.org/0000-0003-1602-6494
authors.initials: CA
authors.lastname: Pieme
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
authors.forename: Jérôme Antony
authors.initials: JA
authors.lastname: Tatangmo
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
authors.forename: Gustave
authors.initials: G
authors.lastname: Simo
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
authors.forename: Prosper Cabral
authors.initials: PC
authors.lastname: Biapa Nya
authors.affiliation: Department of Biochemistry and Physiological Sciences; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
authors.forename: Vicky Jocelyne
authors.initials: VJ
authors.lastname: Ama Moor
authors.affiliation: Department of Biochemistry and Physiological Sciences; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
authors.forename: Bruno
authors.initials: B
authors.lastname: Moukette Moukette
authors.affiliation: Department of Biochemistry and Physiological Sciences; Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
authors.forename: Francine
authors.initials: F
authors.lastname: Tankeu Nzufo
authors.affiliation: Department of Biochemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Borgia Legrand
authors.initials: BL
authors.lastname: Njinkio Nono
authors.affiliation: Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box 1364, Yaounde, Cameroon.
authors.forename: Eugene
authors.initials: E
authors.lastname: Sobngwi
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D002163:Cameroon; D002374:Catalase / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005215:Fasting / Q000097:blood; D005260:Female; D005978:Glutathione / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000150:complications; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D002374:Catalase; D005978:Glutathione; D006442:Glycated Hemoglobin; D008315:Malondialdehyde; D009569:Nitric Oxide; D013482:Superoxide Dismutase
keywords: Malondialdehyde; Oxidative stress; Total Antioxidant Capacity; Type 2 diabetes