title: Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer.
abstract: OBJECTIVE
  To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC).
  
  
  METHODS
  From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach's α coefficient, the Spearman correlation test and Wilcoxon rank sum test.
  
  
  RESULTS
  The EORTC QLQ-CR29 showed satisfactory reliability (α > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (α = 0.608). The multitrait scaling analyses showed good convergent (r> 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS ≤ 80; KPS > 80). Body image and most single-item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients.
  
  
  CONCLUSIONS
  The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Lin
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Dong-Wen
authors.initials: DW
authors.lastname: Wu
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Zhou-Huan
authors.initials: ZH
authors.lastname: Xi
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Yun-Shou
authors.initials: YS
authors.lastname: Lin
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Wakana
authors.initials: W
authors.lastname: Fujiwara
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Tian
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Peng
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Ai
authors.initials: A
authors.lastname: Guo
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Le
authors.initials: L
authors.lastname: Luo
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Ling-Ya
authors.initials: LY
authors.lastname: Jiang
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Qia-Qia
authors.initials: QQ
authors.lastname: Li
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Xue-Ying
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zhang
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Hou-Wei
authors.initials: HW
authors.lastname: Xu
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Yang
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Xun-Lin
authors.initials: XL
authors.lastname: Li
authors.affiliation: Jin-Bo Lin, Yi-Xiong Lei, School of Public Health, Guangzhou Medical University, Guangzhou 511436, Guangdong Province, China.
authors.forename: Yi-Xiong
authors.initials: YX
authors.lastname: Lei
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000523:psychology; D001828:Body Image / Q000523:psychology*; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000150:complications / Q000453:epidemiology / Q000523:psychology* / Q000601:surgery; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D011594:Psychometrics / Q000379:methods*; D011788:Quality of Life; D015203:Reproducibility of Results; D054047:Surgical Stomas / Q000009:adverse effects*; D011795:Surveys and Questionnaires
keywords: Colorectal cancer; EORTC QLQ-CR29; Health-related quality of life; Mainland China