title: The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis.
abstract: The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was to use monomeric periostin in a multicenter study to evaluate its efficacy in diagnosing IPF and predicting its progression. To do so, we developed a new periostin kit to detect only monomeric periostin. The subjects consisted of 60 IPF patients in a multicenter cohort study. We applied monomeric periostin, total periostin detected by a conventional kit, and the conventional biomarkers-KL-6, SP-D, and LDH-to diagnose IPF and to predict its short-term progression as estimated by short-term changes of %VC and % DL, CO. Moreover, we compared the fraction ratios of monomeric periostin to total periostin in IPF with those in other periostin-high diseases: atopic dermatitis, systemic scleroderma, and asthma. Monomeric periostin showed the greatest ability to identify IPF comparable with KL-6 and SP-D. Both monomeric and total periostin were well correlated with the decline of %VC and % DL, CO. Clustering of IPF patients into high and low periostin groups proved useful for predicting the short-term progression of IPF. Moreover, the relative ratio of monomeric periostin was higher in IPF than in other periostin-high diseases. Measuring monomeric periostin is useful for diagnosing IPF and predicting its short-term progression. Moreover, the ratio of monomeric periostin to total periostin is elevated in IPF compared to other periostin-high diseases.
authors.affiliation: Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ohta
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.|Department of Respirology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Okamoto
authors.affiliation: Department of Radiology and Center for Diagnostic Imaging, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Kiminori
authors.initials: K
authors.lastname: Fujimoto
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Noriho
authors.initials: N
authors.lastname: Sakamoto
authors.affiliation: Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Saga Medical School, Saga, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, Japan.
authors.forename: Hisako
authors.initials: H
authors.lastname: Kushima
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.affiliation: Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Akasaka
authors.affiliation: Shino-Test Corporation, Sagamihara, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Ono
authors.affiliation: Shino-Test Corporation, Sagamihara, Japan.
authors.forename: Ayami
authors.initials: A
authors.lastname: Kamei
authors.affiliation: Shino-Test Corporation, Sagamihara, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Azuma
authors.affiliation: Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hisako
authors.initials: H
authors.lastname: Matsumoto
authors.affiliation: Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Yamaguchi
authors.affiliation: Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Aihara
authors.affiliation: Department of Radiology, Kinki Central Hospital of Mutual Aid Association of Public Teachers, Itami, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Johkoh
authors.affiliation: Center for Comprehensive Community Medicine, Saga Medical School, Saga, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawaguchi
authors.affiliation: Department of Respirology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Ichiki
authors.affiliation: Department of Respiratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Sagara
authors.affiliation: Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Yufu, Japan.
authors.forename: Jun-Ichi
authors.initials: JI
authors.lastname: Kadota
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hanaoka
authors.affiliation: Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Saga Medical School, Saga, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Hayashi
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
authors.affiliation: Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Hoshino
authors.affiliation: Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Izuhara
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D015415:Biomarkers / Q000097:blood* / Q000737:chemistry; D015815:Cell Adhesion Molecules / Q000097:blood* / Q000737:chemistry; D002460:Cell Line; D015331:Cohort Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C512835:POSTN protein, human