title: A multimodal instrument for real-time in situ study of ultrasound and cavitation mediated drug delivery.
abstract: The development of a multimodal instrument capable of real-time in situ measurements of cavitation activity and effect in tissue mimicking phantoms during ultrasound and cavitation mediated drug delivery experiments is described here. The instrument features an acoustic arm that can expose phantoms to high-intensity focused-ultrasound while measuring cavitation activity and an optical arm that monitors cavitation effect using confocal microscopy. This combination of modalities allows real-time in situ characterisation of drug delivery in tissue and tissue mimicking phantoms during ultrasound and cavitation mediated drug delivery experiments. A representative result, obtained with a tissue mimicking phantom and acoustically activated droplets, is presented here as a demonstration of the instrument's capabilities and potential applications.
authors.affiliation: Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom.
authors.forename: Shuning
authors.identifier: 0000000180078956
authors.initials: S
authors.lastname: Bian
authors.affiliation: Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom.
authors.forename: Anjali
authors.initials: A
authors.lastname: Seth
authors.affiliation: Lein Applied Diagnostics, Reading, United Kingdom.
authors.forename: Dan
authors.identifier: 0000000174307230
authors.initials: D
authors.lastname: Daly
authors.affiliation: Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom.
authors.forename: Robert
authors.initials: R
authors.lastname: Carlisle
authors.affiliation: Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom.
authors.forename: Eleanor
authors.identifier: 0000000333715929
authors.initials: E
authors.lastname: Stride
mesh_terms: D000162:Acoustics; D016503:Drug Delivery Systems; D064847:Multimodal Imaging; D019047:Phantoms, Imaging; D055585:Physical Phenomena; D014463:Ultrasonography