title: Europium-phenolic network coated BaGdF5nanocomposites for tri-modal computed tomography/magnetic resonance/luminescence imaging.
abstract: Multifunctional nanocomposites based on BaGdF5nanoparticles (NPs) and metal phenolic network (MPN) have been engineered as novel contrast agents for potential applications in X-ray computed tomography, magnetic resonance and luminescence imaging. The BaGdF5@MPN nanocomposites were synthesized at room temperature by coating BaGdF5NPs with europium-phenolic network, which was obtained by the coordination of europium (III) with tannic acid (TA). The in vitro cytotoxicity assays against HepG2 cells revealed that the BaGdF5@MPN nanocomposites presented better cytocompatibility and lower cytotoxity than pure BaGdF5NPs. In addition, vivid red and green luminescence can be observed by confocal laser scanning microscope (CLSM) from the BaGdF5@MPN nanocomposites laden HepG2 cells under the excitation of UV (390 nm) and visible light (440 nm), respectively. The longitudinal relaxivity value (r1) of the nanocomposites was 2.457 mM-1s-1. Moreover, the nanocomoposites exhibited X-ray computed tomography (CT) and T1-weighted magnetic resonance (MR) imaging capacities, and the intensities of the enhanced signals of in vitro CT and MR images were proportional to the concentrations of the nanocomposites. These results indicated that the as-prepared BaGdF5@MPN nanocomposites are promising contrast agents for CT/MR/luminescence imaging.
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei, 430062, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Radiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Liang
authors.affiliation: Department of Radiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei, 430062, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei, 430062, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei, 430062, China.
authors.forename: Tianmeng
authors.initials: T
authors.lastname: Yuan
authors.affiliation: Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials; Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan, Hubei, 430062, China. zushunxu@hubu.edu.cn.
authors.forename: Zushun
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China. xuhaibo1120@hotmail.com.
authors.forename: Haibo
authors.initials: H
authors.lastname: Xu
authors.affiliation: Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. ph.li@siat.ac.cn.
authors.forename: Penghui
authors.initials: P
authors.lastname: Li
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D005063:Europium / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D064847:Multimodal Imaging / Q000379:methods*; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; D005063:Europium; D005682:Gadolinium