title: node.dating: dating ancestors in phylogenetic trees in R.
abstract: Phylogenetic trees encode the evolutionary distances between species or populations. With sufficient information, these evolutionary distances can be rescaled over time to provide estimates of the dates of the most recent ancestors of the species. Here we present the R program node.dating, divergence-time analysis software, which uses a maximum-likelihood method to estimate the dates of the internal nodes of a phylogenetic tree.
  
  
  
  node.dating is available as a part of the R v3.30 package ape v4.0 (cran.r-project.org). node.dating is also available in the GitHub repository: https://github.com/brj1/node.dating , along with supplementary software and tests.
  
  
  
  brj1@sfu.ca.
  
  
  
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.|BC Centre for Excellence in HIV/AIDS, Vancouver, Canada.
authors.forename: Bradley R
authors.initials: BR
authors.lastname: Jones
authors.affiliation: BC Centre for Excellence in HIV/AIDS, Vancouver, Canada.|Department of Medicine, University of British Columbia, British Columbia, Canada.|Department of Pathology and Laboratory Medicine, Western University, London, Canada.
authors.forename: Art F Y
authors.initials: AFY
authors.lastname: Poon
mesh_terms: D023281:Genomics / Q000379:methods*; D006678:HIV / Q000235:genetics; D006801:Humans; D016013:Likelihood Functions; D010802:Phylogeny; D012984:Software