title: Reactive Hyperemia Index in Patients on Maintenance Hemodialysis: Cross-sectional Data from a Cohort Study.
abstract: Previous studies suggested that the reactive hyperemia index (RHI) is a promising cardiovascular risk predictor. We aimed to evaluate clinical determinants of RHI and its association with circulating endothelial injury and cardiac markers in hemodialysis patients. Among 368 patients recruited, RHI was evaluated by peripheral arterial tonometry (PAT) on a midweek nondialysis day. Clinical determinants of RHI were explored by multiple stepwise regression analysis and associations between RHI and circulating markers were evaluated by general linear models. The major cause of a failed PAT test was poor signal (82.1%). Intraclass correlation coefficient for reproducibility evaluation was 0.74. Multiple regression analysis showed traditional clinical factors only explained 7% of the variance of natural logarithm RHI (LnRHI) in the patients. In association analyses, LnRHI showed significant positive associations with Von Willebrand factor (vWF) (p = 0.04) and tissue factor (p = 0.047). It also associated positively with troponins (p ≤ 0.02 for both). In conclusion, performance of the PAT test was acceptable in dialysis patients and traditional clinical variables had very limited influence on RHI in these subjects. Among a panel of conventional endothelial injury markers, RHI showed very modest associations with only vWF and tissue factor. RHI associated positively with troponins in the patients.
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Liu
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Meijuan
authors.initials: M
authors.lastname: Meng
authors.affiliation: Department of Statistics Analysis, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Nephrology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: Zhuxing
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Blood Purification, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Xiurong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Hemodialysis, Yijishan Hospital of Wannan Medical College, Wuhu, China.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Hemodialysis, Yijishan Hospital of Wannan Medical College, Wuhu, China.
authors.forename: Chaoqing
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Hemodialysis, Yijishan Hospital of Wannan Medical College, Wuhu, China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, Affiliated Yixing People's Hospital, Jiangsu University, Yixing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chu
authors.affiliation: Department of Nephrology, Affiliated Yixing People's Hospital, Jiangsu University, Yixing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Nephrology, Luan People's Hospital, Luan, China.
authors.forename: Youwei
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D007674:Kidney Diseases / Q000150:complications* / Q000628:therapy; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D015203:Reproducibility of Results; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers