title: Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study.
abstract: The present retrospective study aimed to investigate the mid-term safety and efficacy of hepatectomy combined with microwave ablation of the partial spleen for treatment of liver cancer complicated with hypersplenism. A retrospective analysis was performed on 23 patients who underwent hepatectomy combined with microwave ablation of the partial spleen for liver cancer, complicated with hypersplenism that was secondary to cirrhosis. The splenic and ablated volumes were calculated according to a contrast-enhanced computed tomography scan prior to and 2 weeks after the operation. Complete blood count and liver function tests were examined prior to and following the surgery, and complications and changes in the blood tests were monitored for 6 months. Over this period of investigation, the splenic volume was reduced by a mean value of 34.0%. The levels of serum alanine aminotransferase and aspartate aminotransferase were increased on the first day after the operation (P<0.05), although they recovered to the normal level within 1 week (P<0.05). The total level of bilirubin increased slightly, along with moderately decreased levels of albumin and cholinesterase on the first day, although these changes were not significant compared with the baseline (P>0.05). The white blood cell count was persistently significantly higher compared with the baseline over the course of the 6 months (P>0.05). The platelet count did not increase significantly for the first week after the operation (P>0.05); however, it was revealed to be significantly increased 1 month after the surgery (P<0.05). No significant complications were occurred during the follow-up period. In conclusion, hepatectomy combined with microwave ablation of the spleen was demonstrated to be a safe and effective procedure for patients with liver cancer and hypersplenism in the mid-term.
authors.affiliation: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Han
authors.affiliation: Department of General Surgery, Xuzhou Infectious Diseases Hospital, Xuzhou, Jiangsu 221004, P.R. China.
authors.forename: Feng-Wei
authors.initials: FW
authors.lastname: Kong
authors.affiliation: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Hai
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Jun-Mao
authors.initials: JM
authors.lastname: Liu
authors.affiliation: Department of Interventional Ultrasound, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Medical Imaging, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Chuan-Jun
authors.initials: CJ
authors.lastname: Xu
authors.affiliation: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China.
authors.forename: Yong-Xiang
authors.initials: YX
authors.lastname: Yi
keywords: hepatocellular carcinoma; hypersplenism; microwave ablation