title: Demystifying blood stem cell fates.
abstract: Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.
authors.affiliation: Department of Haematology, Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
authors.forename: Fiona K
authors.initials: FK
authors.lastname: Hamey
authors.affiliation: Department of Haematology, Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.
authors.forename: Berthold
authors.initials: B
authors.lastname: Göttgens
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D006801:Humans; D013234:Stem Cells