title: Population-based stroke and dementia incidence trends: Age and sex variations.
abstract: BACKGROUND
  We discovered a concomitant decline in stroke and dementia incidence rates at a whole population level in Ontario, Canada. This study explores these trends within demographic subgroups.
  
  
  METHODS
  We analyzed administrative data sources using validated algorithms to calculate stroke and dementia incidence rates from 2002 to 2013.
  
  
  RESULTS
  For more than 12 years, stroke incidence remained unchanged among those aged 20 to 49 years and decreased for those aged 50 to 64, 65 to 79, and 80+ years by 22.7%, 36.9%, and 37.9%, respectively. Dementia incidence increased by 17.3% and 23.5% in those aged 20 to 49 and 50 to 64 years, respectively, remained unchanged in those aged 65 to 79 years, and decreased by 15.4% in those aged 80+ years.
  
  
  CONCLUSIONS
  The concomitant decline in stroke and dementia incidence rates may depict how successful stroke prevention has targeted shared risk factors of both conditions, especially at advanced ages where such risk factors are highly prevalent. We lend support for the development of an integrated system of stroke and dementia prevention.
authors.affiliation: Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
authors.forename: Joshua O
authors.initials: JO
authors.lastname: Cerasuolo
authors.affiliation: Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Ivey Business School, Western University, London, Ontario, Canada.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Cipriano
authors.affiliation: Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.
authors.forename: Luciano A
authors.initials: LA
authors.lastname: Sposato
authors.affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
authors.forename: Moira K
authors.initials: MK
authors.lastname: Kapral
authors.affiliation: Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
authors.forename: Jiming
authors.initials: J
authors.lastname: Fang
authors.affiliation: Institute for Clinical Evaluative Sciences, Queen's University, Kingston, Ontario, Canada; Division of Geriatric Medicine, Queen's University, Kingston, Ontario, Canada; Division of Geriatric Medicine, St. Mary's of the Lake Hospital, Kingston, Ontario, Canada.
authors.forename: Sudeep S
authors.initials: SS
authors.lastname: Gill
authors.affiliation: Division of Clinical Pharmacology, Department of Medicine, Western University, London, Ontario, Canada.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Hackam
authors.affiliation: Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada. Electronic address: Vladimir.Hachinski@lhsc.on.ca.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Hachinski
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D018672:Community Health Planning; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017678:Sex Distribution; D020521:Stroke / Q000453:epidemiology*; D055815:Young Adult
keywords: Age; Dementia; Epidemiology; Incidence; Sex; Stroke; Temporal; Trend