title: [Clinical effect of rock salt aerosol therapy in treatment of occupational allergic contact dermatitis].
abstract: Objective:To investigate the clinical effect and safety of rock salt aerosol therapy in the treatment of occupational allergic contact dermatitis.Methods:A total of 65 patients with acute exacerbation of occupational allergic contact dermatitis who were treated in the Outpatient Service and Inpatient Department of our hospital from March 2013 to December 2015 were enrolled and randomly divided into observation group and control group using a random number table. Both groups were givensymptomatic treatment including desensitization, and the patients in the observation group were given rock salt aerosol therapy for 2 courses in addition to the symptomatic treatment. The changes in symptoms, signs, blood eosinophil count, and IgE were observed.Results:There were significant changes in symptom score at the first and second courses of the treatment (P<0.05) , and there was an interaction between time of therapy and grouping (P<0.05) . There was no significant difference in symptom score before treatment between the two groups (P>0.05) , while there were differences at the first and second courses of the treatment (P<0.05) . After the second course of treatment, the observation group had a significantly higher overall response rate than the control group (P<0.05) ; both groups had significant reductions in blood eosinophil count and the observation group had a significantly greater reduction than the control group (P<0.05) . After two courses of treatment, both groups had significant increases in the number of patients with normal IgE (bothP<0.05) , and after the second course of treatment, the observation group had a significantly higher number than the control group (P<0.05) . Both groups had mild adverse events, which did not affect the treatment.Conclusion:In the treatment of occupational allergic contact dermatitis, rock salt aerosol therapy has a certain effect on the recovery of symptoms, signs, blood eosinophil count, and IgE.
authors.affiliation: The Second Hospital of Heilongjiang Province, Harbin 150010, China.
authors.forename: M L
authors.initials: ML
authors.lastname: Sun
authors.forename: L
authors.initials: L
authors.lastname: Song
authors.forename: H M
authors.initials: HM
authors.lastname: Yang
authors.forename: D M
authors.initials: DM
authors.lastname: Shi
authors.forename: Y L
authors.initials: YL
authors.lastname: Bi
mesh_terms: D000336:Aerosols / Q000627:therapeutic use*; D017449:Dermatitis, Allergic Contact / Q000628:therapy*; D009783:Dermatitis, Occupational / Q000628:therapy*; D004804:Eosinophils / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count; D016896:Treatment Outcome
chemical_list: D000336:Aerosols
keywords: Blood eosinophils; Dermatitis, allergic contact; IgE; Rock salt aerosol