title: Gabapentin Does Not Appear to Improve Postoperative Pain and Sleep Patterns in Patients Who Concomitantly Receive Regional Anesthesia for Lower Extremity Orthopedic Surgery: A Randomized Control Trial.
abstract: In recent years, gabapentin has gained popularity as an adjuvant therapy for the treatment of postoperative pain. Numerous studies have shown a decrease in pain score, even with immediate postoperative activity, which is significant for early post-op ambulation and regaining functionality sooner. However, studies have been in conclusive in patients undergoing lower extremity orthopedic surgery. For this reason, we hoped to study the effect of gabapentin on postoperative pain in patients undergoing total knee arthroplasty, total hip arthroplasty, or a hip fracture repair. This was done in the setting of ensuring adequate postoperative analgesia with regional blocks and opioid PCA, as is protocol at our institution. Given the sedative effects of gabapentin and the potential for improving postoperative sleep patterns, we also studied the drug's effect on this aspect of our patient's postoperative course. We utilized the Pittsburg Sleep Quality Index and Visual Analog Scale for pain to obtain a more objective standardized score amongst our study population. Our results indicate that gabapentin does not offer any additional relief in pain or improve sleep habits in patients who have received either a femoral or lumbar plexus block for lower extremity orthopedic surgery. This trial is registered with NCT01546857.
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Department of Acute Pain, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB E-538, Newark, NJ 07101-1709, USA.
authors.forename: Jean Daniel
authors.identifier: 0000-0002-3555-9432
authors.initials: JD
authors.lastname: Eloy
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Department of Acute Pain, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB E-538, Newark, NJ 07101-1709, USA.
authors.forename: Christy
authors.identifier: 0000-0003-3912-2147
authors.initials: C
authors.lastname: Anthony
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Department of Acute Pain, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB E-538, Newark, NJ 07101-1709, USA.
authors.forename: Shawn
authors.initials: S
authors.lastname: Amin
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Department of Acute Pain, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB E-538, Newark, NJ 07101-1709, USA.
authors.forename: Moorice
authors.identifier: 0000-0002-8219-2709
authors.initials: M
authors.lastname: Caparó
authors.affiliation: Department of Orthopedic Surgery, Rutgers New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07101-1709, USA.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Reilly
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Department of Acute Pain, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB E-538, Newark, NJ 07101-1709, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Shulman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D000588:Amines / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use; D019643:Arthroplasty, Replacement / Q000009:adverse effects; D000068579:Celecoxib / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D000077206:Gabapentin; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use; D035002:Lower Extremity / Q000601:surgery; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000209:etiology; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000209:etiology; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000588:Amines; D000700:Analgesics; D000068579:Celecoxib; D003509:Cyclohexanecarboxylic Acids; D052246:Cyclooxygenase 2 Inhibitors; D000077206:Gabapentin; D005680:gamma-Aminobutyric Acid