title: Phosphonate MOFs Composite as Off-On Fluorescent Sensor for Detecting Purine Metabolite Uric Acid and Diagnosing Hyperuricuria.
abstract: The recent discovery of lanthanide organic frameworks (Ln-MOFs) offers the potential for biomarkers or metabolites sensing. This is another field that is closely connected with life science and medicine. In this work, a stable and luminescent phosphonate Ln-MOFs MIL-91(Al:Eu) and its derivatives composite Cu2+@MIL-91(Al:Eu) were synthesized. The rebound of luminescence of Cu2+@MIL-91(Al:Eu) that origin of Eu3+is observed in the presence of uric acid. This On-Off-On pattern is utilized for detecting uric acid, which is the final metabolite of purine. The composite reveals excellent selectivity and sensitivity for sensing uric acid. The detection of uric acid in real urine is also investigated. The effective detection of uric acid and tentative diagnosis of hyperuricuria on the basis of test paper is demonstrated.
authors.affiliation: Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University , Siping Road 1239, Shanghai 200092, P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Lian
authors.affiliation: Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University , Siping Road 1239, Shanghai 200092, P. R. China.
authors.forename: Bing
authors.identifier: http://orcid.org/0000-0002-0216-9454
authors.initials: B
authors.lastname: Yan
mesh_terms: D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry*; D010316:Particle Size; D011687:Purines / Q000737:chemistry* / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism / Q000652:urine*
chemical_list: D005456:Fluorescent Dyes; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D063065:Organophosphonates; D011687:Purines; D014527:Uric Acid; C030985:purine