title: Current update of adoptive immunotherapy using cytokine-induced killer cells to eliminate malignant gliomas.
abstract: The therapeutic outcome for those with malignant glioma is poor, even though diverse therapeutic modalities have been developed. Immunotherapy has emerged as a therapeutic approach for malignant gliomas, making it possible to selectively treat tumors while sparing normal tissue. Here, we review clinical trials of adoptive immunotherapy approaches for malignant gliomas. We also describe a clinical trial that examined the efficacy and safety of autologous cytokine-induced killer (CIK) cells along with concomitant chemoradiotherapy for newly diagnosed glioblastoma. These CIK cells identify and kill autologous tumor cells. This review focuses on the use of adoptive immunotherapy for malignant gliomas and reviews the current literature on the concept of antitumor activity mediated by CIK cells.
authors.affiliation: Department of Neurosurgery, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 471-701, Gyonggi-do, Republic of Korea.
authors.forename: Je Il
authors.initials: JI
authors.lastname: Ryu
authors.affiliation: Department of Neurosurgery, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 471-701, Gyonggi-do, Republic of Korea.
authors.forename: Myung Hoon
authors.initials: MH
authors.lastname: Han
authors.affiliation: Department of Neurosurgery, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 471-701, Gyonggi-do, Republic of Korea.
authors.forename: Jin Hwan
authors.initials: JH
authors.lastname: Cheong
authors.affiliation: Department of Neurosurgery, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 471-701, Gyonggi-do, Republic of Korea.
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 471-701, Gyonggi-do, Republic of Korea.
authors.forename: Choong Hyun
authors.initials: CH
authors.lastname: Kim
mesh_terms: D000818:Animals; D059248:Chemoradiotherapy; D002986:Clinical Trials as Topic; D055612:Cytokine-Induced Killer Cells / Q000276:immunology* / Q000637:transplantation; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005910:Glioma / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D016896:Treatment Outcome
keywords: adoptive immunotherapy; clinical trials; cytokine-induced killer (CIK) cells; cytotoxicity; glioma; immune response