title: Prevention of AMI Induced Ventricular Remodeling: Inhibitory Effects of Heart-Protecting Musk Pill on IL-6 and TNF-Alpha.
abstract: Heart-Protecting Musk Pill (HMP) is a Traditional Chinese Medicine (TCM) that has been used for the prevention and treatment of coronary heart disease in clinic. The current study investigated the effect of HMP on the concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) and observed the relationship between level changes of inflammatory cytokines and ventricular remodeling in rats with acute myocardial infarction (AMI). Animal models of AMI were made by coronary artery ligation in Sprague-Dawley (SD) rats. AMI rats showed increased levels of IL-6 and TNF-α. Treatment with HMP decreases IL-6 and TNF-αconcentrations in rats with AMI. Histopathological and transmission electron microscopic findings were also essentially in agreement with biochemical findings. The results of our study revealed that inflammatory cytokines IL-6 and TNF-αinduce cardiac remodeling in rats after AMI; HMP improves cardiac function and ameliorates ventricular remodeling by downregulating the expression of IL-6 and TNF-αand further suppressing the ultrastructural changes of myocardial cells.
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210023, China.
authors.forename: Wei
authors.identifier: 0000-0001-9418-8988
authors.initials: W
authors.lastname: Cen
authors.affiliation: The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210001, China.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210001, China.
authors.forename: Ning
authors.identifier: 0000-0002-6250-1180
authors.initials: N
authors.lastname: Gu
authors.affiliation: Ganzheitliches Gesundheits Zentrum, 34305 Hessen, Germany.
authors.forename: Ralph
authors.initials: R
authors.lastname: Hoppe