title: Differentiating Leber Hereditary Optic Neuropathy from Normal-Tension Glaucoma.
abstract: Glaucoma is a neurodegenerative disorder characterized by thinning of neuroretinal rim, enlarged cup-to-disc ratio (CDR) and visual field damage. Although raised intraocular pressure is main risk factor for development of glaucoma, it can occur with consistently normal measurements in the intraocular pressure as normal tension glaucoma (NTG). Enlargement of CDR is a classical sign of glaucoma, but it can also result from non-glaucomatous optic neuropathies such as Leber hereditary optic neuropathy (LHON). We describe a case of LHON with increased CDR, discuss its differential diagnosis with NTG and highlight the reasons for misdiagnoses between these two entities.
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas , Campinas, São Paulo, Brazil.
authors.forename: Fernanda Maria Silveira
authors.initials: FM
authors.lastname: Souto
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas , Campinas, São Paulo, Brazil.
authors.forename: José Paulo Cabral
authors.initials: JP
authors.lastname: de Vasconcellos
authors.affiliation: Center for Molecular Biology and Genetic Engineering, University of Campinas , Campinas, São Paulo, Brazil.
authors.forename: Mônica Barbosa
authors.initials: MB
authors.lastname: de Melo
authors.affiliation: Center for Molecular Biology and Genetic Engineering, University of Campinas , Campinas, São Paulo, Brazil.
authors.forename: Edi Lúcia
authors.initials: EL
authors.lastname: Sartorato
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Campinas , Campinas, São Paulo, Brazil.
authors.forename: Frederico Castelo
authors.identifier: 0000-0002-7949-6832
authors.initials: FC
authors.lastname: Moura
keywords: Differential diagnosis; Leber hereditary optic atrophy; low-tension glaucoma