title: The role of ILC2 in hookworm infection.
abstract: Hookworm is a major public health concern, yet still relatively little is known about the immunological responses involved in human infection. Animal studies are mainly confined to using the natural rodent helminth Nippostrongylus brasiliensis as this has been proposed as the most accurate model of hookworm infection in the mouse, with both its life cycle and the immune responses it invokes having been extremely well characterized. In this review, we examine the roles that type 2 innate lymphoid cells (ILC2s) play in immunity and host tolerance to hookworm infection, particularly N. brasiliensis. This includes their role in the initiation and regulation of immune responses, as well as in the resolution and limitation of tissue damage required after an infection with a large organism, such as a helminth.
authors.affiliation: Malaghan Institute of Medical Research, Wellington, New Zealand.
authors.forename: K
authors.initials: K
authors.lastname: Filbey
authors.affiliation: Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Bouchery
authors.affiliation: Malaghan Institute of Medical Research, Wellington, New Zealand.
authors.forename: G
authors.identifier: 0000-0002-5721-0442
authors.initials: G
authors.lastname: Le Gros
mesh_terms: D000723:Ancylostomatoidea / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D006725:Hookworm Infections / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008297:Male; D051379:Mice; D058069:Neglected Diseases / Q000276:immunology / Q000469:parasitology; D009559:Nippostrongylus / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: 
  Necator americanus
  ; Nippostrongylus brasiliensis; hookworm; innate immunity; innate lymphoid cell, cytokine