title: Peripapillary Retinal Nerve Fiber Layer Thickness and the Evolution of Cognitive Performance in an Elderly Population.
abstract: Retinal nerve fiber layer (RNFL) thickness is reduced in Alzheimer's patients. However, whether it is associated with early evolution of cognitive function is unknown. Within 427 participants from the Three-City-Alienor longitudinal population-based cohort, we explored the relationship between peripapillary RNFL thicknesses and the evolution of cognitive performance. RNFL was assessed at baseline by spectral domain optical coherence tomography; cognitive performances were assessed at baseline and at 2 years, with the Mini-Mental State Examination, the Isaacs' set test, and the Free and Cued Selective Reminding Test (FCSRT). Multivariate linear mixed models were performed. The RNFL was not associated with initial cognitive performance. Nevertheless, a thicker RNFL was significantly associated with a better cognitive evolution over time in thefree delayed recall(p= 0.0037) andfree+cued delayed recall(p= 0.0043) scores of the FCSRT, particularly in the temporal, superotemporal, and inferotemporal segments. No associations were found with other cognitive tests. The RNFL was associated with changes in scores that assess episodic memory. RNFL thickness could reflect a higher risk of developing cognitive impairment over time.
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219 , Bordeaux , France.
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Méndez-Gómez
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, Bordeaux, France; University Hospital, Ophthalmology, Bordeaux, France.
authors.forename: Marie-Bénédicte
authors.initials: MB
authors.lastname: Rougier
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, Bordeaux, France; University Hospital, Ophthalmology, Bordeaux, France.
authors.forename: Laury
authors.initials: L
authors.lastname: Tellouck
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, Bordeaux, France; University Hospital, Ophthalmology, Bordeaux, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Korobelnik
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, Bordeaux, France; University Hospital, Ophthalmology, Bordeaux, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Schweitzer
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, Bordeaux, France; University Hospital, Ophthalmology, Bordeaux, France.
authors.forename: Marie-Noëlle
authors.initials: MN
authors.lastname: Delyfer
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219 , Bordeaux , France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, Bordeaux, France; University Hospital, Memory Consultation, CMRR, Bordeaux, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219 , Bordeaux , France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Delcourt
authors.affiliation: University Bordeaux, INSERM, Bordeaux Population Health Research Center, Team LEHA, UMR 1219 , Bordeaux , France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Helmer
keywords: cognition; elderly; episodic memory; optical coherence tomography; retinal nerve fiber layer