title: Fine-particulate matter (PM2.5), a risk factor for rat gestational diabetes with altered blood glucose and pancreatic GLUT2 expression.
abstract: Recent studies have shown an intriguing association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter2 (GLUT2) expression in a gestational diabetes mellitus (GDM) rat model. GDM rats were exposed to a low PM2.5 dose during pregnancy. After exposure, interleukin-6 (IL-6) and blood routine tests (BRT) were detected. Pancreas underwent pathologic examination. The levels of pancreatic homogenate glutathione peroxidase (GSH-Px), methane dicarboxylic aldehyde (MDA) and GLUT2 were detected. There were lower maternal body weight gain and fetal weight in the PM2.5 group. Exposure to PM2.5 caused increased absorbed blastocyst number, higher blood mono-nuclear cells (PBMC), platelets and IL-6 levels. The postprandial blood glucose (PBG) was elevated at most time points after exposure. The pancreas of PM2.5 exposed rats revealed periductal inflammation under pathological examination. The pancreatic GSH-Px significantly reduced and MDA increased in exposed group. The pancreatic GLUT2 expression was decreased after PM2.5 exposure. Our study provides direct evidence that PM2.5 exposure can result in pancreatic pathological changes and glycemic consequences in GDM rats. The oxidative response and inflammation are involved in PM2.5 increased risk of pancreatic impairment and glycemic consequences.
authors.affiliation: a Department of Gynaecology and Obstetrics , The Second Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang Province , P. R. China , Wenzhou, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yi
authors.affiliation: b Department of Urological Surgery , The First Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang Province , P. R. China , Wenzhou, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wei
authors.affiliation: c Department of Gynaecology and Obstetrics , The Second Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang Province , P. R. China , Wenzhou, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Fan
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001772:Blood Cell Count; D001786:Blood Glucose / Q000032:analysis; D016640:Diabetes, Gestational / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005786:Gene Expression Regulation / Q000187:drug effects*; D051273:Glucose Transporter Type 2 / Q000235:genetics / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D007964:Leukocytosis / Q000139:chemically induced; D018811:Maternal Exposure / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D052638:Particulate Matter / Q000633:toxicity*; D011247:Pregnancy; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D013922:Thrombocytosis / Q000139:chemically induced; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D001786:Blood Glucose; D051273:Glucose Transporter Type 2; D015850:Interleukin-6; D052638:Particulate Matter; C495683:Slc2a2 protein, rat; D005979:Glutathione Peroxidase
keywords: Blood glucose; gestational diabetes mellitus; glucose transporter 2; particulate matter