title: The role of metabolic states in development and disease.
abstract: During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some of these metabolic states maintain a constrained program of nutrient utilization, while others providing metabolic flexibility as a means to couple developmental progression with nutrient availability. Here we discuss our understanding of metabolic programs, and how they support specific aspects of animal development. During phases of rapid proliferation a subset of metabolic programs provide the building blocks to support growth. During differentiation, metabolic programs shift to support the unique demands of each tissue. Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism.
authors.affiliation: Department of Embryology, Howard Hughes Medical Institute Labs, Carnegie Institution for Science, Baltimore, MD 21218, United States.
authors.forename: Matthew H
authors.initials: MH
authors.lastname: Sieber
authors.affiliation: Department of Embryology, Howard Hughes Medical Institute Labs, Carnegie Institution for Science, Baltimore, MD 21218, United States. Electronic address: spradling@ciwemb.edu.
authors.forename: Allan C
authors.initials: AC
authors.lastname: Spradling
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D049109:Cell Proliferation; D004330:Drosophila / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism; D008660:Metabolism; D009474:Neurons / Q000378:metabolism; D009866:Oogenesis / Q000502:physiology