title: Is there evidence to support serum antinuclear antibodies testing in women with recurrent implantation failure undergoing in vitro fertilization?
abstract: One of the most challenging aspects of reproductive medicine is the management of recurrent implantation failure. Various investigations, including antinuclear antibodies testing, are performed to seek an explanation and guide treatment. However, is there sufficient evidence or available therapeutic options to support antinuclear antibodies testing? We present a short review on the current literature and an attempt at a systematic review evaluating the association between antinuclear antibodies and recurrent implantation failure to address this question.
authors.affiliation: a School of Medicine , Queen's Medical Centre, University of Nottingham , Nottingham , UK.
authors.forename: Yuuki Charlie Barke
authors.initials: YCB
authors.lastname: Na
authors.affiliation: b Nurture Fertility, East Midlands Fertility Centre , Nottingham , UK.|c Division of Child Health, Obstetrics and Gynaecology, School of Medicine , University of Nottingham , Nottingham , UK.
authors.forename: Sonia
authors.initials: S
authors.lastname: Asif
authors.affiliation: b Nurture Fertility, East Midlands Fertility Centre , Nottingham , UK.|c Division of Child Health, Obstetrics and Gynaecology, School of Medicine , University of Nottingham , Nottingham , UK.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Raine-Fenning
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood*; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000276:immunology / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D017211:Treatment Failure
chemical_list: D000974:Antibodies, Antinuclear
keywords: In vitro fertilization; anti-nuclear antibodies; recurrent implantation failure