title: Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge.
abstract: The blood-brain barrier is a physical and physiological barrier that protects the brain from toxic substances within the bloodstream and helps maintain brain homeostasis. It also represents the main obstacle in the treatment of many diseases of the central nervous system. Among the different approaches employed to overcome this barrier, the use of nanoparticles as a tool to enhance delivery of therapeutic molecules to the brain is particularly promising. There is special interest in the use of magnetic nanoparticles, as their physical characteristics endow them with additional potentially useful properties. Following systemic administration, a magnetic field applied externally can mediate the capacity of magnetic nanoparticles to permeate the blood-brain barrier. Meanwhile, thermal energy released by magnetic nanoparticles under the influence of radiofrequency radiation can modulate blood-brain barrier integrity, increasing its permeability. In this review, we present the strategies that use magnetic nanoparticles, specifically iron oxide nanoparticles, to enhance drug delivery to the brain.
authors.affiliation: Department of Physical Chemistry, Faculty of Pharmacy, University of Barcelona and Institute of Nanoscience and Nanotechnology (IN2UB), Avda. Joan XXIII, 08028 Barcelona, Spain. mabusquetsvinas@ub.edu.
authors.forename: Maria Antònia
authors.initials: MA
authors.lastname: Busquets
authors.affiliation: Department of Physical Chemistry, Faculty of Pharmacy, University of Barcelona and Institute of Nanoscience and Nanotechnology (IN2UB), Avda. Joan XXIII, 08028 Barcelona, Spain. aespargaro@ub.edu.
authors.forename: Alba
authors.initials: A
authors.lastname: Espargaró
authors.affiliation: Department of Physical Chemistry, Faculty of Pharmacy, University of Barcelona and Institute of Nanoscience and Nanotechnology (IN2UB), Avda. Joan XXIII, 08028 Barcelona, Spain. rsabate@ub.edu.
authors.forename: Raimon
authors.initials: R
authors.lastname: Sabaté
authors.affiliation: Department of Physical Chemistry, Faculty of Pharmacy, University of Barcelona and Institute of Nanoscience and Nanotechnology (IN2UB), Avda. Joan XXIII, 08028 Barcelona, Spain. joanestelrich@ub.edu.
authors.forename: Joan
authors.initials: J
authors.lastname: Estelrich
keywords: IONs; blood-brain barrier; magnetic nanoparticles