title: Prenatal screening for chromosomal abnormalities in IVF patients that opted for preimplantation genetic screening/diagnosis (PGS/D): a need for revised algorithms in the era of personalized medicine.
abstract: Obstetricians offer prenatal screening for most common chromosomal abnormalities to all pregnant women including those that had in vitro fertilization (IVF) and preimplantation genetic screening/diagnosis (PGS/D). We propose that free fetal DNA in maternal circulation together with the second trimester maternal serum alfa feto protein (MSAFP) and ultrasound imaging is the best prenatal screening test for chromosomal abnormalities and congenital anomalies in IVF-PGD/S patients because risk estimations from all other prenatal screening algorithms for chromosomal abnormalities depend heavily on maternal age which is irrelevant in PGS/D patients.
authors.affiliation: Rutgers Robert Wood Johnson Medical School, New Brunswick, USA.
authors.forename: Afua
authors.initials: A
authors.lastname: Takyi
authors.affiliation: Perinatal Institute, Jersey Shore University Medical Center, 1944 Route 33, Suite 204, Neptune, NJ, 07753, USA. Joaquin.Santolaya@hackensackmeridian.org.
authors.forename: Joaquin
authors.identifier: http://orcid.org/0000-0003-0840-0423
authors.initials: J
authors.lastname: Santolaya-Forgas
mesh_terms: D000782:Aneuploidy; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008423:Maternal Age; D062145:Maternal Serum Screening Tests; D057285:Precision Medicine / Q000379:methods; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D011296:Prenatal Diagnosis; D000509:alpha-Fetoproteins / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D000509:alpha-Fetoproteins
keywords: Assisted reproductive technologies; IVF; Noninvasive prenatal screening; Preimplantation genetic diagnosis; Preimplantation genetic screening; Prenatal screening for aneuploidy