title: Prevalence of hepatitis B and C and factors for infection and nonimmune in inflammatory bowel disease patients in China.
abstract: OBJECTIVE
  The aims of this study were to investigate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in inflammatory bowel disease (IBD) patients and the risk factors related to the infection and nonimmune status.
  
  
  METHODS
  A retrospective study was carried out at two clinical centers. The prevalence of viral markers and risk factors related to HBV and HCV infection and nonimmune status were analyzed in IBD patients. Age-matched and sex-matched healthy individuals were recruited as the controls.
  
  
  RESULTS
  A total of 980 IBD patients were included in this study. Present and past HBV infection was detected in 41.21% of the IBD group, which was higher than that in the general population (P=0.003). Age older than 30 years (P=0.000), ulcerative colitis (P=0.002), and previous surgery (P=0.039) were found to be significant risk factors for HBV infection in the multivariate analysis. 36.43% of the patients in the IBD group had nonimmune status against HBV, and age less than 40 years (P=0.011) and Crohn's disease (P=0.002) were identified as independent risk factors in the multivariate analysis. The prevalence of HCV infection was low and similar to that of the general population.
  
  
  CONCLUSIONS
  The prevalence of HBV infection in IBD patients in China was higher than that in Europe, USA, and the general population in China, but the prevalence of HCV infection in IBD patients was similar to that in the general population in this study. The frequency of nonimmune status against HBV was high, especially in young Crohn's disease patients, and HBV vaccination should be intensified and have a targeted coverage.
authors.affiliation: aDepartment of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine bDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Dafan
authors.initials: D
authors.lastname: Chen
authors.forename: Shengzheng
authors.initials: S
authors.lastname: Luo
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Ben
authors.forename: Lungen
authors.initials: L
authors.lastname: Lu
authors.forename: Xinjian
authors.initials: X
authors.lastname: Wan
authors.forename: Jianjiong
authors.initials: J
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007108:Immune Tolerance; D016867:Immunocompromised Host; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers