title: Management of Pediatric Malignant Germ Cell Tumors: ICMR Consensus Document.
abstract: With the introduction of cisplatin, the outcome of children with malignant germ cell tumors (MGCT) has improved to nearly 90% 5 year survival. Over the years, through the results of various multinational co-operative trials, the chemotherapy and surgical guidelines for both the gonadal and extra-gonadal MGCTs have been refined to decrease the early and late morbidities and at the same time improve survival. Introduction of risk categorization has further added to this effort. There has been no recommendation on how the children with malignant germ cell tumors should be treated in India. The current manuscript is written with the objective of developing a consensus guideline for practitioners at a National level. Based on extensively reviewed literature and personal experience of the major pediatric oncology centres in India, the ICMR Expert group has made recommendations for management of children with MGCT India.
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India. sandpagr@hotmail.com.
authors.forename: Sandeep
authors.identifier: http://orcid.org/0000-0001-8315-5814
authors.initials: S
authors.lastname: Agarwala
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India.
authors.forename: Aparajita
authors.initials: A
authors.lastname: Mitra
authors.affiliation: Pediatric Hematology Oncology Unit, Department of Pediatrics, Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Bansal
authors.affiliation: Department of Pediatric Hematology & Oncology, Rajiv Gandhi Cancer Institute & Research Center, Delhi, India.
authors.forename: Gauri
authors.initials: G
authors.lastname: Kapoor
authors.affiliation: Department of Pediatric Oncology, Tata Memorial Hospital, Parel, Mumbai, India.
authors.forename: Tushar
authors.initials: T
authors.lastname: Vora
authors.affiliation: Department of Pediatric Oncology, Tata Memorial Hospital, Parel, Mumbai, India.
authors.forename: Maya
authors.initials: M
authors.lastname: Prasad
authors.affiliation: Department of Pediatric Oncology, Tata Memorial Hospital, Parel, Mumbai, India.
authors.forename: Girish
authors.initials: G
authors.lastname: Chinnaswamy
authors.affiliation: Department of Pediatric Oncology, Tata Memorial Hospital, Parel, Mumbai, India.
authors.forename: Brijesh
authors.initials: B
authors.lastname: Arora
authors.affiliation: Department of Medical Oncology and Pediatric Oncology, Cancer Institute (W.I.A), Adyar, Chennai, India.
authors.forename: Venkatraman
authors.initials: V
authors.lastname: Radhakrishnan
authors.affiliation: Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Laskar
authors.affiliation: NCD Division, Indian Council of Medical Research (ICMR), New Delhi, India.
authors.forename: Tanvir
authors.initials: T
authors.lastname: Kaur
authors.affiliation: NCD Division, Indian Council of Medical Research (ICMR), New Delhi, India.
authors.forename: Rupinder Singh
authors.initials: RS
authors.lastname: Dhaliwal
authors.affiliation: Dr. B.R.A Institute-Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: G K
authors.initials: GK
authors.lastname: Rath
authors.affiliation: Department of Medical Oncology, Dr. B.R.A Institute-Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy
keywords: Diagnosis; Indian context; Malignant germ cell tumors; Treatment