title: Two new polyhydroxyl polyacetylenes from fruits of Herpetospermum caudigerum.
abstract: Two new polyhydroxy polyacetylenes, herpecaudenes A and B (1 and 2), were isolated from the ethanol extract of fruits of Herpetospermum caudigerum, an important Tibetan medicine. The structures of them were elucidated on the basis of extensive spectroscopic methods including UV, IR, HRESIMS,1H and13C NMR, HMBC, HSQC, and1H-1H COSY. Compound 2 showed significant inhibitory effects on NO production in LPS-activated RAW 264.7 macrophages with IC50values of 7.05 ± 1.59 µM.
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.|Tibetanmedicine Institute, China Tibetology Research Center, Beijing, 100101, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Feng
authors.affiliation: Tibetanmedicine Institute, China Tibetology Research Center, Beijing, 100101, China.
authors.forename: Gejia
authors.initials: G
authors.lastname: Zhong
authors.affiliation: Tibetanmedicine Institute, China Tibetology Research Center, Beijing, 100101, China.
authors.forename: Daji
authors.initials: D
authors.lastname: Dengba
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.affiliation: School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China. dushouying@263.net.
authors.forename: Shouying
authors.initials: S
authors.lastname: Du
mesh_terms: D000818:Animals; D051379:Mice; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019662:Cucurbitaceae / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D038861:Medicine, Tibetan Traditional; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D053279:Polyynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000067996:RAW 264.7 Cells; D012639:Seeds / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; C000625120:herpecaudene A; C000625121:herpecaudene B; D009569:Nitric Oxide; D010936:Plant Extracts; D053279:Polyynes
keywords: Herpetospermum caudigerum; NO production; Polyacetylene; Tibetan medicine