title: Leukocyte immunoglobulin-like receptors in human diseases: an overview of their distribution, function, and potential application for immunotherapies.
abstract: Myeloid-derived suppressor cells (MDSCs), a population of immature myeloid cells expanded and accumulated in tumor-bearing mice and in patients with cancer, have been shown to mediate immune suppression and to promote tumor progression, thereby, posing a major hurdle to the success of immune-activating cancer therapies. MDSCs, like their healthy counterparts, such as monocytes/macrophages and granulocytes, express an array of costimulatory and coinhibitory molecules as well as myeloid activators and inhibitory receptors, such as leukocyte immunoglobulin-like receptors (LILR) A and B. This review summarizes current findings on the LILR family members in various diseases, their potential roles in the pathogenesis, and possible strategies to revert or enhance the suppressive function of MDSCs for the benefit of patients by targeting LILRs.
authors.affiliation: Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai, New York, New York, USA.
authors.forename: Jilu
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai, New York, New York, USA.
authors.forename: Sunny
authors.initials: S
authors.lastname: Mai
authors.affiliation: Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai, New York, New York, USA.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Chen
authors.affiliation: Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai, New York, New York, USA.
authors.forename: Kyeongah
authors.initials: K
authors.lastname: Kang
authors.affiliation: Immunobiology & Transplant Science Center, Houston Methodist Hospital, Texas Medical Center, Houston, Texas, USA.|Department of Surgery, Weill Cornell Medical College, Cornell University, New York, New York, USA.
authors.forename: Xian Chang
authors.initials: XC
authors.lastname: Li
authors.affiliation: Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai, New York, New York, USA.|Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai, New York, New York, USA; and.|Department of General Surgery, Icahn School of Medicine, Mount Sinai, New York, New York, USA.
authors.forename: Shu-Hsia
authors.initials: SH
authors.lastname: Chen
authors.affiliation: Department of Oncological Sciences, Icahn School of Medicine, Mount Sinai, New York, New York, USA; ping-ying.pan@mssm.edu.|Tisch Cancer Institute, Icahn School of Medicine, Mount Sinai, New York, New York, USA; and.
authors.forename: Ping-Ying
authors.initials: PY
authors.lastname: Pan
mesh_terms: D000818:Animals; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D000072737:Myeloid-Derived Suppressor Cells / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology*; D019139:Tumor Escape / Q000276:immunology
chemical_list: D011971:Receptors, Immunologic
keywords: MDSCs; autoimmunity; cancer; infection; transplant tolerance