title: Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology.
abstract: Mather and colleagues present an impressive interdisciplinary model of arousal-induced norepinephrine release and its role in selectively enhancing/inhibiting perception, attention, and memory consolidation. This model will require empirical investigation to test its validity and generalizability beyond classic norepinephrine circuits because it simplifies extremely complex and heterogeneous actions including norepinephrine mechanisms related to higher cognitive circuits and psychopathology.
authors.affiliation: Clinical Neurosciences Division,VA National Center for PTSD,VA Connecticut Healthcare System,West Haven,CT 06516.
authors.forename: Chadi G
authors.initials: CG
authors.lastname: Abdallah
authors.affiliation: Clinical Neurosciences Division,VA National Center for PTSD,VA Connecticut Healthcare System,West Haven,CT 06516.
authors.forename: Lynnette A
authors.initials: LA
authors.lastname: Averill
authors.affiliation: Clinical Neurosciences Division,VA National Center for PTSD,VA Connecticut Healthcare System,West Haven,CT 06516.
authors.forename: John H
authors.initials: JH
authors.lastname: Krystal
authors.affiliation: Clinical Neurosciences Division,VA National Center for PTSD,VA Connecticut Healthcare System,West Haven,CT 06516.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Southwick
authors.affiliation: Clinical Neurosciences Division,VA National Center for PTSD,VA Connecticut Healthcare System,West Haven,CT 06516.
authors.forename: Amy F T
authors.initials: AF
authors.lastname: Arnsten
mesh_terms: D001143:Arousal; D003071:Cognition; D018698:Glutamic Acid / Q000502:physiology*; D006801:Humans; D001523:Mental Disorders; D009638:Norepinephrine / Q000502:physiology*
chemical_list: D018698:Glutamic Acid; D009638:Norepinephrine