title: Two new triterpenes from Euphorbia alatavica.
abstract: A phytochemical investigation on Euphorbia alatavica Boiss resulted in the isolation of nine compounds, including two new ones, alatavolide and alatavoic acid (1-2). Chemical structures of these compounds were established on the basis of 1D, 2D NMR, and HR-MS techniques, and by comparison with data reported in the literature. Compounds 1, 2, 4, 6, 8, and 9 were screened for cytotoxicity using the MTT assay. Among these compounds, the new compound 2 showed moderate cytotoxicity against Hela, MCF-7 and A549 cell lines (IC50values of 16.4 ± 3.2, 14.5 ± 2.8, 22.3 ± 3.1 μM, respectively), while the known compound 8 exhibited the most potent cytotoxicity with the IC50values of 6.5 ± 3.1, 1.9 ± 0.9, 8.6 ± 3.5 μM, respectively.
authors.affiliation: a Key Laboratory of Plant Resources and Chemistry of Arid Zone , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.|c University of the Chinese Academy of Sciences , Beijing 100039 , China.
authors.forename: Rushangul
authors.initials: R
authors.lastname: Rozimamat
authors.affiliation: b State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Nurmuhammat
authors.initials: N
authors.lastname: Kehrimen
authors.affiliation: a Key Laboratory of Plant Resources and Chemistry of Arid Zone , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: b State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Ma
authors.affiliation: a Key Laboratory of Plant Resources and Chemistry of Arid Zone , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.|b State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
authors.forename: Haji Akber
authors.initials: HA
authors.lastname: Aisa
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; C000623063:alatavoic acid; C000623062:alatavolide; D004317:Doxorubicin
keywords: Euphorbia alatavica; bioactivity; triterpene