title: Is Single-Molecule Fluorescence Spectroscopy Ready To Join the Organic Chemistry Toolkit? A Test Case Involving Click Chemistry.
abstract: Single molecule spectroscopy (SMS) has matured to a point where it can be used as a convenient tool to guide organic synthesis and drug discovery, particularly applicable to catalytic systems where questions related to homogeneous vs heterogeneous pathways are important. SMS can look at intimate mechanistic details that can inspire major improvements of the catalyst performance, its recovery, and reuse. Here, we use the click reaction between alkynes and azides as an example where improvements at the bench have been inspired and validated using single-molecule fluorescence spectroscopy.
authors.affiliation: Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation (CCRI), University of Ottawa . 10 Marie Curie, Ottawa, ON K1N 6N5, Canada.
authors.forename: Juan C
authors.identifier: 0000-0002-4838-7123
authors.initials: JC
authors.lastname: Scaiano
authors.affiliation: Department of Chemistry and Biomolecular Sciences and Centre for Catalysis Research and Innovation (CCRI), University of Ottawa . 10 Marie Curie, Ottawa, ON K1N 6N5, Canada.
authors.forename: Anabel E
authors.identifier: 0000-0002-6743-0940
authors.initials: AE
authors.lastname: Lanterna