title: Drug Development Against Metastatic Cancers.
abstract: While combinational diagnostic and treatment strategies over the past decades have significantly improved the overall survival of cancer patients, metastatic cancer remains a leading cause of death in developed countries. The lack of successful treatment strategies for the disease is in large part due to the complexity of the metastatic transformation, which embodies extensive cellular and extracellular alterations, enabling metastatic cancer cells to reach and colonize other organs. The mode of action for the majority of anti-cancer drugs used in clinics today is primarily tumor growth inhibition. While they are effective in destroying cancer cells, they fall short in blocking metastasis. Here we discuss the evolution of past and current anti-cancer drug development, the limits of current strategies, and possible alternative approaches for future drug development against metastatic cancers.
authors.affiliation: Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL.
authors.forename: Sui
authors.initials: S
authors.lastname: Huang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
keywords: anti-cancer drugs; anti-metastasis; metastasis; treatment strategies