title: Phorbol ester-type diterpenoids from the twigs and leaves of Croton tiglium.
abstract: Phytochemical investigation of the ethanol extract from the twigs and leaves of Croton tiglium led to the isolation of two new phorbol esters (1-2) and seven known ones (3-9). Their structures were elucidated by the analyses of extensive spectroscopic data (IR, MS, and 1D and 2D NMR) and comparing with related compounds. Meanwhile, compounds 1-9 were determined for their cytotoxic activities on human lung cancer cell line A549. Among them, 1-2 were inactive against the cell line A549 (IC50> 100 μM), but compounds 3 and 7 showed weak activities.
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Si-Qi
authors.initials: SQ
authors.lastname: Jiang
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Yi-Duo
authors.initials: YD
authors.lastname: Zhou
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Ding
authors.initials: D
authors.lastname: Luo
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Qian-Wen
authors.initials: QW
authors.lastname: Niu
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Yi-Rui
authors.initials: YR
authors.lastname: Qian
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.affiliation: a College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products , Jinan University , Guangzhou 510632 , China.|b Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research , Jinan University , Guangzhou 510632 , China.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010703:Phorbol Esters / Q000191:economics / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry*
chemical_list: C000625132:12-O-isobutyrylphorbol-13-decanoate; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010703:Phorbol Esters
keywords: Croton tiglium; Euphorbiaceae; cytotoxic activity; phorbol esters