title: Thyroid hormone disorders and sepsis.
abstract: Sepsis is a systemic inflammatory response syndrome with high mortality, which results from severe infection and can lead to secondary organ dysfunction. It is one of the most common cause of death in intensive care unit. Clinical reports have shown that sepsis was often accompanied by thyroid dysfunction, which is called "low triiodothyronine (T3)" syndrome and characterized by decreased blood total T3 and free T3, and by normal or decreased thyroxine (T4) and thyroid stimulating hormone (TSH). This syndrome may greatly affect the prognosis of patients with sepsis. The main purpose of this review is to illustrate the role of thyroid hormone disorder in the development and prognosis of sepsis.
authors.affiliation: Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, 430071, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Luo
authors.affiliation: Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430071, P.R. China.
authors.forename: Zhui
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, 430071, P.R. China.
authors.forename: Yinping
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D006321:Heart / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000276:immunology / Q000503:physiopathology; D009206:Myocardium / Q000276:immunology; D011379:Prognosis; D018805:Sepsis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000032:analysis / Q000097:blood / Q000276:immunology*; D014284:Triiodothyronine / Q000032:analysis / Q000097:blood / Q000276:immunology
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine
keywords: Sepsis; low T3 syndrome; organ dysfunction; thyroid hormone