title: The history of rabies in the Western Hemisphere.
abstract: Before the introduction of control programs in the 20th century, rabies in domestic dogs occurred throughout the Western Hemisphere. However, historical records and phylogenetic analysis of multiple virus isolates indicate that, before the arrival of the first European colonizers, rabies virus was likely present only in bats and skunks. Canine rabies was either rare or absent among domestic dogs of Native Americans, and first arrived when many new dog breeds were imported during the period of European colonization. The introduction of the cosmopolitan dog rabies lyssavirus variant and the marked expansion of the dog population provided ideal conditions for the flourishing of enzootic canine rabies. The shift of dog-maintained viruses into gray foxes, coyotes, skunks and other wild mesocarnivores throughout the Americas and to mongooses in the Caribbean has augmented the risk of human rabies exposures and has complicated control efforts. At the same time, the continued presence of bat rabies poses novel challenges in the absolute elimination of canine and human rabies. This article compiles existing historical and phylogenetic evidence of the origins and subsequent dynamics of rabies in the Western Hemisphere, from the era preceding the arrival of the first European colonizers through the present day. A companion article reviews the current status of canine rabies control throughout the Western Hemisphere and steps that will be required to achieve and maintain its complete elimination (Velasco-Villa et al., 2017).
authors.affiliation: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, 30329, GA, USA. Electronic address: DLY3@CDC.GOV.
authors.forename: Andres
authors.initials: A
authors.lastname: Velasco-Villa
authors.affiliation: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, 30329, GA, USA; Oak Ridge Institute for Science and Education (ORISE), CDC Fellowship Program, Oak Ridge, TN, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Mauldin
authors.affiliation: Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.
authors.forename: Mang
authors.initials: M
authors.lastname: Shi
authors.affiliation: Department of Fisheries, Wildlife and Conservation Biology, University of Minnesota, Saint Paul, 55108, MN, USA.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Escobar
authors.affiliation: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, 30329, GA, USA.
authors.forename: Nadia F
authors.initials: NF
authors.lastname: Gallardo-Romero
authors.affiliation: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, 30329, GA, USA.
authors.forename: Inger
authors.initials: I
authors.lastname: Damon
authors.affiliation: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, 30329, GA, USA.
authors.forename: Victoria A
authors.initials: VA
authors.lastname: Olson
authors.affiliation: Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Graham Kerr Building, Glasgow, G12 8QQ, Scotland, UK; MRC-University of Glasgow Centre for Virus Research, Sir Henry Wellcome Building, Glasgow, G61 1QH, Scotland, UK.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Streicker
authors.affiliation: Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Atlanta, 30329, GA, USA.
authors.forename: Ginny
authors.initials: G
authors.lastname: Emerson
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000821:virology; D002417:Cattle; D002487:Centers for Disease Control and Prevention, U.S.; D002685:Chiroptera / Q000821:virology; D004283:Dog Diseases / Q000453:epidemiology / Q000266:history / Q000821:virology; D004285:Dogs; D005060:Europe / Q000453:epidemiology; D005589:Foxes / Q000821:virology; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D018114:Lyssavirus / Q000235:genetics / Q000302:isolation & purification; D010802:Phylogeny; D011159:Population Surveillance; D011634:Public Health / Q000266:history / Q000706:statistics & numerical data; D011818:Rabies / Q000453:epidemiology* / Q000266:history / Q000635:transmission / Q000662:veterinary; D011820:Rabies virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014481:United States / Q000453:epidemiology; D015047:Zoonoses