title: ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms.
abstract: OBJECTIVE
  To develop a risk score that estimates 3-year and 5-year absolute risks for aneurysm growth.
  
  
  METHODS
  From 10 cohorts of patients with unruptured intracranial aneurysms and follow-up imaging, we pooled individual data on sex, population, age, hypertension, history of subarachnoid hemorrhage, and aneurysm location, size, aspect ratio, and shape but not on smoking during follow-up and family history of intracranial aneurysms in 1,507 patients with 1,909 unruptured intracranial aneurysms and used aneurysm growth as outcome. With aneurysm-based multivariable Cox regression analysis, we determined predictors for aneurysm growth, which were presented as a risk score to calculate 3-year and 5-year risks for aneurysm growth by risk factor status.
  
  
  RESULTS
  Aneurysm growth occurred in 257 patients (17%) and 267 aneurysms (14%) during 5,782 patient-years of follow-up. Predictors for aneurysm growth were earlier subarachnoid hemorrhage, location of the aneurysm, age >60 years, population, size of the aneurysm, and shape of the aneurysm (ELAPSS). The 3-year growth risk ranged from <5% to >42% and the 5-year growth risk from <9% to >60%, depending on the risk factor status.
  
  
  CONCLUSIONS
  The ELAPSS score consists of 6 easily retrievable predictors and can help physicians in decision making on the need for and timing of follow-up imaging in patients with unruptured intracranial aneurysms.
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands. D.Backes-2@umcutrecht.nl.
authors.forename: Daan
authors.initials: D
authors.lastname: Backes
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Gabriel J E
authors.initials: GJE
authors.lastname: Rinkel
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Jacoba P
authors.initials: JP
authors.lastname: Greving
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Birgitta K
authors.initials: BK
authors.lastname: Velthuis
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Murayama
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takao
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Ishibashi
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Michiya
authors.initials: M
authors.lastname: Igase
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Karel G
authors.initials: KG
authors.lastname: terBrugge
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Ronit
authors.initials: R
authors.lastname: Agid
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Juha E
authors.initials: JE
authors.lastname: Jääskeläinen
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Antti E
authors.initials: AE
authors.lastname: Lindgren
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Timo
authors.initials: T
authors.lastname: Koivisto
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Mikael
authors.initials: M
authors.lastname: von Und Zu Fraunberg
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Shunji
authors.initials: S
authors.lastname: Matsubara
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Junta
authors.initials: J
authors.lastname: Moroi
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: George K C
authors.initials: GKC
authors.lastname: Wong
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Abrigo
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Keiji
authors.initials: K
authors.lastname: Igase
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Marieke J H
authors.initials: MJH
authors.lastname: Wermer
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Marianne A A
authors.initials: MAA
authors.lastname: van Walderveen
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Ale
authors.initials: A
authors.lastname: Algra
authors.affiliation: From the Department of Neurology and Neurosurgery (D.B., G.J.E.R., A.A., M.D.I.V.), Brain Centre Rudolf Magnus, Julius Centre for Health Sciences and Primary Care (J.P.G., A.A.), and Department of Radiology (B.K.V.), University Medical Centre Utrecht, the Netherlands; Division of Endovascular Neurosurgery (Y.M., H.T., T.I.), Department of Neurosurgery, Jikei University School of Medicine, Tokyo; Department of Geriatrics and Neurology (M.I.), Ehime University School of Medicine, Toon City, Japan; Division of Neuroradiology (K.G.t.B., R.A.), Department of Medical Imaging, Toronto Western Hospital, Ontario, Canada; Department of Neurosurgery (J.E.J., A.E.L., T.K., M.v.u.z.F.), NeuroCenter, Kuopio University Hospital, and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland; Department of Neurosurgery (S.M.), Kawasaki Medical School Hospital, Kurashiki City; Department of Surgical Neurology (J.M.), Research Institute for Brain and Blood Vessels, Akita, Japan; Division of Neurosurgery and Department of Imaging and Interventional Radiology (G.K.C.W., J.M.A.), Prince of Wales Hospital, The Chinese University of Hong Kong, China; Department of Neurosurgery (K.I.), Washokai Sadamoto Hospital, Matsuyama, Ehime; Department of Neurosurgery (K.M.), Iseikai Hospital, Osaka City, Japan; and Departments of Neurology (M.J.H.W.) and Radiology (M.A.A.v.W.), Leiden University Medical Centre, the Netherlands.
authors.forename: Mervyn D I
authors.initials: MDI
authors.lastname: Vergouwen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000503:physiopathology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D059906:Neuroimaging; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D012422:Rupture, Spontaneous / Q000175:diagnosis; D055815:Young Adult