title: The relationship between anti-C-reactive protein and disease activity in patients with systemic lupus erythematosus.
abstract: Anti-C-reactive protein (CRP) antibody has been introduced as a potential biologic marker in Systemic lupus erythematosus (SLE). The aim of study is to evaluate the level of anti-CRP antibody in patients with SLE.
  
  
  
  This study investigated the relationship between levels of anti-CRP antibodies and disease activity markers, such as complement, anti-double-stranded DNA antibody, and SLE disease activity index in 34 patients with SLE.
  
  
  
  The serum anti-CRP antibody levels of the patients with SLE were significantly higher than those of the healthy controls (11.3 ± 5.6 µg/mL vs. 9.1 ± 2.8 µg/mL). The percentages of the positive anti-CRP antibody were 52.9% in SLE and 27.8% in controls. Disease duration of SLE showed significant correlation with the anti-CRP antibody (r = 0.234, p = 0.026). However no significant relationship was observed between the levels of anti-CRP antibodies and disease activity markers.
  
  
  
  These data show that the anti-CRP antibody levels of the patients with SLE were significantly higher than those of healthy controls. We observed that the presence of the anti-CRP anti-CRP antibody was not associated with disease activity of SLE.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.|Institute for Medical Science, Keimyung University, Daegu, Korea.
authors.forename: Chang-Nam
authors.initials: CN
authors.lastname: Son
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Tae-Han
authors.initials: TH
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Ji-Hye
authors.initials: JH
authors.lastname: Bang
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Jeong
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Jin-Nyeong
authors.initials: JN
authors.lastname: Chae
authors.affiliation: Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Won-Mok
authors.initials: WM
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.|Institute for Medical Science, Keimyung University, Daegu, Korea.
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.|Institute for Medical Science, Keimyung University, Daegu, Korea.
authors.forename: Sang-Hyon
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008181:Lupus Nephritis; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords:  Anti-C-reactive protein antibody; Systemic lupus erythematosus