title: Chromobacterium violaceuminfection in chronic granulomatous disease: a case report and review of the literature.
abstract: Introduction.Chromobacterium violaceumis an opportunistic human pathogen, associated with significant mortality, and has been reported in patients with chronic granulomatous disease (CGD), a genetic condition causing impaired phagocytosis.Case presentation.A 28-year-old man with a history of CGD presented with fever, pharyngitis, cervical lymphadenopathy and internal jugular vein thrombosis, following travel to the rural Solomon Islands.C. violaceumwas recovered from his blood. The patient recovered after treatment with meropenem and trimethoprim/sulfamethoxazole.Conclusion.To the best of our knowledge, this is the first case report of internal jugular vein thrombophlebitis (Lemierre's syndrome) caused byC. violaceumin a patient with CGD. A review of the literature demonstrated that the diagnosis ofC. violaceumpreceded the diagnosis of CGD in the majority of cases. This case emphasizes the importance of this organism in patients with CGD who live in or visit tropical areas.
authors.affiliation: Department of Infectious Diseases, Austin Health , Heidelberg, VIC 3084 , Australia.
authors.forename: Zaal
authors.initials: Z
authors.lastname: Meher-Homji
authors.affiliation: Department of Infectious Diseases, Austin Health , Heidelberg, VIC 3084 , Australia.
authors.forename: Rekha Pai
authors.initials: RP
authors.lastname: Mangalore
authors.affiliation: Department of Infectious Diseases, Austin Health , Heidelberg, VIC 3084 , Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: D R Johnson
authors.affiliation: Department of Infectious Diseases, Austin Health, Heidelberg, VIC 3084, Australia; Department of Microbiology, Austin Health, Heidelberg, VIC 3084, Australia.
authors.forename: Kyra
authors.initials: K
authors.lastname: Y L Chua
keywords: Chromobacterium violaceum; Lemierre's syndrome; meropenem; trimethoprim/sulfamethoxazole