title: The effects of clinical factors on airway outcomes of mandibular distraction osteogenesis in children with Pierre Robin sequence.
abstract: Mandibular distraction osteogenesis (MDO) is an effective treatment for tongue-based airway obstruction in children with severe Pierre Robin sequence. An investigation was performed to determine whether certain clinical factors influence the airway outcomes of MDO. A literature search of several databases was performed to identify studies providing individual patient data. Data extracted from the studies included patient sex, age at distraction, disease type, experience of any previous surgery on the airway, length of distraction, pre- and postoperative blood oxygen saturation nadir, and osteotomy design. Non-parametric tests and multivariate logistic regression analysis were conducted to investigate the potential interaction between these clinical factors and the efficacy of surgery. Five studies met the inclusion criteria, with data available for 73 individual patients. The results of the statistical analysis revealed that few of the factors investigated influenced the surgical efficacy in children with Pierre Robin sequence; the effect of the length of distraction was regarded as uncertain because of the limited amount of individual data available. In conclusion, no influencing factors were found, and according to this analysis, mandibular distraction may be a widely effective procedure. However, more well-designed studies and more individual data are needed to strengthen the results of this meta-analysis.
authors.affiliation: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: X C
authors.initials: XC
authors.lastname: Ren
authors.affiliation: Department of Plastic Surgery, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Gao
authors.affiliation: Orthognathic and TMJ Surgery, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Li
authors.affiliation: Orthognathic and TMJ Surgery, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Orthognathic and TMJ Surgery, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
authors.forename: B
authors.initials: B
authors.lastname: Ye
authors.affiliation: Orthognathic and TMJ Surgery, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address: zss_1977@163.com.
authors.forename: S S
authors.initials: SS
authors.lastname: Zhu
mesh_terms: D000402:Airway Obstruction / Q000209:etiology* / Q000601:surgery*; D002648:Child; D006801:Humans; D008334:Mandible / Q000002:abnormalities / Q000601:surgery*; D019857:Osteogenesis, Distraction / Q000379:methods*; D010855:Pierre Robin Syndrome / Q000150:complications*; D016896:Treatment Outcome
keywords: Pierre Robin sequence; airway obstruction; children; mandibular distraction osteogenesis