title: Development of Novel Vaccines Against Infectious Diseases Based on Chimpanzee Adenoviral Vector.
abstract: Vaccination is considered to be the most effective method of preventing infectious or other diseases. Adenovirus (Ad) is one the most promising vectors in vaccine research and development. It can induce not only potent humoral but also cellular immune responses, and has therefore been widely applied in basic and translational studies. Chimpanzee Ad is a rare serotype circulating in humans. This circumvents the problem of preexisting immunity to human Ad serotypes, enhancing Chimpanzee Ad prospects in vaccine development. Here we describe experimental procedures used to generate a new generation of rabies vaccine based on a chimpanzee Ad vector, which can be extended in the development of novel vaccines against other infectious diseases.
authors.affiliation: Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China.
authors.forename: Yudan
authors.initials: Y
authors.lastname: Chi
authors.affiliation: Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China. dmzhou@sibs.ac.cn.
authors.forename: Dongming
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000256:Adenoviridae / Q000235:genetics* / Q000276:immunology; D000818:Animals; D057809:HEK293 Cells; D006801:Humans; D051379:Mice; D002679:Pan troglodytes / Q000821:virology*; D011819:Rabies Vaccines / Q000235:genetics / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
chemical_list: D011819:Rabies Vaccines; D014614:Vaccines, Synthetic
keywords: Chimpanzee adenovirus; Immune response; Infectious disease; Rabies; Vaccine