title: Bone Response to Porous Poly(methyl methacrylate) Cement Loaded with Hydroxyapatite Particles in a Rabbit Mandibular Model.
abstract: The aim of the current study was to evaluate bone formation and tissue response to porous poly(methyl methacrylate) (PMMA) cement with or without hydroxyapatite (HA) in a rabbit mandibular model. Therefore, 14 New Zealand White rabbits were randomly divided into two groups of seven according to the designed study end points of 4 and 12 weeks. For each rabbit, two decorticated defects (6 mm in height and 10 mm in width for each) were prepared at both sides of the mandible. Subsequently, the defects were filled with, respectively, porous PMMA and porous PMMA-HA cement. After reaching the designated implantation period, the rabbits were euthanized and the mandibles were retrieved for histological analysis. Results showed that both porous PMMA and porous PMMA-HA supported bone repair. Neither of the bone cements caused significant inflammation to nerve or other surrounding tissues. After implantation of 12 weeks, majority of the porosity was filled with newly formed bone for both cements, which supports the concept that a porous structure within PMMA can enhance bone ingrowth. Histomorphometrical evaluation, using histological grading scales, demonstrated that, at both implantation times, the presence of HA in the PMMA enhanced bone formation. Bone was always in direct contact with the HA particles, while intervening fibrous tissue was present at the PMMA-bone interface. On the basis of results, it was concluded that injectable porous PMMA-HA cement might be a good candidate for craniofacial bone repair, which should be further evaluated in a more clinically relevant large animal model.
authors.affiliation: 1 The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University , Wuhan, China .|2 Department of Biomaterials, Radboud University Medical Center , Nijmegen, The Netherlands .
authors.forename: Yue
authors.initials: Y
authors.lastname: Sa
authors.affiliation: 3 National Dental Centre Singapore , Singapore, Singapore .|4 Duke-NUS Medical School , Singapore, Singapore .
authors.forename: Na
authors.initials: N
authors.lastname: Yu
authors.affiliation: 2 Department of Biomaterials, Radboud University Medical Center , Nijmegen, The Netherlands .
authors.forename: Joop G C
authors.initials: JGC
authors.lastname: Wolke
authors.affiliation: 3 National Dental Centre Singapore , Singapore, Singapore .|4 Duke-NUS Medical School , Singapore, Singapore .
authors.forename: Nattharee
authors.initials: N
authors.lastname: Chanchareonsook
authors.affiliation: 3 National Dental Centre Singapore , Singapore, Singapore .|4 Duke-NUS Medical School , Singapore, Singapore .
authors.forename: Bee Tin
authors.initials: BT
authors.lastname: Goh
authors.affiliation: 1 The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University , Wuhan, China .
authors.forename: Yining
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 2 Department of Biomaterials, Radboud University Medical Center , Nijmegen, The Netherlands .
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: 2 Department of Biomaterials, Radboud University Medical Center , Nijmegen, The Netherlands .
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D008297:Male; D008334:Mandible / Q000166:cytology*; D008422:Materials Testing; D023421:Models, Animal; D010012:Osteogenesis / Q000502:physiology*; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D016062:Porosity; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D019904:Polymethyl Methacrylate; D017886:Durapatite
keywords: bone; hydroxyapatite; porous PMMA