title: Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy.
abstract: BACKGROUND
  We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
  
  
  METHODS
  Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period of 12 weeks without exercise. Three times weekly the participants performed aerobic exercise on an ergometer bike or resistance exercise with unilateral training of knee and elbow flexion/extension. Primary outcomes were maximal oxygen consumption velocity (VO2-max) and maximal combined isokinetic muscle strength (cIKS) of knee and elbow flexion/extension.
  
  
  RESULTS
  VO2-max and muscle strength were unchanged during run-in (-4.9% ± 10.3%, P = 0.80 and -3.7% ± 10.1%, P = 0.17, respectively). Aerobic exercise increased VO2-max by 11.0% ± 14.7% (P = 0.02). Resistance exercise resulted in an increase of 13.8% ± 16.0% (P = 0.0004) in cIKS.
  
  
  CONCLUSIONS
  Aerobic exercise training and resistance exercise training improve fitness and strength in CIDP patients. Muscle Nerve 57: 70-76, 2018.
authors.affiliation: Department of Neurology, Aarhus University Hospital, Noerrebrogade 44, DK-8000, Aarhus C, Aarhus, Denmark.
authors.forename: Lars H
authors.initials: LH
authors.lastname: Markvardsen
authors.affiliation: Section for Sport Science, Department of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: Kristian
authors.initials: K
authors.lastname: Overgaard
authors.affiliation: Department of Neurology, Copenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Heje
authors.affiliation: Department of Neurology, Odense University Hospital, Odense, Denmark.
authors.forename: Søren H
authors.initials: SH
authors.lastname: Sindrup
authors.affiliation: Department of Neurology, Copenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Ingelise
authors.initials: I
authors.lastname: Christiansen
authors.affiliation: Department of Neurology, Copenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: John
authors.initials: J
authors.lastname: Vissing
authors.affiliation: Department of Neurology, Aarhus University Hospital, Noerrebrogade 44, DK-8000, Aarhus C, Aarhus, Denmark.
authors.forename: Henning
authors.initials: H
authors.lastname: Andersen
mesh_terms: D015308:Anaerobic Threshold; D001642:Bicycling; D004550:Elbow / Q000503:physiopathology; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007717:Knee / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D010101:Oxygen Consumption / Q000502:physiology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000503:physiopathology / Q000628:therapy*; D011788:Quality of Life; D055070:Resistance Training; D016896:Treatment Outcome
keywords: aerobic training; chronic inflammatory demyelinating polyneuropathy; quality of life; resistance training; subcutaneous immunoglobulin