title: Endoscopic photodynamic therapy using talaporfin sodium for recurrent intranasal carcinomas after radiotherapy in three dogs.
abstract: Radiation is the treatment of choice for canine nasal tumours but, in almost all cases, there is local recurrence associated with poor prognosis. This report describes the effect of endoscopic photodynamic therapy using talaporfin sodium for canine intranasal carcinoma recurring after radiation therapy. Rhinoscopic photodynamic therapy was administered after radiation therapy in three dogs with recurrent intranasal carcinoma. Two to 24 illuminations of a 665-nm diode laser were performed two hours after intravenous bolus injection of 5·0 mg/kg of talaporfin sodium. Photodynamic therapy induced almost complete remission and prolonged survival time in all cases suggesting that it might be a useful treatment for intranasal carcinomas that recur after radiation.
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishigaki
authors.affiliation: Institute of Clinical Medicine and Research, Jikei University School of Medicine, Kashiwa, Chiba, 277-8567, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nariai
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.|Agricultural and Veterinary Division, Meiji Seika Pharma Co., Chuo-ku, Tokyo, 104-8002, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Izumi
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Teshima
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Seki
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Edamura
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-0880, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Asano
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000628:therapy / Q000662:veterinary*; D004285:Dogs; D004724:Endoscopy; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000628:therapy / Q000662:veterinary*; D009669:Nose Neoplasms / Q000628:therapy / Q000662:veterinary*; D010778:Photochemotherapy / Q000662:veterinary; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects / Q000662:veterinary
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; C053434:Talaporfin