title: Dual role for Jumu in the control of hematopoietic progenitors in theDrosophilalymph gland.
abstract: TheDrosophilalymph gland is a hematopoietic organ in which the maintenance of hematopoietic progenitor cell fate relies on intrinsic factors and extensive interaction with cells within a microenvironment. The posterior signaling center (PSC) is required for maintaining the balance between progenitors and their differentiation into mature hemocytes. Moreover, some factors from the progenitors cell-autonomously control blood cell differentiation. Here, we show that Jumeau (Jumu), a member of the forkhead (Fkh) transcription factor family, controls hemocyte differentiation of lymph gland through multiple regulatory mechanisms. Jumu maintains the proper differentiation of prohemocytes by cell-autonomously regulating the expression of Col in medullary zone and by non-cell-autonomously preventing the generation of expanded PSC cells. Jumu can also cell-autonomously control the proliferation of PSC cells through positive regulation of dMyc expression. We also show that a deficiency ofjumuthroughout the lymph gland can induce the differentiation of lamellocytes via activating Toll signaling.
authors.affiliation: Department of Genetics, College of Life Sciences, Northeast Forestry University, Harbin, China.
authors.forename: Yangguang
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Genetics, College of Life Sciences, Northeast Forestry University, Harbin, China.
authors.forename: Li Hua
authors.identifier: 0000-0001-5912-9800
authors.initials: LH
authors.lastname: Jin
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006434:Hemocytes / Q000502:physiology*; D008198:Lymph Nodes / Q000166:cytology*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D014157:Transcription Factors; C412163:jumu protein, Drosophila
keywords: D. melanogaster; Drosophila hematopoiesis; Jumu; MZ; PSC; cell biology; developmental biology; lymph gland; stem cells