title: The role of metabolic reprogramming in T cell fate and function.
abstract: T lymphocytes undergo extensive changes in their metabolic properties during their transition through various differentiation states, from naïve to effector to memory or regulatory roles. The cause and effect relationship between metabolism and differentiation is a field of intense investigation. Many recent studies demonstrate the dependency of T cell functional outcomes on metabolic pathways and the possibility of metabolic intervention to modify these functions. In this review, we describe the basic metabolic features of T cells and new findings on how these correlate with various differentiation fates and functions. We also highlight the latest information regarding the main factors that affect T cell metabolic reprogramming.
authors.affiliation: Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215; Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Patsoukis
authors.affiliation: Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215; Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215.
authors.forename: Kankana
authors.initials: K
authors.lastname: Bardhan
authors.affiliation: Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215; Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215.
authors.forename: Jessica
authors.initials: J
authors.lastname: Weaver
authors.affiliation: Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215; Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215.
authors.forename: Christoph
authors.initials: C
authors.lastname: Herbel
authors.affiliation: Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215; Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Seth
authors.affiliation: Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215; Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215.
authors.forename: Lequn
authors.initials: L
authors.lastname: Li
authors.affiliation: Division of Hematology-Oncology, Harvard Medical School, Boston, MA 02215; Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA 02215.
authors.forename: Vassiliki A
authors.initials: VA
authors.lastname: Boussiotis
keywords: T lymphocytes; differentiation fate and function; metabolism