title: Higher glomerular filtration rate is related to insulin resistance but not to obesity in a predominantly obese non-diabetic cohort.
abstract: Glomerular hyperfiltration has been associated with obesity, insulin resistance, and systolic blood pressure (SBP). However, previous studies are limited by confounders such as pre-existing diabetes or hypertension, or have used indirect measures of adiposity and insulin sensitivity (IS). Therefore, we examined the relationship between estimated glomerular filtration rate (eGFR) and IS measured by the hyperinsulinaemic euglycaemic clamp in a healthy population on no medications. We performed oral glucose tolerance test (OGTT) and measured % body fat (DEXA), BMI, blood pressure and M-value (hyperinsulinaemic euglycaemic clamp) in 104 individuals (44 females and 60 males). The majority of the study population (n = 89, 85.6%) were classified on their BMI as overweight/obese. eGFR was related to age, BMI, M-value (IS), 2-hour glucose levels post OGTT and white blood cell count (WBC) (all p < 0.05); but not to SBP (p = 0.1) or fasting glucose levels (p = 0.2). After adjustment for gender, BMI, SBP and WBC, the inverse association between eGFR and M-value (p = 0.001), and 2-hour glucose post OGTT (p = 0.02) persisted. In conclusion, although eGFR has been associated with BMI and blood pressure in previous studies, in our healthy population, eGFR was more closely related to markers of glucose metabolism (IS and 2-hour glucose post OGTT) than to BMI and blood pressure.
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public health and Preventive Medicine, Monash University, Melbourne, Australia.|Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia.
authors.forename: Negar
authors.initials: N
authors.lastname: Naderpoor
authors.affiliation: School of Population and Global Health, University of Melbourne, Melbourne, Australia.
authors.forename: Jasmine G
authors.initials: JG
authors.lastname: Lyons
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public health and Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: Aya
authors.initials: A
authors.lastname: Mousa
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public health and Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: Sanjeeva
authors.initials: S
authors.lastname: Ranasinha
authors.affiliation: Centre for Chronic Disease Prevention and Management, Victoria University, Melbourne, Australia.
authors.forename: Maximilian P J
authors.initials: MPJ
authors.lastname: de Courten
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public health and Preventive Medicine, Monash University, Melbourne, Australia.|Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia.
authors.forename: Georgia
authors.initials: G
authors.lastname: Soldatos
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public health and Preventive Medicine, Monash University, Melbourne, Australia.|Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia.
authors.forename: Barbora
authors.initials: B
authors.lastname: de Courten
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D050177:Overweight / Q000503:physiopathology*; D011379:Prognosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human