title: Ocular involvement in atypical haemolytic uraemic syndrome.
abstract: METHODS
  The case is presented of a young man with an atypical haemolytic-uraemic syndrome (aHUS), complicated with bilateral serous retinal detachment, cotton wool spots, and a branch artery occlusion. Treatment with plasmapheresis, haemodialysis and systemic eculizumab led to the blood and urine parameters returning to normal, as well as resolution of the retinal anomalies. Genetic analysis show both mutations in complement factor H and C3.
  
  
  CONCLUSIONS
  Haemolytic-uraemic syndrome (HUS) is a thrombotic microangiopathy characterised by microangiopathic haemolytic anaemia, thrombocytopenia, and acute renal failure. Atypical HUS is caused by genetic mutation of complement system. Ocular involvement is an unusual manifestation of this rare syndrome.
authors.affiliation: Servicio de Oftalmología, Hospital San Agustín, Avilés, Asturias, España. Electronic address: ansamlo@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Sampedro López
authors.affiliation: Servicio de Oftalmología, Hospital San Agustín, Avilés, Asturias, España.
authors.forename: B
authors.initials: B
authors.lastname: Domínguez Moro
authors.affiliation: Servicio de Nefrología, Hospital San Agustín, Avilés, Asturias, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Baltar Martin
authors.affiliation: Servicio de Nefrología, Hospital San Agustín, Avilés, Asturias, España.
authors.forename: C
authors.initials: C
authors.lastname: Garcia Monteavaro
authors.affiliation: Servicio de Oftalmología, Hospital San Agustín, Avilés, Asturias, España.
authors.forename: J J
authors.initials: JJ
authors.lastname: Barbón García
mesh_terms: D000328:Adult; D065766:Atypical Hemolytic Uremic Syndrome / Q000150:complications*; D005128:Eye Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D008297:Male
keywords: Atypical haemolytic uraemic syndrome; Desprendimientos serosos retinianos; Microangiopatía trombótica; Purtscher-like retinopathy; Retinopatía tipo Purtscher; Serous retinal detachment; Síndrome hemolítico urémico atípico; Thrombotic microangiopathy