title: The Reliability of a Semi-automated Algorithm for Detection of Cortical Interruptions in Finger Joints on High Resolution CT Compared to MicroCT.
abstract: We developed a semi-automated algorithm for the detection of cortical interruptions in finger joints using high-resolution peripheral quantitative computed tomography (HR-pQCT). Here, we tested its reliability compared to microCT (µCT) as gold standard. Nineteen joints of 10 female anatomic index fingers were imaged by HR-pQCT and µCT (82 and 18 µm isotropic voxel sizes, respectively). The algorithm was applied for detection of cortical interruptions of different minimum diameters (range >0.16 to >0.50 mm). Reliability was tested at the joint level with intra-class correlation coefficient (ICC) for the number of interruptions and interruption surface, and at the level of a single interruption for matching between HR-pQCT and µCT with a fixed interruption diameter (>0.10 mm) on µCT. The positive predictive value (PPV0.10mm) and sensitivity0.10mmwere evaluated. The mean number of interruptions per joint depended on the diameter cut-off and ranged from 3.4 to 53.5 on HR-pQCT and from 1.8 to 45.1 on µCT for interruptions >0.50 to >0.16 mm, respectively. Reliability at the joint level was almost perfect (ICC ≥0.81) for both the number and surface of interruptions >0.16 and >0.33 mm. As expected, the PPV0.10mmincreased with increasing interruption diameter from 84.9 to 100%, for interruptions >0.16 and >0.50 mm, respectively. However, the sensitivity0.10mmdecreased with increasing interruption diameter from 62.4 to 4.7%. This semi-automated algorithm for HR-pQCT in finger joints performed best for the detection of cortical interruptions with a minimum diameter of >0.16 or >0.33 mm, showing almost perfect reliability at the joint level and interruptions matched with those on µCT.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands. michiel.peters@maastrichtuniversity.nl.|Research School CAPHRI, School for Public Health and Primary Care, Maastricht, The Netherlands. michiel.peters@maastrichtuniversity.nl.|NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. michiel.peters@maastrichtuniversity.nl.
authors.forename: M
authors.initials: M
authors.lastname: Peters
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.|Research School CAPHRI, School for Public Health and Primary Care, Maastricht, The Netherlands.|NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Scharmga
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.|Research School CAPHRI, School for Public Health and Primary Care, Maastricht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van Tubergen
authors.affiliation: Department of Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.|Faculty of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Arts
authors.affiliation: Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Loeffen
authors.affiliation: Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Weijers
authors.affiliation: Department of Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.|Faculty of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
authors.forename: B
authors.initials: B
authors.lastname: van Rietbergen
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.|Research School CAPHRI, School for Public Health and Primary Care, Maastricht, The Netherlands.|Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Geusens
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.|NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.|Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.|Department of Internal Medicine, VieCuri Medical Center, Venlo, The Netherlands.
authors.forename: J P
authors.initials: JP
authors.lastname: van den Bergh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging*; D001331:Automation; D005069:Evaluation Studies as Topic; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging*; D006801:Humans; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods; D055114:X-Ray Microtomography / Q000379:methods
keywords: Cortical interruptions; Finger joints; High resolution peripheral quantitative computed tomography; Micro computed tomography; Rheumatoid arthritis