title: Therapy of tacrolimus combined with corticosteroids in idiopathic membranous nephropathy.
abstract: We evaluated the efficacy and safety of tacrolimus (TAC) combined with corticosteroids in treating patients with idiopathic membranous nephropathy (IMN). One hundred seventy-seven biopsy-proven IMN patients were recruited in this retrospective clinical study. Sixty patients received TAC (target blood concentration of 4-8 ng/mL) and 117 patients received daily cyclophosphamide (CYC, 100 mg) combined with prednisone. Remission rates at the end of the first, second and third month in the TAC group were significantly higher than that in the CYC group (1st: 35.0 vs 19.7%, P<0.05; 2nd: 56.7 vs 38.5%, P<0.05; 3rd: 76.7 vs 59.0%, P<0.05). In the first 3 months, daily urinary protein and serum albumin in the TAC group obtained a better improvement than that in the CYC group (P<0.05). At the end of the sixth and the twelfth month, the remission rates, daily urinary protein and serum albumin were all comparable between the two groups (P>0.05). No significant difference of relapse rate between the groups was found (16.3 vs 12.0%, P>0.05). Patients were more likely to develop glucose intolerance in the TAC group. The TAC regimen obtained more benefits in treating IMN patients, especially in the first 3 months, than the CYC regimen.
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: W
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: X
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: X
authors.initials: X
authors.lastname: Min
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: M
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: S
authors.initials: S
authors.lastname: Guan
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: M
authors.initials: M
authors.lastname: Luo
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.|Department of Nephrology, Central Hospital of Jilin City, Jilin, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.|Department of Nephrology, General Hospital of Daqing Oil Field, Daqing, China.
authors.forename: W
authors.initials: W
authors.lastname: Dong
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: L
authors.initials: L
authors.lastname: Miao
authors.affiliation: Department of Nephrology, the Second Hospital of Jilin University, Jilin, China.
authors.forename: P
authors.initials: P
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage*; D011507:Proteinuria; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D016559:Tacrolimus / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D012709:Serum Albumin; D003520:Cyclophosphamide; D003404:Creatinine; D011241:Prednisone; D016559:Tacrolimus