title: Prevalence of obstructive sleep apnea syndrome in a population of patients with transient global amnesia.
abstract: OBJECTIVE
  The etiology of transient global amnesia (TGA) is largely undetermined. The aim of this study was to investigate whether the prevalence of obstructive sleep apnea syndrome (OSAS), a condition associated with subtle changes in brain structures involved in memory processes, increases in subjects who have previously experienced a TGA episode.
  
  
  METHODS
  Twenty-nine patients who had had a TGA episode were included. A case-control model was used, matching cases with controls by sex, age, and body mass index category. Diagnosis of OSAS was based on the results of the Berlin Questionnaire, which was later confirmed by means of an all-night polysomnography recording.
  
  
  RESULTS
  The prevalence of OSAS among TGA patients was significantly higher with respect to that in controls (44.8% vs 13.8%, p = 0.020, χ2test). At logistic regression model, subjects with TGA had an odds ratio of 8.409 (95% confidence interval = 1.674-42.243; p = 0.010) of having OSAS when compared with controls.
  
  
  CONCLUSIONS
  According to our findings, an accurate investigation of sleep disturbances could be considered for a complete assessment of patients with TGA. The subtle cerebral anatomo-functional damage induced by the repeated nocturnal apneic episodes may be a pathophysiologic link between OSAS and TGA.
authors.affiliation: Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Buratti
authors.affiliation: Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Petrelli
authors.affiliation: Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Potente
authors.affiliation: Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Plutino
authors.affiliation: Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Viticchi
authors.affiliation: Internal and Subintensive Medicine, Ospedali Riuniti Ancona, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Falsetti
authors.affiliation: Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Provinciali
authors.affiliation: Neurological Clinic, Marche Polytechnic University, Ancona, Italy. Electronic address: m.silvestrini@univpm.it.
authors.forename: M
authors.initials: M
authors.lastname: Silvestrini
mesh_terms: D000328:Adult; D000368:Aged; D020236:Amnesia, Transient Global / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000453:epidemiology*
keywords: Cerebral dysfunction; Memory; Obstructive sleep apnea syndrome; Transient global amnesia