title: Supplementation with concentrated milk protein in patients undergoing hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  The aim of this study was to analyze the influence of dietary supplementation with whey protein concentrate (WPC) in the incidence of oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT).
  
  
  METHODS
  Patients were supplemented with a daily intake of WPC delivering 50% of the daily protein requirements (DPR) according to the Dietary Reference Intakes and classified later based on the amount of ingested supplement until OM median onset.
  
  
  RESULTS
  We evaluated 73 patients. Forty-three were part of the historical control and 30 were supplemented with WPC. The OM had a mean duration of 5.3 d (SD 4.5), ranging from the day of the infusion of stem cells until the 17th day after infusion and a median of 5 d after infusion. OM duration was influenced by the conditioning protocol (P < 0.01) and WPC (P = 0.01). Patients who consumed the WPC in an amount ≥40% of DPR had a 35% reduction in duration of OM, and the incidence of OM grades 3 and 4 was 11 times smaller. Body mass index, serum albumin, and adverse reactions, such as diarrhea, nausea and vomiting, dysphagia, dry mouth and drooling, showed no statistically significant differences.
  
  
  CONCLUSIONS
  WPC intake ≥40% of DPR helped to reduce the severity and duration of OM. The use of WPC in patients undergoing HSCT was shown to be safe, encouraging new studies in this population to assess its action mechanism.
authors.affiliation: Department of Hematology, Hemotherapy and Bone Marrow Transplantation, Federal University of Juiz de Fora, Minas Gerais, Brazil. Electronic address: anacarolperrone@gmail.com.
authors.forename: Ana Carolina Amaral de São José
authors.initials: AC
authors.lastname: Perrone
authors.affiliation: Department of Hematology, Hemotherapy and Bone Marrow Transplantation, Federal University of Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Thaís Rodrigues
authors.initials: TR
authors.lastname: Barbosa
authors.affiliation: Department of Food Technology, Federal University of Viçosa, Minas Gerais, Brazil.
authors.forename: Fernanda Lopes
authors.initials: FL
authors.lastname: da Silva
authors.affiliation: Department of Food Technology, Federal University of Viçosa, Minas Gerais, Brazil.
authors.forename: Ítalo Tuler
authors.initials: ÍT
authors.lastname: Perrone
authors.affiliation: Department of Food Technology, Federal University of Viçosa, Minas Gerais, Brazil.
authors.forename: Antônio Fernandes
authors.initials: AF
authors.lastname: de Carvalho
authors.affiliation: Department of Chemistry, Federal University of Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Stephani
authors.affiliation: Department of Basic Nursing, Federal University of Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Kelli Borges
authors.initials: KB
authors.lastname: Dos Santos
authors.affiliation: Division of Bone Marrow Transplantation, Monte Sinai Hospital and Department of Clinical Medical, Federal University of Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Ângelo
authors.initials: Â
authors.lastname: Atalla
authors.affiliation: Department of Hematology, Hemotherapy and Bone Marrow Transplantation, Federal University of Juiz de Fora, Minas Gerais, Brazil; Department of Clinical Medical, Federal University of Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Abrahão Elias
authors.initials: AE
authors.lastname: Hallack Neto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D019587:Dietary Supplements; D005069:Evaluation Studies as Topic; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D064167:Recommended Dietary Allowances; D013280:Stomatitis / Q000517:prevention & control*; D000067816:Whey Proteins / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000067816:Whey Proteins
keywords: Bone marrow transplantation; Conditioning protocol; Dairy product; Mucositis; Recommended daily protein intake