title: Characterization of the thrombin generation profile in systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is a multisystemic inflammatory autoimmune disorder. Thrombotic events occur at a higher incidence among SLE patients. The investigation of thrombin generation (TG) with calibrated automated thrombogram (CAT) test as a global hemostasis assay is applicable for the overall functional assessment of the hemostasis. The aim of this study was to characterize the hemostatic alterations observed in SLE by CAT assay. In this study, CAT parameters and basic coagulation parameters of SLE patients (n = 22) and healthy control subjects (n = 34) were compared. CAT area under the curve (i.e., endogenous thrombin potential) was lower than normal in SLE (807 vs. 1,159 nM*min, respectively), whereas other CAT parameters (peak, lag time, time to peak, and velocity index) and the basic coagulation tests were within the normal range. The presence of anti-phospholipid antibodies and the applied therapy was not associated with hemostasis parameters in SLE. We concluded that the reported high risk of thrombosis is not related to TG potential.
authors.affiliation: 1 Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University , Budapest, Hungary.|2 Diagon Ltd. , Budapest, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Kern
authors.affiliation: 1 Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University , Budapest, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Barabás
authors.affiliation: 3 Department of Rheumatology, Faculty of Medicine, Albert Szent-Györgyi Health Center, University of Szeged , Szeged, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Balog
authors.affiliation: 3 Department of Rheumatology, Faculty of Medicine, Albert Szent-Györgyi Health Center, University of Szeged , Szeged, Hungary.
authors.forename: Sz
authors.initials: S
authors.lastname: Burcsár
authors.affiliation: 2 Diagon Ltd. , Budapest, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Kiszelák
authors.affiliation: 1 Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University , Budapest, Hungary.
authors.forename: B
authors.initials: B
authors.lastname: Vásárhelyi
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D016022:Case-Control Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D013917:Thrombin / Q000378:metabolism*; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*
chemical_list: D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D013917:Thrombin
keywords: anti-phospholipid antibodies; endogenous thrombin potential; systemic lupus erythematosus; thrombin generation; thrombosis