title: Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care.
abstract: For decades, it has been speculated that specific loci on eukaryotic chromosomes are inherently susceptible to breakage. The advent of high-throughput genomic technologies has now paved the way to their identification. A wealth of data suggests that transcriptionally active loci are particularly fragile and that a specific DNA damage response is activated and dedicated to their repair. Here, we review current understanding of the crosstalk between transcription and double-strand break repair, from the reasons underlying the intrinsic fragility of genes to the mechanisms that restore the integrity of damaged transcription units.
authors.affiliation: LBCMCP, Centre de Biologie Intégrative (CBI), CNRS, Université de Toulouse, UT3, 118 Route de Narbonne, 31062 Toulouse, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Marnef
authors.affiliation: LBCMCP, Centre de Biologie Intégrative (CBI), CNRS, Université de Toulouse, UT3, 118 Route de Narbonne, 31062 Toulouse, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Cohen
authors.affiliation: LBCMCP, Centre de Biologie Intégrative (CBI), CNRS, Université de Toulouse, UT3, 118 Route de Narbonne, 31062 Toulouse, France. Electronic address: gaelle.legube@univ-tlse3.fr.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Legube
mesh_terms: D053903:DNA Breaks, Double-Stranded; D059767:Recombinational DNA Repair; D014158:Transcription, Genetic
keywords: DNA double-strand break repair; chromatin; transcription