title: Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings.
abstract: The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of transforming growth factor-β2 (TGF-β2) in chondroblasts during the two weeks after surgery. In the delayed posttraumatic period, the distribution of TGF-β2 inversely related to its maximal activity. The data revealed the up-regulating effect of bioresorbable coatings on expression of VEGF and TGF-β2 and their implication in the control over various stages of reparative osteogenesis.
authors.affiliation: Department of Histology, Cytology, and Embryology, Pacific State Medical University, Vladivostok, Russia. sgkalinichenko@gmail.com.|Laboratory of Biomedical Composition Coatings, Institute of Chemistry, Far-East Division of Russian Academy of Sciences, Vladivostok, Russia. sgkalinichenko@gmail.com.
authors.forename: S G
authors.initials: SG
authors.lastname: Kalinichenko
authors.affiliation: Department of Histology, Cytology, and Embryology, Pacific State Medical University, Vladivostok, Russia.|Laboratory of Biomedical Composition Coatings, Institute of Chemistry, Far-East Division of Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Matveeva
authors.affiliation: Department of Histology, Cytology, and Embryology, Pacific State Medical University, Vladivostok, Russia.
authors.forename: R E
authors.initials: RE
authors.lastname: Kostiv
authors.affiliation: Laboratory of Biomedical Composition Coatings, Institute of Chemistry, Far-East Division of Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Puz'
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D001863:Bone Screws; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002130:Calcium Phosphates / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D017102:Fracture Healing; D008297:Male; D051381:Rats; D014025:Titanium; D053781:Transforming Growth Factor beta2 / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology*
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C509043:Tgfb2 protein, rat; D053781:Transforming Growth Factor beta2; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium
keywords: bioactive nanoscale materials; bone tissue remodeling; morphogenetic factors