title: In silicofunctional elucidation of uncharacterized proteins ofChlamydia abortusstrain LLG.
abstract: OBJECTIVE
  This study reports structural modeling, molecular dynamics profiling of hypothetical proteins inChlamydia abortusgenome database.
  
  
  METHODS
  The hypothetical protein sequences were extracted fromC. abortusLLG Genome Database for functional elucidation usingin silicomethods.
  
  
  RESULTS
  Fifty-one proteins with their roles in defense, binding and transporting other biomolecules were unraveled. Forty-five proteins were found to be nonhomologous to proteins present in hosts infected byC. abortus. Of these, 31 proteins were related to virulence. The structural modeling of two proteins, first, WP_006344020.1 (phosphorylase) and second, WP_006344325.1 (chlamydial protease/proteasome-like activity factor) were accomplished. The conserved active sites necessary for the catalytic function were analyzed.
  
  
  CONCLUSIONS
  The finally concluded proteins are envisioned as possible targets for developing drugs to curtail chlamydial infections, however, and should be validated by molecular biological methods.
authors.affiliation: Centre for Computational Biology & Bioinformatics, Central University of Himachal Pradesh, Shahpur 176206, India; Centre for Computational Biology & Bioinformatics, Central University of Himachal Pradesh, Shahpur 176206, India.
authors.forename: Gagandeep
authors.initials: G
authors.lastname: Singh
authors.affiliation: Centre for Computational Biology & Bioinformatics, Central University of Himachal Pradesh, Shahpur 176206, India; Centre for Computational Biology & Bioinformatics, Central University of Himachal Pradesh, Shahpur 176206, India.
authors.forename: Dixit
authors.initials: D
authors.lastname: Sharma
authors.affiliation: Centre for Computational Biology & Bioinformatics, Central University of Himachal Pradesh, Shahpur 176206, India; Centre for Computational Biology & Bioinformatics, Central University of Himachal Pradesh, Shahpur 176206, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Singh
authors.affiliation: Department of Botany, Punjabi University, Patiala 147002, India; Department of Botany, Punjabi University, Patiala 147002, India.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Rani
authors.affiliation: ReGenera Research Group of Aging-Intervention & Montenapoleone Medical Centre, Milano, Italy; ReGenera Research Group of Aging-Intervention & Montenapoleone Medical Centre, Milano, Italy.
authors.forename: Francessco
authors.initials: F
authors.lastname: Marotta
authors.affiliation: Department of Microbiology & Immunology, National Institute of Nutrition, Hyderabad 500007, India; Department of Microbiology & Immunology, National Institute of Nutrition, Hyderabad 500007, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
authors.affiliation: ICAR-Indian Veterinary Research Institute, Regional Station, Palampur 176061, India; ICAR-Indian Veterinary Research Institute, Regional Station, Palampur 176061, India.
authors.forename: Gorakh
authors.initials: G
authors.lastname: Mal
authors.affiliation: ICAR-Indian Veterinary Research Institute, Regional Station, Palampur 176061, India; ICAR-Indian Veterinary Research Institute, Regional Station, Palampur 176061, India.
authors.forename: Birbal
authors.initials: B
authors.lastname: Singh
keywords: Chlamydia abortus; functional annotation; hypothetical proteins