title: Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis.
abstract: Osteoporosis and periodontal disease are linked by an altered receptor activator of nuclear factor κB ligand and osteoprotegerin ratio (RANKL/OPG), and medical treatment with bisphosphonate (BP) may help control these molecules. The effect of BP on clinical findings and gingival crevicular fluid (GCF) values of RANKL and OPG using enzyme-linked immunosorbent assays was evaluated in postmenopausal women; 13 patients with both chronic periodontitis and osteoporosis (group A), 12 systemically healthy patients with chronic periodontitis (group B), 12 periodontally healthy patients with osteoporosis (group C), and 10 systemically and periodontally healthy individuals (group D). Recordings were repeated at the end of months 1, 6, and 12 in groups A, B, and C. At the baseline, groups A and B exhibited the lowest OPG values (P < 0.05). After periodontal treatment, OPG values were markedly increased at the end of 6th month in group A and 12th month in group B (P < 0.008). There was no significant difference in GCF RANKL values among groups (P > 0.05) or during the observation period (P > 0.008). The use of BP may be effective in preventing periodontal breakdown by controlling the levels of these markers in osteoporosis as an adjunct to periodontal treatment.
authors.affiliation: Department of Periodontology, School of Dentistry, Ondokuz Mayis University.
authors.forename: Feyza O
authors.initials: FO
authors.lastname: Özden
authors.forename: Elif E
authors.initials: EE
authors.lastname: Sakallioğlu
authors.forename: Esra
authors.initials: E
authors.lastname: Demir
authors.forename: Birşen
authors.initials: B
authors.lastname: Bilgici
authors.forename: Özgür K
authors.initials: ÖK
authors.lastname: Tunçel
authors.forename: Feyzi
authors.initials: F
authors.lastname: Gökosmanoğlu
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Atmaca
mesh_terms: D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000188:drug therapy*; D004164:Diphosphonates / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000378:metabolism*; D053244:Osteoprotegerin / Q000378:metabolism*; D053245:RANK Ligand / Q000378:metabolism*
chemical_list: D004164:Diphosphonates; D053244:Osteoprotegerin; D053245:RANK Ligand; C505688:TNFSF11 protein, human