title: A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma.
abstract: Early detection and therapy of esophageal cancer is very important for improving the prognosis and survival rate of the patient. A theranostic agent that combines multimodal imaging with cancer therapy may be used for augmenting the visualization and treatment of the cancer. Herein, we report the synthesis of a hollow tantalum oxide (TaOx) nanoparticle that was successfully engineered by encapsulation of polypyrrole (PPy) and doxorubicin (DOX) in the core and conjugation with a near infrared fluorescence dye (NIRDye800) on the shell of the hollow TaOxnanoparticles. The as-prepared core/shell nanoparticles showed multimodal imaging features including computed tomography (CT) (for the preliminary location of the tumor), photoacoustic (for the anatomical localization of the tumor), and fluorescence imaging (for real-time monitoring of the tumor margin) and pH- and thermal-sensitive drug release. Because the early esophageal carcinoma is a type of superficial cancer, a subcutaneous model in the thigh was used for the in vivo study. The core/shell nanoparticles shows high imaging contrast between the tumor and the adjacent tissues and controllable photothermal therapy (PTT) and chemotherapy. Our results indicated that the obtained core/shell nanoparticles had significant potential in the triple-modality imaging guided precisely chemo-thermal synergetic therapy of esophageal cancer. In addition, after aerosol administration, our nanoparticles also exhibited comparable therapeutic efficacy with the intravenous administration, which is more suitable for clinical therapy of esophageal carcinoma.
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Beijing Key Laboratory Molecular Imaging, Beijing 100190, China.
authors.forename: Yushen
authors.initials: Y
authors.lastname: Jin
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Beijing Key Laboratory Molecular Imaging, Beijing 100190, China.
authors.forename: Xibo
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Control Science and Engineering, Shandong University, Jinan 250061, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Meng
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Beijing Key Laboratory Molecular Imaging, Beijing 100190, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Beijing Key Laboratory Molecular Imaging, Beijing 100190, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Urology Surgery, The Fourth Hospital of Harbin Medical University, Harbin, 150001, China. Electronic address: xuwanhai@163.com.
authors.forename: Wanhai
authors.initials: W
authors.lastname: Xu
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; Beijing Key Laboratory Molecular Imaging, Beijing 100190, China; The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Science, Beijing 100190, China. Electronic address: jie.tian@ia.ac.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000008:administration & dosage* / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D065546:Drug Liberation; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D005456:Fluorescent Dyes / Q000008:administration & dosage* / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging / Q000379:methods*; D053758:Nanoparticles; D061848:Optical Imaging; D010087:Oxides / Q000008:administration & dosage* / Q000737:chemistry; D061088:Photoacoustic Techniques; D010789:Phototherapy / Q000379:methods*; D011108:Polymers / Q000737:chemistry; D011237:Predictive Value of Tests; D011758:Pyrroles / Q000737:chemistry; D012995:Solubility; D013635:Tantalum / Q000008:administration & dosage* / Q000737:chemistry; D013696:Temperature; D000068936:Theranostic Nanomedicine; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D023041:Xenograft Model Antitumor Assays
chemical_list: D000903:Antibiotics, Antineoplastic; D003287:Contrast Media; D004337:Drug Carriers; D005456:Fluorescent Dyes; D010087:Oxides; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D013635:Tantalum; D004317:Doxorubicin; C078151:tantalum oxide
keywords: Chemo-thermal synergetic therapy; Esophageal carcinoma; Tantalum oxide; Triggered drug release; Triple-modality imaging