title: New cell engineering approaches for cartilage regenerative medicine.
abstract: Articular cartilage injuries have an inadequate aptitude to reproduce the original structure and functions of this highly specialized tissue. As most of the currently available options also do not lead to the restoration of the original hyaline cartilage, novel treatments are critically needed to address this global problems in the clinics. Gene therapy combined with tissue engineering approaches offers effective tools capable of enhancing cartilage repair experimentally, especially those based on the controlled delivery of the highly effective, clinically adapted recombinant adeno-associated viral (rAAV) vectors. This work presents an overview of the most recent evidence showing the benefits of using rAAV vectors and biocompatible materials for the elaboration of adapted treatments against cartilage injuries.
authors.affiliation: Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr, Bldg 37, D-66421 Homburg/Saar, Germany.
authors.forename: Magali
authors.initials: M
authors.lastname: Cucchiarini
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D060846:Cell Engineering / Q000379:methods*; D000229:Dependovirus / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*
keywords: articular cartilage; rAAV vectors; repair; tissue engineering