title: Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile?
abstract: Inflammasomes are multiprotein complexes that form in the cytoplasm in response to cellular damage and cytosolic pathogen-associated molecules during infection. These complexes play important roles in initiating innate and adaptive immune responses to infectious disease. In addition, inflammasomes are now recognized as important mediators of sterile inflammation in various autoimmune and autoinflammatory diseases. Interestingly, microbiota and infection play critical roles in the development of 'sterile inflammation'. Herein, we highlight recent advances in our understanding of the role for inflammasomes in nucleic acid-, nucleosome-, and histone-driven sterile inflammation and discuss knowledge gaps and areas of potential future research.
authors.affiliation: Department of Biology, Missouri State University, Springfield, MO, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Lupfer
authors.affiliation: Department of Biology, Missouri State University, Springfield, MO, USA.
authors.forename: Angeline
authors.initials: A
authors.lastname: Rodriguez
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: Thirumala-Devi
authors.initials: TD
authors.lastname: Kanneganti
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D004249:DNA Damage; D004269:DNA, Bacterial / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D058847:Inflammasomes / Q000276:immunology / Q000378:metabolism*; D064307:Microbiota; D018448:Models, Immunological; D009707:Nucleosomes / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D012329:RNA, Bacterial / Q000378:metabolism
chemical_list: D004269:DNA, Bacterial; D004272:DNA, Mitochondrial; D006657:Histones; D058847:Inflammasomes; D009707:Nucleosomes; D012329:RNA, Bacterial
keywords: AIM2; Caspase-1; IL-18; IL-1β; NLRP3; autoimmunity; autoinflammation; immunopathology; inflammasome; inflammation