title: Roles of AEG-1 in CNS neurons and astrocytes during noncancerous processes.
abstract: Since its initial identification, Astrocyte Elevated Gene-1 (AEG-1) has been recognized as a "star" gene detected in most of the analyzed cancers; AEG-1 can interact with signaling transduction molecules, such as PI3K/Akt and MAPK, to affect the function and viability of cells. Furthermore, its multiple other functions are also gradually being recognized. AEG-1 participates in several biological processes, including embryonic development, glutamate excitotoxicity, inflammation, and endoplasmic reticulum stress. Most of the noncancerous roles of the AEG-1 were identified in studies of the neurological disorders of the CNS. As an oncogene that promotes aberrant cellular processes within the CNS, AEG-1 may also represent an important therapeutic target for the treatment of neurological disease. However, the exact role of the AEG-1 in CNS under normal conditions is still unknown. This review will focus on the literature describing the role of this molecule in CNS neurons and astrocytes during noncancerous processes. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, People's Republic of China.
authors.forename: Xiang
authors.identifier: 0000-0002-0448-2196
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Honglin
authors.initials: H
authors.lastname: Feng
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins; D009474:Neurons / Q000378:metabolism*; D016601:RNA-Binding Proteins
chemical_list: D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
keywords: AEG-1; astrocyte; neuron; noncancerous pathologies