title: Diabetic ulcer regeneration: stem cells, biomaterials, growth factors.
abstract: The impairment of ulcer wound healing in diabetic patients is a vital clinical problem affecting millions of patients. Several clinical and basic science studies have demonstrated that stem cell therapy, to be effective in healing diabetic ulcer. Furthermore, these ulcer wounds may be healed from molecular maneuvering of growth factors to improve microcirculation within the ulcer wound. In addition, ulcer wound dressings may be employed as medicated systems, through the delivery of drugs, growth factors, peptides and stem cells. These dressing materials can include natural, modified and synthetic polymers, as well as their mixtures or combinations. This review paper will give a summary of some of the recent advances on the application of stem cells, biomaterials and growth factors in the treatment of diabetic ulcer wound.
authors.affiliation: a Department of Surgery , Lorestan University of Medical Sciences , Khorramabad , Iran.
authors.forename: Farshad
authors.initials: F
authors.lastname: Zarei
authors.affiliation: b Department of Medical Biotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical sciences , Tehran , Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Negahdari
authors.affiliation: b Department of Medical Biotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical sciences , Tehran , Iran.|c Department of Medical Biotechnology , School of Medicine, Lorestan University of Medical sciences , Khoramabad , Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Eatemadi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D048909:Diabetes Complications / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D033581:Stem Cell Transplantation; D014456:Ulcer / Q000473:pathology / Q000503:physiopathology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins
keywords: Diabetic ulcer; biomaterials; growth factors; stem cells; wound dressings