title: Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states.
abstract: Animals continuously alternate between sleep and wake states throughout their life. The daily organization of sleep and wakefulness is orchestrated by circadian, homeostatic, and motivational processes. Over the last decades, much progress has been made toward determining the neuronal populations involved in sleep/wake regulation. Here, we will discuss how the application of advancedin vivotools for cell type-specific manipulations now permits the functional interrogation of different features of sleep/wake state regulation: initiation, maintenance, and structural organization. We will specifically focus on recent studies examining the roles of wake-promoting neuronal populations.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Ada
authors.initials: A
authors.lastname: Eban-Rothschild
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
authors.forename: Luis
authors.initials: L
authors.lastname: de Lecea
keywords: NREM; REM; neuronal circuits; sleep regulation; sleep transitions; vigilance states