title: The pharmacological research of Tek-1 relevance to anti-neuroinflammation, a candidate compound based on Telmisartan.
abstract: In this paper, BV-2 mouse small glial cell inflammation model induced by LPS is established. The experiment used 0.1-10 μM of telmisartan and Tek-1 to incubate with small glial cell and used telmisartan and Tek-1 to incubate with PPAR gamma special heterosexual antagonistic anti-agent GW9662. The article used ELISA method to dectect TNF-a effect on small glial cell for telmisartan and Tek-1. The article used real-time quantitative PCR method to dectect mRNA level expression effect of CD11b, CD16 and iNOS on small glial cell for telmisartan and Tek-1 and used Western Blot method to dectect MAPKs signal pathway and NF-κb signal turned guide pathway effect on small glial cell for telmisartan and Tek-1. Results show that Tek-1 had high affinity with AT1 receptor and inhibited intracellular calcium ion activation which can be for the AT1 receptor antagonists. Meanwhile, Tek-1 can partially activate PPAR gamma compared with full agonists of rosiglitazone.
authors.affiliation: Department of Neurology, Xian Jiao Tong University, Postal code 710061, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Vasculocardiology, Xian Jiao Tong University, Postal code 710061, China.
authors.forename: Changcong
authors.initials: C
authors.lastname: Cui
keywords: Broad nasal tip; Cartilage rhinoplasty; Dome-splitting; Goldman technique