title: Chelation versus Non-Chelation Control in the Stereoselective Alkenyl sp2C-H Bond Functionalization Reaction.
abstract: A hydroxy group chelation-assisted stereospecific oxidative cross-coupling reaction between alkenes was developed under mild reaction conditions. In the presence of palladium catalyst, the alkenes tethered with hydroxy functionality can couple efficiently with electron-deficient alkenes to form the corresponding multi-substituted olefin products. The hydroxy group on the substrate could play dual roles in reaction, acting as the directing group for alkenyl C-H bond activation and controlling the stereoselectivity of the products.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, China.
authors.forename: Qiu-Ju
authors.initials: QJ
authors.lastname: Liang
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, China.
authors.forename: Fei-Fan
authors.initials: FF
authors.lastname: Meng
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, China.
authors.forename: Yun-He
authors.initials: YH
authors.lastname: Xu
authors.affiliation: Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, China.|Institute of Advanced Synthesis, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, 30 South Puzhu Road, Nanjing, Jiangsu, 210009, China.|Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637616, Singapore.
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh
keywords: C−H activation; alkenylation; cross-coupling; palladium