title: Targeting active cancer cells with smart bullets.
abstract: Paul Ehrlich's 'magic bullet' concept has stimulated research for therapeutic agents with the capability to go straight to their intended targets. The 'magic bullet' concept is still considered the ultimate approach to maximize the therapeutic effects of a given therapeutic agent without affecting nontargeted tissues. But so far, there has never been a therapeutic agent or a delivery system that goes straight to the target in the body, and no approach has provided anything better than just a few percents of the total administered dose reaching the intended target sites. But engineering principles can transform systematically circulating vectors that so far were based primarily on physical characteristics and biochemical principles alone, as smart therapeutic agents with the required propulsion-navigation-homing capabilities to enable them to go straight to their intended targets.
authors.affiliation: NanoRobotics Laboratory, Department of Computer & Software Engineering, Institute of Biomedical Engineering, Polytechnique Montréal, Montréal, QC, Canada.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Martel
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
keywords: cancer translational research; clinical MRI scanner; high therapeutic index; magnetic fields; magnetotactic bacteria; nonsystemic therapeutic delivery; robotic functionalities; smart delivery agents; targeting active cancer cells; tumor hypoxic zones; vascular navigation