title: Effect of Underlying Renal Disease on Nutritional and Metabolic Profile of Older Adults with Reduced Renal Function.
abstract: Chronic kidney disease is a common condition in the general population, particularly among older adults. Renal impairment is in turn associated with metabolic and nutritional derangements and with increased risk of cardiovascular disease.
  
  
  
  To compare the metabolic, nutritional, and cardiovascular impact of reduced kidney function between patients with and without known renal disease.
  
  
  
  We enrolled consecutive outpatients (age ≥65 years) with reduced renal function who were divided into two groups: Group A with history of renal disease and Group B with unknown renal disease. Metabolic and nutritional parameters, including involuntary body weight loss (BWL) in the previous 6 months, mineral metabolism, inflammatory indices, and left ventricular mass index (LVMI), were evaluated.
  
  
  
  A total of 76 patients were enrolled. Group A (n= 39, M: 24, F: 15) showed greater BWL with a significant reduction of 25-hydroxyvitamin D, transferrin, cholinesterase, albumin, and greater [corrected] LVMI with respect to Group B (n = 37, M: 23, F: 14) (p< 0.01). In addition, Group A [corrected] showed significantly increased intact parathyroid hormone, total cholesterol, low-density lipoprotein, triglycerides, and C-reactive protein when compared to Group B [corrected] (p< 0.05).
  
  
  
  The positive history of renal disease may negatively impact on several metabolic and nutritional parameters related to increased cardiovascular risk among older adults.
authors.affiliation: Department of Clinical Medicine, Sapienza University of Rome , Rome , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Lai
authors.affiliation: Department of Clinical Medicine, Sapienza University of Rome , Rome , Italy.
authors.forename: Maria Ida
authors.initials: MI
authors.lastname: Amabile
authors.affiliation: Department of Clinical and Molecular Medicine, Sapienza University of Rome, UOC Nephrology, Sant' Andrea Hospital , Rome , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Altieri
authors.affiliation: Nephrology and Dialysis Unit, Hospital ICOT Latina, Sapienza University of Rome , Rome , Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Mastroluca
authors.affiliation: Department of Dynamic and Clinic Psychology, Sapienza University of Rome , Rome , Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Lai
authors.affiliation: Department of Anesthesiology and Intensive Care, Catholic University of Sacred Heart Rome , Rome , Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Aceto
authors.affiliation: Software House INTECS S.p.A. , Rome , Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Crudo
authors.affiliation: Department of Obstetrical-Gynecological Sciences and Urologic Sciences, Sapienza University of Rome , Rome , Italy.
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: D'Angelo
authors.affiliation: Department of Clinical Medicine, Sapienza University of Rome , Rome , Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Muscaritoli
authors.affiliation: Department of Clinical Medicine, Sapienza University of Rome , Rome , Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Molfino
keywords: cardiovascular disease; chronic kidney disease; inflammation; older adults; weight loss