title: Combination of aerobic exercise and an arginine, alanine, and phenylalanine mixture increases fat mobilization and ketone body synthesis.
abstract: During exercise, blood levels of several hormones increase acutely. We hypothesized that consumption of a specific combination of amino acids (arginine, alanine, and phenylalanine; A-mix) may be involved in secretion of glucagon, and when combined with exercise may promote fat catabolism. Ten healthy male volunteers were randomized in a crossover study to ingest either A-mix (3 g/dose) or placebo (3 g of dextrin/dose). Thirty minutes after ingesting, each condition subsequently performed workload trials on a cycle ergometer at 50% of maximal oxygen consumption for 1 h. After oral intake of A-mix, the concentrations of plasma ketone bodies and adrenalin during and post-exercise were significantly increased. The area under the curve for glycerol and glucagon was significantly increased in the post-exercise by A-mix administration. These results suggest that pre-exercise ingestion of A-mix causes a shift of energy source from carbohydrate to fat combustion by increasing secretion of adrenalin and glucagon.
authors.affiliation: a Food Science Research Labs, R&D Division , Meiji Co., Ltd. , Odawara , Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ueda
authors.affiliation: a Food Science Research Labs, R&D Division , Meiji Co., Ltd. , Odawara , Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Sanbongi
authors.affiliation: a Food Science Research Labs, R&D Division , Meiji Co., Ltd. , Odawara , Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Takai
authors.affiliation: a Food Science Research Labs, R&D Division , Meiji Co., Ltd. , Odawara , Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Ikegami
authors.affiliation: b College of Sport and Health Science , Ritsumeikan University , Kusatsu-shi , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000284:Administration, Oral; D000409:Alanine / Q000008:administration & dosage*; D001120:Arginine / Q000008:administration & dosage*; D056352:Athletes; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007657:Ketone Bodies / Q000819:agonists / Q000096:biosynthesis*; D008297:Male; D008660:Metabolism / Q000187:drug effects; D010101:Oxygen Consumption / Q000502:physiology; D010649:Phenylalanine / Q000008:administration & dosage*; D012916:Soccer; D055815:Young Adult
chemical_list: D007657:Ketone Bodies; D010649:Phenylalanine; D005934:Glucagon; D001120:Arginine; D000409:Alanine; D004837:Epinephrine
keywords: amino acid supplementation; hormones; metabolism; pre-exercise nutrition