title: Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary.
abstract: Though bioaccumulation of pharmaceuticals has received attention in inland waters, studies of pharmaceutical bioaccumulation in estuarine and marine systems are limited. Further, an understanding of pharmaceutical bioaccumulation across size classes of organisms displaying ontogenetic feeding shifts is lacking. We selected the striped mullet, Mugil cephalus, a euryhaline and eurythermal species that experiences dietary shifts with age, to identify whether a model base, diphenhydramine, accumulated in a tidally influenced urban bayou. We further determined whether diphenhydramine accumulation differed among size classes of striped mullet over a two year study period. Stable isotope analysis identified that ontogenetic feeding shifts of M. cephalus occurred from juveniles to adults. However, bioaccumulation of diphenhydramine did not significantly increase across age classes of M. cephalus but corresponded to surface water levels of the pharmaceutical, which suggests inhalational uptake to diphenhydramine was more important for bioaccumulation than dietary exposure in this urban estuary.
authors.affiliation: Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX, USA.
authors.forename: Samuel P
authors.initials: SP
authors.lastname: Haddad
authors.affiliation: Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX, USA; The Institute of Ecological, Earth, and Environmental Science, Baylor University, Waco, TX, USA.
authors.forename: Bowen
authors.initials: B
authors.lastname: Du
authors.affiliation: Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX, USA.
authors.forename: W Casan
authors.initials: WC
authors.lastname: Scott
authors.affiliation: Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX, USA.
authors.forename: Gavin N
authors.initials: GN
authors.lastname: Saari
authors.affiliation: Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Breed
authors.affiliation: Texas Commission on Environmental Quality, Houston, TX, USA; Texas Parks and Wildlife Department, Austin, TX, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Kelly
authors.affiliation: Texas Commission on Environmental Quality, Houston, TX, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Broach
authors.affiliation: Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX, USA; The Institute of Ecological, Earth, and Environmental Science, Baylor University, Waco, TX, USA; Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA.
authors.forename: C Kevin
authors.initials: CK
authors.lastname: Chambliss
authors.affiliation: Department of Environmental Science, Center for Reservoir and Aquatic Systems Research, Baylor University, Waco, TX, USA; The Institute of Ecological, Earth, and Environmental Science, Baylor University, Waco, TX, USA. Electronic address: bryan_brooks@baylor.edu.
authors.forename: Bryan W
authors.initials: BW
authors.lastname: Brooks
mesh_terms: D000818:Animals; D004032:Diet; D004155:Diphenhydramine / Q000378:metabolism*; D004784:Environmental Monitoring; D063366:Estuaries; D023701:Smegmamorpha / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000378:metabolism*
chemical_list: D014874:Water Pollutants, Chemical; D004155:Diphenhydramine
keywords: Bioaccumulation factor; Bioconcentration; Effluent; Estuaries and coasts; Striped mullet; Urban ecosystems; Urbanization