title: Severe Asthma in Children.
abstract: OBJECTIVE
  The aim of this study is to characterize, diagnose, evaluate, and treat severe childhood asthma.
  
  
  RESULTS
  Understanding the occurrence of the physiologic and clinical presentations of childhood severe asthma, the treatment and response may be predicted by biomarkers, but the patient's response is highly variable. The onset of severe asthma occurs early and is primarily predicted by severity of viral infection and coexistence of the atopic state.
authors.affiliation: Capital Allergy and Respiratory Disease Center, 5609 J Street, Suite C, Sacramento, CA, 95819, USA. bchipps@capitalallergy.com.
authors.forename: Bradley E
authors.initials: BE
authors.lastname: Chipps
authors.affiliation: Capital Allergy and Respiratory Disease Center, 5609 J Street, Suite C, Sacramento, CA, 95819, USA.
authors.forename: Neil G
authors.initials: NG
authors.lastname: Parikh
authors.affiliation: Capital Allergy and Respiratory Disease Center, 5609 J Street, Suite C, Sacramento, CA, 95819, USA.
authors.forename: Sheena K
authors.initials: SK
authors.lastname: Maharaj
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D001688:Biological Products / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D002908:Chronic Disease; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications; D012720:Severity of Illness Index; D014777:Virus Diseases / Q000150:complications
chemical_list: D000305:Adrenal Cortex Hormones; D001688:Biological Products; D015415:Biomarkers; D018680:Cholinergic Antagonists
keywords: Biologic therapy; Biomarkers; Childhood asthma; Pharmacologic therapy; Severe asthma