title: [Assessment of changes in the lesions sizes and the incidence of complete epithelialization during the treatment of diabetic foot syndrome over a period of 4 weeks (multicenter study)].
abstract: OBJECTIVE
  To assess the effectiveness of the collagen biomaterial in treatment process in patients with DFS.
  
  
  METHODS
  71 patients 30-80 y.o. with diabetic foot syndrome of varying severity were included in prospective multicenter study. Patients were randomized into two homogeneous groups: control group (n=35) - standard therapy, other 36 patients (main group) were additionally treated with medical device (MD) Collost in accordance with the instructions for use.
  
  
  RESULTS
  Biomaterial Collost using in complex treatment of diabetic foot syndrome resulted in more rapid and effective healing of the ulcer. The treatment success increased from 43% to 72%. Complete epithelialization was achieved by 2.6 times more rapidly in conjunction with reduction the incidence of unsuccessful treatment results by 4.1 times.
authors.affiliation: N.I. Pirogov Russian National Research University.
authors.forename: V A
authors.initials: VA
authors.lastname: Stupin
authors.affiliation: I.M. Sechenov First Moscow State Medical University.
authors.forename: E V
authors.initials: EV
authors.lastname: Silina
authors.affiliation: N.I. Pirogov Russian National Research University.
authors.forename: S V
authors.initials: SV
authors.lastname: Goryunov
authors.affiliation: N.I. Pirogov Russian National Research University.
authors.forename: V A
authors.initials: VA
authors.lastname: Gorsky
authors.affiliation: M.F. Vladimirsky Moscow Regional Research Clinical Institute.
authors.forename: V T
authors.initials: VT
authors.lastname: Krivikhin
authors.affiliation: I.P. Pavlov First Saint-Petersburg State Medical University.
authors.forename: M S
authors.initials: MS
authors.lastname: Bogomolov
authors.affiliation: I.P. Pavlov First Saint-Petersburg State Medical University.
authors.forename: E R
authors.initials: ER
authors.lastname: Barantsevich
authors.affiliation: Kazan State Medical University, Kazan, Russia.
authors.forename: K A
authors.initials: KA
authors.lastname: Koreiba
mesh_terms: D000368:Aged; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000493:pharmacokinetics; D001682:Biological Availability; D003094:Collagen / Q000008:administration & dosage / Q000493:pharmacokinetics; D017719:Diabetic Foot / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062326:Re-Epithelialization / Q000187:drug effects*; D012720:Severity of Illness Index; D064746:Therapy, Soft Tissue / Q000379:methods; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D003094:Collagen