title: Comparison of 18F-FDG-PET/CT and 18F-FDG-PET/MR imaging in oncology: a systematic review.
abstract: OBJECTIVE
  The aim of this study was to systematically review the literature to evaluate the clinical performance of integrated18F-FDG PET/MR as compared with18F-FDG PET/CT in oncologic imaging.
  
  
  METHODS
  The literature was searched using MEDLINE and EMBASE via OVID. Studies comparing the diagnostic accuracy of integrated18F-FDG PET/MR and18F-FDG PET/CT in the diagnosis, staging/restaging, assessment of treatment response, or evaluation of metastasis in patients with suspected or diagnosed cancers were deemed eligible for inclusion. Risk of bias and applicability concerns were assessed using the QUADAS-2 tool.
  
  
  RESULTS
  Twenty studies met the inclusion criteria. The overall quality of the studies was rated favorably with bias or applicability concerns in a few studies. Our review suggests that18F-FDG PET/MR performs comparably to18F-FDG PET/CT in the detection of local lymph node and distant metastases and superiorly in determining the local extent of tumor. SUV obtained from18F-FDG PET/MR correlated highly with those obtained from18F-FDG PET/CT.
  
  
  CONCLUSIONS
  Based on early evidence,18F-FDG PET/MR is comparable to18F-FDG PET/CT in the clinical scenarios examined in this review. The potential for interchangeability of18F-FDG PET/MR with18F-FDG PET/CT will vary by indication and the body site that is being imaged, with PET scanners integrated with MRI predicted to provide greater detail in the evaluation of local tumor extent, where18F-FDG PET/CT can be limited.
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Hamilton Health Sciences and St. Joseph's Healthcare Hamilton, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada.
authors.forename: Amit
authors.initials: A
authors.lastname: Singnurkar
authors.affiliation: Program in Evidence-Based Care, Cancer Care Ontario, Juravinski Hospital and Cancer Centre, G Wing, 2nd Floor, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada. poonra@mcmaster.ca.
authors.forename: Raymond
authors.initials: R
authors.lastname: Poon
authors.affiliation: Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital and Women's College Hospital, University of Toronto, 610 University Ave., Suite 3-960, Toronto, ON, M5G 2M9, Canada.
authors.forename: Ur
authors.initials: U
authors.lastname: Metser
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: FDG; Multimodal imaging; Oncology; PET/CT; PET/MR