title: The Structure-Antioxidant Activity Relationship of Ferulates.
abstract: The antioxidant activity of ferulic acid (1),iso-ferulic acid (2), coniferyl aldehyde (3), methyl ferulate (4), and ethyl ferulate (5) were investigated using 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric-reducing antioxidant power (FRAP) assays and autoxidation of triacylglycerols of commercially available sunflower oil (TGSO). The compounds tested for ability to scavenge ABTS radical cations was in the order of ferulic acid > coniferyl aldehyde ≈iso-ferulic acid > ethyl ferulate ≈ methyl ferulate. The results of the FRAP assay for ferulic acid,iso-ferulic acid, and coniferyl aldehyde were similar to and higher than those of methyl ferulate and ethyl ferulate. In the lipid system,iso-ferulic acid showed weak antioxidant activity. The other ferulates exhibited much stronger, yet similar, activities.
authors.affiliation: Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland. m.karamac@pan.olsztyn.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Karamać
authors.affiliation: Lipid Chemistry Department, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria. lidiya.koleva@gmail.com.
authors.forename: Lidiya
authors.initials: L
authors.lastname: Koleva
authors.affiliation: Lipid Chemistry Department, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria. vessy.kancheva@abv.bg.
authors.forename: Vessela D
authors.initials: VD
authors.lastname: Kancheva
authors.affiliation: Department of Chemical and Physical Properties of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland. r.amarowicz@pan.olsztyn.pl.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Amarowicz
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry* / Q000494:pharmacology; D003373:Coumaric Acids / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D002109:Caffeic Acids; D003373:Coumaric Acids; C075384:coniferaldehyde; C099085:ethyl ferulate; D000171:Acrolein; C004999:ferulic acid; C530806:methyl ferulate
keywords: 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS); antioxidant activity; ferric-reducing antioxidant power (FRAP); ferulates; lipid oxidation; structure