title: Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han population.
abstract: AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated before. This study investigated the associations between three polymorphisms (rs1130214, rs3730358, and rs2494732) in AKT1 and the risk of development of prostate cancer in the Chinese Han population. Sequenom MassARRAY & iPLEX technology were used to genotype these polymorphisms in 493 Chinese Han patients with prostate cancer and 309 age-matched healthy individuals. Compared to the CC genotype of the rs3730358 polymorphism, the CT genotype of the same polymorphism was strongly associated with a decreased risk of prostate cancer (OR = 0.617, 95%CI = 0.390-0.976, P = 0.037). However, there was no significant difference between the allele frequency of the rs3730358 polymorphism and those of the other two polymorphisms (P > 0.05). Moreover, no significant difference was found in the haplotype analysis (P > 0.05). Our study found that the variant genotype CT of rs3730358 of AKT1 was associated with a decreased risk of prostate cancer, which suggested that this polymorphism could play an important role in the development of the disease.
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: J M
authors.initials: JM
authors.lastname: Liu
authors.affiliation: Department of Radiology, Peking Union Medical College Hospital; Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: S H
authors.initials: SH
authors.lastname: Cheng
authors.affiliation: West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: C
authors.initials: C
authors.lastname: Xia
authors.affiliation: Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: T
authors.initials: T
authors.lastname: Deng
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Y C
authors.initials: YC
authors.lastname: Zhu
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: X
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Huang
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: B H
authors.initials: BH
authors.lastname: Liao
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: D Y
authors.initials: DY
authors.lastname: Luo
authors.affiliation: The Periodical Press of West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Y G
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: T
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: K J
authors.initials: KJ
authors.lastname: Wang
authors.affiliation: West China Hospital, Sichuan University, Chengdu, Sichuan, China huangjinscu@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.
authors.forename: H
authors.initials: H
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics* / Q000378:metabolism
chemical_list: C494918:AKT1 protein, human; D051057:Proto-Oncogene Proteins c-akt