title: Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin.
abstract: α-Catenin is an F-actin-binding protein widely recognized for its role in cell-cell adhesion. However, a growing body of literature indicates that α-catenin is also a nuclear protein. In this study, we show that α-catenin is able to modulate the sensitivity of cells to DNA damage and toxicity. Furthermore, nuclear α-catenin is actively recruited to sites of DNA damage. This recruitment occurs in a β-catenin-dependent manner and requires nuclear actin polymerization. These findings provide mechanistic insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the α-catenin-β-catenin complex in the nucleus.
authors.affiliation: Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA leo.serebryannyy@nih.gov.
authors.forename: Leonid A
authors.identifier: 0000-0003-0213-1779
authors.initials: LA
authors.lastname: Serebryannyy
authors.affiliation: Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Yemelyanov
authors.affiliation: Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Cara J
authors.initials: CJ
authors.lastname: Gottardi
authors.affiliation: Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Primal
authors.initials: P
authors.lastname: de Lanerolle
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair; D004285:Dogs; D006801:Humans; D058105:Polymerization; D000072417:Protein Domains; D051153:Wnt Proteins / Q000378:metabolism; D060449:Wnt Signaling Pathway; D051178:alpha Catenin / Q000737:chemistry / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D000199:Actins; D051153:Wnt Proteins; D051178:alpha Catenin; D051176:beta Catenin
keywords: DNA damage; Nuclear actin; WNT; α-Catenin; β-Catenin