title: Comparison of Accelerated Corneal Collagen Cross-linking Types for Treating Keratoconus.
abstract: To compare the results of different protocols for accelerated corneal collagen cross-linking (CXL) in patients with progressive keratoconus.
  
  
  
  This prospective comparative study involved 40 patients treated with intended UV-A radiance of 5.4 J/cm2in 74 eyes (Group 1) and 42 patients treated with radiance of 7.2 J/cm2in 72 eyes (Group 2). Visual acuity, subjective manifest refraction and corneal topography were analyzed before and 12 months after surgery in both groups. Postoperative complications were also noted. The results of the two protocols were statistically compared.
  
  
  
  There were no statistically significant differences between the groups in uncorrected distance visual acuity, corrected distance visual acuity or corneal topography pre- or postoperatively. The differences in keratometric readings (K apex, SimK1 and SimK2) and refractive results were not significant.
  
  
  
  The application of total intended UV-A radiance of 5.4 J/cm2or 7.2 J/cm2for accelerated CXL in patients with progressive keratoconus resulted in similar refractive and topographic outcomes.
authors.affiliation: a Beyoglu Eye Research and Education Hospital, Department of Ophthalmology , Istanbul Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yıldırım
authors.affiliation: b Kirklareli Government Hospital , Kirklareli , Turkey.
authors.forename: Onur
authors.identifier: 0000-0003-4447-2635
authors.initials: O
authors.lastname: Olcucu
authors.affiliation: a Beyoglu Eye Research and Education Hospital, Department of Ophthalmology , Istanbul Turkey.
authors.forename: Zehra Karaagac
authors.initials: ZK
authors.lastname: Gunaydin
authors.affiliation: a Beyoglu Eye Research and Education Hospital, Department of Ophthalmology , Istanbul Turkey.
authors.forename: Alper
authors.initials: A
authors.lastname: Ağca
authors.affiliation: a Beyoglu Eye Research and Education Hospital, Department of Ophthalmology , Istanbul Turkey.
authors.forename: Engin Bilge
authors.initials: EB
authors.lastname: Ozgurhan
authors.affiliation: a Beyoglu Eye Research and Education Hospital, Department of Ophthalmology , Istanbul Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Alagoz
authors.affiliation: a Beyoglu Eye Research and Education Hospital, Department of Ophthalmology , Istanbul Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Mutaf
authors.affiliation: c Istanbul Medeniyet University , Goztepe Education and Research Hospital, Department of Ophthalmology , Kadıkoy Istanbul Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirok
mesh_terms: D003094:Collagen / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects / Q000473:pathology*; D019781:Corneal Topography; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D011446:Prospective Studies; D012029:Refraction, Ocular; D013997:Time Factors; D016896:Treatment Outcome; D014466:Ultraviolet Rays; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D003094:Collagen
keywords: Corneal collagen cross-linking; keratoconus; ultraviolet A