title: Inhibitory Potential of Constituents from Osmanthus fragrans and Structural Analogues Against Advanced Glycation End Products, α-Amylase, α-Glucosidase, and Oxidative Stress.
abstract: Inhibition of α-amylase and α-glucosidase, advanced glycation end products (AGEs) formation, and oxidative stress by isolated active constituents of Osmanthus fragrans flowers (9,12-octadecadienoic acid and 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one) and their structural analogues were evaluated. 9,12-Octadecadienoic acid was 10.02 and 22.21 times more active against α-amylase and α-glucosidase, respectively, than acarbose and ascorbic acid, followed by 9,12,15-octadecatrienoic acid, 9-octadecenoic acid, 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one, 4-(2,6,6-trimethyl-2-cyclohexenyl)-3-buten-2-one, 1-heptadecanecarboxylic acid, and 1-pentadecanecarboxylic acid. Concerning the inhibition of AGEs formation, similar with data for 2,2'-diphenyl-1-picrylhydrazl radical scavenging activities, 9,12-octadecadienoic acid was 3.54 times more active than aminoguanidine, followed by 9,12,15-octadecatrienoic acid, and 9-octadecenoic acid. These results indicate that 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one, 9,12-octadecadienoic acid and their analogues inhibit α-amylase and α-glucosidase, AGEs formation, and oxidative stress have potential value in alleviating diabetic pathological conditions.
authors.affiliation: Department of Bioenvironmental Chemistry, College of Agricultural and Life Sciences, Chonbuk National University, Jeonju 54896, Korea.
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Department of Bioenvironmental Chemistry, College of Agricultural and Life Sciences, Chonbuk National University, Jeonju 54896, Korea.
authors.forename: Jun-Hwan
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
authors.forename: Namhyun
authors.initials: N
authors.lastname: Chung
authors.affiliation: Department of Bioenvironmental Chemistry, College of Agricultural and Life Sciences, Chonbuk National University, Jeonju 54896, Korea.
authors.forename: Hoi-Seon
authors.initials: HS
authors.lastname: Lee
mesh_terms: D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000517:prevention & control; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D065089:Glycoside Hydrolase Inhibitors / Q000008:administration & dosage*; D031658:Olea / Q000737:chemistry; D018384:Oxidative Stress; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000302:isolation & purification; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D000516:alpha-Amylases