title: Low-Dose Urinary Human Chorionic Gonadotropin Is Effective for Oocyte Maturation inIn VitroFertilization/ Intracytoplasmic Sperm Injection Cycles Independent of Body Mass Index.
abstract: BACKGROUND
  Currently, there is no agreement on the optimal urinary derived human chorionic gonadotropin (u-hCG) dose requirement for initiating final oocyte maturation prior to oocyte collection inin vitrofertilization (IVF), but doses that range from 2500- 15000 IU have been used. We intended to determine whether low dose u-hCG was effective for oocyte maturation in IVF/intracytoplasmic sperm injection (ICSI) cycles independent of body mass index (BMI).
  
  
  METHODS
  We retrospectively evaluated a cohort of 295 women who underwent their first IVF/ICSI cycles between January 2003 and December 2010 at the Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI, USA. Treatment cycles were divided into 3 groups based on BMI (kg/ m2): <25 (n=136), 25- <30 (n=84), and ≥30 (n=75) women. Patients received 5000, 10000 or 15000 IU u-hCG for final maturation prior to oocyte collection. The primary outcome was clinical pregnancy rates (CPRs) and secondary outcome was live birth rates (LBRs).
  
  
  RESULTS
  Only maternal age negatively impacted (P<0.001) CPR [odds ratio (OR=0.85, confidence interval (CI: 0.79-0.91)] and LBR (OR=0.84, CI: 0.78-0.90).
  
  
  CONCLUSIONS
  Administration of lower dose u-hCG was effective for oocyte maturation in IVF and did not affect the CPRs and LBRs irrespective of BMI. Women's BMI need not be taken into consideration in choosing the appropriate dose of u-hCG for final oocyte maturation prior to oocyte collection in IVF. Only maternal age at the time of IVF negatively influenced CPRs and LBRs in this study.
authors.affiliation: 1. Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Luis
authors.initials: L
authors.lastname: R Hoyos
authors.affiliation: 2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Sana
authors.initials: S
authors.lastname: Khan
authors.affiliation: 3. C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Dai
authors.affiliation: 2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Manvinder
authors.initials: M
authors.lastname: Singh
authors.affiliation: 4. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Augusta University, Augusta, GA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: P Diamond
authors.affiliation: 2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: E Puscheck
authors.affiliation: 2. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Awoniyi
authors.initials: A
authors.lastname: O Awonuga
keywords: Body Mass Index; In Vitro Fertilization; Live Birth Rate; Pregnancy Rate; Urinary Human Chorionic Gonadotropin