title: Extensive BMI Gain in Puberty is Associated with Lower Increments in Bone Mineral Density in Estonian Boys with Overweight and Obesity: A 3-Year Longitudinal Study.
abstract: The aim of this 3-year prospective study was to examine changes in bone mineral characteristics during pubertal maturation in boys with different BMI values at the beginning of puberty and with different BMI increments during puberty. 26 boys with overweight and obesity (OWB) and 29 normal weight boys (NWB) were studied yearly for 3 years from the age of 11 years to measure the changes in different bone mineral characteristics. The OWB group was further divided into two subgroups according to extensive or non-extensive BMI increment during 3-year period. OWB had higher (P < 0.01) baseline total body (TB) bone mineral density (BMD), TB bone mineral content (BMC), TB BMC for height, lumbar spine (LS) BMD, and LS BMC compared to NWB. Throughout the study period, OWB gained more TB BMD (P = 0.0001), TB BMC (P = 0.0048), TB BMC for height (P = 0.0124), LS BMD (P = 0.0029), and LS BMC (P = 0.0022) compared to NWB. Also during the study period, TB BMD (P = 0.0065), TB BMC (P = 0.0141), TB BMC for height (P = 0.0199), LS BMD (P = 0.0066), LS apparent volumetric BMD (BMAD) (P = 0.0075), and LS BMC (P = 0.017) increased significantly less in those OWB whose BMI increased more extensively. Extensive BMI gain is associated with lower increments in bone mineral characteristics in boys with overweight and obesity. Unfavorable increment in total body fat mass and percentage during pubertal years could be one reason for that.
authors.affiliation: Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, University of Tartu, Jakobi 5, 50411, Tartu, Estonia. evamengel0@gmail.com.|Children's Clinic of Tartu University Hospital, Tartu, Estonia. evamengel0@gmail.com.
authors.forename: Eva
authors.identifier: 0000-0003-4693-7416
authors.initials: E
authors.lastname: Mengel
authors.affiliation: Faculty of Medicine, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.|Children's Clinic of Tartu University Hospital, Tartu, Estonia.
authors.forename: Vallo
authors.initials: V
authors.lastname: Tillmann
authors.affiliation: Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.
authors.forename: Liina
authors.initials: L
authors.lastname: Remmel
authors.affiliation: Faculty of Medicine, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia.
authors.forename: Pille
authors.initials: P
authors.lastname: Kool
authors.affiliation: Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.
authors.forename: Priit
authors.initials: P
authors.lastname: Purge
authors.affiliation: Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.
authors.forename: Evelin
authors.initials: E
authors.lastname: Lätt
authors.affiliation: Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.
authors.forename: Jaak
authors.initials: J
authors.lastname: Jürimäe
mesh_terms: D000293:Adolescent; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D002648:Child; D004957:Estonia; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000503:physiopathology; D050177:Overweight / Q000503:physiopathology*; D011446:Prospective Studies; D012741:Sexual Maturation / Q000502:physiology*
keywords: Bone mineral apparent density; Bone mineral content; Bone mineral density; Fat mass; Overweight; Pubertal boys