title: Relationship between plasma adropin levels and body composition and lipid characteristics amongst young adolescents in Taiwan.
abstract: Adropin is a 76 amino acid peptide hormone with a molecular weight of 4999.9Da that may be associated with energy homeostasis, insulin resistance and lipid metabolism in mice and human. There is only a few studies that examine plasma adropin levels and body composition in children. This study is to evaluate the relationship between plasma adropin levels, body composition and lipid variables amongst young adolescents in Taiwan. We examined 492 adolescents (269 females and 223 males) ranging from 12 to 15 years old, with a mean age of 13.6 years. Body composition was measured using impedance method by Tanita-BC418. Plasma lipid variables were measured using standard methods and plasma adropin levels were measured using the ELISA method. There was no significant difference in plasma adropin levels between males and females (3.52 vs. 3.58ng/ml). Plasma adropin levels were negatively correlated with fat free mass (r=-0.12, p<0.01). More interestingly, children with higher plasma adropin levels had lower waist-to-hip ratios (WHR) and lower body fat percentage by mass. Furthermore, there is no difference in lipid profiles in high vs. low adropin subjects. Plasma adropin levels are not consistency associated with body composition and no association with lipid variables amongst Taiwanese adolescents. The role of adropin in the development of obesity is still not clear, and further studies are need especially for children.
authors.affiliation: Department of Pathology, National Defense Medical Center, Division of Clinical Pathology, Tri-Service General Hospital, Taipei, Taiwan; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Jin-Biou
authors.initials: JB
authors.lastname: Chang
authors.affiliation: Department of Pathology, National Defense Medical Center, Division of Clinical Pathology, Tri-Service General Hospital, Taipei, Taiwan; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan. Electronic address: chuepi@ndmctsgh.edu.tw.
authors.forename: Nain-Feng
authors.initials: NF
authors.lastname: Chu
authors.affiliation: Department of Pathology, National Defense Medical Center, Division of Clinical Pathology, Tri-Service General Hospital, Taipei, Taiwan; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Fu-Huang
authors.initials: FH
authors.lastname: Lin
authors.affiliation: Department of Pathology, National Defense Medical Center, Division of Clinical Pathology, Tri-Service General Hospital, Taipei, Taiwan; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Jhu-Ting
authors.initials: JT
authors.lastname: Hsu
authors.affiliation: Department of Pathology, National Defense Medical Center, Division of Clinical Pathology, Tri-Service General Hospital, Taipei, Taiwan; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Pi-Yun
authors.initials: PY
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D002648:Child; D004734:Energy Metabolism / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006306:Health Surveys; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids / Q000097:blood*; D008297:Male; D063766:Pediatric Obesity / Q000097:blood / Q000453:epidemiology; D010455:Peptides / Q000097:blood*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D010455:Peptides
keywords: Adropin; Body composition; Children; Lipid