title: New Cytotoxic Alkylated Chalcones from Fatoua villosa.
abstract: Three new alkylated chalcones, villosins A - C (1 - 3), five known analogues, together with ten known coumarins, were isolated from Fatoua villosa. The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D-, 2D-NMR, and MS data. Compounds 1 - 3 showed cytotoxicity against five kinds of human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) with IC50values ranging from 1.4 ± 0.1 to 5.7 ± 0.3 μm.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
authors.forename: Shi-Yun
authors.initials: SY
authors.lastname: Su
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Xue
authors.affiliation: Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., Kunming, 650231, P. R. China.
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
authors.forename: Chun
authors.initials: C
authors.lastname: Lei
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China.
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D000478:Alkylation; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D031746:Digitaria / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D003374:Coumarins
keywords: 
  Fatoua villosa
  ; Alkylated chalcone; Coumarin; Cytotoxic activities; Villosin