title: Falling Leaves Inspired ZnO Nanorods-Nanoslices Hierarchical Structure for Implant Surface Modification with Two Stage Releasing Features.
abstract: Inspired from falling leaves, ZnO nanorods-nanoslices hierarchical structure (NHS) was constructed to modify the surfaces of two widely used implant materials: titanium (Ti) and tantalum (Ta), respectively. By which means, two-stage release of antibacterial active substances were realized to address the clinical importance of long-term broad-spectrum antibacterial activity. At early stages (within 48 h), the NHS exhibited a rapid releasing to kill the bacteria around the implant immediately. At a second stage (over 2 weeks), the NHS exhibited a slow releasing to realize long-term inhibition. The excellent antibacterial activity of ZnO NHS was confirmed once again by animal test in vivo. According to the subsequent experiments, the ZnO NHS coating exhibited the great advantage of high efficiency, low toxicity, and long-term durability, which could be a feasible manner to prevent the abuse of antibiotics on implant-related surgery.
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Liao
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Miao
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.
authors.forename: Zhongbo
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.
authors.forename: Jingyu
authors.initials: J
authors.lastname: Jia
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.
authors.forename: Xigao
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University , Nanchang, Jiangxi 330006, China.|Institute of Translational Medicine, NanChang University , NanChang, Jiangxi 330031, China.
authors.forename: Xiaolei
authors.identifier: http://orcid.org/0000-0003-3403-1174
authors.initials: X
authors.lastname: Wang
keywords: Ta; Ti; antibacterial; implant; nanoarrays; surface modification; zinc oxide