title: Asymmetric Notch Amplification to Secure Stem Cell Identity.
abstract: Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.
authors.affiliation: Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Rossi
authors.affiliation: Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA. Electronic address: cd38@nyu.edu.
authors.forename: Claude
authors.initials: C
authors.lastname: Desplan
mesh_terms: D002454:Cell Differentiation; D058953:Neural Stem Cells; D051880:Receptors, Notch; D015398:Signal Transduction; D013234:Stem Cells
chemical_list: D051880:Receptors, Notch