title: New Resorcinol Derivatives from a Sponge-Derived Fungus Hansfordia sinuosae.
abstract: Ten new resorcinol derivatives named hansfordiols A - J (1 - 10) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. High resolution electron ionization mass spectrometry, FT-IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configurations were established by the modified Mosher's method and their specific optical rotation. The structures of compounds 8 - 10 were featured with various chlorination at aromatic rings. Their antioxidant activities on ABTS, cytotoxicity on the HCT-8, Bel-7402, BGC-823, A549, and A2780 cell lines, and antibacterial activities were evaluated.
authors.affiliation: The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, P. R. China.|Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, P. R. China.
authors.forename: Zehong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Ma
authors.affiliation: The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, P. R. China.
authors.forename: Jianliang
authors.initials: J
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, P. R. China.
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000737:chemistry*; D054879:Halogenation; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology*; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D003603:Cytotoxins; D012118:Resorcinols
keywords: 
  Hansfordia sinuosae
  ; Antibacterial activities; Antioxidant activities; Cytotoxic activities; Resorcinol derivative