title: Early marker of regional left ventricular deformation in patients with hypertrophic cardiomyopathy evaluated by MRI tissue tracking: The effects of myocardial hypertrophy and fibrosis.
abstract: To evaluate the regional left ventricular (LV) myocardial strain of early stage hypertrophic cardiomyopathy (HCM) patients by magnetic resonance (MR) tissue tracking.
  
  
  
  In all, 114 adult HCM patients classified as NYHA I or II and 32 healthy volunteers were enrolled and underwent 3.0T MR examination. Vertical 2-chamber long axis, horizontal 4-chamber, and short axis cine sequence as well as late gadolinium enhancement images (LGE) were scanned. The cardiac function, regional LV tissue tracking variables, end-diastolic wall thickness (EDTH), and LGE extent were measured.
  
  
  
  In the HCM group, 38 were NYHA I and 76 were NYHA II. By regional analysis, peak strain (PS) and peak displacement (PD) with radial, circumferential direction of hypertrophic segments (n = 283) were significantly lower than nonhypertrophic segments (n = 1541) (all P < 0.05). Radial PS was significantly correlated with LVEDTH (r = -0.467, P < 0.0001). Radial PD was negatively associated with LVEDTH (r = -0.331, P < 0.0001). The PS and PD of all directions were decreased in segments with LGE (n = 723) compared with those without LGE (n = 1101) (all P < 0.05). In addition, radial PS and PD were negatively associated with LGE extent (radial PS, r = -0.441; radial PD, r = -0.274; both P < 0.0001). All strain parameters showed excellent inter- and intraobserver agreements.
  
  
  
  Decreased regional LV myocardial strain hypertrophic and fibrotic segments of early-stage HCM patients can be measured by MR tissue tracking based on routine cine images. Moreover, myocardial strain may decrease with the increasing of myocardial hypertrophy as well as fibrosis.
  
  
  
  2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1368-1376.
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Hua-Yan
authors.initials: HY
authors.lastname: Xu
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.|Department of Radiology, Affiliated Hospital of Southwest Medical University, Sichuan, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Yang
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Shi
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Lin-Jun
authors.initials: LJ
authors.lastname: Xie
authors.affiliation: Department of Radiology, National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Radiology, West China Second University Hospital, Sichuan University, Sichuan, P.R. China.
authors.forename: Ying-Kun
authors.initials: YK
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000737:chemistry; D004452:Echocardiography; D005260:Female; D005355:Fibrosis / Q000000981:diagnostic imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D006984:Hypertrophy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D015588:Observer Variation; D015203:Reproducibility of Results; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: early stage hypertrophic cardiomyopathy; magnetic resonance; myocardial fibrosis; myocardial hypertrophy; regional myocardial strain; routine cine images; tissue tracking