title: Highly bioavailable nanocalcium from oyster shell for preventing osteoporosis in rats.
abstract: Oyster shell is one of the foremost natural sources of calcium and is used as an alternative treatment for osteoporosis. In this study, we demonstrated that zinc-activated nanopowdered oyster shell (Zn-NPOS) effectively reduced bone loss compared with powdered oyster shell (POS) in an ovariectomized rat (OVX) model. As a result of nanosizing, the solubility and bioavailability of the oyster shell were greatly improved, and its effectiveness was further enhanced by zinc activation. Bone analysis indicated greater recovery from ovariectomy-induced bone loss following Zn-NPOS treatment. Moreover, Zn-NPOS treatment resulted in higher bone strength and superior trabecular architecture compared with NPOS and POS treatments. Furthermore, Zn-NPOS showed greater efficiency in increasing bone formation and reducing bone resorption markers. Therefore, nanosizing with zinc activation could be a viable strategy for improving the efficiency of oyster shells used for osteoporosis prevention.
authors.affiliation: a Department of Food and Nutrition , Kyung Hee University , Seoul , Korea.
authors.forename: Yun-Kyung
authors.initials: YK
authors.lastname: Lee
authors.affiliation: b Division of Functional Food Research , Korea Food Research Institute , Gyeonggi-do , Korea.
authors.forename: Sung Keun
authors.initials: SK
authors.lastname: Jung
authors.affiliation: a Department of Food and Nutrition , Kyung Hee University , Seoul , Korea.
authors.forename: Yoon Hyuk
authors.initials: YH
authors.lastname: Chang
authors.affiliation: c Department of Food Science and Technology , Sejong University , Seoul , Korea.
authors.forename: Hae-Soo
authors.initials: HS
authors.lastname: Kwak
mesh_terms: D060105:Animal Shells / Q000737:chemistry*; D000818:Animals; D001682:Biological Availability; D015519:Bone Density / Q000187:drug effects*; D002119:Calcium Carbonate / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*; D005260:Female; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000517:prevention & control*; D010125:Ostreidae; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002119:Calcium Carbonate
keywords: Nanopowdered oyster shell; bioavailability; bone; osteoporosis; zinc