title: A Prospective Comparison of Transcutaneous and Serum Bilirubin Within Brief Time Intervals.
abstract: The American Academy of Pediatrics recommends screening newborns ≥35 weeks' gestation with total serum bilirubin (TSB) or transcutaneous bilirubin (TcB) to detect hyperbilirubinemia. Retrospective studies show TcB measurements strongly correlate with TSB; however, few prospective trials document this relationship. Furthermore, Dräger's newest TcB instrument, JM-105, remains unstudied in the United States. We measure TcB on foreheads and sternums of newborns using JM-105 and Bilichek devices within 30 minutes of TSB measurement. We find best overall TcB/TSB correlation with JM-105 on the sternum (mean TcB-TSB difference: -0.21 ± 1.15 mg/dL). Correlations between paired measurements for TcB on the sternum using JM-105 were 0.93 for all TSB levels (n = 178), 0.82 for TSB > 10 (n = 19), 0.69 for TSB > 12 (n = 11), and 0.52 for TSB > 15 (n = 6). TcB accuracy via JM-105 on the sternum significantly differed among races ( P < .001). For 5% of paired measurements, TcB with JM-105 on the sternum underestimated TSB by ≥2 mg/dL, and for <1% by ≥3 mg/dL.
authors.affiliation: 1 North Carolina Children's Hospital, Chapel Hill, NC, USA.
authors.forename: Denise F
authors.initials: DF
authors.lastname: Jones
authors.affiliation: 1 North Carolina Children's Hospital, Chapel Hill, NC, USA.
authors.forename: Abigail R
authors.initials: AR
authors.lastname: McRea
authors.affiliation: 1 North Carolina Children's Hospital, Chapel Hill, NC, USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Knowles
authors.affiliation: 1 North Carolina Children's Hospital, Chapel Hill, NC, USA.
authors.forename: Feng-Chang
authors.initials: FC
authors.lastname: Lin
authors.affiliation: 1 North Carolina Children's Hospital, Chapel Hill, NC, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Burnette
authors.affiliation: 1 North Carolina Children's Hospital, Chapel Hill, NC, USA.
authors.forename: Lara A
authors.initials: LA
authors.lastname: Reller
authors.affiliation: 1 North Carolina Children's Hospital, Chapel Hill, NC, USA.|2 University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Lohr
mesh_terms: D001663:Bilirubin / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood / Q000175:diagnosis*; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening / Q000295:instrumentation* / Q000379:methods*; D011446:Prospective Studies; D015203:Reproducibility of Results
chemical_list: D001663:Bilirubin
keywords: Bilichek; Dräger JM-105; hyperbilirubinemia; jaundice; transcutaneous bilirubin screening