title: Live fast, die soon: cell cycle progression and lifespan in yeast cells.
abstract: Our understanding of lifespan has benefited enormously from the study of a simple model, the yeastSaccharomyces cerevisiae. Although a unicellular organism, yeasts undergo many of the processes directly related with aging that to some extent are conserved in mammalian cells. Nutrient-limiting conditions have been involved in lifespan extension, especially in the case of caloric restriction, which also has a direct impact on cell cycle progression. In fact, other environmental stresses (osmotic, oxidative) that interfere with normal cell cycle progression also influence the lifespan of cells, indicating a relationship between lifespan and cell cycle control. In the present review we compile and discuss new findings related to how cell cycle progression is regulated by other nutrients. We centred this review on the analysis of phosphate, also give some attention to nitrogen, and the impact of these nutrients on lifespan.
authors.affiliation: Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Jiménez
authors.affiliation: Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.
authors.forename: Samuel
authors.initials: S
authors.lastname: Bru
authors.affiliation: Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.
authors.forename: Mariana
authors.initials: M
authors.lastname: Ribeiro
authors.affiliation: Dept. Ciències Bàsiques, Facultat de Medicina i Ciències de la Salut. Universitat Internacional de Catalunya, Barcelona, Catalonia, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Clotet
keywords: Pho85; cell cycle; lifespan; phosphate