title: NPM1 mutation but not RUNX1 mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia lacking recurrent cytogenetic abnormalities in the revised 2016 WHO classification.
authors.affiliation: Department of Pathology, Boston Children's Hospital, 300 Longwood Ave Bader 126.2, Boston, MA, 02115.
authors.forename: Olga K
authors.initials: OK
authors.lastname: Weinberg
authors.affiliation: Division of Hematology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Gibson
authors.affiliation: Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Traci M
authors.initials: TM
authors.lastname: Blonquist
authors.affiliation: Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Donna
authors.initials: D
authors.lastname: Neuberg
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Amory 3, Boston, MA, 02115.
authors.forename: Olga
authors.initials: O
authors.lastname: Pozdnyakova
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Amory 3, Boston, MA, 02115.
authors.forename: Frank
authors.initials: F
authors.lastname: Kuo
authors.affiliation: Division of Hematology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Ebert
authors.affiliation: Department of Pathology, WRN244, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Hasserjian
mesh_terms: D002869:Chromosome Aberrations; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000235:genetics; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D000090243:Nucleophosmin; D012189:Retrospective Studies; D014944:World Health Organization
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; C000716967:NPM1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C493728:RUNX1 protein, human; D000090243:Nucleophosmin