title: Lab-on-a-Chip Proteomic Assays for Psychiatric Disorders.
abstract: Lab-on-a-chip assays allow rapid identification of multiple parameters on an automated user-friendly platform. Here we describe a fully automated multiplex immunoassay and readout in less than 15 min using the Fraunhofer in vitro diagnostics (ivD) platform to enable inexpensive point-of-care profiling of sera or a single drop of blood from patients with various diseases such as psychiatric disorders.
authors.affiliation: Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476, Potsdam, Germany. Harald.Peter@izi-bb.fraunhofer.de.
authors.forename: Harald
authors.initials: H
authors.lastname: Peter
authors.affiliation: Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476, Potsdam, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Wienke
authors.affiliation: Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Rua Monteiro Lobato 255 F/01, CidadeUniversitáriaZeferinoVaz, 13083-862, Campinas, Brazil.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
authors.affiliation: Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476, Potsdam, Germany.
authors.forename: Nikitas
authors.initials: N
authors.lastname: Bistolas
authors.affiliation: Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), Am Mühlenberg 13, 14476, Potsdam, Germany.
authors.forename: Frank F
authors.initials: FF
authors.lastname: Bier
mesh_terms: D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D004867:Equipment Design; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation / Q000379:methods*; D007249:Inflammation / Q000097:blood; D056656:Lab-On-A-Chip Devices; D001523:Mental Disorders / Q000097:blood / Q000175:diagnosis*; D040901:Proteomics / Q000295:instrumentation / Q000379:methods*
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Biomarkers; Early diagnosis; Immunoassay point-of-care; Lab-on-a-chip; Proteomics; Psychiatric disorders