title: Oxidative DNA damage & repair: An introduction.
abstract: This introductory article should be viewed as a prologue to the Free Radical Biology & Medicine Special Issue devoted to the important topic of Oxidatively Damaged DNA and its Repair. This special issue is dedicated to Professor Tomas Lindahl, co-winner of the 2015 Nobel Prize in Chemistry for his seminal discoveries in the area repair of oxidatively damaged DNA. In the past several years it has become abundantly clear that DNA oxidation is a major consequence of life in an oxygen-rich environment. Concomitantly, survival in the presence of oxygen, with the constant threat of deleterious DNA mutations and deletions, has largely been made possible through the evolution of a vast array of DNA repair enzymes. The articles in this Oxidatively Damaged DNA & Repair special issue detail the reactions by which intracellular DNA is oxidatively damaged, and the enzymatic reactions and pathways by which living organisms survive such assaults by repair processes.
authors.affiliation: Département de Médecine Nucléaire et Radiobiologie, Faculté de Médecine de des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4.
authors.forename: Jean
authors.initials: J
authors.lastname: Cadet
authors.affiliation: Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, the University of Southern California, Los Angeles, CA 90089-0191, USA; Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, the University of Southern California, Los Angeles, CA 90089-0191, USA. Electronic address: kelvin@usc.edu.
authors.forename: Kelvin J A
authors.initials: KJA
authors.lastname: Davies
mesh_terms: D000818:Animals; D002621:Chemistry; D004247:DNA / Q000235:genetics*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D009154:Mutation / Q000235:genetics; D009613:Nobel Prize; D018384:Oxidative Stress; D012119:Respiration
chemical_list: D004247:DNA
keywords: DNA damage; DNA oxidation; DNA repair; Nobel Prize; Oxidative stress; Thomas Lindahl