title: Novel Osteobiologics and Biomaterials in the Treatment of Spinal Disorders.
abstract: Spinal osteobiologics have evolved substantially in this century after the development of many product categories such as growth factors, allograft, and stem cells. The indications for the use of novel biologics within spine surgery are rapidly expanding as the mechanism of each is elucidated. While the knowledge base of bone morphogenetic protein increases with each subsequent year, the application of new nanotechnology and cell-based strategies are being reported. This review will discuss the most recent data in novel osteobiologics, and where we could use future study.
authors.affiliation: Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
authors.forename: Wellington K
authors.initials: WK
authors.lastname: Hsu
authors.affiliation: Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Goldstein
authors.affiliation: Department of Orthopaedic Surgery, University of Toronto, Toronto, Canada.
authors.forename: Mohammed F
authors.initials: MF
authors.lastname: Shamji
authors.affiliation: Department of Orthopaedic Surgery, Mount Sinai Hospital, New York, New York.
authors.forename: Sam K
authors.initials: SK
authors.lastname: Cho
authors.affiliation: Department of Neurosurgery, University of Kansas Medical Center, Kansas City, Missouri.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Arnold
authors.affiliation: Department of Orthopaedic Surgery, University of Toronto, Toronto, Canada.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Fehlings
authors.affiliation: Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Tom E
authors.initials: TE
authors.lastname: Mroz
mesh_terms: D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D006801:Humans; D011994:Recombinant Proteins; D013122:Spinal Diseases / Q000601:surgery*; D016212:Transforming Growth Factor beta
chemical_list: D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta
keywords: Bone morphogenetic protein; Nanotechnololgy; Osteobiologics; Spinal biologics; Spinal fusion; TNF-α inhibitors