title: One-step synthesis of nitrogen, boron co-doped fluorescent carbon nanoparticles for glucose detection.
abstract: Heteroatom-doped carbon nanoparticles (CNPs) have attracted considerable attention due to an effective improvement in their intrinsic properties. Here, a facile and simple synthesis of nitrogen, boron co-doped carbon nanoparticles (NB-CNPs) from a sole precursor, 3-aminophenylboronic acid, was performed via a one-step solid-phase approach. Because of the presence of boronic acid, NB-CNPs can be used directly as a fluorescent probe for glucose. Based on a boronic acid-triggered specific reaction, we developed a simple NB-CNP probe without surface modification for the detection of glucose. When glucose was introduced, the fluorescence of NB-CNPs was suppressed through a surface-quenching states mechanism. Obvious fluorescence quenching allowed the highly sensitive determination of glucose with a limit of detection of 1.8 μM. Moreover, the proposed method has been successfully used to detect glucose in urine from people with diabetes, suggesting potential application in sensing glucose.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.|Department of Chemistry, Lanzhou University, Lanzhou, China.
authors.forename: Meijuan
authors.initials: M
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.|Department of Chemistry, Lanzhou University, Lanzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.|Department of Chemistry, Lanzhou University, Lanzhou, China.
authors.forename: Haijuan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.|Department of Chemistry, Lanzhou University, Lanzhou, China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.|Department of Chemistry, Lanzhou University, Lanzhou, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Niu
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.|Department of Chemistry, Lanzhou University, Lanzhou, China.|Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou, China.
authors.forename: Xingguo
authors.initials: X
authors.lastname: Chen
mesh_terms: D001895:Boron / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D003920:Diabetes Mellitus / Q000652:urine; D005453:Fluorescence; D005947:Glucose / Q000032:analysis*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques; D014556:Urine / Q000737:chemistry
chemical_list: D001897:Boronic Acids; C028592:3-aminobenzeneboronic acid; D005947:Glucose; D009584:Nitrogen; D001895:Boron
keywords: NB-CNPs; glucose; people with diabetes; solid phase