title: Chemical interaction mechanism of 10-MDP with zirconia.
abstract: Currently, the functional monomer 10-methacryloyloxy-decyl-dihydrogen-phosphate (10-MDP) was documented to chemically bond to zirconia ceramics. However, little research has been conducted to unravel the underlying mechanisms. This study aimed to assess the chemical interaction and to demonstrate the mechanisms of coordination between 10-MDP and zirconium oxide using1H and31P magic angle spinning (MAS) nuclear magnetic resonance (NMR) and two dimensional (2D)1H →31P heteronuclear correlation (HETCOR) NMR. In addition, shear bond-strength (SBS) tests were conducted to determine the effect of 10-MDP concentration on the bonding effectiveness to zirconia. These SBS tests revealed a 10-MDP concentration-dependent SBS with a minimum of 1-ppb 10-MDP needed.31P-NMR revealed that one P-OH non-deprotonated of the PO3H2group from 10-MDP chemically bonded strongly to zirconia.1H-31P HETCOR NMR indicated that the 10-MDP monomer can be adsorbed onto the zirconia particles by hydrogen bonding between the P=O and Zr-OH groups or via ionic interactions between partially positive Zr and deprotonated 10-MDP (P-O-). The combination of1H NMR and 2D1H-31P HETCOR NMR enabled to describe the different chemical states of the 10-MDP bonds with zirconia; they not only revealed ionic but also hydrogen bonding between 10-MDP and zirconia.
authors.affiliation: Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Nagaoka
authors.affiliation: Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kikta-ku, Okayama 700-8558, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Yoshihara
authors.affiliation: Department of Restorative Dentistry, School of Dentistry, Federal University of Ceará, Fortaleza, Brazil.
authors.forename: Victor Pinheiro
authors.initials: VP
authors.lastname: Feitosa
authors.affiliation: Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Tamada
authors.affiliation: Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kikta-ku, Okayama 700-8558, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Irie
authors.affiliation: Department of Biomedical, Dental Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: KU Leuven (University of Leuven), Department of Oral Health Sciences, BIOMAT &University, Hokkaido Hospitals Leuven, Dentistry, Kapucijnenvoer 7, block A-box 7001, BE-3000 Leuven, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: Van Meerbeek
authors.affiliation: Biomaterials Laboratory, Graduate School of Natural Science and Technology, Okayama University, 3-1-1, Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayakawa