title: Tacrolimus: Does direct glucuronidation matter? An analytical and pharmacological perspective.
authors.affiliation: Rennes University Hospital, Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, 2 rue Henri le Guilloux, 35033 Rennes, France; Rennes 1 University, Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, 2 rue Henri le Guilloux, 35033 Rennes, France; Inserm, CIC-P 1414 Clinical Investigation Center, 2 rue Henri le Guilloux, 35033 Rennes, France. Electronic address: tron.camille@gmail.com.
authors.forename: Camille
authors.initials: C
authors.lastname: Tron
authors.affiliation: Rennes University Hospital, Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, 2 rue Henri le Guilloux, 35033 Rennes, France; Rennes 1 University, Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, 2 rue Henri le Guilloux, 35033 Rennes, France; Inserm, CIC-P 1414 Clinical Investigation Center, 2 rue Henri le Guilloux, 35033 Rennes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Petitcollin
authors.affiliation: Rennes University Hospital, Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, 2 rue Henri le Guilloux, 35033 Rennes, France; Rennes 1 University, Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, 2 rue Henri le Guilloux, 35033 Rennes, France; Inserm, CIC-P 1414 Clinical Investigation Center, 2 rue Henri le Guilloux, 35033 Rennes, France.
authors.forename: Marie-Clémence
authors.initials: MC
authors.lastname: Verdier
authors.affiliation: Inserm, CIC-P 1414 Clinical Investigation Center, 2 rue Henri le Guilloux, 35033 Rennes, France; Rennes University Hospital, Unit of Hepato-Biliary and Digestive Surgery, 2 rue Henri le Guilloux, 35033 Rennes, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Rayar
authors.affiliation: Inserm, CIC-P 1414 Clinical Investigation Center, 2 rue Henri le Guilloux, 35033 Rennes, France; Rennes University Hospital, Unit of Hepato-Biliary and Digestive Surgery, 2 rue Henri le Guilloux, 35033 Rennes, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Beaurepaire
authors.affiliation: Inserm, CIC-P 1414 Clinical Investigation Center, 2 rue Henri le Guilloux, 35033 Rennes, France; Rennes University Hospital, Unit of Hepato-Biliary and Digestive Surgery, 2 rue Henri le Guilloux, 35033 Rennes, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Boudjema
authors.affiliation: Rennes University Hospital, Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, 2 rue Henri le Guilloux, 35033 Rennes, France; Rennes 1 University, Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, 2 rue Henri le Guilloux, 35033 Rennes, France; Inserm, CIC-P 1414 Clinical Investigation Center, 2 rue Henri le Guilloux, 35033 Rennes, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Bellissant
authors.affiliation: Rennes University Hospital, Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, 2 rue Henri le Guilloux, 35033 Rennes, France; Rennes 1 University, Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, 2 rue Henri le Guilloux, 35033 Rennes, France; Inserm, CIC-P 1414 Clinical Investigation Center, 2 rue Henri le Guilloux, 35033 Rennes, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Lemaitre
mesh_terms: D016903:Drug Monitoring / Q000379:methods; D020719:Glucuronides / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016559:Tacrolimus / Q000493:pharmacokinetics* / Q000627:therapeutic use*
chemical_list: D020719:Glucuronides; D007166:Immunosuppressive Agents; D014453:Glucuronosyltransferase; D016559:Tacrolimus