title: Radiographic Findings in Patients with Medication-Related Osteonecrosis of the Jaw.
abstract: A retrospective study was conducted of the records and panoramic radiographs of 35 patients treated with bisphosphonates (BP) and diagnosed with MRONJ. Panoramic radiography was used for evaluation, by two examiners, the following findings were subject of search: osteolysis (OT), cortical bone erosion (EC), bone sclerosis focal (FS) and diffuse (DS), bone sequestration (BS), thickening of lamina dura (TD), prominence of the inferior alveolar nerve canal (IAN), persisting alveolar sockets (SK), and the presence of a pathological fracture (PF). Medical information and staging were also recorded in order to correlate with radiographic findings. Bone sclerosis was the most frequent alteration, followed by OT and TD. The mandible was more affected than the maxilla. There was no significant difference between genders or significant correlation between the number of injuries with age and duration of BP usage. Considering the association between the radiographic findings and MRONJ staging, EC was predominant in stage 3 and DS in stage 2. IAN and PF demonstrated greater association with stage 3. In conclusion, the higher the clinical staging, the greater the severity of the bone alteration. Panoramic radiographic examination is a useful screening tool in patients submitted to antiresorptive therapy.
authors.affiliation: Department of Oral Surgery, Universidade do Sagrado Coração, Bauru, SP, Brazil.
authors.forename: Camila Lopes
authors.identifier: 0000-0001-9545-6809
authors.initials: CL
authors.lastname: Cardoso
authors.affiliation: Department of Oral Surgery, Universidade do Sagrado Coração, Bauru, SP, Brazil.
authors.forename: Carolina Arrabal
authors.initials: CA
authors.lastname: Barros
authors.affiliation: Department of Oral Surgery, Universidade do Sagrado Coração, Bauru, SP, Brazil.
authors.forename: Cláudia
authors.initials: C
authors.lastname: Curra
authors.affiliation: Department of Oral Radiology, Universidade de São Paulo, São Paulo, SP, Brazil.
authors.forename: Luciana Maria Paes da Silva Ramos
authors.initials: LM
authors.lastname: Fernandes
authors.affiliation: Department of Biostatistics, Universidade do Sagrado Coração, Bauru, SP, Brazil.
authors.forename: Solange de Oliveira Braga
authors.initials: SO
authors.lastname: Franzolin
authors.affiliation: Department of Biostatistics, Universidade do Sagrado Coração, Bauru, SP, Brazil.
authors.forename: Joel Santiago Ferreira
authors.initials: JS
authors.lastname: Júnior
authors.affiliation: Department of Oral Surgery, Universidade do Sagrado Coração, Bauru, SP, Brazil.
authors.forename: Carlos César
authors.initials: CC
authors.lastname: De Antoni
authors.affiliation: Department of Stomatology, Hospital Santa Catarina, São Paulo, SP, Brazil.
authors.forename: Marcos Martins
authors.initials: MM
authors.lastname: Curi