title: Influence of Left Atrial Function on Exercise Capacity and Left Ventricular Function in Patients With Heart Failure and Preserved Ejection Fraction.
abstract: Although left atrial (LA) dysfunction is common in heart failure with preserved ejection fraction (HFpEF), its functional implications beyond the reflection of left ventricular (LV) pathology are not well understood. The aim of this study was to further characterize LA function in HFpEF patients.
  
  
  
  We performed cardiac magnetic resonance myocardial feature tracking in 22 patients with HFpEF and 12 patients without HFpEF. LA reservoir strain, LA conduit strain, and LA booster pump strain were quantified. Peak oxygen uptake (VO2max) was determined. Invasive pressure-volume loops were obtained to evaluate LV diastolic properties. LV early filling was determined from LV volume-time curves as derived from cardiac magnetic resonance. LA reservoir and conduit strain were significantly lower in HFpEF (LA reservoir strain, 22±7% versus 29±6%,P=0.04; LA conduit strain, -9±5% versus -15±4%,P<0.01). Patients with HFpEF showed lower oxygen uptake (17±6 versus 29±8 mL/(kg min);P<0.01). Strain measurement for LA conduit function was strongly associated with VO2max (r=0.80;P<0.01). On multivariable regression analysis, LA conduit strain emerged as strongest predictor for VO2max even after inclusion of LV stiffness and relaxation time (β=0.80;P<0.01). LA conduit strain correlated with the volume of early ventricular filling (r=0.67;P<0.01), but not LV stiffness constant β (-0.34;P=0.051) or relaxation constant τ (r=-0.33;P=0.06).
  
  
  
  Cardiac magnetic resonance myocardial feature tracking-derived conduit strain is significantly impaired in HFpEF and associated with exercise intolerance. Impaired conduit function is associated with impaired early ventricular filling, as potential mechanism leading to impaired oxygen uptake. Our results propose that impaired LA conduit function represents a distinct feature of HFpEF, independent of LV stiffness and relaxation.
  
  
  
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT02459626.
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Maximilian
authors.initials: M
authors.lastname: von Roeder
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Karl-Philipp
authors.initials: KP
authors.lastname: Rommel
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Johannes Tammo
authors.initials: JT
authors.lastname: Kowallick
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Stephan
authors.initials: S
authors.lastname: Blazek
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Christian
authors.initials: C
authors.lastname: Besler
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Karl
authors.initials: K
authors.lastname: Fengler
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Joachim
authors.initials: J
authors.lastname: Lotz
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Gerd
authors.initials: G
authors.lastname: Hasenfuß
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Christian
authors.initials: C
authors.lastname: Lücke
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Matthias
authors.initials: M
authors.lastname: Gutberlet
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schuler
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.).
authors.forename: Andreas
authors.initials: A
authors.lastname: Schuster
authors.affiliation: From the Department of Internal Medicine/Cardiology (M.v.R., K.-P.R., S.B., C.B., K.F., G.S., P.L.) and Department of Radiology (C.L., M.G.), University of Leipzig, Heart Center, Germany; Department of Cardiology and Pneumology (G.H., A.S.) and Institute for Diagnostic and Interventional Radiology (J.T.K., J.L.), Georg-August University, Göttingen, Germany; and DZHK (German Centre for Cardiovascular Research), Berlin, Germany (J.T.K., J.L., G.H., A.S.). Philipp.Lurz@gmx.de.
authors.forename: Philipp
authors.initials: P
authors.lastname: Lurz
mesh_terms: D000328:Adult; D000368:Aged; D016279:Atrial Function, Left; D062185:Atrial Pressure; D006328:Cardiac Catheterization; D016022:Case-Control Studies; D018619:Echocardiography, Doppler, Pulsed; D017079:Exercise Tolerance; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009200:Myocardial Contraction; D010101:Oxygen Consumption; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D013997:Time Factors; D016277:Ventricular Function, Left
keywords: atrial function; exercise test; heart failure, diastolic; magnetic resonance imaging