title: Corn-based vaccines: current status and prospects.
abstract: Corn is an attractive host for vaccine production and oral delivery. The present review provides the current outlook and perspectives for this field. Among seed-crops, corn represents a key source of biomass for food, fuel production, and other applications. Since the beginning of the development of plant-based vaccines, corn was explored for the production and delivery of vaccines. About a dozen of pathogens have been studied under this technology with distinct degrees of development. A vaccine prototype against enterotoxigenic Escherichia coli was evaluated in a phase I clinical trial and several candidates targeting bacterial and viral diseases are under preclinical evaluation. The present review provides an updated outlook on this topic highlighting the employed expression strategies; perspectives for the field are also provided.
authors.affiliation: Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, San Luis Potosí, SLP, 78210, Mexico. rosales.s@fcq.uaslp.mx.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosales-Mendoza
authors.affiliation: Centro de Investigaciones Biológicas del Noroeste, SC, Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, BCS, 23096, Mexico.
authors.forename: Cristhian
authors.initials: C
authors.lastname: Sández-Robledo
authors.affiliation: Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, San Luis Potosí, SLP, 78210, Mexico.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Bañuelos-Hernández
authors.affiliation: Centro de Investigaciones Biológicas del Noroeste, SC, Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, BCS, 23096, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Angulo
mesh_terms: D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D054307:Enterotoxigenic Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000517:prevention & control*; D015870:Gene Expression; D030821:Plants, Genetically Modified; D012639:Seeds / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D003313:Zea mays / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D001428:Bacterial Vaccines; D014765:Viral Vaccines
keywords: Gamma zein promoter; Maize; Molecular farming; Oral immunization; Seed; Vaccine; Vacuole targeting; Zea mays