title: Role of tissue expansion in abdominal wall reconstruction: A systematic evidence-based review.
abstract: BACKGROUND
  Tissue expanders (TEs) can be used to assist primary closure of complicated hernias and large abdominal wall defects. However, there is no consensus regarding the optimal technique, use, or associated risk of TE in abdominal wall reconstruction.
  
  
  METHODS
  A systematic search of PubMed and Embase databases was conducted to identify articles reporting abdominal wall reconstruction with TE techniques. English articles published between 1980 and 2016 were included on the basis of the following inclusion criteria: two-stage TE surgical technique, >3 cases, reporting of postoperative complications, hernia recurrence, and patient-based clinical data.
  
  
  RESULTS
  Fourteen studies containing 103 patients (85 adults and 18 children) were identified for analysis. Most patients presented with a skin-grafted ventral hernia (n = 86). The etiology of the hernia was from trauma or prior abdominal surgery. The remaining patients had TE placed before organ transplantation (n = 12) or for congenital abdominal wall defects (n = 5). The location for expander placement was subcutaneous (n = 74), between the internal and external obliques (n = 26), posterior to the rectus sheath (n = 2), and intra-peritoneal (n = 1). Postoperative infections and implant-related problems were the most commonly reported complications after Stage I. The most common complication after Stage II was recurrent hernia, which was observed in 12 patients (11.7%). Five patients with TE died. Complications and mortality were more prevalent in children, immunosuppressed patients, and those with chronic illnesses.
  
  
  CONCLUSIONS
  Tissue expansion for abdominal wall reconstruction can be successfully used for a variety of carefully selected patients with an acceptable complication and risk profile.
authors.affiliation: Department of Head, Neck and Plastic Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, USA.
authors.forename: Kimberly E
authors.initials: KE
authors.lastname: Wooten
authors.affiliation: Department of Head, Neck and Plastic Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, USA. Electronic address: cemile.ozturk@roswellpark.org.
authors.forename: Cemile Nurdan
authors.initials: CN
authors.lastname: Ozturk
authors.affiliation: Department of Head, Neck and Plastic Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, USA.
authors.forename: Can
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Main Street, Buffalo, NY, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Laub
authors.affiliation: University Libraries, State University of New York at Buffalo, Main Street, Buffalo, NY, USA.
authors.forename: Nell
authors.initials: N
authors.lastname: Aronoff
authors.affiliation: Department of Plastic Surgery, Cleveland Clinic, Euclid Ave, Cleveland, OH, USA.
authors.forename: Raffi
authors.initials: R
authors.lastname: Gurunluoglu
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000328:Adult; D002648:Child; D006555:Hernia, Ventral / Q000601:surgery*; D059685:Herniorrhaphy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D011182:Postoperative Care; D011183:Postoperative Complications; D012008:Recurrence; D012086:Reoperation; D012307:Risk Factors; D015626:Tissue Expansion / Q000009:adverse effects / Q000379:methods*
keywords: Abdominal wall reconstruction; Component separation; Tissue expanders; Tissue expansion; Transplantation; Ventral hernia