title: A new cineol derivative, polyphenols and norterpenoids from Saharan myrtle tea (Myrtus nivellei): Isolation, structure determination, quantitative determination and antioxidant activity.
abstract: The phytochemical profile of decoction and infusion, obtained from the dried leaves of M. nivellei, consumed as tea in Saharan region, was characterized by UHPLC-PDA-HRMS. Fourteen compounds were characterized and, to confirm the proposed structures a preparative procedure followed by NMR spectroscopy was applied. Compound 3 (2-hydroxy-1,8-cineole disaccharide) was a never reported whereas a bicyclic monoterpenoid glucoside (2), two ionol glucosides (1 and 12), a tri-galloylquinic acid (4), two flavonol glycosides (5 and 9), and a tetra-galloylglucose (7), were reported in Myrtus spp. for the first time. Five flavonol O-glycosides (6, 8, 10-11, and 14) togheter a flavonol (13) were also identified. Quantitative determination of phenolic constituents from decoction and infusion has been performed by HPLC-UV-PDA. The phenolic content was found to be 150.5 and 102.6mg/g in decoction and infusion corresponding to 73.8 and 23.6mg/100mL of a single tea cup, respectively. Myricetin 3-O-β-d-(6″-galloyl)glucopyranoside (5), isomyricitrin (6) and myricitrin (8) were the compounds present in the highest concentration. The free-radical scavenging activities of teas and isolated compounds was measured by the DPPH assay and compared with the values of other commonly used herbal teas (green and black teas). Decoction displayed higher potency in scavenging free-radicals than the infusion and green and black teas.
authors.affiliation: USTHB, University of Sciences and Technology Houari Boumediene, Faculty of Chemistry, BP 32 El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria.
authors.forename: Amira
authors.initials: A
authors.lastname: Mansour
authors.affiliation: Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132 84084 Fisciano, SA, Italy.
authors.forename: Rita
authors.initials: R
authors.lastname: Celano
authors.affiliation: Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132 84084 Fisciano, SA, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Mencherini
authors.affiliation: Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132 84084 Fisciano, SA, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Picerno
authors.affiliation: Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132 84084 Fisciano, SA, Italy.
authors.forename: Anna Lisa
authors.initials: AL
authors.lastname: Piccinelli
authors.affiliation: USTHB, University of Sciences and Technology Houari Boumediene, Faculty of Chemistry, BP 32 El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria.
authors.forename: Yazid
authors.initials: Y
authors.lastname: Foudil-Cherif
authors.affiliation: University of Szeged, Faculty of Pharmacy, Department of Pharmacognosy, 6720 Szeged, Eötvös u. 6, Magyarország, Hungary.
authors.forename: Dezső
authors.initials: D
authors.lastname: Csupor
authors.affiliation: INRF National Institute of Forest Research, BP 37 Bainem, Algeria; USTHB, University of Sciences and Technology Houari Boumediene, Faculty of Biological Sciences, BP 32 El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria.
authors.forename: Ghania
authors.initials: G
authors.lastname: Rahili
authors.affiliation: USTHB, University of Sciences and Technology Houari Boumediene, Faculty of Biological Sciences, BP 32 El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria.
authors.forename: Nassima
authors.initials: N
authors.lastname: Yahi
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19395-5487, Tehran, Iran.
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
authors.affiliation: Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132 84084 Fisciano, SA, Italy.
authors.forename: Rita Patrizia
authors.initials: RP
authors.lastname: Aquino
authors.affiliation: Dipartimento di Farmacia, University of Salerno, Via Giovanni Paolo II, 132 84084 Fisciano, SA, Italy. Electronic address: rastrelli@unisa.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Rastrelli
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D003511:Cyclohexanols / Q000737:chemistry* / Q000302:isolation & purification; D000077591:Eucalyptol; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification; D031651:Myrtus / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification; D000069459:Teas, Herbal; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000975:Antioxidants; D003511:Cyclohexanols; D005419:Flavonoids; D044948:Flavonols; D005960:Glucosides; D006027:Glycosides; D039821:Monoterpenes; D059808:Polyphenols; D000069459:Teas, Herbal; D013729:Terpenes; C008577:myricitrin; D000077591:Eucalyptol
keywords: 2-Hydroxy-1,8-cineole disaccharide; Free-radical scavenging activity; Myricetin glycoside; Myrtus nivellei; NMR; UHPLC-PDA-ESI-HRMS