title: Preoperative MRI features associated with lymphovascular invasion in node-negative invasive breast cancer: A propensity-matched analysis.
abstract: In node-negative disease, the presence of lymphovascular invasion (LVI) is reported to be an unfavorable prognostic factor. Thus, the aim of this study was to evaluate whether preoperative breast MRI features are associated with LVI in patients with node-negative invasive breast cancer by a propensity-matched analysis.
  
  
  
  Among 389 patients with node-negative invasive ductal breast cancer who had preoperative breast 3.0 Tesla MRI with precontrast T2-weighted fat-suppressed, pre- and dynamic postcontrast T1-weighted fat-suppressed sequences, 61 patients with LVI (LVI group) were matched with 183 patients without LVI (no LVI group) at a ratio of 1:3 in terms of age, histologic grade, tumor size, and hormone receptor status. Two radiologists reviewed the MRI features, following profiles of focal breast edema (peritumoral, prepectoral, subcutaneous), intratumoral T2 signal intensity, adjacent vessel sign, and increased ipsilateral whole-breast vascularity, in addition to 2013 Breast Imaging Reporting and Data System lexicon.
  
  
  
  The presence of peritumoral edema (45.9% [28/61] versus 30.6% [56/183], P = 0.030) and adjacent vessel sign (82.0% [50/61] versus 68.3% [125/183], P = 0.041) was significantly associated with LVI. Prepectoral edema was also more frequently observed in the LVI group than in the no LVI group with borderline significance (26.2% [16/61] versus 15.3% [28/183], P = 0.055). In cases of nonmass enhancement, regional enhancement was more frequently found in the LVI group than in the no LVI group (60.0% [3/4] versus 5.9% [1/4], P = 0.042).
  
  
  
  Preoperative breast MRI features may be associated with LVI in patients with node-negative invasive breast cancer.
  
  
  
  3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2017;46:1037-1044.
authors.affiliation: Department of Radiology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Hyejin
authors.initials: H
authors.lastname: Cheon
authors.affiliation: Department of Radiology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Radiology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: So Mi
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Radiology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Seung Hyun
authors.initials: SH
authors.lastname: Cho
authors.affiliation: Department of Radiology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Shin
authors.affiliation: Department of Radiology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Gab Chul
authors.initials: GC
authors.lastname: Kim
authors.affiliation: Department of Pathology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Park
authors.affiliation: Department of Radiology, Kyungpook National University Medical Center, Daegu, Korea.
authors.forename: Won Hwa
authors.identifier: 0000-0001-7137-9968
authors.initials: WH
authors.lastname: Kim
mesh_terms: D001940:Breast / Q000000981:diagnostic imaging / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011300:Preoperative Care / Q000379:methods*; D011379:Prognosis; D057216:Propensity Score; D012189:Retrospective Studies
keywords: T2-weighted images; breast neoplasms; lymphovascular invasion; magnetic resonance imaging; propensity score