title: Periodic olfactory assessment in patients undergoing skull base surgery with preservation of the olfactory strip.
abstract: Others have reported olfactory disturbances following endoscopic approaches to the skull base. However, there is a lack of consensus on the extent and duration of dysfunction. This study aimed to compare our results with previously published work and to validate the olfactory strip-sparing approach.
  
  
  
  Prospective study to assess olfaction in 50 patients scheduled to undergo resection of skull base tumors via extended endoscopic approaches.
  
  
  
  Patients were divided into two groups. Group I had a nasoseptal flap (NSF), and group II included patients in whom rescue flaps were performed bilaterally. Olfactory outcomes were assessed using repeated University of Pennsylvania Smell Identification Test at baseline, 6 weeks, 3 months, and 6 months following surgery.
  
  
  
  Ultimately, 42 patients (seven group I and 35 group II) were available for assessment. Scores for group I were lower than at baseline at 6 weeks postoperatively (30.71 ± 5.5 vs. 24.5 ± 5.4; P = .05). However, by the third postoperative month the scores had improved to a level that was not significantly different from baseline (29.0 ± 3.7; P = .5). At 6 months, the score was 30.0 ± 3.9. Patients in group II showed no difference between their baseline and 6-week scores (31.5 ± 5.3 vs. 29.7 ± 5.9; P = .16). Six months postoperatively, the score was significantly higher (33.78 ± 3.6; P = .04).
  
  
  
  Expanded endoscopic approaches to skull base tumors involving reconstruction with an NSF are associated with a short-term negative impact on olfaction. Olfaction does not seem to be affected by the surgical resection of pituitary adenomas associated with rescue flaps. Identification of the olfactory epithelium and meticulous harvesting of the NSF are critical to preserve olfaction.
  
  
  
  4. Laryngoscope, 127:1970-1975, 2017.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.
authors.forename: Smita
authors.initials: S
authors.lastname: Upadhyay
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.
authors.forename: Lamia
authors.initials: L
authors.lastname: Buohliqah
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.
authors.forename: Ricardo L L
authors.initials: RLL
authors.lastname: Dolci
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.|Neurosurgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Otto
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.|Neurosurgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Prevedello
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.|Neurosurgery, Wexner Medical Center at Ohio State University, Columbus, Ohio, U.S.A.
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Carrau
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009300:Nasal Septum / Q000503:physiopathology / Q000601:surgery; D057605:Natural Orifice Endoscopic Surgery / Q000009:adverse effects* / Q000379:methods; D000857:Olfaction Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D009831:Olfactory Mucosa / Q000503:physiopathology / Q000601:surgery; D010911:Pituitary Neoplasms / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D011184:Postoperative Period; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000009:adverse effects* / Q000379:methods; D019291:Skull Base / Q000601:surgery*; D019292:Skull Base Neoplasms / Q000601:surgery; D012903:Smell / Q000502:physiology; D013524:Surgical Flaps / Q000601:surgery; D016896:Treatment Outcome
keywords: Olfaction; endoscopic endonasal; nasoseptal flap; rescue flap; skull base tumors