title: Spontaneous DNA damage propels tumorigenicity.
abstract: High levels of endogenously generated DNA damage drive oncogenesis, sustain malignant progression and increase therapy resistance. In a paper recently published in Cell Research, Liu and colleagues added additional insights into this topic by uncovering a novel intrinsic source of double-strand breaks that fosters the aggressiveness and stemness of malignant cells.
authors.affiliation: Department of Biology, University of Rome "Tor Vergata", Rome 00133, Italy.|Regina Elena National Cancer Institute, Rome 00144, Italy.
authors.forename: Ilio
authors.initials: I
authors.lastname: Vitale
authors.affiliation: Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris 75006, France.|Université Pierre et Marie Curie/Paris VI, Paris 75006, France.|Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris 75006, France.|INSERM, U1138, Paris 75006, France.|Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif 94805, France.|Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris 75015, France.|Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm 17176, Sweden.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D004247:DNA; D053903:DNA Breaks, Double-Stranded; D004249:DNA Damage; D004260:DNA Repair
chemical_list: D004247:DNA