title: Body mass index and outcome of out-of-hospital cardiac arrest patients not treated by targeted temperature management.
abstract: BACKGROUND
  Obesity has been demonstrated to increase the risk of out-of-hospital cardiac arrest (OHCA) and may influence the quality and effectiveness of cardiopulmonary resuscitation. Our aim was to investigate the association between body mass index (BMI) and the outcome of OHCA victims not treated by targeted temperature management.
  
  
  METHODS
  This was a prospective observational study of OHCA patients. The patients were categorized according to BMI into two groups: the normal BMI group (nBMI) and the elevated BMI group (eBMI). The primary endpoint was return of spontaneous circulation (ROSC), while secondary outcomes were survival to intensive care unit (ICU) admission and survival to ICU discharge.
  
  
  RESULTS
  Of the initial 99 patients who were transported to the Emergency Department, 84 (85%) were included in the study. Mean BMI was 29.8kg/m2. Thirteen (15.5%) patients achieved ROSC and were admitted to the ICU, with the mean duration of ICU length of stay being 6.7±4.9days. Survival to ICU admission and ICU discharge were higher in the eBMI group (17.6% vs. 6.25%, p=0.010 and 10.3% vs. 6.25%, p=0.021, respectively). Survival to ICU discharge was higher in ventricular fibrillation patients compared to patients with non-shockable rhythms, irrespectively of their BMI (p=0.002). All patients that survived to ICU discharge did so with a cerebral performance category score of 2.
  
  
  CONCLUSIONS
  Survival to ICU admission and ICU discharge were higher in the eBMI group.
authors.affiliation: National and Kapodistrian University of Athens, Medical School, Postgraduate Study Program (MSc) "Cardiopulmonary Resuscitation", Athens, Greece.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Galatianou
authors.affiliation: National and Kapodistrian University of Athens, Medical School, "Evaggelismos" University Hospital, 1st Department of Intensive Care, Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Karlis
authors.affiliation: Psychiatric Hospital of Attica, Athens, Greece.
authors.forename: Aristotelis
authors.initials: A
authors.lastname: Apostolopoulos
authors.affiliation: "Agios Panteleimon" General Hospital of Nikaia, Department of Neurosurgery, Piraeus, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Intas
authors.affiliation: "Agios Panteleimon" General Hospital of Nikaia, Department of Neurosurgery, Piraeus, Greece.
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Chalari
authors.affiliation: Midwestern University of Chicago, College of Pharmacy, Department of Pharmaceutical Sciences, IL 60515, USA.
authors.forename: Anil
authors.initials: A
authors.lastname: Gulati
authors.affiliation: Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; National and Kapodistrian University of Athens, Medical School, Aretaieio Hospital, Department of Neonatology, Athens, Greece.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Iacovidou
authors.affiliation: National and Kapodistrian University of Athens, Medical School, Postgraduate Study Program (MSc) "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece. Electronic address: thanoschalkias@yahoo.gr.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Chalkias
authors.affiliation: Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece; European University Cyprus, School of Medicine, Nicosia, Cyprus.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Xanthos
mesh_terms: D000368:Aged; D015992:Body Mass Index; D001831:Body Temperature; D016887:Cardiopulmonary Resuscitation; D004632:Emergency Medical Services; D004636:Emergency Service, Hospital; D005260:Female; D006115:Greece; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D058687:Out-of-Hospital Cardiac Arrest / Q000401:mortality* / Q000628:therapy*; D011446:Prospective Studies; D015996:Survival Rate; D062606:Tertiary Care Centers; D016896:Treatment Outcome
keywords: Body mass index; Cardiopulmonary resuscitation; Out-of-hospital cardiac arrest; Survival