title: Metal-Organic Framework (MOF)-Based Drug/Cargo Delivery and Cancer Therapy.
abstract: Metal-organic frameworks (MOFs)-an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers-have attracted increasing attention in recent years. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.
authors.affiliation: International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
authors.forename: Ming-Xue
authors.initials: MX
authors.lastname: Wu
authors.affiliation: International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, China.
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Yang
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D000073396:Metal-Organic Frameworks / Q000737:chemistry*; D009369:Neoplasms; D016062:Porosity
chemical_list: D000073396:Metal-Organic Frameworks
keywords: MOFs; controlled drug release; nanomedicine; nanoparticles; stimuli-responsive