title: 18F-Choline PET/CT scan in staging and biochemical recurrence in prostate cancer patients: Changes in classification and radiotherapy planning.
abstract: OBJECTIVE
  To evaluate the role of the18F-Choline PET/CT in prostate cancer management when detecting distant disease in planning radiotherapy and staging and to evaluate the therapy changes guided by PET/TC results.
  
  
  METHODS
  A retrospective evaluation was performed on18F-Choline PET/CT scans of patients with prostate cancer. Staging and planning radiotherapy scans were selected in patients with at least 9 months follow up. There was a total of 56 studies, 33 (58.93%) for staging, and 23 (41.07%) for planning radiotherapy. All scans were obtained using a hybrid PET/CT scanner. The PET/CT acquisition protocol consisted of a dual-phase procedure after the administration of an intravenous injection of 296-370MBq of18F-Choline.
  
  
  RESULTS
  There were 43 out of 56 (76.8%) scans considered as positive, and 13 (23.2%) were negative. The TNM staging was changed in 13 (23.2%) scans. The PET/CT findings ruled out distant disease in 4 out of 13 scans, and unknown distant disease was detected in 9 (69.3%) scans.
  
  
  CONCLUSIONS
  18F-Choline PET/CT is a useful technique for detecting unknown distant disease in prostate cancer when staging and planning radiotherapy. The inclusion of18F-choline PET/CT should be considered in prostate cancer management protocols.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Puerta de Hierro, Majadahonda, España. Electronic address: jcardonaarbonies@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Cardona Arboniés
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Puerta de Hierro, Majadahonda, España.
authors.forename: B
authors.initials: B
authors.lastname: Rodríguez Alfonso
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Puerta de Hierro, Majadahonda, España.
authors.forename: J
authors.initials: J
authors.lastname: Mucientes Rasilla
authors.affiliation: Servicio de Urología, Hospital Universitario Puerta de Hierro, Majadahonda, España.
authors.forename: C
authors.initials: C
authors.lastname: Martínez Ballesteros
authors.affiliation: Servicio de Oncología Radioterápica, Hospital Universitario Puerta de Hierro, Majadahonda, España.
authors.forename: I
authors.initials: I
authors.lastname: Zapata Paz
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Puerta de Hierro, Majadahonda, España.
authors.forename: A
authors.initials: A
authors.lastname: Prieto Soriano
authors.affiliation: Servicio de Urología, Hospital Universitario Puerta de Hierro, Majadahonda, España.
authors.forename: J
authors.initials: J
authors.lastname: Carballido Rodriguez
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Puerta de Hierro, Majadahonda, España.
authors.forename: M
authors.initials: M
authors.lastname: Mitjavila Casanovas
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002794:Choline / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted; D012189:Retrospective Studies
chemical_list: C516370:fluoromethylcholine; D002794:Choline
keywords: Biochemical recurrence; Choline; Colina; Cáncer de próstata; Estadificación; PET/CT; PET/TC; Planificación de radioterapia; Prostate cancer; Radiotherapy planning; Recurrencia bioquímica; Staging