title: Institutional profile: University of Florida Health Personalized Medicine Program.
abstract: The University of Florida (UF) Health Personalized Medicine Program launched in 2012 with CYP2C19 genotyping for clopidogrel response at UF Health Shands Hospital. We have since expanded CYP2C19 genotyping to UF Health Jacksonville and established the infrastructure at UF Health to support clinical implementation for five additional gene-drug pairs: TPMT-thiopurines, IFNL3 (IL28B)-PEG IFN-α-based regimens, CYP2D6-opioids, CYP2D6/CYP2C19-antidepressants and CYP2C19-proton pump inhibitors. We are contributing to the evidence based on outcomes with genotype-guided therapy through pragmatic studies of our clinical implementations. In addition, we have developed a broad array of educational programs for providers, trainees and students that incorporate personal genotype evaluation to enhance participant learning.
authors.affiliation: Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.|Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.|Clinical & Translational Science Institute, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Larisa H
authors.initials: LH
authors.lastname: Cavallari
authors.affiliation: Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.|Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.|Clinical & Translational Science Institute, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Kristin W
authors.initials: KW
authors.lastname: Weitzel
authors.affiliation: Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.|Clinical & Translational Science Institute, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Amanda R
authors.initials: AR
authors.lastname: Elsey
authors.affiliation: Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.|Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Mosley
authors.affiliation: Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.|Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Donald M
authors.initials: DM
authors.lastname: Smith
authors.affiliation: Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.|Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, FL 32608, USA.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Staley
authors.affiliation: Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.|Department of Epidemiology, Colleges of Medicine & Public Health & Health Professions, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Almut G
authors.initials: AG
authors.lastname: Winterstein
authors.affiliation: Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Mathews
authors.affiliation: Department of Medicine, College of Medicine, University of Florida, Jacksonville, FL 32209, USA.
authors.forename: Francesco
authors.initials: F
authors.lastname: Franchi
authors.affiliation: Department of Medicine, College of Medicine, University of Florida, Jacksonville, FL 32209, USA.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Rollini
authors.affiliation: Department of Medicine, College of Medicine, University of Florida, Jacksonville, FL 32209, USA.
authors.forename: Dominick J
authors.initials: DJ
authors.lastname: Angiolillo
authors.affiliation: Department of Pathology, Immunology & Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Petr
authors.initials: P
authors.lastname: Starostik
authors.affiliation: Clinical & Translational Science Institute, University of Florida, Gainesville, FL 32610, USA.|Department of Pathology, Immunology & Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Clare-Salzler
authors.affiliation: Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.|Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Nelson
authors.affiliation: Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.|Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.|Clinical & Translational Science Institute, University of Florida, Gainesville, FL 32610, USA.|Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Johnson
mesh_terms: D005431:Florida; D005820:Genetic Testing / Q000379:methods* / Q000639:trends; D006266:Health Education / Q000379:methods* / Q000639:trends; D006801:Humans; D010597:Pharmacogenetics / Q000193:education* / Q000379:methods* / Q000639:trends; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D014495:Universities / Q000639:trends
keywords: PEG-interferon; clopidogrel; education; genotype; implementation; opioids; pharmacogenetics; proton pump inhibitors; selective serotonin uptake inhibitors; thiopurines