title: Novel immunotherapy and treatment modality for severe food allergies.
abstract: OBJECTIVE
  In recent years, many studies on oral immunotherapy (OIT) have been conducted; however, few have focused on severe food allergies. The purpose of this review was to assess the efficacy and safety of oral immunotherapies for patients with severe food allergy.
  
  
  RESULTS
  We reviewed multiple immunotherapy reports published within a few years or reports focusing on severe food allergies. We also investigated recent studies on OIT and novel food allergy management.
  
  
  CONCLUSIONS
  Immunotherapies targeting low-dose antigen exposure and oral food challenges using low-dose target volumes may be safer than conventional OIT. It is necessary to consider which immunotherapy regimen is appropriate based on allergy severity of the patient.
authors.affiliation: aSagamihara National Hospital, Sagamihara, Kanagawa bDepartment of Pediatrics, Jikei University School of Medicine, Tokyo cDepartment of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Nagakura
authors.forename: Sakura
authors.initials: S
authors.lastname: Sato
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yanagida
authors.forename: Motohiro
authors.initials: M
authors.lastname: Ebisawa
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000276:immunology / Q000627:therapeutic use*; D003888:Desensitization, Immunologic / Q000379:methods*; D018450:Disease Progression; D054796:Drug Dosage Calculations; D005512:Food Hypersensitivity / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance
chemical_list: D000485:Allergens