title: Expression of miRNA-21, miRNA-107, miRNA-137 and miRNA-29b in meningioma.
abstract: OBJECTIVE
  Meningiomas are among the most common intracranial tumors, accounting for 30% of all tumors of the central nervous system. Recent studies analyzing microRNA (miRNA) profiles and functions in cancer have provided valuable information about the molecular pathogenesis of several tumor types, including glioblastoma multiforme (GBM), hepatocellular carcinoma, and breast, lung, colon, and prostate cancer. miRNAs are a family of small, endogenous, noncoding RNAs of 18-25 nucleotides. In this study, we carried out a genome-wide array screen comparing miRNA-21, miRNA-107, miRNA-137 and miRNA-29b expression in meningiomas.
  
  
  METHODS
  A total of 50 meningioma patients (16 men and 34 women) aged between 32 and 80 years were included. The study was conducted at Istanbul Research and Training Hospital Neurosurgery Clinic.
  
  
  RESULTS
  Our results have shown a significant increase in miRNA-21 expression with increasing histopathologic grade, while there was a significant reduction in miRNA-107 expression with the increasing histopathological grade. miRNA-137 and miRNA-29b expression did not differ significantly according to histopathologic grade.
  
  
  CONCLUSIONS
  The subject of our study, i.e. the association between miRNA expression and meningioma, is continuously gaining more importance in the wider context of the recent developments in genetic treatments.
authors.affiliation: Istanbul Research and Training Hospital, Neurosurgery Clinic, Istanbul, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Katar
authors.affiliation: Istanbul Research and Training Hospital, Neurosurgery Clinic, Istanbul, Turkey. Electronic address: oguzbaran@gmail.com.
authors.forename: Oguz
authors.initials: O
authors.lastname: Baran
authors.affiliation: Bezmialem Vakif University, Department of Neurosurgery, Istanbul, Turkey.
authors.forename: Sevket
authors.initials: S
authors.lastname: Evran
authors.affiliation: Bezmialem Vakif University, Department of Neurosurgery, Istanbul, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Cevik
authors.affiliation: Bezmialem Vakif University, Department of Neurosurgery, Istanbul, Turkey.
authors.forename: Enes
authors.initials: E
authors.lastname: Akkaya
authors.affiliation: Sisli Hamidiye Etfal Research and Training Hospital, Neurology Clinic, Istanbul, Turkey.
authors.forename: Gozde
authors.initials: G
authors.lastname: Baran
authors.affiliation: Istanbul Research and Training Hospital, Neurosurgery Clinic, Istanbul, Turkey.
authors.forename: Veysel
authors.initials: V
authors.lastname: Antar
authors.affiliation: Florence Nightingale Hospital, Neurosurgery Clinic, Istanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Hanimoglu
authors.affiliation: Florence Nightingale Hospital, Neurosurgery Clinic, Istanbul, Turkey.
authors.forename: Mehmet Yasar
authors.initials: MY
authors.lastname: Kaynar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D012727:Sex Characteristics
chemical_list: C549045:MIRN107 microRNA, human; C524940:MIRN21 microRNA, human; D035683:MicroRNAs
keywords: Meningioma; miRNA-107; miRNA-137; miRNA-21; miRNA-29b