title: HIF has Biff - Crosstalk between HIF1a and the family of bHLH/PAS proteins.
abstract: Two decades of research into functions of the ubiquitous transcription factor HIF have revealed pervasive roles in development, oxygen homeostasis, metabolism, cancer and responses to ischemia. Unsurprisingly, HIF activities impinge on many pathologies, for which underlying molecular mechanisms are actively sought. HIF is a member of the heterodimeric bHLH/PAS family of transcription factors, a set of proteins that commonly function in developmental pathways and adaptive responses to environmental or physiological stress. Similarities in the mechanisms that regulate gene targeting by these transcription factors create opportunities for extensive crosstalk between family members. Data supporting pathway interactions between HIF1a and other bHLH/PAS factors, both collaborative and antagonistic, is beginning to surface in the areas of cancer, circadian rhythm, and immune responses. This review summarises the status of HIF1a-bHLH/PAS protein crosstalk and is dedicated to the memory of Lorenz Poellinger, a pioneer investigator into the molecular mechanisms of HIF, AHR, and ARNT bHLH/PAS factors.
authors.affiliation: Dept Molecular and Cellular Biology, University of Adelaide, 5005 South Australia, Australia.
authors.forename: Emily L
authors.initials: EL
authors.lastname: Button
authors.affiliation: Dept Molecular and Cellular Biology, University of Adelaide, 5005 South Australia, Australia.
authors.forename: David C
authors.initials: DC
authors.lastname: Bersten
authors.affiliation: Dept Molecular and Cellular Biology, University of Adelaide, 5005 South Australia, Australia. Electronic address: murray.whitelaw@adelaide.edu.au.
authors.forename: Murray L
authors.initials: ML
authors.lastname: Whitelaw
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D002468:Cell Physiological Phenomena / Q000502:physiology*; D018257:Helix-Loop-Helix Motifs / Q000502:physiology*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors
keywords: Basic helix loop helix Per Arnt Sim; Hypoxia inducible factor