title: Management of locally advanced primary mediastinal synovial sarcoma.
abstract: Primary mediastinal synovial sarcoma (PMSS) is a relatively rare disease, and patients are treated predominantly with surgery for resectable disease. Management of locally advanced borderline resectable and unresectable PMSS is not only challenging but also lacks standard guidelines. We present three patients with PMSS, who were unresectable or borderline resectable at presentation and were treated with neoadjuvant chemotherapy followed by surgery and postoperative radiotherapy.
authors.affiliation: Department of Surgical Oncology, Division of Thoracic Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
authors.forename: Ambarish S
authors.initials: AS
authors.lastname: Chatterjee
authors.affiliation: Department of Pathology, Division of Thoracic Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Kumar
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, Division of Thoracic Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
authors.forename: Nilendu
authors.initials: N
authors.lastname: Purandare
authors.affiliation: Department of Surgical Oncology, Division of Thoracic Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
authors.forename: Sabita
authors.initials: S
authors.lastname: Jiwnani
authors.affiliation: Department of Surgical Oncology, Division of Thoracic Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
authors.forename: George
authors.initials: G
authors.lastname: Karimundackal
authors.affiliation: Department of Surgical Oncology, Division of Thoracic Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.
authors.forename: C S
authors.initials: CS
authors.lastname: Pramesh
keywords: Locally advanced; R0-resection; neoadjuvant chemotherapy; primary mediastinal synovial sarcoma