title: Gelidium elegans Regulates the AMPK-PRDM16-UCP-1 Pathway and Has a Synergistic Effect with Orlistat on Obesity-Associated Features in Mice Fed a High-Fat Diet.
abstract: The incidence of obesity is rising at an alarming rate throughout the world and is becoming a major public health concern with incalculable social and economic costs.Gelidium elegans(GENS), also previously known asGelidium amansii, has been shown to exhibit anti-obesity effects. Nevertheless, the mechanism by which GENS is able to do this remains unclear. In the present study, our results showed that GENS prevents high-fat diet (HFD)-induced weight gain through modulation of the adenosine monophosphate-activated protein kinase (AMPK)-PR domain-containing16 (PRDM16)-uncoupling protein-1 (UCP-1) pathway in a mice model. We also found that GENS decreased hyperglycemia in mice that had been fed a HFD compared to corresponding controls. We also assessed the beneficial effect of the combined treatment with GENS and orlistat (a Food and Drug Administration-approved obesity drug) on obesity characteristics in HFD-fed mice. We found that in HFD-fed mice, the combination of GENS and orlistat is associated with more significant weight loss than orlistat treatment alone. Moreover, our results demonstrated a positive synergistic effect of GENS and orlistat on hyperglycemia and plasma triglyceride level in these animals. Thus, we suggest that a combination therapy of GENS and orlistat may positively influence obesity-related health outcomes in a diet-induced obese population.
authors.affiliation: Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Kyeonggi 463-400, Korea. wldk3176@gmail.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Choi
authors.affiliation: Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Kyeonggi 463-400, Korea. Kuijin.Kim@cha.ac.kr.
authors.forename: Kui-Jin
authors.initials: KJ
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Kyeonggi 463-400, Korea. kej763@naver.com.
authors.forename: Eun-Jeong
authors.initials: EJ
authors.lastname: Koh
authors.affiliation: Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Kyeonggi 463-400, Korea. bylee@cha.ac.kr.
authors.forename: Boo-Yong
authors.initials: BY
authors.lastname: Lee
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D050154:Adiposity / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009765:Obesity / Q000188:drug therapy*; D009929:Organ Size / Q000187:drug effects; D000077403:Orlistat; D010936:Plant Extracts / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D000071256:Uncoupling Protein 1 / Q000235:genetics / Q000378:metabolism*; D015430:Weight Gain
chemical_list: D019440:Anti-Obesity Agents; D001786:Blood Glucose; D004268:DNA-Binding Proteins; D007328:Insulin; D007783:Lactones; D010936:Plant Extracts; C521133:Prdm16 protein, mouse; D014157:Transcription Factors; C000604372:Ucp1 protein, mouse; D000071256:Uncoupling Protein 1; D000077403:Orlistat; D055372:AMP-Activated Protein Kinases
keywords: Gelidium amansii; Gelidium elegans; high-fat diet-induced obese mice; hyperglycemia; obesity