title: pH-responsive poly (acrylic acid)-gated mesoporous silica and its application in oral colon targeted drug delivery for doxorubicin.
abstract: Oral chemotherapy is the preferred route for cancer treatment because it can improve the efficacy and decrease the side effects. Unfortunately, most anticancer drugs suffered from their poor oral bioavailability. Herein, we construct a novel pH-triggered oral drug delivery system by capping of mesoporous silica SBA-15 with pH-responsive polymer poly (acrylic acid) (PAA) via a facile graft-onto strategy. The experiment results demonstrated that the PAA brushes were anchored on the pore outlets of mesoporous silica SBA-15, which can be acted as the gatekeeper to control the drug molecules transport in and out of the pore channels. The PAA capped mesoporous SBA-15 (PAA/SBA-15) exhibited a high drug loading capacity (785.7mg/g), excellent pH-sensitivity and good biocompatibility. In gastric environment (pH=2.0), the drug doxorubicin (DOX) molecules were encapsulated in the pore channels because the pore outlets were capped with collapsed PAA. In contrast, in colonic environment (pH=7.6), it exhibited a fast release because of the removal of capping. In addition, the water solubility of DOX in colonic environment was enhanced after DOX being loaded into the pores of PAA/SBA-15. This pH-triggered oral drug delivery system has promising applications for treatment of colon cancer and other colon diseases.
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou, 466001, PR China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou, 466001, PR China.
authors.forename: Boshi
authors.initials: B
authors.lastname: Tian
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou, 466001, PR China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou, 466001, PR China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, 510055, PR China.
authors.forename: Shuyi
authors.initials: S
authors.lastname: Wu
authors.affiliation: University Research Facility in Materials Characterization and Device Fabrication, The Hong Kong Polytechnic University, Hong Kong, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou, 466001, PR China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou, 466001, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou, 466001, PR China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou, 466001, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jin
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou, 466001, PR China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou, 466001, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou, 466001, PR China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou, 466001, PR China.
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.affiliation: The Key Laboratory of Rare Earth Functional Materials and Applications, Zhoukou Normal University, Zhoukou, 466001, PR China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou, 466001, PR China. Electronic address: zlwang2007@hotmail.com.
authors.forename: Zhenling
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Chemistry, South University of Science and Technology of China, Shenzhen, PR China. Electronic address: quanzw@sustc.edu.cn.
authors.forename: Zewei
authors.initials: Z
authors.lastname: Quan
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000284:Administration, Oral; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism*; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D059630:Mesenchymal Stem Cells; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; C509969:SBA-15; C006903:carbopol 940; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: Drug delivery; Gatekeeper; Mesoporous silica; Targeted release; pH-responsive