title: The role of STIM1 and SOCE in smooth muscle contractility.
abstract: Contraction is a central feature for skeletal, cardiac and smooth muscle; this unique feature is largely dependent on calcium (Ca2+) signaling and therefore maintenance of internal Ca2+stores. Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane protein that functions as a Ca2+sensor for the activation store-operated calcium channels (SOCCs) on the plasma membrane in response to depleted internal sarco(endo)plasmic (S/ER) reticulum Ca2+stores. STIM1 was initially characterized in non-excitable cells; however, evidence from both animal models and human mutations suggests a role for STIM1 in modulating Ca2+homeostasis in excitable tissues as well. STIM1-dependent SOCE is particularly important in tissues undergoing sustained contraction, leading us to believe STIM1 may play a role in smooth muscle contraction. To date, the role of STIM1 in smooth muscle is unknown. In this review, we provide a brief overview of the role of STIM1-dependent SOCE in striated muscle and build off that knowledge to investigate whether STIM1 contributes to smooth muscle contractility. We conclude by discussing the translational implications of targeting STIM1 in the treatment of smooth muscle disorders.
authors.affiliation: Duke University School of Medicine, Durham, NC, 27704, United States; Howard Hughes Medical Research Fellowship Program, Chevy Chase, MD, 20815, United States.
authors.forename: C H
authors.initials: CH
authors.lastname: Feldman
authors.affiliation: Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, 27704, United States.
authors.forename: C A
authors.initials: CA
authors.lastname: Grotegut
authors.affiliation: Department of Medicine, Duke University School of Medicine, Durham, NC, 27704, United States. Electronic address: rosen029@mc.duke.edu.
authors.forename: P B
authors.initials: PB
authors.lastname: Rosenberg
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000166:cytology / Q000502:physiology*; D000071737:Stromal Interaction Molecule 1 / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D000071737:Stromal Interaction Molecule 1
keywords: Smooth muscle contraction; Store-operated calcium channels; Store-operated calcium entry; Stromal interaction molecule 1 (STIM1)