title: Sedation in oral and maxillofacial day care surgery: A comparative study between intravenous dexmedetomidine and midazolam.
abstract: BACKGROUND
  Sedation is an important component of day care oral and maxillofacial surgical procedures under local anesthesia. Although various sedative drugs in different regimens have been used for sedation, an ideal agent and regimen are yet to be established.
  
  
  OBJECTIVE
  The aim of this study is to compare the efficacy of intravenous (IV) dexmedetomidine and midazolam as a sedative agent for day care oral and maxillofacial surgical procedures.
  
  
  METHODS
  The study was conducted in the Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India.
  
  
  METHODS
  A total of sixty adult patients of age group 18-65 years, of either sex were randomly selected equally in two groups for the study. One group named Group D received dexmedetomidine and the other named Group M received midazolam. Patients were evaluated for oxygen saturation (SPO2), respiration rate (RR), systolic blood pressure (SBP), diastolic blood pressure (DBP), Ramsay sedation score, bispectral index (BIS) score, amnesia, Aldrete score, relaxation during the surgery, and drug preference.
  
  
  RESULTS
  Midazolam was associated with greater amnesia. Dexmedetomidine was associated with lower heart rate, SBP, and DBP. There was no significant difference in SPO2, RR, Aldrete score, Ramsay sedation score, and BIS score between the two drugs. Patient preference and relaxation were more in dexmedetomidine group.
  
  
  CONCLUSIONS
  IV dexmedetomidine is a comparable alternative to midazolam for sedation in day care oral and maxillofacial surgery under local anesthesia. It is the preferred drug when a lower heart rate and blood pressure or less amnesia is needed without any serious side effects.
authors.affiliation: Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Mishra
authors.affiliation: Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India.
authors.forename: Krishna Gopal
authors.initials: KG
authors.lastname: Birmiwal
authors.affiliation: Department of Anaesthesiology and Critical Care, SCB Medical College and Hospital, Cuttack, Odisha, India.
authors.forename: Nibedita
authors.initials: N
authors.lastname: Pani
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India.
authors.forename: Subhrajit
authors.initials: S
authors.lastname: Raut
authors.affiliation: Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Department of Dentistry, City Hospital, Ganjam, Odisha, India.
authors.forename: Krushna Chandra
authors.initials: KC
authors.lastname: Rath
keywords: Aldrete score; Ramsay sedation score; bispectral index