title: Resilience and Vulnerability to Pain and Inflammation in the Hippocampus.
abstract: Increasing evidence demonstrates the importance of hippocampal neurogenesis, a fundamental mechanism of neuroplasticity associated with cognition and emotion, in correlation to neurodegenerative and psychiatric disorders. Neuropsychiatric disorders are often a result of chronic stress or pain followed by inflammation; all these conditions manifest cognitive deficits and impairments in neurogenesis. However, while some individuals are more susceptible to stress, others are able to adapt to new environments via mechanisms of resilience. In light of this emerging field and based on extensive research, the role of neurogenesis is summarized and presented as a potentially powerful therapeutic tool.
authors.affiliation: Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), Johannes Gutenberg University, School of Medicine, Mainz 55131, Germany. verica.vasic@unimedizin-mainz.de.
authors.forename: Verica
authors.initials: V
authors.lastname: Vasic
authors.affiliation: Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), Johannes Gutenberg University, School of Medicine, Mainz 55131, Germany. mirko.schmidt@unimedizin-mainz.de.
authors.forename: Mirko H H
authors.initials: MHH
authors.lastname: Schmidt
mesh_terms: D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000503:physiopathology; D004644:Emotions / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008959:Models, Neurological; D055495:Neurogenesis; D010146:Pain / Q000503:physiopathology*
keywords: inflammation; neurogenesis; neuropsychiatric disorders; pain; resilience