title: Antibody Response to Live Attenuated Vaccines in Adults in Japan.
abstract: The purpose of this study was to examine the efficacy rendered with a single dose of live attenuated measles, rubella, mumps, and varicella containing vaccine. We inoculated healthcare workers (HCWs) with a single dose of vaccine to a disease lacking in antibody titer for those not meeting the criteria of our hospital (measles: <16.0 (IgG enzyme immunoassay (EIA)), rubella: ≤1:32 (hemagglutination-inhibition), mumps: <4.0 (IgG EIA), and varicella: <4.0 (IgG EIA)). At 28-60 days after vaccination, the antibody titer was tested again. We included 48 HCWs. A total of 32, 15, 31, and 10 individuals were inoculated with a single dose of measles-containing, rubella-containing, mumps, or varicella vaccine, respectively, and showed significant antibody elevation (9.2 ± 12.3 to 27.6 ± 215.6, p<0.001; 8 ± 1.2 to 32 ± 65.5, p<0.001; 3.0 ± 1.0 to 13.1 ± 8.6, p<0.05; and 2.6 ± 1.3 to 11.8 ± 8.1, p<0.001, respectively). Major side effects were not observed. In a limited population, a single dose of live attenuated vaccine showed elevation of antibody titer without any severe adverse reactions. However, whether the post-vaccination response rate criteria of our university was fulfilled could not be determined owing to limited sample size.
authors.affiliation: Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522 Japan . Tel: +81-744-22-3051 (ext. 3525).
authors.forename: Taku
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: Center for Infectious Diseases, Nara Medical University, Nara Japan.
authors.forename: Fukumi
authors.initials: F
authors.lastname: Uchiyama-Nakamura
authors.affiliation: Center for Infectious Diseases, Nara Medical University, Nara Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Sugata-Tsubaki
authors.affiliation: Center for Infectious Diseases, Nara Medical University, Nara Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: Center for Infectious Diseases, Nara Medical University, Nara Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Uno
authors.affiliation: Center for Infectious Diseases, Nara Medical University, Nara Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Kasahara
authors.affiliation: Center for Infectious Diseases, Nara Medical University, Nara Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Health Management Center, Nara Medical University, Nara Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Konishi
authors.affiliation: Center for Infectious Diseases, Nara Medical University, Nara Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mikasa
keywords: Antibody titer; Measles; Mumps; Occupational health; Rubella; Vaccination; Varicella