title: Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats.
abstract: Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation, and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (52 kcal% fat) and 20% fructose drinking water were divided into 4 groups and treated with the dietary replacement of 0%, 10%, 15%, or 20% of lard with shrimp oil for 10 weeks. Age-matched rats fed a low-fat diet (10 kcal% fat) were used as the normal control. Rats on the high-fat diet showed impaired (p < 0.05) glucose tolerance and insulin resistance compared with rats fed the low-fat diet. Shrimp oil improved (p < 0.05) oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index; decreased serum insulin, leptin, hemoglobin A1c, and free fatty acids; and increased adiponectin. Shrimp oil also increased (p < 0.05) antioxidant capacity and reduced oxidative stress and chronic inflammation. The results demonstrated that shrimp oil dose-dependently improved glycemic control in obese rats through multiple mechanisms.
authors.affiliation: a Coastal Zones Research Institute Inc. (CZRI), Shippagan, NB E8S 1J2, Canada.|b Natural Health Products Program, Aquatic and Crop Resource Development, National Research Council of Canada, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Nair
authors.affiliation: a Coastal Zones Research Institute Inc. (CZRI), Shippagan, NB E8S 1J2, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Gagnon
authors.affiliation: a Coastal Zones Research Institute Inc. (CZRI), Shippagan, NB E8S 1J2, Canada.
authors.forename: Claude
authors.initials: C
authors.lastname: Pelletier
authors.affiliation: a Coastal Zones Research Institute Inc. (CZRI), Shippagan, NB E8S 1J2, Canada.
authors.forename: Nadia
authors.initials: N
authors.lastname: Tchoukanova
authors.affiliation: c Natural Health Products Program, Aquatic and Crop Resource Development, National Research Council of Canada, 1411 Oxford Street, Halifax, NS B3H 3Y8, Canada.
authors.forename: Junzeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: d Novaceutics Consulting, 6501 Oak St, Halifax, NS B3L 1H5, Canada.
authors.forename: H Stephen
authors.initials: HS
authors.lastname: Ewart
authors.affiliation: e Department of Biochemistry and Molecular Biology, Dalhousie University, 5850 College Street, Halifax, NS B3H 4R2, Canada.
authors.forename: K Vanya
authors.initials: KV
authors.lastname: Ewart
authors.affiliation: a Coastal Zones Research Institute Inc. (CZRI), Shippagan, NB E8S 1J2, Canada.|c Natural Health Products Program, Aquatic and Crop Resource Development, National Research Council of Canada, 1411 Oxford Street, Halifax, NS B3H 3Y8, Canada.
authors.forename: Guangling
authors.initials: G
authors.lastname: Jiao
authors.affiliation: b Natural Health Products Program, Aquatic and Crop Resource Development, National Research Council of Canada, 550 University Avenue, Charlottetown, PE C1A 4P3, Canada.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Wang
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D033202:Anostraca; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D018149:Glucose Intolerance / Q000178:diet therapy; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000178:diet therapy*; D009821:Oils / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D012758:Shellfish; D014801:Vitamin A / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage; D024341:Xanthophylls / Q000008:administration & dosage
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D006442:Glycated Hemoglobin; D007328:Insulin; D020738:Leptin; D009821:Oils; D014801:Vitamin A; D014810:Vitamin E; D024341:Xanthophylls; C005948:astaxanthine
keywords: diet-induced obesity; glucose tolerance; inflammation; insulin sensitivity; obésité d’origine alimentaire; oxidative stress; rat; sensibilité insulinique; stress oxydatif; tolérance au glucose