title: Outcome of isolated enlarged cisterna magna identified in utero: experience at a single medical center in mainland China.
abstract: OBJECTIVE
  The objective of this study is to explore the effects of prenatal isolated enlarged cisterna magna (IECM) on postnatal development.
  
  
  METHODS
  We followed up 123 fetuses with an enlarged cisterna magna (ECM), who were divided into IECM (group 1) and non-IECM (ECM plus other anomalies, group 2) groups, and compared 60 normal infants with normal fetal ultrasound. We assessed infants postnatally using the Gesell Developmental Schedules. Fetal magnetic resonance imaging, karyotyping, and chromosomal microarray analysis test were offered.
  
  
  RESULTS
  The developmental quotients of gross motor and adapting abilities were significantly lower in infants with IECM compared with normal infants (80.81 ± 3.44 vs 99.20 ± 4.54 and 98.70 ± 3.27 vs 100.30 ± 5.33, respectively), and the depths ≥15 mm and 13 to 14.90 mm were associated with significantly lower adapting abilities (P < 0.03 and P < 0.05) compared with the normal (97.16 ± 2.17 and 98.21 ± 1.76 vs 100.30 ± 5.33, respectively), while these scores were still within the borderline range, and the other subtests were not significantly different. Furthermore, the group 2 showed a significantly worse performance in the test.
  
  
  CONCLUSIONS
  The outcome of children with IECM may be guarded, especially some subtle deficits in adapting and gross motor abilities. In contrast, the developmental quotients of infants with prenatal non-IECM were lower than that those of normal infants. © 2017 John Wiley & Sons, Ltd.
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.|Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Zequn
authors.identifier: http://orcid.org/0000-0003-1329-0564
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Fu
authors.affiliation: Department of Obstetrics, Foshan Women and Children Hospital, Foshan, Guangdong, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Min
authors.initials: M
authors.lastname: Pan
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhen
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Dongzhi
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
authors.forename: Can
authors.initials: C
authors.lastname: Liao
mesh_terms: D000328:Adult; D002657:Child Development; D002675:Child, Preschool; D002946:Cisterna Magna / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D055815:Young Adult