title: Exploiting non-covalent π interactions for catalyst design.
abstract: Molecular recognition, binding and catalysis are often mediated by non-covalent interactions involving aromatic functional groups. Although the relative complexity of these so-called π interactions has made them challenging to study, theory and modelling have now reached the stage at which we can explain their physical origins and obtain reliable insight into their effects on molecular binding and chemical transformations. This offers opportunities for the rational manipulation of these complex non-covalent interactions and their direct incorporation into the design of small-molecule catalysts and enzymes.
authors.affiliation: Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.|Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Neel
authors.affiliation: Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Hilton
authors.affiliation: Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Sigman
authors.affiliation: Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.|Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste
mesh_terms: D000838:Anions / Q000737:chemistry; D002384:Catalysis / Q000187:drug effects; D002412:Cations / Q000737:chemistry; D015195:Drug Design; D004798:Enzymes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D008956:Models, Chemical; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000838:Anions; D002412:Cations; D004798:Enzymes; D054852:Small Molecule Libraries