title: Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery.
abstract: An unnatural CDP-amino acid (kd) is used in the design and synthesis of novel cell penetrating peptidomimetic (Kkd-5). The balanced cationic nature and structural rigidity of Kkd-5 resulted in serum stability, non-toxicity to cells, and interaction with membrane and DNA, all of which facilitated efficient cellular uptake and DNA delivery.
authors.affiliation: Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bengaluru, Karnataka 560064, India. tgraju@jncasr.ac.in.
authors.forename: Chilakapati
authors.initials: C
authors.lastname: Madhu
authors.forename: Chandrashekhar
authors.initials: C
authors.lastname: Voshavar
authors.forename: K
authors.initials: K
authors.lastname: Rajasekhar
authors.forename: Thimmaiah
authors.initials: T
authors.lastname: Govindaraju
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004151:Dipeptides / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D004355:Drug Stability; D006367:HeLa Cells; D006801:Humans; D057786:Peptidomimetics / Q000737:chemistry* / Q000378:metabolism
chemical_list: D057846:Cell-Penetrating Peptides; D004151:Dipeptides; D004337:Drug Carriers; D057786:Peptidomimetics; D004247:DNA