title: Impact of bone marrow-derived mesenchymal stem cells on remodeling the lung injury induced by lipopolysaccharides in mice.
abstract: OBJECTIVE
  This study evaluated the potential of bone marrow derived mesenchymal stem cells (MSCs) to regulate cytokines and remodel the lung induced by lipopolysaccharide (LPS; O-antigen).
  
  
  METHODS
  A group of mice (n = 21) was inoculated intraperitoneally with one dose 0.1 ml containing 0.025 mg LPS/mouse, and another treated intravenously with one dose of labeling bone marrow derived MSCs at 7.5 × 105cell/mouse 4 h after LPS injection. All animals were sacrificed on the 1st, 7th and 14th days post-injection.
  
  
  RESULTS
  MSCs increased the level of IL-10 with suppression of TNF-α, decrease of collagen fibers and renewal of alveolar type I cells, together with lung tissue remodeling.
  
  
  CONCLUSIONS
  MSCs were shown to modulate inflammatory cytokines (TNF-α and IL-10) and to differentiate into alveolar type I cells, which prevented fibrosis in lung tissue from LPS-treated mice.
authors.affiliation: Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
authors.forename: Mouchira M
authors.initials: MM
authors.lastname: Mohi El-Din
authors.affiliation: Biochemistry & Molecular Biology Department, Medicine Faculty, Cairo University, Cairo, Egypt; Biochemistry & Molecular Biology Department, Medicine Faculty, Cairo University, Cairo, Egypt.
authors.forename: Laila A
authors.initials: LA
authors.lastname: Rashed
authors.affiliation: Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
authors.forename: Mohi A
authors.initials: MA
authors.lastname: Mahmoud Haridy
authors.affiliation: Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
authors.forename: Atef Mohamed
authors.initials: AM
authors.lastname: Khalil
authors.affiliation: Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Mohamed Albadry
keywords: cytokines; flow cytometry; fluorescent technique; histopathology; immunohistochemistry; lipolysaccharide; lungs; mesenchymal stem cells; mice