title: How do messenger RNA splicing alterations drive myelodysplasia?
abstract: Mutations in RNA splicing factors are the single most common class of genetic alterations in myelodysplastic syndrome (MDS) patients. Although much has been learned about how these mutations affect splicing at a global- and transcript-specific level, critical questions about the role of these mutations in MDS development and maintenance remain. Here we present the questions to be addressed in order to understand the unique enrichment of these mutations in MDS.
authors.affiliation: Section of Hematology, Yale Comprehensive Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT; and.
authors.forename: Poorval
authors.identifier: 0000-0001-7886-9994
authors.initials: P
authors.lastname: Joshi
authors.affiliation: Section of Hematology, Yale Comprehensive Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT; and.
authors.forename: Stephanie
authors.identifier: 0000-0002-2737-9810
authors.initials: S
authors.lastname: Halene
authors.affiliation: Human Oncology and Pathogenesis Program and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
authors.forename: Omar
authors.identifier: 0000-0002-3907-6171
authors.initials: O
authors.lastname: Abdel-Wahab
mesh_terms: D044127:Epigenesis, Genetic; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D012326:RNA Splicing; D000072260:RNA Splicing Factors / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D010750:Phosphoproteins; D000072260:RNA Splicing Factors; D012333:RNA, Messenger; C112491:SF3B1 protein, human