title: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis.
abstract: Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options. Both randomized and non-randomized studies were summarized with the emphasis focused on overall survival. In summary, CRS and HIPEC are indeed a promising treatment option for gastric cancer with peritoneal carcinomatosis and large randomized clinical trials are warranted.
authors.affiliation: Bon Secours Cancer Institute, Bon Secours Health System, Richmond, VA 23226, USA.
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Ellison
authors.affiliation: Bon Secours Cancer Institute, Bon Secours Health System, Richmond, VA 23226, USA.
authors.forename: Yangao
authors.initials: Y
authors.lastname: Man
authors.affiliation: Bon Secours Cancer Institute, Bon Secours Health System, Richmond, VA 23226, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Stojadinovic
authors.affiliation: Laboratory of Oncology, the First People's Hospital of Jingzhou City, the First Hospital and Clinical Medical School of Yangtze University, Jingzhou 434008, China; Laboratory of Oncology, Center for Molecular Medicine, Medical School, Yangtze University, Jingzhou 434023, China.
authors.forename: Hongwu
authors.initials: H
authors.lastname: Xin
authors.affiliation: Bon Secours Cancer Institute, Bon Secours Health System, Richmond, VA 23226, USA.
authors.forename: Itzhak
authors.initials: I
authors.lastname: Avital
keywords: Cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis