title: Oleuropein improves glucose tolerance and lipid profile in rats with simultaneous renovascular hypertension and type 2 diabetes.
abstract: Oleuropein mediates most of the beneficial effects of olive products. This study examined the role of oxidative stress in the effects of oleuropein on lipid profile and blood glucose in rats with simultaneous renovascular hypertension and type 2 diabetes. Eight groups (n = 7-9 each) of male Sprague-Dawley rats including a control, a type 2 diabetic, a renovascular hypertensive, a sham, a simultaneously hypertensive diabetic receiving vehicle, and 3 simultaneously hypertensive-diabetic receiving 20, 40, or 60 mg/kg/day oleuropein were used. Four weeks after treatment, blood glucose, lipid profile, and biomarkers of oxidative stress were measured, and glucose tolerance test (GTT) was performed. Simultaneously hypertensive diabetic rats had significantly higher blood pressure, blood glucose, and serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride and malondialdehyde. They also had lower serum high-density lipoprotein cholesterol, erythrocyte superoxide dismutase, and impaired glucose tolerance. Oleuropein significantly reduced blood pressure, blood glucose, and serum total cholesterol, LDL-C, triglyceride and malondoaldehyde. It also increased serum high-density lipoprotein cholesterol, erythrocyte superoxide dismutase, and improved glucose tolerance. The findings show that the model is associated with impaired glucose tolerance, and adverse lipid profile. They also show that oleuropein, partly by an antioxidant mechanism, improves glucose tolerance and changed lipid profile favorably.
authors.affiliation: a Department of Physiology and Pharmacology, School of Medicine , Alborz University of Medical Sciences , Karaj 3146883811 , Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Khalili
authors.affiliation: b Cardiovascular Pharmacology, Research Lab, Department of Pharmacology, School of Medicine , Shiraz University of Medical Sciences , Shiraz 7134845794 , Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Nekooeian
authors.affiliation: c Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences , Shiraz University of Medical Sciences , Shiraz 7134845794 , Iran.
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Khosravi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006977:Hypertension, Renal / Q000188:drug therapy*; D006978:Hypertension, Renovascular; D057888:Iridoid Glucosides; D039823:Iridoids / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000494:pharmacology; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D057888:Iridoid Glucosides; D039823:Iridoids; D008055:Lipids; C002769:oleuropein; D008315:Malondialdehyde; D013311:Streptozocin; D013482:Superoxide Dismutase
keywords: Oleuropein; antioxidant; diabetes; lipid profile; renal hypertension