title: Importance of amygdala noradrenergic activity and large-scale neural networks in regulating emotional arousal effects on perception and memory.
abstract: Mather and colleagues postulate that norepinephrine promotes selective processing of emotionally salient information through local "hotspots" where norepinephrine release interacts with glutamatergic activity. However, findings in rodents and humans indicate that norepinephrine is ineffective in modulating mnemonic processes in the absence of a functional amygdala. We therefore argue that emphasis should shift toward modulatory effects of amygdala-driven changes at the network level.
authors.affiliation: Department of Cognitive Neuroscience,Radboud University Medical Center,6500 HB Nijmegen,The Netherlandsbenno.roozendaal@radboudumc.nl.
authors.forename: Benno
authors.initials: B
authors.lastname: Roozendaal
authors.affiliation: Department of Cognitive Neuroscience,Radboud University Medical Center,6500 HB Nijmegen,The Netherlandsbenno.roozendaal@radboudumc.nl.
authors.forename: Laura
authors.initials: L
authors.lastname: Luyten
authors.affiliation: Department of Cognitive Neuroscience,Radboud University Medical Center,6500 HB Nijmegen,The Netherlandsbenno.roozendaal@radboudumc.nl.
authors.forename: Lycia D
authors.initials: LD
authors.lastname: de Voogd
authors.affiliation: Department of Cognitive Neuroscience,Radboud University Medical Center,6500 HB Nijmegen,The Netherlandsbenno.roozendaal@radboudumc.nl.
authors.forename: Erno J
authors.initials: EJ
authors.lastname: Hermans
mesh_terms: D000679:Amygdala / Q000502:physiology*; D001143:Arousal; D004644:Emotions; D006801:Humans; D008568:Memory; D009638:Norepinephrine / Q000502:physiology
chemical_list: D009638:Norepinephrine