title: Insights Into the Role of Collagen in Vocal Fold Health and Disease.
abstract: As one of the key fibrous proteins in the extracellular matrix, collagen plays a significant role in the structural and biomechanical characteristics of the vocal fold. Anchored fibrils of collagen create secure structural regions within the vocal folds and are strong enough to sustain vibratory impact and stretch during phonation. This contributes tensile strength, density, and organization to the vocal folds and influences health and pathogenesis. This review offers a comprehensive summary for a current understanding of collagen within normal vocal fold tissues throughout the life span as well as vocal pathology and wound repair. Further, collagen's molecular structure and biosynthesis are discussed. Finally, collagen alterations in tissue injury and repair and the incorporation of collagen-based biomaterials as a method of treating voice disorders are reviewed.
authors.affiliation: Department of Communication Sciences and Disorders, Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of Wisconsin-Madison, Madison, Wisconsin.
authors.forename: Sharon S
authors.initials: SS
authors.lastname: Tang
authors.affiliation: Department of Communication Sciences and Disorders, Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of Wisconsin-Madison, Madison, Wisconsin.
authors.forename: Vidisha
authors.initials: V
authors.lastname: Mohad
authors.affiliation: Department of Surgery, Division of Otolaryngology-Head & Neck Surgery, University of Wisconsin-Madison, Madison, Wisconsin.
authors.forename: Madhu
authors.initials: M
authors.lastname: Gowda
authors.affiliation: Department of Surgery, Voice and Swallow Clinics, Division of Otolaryngology-Head & Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address: thibeault@surgery.wisc.edu.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Thibeault
mesh_terms: D000367:Age Factors; D000375:Aging / Q000378:metabolism / Q000473:pathology; D001696:Biomechanical Phenomena; D003094:Collagen / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010699:Phonation; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013718:Tensile Strength; D014732:Vibration; D014827:Vocal Cords / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D014832:Voice Disorders / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D014833:Voice Quality; D014945:Wound Healing
chemical_list: D003094:Collagen
keywords: Biomaterial; Biomechanics; Collagen; Vocal fold; Wound healing