title: The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application.
abstract: MicroRNAs (miRNAs) are a class of small single-stranded and highly conserved non-coding RNAs, which are closely linked to cardiac disorders such as myocardial infarction (MI), cardiomyocyte hypertrophy, and heart failure. A growing number of studies have demonstrated that miRNAs determine the fate of the heart by regulating cardiac cell death and regeneration after MI. A deep understanding of the pathophysiology of miRNA dependent regulatory pathways in these processes is required. The role of miRNAs as diagnostic, prognostic, and therapeutic targets also needs to be explored in order to utilize them in clinical settings. This review summarizes the role of miRNAs in myocardial infarction and focuses mainly on their influence on cardiomyocyte regeneration and cell death including apoptosis, necrosis, and autophagy. In addition, the targets of pro- and anti-MI miRNAs are comparatively described. In particular, the possibilities of miRNA-based diagnostic and therapeutic strategies for myocardial infarction are discussed in this review.
authors.affiliation: Institute for Translational Medicine, Qingdao University, Qingdao 266021, China. tengsun@qdu.edu.cn.
authors.forename: Teng
authors.initials: T
authors.lastname: Sun
authors.affiliation: Institute for Translational Medicine, Qingdao University, Qingdao 266021, China. dongyanhande@163.com.
authors.forename: Yan-Han
authors.initials: YH
authors.lastname: Dong
authors.affiliation: Institute for Translational Medicine, Qingdao University, Qingdao 266021, China. mtdw2015@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.affiliation: Institute for Translational Medicine, Qingdao University, Qingdao 266021, China. schy1116@163.com.
authors.forename: Chun-Ying
authors.initials: CY
authors.lastname: Shi
authors.affiliation: Institute for Translational Medicine, Qingdao University, Qingdao 266021, China. wangk696@163.com.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Institute for Translational Medicine, Qingdao University, Qingdao 266021, China. akram@soe.ucsc.edu.
authors.forename: Muhammad-Akram
authors.initials: MA
authors.lastname: Tariq
authors.affiliation: Institute for Translational Medicine, Qingdao University, Qingdao 266021, China. wangjx@qdu.edu.cn.
authors.forename: Jian-Xun
authors.initials: JX
authors.lastname: Wang
authors.affiliation: Institute for Translational Medicine, Qingdao University, Qingdao 266021, China. peifli@qdu.edu.cn.
authors.forename: Pei-Feng
authors.initials: PF
authors.lastname: Li
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008955:Models, Cardiovascular; D008957:Models, Genetic; D009203:Myocardial Infarction / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D057170:Translational Research, Biomedical / Q000379:methods / Q000639:trends
chemical_list: D035683:MicroRNAs
keywords: cardiomyocyte regeneration; clinical application; microRNAs; myocardial cell death; myocardial infarction