title: XEN Glaucoma Implant with Mitomycin C 1-Year Follow-Up: Result and Complications.
abstract: Purpose. To evaluate gel microstent (XEN, Aquesys, Inc) for treatment of primary open angle glaucoma (POAG).Methods. In this prospective interventional study, 13 eyes with POAG underwent XEN implantation with subconjunctival mitomycin-C. Of those eyes, 3 were pseudophakic and 10 underwent simultaneous phacoemulsification and XEN. Patients had uncontrolled IOP, had intolerance to therapy, or had maximal therapy but undergoing cataract extraction. Follow-up visits included IOP, number of medications, vision, and complications and lasted for 1 year. Complete success was defined as IOP reduction ≥20% from preoperative baseline at 1 year without any glaucoma medications while partial success as IOP reduction of ≥20% at 1 year with medications.Results. IOP dropped from 16 ± 4 mmHg pre-op to 9 ± 5, 11 ± 6, 12 ± 5, 12 ± 4, and 12 ± 3 mmHg at 1 week, 1, 3, 6, and 12 months (p= 0.004, 0.026, 0.034, 0.01, and 0.01, Wilcoxon Signed Ranks) consecutively. BCVA (LogMAR) was 0.33 ± 0.34 and improved to 0.13 ± 0.11 at 1 year. Mean number of medications dropped from 1.9 ± 1 preoperatively to 0.3 ± 0.49 (p= 0.003) at 1 year. 42% of eyes achieved complete success and 66% qualified success. Complications included choroidal detachment in 2 eyes, and implant extrusion in 1 eye, and 2 eyes underwent trabeculectomy.Conclusion. XEN implant is an effective surgical treatment for POAG, with significant reduction in IOP and glaucoma medications at 1 year follow-up.
authors.affiliation: Alpha Vision Augenzentrum, Bremerhaven, Germany; Research Institute of Ophthalmology, Cairo, Egypt.
authors.forename: Ahmed
authors.identifier: 0000-0002-9743-4109
authors.initials: A
authors.lastname: Galal
authors.affiliation: Alpha Vision Augenzentrum, Bremerhaven, Germany.
authors.forename: Alper
authors.initials: A
authors.lastname: Bilgic
authors.affiliation: Ophthalmology Department, Cairo University, Cairo, Egypt.
authors.forename: Rasha
authors.initials: R
authors.lastname: Eltanamly
authors.affiliation: Ophthalmology Department, Cairo University, Cairo, Egypt.
authors.forename: Amr
authors.identifier: 0000-0002-2828-3992
authors.initials: A
authors.lastname: Osman