title: Asymmetric Cascade Assembly of 1,2-Diaza-1,3-dienes and α,β-Unsaturated Aldehydes via Dienamine Activation.
abstract: A cascade vinylogous 1,6-Michael addition/1,4-proton shift/aza-Michael addition/hemiaminal formation sequence of 1,2-diaza-1,3-dienes and β-substituted 2-butenals has been developed under the influence of dienamine activation of a chiral secondary amine. This method exhibits high regio- and chemoselectivity and provides an efficient and straightforward approach to bicyclic l,8-diazabicyclo[3.3.0]octane skeletons with a tetrasubstituted stereogenic center with fair to excellent enantioselectivity.
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Ran
authors.affiliation: Ruian City People's Hospital , Ruian 325200, Zhejiang Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Gong
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Jing-Fei
authors.initials: JF
authors.lastname: Yue
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Xing-Xing
authors.initials: XX
authors.lastname: Yang
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Su-Lan
authors.initials: SL
authors.lastname: Zhou
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.affiliation: Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041, China.
authors.forename: Ying-Chun
authors.identifier: 0000-0003-1902-0979
authors.initials: YC
authors.lastname: Chen