title: A novel process for preparation of fatty acid oil mixture in solid form.
abstract: The present study describes a novel and scalable process for preparation of omega-3 and omega-6 fatty acids in solid form. The process involves multiple steps consisting of combining the oil with a metal base in alcohol to form a solution, followed by addition of reaction mixture to acetonitrile (anti-solvent) to form a slurry and further separating the solid through filtration. This process results in formation of a flowable solid with yield of 44-76% depending on the procedure employed. The fatty acid profile of the calcium and magnesium salts was stable after one year of storage in ambient conditions. The type of solvent and anti-solvent employed in such process has tremendous effect on the resulting solid texture, which could range from complete gum to a workable, filterable solid. It was also demonstrated that increasing the concentration of base in alcohol reduces the amount of residual acetonitrile in the solid.
authors.affiliation: Biorefining and Remediation Laboratory, Department of Process Engineering and Applied Science, Dalhousie University, 1360 Barrington Street, Halifax, Nova Scotia B3J 1Z1, Canada. Electronic address: azadeh.kermanshahipour@dal.ca.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Kermanshahi Pour
authors.affiliation: Solid State Pharma, 1344 Summer St., Halifax, NS B3H 0A8, Canada.
authors.forename: Lauren
authors.initials: L
authors.lastname: MacEachern
authors.affiliation: Solid State Pharma, 1344 Summer St., Halifax, NS B3H 0A8, Canada.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mirmehrabi
mesh_terms: D015525:Fatty Acids, Omega-3 / Q000737:chemistry*; D043371:Fatty Acids, Omega-6 / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated
keywords: Omega-3; Polyunsaturated fatty acids; Powder; Process; Solid form; Stability