title: Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences
abstract: Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect
  of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate
  adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements
  have been investigated for this purpose in recent years and a variety of positive and negative results have been yielded.
  However, no definitive supplement has so far been proposed to prevent CDDP-induced nephrotoxicity; however, this
  condition is gender related and the sex hormone estrogen may protect the kidney against CDDP damage. In this review,
  the results of research related to the effect of different synthetic and herbal antioxidants supplements are presented and
  discussed with suggestions included for future work.
authors.affiliation: Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. *Email: nematbakhsh@med.mui.ac.ir
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nematbakhsh
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pezeshki
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Eshraghi Jazi
authors.forename: Bahar
authors.initials: B
authors.lastname: Mazaheri
authors.forename: Maryam
authors.initials: M
authors.lastname: Moeini
authors.forename: Tahereh
authors.initials: T
authors.lastname: Safari
authors.forename: Fariba
authors.initials: F
authors.lastname: Azarkish
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Moslemi
authors.forename: Maryam
authors.initials: M
authors.lastname: Maleki
authors.forename: Alireza
authors.initials: A
authors.lastname: Rezaei
authors.forename: Shadan
authors.initials: Sh
authors.lastname: Saberi
authors.forename: Aghdas
authors.initials: A
authors.lastname: Dehghani
authors.forename: Maryam
authors.initials: M
authors.lastname: Malek
authors.forename: Azam
authors.initials: A
authors.lastname: Mansouri
authors.forename: Marzieh
authors.initials: M
authors.lastname: Ghasemi
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Zeinali
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Zamani
authors.forename: Mitra
authors.initials: M
authors.lastname: Navidi
authors.forename: Sima
authors.initials: S
authors.lastname: Jilanchi
authors.forename: Soheyla
authors.initials: S
authors.lastname: Shirdavani
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Ashrafi
keywords: Cisplatin; nephrotoxicity; antioxidant; trace elements; herbal agents; gender