title: Central nervous system tumours profile at a referral center in the Brazilian Amazon region, 1997-2014.
abstract: Tumours of the Central Nervous System (CNS) are an important cause of mortality from cancer. Epidemiological data on neoplams affecting the CNS are scarce in Brazil, especially in the Amazon region. The study aims at describing the histopathological profile of CNS tumours cases at a high-complexity referral cancer center. This study has described a 17-year-series profile of CNS tumours, registered at a high-complexity referral cancer center in Pará state, from January 1997 until July 2014 in the Brazilian Amazon Region. Data was gathered from histopathology reports kept in the hospital's cancer registry and 949 cases of CNS tumours were analyzed. The most common histopathology were neuroepithelial tumours (approx. 40%) and meningioma was the most frequent especific tumor histologic subtype (22.2%). Neuroepithelial tumours were more frequent in patients with ages ranging from less than a year to 19 years, whereas metastatic tumours were prevalent in patients over 40 years of age. It was not found temporal trends during the studied period. The knowledge of these tumours profile is valuable for the understanding of cancer epidemiology in the region, since its prevalence is currently underreported and more awareness on the disease is needed.
authors.affiliation: Oncológica Brasil-Ensino e Pesquisa, Belém, Pará, Brazil.|Laboratory of Epidemiology and Data Analysis, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.
authors.forename: Luis Eduardo
authors.identifier: http://orcid.org/0000-0002-4185-6871
authors.initials: LE
authors.lastname: Werneck de Carvalho
authors.affiliation: Oncológica Brasil-Ensino e Pesquisa, Belém, Pará, Brazil.|Post Gradatuation of Genetic and Molecular Biology, Universidade Federal do Pará, Belém, Pará, Brazil.
authors.forename: Jonathan Souza
authors.initials: JS
authors.lastname: Sarraf
authors.affiliation: Oncológica Brasil-Ensino e Pesquisa, Belém, Pará, Brazil.|Centro Universitário do Estado do Pará, Belém, Pará, Brazil.
authors.forename: Aluízio Augusto Pereira
authors.initials: AA
authors.lastname: Semblano
authors.affiliation: Oncológica Brasil-Ensino e Pesquisa, Belém, Pará, Brazil.|Centro Universitário do Estado do Pará, Belém, Pará, Brazil.
authors.forename: Matheus Acácio
authors.initials: MA
authors.lastname: Moreira
authors.affiliation: Oncológica Brasil-Ensino e Pesquisa, Belém, Pará, Brazil.|Laboratory of Pharmacology and Toxicology of Natural Products, Universidade Federal do Pará, Belém, Pará, Brazil.
authors.forename: Manuela Nascimento
authors.initials: MN
authors.lastname: de Lemos
authors.affiliation: Laboratory of Pharmacology and Toxicology of Natural Products, Universidade Federal do Pará, Belém, Pará, Brazil.
authors.forename: Vanessa Jóia
authors.initials: VJ
authors.lastname: de Mello
authors.affiliation: Laboratory of Pharmacology and Toxicology of Natural Products, Universidade Federal do Pará, Belém, Pará, Brazil.
authors.forename: Moisés
authors.initials: M
authors.lastname: Hamoy
authors.affiliation: Neurosurgery Department, Hospital Ophir Loyola, Belém,Pará, Brazil.
authors.forename: Mario Hermes
authors.initials: MH
authors.lastname: Nazareth Junior
authors.affiliation: Centro Universitário do Estado do Pará, Belém, Pará, Brazil.
authors.forename: Fernando Mendes
authors.initials: FM
authors.lastname: Paschoal Junior
authors.affiliation: Oncológica Brasil-Ensino e Pesquisa, Belém, Pará, Brazil.|Laboratory of Epidemiology and Data Analysis, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Adami
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D016543:Central Nervous System Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000556:secondary; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D018302:Neoplasms, Neuroepithelial / Q000453:epidemiology / Q000473:pathology; D015995:Prevalence; D012017:Referral and Consultation; D012042:Registries; D055815:Young Adult