title: Stability of R2* and quantitative susceptibility mapping of the brain tissue in a large scale multi-center study.
abstract: Multi-center studies are advantageous for enrolling participants of varying pathological and demographical conditions, and especially in neurological studies. Hence stability of the obtained quantitative R2* and susceptibility in multicenter studies is a key issue for their widespread applications. In this work, the stabilities of simultaneously obtained R2* and susceptibility are investigated and compared across 10 sites that are equipped with the same scanner and receiver coil, the same post-processing process was used to achieve consistent experiment setup. Two healthy adult volunteers (one male and female) participated in this study. High intraclass correlation coefficient was obtained for both susceptibility (0.94) and R2* (0.96). The coefficients of variance for all measurements obtained were smaller than 0.1, the largest variations of measurements in all the chosen ROIs fall within ±20% from the median value. Higher level of stability was obtained in R2* as compared to susceptibility at 1 mm resolution (P < 0.05) and at 1.5 mm (P < 0.01).
authors.affiliation: Department of Radiology, Guizhou People's Hospital, Guiyang, 550002, China.
authors.forename: Rongpin
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Radiology, Guizhou People's Hospital, Guiyang, 550002, China.
authors.forename: Guangyou
authors.initials: G
authors.lastname: Xie
authors.affiliation: Department of Radiology, Guizhou People's Hospital, Guiyang, 550002, China.
authors.forename: Maoxiong
authors.initials: M
authors.lastname: Zhai
authors.affiliation: GE Healthcare MR Research China, Beijing, 100176, China.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: GE Healthcare MR Research China, Beijing, 100176, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wu
authors.affiliation: GE Healthcare MR Research China, Beijing, 100176, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Radiology, Beijing Univ. People's Hospital, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Hong
authors.affiliation: Department of Radiology, Beijing Chaoyang Hospital, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Zhengzhou Univ. 1st Hospital, Zhengzhou, China.
authors.forename: Baohong
authors.initials: B
authors.lastname: Wen
authors.affiliation: Department of Radiology, Zhengzhou Univ. 1st Hospital, Zhengzhou, China.
authors.forename: Jingliang
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology; D001931:Brain Mapping / Q000379:methods* / Q000592:standards; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D015203:Reproducibility of Results