title: Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp. viridis Bark.
abstract: Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of cancer cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and IIα for an in silico investigation.
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, ‡Institute of Molecular Genetics and Genetic Engineering, §Institute for Biological Research "Sinisa Stankovic", and ⊥Faculty of Chemistry, University of Belgrade , 11000 Belgrade, Serbia.
authors.forename: Miroslav
authors.identifier: 0000-0002-4984-041X
authors.initials: M
authors.lastname: Novakovic
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, ‡Institute of Molecular Genetics and Genetic Engineering, §Institute for Biological Research "Sinisa Stankovic", and ⊥Faculty of Chemistry, University of Belgrade , 11000 Belgrade, Serbia.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Nikodinovic-Runic
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, ‡Institute of Molecular Genetics and Genetic Engineering, §Institute for Biological Research "Sinisa Stankovic", and ⊥Faculty of Chemistry, University of Belgrade , 11000 Belgrade, Serbia.
authors.forename: Jovana
authors.initials: J
authors.lastname: Veselinovic
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, ‡Institute of Molecular Genetics and Genetic Engineering, §Institute for Biological Research "Sinisa Stankovic", and ⊥Faculty of Chemistry, University of Belgrade , 11000 Belgrade, Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ilic-Tomic
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, ‡Institute of Molecular Genetics and Genetic Engineering, §Institute for Biological Research "Sinisa Stankovic", and ⊥Faculty of Chemistry, University of Belgrade , 11000 Belgrade, Serbia.
authors.forename: Vera
authors.initials: V
authors.lastname: Vidakovic
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, ‡Institute of Molecular Genetics and Genetic Engineering, §Institute for Biological Research "Sinisa Stankovic", and ⊥Faculty of Chemistry, University of Belgrade , 11000 Belgrade, Serbia.
authors.forename: Vele
authors.initials: V
authors.lastname: Tesevic
authors.affiliation: Institute of Chemistry, Technology and Metallurgy, ‡Institute of Molecular Genetics and Genetic Engineering, §Institute for Biological Research "Sinisa Stankovic", and ⊥Faculty of Chemistry, University of Belgrade , 11000 Belgrade, Serbia.
authors.forename: Slobodan
authors.initials: S
authors.lastname: Milosavljevic
mesh_terms: D029661:Alnus / Q000737:chemistry; D002460:Cell Line / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry*; D059003:Topoisomerase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009828:Oleanolic Acid / Q000031:analogs & derivatives
chemical_list: D053978:Pentacyclic Triterpenes; D059003:Topoisomerase Inhibitors; D014315:Triterpenes; C000622052:27-hydroxyalphitolic acid; C000622053:27-hydroxybetulinic acid; C412811:maslinic acid; D009828:Oleanolic Acid