title: Ligand-Promoted meta-C-H Functionalization of Benzylamines.
abstract: Meta-C-H functionalization of benzylamines has been developed using a PdII/transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO2Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand.
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Marcus E
authors.initials: ME
authors.lastname: Farmer
authors.affiliation: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
authors.forename: Jin-Quan
authors.identifier: 0000-0003-3560-5774
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000586:Amination; D001596:Benzylamines / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D008024:Ligands; D010165:Palladium / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001596:Benzylamines; D008024:Ligands; D011728:Pyridones; D010165:Palladium; C017679:2-hydroxypyridine
keywords: amination; benzylamines; chlorination; meta-C−H arylation; pyridone ligand