title: Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes.
abstract: A series of stable phosphonium salts have been synthesized via a novel four-component reaction of an arene nucleophile, 2-heteroatom substituted aryl aldehyde, and phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of a variety of bis-heteroarenes, providing an efficient alternative method to the classical cross-coupling strategies.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, 11677, Taiwan, R.O.C.
authors.forename: Yi-Ru
authors.initials: YR
authors.lastname: Chen
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, 11677, Taiwan, R.O.C.
authors.forename: Ganapuram Madhusudhan
authors.initials: GM
authors.lastname: Reddy
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, 11677, Taiwan, R.O.C.
authors.forename: Shao-Hao
authors.initials: SH
authors.lastname: Hong
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, 11677, Taiwan, R.O.C.
authors.forename: Ying-Zheng
authors.initials: YZ
authors.lastname: Wang
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, 11677, Taiwan, R.O.C.
authors.forename: Jhen-Kuei
authors.initials: JK
authors.lastname: Yu
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, 11677, Taiwan, R.O.C.
authors.forename: Wenwei
authors.identifier: 0000-0002-1121-072X
authors.initials: W
authors.lastname: Lin
keywords: Wittig reactions; bis-heteroarenes; cross-coupling; multicomponent reactions; organophosphonium salts