title: Thalassiolin D: a new flavone O-glucoside Sulphate from the seagrass Thalassia hemprichii.
abstract: Thalassiolin D, a new flavone O-glucoside sulphate along with three flavonoids, two steroids, p-hydroxybenzoic acid, 4,4'-dihydroxybenzophenone and nitrogen compound, octopamine were isolated from the seagrass Thalassia hemprichii, collected from the Saudi Red Sea coast. By extensive spectroscopic analysis including 1D and 2D NMR and MS data, the structure of the new compound was elucidated as diosmetin 7-O-β-glucosyl-2″-sulphate. The new compound displayed moderately in vitro antiviral HCV protease activity with IC50value 16 μM.
authors.affiliation: a Faculty of Marine Sciences, Marine Chemistry Department , King Abdulaziz University , Jeddah , Saudi Arabia.|b Phytochemistry and Plant Systematic Department , National Research Centre , Cairo , Egypt.
authors.forename: Usama W
authors.initials: UW
authors.lastname: Hawas
authors.affiliation: c Pharmacognosy Department , National Research Centre , Cairo , Egypt.
authors.forename: Lamia T
authors.initials: LT
authors.lastname: Abou El-Kassem
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects; D031321:Hydrocharitaceae / Q000737:chemistry*; D019156:Indian Ocean; D015394:Molecular Structure; D064209:Phytochemicals / Q000302:isolation & purification / Q000494:pharmacology; D012529:Saudi Arabia; D013431:Sulfates / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D047309:Flavones; D005960:Glucosides; D064209:Phytochemicals; D013431:Sulfates
keywords: Red Sea; Seagrass; Thalassia hemprichii; flavone glucoside sulphate