title: Diagnostic accuracy of salivary creatinine, urea, and potassium levels to assess dialysis need in renal failure patients.
abstract: BACKGROUND
  The prevalence of chronic renal failure is increasing because of increase in chronic debilitating diseases and progressing age of population. These patients experience accumulation of metabolic byproducts and electrolyte imbalance, which has harmful effects on their health. Timely hemodialysis at regular intervals is a life-saving procedure for these patients. Salivary diagnostics is increasingly used as an alternative to the traditional methods. Thus, the aim of the present study was to determine the diagnostic efficacy of saliva in chronic renal failure patients.
  
  
  METHODS
  This case-control study included 82 individuals, of which 41 were chronic renal failure patients and 41 were age- and sex-matched controls. Blood and saliva were collected and centrifuged. Serum and supernatant saliva were used for biochemical analysis. Serum and salivary urea, creatinine, sodium, potassium, calcium, and phosphorus were evaluated and correlated in chronic renal failure patients using unpairedt-test, Pearson's correlation coefficient, diagnostic validity tests, and receiver operative curve.
  
  
  RESULTS
  When compared to serum; salivary urea, creatinine, sodium, and potassium showed diagnostic accuracy of 93%, 91%, 73%, and 89%, respectively, based on the findings of study.
  
  
  CONCLUSIONS
  It can be concluded that salivary investigation is a dependable, noninvasive, noninfectious, simple, and quick method for screening the mineral and metabolite values of high-risk patients and monitoring the renal failure patients.
authors.affiliation: Department of Oral Pathology, St. Joseph Dental College, Eluru, Andhra Pradesh, India.
authors.forename: Bhavana S
authors.initials: BS
authors.lastname: Bagalad
authors.affiliation: Department of Oral Pathology, College of Dental Sciences, Davangere, Karnataka, India.
authors.forename: K P
authors.initials: KP
authors.lastname: Mohankumar
authors.affiliation: Department of Oral Pathology, College of Dental Sciences, Davangere, Karnataka, India.
authors.forename: G S
authors.initials: GS
authors.lastname: Madhushankari
authors.affiliation: Oral and Maxillofacial Pathology Centre, Belgaum, Karnataka, India.
authors.forename: Mandana
authors.initials: M
authors.lastname: Donoghue
authors.affiliation: Department of Oral Pathology, St. Joseph Dental College, Eluru, Andhra Pradesh, India.
authors.forename: Puneeth Horatti
authors.initials: PH
authors.lastname: Kuberappa
keywords: Creatinine; dialysis; renal insufficiency; saliva; serum; urea