title: Advancing host-directed therapy for tuberculosis.
abstract: Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT)s-including new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the problems associated with current treatment regimens. By investigating the interaction between macrophages and the intracellular parasiteToxoplasma gondii(T. gondii), we uncovered that infection-induced signaling pathways suggest possibilities for the development of novel therapeutic modalities for TB that target the intracellular signaling pathways permitting the replication ofMycobacterium tuberculosis(MTB).
authors.affiliation: Department of Molecular and Life Science, Hanyang University, Ansan 15588, S. Korea. ; Department of Bio-nanotechnology, Hanyang University, Seoul, 04673, S. Korea.
authors.forename: Chul-Su
authors.initials: CS
authors.lastname: Yang
keywords: Mycobacterium tuberculosis; Toxoplasma gondii GRA7; macrophages; protein-protein interactions