title: Why we forget our dreams: Acetylcholine and norepinephrine in wakefulness and REM sleep.
abstract: The ascending fibers releasing norepinephrine and acetylcholine are highly active during wakefulness. In contrast, during rapid-eye-movement sleep, the neocortical tone is sustained mainly by acetylcholine. By comparing the different physiological features of the norepinephrine and acetylcholine systems in the light of the GANE (glutamate amplifies noradrenergic effects) model, we suggest how to interpret some functional differences between waking and rapid-eye-movement sleep.
authors.affiliation: Department of Biotechnology and Biosciences and Center for Neuroscience of Milan,University of Milano-Bicocca,20128 Milan,Italyandrea.becchetti@unimib.ithttp://www.btbs.unimib.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Becchetti
authors.affiliation: Department of Biosciences,University of Milano,20133 Milan,Italyalida.amadeo@unimi.ithttp://www.dbs.unimi.it.
authors.forename: Alida
authors.initials: A
authors.lastname: Amadeo
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D018698:Glutamic Acid; D006801:Humans; D009638:Norepinephrine / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D018698:Glutamic Acid; D000109:Acetylcholine; D009638:Norepinephrine