title: Phenolic Compounds from the Rhizomes of Smilax china L. and Their Anti-Inflammatory Activity.
abstract: A new triflavanoid, kandelin B-5 (1), was isolated from the rhizomes ofSmilax chinaL., together with six known phenylpropanoid substituted flavan-3-ols (2-7), nine flavonoids (8-16), two stilbenoids (17,18), and two other compounds (19,20). The structure of compound1was determined on the basis of 1D, 2D NMR and HR-ESI-MS data, as well as chemical method. Compounds2-5,8-12,15,17, and19were evaluated for anti-inflammatory activity. Only compounds10,15and17showed slightly IL-1β expression inhibitory activities on LPS induced THP-1 cells, with inhibition rate of 15.8%, 37.3%, and 35.8%, respectively, at concentration of 50 μg/mL.
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. vanbenchat@126.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhong
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. hudeng19900922@126.com.
authors.forename: Deng
authors.initials: D
authors.lastname: Hu
authors.affiliation: Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lianbingh@hotmail.com.
authors.forename: Lian-Bing
authors.initials: LB
authors.lastname: Hou
authors.affiliation: Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. songluyao.nice@163.com.
authors.forename: Lu-Yao
authors.initials: LY
authors.lastname: Song
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. zhangyj@mail.kib.ac.cn.
authors.forename: Ying-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. yxie201203@126.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xie
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. lwtian@smu.edu.cn.
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Tian
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry*; D032281:Smilax / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D016207:Cytokines; D005419:Flavonoids; D010936:Plant Extracts
keywords: Smilax china; anti-inflammatory activity; phenolic compounds