title: Rosmarinus officinalis L. ameliorates titanium dioxide nanoparticles and induced some toxic effects in rats' blood.
abstract: Titanium dioxide nanoparticles (TiO2NPs) have been widely used as a white pigment in food and drugs. The most important route of human exposure to TiO2is through food and drug products containing TiO2additives. This study investigates the efficacy of an oral traditional use of rosemary extract in ameliorating some toxic effects induced on blood of TiO2NP-intoxicated rats. Rats were given rosemary extract via intragastric administration 1 h before the intragastric administration of 100 mg/kg/day TiO2NPs (10 nm) for 60 days. TiO2NPs significantly increased serum cholesterol, glucose, and triglyceride levels of rats. They also induced significant oxidative stress and inflammatory and caused DNA damage in peripheral blood leukocytes. The rosemary extract appears to have a significant protective effect by lowering glucose level properties, restoring the lipid profile and showing an antioxidative, anti-inflammatory, and antigenotoxic properties against TiO2NPs toxicity. In conclusion, this study gives an encouraging scientific basis for consumers of rosemary leaves to keep on with this culinary habit.
authors.affiliation: Laboratory of Histology and Cytogenetics (Research unit of Genetic, Genotoxicity and Childhood Illness UR12ES10), Faculty of Medicine, University of Monastir, Street Avicenne, 5019, Monastir, Tunisia. intissar.grissa01@gmail.com.
authors.forename: Intissar
authors.identifier: http://orcid.org/0000-0003-4644-6908
authors.initials: I
authors.lastname: Grissa
authors.affiliation: Laboratory of Histology and Cytogenetics (Research unit of Genetic, Genotoxicity and Childhood Illness UR12ES10), Faculty of Medicine, University of Monastir, Street Avicenne, 5019, Monastir, Tunisia.
authors.forename: Lobna
authors.initials: L
authors.lastname: Ezzi
authors.affiliation: Laboratory of Histology and Cytogenetics (Research unit of Genetic, Genotoxicity and Childhood Illness UR12ES10), Faculty of Medicine, University of Monastir, Street Avicenne, 5019, Monastir, Tunisia.
authors.forename: Sana
authors.initials: S
authors.lastname: Chakroun
authors.affiliation: Laboratory of Histology and Cytogenetics (Research unit of Genetic, Genotoxicity and Childhood Illness UR12ES10), Faculty of Medicine, University of Monastir, Street Avicenne, 5019, Monastir, Tunisia.
authors.forename: Abir
authors.initials: A
authors.lastname: Mabrouk
authors.affiliation: Department of Hematology, Centre Hospitalier Universitaire Taher Sfar, Mahdia, Tunisia.
authors.forename: Azer Ben
authors.initials: AB
authors.lastname: Saleh
authors.affiliation: Department of Hematology, Centre Hospitalier Universitaire Taher Sfar, Mahdia, Tunisia.
authors.forename: Hamadi
authors.initials: H
authors.lastname: Braham
authors.affiliation: Laboratory of Histology and Cytogenetics (Research unit of Genetic, Genotoxicity and Childhood Illness UR12ES10), Faculty of Medicine, University of Monastir, Street Avicenne, 5019, Monastir, Tunisia.
authors.forename: Zohra
authors.initials: Z
authors.lastname: Haouas
authors.affiliation: Laboratory of Histology and Cytogenetics (Research unit of Genetic, Genotoxicity and Childhood Illness UR12ES10), Faculty of Medicine, University of Monastir, Street Avicenne, 5019, Monastir, Tunisia.
authors.forename: Hassen Ben
authors.initials: HB
authors.lastname: Cheikh
mesh_terms: D000818:Animals; D006801:Humans; D053768:Metal Nanoparticles / Q000633:toxicity; D053758:Nanoparticles / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D027542:Rosmarinus; D014025:Titanium / Q000633:toxicity*
chemical_list: C009495:titanium dioxide; D014025:Titanium
keywords: Atherogenesis; Genotoxicity; Il-6; Oxidative stress; Rosemary aqueous extract; TiO2 NPs