title: Selective synthesis of mono- and bis-butenolide α-aminomethyl adducts.
abstract: The selective installation of α-methylamine residues at the butenolide core is described using α-bromomethylene-γ-butenolide and primary as well as secondary amines in methanol at 0 °C. The preparation of mono- and bis-butenolide α-adducts is described. Bis-γ-butenolide adducts as well as mono α-aminomethyl-γ-butenolides can be selectively obtained depending on the nature of the reacting primary amine. In contrast, the use of secondary amines allows two different pathways leading either to the expected amino derivatives or to the formation of a C-O bond.
authors.affiliation: Université de Tunis El Manar, Faculté des Sciences de Tunis, Laboratoire de Synthèse Organique Sélective et Hétérocyclique-Evaluation de l'Activité Biologique, 2092 Tunis, Tunisia.
authors.forename: Arbia
authors.initials: A
authors.lastname: Talbi
authors.forename: Aïcha
authors.initials: A
authors.lastname: Arfaoui
authors.forename: Talia
authors.initials: T
authors.lastname: Bsaibess
authors.forename: Mohamed
authors.initials: M
authors.lastname: Lotfi Efrit
authors.forename: Anne
authors.initials: A
authors.lastname: Gaucher
authors.forename: Damien
authors.initials: D
authors.lastname: Prim
authors.forename: Hédi
authors.initials: H
authors.lastname: M Rabet