title: EARLY DETECTION OF RETINAL HEMANGIOBLASTOMAS IN VON HIPPEL-LINDAU DISEASE USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY.
abstract: OBJECTIVE
  To study the use of ultra-widefield fluorescein angiography (UWF FA) in the detection and management of retinal capillary hemangioblastomas in patients with von Hippel-Lindau disease.
  
  
  METHODS
  This is a retrospective study of patients with von Hippel-Lindau disease who underwent UWF FA using the Optos camera at a single center from June 2009 to May 2015. The clinical use of UWF FA was reviewed, and the number of hemangioblastomas identified on UWF FA was compared with ophthalmoscopy and a simulated seven standard field (7SF) FA montage.
  
  
  RESULTS
  Twenty eyes of 10 patients were identified. Only 33% of lesions seen on UWF FA were also found on ophthalmoscopy, and 88% of lesions visualized on UWF FA were located outside the 7SF overlay. In 5 eyes that had gaze steering, 18% of lesions could be visualized only on gaze-steered images. For the 14 eyes with data available, 6 had procedures recommended and 8 eyes observed based on data from UWF FA. One of 20 eyes had a lesion on ophthalmoscopy that was missed by imaging.
  
  
  CONCLUSIONS
  Ultra-widefield FA using the Optos camera is helpful for the evaluation and management of patients with von Hippel-Lindau disease. The UWF FA with gaze steering appears to detect more hemangioblastomas than ophthalmoscopy and conventional angiography.
authors.affiliation: Retina Division, Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Chen
authors.affiliation: Retina Division, Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Sanfilippo
authors.affiliation: Retina Division, Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Aaron
authors.initials: A
authors.lastname: Nagiel
authors.affiliation: Retina Division, Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Hamid
authors.initials: H
authors.lastname: Hosseini
authors.affiliation: Retina Division, Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Devery
authors.initials: D
authors.lastname: Mitchell
authors.affiliation: Retinal Disorders and Ophthalmic Genetics Division, Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Colin A
authors.initials: CA
authors.lastname: McCannel
authors.affiliation: Retina Division, Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Schwartz
authors.affiliation: Retina Division, Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Tara A
authors.initials: TA
authors.lastname: McCannel
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003941:Diagnostic Techniques, Ophthalmological; D042241:Early Diagnosis; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D018325:Hemangioblastoma / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019572:Retinal Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology; D012189:Retrospective Studies; D055815:Young Adult; D006623:von Hippel-Lindau Disease / Q000150:complications*