title: Favorable Pulse Wave Augmentation Indices and Left Ventricular Diastolic Profile in β-Thalassemia Minor.
abstract: β-Thalassemia minor (β-Τm) is associated with rheological and biochemical alterations that can affect cardiovascular function. We aimed to evaluate the elastic arterial properties and the pulse wave augmentation indices in a population of patients with β-Τm. Seventy-five individuals with β-Τm (age 55.5 [42.75-65.25], women 48%) and 127 controls (age 57 years [48-63], women 55.1%) underwent comprehensive echocardiographic evaluation and applanation tonometry of the radial and femoral artery. Pulse wave analysis revealed that augmentation pressure, augmentation index (AIx), and heart rate-corrected AIx were significantly lower (median [interquartile range]: 8.75 [4.625-13] vs 11 [6.5-14.5], P = .017; 26.5 [17.5-33.375] vs 30.5 [20.75-37.5], P = .014; and 22.25 [15.125-29.5] vs 27 [20.5-33], P = .008, respectively) in the β-Τm group compared to controls. The left atrial active emptying volume was significantly lower and the isovolumic relaxation time was shorter in the β-Τm group compared to the control group (10.2 [7.4-14.4] vs 12.0 [8.6-15.8], P = .040 and 78 [70-90] vs 90 [70-104], P = .034, respectively). β-Thalassemia minor is associated with favorable pulse wave augmentation indices and left ventricular diastolic function profile in asymptomatic individuals with cardiovascular risk factors.
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Chamaidi
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Karagiannis
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Christidi
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Parisis
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Koutrakis
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: Andrew
authors.initials: A
authors.lastname: Xanthopoulos
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Skoularigis
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: Gregory
authors.initials: G
authors.lastname: Giamouzis
authors.affiliation: 1 Department of Cardiology, Larissa University Hospital, Larissa, Greece.
authors.forename: Filippos K
authors.initials: FK
authors.lastname: Triposkiadis
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003971:Diastole / Q000502:physiology*; D004452:Echocardiography; D005260:Female; D006115:Greece; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008365:Manometry; D008875:Middle Aged; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D017086:beta-Thalassemia / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D008055:Lipids
keywords: arterial stiffness; diastolic function; β-thalassemia minor