title: Introduction: T Cell Trafficking in Inflammation and Immunity.
abstract: T cell migration across vascular endothelium is essential for T cell responses, as through the expression of specific tissue-homing receptors, these cells then access peripheral tissues, with the goal of eliminating invading pathogens and/or tumor cells. However, aberrant trafficking of T cells to peripheral tissues contributes to the development of most chronic inflammatory diseases. Very little is known about the mechanisms by which T cell trafficking is regulated during inflammation, and it is thus difficult to target this aspect of pathology for the development of new therapies. It is therefore important to understand the pathways involved in regulating the recruitment of immune cells.
authors.affiliation: Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
authors.forename: Myriam
authors.initials: M
authors.lastname: Chimen
authors.affiliation: Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, West Midlands, B15 2TT, UK.
authors.forename: Bonita H R
authors.initials: BH
authors.lastname: Apta
authors.affiliation: Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. h.m.mcgettrick@bham.ac.uk.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Mcgettrick
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology*
keywords: Adhesion; Adipokines; Adiponectin; Cell culture; Cytokines; Endothelial cells; Flow; Inflammation; Leptin; Lymphocyte; Migration; PEPITEM; Sphingosine-1-phosphate