title: Antioxidative and Anti-Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities ofAcer ginnala.
abstract: Chromatographic isolation of the 80% MeOH extract ofAcer ginnala(AG) yielded seven galloyl derivatives: gallic acid (1), ginnalin B (2), acertannin (3), maplexin D (4), maplexin E (5), quercetin-3-O-(2''-galloyl)-α-L-rhamnopyranoside (6), and kaempferol-3-O-(2''-galloyl)-α-L-rhamnopyranoside (7). This is the first study to report the isolation of compounds4and5from AG. Galloyl derivatives3-7exhibited potent radical scavenging activities, with5and7showing particularly strong inhibitory activities against nitric oxide production in lipopolysaccharides- (LPS-) stimulated RAW264.7 cells. In addition, oral administration of AG extract (500 mg/kg b.w.) improved symptoms of hyperglycemia and blunted the increases in serum GOT/GPT levels in a rat model of streptozotocin-induced diabetes. These results suggest that galloyl derivatives (1-7) are antioxidant and anti-inflammatory agents and that AG extract has potential as a functional material or novel herbal medicine for treating diabetes mellitus.
authors.affiliation: Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Kwan Hee
authors.initials: KH
authors.lastname: Park
authors.affiliation: Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Kyu Hyeong
authors.initials: KH
authors.lastname: Yoon
authors.affiliation: Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.affiliation: Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Thi Tam
authors.initials: TT
authors.lastname: Le
authors.affiliation: Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Hye Sin
authors.initials: HS
authors.lastname: Ahn
authors.affiliation: Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Seong Hye
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors.forename: Min Won
authors.identifier: 0000-0002-8018-5652
authors.initials: MW
authors.lastname: Lee