title: Aging of bone marrow mesenchymal stromal/stem cells: Implications on autologous regenerative medicine.
abstract: With their proliferation, differentiation into specific cell types, and secretion properties, mesenchymal stromal/stem cells (MSC) are very interesting tools to be used in regenerative medicine. Bone marrow (BM) was the first MSC source characterized. In the frame of autologous MSC therapy, it is important to detect donor's parameters affecting MSC potency. Age of the donors appears as one parameter that could greatly affect MSC properties. Moreover, in vitro cell expansion is needed to obtain the number of cells necessary for clinical developments. It will lead to in vitro cell aging that could modify cell properties. This review recapitulates several studies evaluating the effect of in vitro and in vivo MSC aging on cell properties.
authors.affiliation: CNRS-UL, UMR 7365, IMoPA, Faculté de Médecine, Vandoeuvre-lès-Nancy, France.|CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.
authors.forename: N
authors.initials: N
authors.lastname: Charif
authors.affiliation: CNRS-UL, UMR 7365, IMoPA, Faculté de Médecine, Vandoeuvre-lès-Nancy, France.|CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Li
authors.affiliation: CNRS-UL, UMR 7365, IMoPA, Faculté de Médecine, Vandoeuvre-lès-Nancy, France.|CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.
authors.forename: L
authors.initials: L
authors.lastname: Targa
authors.affiliation: CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.|Centre de Recherche Biomedicale, Calmette Hospital, Kunming, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.affiliation: CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.|Centre de Recherche Biomedicale, Calmette Hospital, Kunming, China.
authors.forename: J S
authors.initials: JS
authors.lastname: Ye
authors.affiliation: CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.|College Médical, Université de Wuhan, Wuhan, Chine.
authors.forename: Y P
authors.initials: YP
authors.lastname: Li
authors.affiliation: CNRS-UL, UMR 7365, IMoPA, Faculté de Médecine, Vandoeuvre-lès-Nancy, France.|CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.|CHRU de Nancy, Unité de Thérapie Cellulaire et Tissulaire (UTCT) (FR CNRS-INSERM-UL-CHU), Vandoeuvre-Lès-Nancy, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Stoltz
authors.affiliation: CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.|Centre de Recherche sur les cellules souches, Beijing et Tianjin, China.
authors.forename: H Z
authors.initials: HZ
authors.lastname: Han
authors.affiliation: CNRS-UL, UMR 7365, IMoPA, Faculté de Médecine, Vandoeuvre-lès-Nancy, France.|CNRS - GDRI 0851, France-Chine ≪ Stem cells and Regenerative medicine ≫.
authors.forename: N
authors.initials: N
authors.lastname: de Isla
mesh_terms: D000375:Aging; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D016922:Cellular Senescence; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism; D018384:Oxidative Stress; D044968:Regenerative Medicine; D059505:Telomere Homeostasis
keywords: Mesenchymal stromal/stem cells; aging; bone marrow; regenerative medicine