title: Pathology of Aging in NOD scid gamma Female Mice.
abstract: In the past decade, NOD.Cg- PrkdcscidIl2rgtm1Wjl/SzJ (NSG, NOD scid gamma) mice have become a model of choice in several areas of biomedical research; however, comprehensive data on their spontaneous age-related pathology are not currently available in the literature. The prevalence of spontaneous morbidity affecting aged NSG female breeders enrolled in a parasitology study was documented with classification of neoplastic and non-neoplastic (inflammatory, metabolic, degenerative) lesions. Malignant mammary neoplasms were most commonly diagnosed, often accompanied by pulmonary metastases, while a low frequency of lymphoma and histiocytic sarcoma was documented. The major inflammatory conditions were suppurative pleuropneumonia and bronchopneumonia with abscess formation, from which Pasteurella pneumotropica was commonly isolated, followed by otitis media. Both inflammatory and degenerative lesions of the genital tract were identified, along with neoplasms such as endometrial yolk sac carcinomas and granulosa cell tumors. Novel conditions identified included renal tubular degeneration and necrosis associated with 2 concurrent types of intranuclear inclusions, focal or multifocal hyperostosis of the skull, and neuroendocrine tumors of the mesometrium. The majority of degenerative lesions that affected the genital tract, endocrine, and skeletal systems did not represent the actual underlying cause of death but rather were considered incidental findings. This study indicates that both inflammatory and neoplastic conditions contribute to morbidity and mortality in experimentally manipulated aged female NSG mice.
authors.affiliation: 1 Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY, USA.
authors.forename: Sara F
authors.initials: SF
authors.lastname: Santagostino
authors.affiliation: 2 Tri-Institutional Training Program in Laboratory Animal Medicine and Science, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY, USA.|3 Center for Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
authors.forename: Rodolfo J Ricart
authors.initials: RJR
authors.lastname: Arbona
authors.affiliation: 2 Tri-Institutional Training Program in Laboratory Animal Medicine and Science, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY, USA.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Nashat
authors.affiliation: 1 Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY, USA.
authors.forename: Julie R
authors.initials: JR
authors.lastname: White
authors.affiliation: 1 Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY, USA.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Monette
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008137:Longitudinal Studies; D051379:Mice; D016688:Mice, Inbred NOD / Q000502:physiology*; D016513:Mice, SCID / Q000502:physiology*
keywords: aging; background lesions; female; interleukin-2 receptor gamma chain knockout; mouse; non-obese diabetic; pathology; severe combined immunodeficiency