title: Comparison of Hypersensitivity Reactions to Carboplatin Retreatment in Gynecologic Cancer Patients between One and Two Hour Infusions: a Randomized Trial Study
abstract: Objective: To compare the incidence rate of carboplatin hypersensitivity reactions (HSRs) in gynecologic cancer
  patients receiving one-hour or two-hour carboplatin retreatment infusions. Setting: A Prospective Randomized
  Controlled Trial. Methods: Recurrent gynecologic cancer patients 25 to 80-years of age who were scheduled to receive
  carboplatin retreatment after previously receiving at least six cycles of carboplatin without a history of platinum allergy
  were invited to enroll. They were randomized to receive either a one-hour or two-hour carboplatin infusion in each
  cycle. The nurses recorded any occurrence of HSR. Patients who developed carboplatin HSR were discontinued from
  the study. Results: Forty-five patients were enrolled and randomized to receive either a one-hour carboplatin infusion
  arm in 69 cycles or a two-hour infusion arm in 67 cycles. Both groups were well balanced regarding median age, body
  mass index, type of cancer, history of drug allergy, median platinum free interval time, median total number of previous
  carboplatin cycles, premedication type, regimen and median total dose of carboplatin. Five (3.67%) of the 136 cycles
  resulted in carboplatin HSR, all of which were Grade 1. Of these, four cycles developed HSR during the one-hour
  infusion and only one cycle with a two-hour infusion (P=0.37). The onset of carboplatin HSR occurred within 30-105
  minutes after infusion start. Conclusion: Extending the carboplatin infusion time to two hours from one hour did not
  significantly decrease carboplatin HSR.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand . Email: psuprase@gmail.com
authors.forename: Weerawich
authors.initials: W
authors.lastname: Pornwattanakrilert
authors.forename: Prapaporn
authors.initials: P
authors.lastname: Suprasert
keywords: Carboplatin; hypersensitivity reaction; gynecologic cancer; extended infusion time