title: Exploring and validating physicochemical properties of mangiferin through GastroPlus®software.
abstract: OBJECTIVE
  Mangiferin (Mgf), a promising therapeutic polyphenol, exhibits poor oral bioavailability. Hence, apt delivery systems are required to facilitate its gastrointestinal absorption. The requisite details on its physicochemical properties have not yet been well documented in literature. Accordingly, in order to have explicit insight into its physicochemical characteristics, the present work was undertaken using GastroPlus™ software.
  
  
  RESULTS
  Aqueous solubility (0.38 mg/ml), log P (-0.65), Peff(0.16 × 10-4cm/s) and ability to act as P-gp substrate were defined. Potency to act as a P-gp substrate was verified through Caco-2 cells, while Peffwas estimated through single pass intestinal perfusion studies. Characterization of Mgf through transmission electron microscopy, differential scanning calorimetry, infrared spectroscopy and powder x-ray diffraction has also been reported.
  
  
  CONCLUSIONS
  The values of physicochemical properties for Mgf reported in the current manuscript would certainly enable the researchers to develop newer delivery systems for Mgf.
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India.
authors.forename: Rajneet Kaur
authors.initials: RK
authors.lastname: Khurana
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India.
authors.forename: Ranjot
authors.initials: R
authors.lastname: Kaur
authors.affiliation: Centre with Potential for Excellence in Biomedical Sciences, Panjab University, Chandigarh 160014, India; Centre with Potential for Excellence in Biomedical Sciences, Panjab University, Chandigarh 160014, India.
authors.forename: Manninder
authors.initials: M
authors.lastname: Kaur
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India.
authors.forename: Rajpreet
authors.initials: R
authors.lastname: Kaur
authors.affiliation: D.A.V. College, Sector 10 D, Chandigarh 160011, India; D.A.V. College, Sector 10 D, Chandigarh 160011, India.
authors.forename: Jasleen
authors.initials: J
authors.lastname: Kaur
authors.affiliation: Department of Botany, G.H.G. Khalsa College, Gurusar Sadhar, Ludhiana 141104, India; Department of Botany, G.H.G. Khalsa College, Gurusar Sadhar, Ludhiana 141104, India.
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.affiliation: University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India; UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160014, India; UGC-Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences), Panjab University, Chandigarh 160014, India.
authors.forename: Bhupinder
authors.initials: B
authors.lastname: Singh
keywords: Mangifera indica; P-gp substrate; anticancer; antioxidants; simulations