title: Action of Bacopa monnieri to antagonize cisplatin-induced emesis in Suncus murinus (house musk shrew).
abstract: Bacopa monnieri (BM, family Scrophulariaceae) is used in several traditional systems of medicine for the management of epilepsy, depression, neuropathic pain, sleep disorders and memory deficits. The present study investigated the potential of BM methanol (BM-MetFr) and BM n-butanol fractions (BM-ButFr) to reduce chemotherapy-induced emesis in Suncus murinus (house musk shrew). Cisplatin (30 mg/kg, i.p.) reliably induced retching and/or vomiting over a 2 day period. BM-MetFr (10-40 mg/kg, s.c.) and BM-ButFr (5-20 mg/kg, s.c.) antagonized the retching and/or vomiting response by ∼59.4% (p < 0.05) and 78.9% (p < 0.05), respectively, while the 5-HT3receptor antagonist, palonosetron (0.5 mg/kg, s.c.), reduced the response by ∼71% (p < 0.05). The free radical scavenger/antioxidant, N-(2-mercaptopropionyl)-glycine (30-300 mg/kg, s.c.) reduced the retching and/or vomiting response occurring on day one non-significantly by 44% (p > 0.05). In conclusion, the n-butanol fractions of BM have anti-emetic activity comparable with palonosetron and MPG. BM may be useful alone or in combination with other anti-emetic drugs for the treatment of chemotherapy-induced emesis in man.
authors.affiliation: Department of Pharmacy, University of Swabi, Swabi, Pakistan; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ullah
authors.affiliation: Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.
authors.forename: Fazal
authors.initials: F
authors.lastname: Subhan
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
authors.forename: Zengbing
authors.initials: Z
authors.lastname: Lu
authors.affiliation: School of Health Sciences, Caritas Institute of Higher Education, Tseung Kwan O, N.T., Hong Kong.
authors.forename: Sze Wa
authors.initials: SW
authors.lastname: Chan
authors.affiliation: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; Brain and Mind Institute, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong. Electronic address: jar@cuhk.edu.hk.
authors.forename: John A
authors.initials: JA
authors.lastname: Rudd
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D034681:Bacopa / Q000737:chemistry*; D002945:Cisplatin / Q000009:adverse effects*; D007546:Isoquinolines / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D000077924:Palonosetron; D010936:Plant Extracts / Q000494:pharmacology*; D011812:Quinuclidines / Q000494:pharmacology / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D012788:Shrews; D008625:Tiopronin / Q000494:pharmacology / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D007546:Isoquinolines; D010936:Plant Extracts; D011812:Quinuclidines; D012702:Serotonin Antagonists; D000077924:Palonosetron; D008625:Tiopronin; D002945:Cisplatin
keywords: Anti-emetic; Bacopa monnieri; Cisplatin; Emesis; Suncus murinus