title: Sleep patterns, sleep disorders and mammographic density in spanish women: The DDM-Spain/Var-DDM study.
abstract: We explored the relationship between sleep patterns and sleep disorders and mammographic density (MD), a marker of breast cancer risk. Participants in the DDM-Spain/var-DDM study, which included 2878 middle-aged Spanish women, were interviewed via telephone and asked questions on sleep characteristics. Two radiologists assessed MD in their left craneo-caudal mammogram, assisted by a validated semiautomatic-computer tool (DM-scan). We used log-transformed percentage MD as the dependent variable and fitted mixed linear regression models, including known confounding variables. Our results showed that neither sleeping patterns nor sleep disorders were associated with MD. However, women with frequent changes in their bedtime due to anxiety or depression had higher MD (eβ:1.53;95%CI:1.04-2.26).
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. Electronic address: ampedraza@isciii.es.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Pedraza-Flechas
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Lope
authors.affiliation: Aragon Breast Cancer Screening Program, Health Service of Aragon, Zaragoza, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Moreo
authors.affiliation: Navarra Breast cancer Screening Program, Public Health Institute, Pamplona, Spain.
authors.forename: Nieves
authors.initials: N
authors.lastname: Ascunce
authors.affiliation: Valencia Breast Cancer Screening Program, General Directorate Public Health, Valencia, Spain.
authors.forename: Josefa
authors.initials: J
authors.lastname: Miranda-García
authors.affiliation: Cancer Prevention and Control Unit, Catalan Institute of Oncology (ICO), Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Vidal
authors.affiliation: Balearic Islands Breast Cancer Screening Program, Health Promotion for Women and Childhood, General Directorate Public Health and Participation, Regional Authority of Health and Consumer Affairs, Balearic Islands, Palma de Mallorca, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Sánchez-Contador
authors.affiliation: Galicia Breast Cancer Screening Program, Regional Authority of Health, Galicia Regional Government, Corunna, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Santamariña
authors.affiliation: Castile-Leon Breast Cancer Screening Program, General Directorate Public Health SACYL, Burgos, Castile-Leon, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Pedraz-Pingarrón
authors.affiliation: Institute of Computer Technology, Universitat Politècnica de València, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Llobet
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Aragonés
authors.affiliation: Valencia Breast Cancer Screening Program, General Directorate Public Health, Valencia, Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Salas-Trejo
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain.
authors.forename: Marina
authors.initials: M
authors.lastname: Pollán
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), CIBERESP, Spain. Electronic address: bperez@isciii.es.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pérez-Gómez
mesh_terms: D000368:Aged; D001940:Breast / Q000000981:diagnostic imaging*; D000071060:Breast Density; D001943:Breast Neoplasms / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology
keywords: Breast cancer; Mammographic density; Sleep disorders; Sleep patterns