title: Oxidized Low Density Lipoprotein and High Sensitive C-Reactive Protein in Non-Diabetic, Pre-Diabetic and Diabetic Patients in the Acute Phase of the First Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention.
abstract: BACKGROUND
  Oxidized low density lipoprotein (ox-LDL) and high-sensitive C-reactive protein (hs-CRP) are elevated in diabetes mellitus (DM) and associated with accelerated atherosclerosis. Little is known about their dynamics in the acute phase of ST segment elevation myocardial infarction (STEMI), especially in relation to the presence of DM and pre-diabetes (pre-DM). This study aimed to analyze time-dependent changes in ox-LDL and hs-CRP regarding the presence of pre-DM and DM in STEMI patients treated by primary percutaneous coronary intervention (pPCI).
  
  
  METHODS
  In 103 consecutive patients with the first anterior STEMI ox-LDL and hs-CRP were measured before pPCI, on day 2 and day 7 after pPCI.
  
  
  RESULTS
  Patients were classified into: non-diabetics, pre-diabetics and diabetics. In each group the maximal ox-LDL concentration was found on admission, decreased on day 2 and reached the lowest values on day 7 (p<0.001). Diabetics had the highest ox-LDL concentrations compared to pre-diabetics and non-diabetics (on admission: p=0.028, on day 2: p=0.056, on day 7: p=0.004). hs-CRP concentration rose from admission, reached its peak on day 2 and decreased on day 7, in each group (p<0.001). Significant differences in hs-CRP concentrations were found between non-diabetics and pre-diabetics on admission (p=0.018) and day 2 (p=0.026). In a multivariate analysis DM was an independent determinant of high ox-LDL concentrations. Both ox-LDL and hs-CRP significantly correlated with Killip class, left ventricular ejection fraction, NT-proBNP and peak troponin I.
  
  
  CONCLUSIONS
  In patients with the first STEMI treated by pPCI there were significant differences in ox-LDL and hs-CRP concentrations between non-diabetics, pre-diabetics and diabetics. Ox-LDL and hs-CRP concentrations were related to heart failure parameters.
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Danijela
authors.initials: D
authors.lastname: Trifunović
authors.affiliation: Center for Medical Biochemistry, Clinical Centre of Serbia, School of Pharmacy, University of Belgrade, Serbia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Stanković
authors.affiliation: Institute of Medical Statistics and Informatics, School of Medicine, University of Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Marinković
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia.
authors.forename: Marko
authors.initials: M
authors.lastname: Banović
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia.
authors.forename: Nina
authors.initials: N
authors.lastname: Đukanović
authors.affiliation: Serbian Academy of Sciences and Arts, University of Belgrade, Serbia.
authors.forename: Olga
authors.initials: O
authors.lastname: Vasović
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Bosiljka
authors.initials: B
authors.lastname: Vujisić-Tešić
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Milan
authors.initials: M
authors.lastname: Petrović
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Stepanović
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Đorđević-Dikić
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Branko
authors.initials: B
authors.lastname: Beleslin
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Nedeljković
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia.
authors.forename: Milorad
authors.initials: M
authors.lastname: Tešić
authors.affiliation: Department of Cardiology, Clinical Centre of Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Ostojić
keywords: acute myocardial infarction; diabetes mellitus; high-sensitive C-reactive protein; oxidized LDL