title: Persistence of Nonceliac Wheat Sensitivity, Based on Long-term Follow-up.
abstract: We investigated how many patients with a diagnosis of nonceliac wheat sensitivity (NCWS) still experienced wheat sensitivity after a median follow-up time of 99 months. We collected data from 200 participants from a previous study of NCWS, performed between July and December 2016 in Italy; 148 of these individuals were still on a strict wheat-free diet. In total, 175 patients (88%) improved (had fewer symptoms) after a diagnosis of NCWS; 145 of 148 patients who adhered strictly to a gluten-free diet (98%) had reduced symptoms, compared with 30 of 52 patients who did not adhere to a gluten-free diet (58%) (P < .0001). Of the 22 patients who repeated the double-blind, placebo-controlled challenge, 20 reacted to wheat. We conclude that NCWS is a persistent condition. Clinicaltrials.gov registration number: NCT02823522.
authors.affiliation: Internal Medicine, Dipartimento di Biologia, Medicina Interna e Specialistica (Di.Bi.M.I.S.), University of Palermo, Palermo, Italy; Giovanni Paolo II Hospital, Sciacca, Italy. Electronic address: acarroccio@hotmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Carroccio
authors.affiliation: Division of Internal Medicine, Policlinico University Hospital, Palermo, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: D'Alcamo
authors.affiliation: Division of Pediatric Gastroenterology, "Di Cristina" Hospital, Palermo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Iacono
authors.affiliation: Division of Internal Medicine, Policlinico University Hospital, Palermo, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Soresi
authors.affiliation: Division of Internal Medicine, Policlinico University Hospital, Palermo, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Iacobucci
authors.affiliation: Division of Gastroenterology, Di.B.I.M.I.S., Policlinico University Hospital, Palermo, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Arini
authors.affiliation: Surgery Department, Policlinico University Hospital, Palermo, Italy.
authors.forename: Girolamo
authors.initials: G
authors.lastname: Geraci
authors.affiliation: Internal Medicine, Dipartimento di Biologia, Medicina Interna e Specialistica (Di.Bi.M.I.S.), University of Palermo, Palermo, Italy; Giovanni Paolo II Hospital, Sciacca, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Fayer
authors.affiliation: Division of Pediatrics, Sciacca, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cavataio
authors.affiliation: Division of Internal Medicine, Policlinico University Hospital, Palermo, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: La Blasca
authors.affiliation: Department of Pathology, Policlinico University Hospital, Palermo, Italy.
authors.forename: Ada M
authors.initials: AM
authors.lastname: Florena
authors.affiliation: Division of Internal Medicine, Policlinico University Hospital, Palermo, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Mansueto
mesh_terms: D000328:Adult; D002908:Chronic Disease; D055050:Diet, Gluten-Free; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D063189:Symptom Assessment; D021182:Wheat Hypersensitivity / Q000175:diagnosis* / Q000178:diet therapy*
keywords: Food Allergy; GFD; IBS; Outcome