title: Novel coronaviruses, astroviruses, adenoviruses and circoviruses in insectivorous bats from northern China.
abstract: Bats are considered as the reservoirs of several emerging infectious disease, and novel viruses are continually found in bats all around the world. Studies conducted in southern China found that bats carried a variety of viruses. However, few studies have been conducted on bats in northern China, which harbours a diversity of endemic insectivorous bats. It is important to understand the prevalence and diversity of viruses circulating in bats in northern China. In this study, a total of 145 insectivorous bats representing six species were collected from northern China and screened with degenerate primers for viruses belonging to six families, including coronaviruses, astroviruses, hantaviruses, paramyxoviruses, adenoviruses and circoviruses. Our study found that four of the viruses screened for were positive and the overall detection rates for astroviruses, coronaviruses, adenoviruses and circoviruses in bats were 21.4%, 15.9%, 20% and 37.2%, respectively. In addition, we found that bats in northern China harboured a diversity of novel viruses. Common Serotine (Eptesicus serotinu), Fringed long-footed Myotis (Myotis fimriatus) and Peking Myotis (Myotis pequinius) were investigated in China for the first time. Our study provided new information on the ecology and phylogeny of bat-borne viruses.
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Han
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: H-L
authors.initials: HL
authors.lastname: Wen
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhao
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: J-W
authors.initials: JW
authors.lastname: Liu
authors.affiliation: Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
authors.forename: L-M
authors.initials: LM
authors.lastname: Luo
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: C-M
authors.initials: CM
authors.lastname: Zhou
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: X-R
authors.initials: XR
authors.lastname: Qin
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: Y-L
authors.initials: YL
authors.lastname: Zhu
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: M-M
authors.initials: MM
authors.lastname: Liu
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: R
authors.initials: R
authors.lastname: Qi
authors.affiliation: School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: W-Q
authors.initials: WQ
authors.lastname: Li
authors.affiliation: Schools of Medicine, Fudan University, Shanghai, China.
authors.forename: H
authors.initials: H
authors.lastname: Yu
authors.affiliation: Wuhan University School of Health Sciences, Wuhan, Hubei, China.|Departments of Pathology and Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: X-J
authors.identifier: 0000-0003-2665-3811
authors.initials: XJ
authors.lastname: Yu
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000302:isolation & purification; D000818:Animals; D019200:Astroviridae / Q000235:genetics / Q000302:isolation & purification; D002681:China / Q000453:epidemiology; D002685:Chiroptera / Q000821:virology*; D018136:Circoviridae / Q000235:genetics / Q000302:isolation & purification; D003332:Coronaviridae / Q000235:genetics / Q000302:isolation & purification; D010802:Phylogeny; D014780:Viruses / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*
keywords: China; adenoviruses; astroviruses; bats; circoviruses; coronaviruses