title: Antibacterial Compounds from Marine Bacteria, 2010-2015.
abstract: This review summarizes the reports on antibacterial compounds that have been obtained from marine-derived bacteria during the period 2010-2015. Over 50 active compounds were isolated during this period, most of which (69%) were obtained from Actinobacteria. Several compounds were already known, such as etamycin A (11) and nosiheptide (65), and new experiments with them showed some previously undetected antibacterial activities, highlighting the fact that known natural products may be an important source of new antibacterial leads. New broad-spectrum antibacterial compounds were reported with activity against antibiotic resistant Gram-positive and Gram-negative bacteria. Anthracimycin (33), kocurin (66), gageotetrins A-C (72-74), and gageomacrolactins 1-3 (86-88) are examples of compounds that display promising properties and could be leads to new antibiotics. A number of microbes produced mixtures of metabolites sharing similar chemical scaffolds, and structure-activity relationships are discussed.
authors.affiliation: Department of Food Science, School of Food Engineering, University of Campinas , Campinas-SP, CEP 13083-862, Brazil.
authors.forename: Claudia
authors.identifier: 0000-0001-7890-1464
authors.initials: C
authors.lastname: Schinke
authors.affiliation: Department of Food Science, School of Food Engineering, University of Campinas , Campinas-SP, CEP 13083-862, Brazil.
authors.forename: Thamires
authors.identifier: 0000-0002-3418-902X
authors.initials: T
authors.lastname: Martins
authors.affiliation: Brazilian Agricultural Research Corporation , Rodovia SP-340 km 127.5, Jaguariúna-SP, CEP 13820-000, Brazil.
authors.forename: Sonia C N
authors.identifier: 0000-0002-1725-183X
authors.initials: SCN
authors.lastname: Queiroz
authors.affiliation: Brazilian Agricultural Research Corporation , Rodovia SP-340 km 127.5, Jaguariúna-SP, CEP 13820-000, Brazil.
authors.forename: Itamar S
authors.identifier: 0000-0003-2785-6725
authors.initials: IS
authors.lastname: Melo
authors.affiliation: Department of Food Science, School of Food Engineering, University of Campinas , Campinas-SP, CEP 13083-862, Brazil.
authors.forename: Felix G R
authors.identifier: 0000-0003-0126-3817
authors.initials: FGR
authors.lastname: Reyes
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D047630:Depsipeptides
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C004910:etamycin; D047630:Depsipeptides