title: MicroRNA: an important regulator in acute myeloid leukemia.
abstract: MicroRNAs (miRNAs) are a general class of endogenous non-coding RNAs with a length of 22 nucleotides, widely existing in diverse species and playing important roles in malignancies initiation and progression. MiRNAs are essential to many in vivo biological processes such as cell proliferation, apoptosis, immune response, and tumorigenesis. Significant progress till date has been made in understanding the roles of microRNAs in normal hematopoiesis and hematopoietic malignant diseases. In this review, we summarize the particular signatures of microRNAs in acute myeloid leukemia (AML) patients with specific karyotype and the clinical significance of microRNAs in early diagnosis and treatment. MicroRNAs hypermethylation was also proved to correlate with the pathogenesis of AML. However, the target genes and exact pathways of microRNAs participating in these processes are still unknown and more efforts need to be made in the near future.
authors.affiliation: Department of Clinical Hematology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi Province 710004, P.R. China.
authors.forename: Xiaman
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Clinical Hematology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi Province 710004, P.R. China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Clinical Hematology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi Province 710004, P.R. China.
authors.forename: Ju
authors.initials: J
authors.lastname: Bai
authors.affiliation: Department of Clinical Hematology, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi Province 710004, P.R. China.|National-Local Joint Engineering Research Center of Biodiagnostics and Biotherapy, Xi'an, P.R. China.
authors.forename: Aili
authors.initials: A
authors.lastname: He
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D020869:Gene Expression Profiling / Q000379:methods; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism*; D008745:Methylation; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional
chemical_list: D035683:MicroRNAs
keywords: AML; hypermethylation; leukemogenesis; microRNA; ncRNA; target genes