title: A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout.
abstract: For the assessment of small airway diseases, a noninvasive double-tracer gas single-breath washout (DTG-SBW) with sulfur hexafluoride (SF6) and helium (He) as tracer components has been proposed. It is assumed that small airway diseases may produce typical ventilation inhomogeneities which can be detected within one single tidal breath, when using two tracer components. Characteristic parameters calculated from a relative molar mass (MM) signal of the airflow during the washout expiration phase are analyzed. The DTG-SBW signal is acquired by subtracting a reconstructed MM signal without tracer gas from the signal measured with an ultrasonic sensor during in- and exhalation of the double-tracer gas for one tidal breath. In this paper, a simple method to determine the reconstructed MM signal is presented. Measurements on subjects with and without obstructive lung diseases including the small airways have shown high reliability and reproducibility of this method.
authors.affiliation: Institut für Biomedizinische Technik, Universität Stuttgart, Stuttgart, Germany. jp@bmt.uni-stuttgart.de.
authors.forename: Johannes
authors.identifier: http://orcid.org/0000-0001-7091-9520
authors.initials: J
authors.lastname: Port
authors.affiliation: Institut für Biomedizinische Technik, Universität Stuttgart, Stuttgart, Germany.
authors.forename: Ziran
authors.initials: Z
authors.lastname: Tao
authors.affiliation: Institut für Biomedizinische Technik, Universität Stuttgart, Stuttgart, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Junger
authors.affiliation: Institut für Biomedizinische Technik, Universität Stuttgart, Stuttgart, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Joppek
authors.affiliation: Institut für Biomedizinische Technik, Universität Stuttgart, Stuttgart, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Tempel
authors.affiliation: Klinik Schillerhöhe, Zentrum für Pneumologie und Thoraxchirurgie, Robert-Bosch-Hospital, Gerlingen, Germany.|Internistische Facharztpraxis für Pneumologie, Allergologie, Thoraxonkologie, Bronchoskopie und Schlafmedizin, MVZ Klinikum Kempten GmbH, Kempten, Germany.
authors.forename: Kim
authors.initials: K
authors.lastname: Husemann
authors.affiliation: University Children's Hospital Zurich, Zurich, Switzerland.
authors.forename: Florian
authors.initials: F
authors.lastname: Singer
authors.affiliation: University Children's Hospital Basel, Basel, Switzerland.
authors.forename: Philipp
authors.initials: P
authors.lastname: Latzin
authors.affiliation: University Children's Hospital Basel, Basel, Switzerland.
authors.forename: Sophie
authors.initials: S
authors.lastname: Yammine
authors.affiliation: Institut für Biomedizinische Technik, Universität Stuttgart, Stuttgart, Germany.
authors.forename: Joachim H
authors.initials: JH
authors.lastname: Nagel
authors.affiliation: Klinik Schillerhöhe, Zentrum für Pneumologie und Thoraxchirurgie, Robert-Bosch-Hospital, Gerlingen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Kohlhäufl
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000175:diagnosis* / Q000378:metabolism; D002648:Child; D006371:Helium / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000378:metabolism; D012123:Pulmonary Ventilation / Q000502:physiology*; D015203:Reproducibility of Results; D012119:Respiration; D013459:Sulfur Hexafluoride / Q000378:metabolism; D013990:Tidal Volume / Q000502:physiology
chemical_list: D006371:Helium; D013459:Sulfur Hexafluoride
keywords: Double-tracer gas single-breath washout (DTG-SBW); OLS; Signal reconstruction; Small airway diseases