title: The Healthy Brain Network Serial Scanning Initiative: a resource for evaluating inter-individual differences and their reliabilities across scan conditions and sessions.
abstract: Although typically measured during the resting state, a growing literature is illustrating the ability to map intrinsic connectivity with functional MRI during task and naturalistic viewing conditions. These paradigms are drawing excitement due to their greater tolerability in clinical and developing populations and because they enable a wider range of analyses (e.g., inter-subject correlations). To be clinically useful, the test-retest reliability of connectivity measured during these paradigms needs to be established. This resource provides data for evaluating test-retest reliability for full-brain connectivity patterns detected during each of four scan conditions that differ with respect to level of engagement (rest, abstract animations, movie clips, flanker task). Data are provided for 13 participants, each scanned in 12 sessions with 10 minutes for each scan of the four conditions. Diffusion kurtosis imaging data was also obtained at each session.
  
  
  
  Technical validation and demonstrative reliability analyses were carried out at the connection-level using the Intraclass Correlation Coefficient and at network-level representations of the data using the Image Intraclass Correlation Coefficient. Variation in intrinsic functional connectivity across sessions was generally found to be greater than that attributable to scan condition. Between-condition reliability was generally high, particularly for the frontoparietal and default networks. Between-session reliabilities obtained separately for the different scan conditions were comparable, though notably lower than between-condition reliabilities.
  
  
  
  This resource provides a test-bed for quantifying the reliability of connectivity indices across subjects, conditions and time. The resource can be used to compare and optimize different frameworks for measuring connectivity and data collection parameters such as scan length. Additionally, investigators can explore the unique perspectives of the brain's functional architecture offered by each of the scan conditions.
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.|Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY.
authors.forename: David
authors.initials: D
authors.lastname: O'Connor
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.
authors.forename: Natan Vega
authors.initials: NV
authors.lastname: Potler
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.
authors.forename: Meagan
authors.initials: M
authors.lastname: Kovacs
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.
authors.forename: Lei
authors.initials: L
authors.lastname: Ai
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.|Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY.
authors.forename: John
authors.initials: J
authors.lastname: Pellman
authors.affiliation: Yale University, New Haven, CT.
authors.forename: Tamara
authors.initials: T
authors.lastname: Vanderwal
authors.affiliation: City College of New York, New York, NY.
authors.forename: Lucas C
authors.initials: LC
authors.lastname: Parra
authors.affiliation: The Graduate Center of the City University of New York, New York, NY.
authors.forename: Samantha
authors.initials: S
authors.lastname: Cohen
authors.affiliation: Massachusetts Institute of Technology, Cambridge, MA.
authors.forename: Satrajit
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.
authors.forename: Jasmine
authors.initials: J
authors.lastname: Escalera
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.
authors.forename: Natalie
authors.initials: N
authors.lastname: Grant-Villegas
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.
authors.forename: Yael
authors.initials: Y
authors.lastname: Osman
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Bui
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.|Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY.
authors.forename: R Cameron
authors.initials: RC
authors.lastname: Craddock
authors.affiliation: Center for the Developing Brain, Child Mind Institute, New York, NY.|Center for Biomedical Imaging and Neuromodulation, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Milham
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D016000:Cluster Analysis; D063132:Connectome / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D007206:Individuality; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012984:Software; D011795:Surveys and Questionnaires; D064878:Web Browser; D055815:Young Adult
keywords: Data sharing; Reliability; fMRI