title: Current Treatment Strategies for Intracranial Aneurysms: An Overview.
abstract: Intracranial aneurysm is a leading cause of stroke. Its treatment has evolved over the past 2 decades. This review summarizes the treatment strategies for intracranial aneurysms from 3 different perspectives: open surgery approach, transluminal treatment approach, and new technologies being used or trialed. We introduce most of the available treatment techniques in detail, including contralateral clipping, wrapping and clipping, double catheters assisting coiling and waffle-cone technique, and so on. Data from major trials such as Analysis of Treatment by Endovascular approach of Non-ruptured Aneurysms (ATENA), Internal Subarachnoid Trial (ISAT), Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms (CLARITY), and Barrow Ruptured Aneurysm Trial (BRAT) as well as information from other clinical reports and local experience are reviewed to suggest a clinical pathway for treating different types of intracranial aneurysms. It will be a valuable supplement to the current existing guidelines. We hope it could help assisting real-time decision-making in clinical practices and also encourage advancements in managing the disease.
authors.affiliation: 1 Division of Surgery & Interventional Science, UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, United Kingdom.|Authors equally contributed to this manuscript.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhao
authors.affiliation: 2 Guangdong Provincial Hospital of TCM, Guangzhou, People's Republic of China.|Authors equally contributed to this manuscript.
authors.forename: Hao
authors.initials: H
authors.lastname: Lin
authors.affiliation: 3 Swansea University, Wales, United Kingdom.
authors.forename: Richard
authors.initials: R
authors.lastname: Summers
authors.affiliation: 4 Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, United Kingdom.
authors.forename: Mingmin
authors.initials: M
authors.lastname: Yang
authors.affiliation: 1 Division of Surgery & Interventional Science, UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, United Kingdom.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Cousins
authors.affiliation: 1 Division of Surgery & Interventional Science, UCL Centre for Nanotechnology and Regenerative Medicine, University College London, London, United Kingdom.|5 Royal Free London NHS Foundation Trust Hospital, London, United Kingdom.
authors.forename: Janice
authors.initials: J
authors.lastname: Tsui
mesh_terms: D017542:Aneurysm, Ruptured / Q000628:therapy*; D002548:Cerebral Revascularization / Q000379:methods; D004621:Embolization, Therapeutic / Q000379:methods; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D012008:Recurrence; D016896:Treatment Outcome
keywords: angiography; cerebral revascularization; intracranial aneurysm; intracranial vasospasm; stenting; stroke