title: The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone.
abstract: The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome (MetS) and neurodegenerative diseases (NDD) like Alzheimer's disease, Huntington's disease, Parkinson's disease and depression. If one factor plays an essential role in the pathogenesis of two diseases, it can be concluded that there might be a common root in these two diseases, as well. This review was aimed to highlight the crucial roles of BDNF in the pathogenesis of MetS and NDD and to introduce sole prophylactic or therapeutic applications, BDNF gene therapy and BDFN administration, in controlling MetS and NDD.
authors.affiliation: Graduate of Doctor of Veterinary Medicine, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Motamedi
authors.affiliation: Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran. karimiisaac@razi.ac.ir.
authors.forename: Isaac
authors.identifier: http://orcid.org/0000-0001-7415-0472
authors.initials: I
authors.lastname: Karimi
authors.affiliation: Young Researchers and Elite Club, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Jafari
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000378:metabolism / Q000523:psychology; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology / Q000378:metabolism / Q000523:psychology; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism* / Q000523:psychology; D019636:Neurodegenerative Diseases / Q000453:epidemiology* / Q000378:metabolism* / Q000523:psychology; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism / Q000523:psychology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: BDNF; Depression; Metabolic syndrome; Neurodegenerative diseases; Obesity