title: Antithrombotic Activity of DAB-15, a Novel Diazepinobenzimidazole Compound.
abstract: Antithrombotic activity of a new orally administered antiplatelet compound DAB-15 was compared to that of acetylsalicylic acid, ticlopidine, and clopidogrel in the experimental model of arterial thrombosis in rats caused by surface application of 50% ferric chloride (III) on the carotid artery. Compound DAB-15 exerted a dose-dependent antithrombotic effect and was superior to acetylsalicylic acid, ticlopidine and clopidogrel by 5, 7, and 4.9 times, respectively (by ED50). This necessitates studying of the action mechanism of this antiplatelet compound with consideration of its influence on different stages of the pathogenesis of platelet aggregation.
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. aidakucheryavenko@yandex.ru.
authors.forename: A F
authors.initials: AF
authors.lastname: Kucheryavenko
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: V S
authors.initials: VS
authors.lastname: Sirotenko
authors.affiliation: Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
authors.forename: K A
authors.initials: KA
authors.lastname: Gaidukova
authors.affiliation: Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Morkovnik
authors.affiliation: Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
authors.affiliation: Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
authors.forename: L N
authors.initials: LN
authors.lastname: Divaeva
authors.affiliation: Research Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Kuz'menko
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage; D001381:Azepines / Q000008:administration & dosage*; D001562:Benzimidazoles / Q000008:administration & dosage*; D002341:Carotid Artery Thrombosis / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D013988:Ticlopidine / Q000008:administration & dosage
chemical_list: D001381:Azepines; D001562:Benzimidazoles; D005343:Fibrinolytic Agents; D013988:Ticlopidine; D001241:Aspirin
keywords: acetylsalicylic acid; antithrombotic activity; clopidogrel; compound DAB-15; ticlopidine