title: New Acorane-Type Sesquiterpene from Acorus calamus L.
abstract: A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts ofAcorus calamusL. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds1and2are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds1(10 μM),2(5 μM and 10 μM) and3(10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line.
authors.affiliation: Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. forever_lijuan@163.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: National Center for Natural Products Research, University of Mississippi, University MS 38677, USA. zjianping@hotmail.com.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. wangwei402@hotmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing 100053, China. linli97@hotmail.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.affiliation: Key Laboratory of Neurodegenerative Diseases of Ministry of Education, Capital Medical University, Beijing 100053, China. lanizhg@hotmail.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. woshizxiaof@sina.com.
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Zhao
authors.affiliation: Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. lqr199106@hotmail.com.
authors.forename: Qing-Ru
authors.initials: QR
authors.lastname: Liu
authors.affiliation: Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. fliu0825@126.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ymn77@163.com.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: National Center for Natural Products Research, University of Mississippi, University MS 38677, USA. ikhan@olemiss.edu.
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.affiliation: Hunan Province Engineering Research Center of Bioactive Substance Discovery of TCM, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. lishunxiang@hotmail.com.
authors.forename: Shun-Xiang
authors.initials: SX
authors.lastname: Li
mesh_terms: D029023:Acorus / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation; D018360:Crystallography, X-Ray; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D012717:Sesquiterpenes
keywords: Acorus calamus L.; Araceae; acorane-type sesquiterpene; biosynthetic pathway; cell proliferation