title: Characteristics of Depressive-Like Behavior of Prenatally Stressed Male Rats with Androgen Deficiency.
abstract: Characteristics of depressive-like behavior of male rats with androgen deficiency born by mothers subjected to prenatal stress during pregnancy were assessed by using Porsolt tests and open-field tests. The level of depression-like behavior in prenatally stressed males increased more intensively than in non-stressed gonadectomized males. Chronic administration of testosterone propionate (0.5 mg/kg, intramuscularly, for 14 days) increased depressive behavior in prenatally stressed gonadectomized males in contrast to its antidepressant effect in nonstressed gonadectomized rats. Prenatal stress considerably exacerbated depressive behavior of male rats under conditions of androgen deficiency and abolished the antidepressant effect of exogenously administered testosterone propionate.
authors.affiliation: Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. julia.fedotova@mail.ru.
authors.forename: Yu O
authors.initials: YO
authors.lastname: Fedotova
authors.affiliation: Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: V K
authors.initials: VK
authors.lastname: Akulova
authors.affiliation: Laboratory of Neuroendocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: S G
authors.initials: SG
authors.lastname: Pivina
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage; D003863:Depression / Q000097:blood* / Q000209:etiology; D005260:Female; D007273:Injections, Intramuscular; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood* / Q000209:etiology; D051381:Rats; D013315:Stress, Psychological / Q000097:blood / Q000150:complications*; D013739:Testosterone / Q000008:administration & dosage / Q000172:deficiency*
chemical_list: D000928:Antidepressive Agents; D013739:Testosterone
keywords: androgens; behavior; depression; gonadectomy; prenatal stress