title: Pupillary response to cognitive workload during saccadic tasks in Parkinson's disease.
abstract: The relationship between cognitive workload and cognitive impairments in Parkinson's disease (PD) is currently not well known. This study compared cognitive workload during saccadic tasks between patients with PD and controls. Sixteen controls, 11 patients with no obvious cognitive impairment (PD-NCI) (MOCA score≥26), and 10 PD patients with cognitive impairment (PD-CI) (MOCA score<26) performed prosaccade and antisaccade tasks. Cognitive workload, extracted via pupil recording, and other eye metrics were compared between the three groups. PD-NCI patients exhibited greater cognitive workload than controls in the prosaccade task. PD-CI patients also showed more cognitive workload in the prosaccade task than PD-NCI patients and controls. No other differences in eye metrics were found between the three groups. Cognitive workload could be used to differentiate between different cognitive states in PD. The causal relationship between increased cognitive workload and cognitive decline in PD-NCI should be the focus of future studies.
authors.affiliation: Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; University of Lyon, F-69000 Lyon, France; French Institute of Science and Technology for Transport, Development and Networks (IFSTTAR), TS2, LESCOT, F-69500 Bron, France. Electronic address: maud.ranchet@ifsttar.fr.
authors.forename: M
authors.initials: M
authors.lastname: Ranchet
authors.affiliation: Cybermedia Center, Toyonaka Educational Research Center 5F, Osaka University, 1-32 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Orlosky
authors.affiliation: Movement and Cognitive Disorders Center, Department of Neurology, Augusta University, GA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Morgan
authors.affiliation: Medical College of Georgia, Augusta University, GA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Qadir
authors.affiliation: Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; Dean's Office, School of Health Professions, The University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Akinwuntan
authors.affiliation: Department of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA, USA; Department of Physical Therapy and Rehabilitation Science, School of Health Professions, The University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: H
authors.initials: H
authors.lastname: Devos
mesh_terms: D000368:Aged; D003071:Cognition; D060825:Cognitive Dysfunction / Q000209:etiology / Q000503:physiopathology; D053483:Eye Movement Measurements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology*; D010775:Photic Stimulation; D011680:Pupil / Q000502:physiology; D012438:Saccades / Q000502:physiology
keywords: Antisaccade task; Cognitive workload; Executive function; Parkinson’s disease; Prosaccade task