title: Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons.
abstract: Neuronal communication and brain function mainly depend on the fundamental biological events of neurotransmission, including the exocytosis of presynaptic vesicles (SVs) for neurotransmitter release and the subsequent endocytosis for SV retrieval. Neurotransmitters are released through the Ca2+- and SNARE-dependent fusion of SVs with the presynaptic plasma membrane. Following exocytosis, endocytosis occurs immediately to retrieve SV membrane and fusion machinery for local recycling and thus maintain the homeostasis of synaptic structure and sustained neurotransmission. Apart from the general endocytic machinery, recent studies have also revealed the involvement of SNARE proteins (synaptobrevin, SNAP25 and syntaxin), synaptophysin, Ca2+/calmodulin, and members of the synaptotagmin protein family (Syt1, Syt4, Syt7 and Syt11) in the balance and tight coupling of exo-endocytosis in neurons. Here, we provide an overview of recent progress in understanding how these neuron-specific adaptors coordinate to ensure precise and efficient endocytosis during neurotransmission.
authors.affiliation: Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong UniversityXi'an, China; Frontier Institute of Science and Technology, Xi'an Jiaotong UniversityXi'an, China; State Key Laboratory of Membrane Biology, Peking UniversityBeijing, China; Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking UniversityBeijing, China.
authors.forename: Zhenli
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong UniversityXi'an, China; Frontier Institute of Science and Technology, Xi'an Jiaotong UniversityXi'an, China.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Long
authors.affiliation: Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong UniversityXi'an, China; Frontier Institute of Science and Technology, Xi'an Jiaotong UniversityXi'an, China.
authors.forename: Jiankang
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Membrane Biology, Peking UniversityBeijing, China; Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking UniversityBeijing, China.
authors.forename: Zuying
authors.initials: Z
authors.lastname: Chai
authors.affiliation: State Key Laboratory of Membrane Biology, Peking UniversityBeijing, China; Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking UniversityBeijing, China; College of Life Sciences, Liaocheng UniversityLiaocheng, China; Key Laboratory of Medical Electrophysiology, Ministry of Education of China, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical UniversityLuzhou, China.
authors.forename: Xinjiang
authors.initials: X
authors.lastname: Kang
authors.affiliation: Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong UniversityXi'an, China; Frontier Institute of Science and Technology, Xi'an Jiaotong UniversityXi'an, China; State Key Laboratory of Membrane Biology, Peking UniversityBeijing, China; Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking UniversityBeijing, China.
authors.forename: Changhe
authors.initials: C
authors.lastname: Wang
keywords: SNARE; calmodulin; endocytosis; exocytosis; synaptotagmin; vesicle recycling