title: Potential drug targets and treatment of schizophrenia.
abstract: Schizophrenia is one of the most prevalent chronic psychiatric disorders that affect 1% of the world's population. Despite its societal burden, pathophysiology of schizophrenia remains poorly understood. Currently available drugs predominantly control positive symptoms, and often have no or poor control on negative and related cognitive symptoms, which strongly affect functional outcome in schizophrenia. The present article is an attempt to provide a critical review of recent hypothesis to understand pathophysiology of schizophrenia and to highlight exploitable molecular drug targets other than dopaminergic systems to treat and manage schizophrenia effectively.
authors.affiliation: Neuropharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh, 160014, India. kumaruips@yahoo.com.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, India.
authors.forename: Monu
authors.initials: M
authors.lastname: Yadav
authors.affiliation: Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, 125001, India.
authors.forename: Milind
authors.initials: M
authors.lastname: Parle
authors.affiliation: Faculty of Medical Sciences, School of Pharmacy, The University of the West Indies, St. Augustine, Trinidad and Tobago.
authors.forename: Sameer
authors.initials: S
authors.lastname: Dhingra
authors.affiliation: Neuropharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies (UGC-CAS), Panjab University, Chandigarh, 160014, India.
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Dhull
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D009422:Nervous System Diseases / Q000188:drug therapy; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D004364:Pharmaceutical Preparations
keywords: Antipsychotics; Negative symptoms; Neurochemical; Oxidative stress; Schizophrenia