title: Characterization of Leiomyomatoid Angiomatous Neuroendocrine Tumour (LANT)-like Tumour in the Myometrium with Histopathological Examination.
abstract: Leiomyomatoid angiomatous neuroendocrine tumour (LANT) is possibly a new disease entity that was reported as a dimorphic neurosecretory tumour with a leiomyomatous vascular component; it was found in the pituitary. We describe uterine LANT-like malignant tumour in a 45-year-old woman with uterine mesenchymal tumour, diagnosed clinically as uterine leiomyoma. She underwent laparoscopic myomectomy. The tumour consisted of hyalinized vasculature, containing factor VIII-positive endothelium and α-smooth muscle actin-positive vascular smooth muscle cells, and stromal cells, expressing neuroadhesion molecules. Both vascular and stromal components diffusely expressed chromogranin A. Histopathological examinations of uterine LANT-like malignant tumour revealed the common characteristic abnormalities of malignant uterine mesenchymal tumours, i.e. leiomyosarcomas. From our research, defective expression of calponin H1 and proteasome β9 (PSMB9)/β1i is observed in uterine LANT-like malignant tumour similarly to immunopathological findings of uterine leiomyosarcoma. These findings meet the definition of uterine LANT-like malignant tumour, and the research findings of our clinical case suggest that LANT is a special type of neuroendocrine neoplasm and is not organ specific.
authors.affiliation: Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Nagano, Japan yoyoyo224@hotmail.com.
authors.forename: Takuma
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ichimura
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Kasai
authors.affiliation: Department of Medical Laboratory, Shinshu University Hospital, Nagano, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sano
authors.affiliation: SIGMA-Aldrich Israel, Rehovot, Israel.
authors.forename: Dorit
authors.initials: D
authors.lastname: Zharhary
authors.affiliation: Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Tanri
authors.initials: T
authors.lastname: Shiozawa
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Miyagi, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.affiliation: National Hospital Organization Kyoto Medical Centre, Kyoto, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Konishi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007889:Leiomyoma / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009215:Myometrium / Q000378:metabolism / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: C071313:LMP-2 protein; D003546:Cysteine Endopeptidases
keywords: LANT; PSMB9; calponin H1; leiomyosarcoma; mesenchymal tumour