title: Economic impact of ovarian stimulation with corifollitropin alfa versus conventional daily gonadotropins in oocyte donors: a randomized study.
abstract: Assisted reproductive technologies are well-established treatments for many types of subfertility representing substantial economic and healthcare implications for patients, healthcare providers and society as a whole. In order to optimize outcomes according to the type of gonadotrophins within an oocyte donor programme, we performed an economic evaluation based on data collected in a multicentre, prospective, randomized study within three private clinics belonging to the IVI Group. Results showed no relevant between-group differences in the clinical variables. According to the economic analysis, ovarian stimulation with corifollitropin alfa increased the overall cost of the treatment as well as the cost per retrieved and effective oocyte, although the differences were not statistically significant. In conclusion, cost savings can be achieved using cheaper gonadotrophins during ovarian stimulation. The cost of corifollitropin alfa compared with recombinant FSH and highly purified human menopausal gonadotrophin should be considered when making treatment decisions.
authors.affiliation: Reproductive Medicine Department, Instituto Valenciano de Infertilidad IVI Madrid, Avenida del Talgo 68-70, Aravaca, 28023 Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Cruz
authors.affiliation: Reproductive Medicine Department, Instituto Valenciano de Infertilidad IVI Valencia, Plaza de la Policía Local 3, 46015 Valencia, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Alamá
authors.affiliation: Reproductive Medicine Department, Instituto Valenciano de Infertilidad IVI Alicante, Avenida de Denia 111, 03015 Alicante, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Muñoz
authors.affiliation: Reproductive Medicine Department, Instituto Valenciano de Infertilidad IVI Madrid, Avenida del Talgo 68-70, Aravaca, 28023 Madrid, Spain.
authors.forename: Diana
authors.initials: D
authors.lastname: Collado
authors.affiliation: Reproductive Medicine Department, Instituto Valenciano de Infertilidad IVI Valencia, Plaza de la Policía Local 3, 46015 Valencia, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Blanes
authors.affiliation: Reproductive Medicine Department, Instituto Valenciano de Infertilidad IVI Valencia, Plaza de la Policía Local 3, 46015 Valencia, Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Solbes
authors.affiliation: Reproductive Medicine Department, Instituto Valenciano de Infertilidad IVI Madrid, Avenida del Talgo 68-70, Aravaca, 28023 Madrid, Spain. Electronic address: antonio.requena@ivi.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Requena
mesh_terms: D000328:Adult; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000008:administration & dosage* / Q000191:economics; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage* / Q000191:economics; D018587:Oocyte Donation; D010062:Ovulation Induction / Q000191:economics / Q000379:methods*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000191:economics; D055815:Young Adult
chemical_list: D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; C437186:follicle stimulating hormone, human, with HCG C-terminal peptide; C571802:follitropin beta; D008596:Menotropins
keywords: Corifollitropin alfa; Cost savings; Cost-effectiveness; Egg donor programme