title: Periconceptional folic acid supplementation and vitamin B12status in a cohort of Chinese early pregnancy women with the risk of adverse pregnancy outcomes.
abstract: Maternal folate and vitamin B12deficiency predict poor pregnancy outcome. To improve pregnancy outcomes in rural area of China, we investigate rural women's folic acid supplementation (FAS) status and the associations between maternal vitamin B status during the first trimester and subsequent adverse pregnancy outcomes. We collected the questionnaire information and drew 5 ml of blood from 309 early pregnant rural women. The birth outcomes were retrieved from medical records after delivery. Out of the total, 257 had taken FAS, including 50 before conception (group A) and 207 during the first trimester (group B). The concentration of plasma folate and the RBC folate supplementation groups were obviously higher than that of no-supplementation group (group N,p<0.01). The mean vitamin B12levels in FAS group were significantly higher than those in groups N and B (p<0.05). Women who delivered SGA or premature infants had reduced plasma folate levels (p<0.05) compared with controls. The multiple linear regression models revealed that RBC folate levels affected the infant birth weight (p<0.01) and birth length (p<0.05). In conclusion, FAS can significantly improve plasma folate and RBC folate levels in childbearing-age women and reduce the risk of subsequent adverse pregnancy outcomes.
authors.affiliation: Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wei
authors.affiliation: Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liang
authors.affiliation: Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
authors.forename: Youxue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Capital Institute of Pediatrics, No. 2 Yabao Er Rd, Chaoyang District, Beijing 100020, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
authors.forename: Tingyu
authors.initials: T
authors.lastname: Li
keywords: adverse pregnancy outcomes; early pregnancy; folate; newborn; vitamin B12