title: Assembly of Iron Oxide Nanocubes for Enhanced Cancer Hyperthermia and Magnetic Resonance Imaging.
abstract: Multiple formulations of iron oxide nanoparticles (IONPs) have been proposed for enhancing contrast in magnetic resonance imaging (MRI) and for increasing efficacy in thermal ablation therapies. However, insufficient accumulation at the disease site and low magnetic performance hamper the clinical application of IONPs. Here, 20 nm iron oxide nanocubes were assembled into larger nanoconstructs externally stabilized by a serum albumin coating. The resulting assemblies of nanocubes (ANCs) had an average diameter of 100 nm and exhibited transverse relaxivity (r₂ = 678.9 ± 29.0 mM‒1·s‒1at 1.41 T) and heating efficiency (specific absorption rate of 109.8 ± 12.8 W·g‒1at 512 kHz and 10 kA·m‒1). In mice bearing glioblastoma multiforme tumors, Cy5.5-labeled ANCs allowed visualization of malignant masses via both near infrared fluorescent and magnetic resonance imaging. Also, upon systemic administration of ANCs (5 mgFe·kg‒1), 30 min of daily exposure to alternating magnetic fields for three consecutive days was sufficient to halt tumor progression. This study demonstrates that intravascular administration of ANCs can effectively visualize and treat neoplastic masses.
authors.affiliation: Department of Translational Imaging & Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA. supia1001@gmail.com.|Department of Chemistry, Rice University, Houston, TX 77005, USA. supia1001@gmail.com.
authors.forename: Minjung
authors.initials: M
authors.lastname: Cho
authors.affiliation: Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy. Antonio.Cervadoro@iit.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cervadoro
authors.affiliation: Department of Translational Imaging & Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA. MReyes2@houstonmethodist.org.
authors.forename: Maricela R
authors.initials: MR
authors.lastname: Ramirez
authors.affiliation: Department of Translational Imaging & Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA. cinzia.stigliano@gmail.com.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Stigliano
authors.affiliation: Department of Physics and Texas Center for Superconductivity, University of Houston, Houston, TX 77004, USA. audrius@uh.edu.
authors.forename: Audrius
authors.initials: A
authors.lastname: Brazdeikis
authors.affiliation: Department of Chemistry, Rice University, Houston, TX 77005, USA. vicki_colvin@brown.edu.
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Colvin
authors.affiliation: Dipartimento di Elettronica e Telecomunicazioni, Politecnico di Torino, I-10129 Torino, Italy. keyjae@gmail.com.|Pierluigi Civera died on 28 October 2014.. keyjae@gmail.com.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Civera
authors.affiliation: Department of Biomedical Engineering, Yonsei University, 1 Yonseidae-gil, Wonju, Gangwon-do 220-710, Korea. jkey@yonsei.ac.kr.
authors.forename: Jaehong
authors.initials: J
authors.lastname: Key
authors.affiliation: Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia, 16163 Genova, Italy. Paolo.Decuzzi@iit.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Decuzzi
keywords: cancer theranostics; magnetic dragging; magnetic resonance imaging; nanomedicine; specific absorption rate