title: Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report.
abstract: Paroxysmal cold hemoglobinuria (PCH) is a form of autoimmune hemolytic anemia caused by the Donath-Landsteiner antibody (D-L antibody). In children, this is typically a transient immune-mediated hemolysis that follows a viral illness and does not recur. Recurrent acute or chronic PCH due to D-L antibody is very rare.
  
  
  
  We have reported a unique case of recurrent PCH in a 5-year-old boy with two acute episodes of hemolysis separated by 21 months of hematologic remission. Each episode was severe requiring red blood cell transfusions, intravenous methylprednisolone, and intravenous immunoglobulin during the second episode. Testing identified recurrence of the D-L antibody with the classic anti-P biphasic hemolysis.
  
  
  
  This demonstrates that PCH can be a recurrent disease in the pediatric population (in the absence of syphilis) with the classical D-L antibody.
authors.affiliation: Nemours Alfred I. DuPont Hospital for Children, Wilmington, Delaware.
authors.forename: Sara D
authors.initials: SD
authors.lastname: Prince
authors.affiliation: Division of Pediatric Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Lena E
authors.initials: LE
authors.lastname: Winestone
authors.affiliation: Immunohematology Reference Laboratories, American Red Cross, Philadelphia, Pennsylvania.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Nance
authors.affiliation: Division of Pediatric Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: David F
authors.initials: DF
authors.lastname: Friedman
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D007136:Immunoglobulins; D008775:Methylprednisolone