title: Whole-Cell Recording in the Awake Brain.
abstract: Intracellular recording is an essential technique for investigating cellular mechanisms underlying complex brain functions. Despite the high sensitivity of the technique to mechanical disturbances, intracellular recording has been applied to awake, behaving, and even freely moving, animals. Here we summarize recent advances in these methods and their application to the measurement and manipulation of membrane potential dynamics for understanding neuronal computations in behaving animals.
authors.affiliation: Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34141, Republic of Korea; leedoyun@ibs.re.kr leea@janelia.hhmi.org.
authors.forename: Doyun
authors.initials: D
authors.lastname: Lee
authors.affiliation: Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia 20147 leedoyun@ibs.re.kr leea@janelia.hhmi.org.
authors.forename: Albert K
authors.initials: AK
authors.lastname: Lee
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D008564:Membrane Potentials; D018408:Patch-Clamp Techniques / Q000379:methods*