title: Transgenic rescue of Atg5-null mice from neonatal lethality with neuron-specific expression of ATG5: Systemic analysis of adult Atg5-deficient mice.
abstract: Atg5-null mice are neonatal lethal. We have revealed in our recent paper that these mice die due to neuronal dysfunction resulting in suckling failure. Our new mouse model, atg5-/-;Eno2/Nse-Atg5 mice, where Atg5 is deficient in the whole body except for neurons, enables us to analyze the consequences of macroautophagy/autophagy-deficiency in the whole body of adult mice.
authors.affiliation: a Department of Biochemistry and Molecular Biology , Graduate School and Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Saori R
authors.initials: SR
authors.lastname: Yoshii
authors.affiliation: a Department of Biochemistry and Molecular Biology , Graduate School and Faculty of Medicine, The University of Tokyo , Tokyo , Japan.|b Japan Science and Technology Agency , PRESTO , Saitama , Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Kuma
authors.affiliation: a Department of Biochemistry and Molecular Biology , Graduate School and Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Mizushima
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D000071187:Autophagy-Related Protein 5 / Q000172:deficiency* / Q000378:metabolism; D018345:Mice, Knockout; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D009928:Organ Specificity; D019076:Transgenes
chemical_list: C495773:Atg5 protein, mouse; D000071187:Autophagy-Related Protein 5
keywords: ATG5; autophagy deficiency; hypogonadism; iron deficiency; neonatal lethality; neuronal dysfunction; suckling failure; systemic analysis