title: [Clinical features and prognostic analysis of neuromyelitisoptica spectrum disease with sjogrensyndrome].
abstract: Objective:To explore the clinical features and conduct prognostic analysis about visual recovery and relapse of neuromyelitisoptica (NMO) spectrum disease (NMOSD) with sjogren syndrome (SS).Methods:A retrospective and prospective observational study was conducted.Between July 2013 and June 2016, 172 patients with NMOSD (NMOSD-non SS: 116/172, 67.4%; NMOSD-SS: 56/172, 32.6%) were assessed at Beijing Tongren Hospital, Capital Medical University, Beijing, China.The prognostic factors of NMOSD-SS patients were also analyzed.Results:As compared with NMOSD-non SS patients, NMOSD-SS patients had worse visual impairment (percentage of patients with visual acuity less than 0.1, 83.9% vs 69.8%,P<0.05), higher positive rate of SSA (92.9% vs 0.0%,P<0.05), higher proportion of dryness of mouth and eye (66.1% vs 5.2%,P<0.05) as well as higher percentage of reduced visual evoked potential (VEP) amplitude (60.7% vs 43.1%,P<0.05). NMOSD-SS patients had a significantly higher average year recurrent frequency (0.58 vs 0.53) and significantly shorter mean recurrence time (6.7 months vs 12.4 months,P<0.05). The results showed that recurrent eyes, the worst visual acuities of onset less than 0.1 were independent risk factors of visual impairment (visual activity <0.1), according to at least six months' follow-up of all NMOSD-SS patients (OR=6.410 and 9.434, respectively,P<0.05). Meanwhile, immunosuppressive drugs were protective factors of relapse in NMOSD-SS patients (OR=0.107,P<0.05).Conclusions:NMOSD-SS patients have worse visual impairment, and they are more vulnerable to relapse than NMOSD-non SS patients, and the vision is lack of recovery for NMOSD-SS with recurrent eyes or the worst vision of onset less than 0.1.Immunosuppressive drugs can reduce the recurrence of NMOSD-SS relapse.
authors.affiliation: Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
authors.forename: N
authors.initials: N
authors.lastname: Jia
authors.forename: Y
authors.initials: Y
authors.lastname: Jing
authors.forename: Q C
authors.initials: QC
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: J W
authors.initials: JW
authors.lastname: Wang
authors.forename: X M
authors.initials: XM
authors.lastname: Hu
mesh_terms: D002681:China; D005074:Evoked Potentials, Visual; D006801:Humans; D009471:Neuromyelitis Optica; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012859:Sjogren's Syndrome; D015354:Vision, Low; D014792:Visual Acuity
keywords: Neuromyelitisoptica; Prognosis; Relapse; Sjogren syndrome; Visual acuity