title: Molecular connections of obesity and aging: a focus on adipose protein 53 and retinoblastoma protein.
abstract: Obesity is an induced health problem that human beings have been facing with non-optimal treatment so far. Humans are on average getting fatter with age, and obesity and aging interact each other to shorten lifetime and decrease life quality. Obesity also causes several aging related-disorders such as cancer, strokes, cardiovascular disease, high blood pressure and type 2 diabetes. So, the molecular connections between aging and obesity are promising targets for bio-medical researches and innovative therapies of many health problems. In this review, we discuss the findings of adipose p53 and Rb-two central molecular linkages between aging and obesity-on lipid metabolism and obesity.
authors.affiliation: Institute for Research and Development, Duy Tan University, K7/25 Quang Trung, Danang, Vietnam. chudinhtoi.hnue@gmail.com.|Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam. chudinhtoi.hnue@gmail.com.|Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway. chudinhtoi.hnue@gmail.com.
authors.forename: Dinh-Toi
authors.identifier: 0000-0002-4596-2022
authors.initials: DT
authors.lastname: Chu
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Tao
mesh_terms: D000273:Adipose Tissue / Q000503:physiopathology*; D000375:Aging; D000818:Animals; D006706:Homeostasis; D006801:Humans; D051379:Mice; D009765:Obesity / Q000503:physiopathology*; D016160:Retinoblastoma Protein / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D016160:Retinoblastoma Protein; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
keywords: Aging and obesity; p53 and Rb on adipogenesis; p53 and Rb on obesity