title: Current Treatment Algorithms for Patients with Metastatic Non-Small Cell, Non-Squamous Lung Cancer.
abstract: The treatment paradigm for metastatic non-small cell, non-squamous lung cancer is continuously evolving due to new treatment options and our increasing knowledge of molecular signal pathways. As a result of treatments becoming more efficacious and more personalized, survival for selected groups of non-small cell lung cancer (NSCLC) patients is increasing. In this paper, three algorithms will be presented for treating patients with metastatic non-squamous, NSCLC. These include treatment algorithms for NSCLC patients whose tumors haveEGFRmutations,ALKrearrangements, or wild-type/wild-type tumors. As the world of immunotherapy continues to evolve quickly, a future algorithm will also be presented.
authors.affiliation: Medical Oncology, British Columbia Cancer Agency, Vancouver Centre , Vancouver, BC , Canada.
authors.forename: Barbara
authors.initials: B
authors.lastname: Melosky
keywords: algorithm; anaplastic lymphoma kinase; chemotherapy; epidermal growth factor receptor; metastatic non-squamous non-small cell lung cancer; systemic therapy; targeted therapy