title: Co-Registered Molecular Logic Gate with a CO-Releasing Molecule Triggered by Light and Peroxide.
abstract: Co-registered molecular logic gates combine two different inputs and outputs, such as light and matter. We introduce a biocompatible CO-releasing molecule (CORM, A) as Mn(I) tricarbonyl complex with the ligand 5-(dimethylamino)-N, N-bis(pyridin-2-ylmethyl) naphthalene-1-sulfonamide (L). CO release is chaperoned by turn-on fluorescence and can be triggered by light (405 nm) as well as with hydrogen peroxide in aqueous phosphate buffer. Complex A behaves as a logic "OR" gate via co-registering the inputs of irradiation (light) and peroxide (matter) into the concomitant outputs fluorescence (light) and CO (matter). Cell viability assays confirm the low toxicity of A toward different human cell lines. The CORM has been used to track the inclusion of A into cancer cells.
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena , Humboldtstraße 8, D-07743 Jena, Germany.
authors.forename: Upendar Reddy
authors.initials: UR
authors.lastname: G
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena , Humboldtstraße 8, D-07743 Jena, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Axthelm
authors.affiliation: Leibniz Institute of Photonic Technology , Albert-Einstein-Straße 9, D-07745 Jena, Germany.|Center for Sepsis Control and Care (CSCC), Jena University Hospital , Am Klinikum 1, D-07747 Jena, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Hoffmann
authors.affiliation: Chromatin and Disease Biology Laboratory, National Center for Cell Science , 411007 Pune, India.
authors.forename: Nandaraj
authors.initials: N
authors.lastname: Taye
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena , Humboldtstraße 8, D-07743 Jena, Germany.
authors.forename: Steve
authors.initials: S
authors.lastname: Gläser
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena , Humboldtstraße 8, D-07743 Jena, Germany.
authors.forename: Helmar
authors.initials: H
authors.lastname: Görls
authors.affiliation: Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, 2333 CC Leiden, The Netherlands.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Hopkins
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena , Humboldtstraße 8, D-07743 Jena, Germany.
authors.forename: Winfried
authors.initials: W
authors.lastname: Plass
authors.affiliation: Leibniz Institute of Photonic Technology , Albert-Einstein-Straße 9, D-07745 Jena, Germany.|Center for Sepsis Control and Care (CSCC), Jena University Hospital , Am Klinikum 1, D-07747 Jena, Germany.
authors.forename: Ute
authors.initials: U
authors.lastname: Neugebauer
authors.affiliation: Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, 2333 CC Leiden, The Netherlands.
authors.forename: Sylvestre
authors.identifier: http://orcid.org/0000-0002-5810-3657
authors.initials: S
authors.lastname: Bonnet
authors.affiliation: Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena , Humboldtstraße 8, D-07743 Jena, Germany.
authors.forename: Alexander
authors.identifier: http://orcid.org/0000-0003-3888-8423
authors.initials: A
authors.lastname: Schiller