title: [Circulating microRNAs in the diagnostics of endocrine neoplasms].
abstract: MicroRNAs (miRNA, miR) are short - 19-25 nucleotide long - single stranded (in their mature form), non-coding RNA molecules that regulate gene expression mostly at the posttranscriptional level. microRNAs are involved in the regulation of various physiological processes such as cell differentiation and proliferation, development, haematopoesis, cell death, while their aberrant expression is observed in numerous diseases, like autoimmune disorders, inflammations, vascular diseases or tumorigenesis. microRNAs are expressed in a tissue specific fashion. Beyond their appearance in tissues, they can be found in body fluids as well. microRNAs are present in blood, mother milk, semen, saliva, urine, etc. MicroRNAs in body fluids, especially the blood-borne circulating microRNAs can be exploited as minimally invasive biomarkers of tumor diagnosis. The number of endocrine tumor-associated circulating microRNA alterations is relatively low, mostly described for papillary thyroid cancer, adrenocortical cancer, ovarian and neuroendocrine tumors. As the histological diagnosis including the establishment of malignancy of some of these neoplasms is difficult, studies on circulating microRNAs might have great perspectives. Orv. Hetil., 2017, 158(13), 483-490.
authors.affiliation: II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 26., 1085.
authors.forename: Ábel
authors.initials: Á
authors.lastname: Decmann
authors.affiliation: II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 26., 1085.
authors.forename: Pál
authors.initials: P
authors.lastname: Perge
authors.affiliation: II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 26., 1085.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Nagy
authors.affiliation: MTA-SE Molekuláris Medicina Kutatócsoport Budapest.
authors.forename: Henriett
authors.initials: H
authors.lastname: Butz
authors.affiliation: MTA-SE Molekuláris Medicina Kutatócsoport Budapest.|MTA-SE Lendület "Örökletes endokrin daganatok" Kutatócsoport Budapest.
authors.forename: Attila
authors.initials: A
authors.lastname: Patócs
authors.affiliation: II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 26., 1085.
authors.forename: Péter
authors.initials: P
authors.lastname: Igaz
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D004701:Endocrine Gland Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: adrenocortical carcinoma; daganat-biomarker; mellékvesekéreg-carcinoma; microRNA; mikroRNS; ovarian neoplasm; pajzsmirigydaganat; petefészek-daganat; thyroid neoplasm; tumor biomarker