title: Antioxidant phenolic compounds from the rhizomes of Astilbe rivularis.
abstract: The rhizomes of Astilbe rivularis, commonly known as 'Thulo Okhati' are widely used in Nepal as tonic for uterine and menstrual disorders. In our preliminary study, the 70% MeOH extract of the rhizomes showed potent antioxidant activity. Hence, present study was aimed for the isolation of potent antioxidant constituents. Bergenin (1), 11-O-galloylbergenin (2), (+)-catechin (3), (-)-catechin (4), (-)-afzelechin (5), (-)-epiafzelechin (6) and 2-(β-D-glucopyranosyloxy)-4-hydroxylbenzenacetonitrile (7) were isolated from the rhizomes. Structures of these compounds were elucidated on the basis of spectroscopic methods. All these isolated compounds were evaluated for their in vitro antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. 11-O-Galloylbergenin (2), (+)-catechin (3), (-)-catechin (4), (-)-afzelechin (5) and (-)-epiafzelechin (6) showed potent antioxidant activity.
authors.affiliation: a School of Pharmacy , Kumamoto University , Kumamoto , Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Hori
authors.affiliation: a School of Pharmacy , Kumamoto University , Kumamoto , Japan.
authors.forename: Mikiyo
authors.initials: M
authors.lastname: Wada
authors.affiliation: a School of Pharmacy , Kumamoto University , Kumamoto , Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Yahara
authors.affiliation: a School of Pharmacy , Kumamoto University , Kumamoto , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: a School of Pharmacy , Kumamoto University , Kumamoto , Japan.|b Program for Leading Graduate Schools, Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program , Kumamoto University , Kumamoto , Japan.
authors.forename: Hari Prasad
authors.initials: HP
authors.lastname: Devkota
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D002392:Catechin / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009390:Nepal; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: C556377:11-O-galloylbergenin; D000975:Antioxidants; D001578:Benzopyrans; D001713:Biphenyl Compounds; D005419:Flavonoids; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; C120647:epiafzelechin; D005707:Gallic Acid; D002392:Catechin; C004931:1,1-diphenyl-2-picrylhydrazyl; C006741:bergenin; C510796:afzelechin
keywords: Astilbe rivularis; Thulo Okhati; antioxidant activity; bergenin