title: Enhancer-Derived lncRNAs Regulate Genome Architecture: Fact or Fiction?
abstract: How does the non-coding portion of the genome contribute to the regulation of genome architecture? A recent paper by Tan et al. focuses on the relationship between cis-acting complex-trait-associated lincRNAs and the formation of chromosomal contacts in topologically associating domains (TADs).
authors.affiliation: Division of Chemical, Systems, and Synthetic Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Gene Expression and Biophysics Group, Biomedical Translational Research Initiative (BTRI), Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, South Africa. Electronic address: parrucchiere@mhlangalab.org.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Fanucchi
authors.affiliation: Division of Chemical, Systems, and Synthetic Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Gene Expression and Biophysics Group, Biomedical Translational Research Initiative (BTRI), Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, South Africa. Electronic address: yoda@mhlangalab.org.
authors.forename: Musa M
authors.initials: MM
authors.lastname: Mhlanga
mesh_terms: D002875:Chromosomes / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D044127:Epigenesis, Genetic; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D011401:Promoter Regions, Genetic; D062085:RNA, Long Noncoding / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics
chemical_list: D062085:RNA, Long Noncoding