title: De novoperoxisome biogenesis revisited.
abstract: We describe an alternative peroxisome formation pathway in yeastpex3andpex19cells, which relies on the existence of small peroxisomal remnants that are present in these cells. This groundbreaking result challenges current models prescribing that peroxisomes derivede novofrom the ER. Our data also has major implications for the sorting pathway of specific peroxisomal membrane proteins (PMPs). We propose a novel sorting pathway for the PMPs Pex13 and Pex14 that is independent of the known Pex3/Pex19 machinery.
authors.affiliation: Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.
authors.forename: Marten
authors.initials: M
authors.lastname: Veenhuis
authors.affiliation: Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.
authors.forename: Ida J V D
authors.initials: IJ
authors.lastname: Klei
keywords: de novo peroxisome formation; endoplasmic reticulum; peroxisome deficient mutant; peroxisomes; yeast