title: Acacia gum polysaccharide based hydrogel wound dressings: Synthesis, characterization, drug delivery and biomedical properties.
abstract: Keeping in view the importance of polysaccharide gums for wound care, in the present article, an attempt has been made to explore antioxidant nature of gum acacia in designing hydrogel wound dressing to improve its wound healing potential. These polymers were prepared by using acacia gum-polyvinylpyrollidone/carbopol and were characterized by13C NMR, FTIR, SEM, AFM, cryo-SEM, XRD, TGA, DSC and elemental analysis techniques. Some important biomaterial properties of wound dressings such as wound fluid absorption, haemo-compatibility, bioactive assessment, gaseous/water/microbial permeability, mechanical properties, bio-adhesion, drug release, and histology of wound healing were also determined. Hydrogel wound dressings were found non-haemolytic, antioxidant and mucoadhesive in nature. Release of drug occurred through non-Fickian diffusion mechanism and release profile best fitted in Higuchi model.
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla 171005, India. Electronic address: baljitsinghhpu@yahoo.com.
authors.forename: Baljit
authors.initials: B
authors.lastname: Singh
authors.affiliation: Department of Biosciences, Himachal Pradesh University, Shimla 171005, India.
authors.forename: Sushma
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Dhiman
mesh_terms: D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006170:Gum Arabic / Q000737:chemistry*; D020100:Hydrogels; D008807:Mice, Inbred BALB C; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D011134:Polysaccharides; D006170:Gum Arabic
keywords: Acacia-gum; Drug delivery; Wound dressing