title: Laying in silico pipelines for drug repositioning: a paradigm in ensemble analysis for neurodegenerative diseases.
abstract: When faced with time- and money-consuming problems, new practices in pharmaceutical R&D arose when trying to alleviate them. Drug repositioning has great promise and when combined with today's computational power and intelligence it becomes more precise and potent. This work showcases current approaches of creating a computational pipeline for drug repositioning, along with an extensive example of how researchers can influence therapeutic approaches and further understanding, through either single or multiple disease studies. This paradigm is based on three neurodegenerative diseases with pathophysiological similarities. It is our goal to provide the readers with all the information needed to enrich their research and note expectations along the way.
authors.affiliation: Laboratory of Pharmacology, Department of Medicine, Democritus University of Thrace, Greece.
authors.forename: Nikolas
authors.initials: N
authors.lastname: Dovrolis
authors.affiliation: Laboratory of Pharmacology, Department of Medicine, Democritus University of Thrace, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Kolios
authors.affiliation: Bioinformatics ERA Chair, The Cyprus Institute of Neurology and Genetics, Cyprus.
authors.forename: George
authors.initials: G
authors.lastname: Spyrou
authors.affiliation: Department of Molecular Biology & Genetics, Democritus University of Thrace, Greece. Electronic address: imaroula@mbg.duth.gr.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Maroulakou
mesh_terms: D000818:Animals; D019295:Computational Biology; D003198:Computer Simulation; D058492:Drug Repositioning; D006801:Humans; D019636:Neurodegenerative Diseases / Q000188:drug therapy*