title: Evaluation of Prognostic Immune Signatures in Patients with Breast, Colorectal and Pancreatic Cancer Receiving Chemotherapy.
abstract: CD97 is a member of the epidermal growth factor-seven transmembrane (EGF-TM7) receptor family and is dominantly expressed on immune cells and in a variety of malignant diseases. B7-H1 and B7-H3 are transmembrane proteins that are involved in suppression of the immune system. The aim of this study was to evaluate if these molecules are up-regulated in patients with cancer and change during chemotherapy.
  
  
  
  We analyzed cluster of differentiation (CD) protein expression levels on tumor cell lines and in blood samples of 37 patients with solid tumors at baseline and during chemotherapy; we correlated the serum levels of CD proteins with survival outcome.
  
  
  
  Levels of soluble CD97 proteins were significantly elevated in all three cancer types compared to healthy controls. Patients with colorectal cancer and those with high CD97 levels had a significantly worse prognosis.
  
  
  
  This study showed a marked elevation of soluble CD97 expression in patients with certain cancer types and demonstrated definite changes in CD protein expression during chemotherapy in one patient with metastatic breast cancer.
authors.affiliation: Internal Medicine I, Department of Oncology, St. Josef Hospital, Vienna, Austria ursula.vogl@sjk-wien.at.
authors.forename: Ursula M
authors.initials: UM
authors.lastname: Vogl
authors.affiliation: Internal Medicine I, Department of Oncology, St. Josef Hospital, Vienna, Austria.
authors.forename: Leopold
authors.initials: L
authors.lastname: Öhler
authors.affiliation: Department of Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: Masa
authors.initials: M
authors.lastname: Rasic
authors.affiliation: Department of Neurosurgery, Medical University Vienna, Vienna, Austria.
authors.forename: Josa M
authors.initials: JM
authors.lastname: Frischer
authors.affiliation: Department of Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: Madhura
authors.initials: M
authors.lastname: Modak
authors.affiliation: Department of Immunology, Medical University Vienna, Vienna, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Stöckl
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D011379:Prognosis; D015996:Survival Rate
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D014408:Biomarkers, Tumor
keywords: B7-H1; CD274; CD276; CD97; immune signatures; solid tumors; transmembrane proteins