title: KRAS Allelic Imbalance: Strengths and Weaknesses in Numbers.
abstract: The identification of therapeutic vulnerabilities in mutant KRAS tumors has proven difficult to achieve. Burgess and colleagues recently reported in Cell that mutant/wild-type Kras allelic dosage determines clonal fitness and MEK inhibitor sensitivity in a leukemia model, demonstrating that KRAS allelic imbalance is likely an important and overlooked variable.
authors.affiliation: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK; Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Box 193, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Doherty
authors.affiliation: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK.
authors.forename: Emma M
authors.initials: EM
authors.lastname: Kerr
authors.affiliation: MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge, CB2 0XZ, UK. Electronic address: c.martins@mrc-cu.cam.ac.uk.
authors.forename: Carla P
authors.initials: CP
authors.lastname: Martins
mesh_terms: D022981:Allelic Imbalance / Q000235:genetics*; D001549:Benzamides / Q000494:pharmacology; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D018628:Gene Dosage / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000235:genetics; D048369:MAP Kinase Kinase 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D048370:MAP Kinase Kinase 2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D008962:Models, Theoretical; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*
chemical_list: D001549:Benzamides; C506614:mirdametinib; D004159:Diphenylamine; C482128:MAP2K2 protein, human; D048369:MAP Kinase Kinase 1; D048370:MAP Kinase Kinase 2; C482125:MAP2K1 protein, human; D016283:Proto-Oncogene Proteins p21(ras)