title: Diffusion-weighted imaging in evaluating the efficacy of concurrent chemoradiotherapy in the treatment of non-small cell lung cancer.
abstract: OBJECTIVE
  To explore the predictive value of diffusion-weighted imaging (DWI) in evaluating the short-term efficacy of concurrent chemoradiotherapy (CCRT) in the treatment of patients with non-small cell lung cancer (NSCLC).
  
  
  METHODS
  A total of 192 patients with NSCLC were selected and treated with CCRT. Dynamic contrast-enhanced magnetic resonance imaging combined with DWI was performed on all patients before and after CCRT treatment. Correspondingly, apparent diffusion coefficient (ADC) values were recorded before treatment (ADCpre), during treatment (ADCmid), and after treatment (ADCpost). Tumor response was evaluated as complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD). Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic power of quantitative DWI parameters in predicting the short-term efficacy of CCRT for patients with NSCLC.
  
  
  RESULTS
  There were 21 patients with CR, 82 with PR, 77 with SD, and 12 with PD. The ADCprewas negatively correlated with tumor regression rate, whereas ADCmid, ADCpost, and their respective change rates ∆ADCmidand ∆ADCpostwere positively related to tumor regression rate. The ROC curve analysis suggested ADCpre= 1.38 × 10-3mm2/s, ∆ADCmid= 14.14%, and ∆ADCpost= 20.39% as thresholds to predict the short-term efficacy of CCRT, with corresponding areas under the curve of 0.637, 0.743, and 0.752, respectively.
  
  
  CONCLUSIONS
  These findings indicate that DWI provides promising predictive value in evaluating the short-term efficacy of CCRT in the treatment of patients with NSCLC.
authors.affiliation: 1 Department of Radiology, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang - PR China.
authors.forename: Hai-Dong
authors.initials: HD
authors.lastname: Xu
authors.affiliation: 1 Department of Radiology, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang - PR China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Zhang
authors.affiliation: 2 Department of Thoracic Surgery, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang - PR China.
authors.forename: Wei-Yu
authors.initials: WY
authors.lastname: Shen
authors.affiliation: 2 Department of Thoracic Surgery, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, Zhejiang - PR China.
authors.forename: Zheng-Chun
authors.initials: ZC
authors.lastname: Mao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D016896:Treatment Outcome
keywords: Concurrent chemoradiotherapy; Diffusion-weighted imaging; Magnetic resonance imaging; Non-small cell lung cancer; Short-term efficacy