title: Ruthenium bipyridine sensitized MoO3multifunctional nanostructures: Study of opto-electrochemical properties, biocompatibility and bioimaging.
abstract: Simple and versatile methodology to synthesize hybrid nanostructures with multi-functionality for device application is advantageous. Herein, we report the synthesis of MoO3nanostructures integrated with [Ru(bpy)3]2+and PEGylation to obtain hybrid MoO3-[Ru(bpy)3]2+nanostructures. Chemically interacted [Ru(bpy)3]2+provides optical and electrochemical properties to the hybrid structures. PEG3kenhances the aqueous solubility of the hybrid system. Morphology, chemical structure, optical and electrochemical properties of hybrid nanostructures were studied from electron microscopic, spectroscopic and voltammetric techniques. The synthesized hybrid nanostructures exhibited a metal-to-ligand charge transfer absorbance and emission bands in the range of 450nm and 605nm, respectively. Electrode modified with MoO3-[Ru(bpy)3]2+and MoO3-[Ru(bpy)3]2+/PEG3kexhibit improved voltammetric properties than pristine MoO3. Confocal cellular imaging supported that these hybrid particles were easily uptaken by endothelial cells with minimal cytotoxic effects. The hybrid nanocomplex displayed unique opto-electrochemical, cellular biocompatibility and imaging features that may be an ideal platform for electrochemical biosensor devices with simultaneous bioimaging function.
authors.affiliation: National Institute of Pharmaceutical Education and Research, Kolkata 700032, West Bengal, India. Electronic address: momugan@gmail.com.
authors.forename: Murugan
authors.initials: M
authors.lastname: Veerapandian
authors.affiliation: Department of Biophysics, Postgraduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India. Electronic address: pramod.avti@gmail.com.
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Avti
authors.affiliation: National Institute of Pharmaceutical Education and Research, Kolkata 700032, West Bengal, India.
authors.forename: V
authors.initials: V
authors.lastname: Ravichandiran
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D015374:Biosensing Techniques; D001921:Brain / Q000166:cytology / Q000502:physiology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D055664:Electrochemical Techniques; D004566:Electrodes; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D051379:Mice; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods*; D008982:Molybdenum / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009942:Organometallic Compounds / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility
chemical_list: D001672:Biocompatible Materials; D009942:Organometallic Compounds; D010087:Oxides; C571913:bis(ruthenium-bipyridine); C082290:molybdenum trioxide; D011092:Polyethylene Glycols; D008982:Molybdenum
keywords: Cellular bioimaging; Molybdenum trioxide; Opto-electrochemical sensitizer; PEGylation; [Ru(bpy)(3)](2+)