title: Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases.
abstract: High-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and is one of the most intriguing molecules in inflammatory disorders and cancers. Notably, HMGB1 is a potential therapeutic target and novel biomarker in related diseases. However, the diagnostic value of HMGB1 for benign and malignant asbestos-related diseases (ARDs) remains unclear. In this work, we detected preoperative serum HMGB1 levels in Chinese asbestos-exposed (AE) and ARDs populations and further evaluated the diagnostic value of HMGB1 in patients with certain types of ARDs, including those with pleural plaques, asbestosis, or malignant mesothelioma (MM). The experimental data presented that the serum level of HMGB1 was significantly elevated in AE and ARDs subjects. Our findings indicated that serum HMGB1 is a sensitive and specific biomarker for discriminating asbestosis- and MM-affected individuals from healthy or AE individuals. In addition, serum matrix metalloproteinases 2 and 9 are not correlated with HMGB1 in ARDs. Thus, our study provides supporting evidence for HMGB1 as a potential biomarker either for the clinical diagnosis of high-risk AE cohorts or for evaluating ARDs.
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Shibo
authors.identifier: 0000-0001-5275-9383
authors.initials: S
authors.lastname: Ying
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Zhaoqiang
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Xianglei
authors.initials: X
authors.lastname: He
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yu
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Riping
authors.initials: R
authors.lastname: Chen
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Junqiang
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Ru
authors.affiliation: Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, China.
authors.forename: Wanyuan
authors.initials: W
authors.lastname: Chen
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Lijin
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Yixiao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Xinnian
authors.initials: X
authors.lastname: Guo
authors.affiliation: Jiading District Center for Disease Control and Prevention, Shanghai 201800, China.
authors.forename: Xianhong
authors.initials: X
authors.lastname: Yin
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Jianlin
authors.identifier: 0000-0002-4052-7865
authors.initials: J
authors.lastname: Lou
mesh_terms: D000368:Aged; D001195:Asbestosis / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008654:Mesothelioma / Q000097:blood*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9