title: Membrane Oxidation in Cell Delivery and Cell Killing Applications.
abstract: Cell delivery or cell killing processes often involve the crossing or disruption of cellular membranes. We review how, by modifying the composition and properties of membranes, membrane oxidation can be exploited to enhance the delivery of macromolecular cargoes into live human cells. We also describe how membrane oxidation can be utilized to achieve efficient killing of bacteria by antimicrobial peptides. Finally, we present recent evidence highlighting how membrane oxidation is intimately engaged in natural biological processes such as antigen delivery in dendritic cells and in the killing of bacteria by antimicrobial peptides. Overall, the insights that have been recently gained in this area should facilitate the development of more effective delivery technologies and antimicrobial therapeutic approaches.
authors.affiliation: Department of Biochemistry and Biophysics, Texas A&M University , College Station, Texas 77843, United States.
authors.forename: Ting-Yi
authors.initials: TY
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: M Daben J
authors.initials: MDJ
authors.lastname: Libardo
authors.affiliation: Department of Chemistry, University of Connecticut , Storrs, Connecticut 06269, United States.
authors.forename: Alfredo M
authors.identifier: 0000-0002-5560-4405
authors.initials: AM
authors.lastname: Angeles-Boza
authors.affiliation: Department of Biochemistry and Biophysics, Texas A&M University , College Station, Texas 77843, United States.|Department of Chemistry, Texas A&M University , College Station, Texas 77843, United States.
authors.forename: Jean-Philippe
authors.identifier: 0000-0001-5536-925X
authors.initials: JP
authors.lastname: Pellois
mesh_terms: D000941:Antigens / Q000008:administration & dosage; D023181:Antimicrobial Cationic Peptides / Q000008:administration & dosage / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D016923:Cell Death; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D002463:Cell Membrane Permeability; D003713:Dendritic Cells / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D010084:Oxidation-Reduction
chemical_list: D000941:Antigens; D023181:Antimicrobial Cationic Peptides