title: Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides.
abstract: A palladium-catalyzed fluorosulfonylvinylation reaction of organic iodides is described. Catalytic Pd(OAc)2with a stoichiometric amount of silver(I) trifluoroacetate enables the coupling process between either an (hetero)aryl or alkenyl iodide with ethenesulfonyl fluoride (ESF). The method is demonstrated in the successful syntheses of eighty-eight otherwise difficult to access compounds, in up to 99 % yields, including the unprecedented 2-heteroarylethenesulfonyl fluorides and 1,3-dienylsulfonyl fluorides.
authors.affiliation: State Key Laboratory of Silicate Materials for Architectures, and School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, China.
authors.forename: Gao-Feng
authors.initials: GF
authors.lastname: Zha
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
authors.forename: Qinheng
authors.identifier: 0000-0002-8440-8673
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Silicate Materials for Architectures, and School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Leng
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Silicate Materials for Architectures, and School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan, 430070, China.
authors.forename: Hua-Li
authors.identifier: 0000-0002-6609-0083
authors.initials: HL
authors.lastname: Qin
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA.
authors.forename: K Barry
authors.initials: KB
authors.lastname: Sharpless
keywords: alkenes; click chemistry; drug discovery; fluorine; palladium