title: Meningioma recurrence.
abstract: Meningioma accounts for more than 30% of all intracranial tumours. It affects mainly the elderly above the age of 60, at a female:male ratio of 3:2. The prognosis is variable: it is usually favourable with no progression in tumour grade and no recurrence in WHO grade 1 tumours. However, a minority of tumours represent atypical (grade 2) or anaplastic (grade 3) meningiomas; this heterogeneity is also reflected in histopathological appearances. Irrespective of the grade, the size of the tumour and the localisation may have severe, sometimes lethal consequences. Following neurosurgical interventions to remove the tumour, recurrence and progression in WHO grade may occur. Our knowledge on predisposing histomorphological and molecular factors of recurrence is rather limited. These can be classified as I) demographic II) environmental, III) genetic and epigenetic IV) imaging, V) neuropathological, and VI) neurosurgical. In view of the complex background of tumour recurrence, the recognition of often subtle signs of increased risk of recurrence requires close collaboration of experts from several medical specialties. This multidisciplinary approach results in better therapy and fewer complications related to tumour recurrence.
authors.affiliation: Division of Neuropathology, Institute of Pathology, University of Debrecen, Debrecen, Nagyerdei krt. 98., H-4032, Hungary.
authors.forename: Tibor
authors.initials: T
authors.lastname: Hortobágyi
authors.affiliation: Division of Neuropathology, Institute of Pathology, University of Debrecen, Debrecen, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Bencze
authors.affiliation: Division of Neuropathology, Institute of Pathology, University of Debrecen, Debrecen, Hungary.
authors.forename: Gréta
authors.initials: G
authors.lastname: Varkoly
authors.affiliation: Division of Neuropathology, Institute of Pathology, University of Debrecen, Debrecen, Hungary.
authors.forename: Mahan C
authors.initials: MC
authors.lastname: Kouhsari
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Álmos
authors.initials: Á
authors.lastname: Klekner
keywords: Genetics; Immunohistochemistry; Meningioma; Molecular biology; Neuropathology; Pathology; Prognostic factors; Recurrence