title: Photodynamic dye adsorption and release performance of natural zeolite.
abstract: Clinoptilolite type of zeolite (CZ) is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms and organic molecules into micropores. Using multiphoton microscopy, we demonstrated that individual CZ particles produce two-photon excited luminescence and second harmonic generation signal at femtosecond laser excitation, and adsorb photo-dynamically active dyes such as hypericin and methylene blue. Furthermore, the release of hypericin from CZ pores in the presence of biomolecules is shown, and CZ can be considered as an effective material for drug delivery and controlled release in biological systems. The results may open new perspectives in application of CZ in biomedical imaging, and introducing of the optical approaches into the clinical environment.
authors.affiliation: College of Photonics, National Chiao Tung University, Tainan 711, Taiwan.|Department of Physics, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Hovhannisyan
authors.affiliation: Department of Physics, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Chen-Yuan
authors.initials: CY
authors.lastname: Dong
authors.affiliation: College of Photonics, National Chiao Tung University, Tainan 711, Taiwan.|Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Shean-Jen
authors.initials: SJ
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D004396:Coloring Agents / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D008751:Methylene Blue / Q000737:chemistry*; D017641:Zeolites / Q000737:chemistry*
chemical_list: D004396:Coloring Agents; D003692:Delayed-Action Preparations; C083175:clinoptilolite; D017641:Zeolites; D008751:Methylene Blue