title: Spontaneous splenic rupture in an acute leukemia patient with splenic tuberculosis: A case report.
abstract: Spontaneous splenic rupture, also referred to as atraumatic splenic rupture, is a rare but life-threatening emergency condition. Without timely diagnosis and treatment, the mortality rate of splenic rupture approaches 100%. The etiology of atraumatic splenic rupture varies; it is reportedly associated with neoplasms or splenic infection, but is rarely encountered in patients with both conditions. We herein report the case of a 58-year-old male patient with acute myeloid leukemia (AML) complicated by splenic tuberculosis (TB), who presented with spontaneous rupture of the spleen. Pathological examination of the resected spleen revealed multifocal granulomatosis with caseous necrosis. However, with timely diagnosis and surgical intervention, the patient recovered successfully and is currently on consolidation therapy. To the best of our knowledge, this is the first case of spontaneous splenic rupture in AML with splenic TB. The relevant literature on spontaneous splenic rupture was also reviewed and the potential etiology and treatment were discussed.
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zeng
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Xiaohuan
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Pathology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Pathology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Fengge
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101149, P.R. China.
authors.forename: Hebing
authors.initials: H
authors.lastname: Zhou
keywords: acute leukemia; splenic tuberculosis; spontaneous splenic rupture