title: DOCA-Salt Hypertension: an Update.
abstract: Hypertension is a multifaceted disease that is involved in ∼40% of cardiovascular mortalities and is the result of both genetic and environmental factors. Because of its complexity, hypertension has been studied by using various models and approaches, each of which tends to focus on individual organs or tissues to isolate the most critical and treatable causes of hypertension and the related damage to end-organs. Animal models of hypertension have ranged from Goldblatt's kidney clip models in which the origin of the disease is clearly renal to animals that spontaneously develop hypertension either through targeted genetic manipulations, such as the TGR(mRen2)27, or selective breeding resulting in more enigmatic origins, as exemplified by the spontaneously hypertensive rat (SHR). These two genetically derived models simulate the less-common human primary hypertension in which research has been able to define a Mendelian linkage. Several models are more neurogenic or endocrine in nature and illustrate that crosstalk between the nervous system and hormones can cause a significant rise in blood pressure (BP). This review will examine one of these neurogenic models of hypertension, i.e., the deoxycorticosterone acetate (DOCA), reduced renal mass, and high-salt diet (DOCA-salt) rodent model, one of the most common experimental models used today. Although the DOCA-salt model is mainly believed to be neurogenic and has been shown to impact the central and peripheral nervous systems, it also significantly involves many other body organs.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, School of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, Room 5218, New Orleans, LA, 70112, USA.|Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
authors.forename: Tyler
authors.initials: T
authors.lastname: Basting
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, School of Medicine, Louisiana State University Health Sciences Center, 1901 Perdido Street, Room 5218, New Orleans, LA, 70112, USA. elazar@lsuhsc.edu.|Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA. elazar@lsuhsc.edu.|Neurosciences Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA, USA. elazar@lsuhsc.edu.
authors.forename: Eric
authors.initials: E
authors.lastname: Lazartigues
mesh_terms: D000818:Animals; D001794:Blood Pressure; D064791:Desoxycorticosterone Acetate / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology; D017673:Sodium Chloride, Dietary
chemical_list: D017673:Sodium Chloride, Dietary; D064791:Desoxycorticosterone Acetate
keywords: Cardiovascular; DOCA-salt; Immune; Neurogenic hypertension; Neurohormonal; Renal