title: The Application of Nanomaterials in Stem Cell Therapy for Some Neurological Diseases.
abstract: Stem cell therapy provides great promising therapeutic benefits for various neurological disorders. Cell transplantation has emerged as cell replacement application for nerve damage. Recently, nanomaterials obtain wide development in various industrial and medical fields, and nanoparticles have been applied in the neurological field for tracking and treating nervous system diseases. Combining stem cells with nanotechnology has raised more and more attentions; and it has demonstrated that the combination has huge effects on clinical diagnosis and therapeutics in multiple central nervous system diseases, meanwhile, improves prognosis.
  
  
  
  The aim of this review was to give a brief overview of the application of nanomaterials in stem cell therapy for neurological diseases.
  
  
  
  Nanoparticles not only promote stem cell proliferation and differentiation in vitro or in vivo, but also play dominant roles on stem cell imaging and tracking. Furthermore, via delivering genes or drugs, nanoparticles can participate in stem cell therapeutic applications for various neurological diseases, such as ischemic stroke, spinal cord injury (SCI), multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD) and gliomas. However, nanoparticles have potential cytotoxic effects on nerve cells, which are related to their physicochemical properties.
  
  
  
  Nano-stem cell-based therapy as a promising strategy has the ability to affect neuronal repair and regeneration in the central nervous system.
authors.affiliation: Department of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
authors.forename: Guilong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
authors.forename: Ahsan Ali
authors.initials: AA
authors.lastname: Khan
authors.affiliation: School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
authors.forename: Lukui
authors.initials: L
authors.lastname: Chen
authors.affiliation: Aston Institute of Regenerative Medicine, Aston Medical School, Aston University, Birmingham, United Kingdom.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Gu
authors.affiliation: School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Gu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D058948:Cell Tracking; D006801:Humans; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*; D009422:Nervous System Diseases / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000166:cytology*
keywords: CNS diseases; Stem cell; cell transplantation; nanoparticles; neurogenesis; tracking