title: In Vivo Study of the Efficacy of the Essential Oil of Zanthoxylum bungeanum Pericarp in Dextran Sulfate Sodium-Induced Murine Experimental Colitis.
abstract: The purpose of this study was to investigate the protective effects and mechanisms of the essential oil of Zanthoxylum bungeanum pericarp (ZBEO) on dextran sulfate sodium (DSS)-induced experimental colitis in mice. ZBEO decreased DSS-induced body weight loss, the disease activity index, colon length shortening, colonic pathological damage, and myeloperoxidase activities. The production of pro-inflammatory mediators was significantly alleviated by ZBEO. Further mechanistic analysis showed that ZBEO inhibited inflammation by regulating NF-κB and PPARγ pathways. ZBEO also inhibited NLRP3 activation in colitis in mice. Furthermore, ZBEO contributed to the maintenance of tight junction architecture by regulating the expression of zonula occludens-1 during colitis. Surprisingly, treatment with ZBEO increased levels of the commensal bacteria containing Lactobacillus and Bifidobacteria but reduced Escherichia coli levels in the feces of mice. These results suggested that supplementation with ZBEO might provide a new dietary strategy for the prevention of ulcerative colitis.
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Zecai
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shen
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Jiuxi
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Cong
authors.initials: C
authors.lastname: Gu
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Lu
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Yongguo
authors.initials: Y
authors.lastname: Cao
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Yunhe
authors.initials: Y
authors.lastname: Fu
authors.affiliation: College of Veterinary Medicine, Jilin University , Changchun 130062, People's Republic of China.
authors.forename: Naisheng
authors.initials: N
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D003106:Colon / Q000187:drug effects / Q000276:immunology; D016264:Dextran Sulfate / Q000009:adverse effects; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein / Q000235:genetics / Q000276:immunology; D009822:Oils, Volatile / Q000008:administration & dosage*; D047495:PPAR gamma / Q000235:genetics / Q000276:immunology; D010936:Plant Extracts / Q000008:administration & dosage*; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D016328:NF-kappa B; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D009822:Oils, Volatile; D047495:PPAR gamma; D010936:Plant Extracts; D016264:Dextran Sulfate
keywords: ZO-1; Zanthoxylum bungeanum pericarp; colitis; essential oil; inflammation; intestinal microbiota