title: Plasma miR-122 as a potential diagnostic and prognostic indicator in human glioma.
abstract: Gliomas are the most common and aggressive brain tumors, and a poor prognosis is correlated with its World Health Organization (WHO) grade. MicroRNAs (miRNAs) may serve as diagnostic and prognostic biomarkers in gliomas. In the present study, we collected plasma samples from patients with gliomas to evaluate the expression of miR-122 and analyzed the role of miR-122 in the diagnosis and prognosis of gliomas. We found that the expression of miR-122 in the plasma of patients with gliomas was significantly down-regulated compared to that in healthy individuals. In addition, the expression of miR-122, which was significantly correlated with WHO grade, decreased along with the development of gliomas. A receiver operating characteristic curve analysis showed high sensitivity and specificity of miR-122 for diagnosing gliomas (sensitivity 91.9%; specificity 81.1%; area under the curve 0.939). Finally, we found that lower expression of miR-122 was correlated with poor prognosis, and miR-122 was an independent prognostic parameter indicating poor prognosis for gliomas. In conclusion, our results showed that plasma miR-122 expression might act as a diagnostic and prognostic biomarker for gliomas.
authors.affiliation: Zaozhuang Hospital of Zaozhuang Mining Group, NO.188 Shengli Road, Zaozhuang, 277101, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
authors.affiliation: The Third People's Hospital of Liaocheng, No. 62 Weiyu Road, Liaocheng, 252000, People's Republic of China.
authors.forename: Shunfeng
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Central Hospital of Shengli Oilfield, No. 31 Jinan Road, Dongying, 257034, People's Republic of China.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Juye County People's Hospital, No. 3 Wenhua Road, Heze, 274900, People's Republic of China.
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Li
authors.affiliation: The Sixth People's Hospital of Qingdao, No. 9 Fushun Road, Qingdao, 266003, People's Republic of China. ren129919@sina.com.
authors.forename: Qingbo
authors.initials: Q
authors.lastname: Ren
authors.affiliation: Central Hospital of Shengli Oilfield, No. 31 Jinan Road, Dongying, 257034, People's Republic of China. xiaoshouzhi@126.com.
authors.forename: Yurong
authors.initials: Y
authors.lastname: Tang
mesh_terms: D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood; D001932:Brain Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D005260:Female; D005910:Glioma / Q000097:blood* / Q000473:pathology / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D011379:Prognosis; D016016:Proportional Hazards Models; D012372:ROC Curve; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; C531907:MIRN122 microRNA, human; D035683:MicroRNAs
keywords: Biomarker; Diagnose; Glioma; Prognosis; miR-122