title: Use of neurotransmitter regulators in functional gastrointestinal disorders based on symptom analysis.
abstract: It has been a great challenge for gastroenterologists to cope with functional gastrointestinal disorders (FGIDs) in clinical practice due to the contemporary increase in stressful events. A growing body of evidence has shown that neuroregulators such as anti-anxiety agents and antidepressants function well on FGIDs, particularly in cases that are refractory to classical gastrointestinal (GI) medications. Among these central-acting agents, small individualized doses of tricyclic antidepressants and selective serotonin reuptake inhibitors are usually recommended as a complement to routine GI management. When these drugs are chosen to treat FGIDs, both their central effects and the modulation of peripheral neurotransmitters should be taken into consideration. In this article we recommend strategies for choosing drugs based on an analysis of psychosomatic GI symptoms. The variety and dosage of the neurotransmitter regulators are also discussed.
authors.affiliation: Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Qing Qing
authors.identifier: http://orcid.org/0000-0002-3401-9135
authors.initials: QQ
authors.lastname: Luo
authors.affiliation: Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Sheng Liang
authors.initials: SL
authors.lastname: Chen
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D003073:Cognitive Dissonance; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology / Q000523:psychology*; D006801:Humans; D001523:Mental Disorders / Q000150:complications / Q000628:therapy; D019964:Mood Disorders / Q000150:complications / Q000188:drug therapy; D018377:Neurotransmitter Agents / Q000502:physiology*; D011602:Psychophysiologic Disorders / Q000188:drug therapy*
chemical_list: D000928:Antidepressive Agents; D018377:Neurotransmitter Agents
keywords: antidepressive agents; functional gastrointestinal disorders; neurotransmitter agents; psychosomatic medicine