title: Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens.
abstract: A simple and sensitive electrochemical sensor fabricated with graphene nanosheets (GNs) and a hydroxyapatite (HA) nanocomposite-modified glassy carbon electrode (GCE) was developed for the determination of matrine (MT). The as-prepared electrode (GNs/HA/GCE) was verified to outperform bare a GCE and GNs-modified electrode with increased oxidation peak currents and the decreased over-potential in the redox process of MT, indicating the great enhancement of electrocatalytic activity toward the oxidation of MT by the composite of GNs and HA. Under the optimized conditions, the oxidation peak currents were related linearly with the concentration of MT, ranging from 2 μM to 3 mM, and the detection limit (S/N = 3) was 1.2 μM. In addition, the proposed electrochemical sensor can be successfully applied in the quantitative determination of MT inSophora flavescensextract.
authors.affiliation: Department of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou 450000, Henan, China. zhangjunping888@163.com.
authors.forename: Junping
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Traditional Chinese Medicine, Henan Province People's Hospital, Zhengzhou 450002, Henan, China. wang88982@126.com.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, Henan Academy institute of Traditional Chinese Medicine, Zhengzhou 450000, Henan, China. weizheng_zz@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000470:Alkaloids / Q000032:analysis*; D015374:Biosensing Techniques; D055664:Electrochemical Techniques; D006108:Graphite; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D010084:Oxidation-Reduction; D011807:Quinolizines / Q000032:analysis*; D029909:Sophora / Q000737:chemistry*; D000093842:Matrines
chemical_list: D000470:Alkaloids; D011807:Quinolizines; D006108:Graphite; D000093842:Matrines
keywords: Sophora flavescens; electrochemistry; hydroxyapatite; matrine; voltammetric sensors