title: A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity.
abstract: A membrane-intercalating conjugated oligoelectrolyte (COE), PTTP, was designed and synthesized with the goal of providing red-shifted absorption spectra relative to previously synthesized COE analogs. Specifically, electron-rich and electron-poor subunits were introduced in the conjugated backbone to modulate the band gap. PTTP exhibits maxima of absorption at 507 nm and of emission at 725 nm. PTTP can also efficiently function to generate singlet oxygen in situ (ΦΔ≈20 %) and has appropriate topology and dimensions to interact with lipid membranes. The resulting rapid membrane insertion and sensitizing ability provide PTTP with a highly efficient antibacterial capability under a low light dose (0.6 J cm-2) toward Gram-negative bacteria E. coli, making it a remarkably efficient optically mediated antimicrobial agent.
authors.affiliation: Center for Polymers and Organic Solids, Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Center for Polymers and Organic Solids, Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.affiliation: Center for Polymers and Organic Solids, Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Mikhailovsky
authors.affiliation: Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Center for Polymers and Organic Solids, Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
authors.forename: Guillermo C
authors.identifier: 0000-0002-2537-0310
authors.initials: GC
authors.lastname: Bazan
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D004573:Electrolytes / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D008051:Lipid Bilayers / Q000378:metabolism*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D004573:Electrolytes; D008051:Lipid Bilayers; D017319:Photosensitizing Agents; D026082:Singlet Oxygen
keywords: biocidal activity; conjugated oligoelectrolyte; membrane intercalating; photodynamic antimicrobial therapy