title: The Relationship of Serum S100B Levels with Infarction Size and Clinical Outcome in Acute Ischemic Stroke Patients.
abstract: BACKGROUND
  S100B protein, which helps nerve development and differentiation, is produced by astrocytes and can be detected in peripheral circulation after brain damage. In this study, we aimed to investigate the relationship between the serum S100B protein level and the infarction volume and clinical outcome and also the early prognostic role of serum S100B protein in patients with ischemic stroke.
  
  
  METHODS
  Fifty patients admitted in the first 24-hour period of acute ischemic stroke were evaluated prospectively, and the findings were compared to those of the controls (n=26). S100B levels of the patients and neurological findings on days 1, 3, and 5 and their functional outcomes on the discharge day and at the first month were recorded by the same examiner.
  
  
  RESULTS
  S100B levels were not affected by sex, age, or concomitant systemic diseases. The maximum levels of S100B were recorded on the 3rdday, and there was a correlation between infarct size and S100B levels. No correlation between the severity of stroke and S100B level was found. There was a poor correlation between the functional outcomes of the patients at the 1stmonth and S100B levels and on the 3rdday.
  
  
  CONCLUSIONS
  The detection of high S100B levels in peripheral circulation after acute ischemic stroke and the correlations of S100B levels with infarct size (good) and disability (poor) imply that S100B protein may be used as a peripheral marker in acute ischemic stroke patients.
authors.affiliation: Bulanık State Hospital, Neurology Clinics, Muş, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Selçuk
authors.affiliation: Bakırköy Dr. Sadi Konuk Education and Research Hospital, Neurology Clinics, İstanbul, Turkey.
authors.forename: Vildan
authors.initials: V
authors.lastname: Yayla
authors.affiliation: Bakırköy Dr. Sadi Konuk Education and Research Hospital, Neurology Clinics, İstanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Çabalar
authors.affiliation: Van Region Training and Research Hospital, Neurology Clinics, Van, Turkey.
authors.forename: Vildan
authors.initials: V
authors.lastname: Güzel
authors.affiliation: Bakırköy Dr. Sadi Konuk Education and Research Hospital, Neurology Clinics, İstanbul, Turkey.
authors.forename: Samiye
authors.initials: S
authors.lastname: Uysal
authors.affiliation: Bakırköy Dr. Sadi Konuk Education and Research Hospital, Biochemistry Clinics, İstanbul, Turkey.
authors.forename: Asuman
authors.initials: A
authors.lastname: Gedikbaşi
keywords: Brain; biological markers; cerebrovascular disorders; prognosis