title: Philadelphia-Like Acute Lymphoblastic Leukemia in Adults.
abstract: OBJECTIVE
  This study aims to provide an overview of the classification, incidence, genomic alterations, and clinical implications of Philadelphia-like Acute Lymphoblastic Leukemia (Ph-like ALL) in adults.
  
  
  RESULTS
  Ph-like ALL is a high-risk subtype of B cell precursor ALL with characteristic genomic alterations in children and adults. A standard approach for diagnosis is missing and currently mainly based on gene expression analysis. The incidence is age depended and highest in adolescents and younger adults (age 16-39) where 19-28% of patients belong to this subtype. Ph-like ALL is associated with persistence of minimal residual disease (MRD) and inferior prognosis. Some genomic alterations respond to specific treatment approaches and provide hope for tailored therapies. Ph-like ALL in adults is an aggressive and high-risk subtype of B cell precursor ALL. Without consensus definition, diagnosis is difficult and current publications highlight the importance of stringent MRD monitoring to guide risk-adapted treatment strategies.
authors.affiliation: Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität (LMU), Marchioninistr. 15, 81377, Munich, Germany. tobias.herold@med.uni-muenchen.de.
authors.forename: Tobias
authors.initials: T
authors.lastname: Herold
authors.affiliation: Department of Medicine II, Goethe University Hospital, Frankfurt, Germany.
authors.forename: Nicola
authors.initials: N
authors.lastname: Gökbuget
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D018365:Neoplasm, Residual / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
keywords: Adults; BCR-ABL1-like ALL; Genetics; Incidence; Ph-like ALL; Prognosis