title: Decreased expression of ALDH5A1 predicts prognosis in patients with ovarian cancer.
abstract: Aldehyde dehydrogenase 5 family, member A1 (ALDH5A1) belongs to the superfamily of aldehyde dehydrogenases (ALDHs). However, the prognostic value of ALDH5A1 in ovarian cancer remains unclear. The aim of this study was to explore the relationship between ALDH5A1 and the prognosis of patients with ovarian cancer (OC). We compared the expression of ALDH5A1 in OC to that innormal controls, using GSE40595 profiling data. Tissue microarray analysis was conducted for192 OC patients, 14 adjacent normal ovary tissues, and 2 normal ovary tissues. Using the "Kaplan-Meier plotter" (KM plotter) database, updated gene expression data and survival information of a total of 1583 OC patients were used to evaluate the prognostic value of ALDH5A1 in OC patients. We found that ALDH5A1 mRNA expression was downregulated in OC patients compared with that innormal tissues. In survival analyses, we found that ALDH5A1 was positively linked to prognosis in patients with OC, particularly in those with serous ovarian cancer (SOC). In addition, high Ctranscription activity of ALDH5A1 was correlated with better overall survival in SOC patients expressing mutatedTP53, but not in those expressing wild-type TP53. In pathological grades II/III, a high mRNA level of ALDH5A1 was associated with improved overall survival. The positive association between ALDH5A1 and prognosis was found not only in early stages(I and II), but also in advanced stages (III and IV) of SOC patients. results indicate that ALDH5A1 is an excellent predictive factor of OC and may play crucial roles in OC progression.
authors.affiliation: a Cancer Biology Research Center, Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Xun
authors.initials: X
authors.lastname: Tian
authors.affiliation: b Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Yingyan
authors.initials: Y
authors.lastname: Han
authors.affiliation: a Cancer Biology Research Center, Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yu
authors.affiliation: c Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Luo
authors.affiliation: a Cancer Biology Research Center, Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.|d Department of Gynecological Oncology , The First Affiliated Hospital of Sun Yat-sen University, Yuexiu , Guangzhou , Guangdong , China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Hu
authors.affiliation: e Department of Obstetrics and Gynecology, Key Laboratory for Molecular Diagnosis of Hubei Province , The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Li
authors.affiliation: a Cancer Biology Research Center, Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Zongyuan
authors.initials: Z
authors.lastname: Yang
authors.affiliation: a Cancer Biology Research Center, Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: a Cancer Biology Research Center, Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Wanqiu
authors.initials: W
authors.lastname: Huang
authors.affiliation: b Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: e Department of Obstetrics and Gynecology, Key Laboratory for Molecular Diagnosis of Hubei Province , The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: b Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei , China.
authors.forename: Ding
authors.initials: D
authors.lastname: Ma
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D018450:Disease Progression; D015536:Down-Regulation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology*; D010053:Ovary / Q000473:pathology; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D050644:Succinate-Semialdehyde Dehydrogenase / Q000378:metabolism*; D046888:Tissue Array Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C493643:ALDH5A1 protein, human; D050644:Succinate-Semialdehyde Dehydrogenase
keywords: Aldehyde dehydrogenase 5 family member A1; Kaplan-Meier plotter; biomarker; ovarian cancer; prediction; prognosis; suvival