title: Saving the sweetness: renal glucose handling in health and disease.
abstract: Glucose homeostasis is highly controlled, and the function of the kidney plays an integral role in this process. The exquisite control of blood glucose relies, in part, on renal glucose filtration, renal glucose reabsorption, and renal gluconeogenesis. Particularly critical to maintaining glucose homeostasis is the renal reabsorption of glucose; with ~162 g of glucose filtered by the kidney per day, it is imperative that the kidney have the ability to efficiently reabsorb nearly 100% of this glucose back in the bloodstream. In this review, we focus on this central process, highlighting the renal transporters and regulators involved in both the physiology and pathophysiology of glucose reabsorption.
authors.affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Blythe D
authors.initials: BD
authors.lastname: Shepard
authors.affiliation: Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland jpluznick@jhmi.edu.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Pluznick
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D005943:Gluconeogenesis; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D007674:Kidney Diseases / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D065608:Renal Reabsorption; D051247:Sodium-Glucose Transport Proteins / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D051246:Glucose Transport Proteins, Facilitative; D051247:Sodium-Glucose Transport Proteins
keywords: glucose reabsorption; glucose transporter 2; proximal tubule; sodium-glucose cotransporter 1; sodium-glucose cotransporter 2