title: Immunotherapy of elderly acute myeloid leukemia: light at the end of a long tunnel?
abstract: Although it is possible to induce remission in the majority of the patients with acute myeloid leukemia (AML), many patients still die due to disease relapse. Immunotherapy is an attractive option. It is more specific. The memory T cells induced by immunotherapy may also provide the long-term tumor immunosurveillance to prevent disease relapse. Although immunotherapy of AML started in the early 1970s, its clinical impact has been disappointing. Recent advances in tumor immunology and immunotherapeutic agents have rekindled interest. Here, we provide a review of the history of AML immunotherapy, discuss why AML is well suited for immunotherapeutic approaches and present the biological obstacles that affect the success of immunotherapy. Finally, we put forward a new paradigm of AML immunotherapy that utilizes a combination of immunotherapeutic agents sequentially to enhance the in vivo tumor immunogenicity and effective priming and propagation of tumor-specific cytotoxic T cells.
authors.affiliation: a Division of Hematology and Oncology , Rhode Island Hospital/Brown University Warren Alpert Medical School , Providence , RI , USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Rafelson
authors.affiliation: a Division of Hematology and Oncology , Rhode Island Hospital/Brown University Warren Alpert Medical School , Providence , RI , USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Reagan
authors.affiliation: a Division of Hematology and Oncology , Rhode Island Hospital/Brown University Warren Alpert Medical School , Providence , RI , USA.
authors.forename: Loren D
authors.initials: LD
authors.lastname: Fast
authors.affiliation: a Division of Hematology and Oncology , Rhode Island Hospital/Brown University Warren Alpert Medical School , Providence , RI , USA.
authors.forename: Seah H
authors.initials: SH
authors.lastname: Lim
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D007951:Leukemia, Myeloid / Q000276:immunology* / Q000628:therapy*; D012074:Remission Induction; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
keywords: 5-azacytidine; AML; immune checkpoint inhibitor; immunotherapy