title: Tight cohesion between glycolipid membranes results from balanced water-headgroup interactions.
abstract: Membrane systems that naturally occur as densely packed membrane stacks contain high amounts of glycolipids whose saccharide headgroups display multiple small electric dipoles in the form of hydroxyl groups. Experimentally, the hydration repulsion between glycolipid membranes is of much shorter range than that between zwitterionic phospholipids whose headgroups are dominated by a single large dipole. Using solvent-explicit molecular dynamics simulations, here we reproduce the experimentally observed, different pressure-versus-distance curves of phospholipid and glycolipid membrane stacks and show that the water uptake into the latter is solely driven by the hydrogen bond balance involved in non-ideal water/sugar mixing. Water structuring effects and lipid configurational perturbations, responsible for the longer-range repulsion between phospholipid membranes, are inoperative for the glycolipids. Our results explain the tight cohesion between glycolipid membranes at their swelling limit, which we here determine by neutron diffraction, and their unique interaction characteristics, which are essential for the biogenesis of photosynthetic membranes.
authors.affiliation: Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, D-14109 Berlin, Germany.|Department of Physics, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany.
authors.forename: Matej
authors.initials: M
authors.lastname: Kanduč
authors.affiliation: Department of Physics, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schlaich
authors.affiliation: Groningen Biomolecular Sciences and Biotechnology (GBB) Institute and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
authors.forename: Alex H
authors.initials: AH
authors.lastname: de Vries
authors.affiliation: Laboratoire de Physiologie Cellulaire et Végétale, CNRS, CEA, INRA, Université Grenoble Alpes, CEA Grenoble, 17 rue des Martyrs, F-38000 Grenoble, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Jouhet
authors.affiliation: Laboratoire de Physiologie Cellulaire et Végétale, CNRS, CEA, INRA, Université Grenoble Alpes, CEA Grenoble, 17 rue des Martyrs, F-38000 Grenoble, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Maréchal
authors.affiliation: Institut Laue-Langevin, 71 avenue des Martyrs, F-38042 Grenoble Cedex 9, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Demé
authors.affiliation: Department of Physics, Freie Universität Berlin, Arnimallee 14, D-14195 Berlin, Germany.
authors.forename: Roland R
authors.initials: RR
authors.lastname: Netz
authors.affiliation: Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, D-14476 Potsdam, Germany.
authors.forename: Emanuel
authors.initials: E
authors.lastname: Schneck
mesh_terms: D038983:Galactolipids / Q000737:chemistry; D006017:Glycolipids / Q000737:chemistry*; D006860:Hydrogen Bonding; D008051:Lipid Bilayers / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D010713:Phosphatidylcholines / Q000737:chemistry; D011312:Pressure; D014867:Water / Q000737:chemistry*
chemical_list: D038983:Galactolipids; D006017:Glycolipids; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; C007388:digalactosyldiacylglycerol; D014867:Water