title: Identification and Assessment of Cardiac Amyloidosis by Myocardial Strain Analysis of Cardiac Magnetic Resonance Imaging.
abstract: We explored the usefulness of myocardial strain analysis on cardiac magnetic resonance imaging (CMR) scans for the identification of cardiac amyloidosis.
  
  
  
  The 61 patients with systemic amyloidosis underwent 3.0-T CMR, including CMR tagging and late-gadolinium enhanced (LGE) imaging. The circumferential strain (CS) of LGE-positive and LGE-negative patients was measured on midventricular short-axis images and compared. Logistic regression modeling of CMR parameters was performed to detect patients with LGE-positive cardiac amyloidosis. Of the 61 patients with systemic amyloidosis 48 were LGE-positive and 13 were LGE-negative. The peak CS was significantly lower in the LGE-positive than in the LGE-negative patients (-9.5±2.3 vs. -13.3±1.4%, P<0.01). The variability in the peak CS time was significantly greater in the LGE-positive than in the LGE-negative patients (46.1±24.5 vs. 21.2±20.1 ms, P<0.01). The peak CS significantly correlated with clinical biomarkers. The sensitivity, specificity, and accuracy of the diagnostic model using CS parameters for the identification of LGE-positive amyloidosis were 93.8%, 76.9%, and 90.2%, respectively.
  
  
  
  Myocardial strain analysis by CMR helped detect LGE-positive amyloidosis without the need for contrast medium. The peak CS and variability in the peak CS time may correlate with the severity of cardiac amyloid deposition and may be more sensitive than LGE imaging for the detection of early cardiac disease in patients with amyloidosis.
authors.affiliation: Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Seitaro
authors.initials: S
authors.lastname: Oda
authors.affiliation: Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Utsunomiya
authors.affiliation: Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakaura
authors.affiliation: Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yuki
authors.affiliation: Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kidoh
authors.affiliation: Department of Central Radiology, Kumamoto University Hospital.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Morita
authors.affiliation: Department of Cardiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Seiji
authors.initials: S
authors.lastname: Takashio
authors.affiliation: Department of Cardiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Megumi
authors.initials: M
authors.lastname: Yamamuro
authors.affiliation: Department of Cardiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Izumiya
authors.affiliation: Department of Cardiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Hirakawa
authors.affiliation: Department of Cardiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ishida
authors.affiliation: Department of Cardiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Tsujita
authors.affiliation: Department of Neurology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Ueda
authors.affiliation: Department of Neurology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Taro
authors.initials: T
authors.lastname: Yamashita
authors.affiliation: Department of Neurology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ando
authors.affiliation: Department of Informative Clinical Sciences, Faculty of Life Sciences, Kumamoto University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hata
authors.affiliation: Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage*; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009206:Myocardium; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D005682:Gadolinium
keywords: Cardiac amyloidosis; Cardiac magnetic resonance imaging; Late-gadolinium enhancement; Myocardial strain