title: Zidovudine continuous infusion in an HIV-infected pregnant woman with a phobia of swallowing pills.
abstract: The authors report the difficulties of preventing mother-to-child transmission in a pregnant HIV-infected woman with a phobia of swallowing pills. After multiple attempts and just as many failures, the authors ended up with cART consisting of small tablets of nevirapine, lamivudine and a continuous intravenous infusion of zidovudine given via an elastomeric pump at home. This case demonstrates the difficulties that HIV physicians can encounter in pregnant women who have difficulties in swallowing tablets. In exceptional circumstances, continuous infusion of zidovudine may be an option, even in an outpatient setting.
authors.affiliation: Department of Clinical Pharmacy, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Matthijs
authors.initials: M
authors.lastname: van Luin
authors.affiliation: Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Gerjanne
authors.initials: G
authors.lastname: Ter Beest
authors.affiliation: Department of Obstetrics, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Lia E
authors.initials: LE
authors.lastname: Wijnberger
authors.affiliation: Department of Medical Microbiology, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Caroline Ma
authors.initials: CM
authors.lastname: Swanink
authors.affiliation: Department of Pharmacy, Radboud University Medical Centre, Nijmegen, the Netherlands.
authors.forename: David M
authors.initials: DM
authors.lastname: Burger
authors.affiliation: Department of Internal Medicine, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Jet H
authors.initials: JH
authors.lastname: Gisolf
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D010698:Phobic Disorders / Q000150:complications*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000821:virology; D016896:Treatment Outcome; D015215:Zidovudine / Q000008:administration & dosage*
chemical_list: D019380:Anti-HIV Agents; D015215:Zidovudine