title: If Neurologists Establish The Diagnosis of Primary Sjogren's Syndrome?
abstract: BACKGROUND
  Neurological involvements were shown in 20% of patients with Primary Sjogren's Syndrome (pSS). Neurological symptoms may be the first signs of pSS in 57% of the cases. In addition, early diagnosis and treatment of neurological disorders may save or improve the quality of life of these cases. There have been reports about the neurologic manifestations of pSS but little is known about the details of neurologically presented cases.
  
  
  METHODS
  In this study, we described 11 pSS patients who presented with neurological manifestations.
  
  
  RESULTS
  Central nervous system (CNS) involvement was recorded in 7 (63.7%) and peripheric nervous system (PNS) involvement in 4 cases (36.4%).
  
  
  CONCLUSIONS
  Our findings regarding the cases with neurological manifestations leading to the diagnosis of pSS suggest that: 1) The frequency of CNS involvement was higher than that of PNS, and the most frequent clinical pictures of CNS involvement are Multiple Sclerosis (MS)-like illnesses and optic neuritis, 2) Guillain Barre Syndrome (GBS) was the most frequent disease of PNS involvement; 3) Mononeuropathy multiplex (MM) might be the first sign of pSS; 4) Neurologists should consider pSS in the differential diagnosis of cases with MS, optic neuritis, GBS and neuropathies of unknown causes including MM; 5) There is an urgent need of therapeutical guidelines for the cases with neurological involvement associated with pSS.
authors.affiliation: Başkent University Faculty of Medicine, Adana Research and Application Center, Department of Neurology, Adana, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Karaca
authors.affiliation: Başkent University Faculty of Medicine, Adana Research and Application Center, Department of Rheumatology, Adana, Turkey.
authors.forename: Emine Duygu
authors.initials: ED
authors.lastname: Ersözlü Bozkirli
authors.affiliation: Başkent University Faculty of Medicine, Adana Research and Application Center, Department of Neurology, Adana, Turkey.
authors.forename: Başak
authors.initials: B
authors.lastname: Karakurum Göksel
authors.affiliation: Başkent University Faculty of Medicine, Adana Research and Application Center, Department of Neurology, Adana, Turkey.
authors.forename: Meliha
authors.initials: M
authors.lastname: Tan
authors.affiliation: Başkent University Faculty of Medicine, Department of Rheumatology, Ankara, Turkey.
authors.forename: Ahmet Eftal
authors.initials: AE
authors.lastname: Yücel
keywords: Primary Sjogren’s syndrome (pSS); central nervous system (CNS); neurological manifestations; peripheral nervous system (PNS)