title: 4-Anilino-pyrimidine, novel aldosterone synthase (CYP11B2) inhibitors bearing pyrimidine structures.
abstract: 2,2,2-Trifluoro-1-{4-[(4-fluorophenyl)amino]pyrimidin-5-yl}-1-[1-(methylsulfonyl)piperidin-4-yl]ethanol 1 was identified as a novel potent aldosterone synthase inhibitor. Despite large species differences, compound 1 inhibits both human and rodent CYP11B2 in a nano-molar range.
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan. Electronic address: meguro.masaki.i2@daiichisankyo.co.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Meguro
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyauchi
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kanao
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Naito
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Inoue
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Yamada
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Homma
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Chiba
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Futoshi
authors.initials: F
authors.lastname: Nara
authors.affiliation: Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8110, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Furuzono
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry* / Q000494:pharmacology*; D019405:Cytochrome P-450 CYP11B2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000814:Aniline Compounds; D004791:Enzyme Inhibitors; D011743:Pyrimidines; D019405:Cytochrome P-450 CYP11B2
keywords: Aldosterone; Aldosterone synthase inhibitor; Amino-pyrimidine; CYP11B1; CYP11B2