title: Factors influencing intraocular pressure, corneal thickness and corneal biomechanics after congenital cataract surgery.
abstract: This study aims to compare intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanics among patients with aphakia, patients with primary and secondary pseudophakia and matched controls following congenital cataract surgery and to investigate the factors influencing these variables.
  
  
  
  This study included 36 aphakic eyes, 47 primary pseudophakic eyes and 30 secondary pseudophakic eyes. Thirty-four normal eyes of matched volunteers were recruited for comparisons. Postoperative IOP measured with a Goldmann applanation tonometer (IOPGAT), CCT, corneal hysteresis (CH), corneal resistance factor (CRF) and cornea-compensated IOP (IOPCC) were compared among the groups. Univariate analyses and multiple linear regression analyses were used to investigate the influences of independent factors on IOPGAT, CCT, CH, CRF and IOPCC, considering all the operated eyes as one group.
  
  
  
  IOPGATwas 12.5±0.92, 14.7±1.9, 13.4±2.3 and 15.7±2.0 mm Hg in normal, aphakic, primary pseudophakic and secondary pseudophakic eyes, respectively (p<0.001). CCT was 559.5±42.7, 628.0±61.7, 566.8±35.3 and 585.2±41.1 µm, respectively (p<0.001). CH was 10.87±2.47, 10.42±2.20, 11.84±2.13 and 9.74±1.94 mm Hg, respectively (p=0.019). IOPCCwas 15.91±3.74, 18.40±4.35, 14.58±4.36 and 19.05±4.54 mm Hg, respectively (p<0.001). There was no significant difference in CRF among the groups (p=0.06). Regression analyses revealed that the type of operation was significantly associated with IOPGAT(p=0.04), CCT (p<0.001) and CH (p=0.006).
  
  
  
  IOPGAT, CCT, CH and IOPCCwere significantly different in treated eyes compared with normal eyes after congenital cataract surgery. These variables were primarily affected by the type of surgery. Primary intraocular lens implantation preserved corneal structure and function of the anterior chamber angle.
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Faramarzi
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Sepehr
authors.initials: S
authors.lastname: Feizi
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Maghsoodlou
mesh_terms: D001696:Biomechanical Phenomena; D002386:Cataract / Q000151:congenital*; D002387:Cataract Extraction; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000502:physiology*; D007910:Lenses, Intraocular; D008297:Male; D033401:Microscopy, Acoustic; D011184:Postoperative Period; D012189:Retrospective Studies
keywords: and corneal biomechanics; central corneal thickness; congenital cataract surgery; intraocular pressure