title: Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.
abstract: Application of anxiolytic drug Selank to hippocampal slices increased the amplitude and discharge rate of spontaneous inhibitory postsynaptic currents in rat hippocampal pyramidal CA1 neurons. In some neurons, Selank-induced up-regulation of spontaneous inhibitory postsynaptic currents was preceded by a transient decrease in this activity. In the examined concentration range (1-8 μM), Selank demonstrated no significant dose-dependence.
authors.affiliation: Research Center of Neurology, Moscow, Russia. povarovigor@mail.ru.
authors.forename: I S
authors.initials: IS
authors.lastname: Povarov
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: R V
authors.initials: RV
authors.lastname: Kondratenko
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Derevyagin
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: N F
authors.initials: NF
authors.lastname: Myasoedov
authors.affiliation: Research Center of Neurology, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitsky
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology; D004353:Drug Evaluation, Preclinical; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009842:Oligopeptides / Q000494:pharmacology*; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D009842:Oligopeptides; C100827:TP 7
keywords: Selank; anxiolytic drugs; hippocampus; spontaneous activity