title: A Prospective Study of Anterior Segment Ocular Parameters in Anisometropia.
abstract: OBJECTIVE
  The aim of this study was to investigate the differences in anterior segment ocular parameters in anisometropia >1 D.
  
  
  METHODS
  This study included 202 eyes of 101 subjects ranging from 10 to 40 years of age with anisometropia of 1 D or more. The subjects were divided into groups according to anisomyopia, anisoastigmatism, and anisohypermetropia. After providing informed consent, each patient underwent a detailed ophthalmological examination including cycloplegic refraction, best-corrected visual acuity, cover test, axial length (AL) measurement using A-scan ultrasound biometer, keratometry, anterior chamber depth, and central corneal thickness measurement. For each participant, the eye with greater refractive error was compared to the fellow eye via pairedt-tests. Correlations between parameters were studied using the Pearson correlation coefficient.
  
  
  RESULTS
  The average age of subjects was 21.7 ± 9.3 years. Of 101 subjects, 31 had anisomyopia; 42 had anisohypermetropia; and 28 had anisoastigmatism. A predisposition toward greater myopia in right eyes was noted in anisomyopia (24 of 31 subjects, 77%). The inter-ocular acuity difference was significant in all three groups (p< 0.01). As the degree of anisometropia increased, there was significant positive correlation in the difference in AL in myopes (r = 0.863,p< 0.01) and hypermetropes (r = 0.669,p< 0.01) and the difference in corneal curvature in anisoastigmatism (r = 0.564,p= 0.002) and hypermetropes (r = 0.376,p= 0.014). A significant positive correlation was also present between the anterior chamber depth difference and refractive difference in hypermetropes (r = 0.359,p= 0.020).
  
  
  CONCLUSIONS
  This study showed that anisomyopia is correlated only with anterior chamber differences. Anisohypermetropia is correlated with AL differences as well as corneal curvature difference and anterior chamber depth difference. The amount of anisoastigmatism correlates only with corneal curvature difference.
authors.affiliation: Department of Ophthalmology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Singh
authors.affiliation: Department of Ophthalmology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.
authors.forename: Jolly
authors.initials: J
authors.lastname: Rohatgi
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Kumar
mesh_terms: D000293:Adolescent; D000328:Adult; D015858:Anisometropia / Q000175:diagnosis* / Q000503:physiopathology; D000869:Anterior Eye Segment / Q000000981:diagnostic imaging*; D058452:Axial Length, Eye; D001699:Biometry / Q000379:methods; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology*; D014792:Visual Acuity; D055815:Young Adult
keywords: Anisometropia; Anterior chamber depth; Axial length; Corneal curvature