title: Correlation between SNPs in CDH1 and gastric cancer in Chinese population.
abstract: BACKGROUND
  Many recent studies revealed that the single nucleotide polymorphisms have considerable effects on the susceptibility of cancer, such as prostate cancer, lung cancer and gastric cancer. The E-cadherin, a calcium-dependent transmembrane glycoprotein encoded by CDH1 gene, is critical for epithelial construction, intercellular adhesion and cell migration. Some associations have been reported between single nucleotide polymorphisms and gastric cancer in the Chinese population.
  
  
  OBJECTIVE
  To investigate whether the single nucleotide polymorphism in CDH1 gene is associated with the susceptibility of gastric cancer in the Chinese population.
  
  
  METHODS
  The genotypes of 5 known single nucleotide polymorphisms (rs33935154, rs121964871, rs121964874, rs121964875, rs121964876) were determined in 359 gastric cancer patients and 368 healthy controls. High resolution melting curve detection and sequencing analysis were used in the present study.
  
  
  RESULTS
  There is a statistical significance in the rs121964871 C>G polymorphism between gastric cancer patients and healthy controls (OR=1.769, 95%CI: 1.051-2.976). Elderly male individuals (>50 years of age) carrying this risk factor may be more susceptible to gastric cancer.
  
  
  CONCLUSIONS
  The results indicated that the rs121964871 C>G polymorphism is associated with the susceptibility of gastric cancer in the Chinese population, with some age and sex-dependent tendencies observed.
authors.affiliation: Danyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
authors.forename: Yijin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Danyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
authors.forename: Jintao
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Danyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Wang
authors.affiliation: Danyang Blood Center of Jiangsu Province, Danyang, Jiangsu 212300, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Danyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
authors.forename: Yunjia
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Danyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Danyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Chen
authors.affiliation: Danyang People's Hospital of Jiangsu Province, Danyang, China, Danyang Hospital affiliated to Nantong University, Danyang, Jiangsu 212300, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
keywords: CDH1 gene; Gastric cancer; Single nucleotide polymorphism