title: The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels.
abstract: BACKGROUND
  Diabetes mellitus is closely related to pancreas cancer. In this study we aimed to investigate the effect of hyperglycemia on tumor and inflammation markers, as well as pancreatic exocrine functions.
  
  
  METHODS
  A total of 98 consecutive diabetic patients with poor glycemic control, and 50 healthy controls were included in the study. We measured hsCRP, erythrocyte sedimentation rate (ESR), CA19-9, CEA, amylase and lipase in addition to routine biochemistry tests, before and after euglycemia was achieved.
  
  
  RESULTS
  Fasting blood glucose, HbA1c, CA19-9, CEA, hsCRP, ESR, triglycerides, AST, ALT, GGT, ALP, total cholesterol and LDL-C levels decreased significantly with the regulation of glycemic control. Amylase and lipase levels increased with the regulation of glycemic control. After glycemic control, CA19-9 and CEA levels were still higher, whereas amylase and lipase levels were still lower in the diabetic group compared with the control group. Basal HbA1c showed significant correlation with CA19-9, CEA, amylase and lipase.
  
  
  CONCLUSIONS
  We propose to repeat observations of tumor markers after hyperglycemia is resolved, in order to avoid unnecessary invasive tests. Our data also suggest that pancreatic exocrine function was improved with lowering blood glucose in a short period of time.
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Naim
authors.initials: N
authors.lastname: Ata
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Kürşat
authors.initials: K
authors.lastname: Dal
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Kucukazman
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey, Tel: +90 312 3569000.
authors.forename: Abdullah Ö
authors.initials: AÖ
authors.lastname: Yeniova
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Karakaya
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Unsal
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Dagdeviren
authors.affiliation: Kecioren Training and Research Hospital, Department of Clinical Biochemistry. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Kadir O
authors.initials: KO
authors.lastname: Akın
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Salih
authors.initials: S
authors.lastname: Baser
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Beyan
authors.affiliation: Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey.
authors.forename: Derun T
authors.initials: DT
authors.lastname: Ertugrul
keywords: CA19-9; CEA; Glycemic control; amylase; lipase