title: Eag1 K+Channel: Endogenous Regulation and Functions in Nervous System.
abstract: Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+channel is a member of the voltage-gated K+channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.
authors.affiliation: Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China; Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
authors.forename: Bo
authors.identifier: 0000-0002-9882-7166
authors.initials: B
authors.lastname: Han
authors.affiliation: Center for Life Sciences, National Laboratory Astana and School of Sciences and Technology, Nazarbayev University, Astana 010000, Kazakhstan.
authors.forename: Tursonjan
authors.initials: T
authors.lastname: Tokay
authors.affiliation: Department of Anesthesiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
authors.forename: Shangwei
authors.identifier: 0000-0002-5958-7198
authors.initials: S
authors.lastname: Hou
mesh_terms: D000818:Animals; D051638:Ether-A-Go-Go Potassium Channels / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D009420:Nervous System / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D009435:Synaptic Transmission
chemical_list: D051638:Ether-A-Go-Go Potassium Channels