title: Tofacitinib suppresses disease activity and febrile attacks in a patient with coexisting rheumatoid arthritis and familial Mediterranean fever.
abstract: Familial Mediterranean fever (FMF) is the most common hereditary auto-inflammatory (periodic fever) syndrome, and usually successfully treated with colchicine. However, nearly 5-10% of FMF cases are resistant or intolerant to colchicine and treatment options are highly restricted in these cases. Biologics including anakinra, canakinumab, rilonacept, etanercept, infliximab, interferon-alpha, and tocilizumab are shown to have efficacy to control FMF attacks. Tofacitinib, a Janus kinase (JAK) inhibitor, is an orally administered non-biologic disease modifying anti-rheumatic drug for the treatment of rheumatoid arthritis (RA). Herein we report a female patient with coexisting RA and colchicine resistant FMF whose FMF attacks and disease activity were completely controlled after treatment with tofacitinib, a small-molecule JAK3 inhibitor.
authors.affiliation: Erciyes University, Faculty of Medicine.
authors.forename: Kevser
authors.initials: K
authors.lastname: Gök
authors.affiliation: Erciyes University, Faculty of Medicine.
authors.forename: Gizem
authors.initials: G
authors.lastname: Cengiz
authors.affiliation: Erciyes University, Faculty of Medicine.
authors.forename: Kemal
authors.initials: K
authors.lastname: Erol
authors.affiliation: Erciyes University, Faculty of Medicine.
authors.forename: Salih
authors.initials: S
authors.lastname: Ozgocmen
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010880:Piperidines / Q000627:therapeutic use*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*
chemical_list: D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011758:Pyrroles; C479163:tofacitinib