title: The clinical application of angiostatic therapy in combination with radiotherapy: past, present, future.
abstract: Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiation treatment. The results from past and present clinical trials that explored this combination therapy indeed show encouraging results. However, current findings also show that the combination has variable efficacy and is associated with increased toxicity. This indicates that combining radiotherapy with angiostatic drugs not only holds opportunities but also provides several challenges. In the current review, we provide an update of the most recent insights from clinical trials that evaluated the combination of angiostatic drugs with radiation treatment. In addition, we discuss the outstanding questions for future studies in order to improve the clinical benefit of combining angiostatic therapy with radiation therapy.
authors.affiliation: Department of Medical Oncology, VU University Medical Centre, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.
authors.forename: Lisanne C
authors.initials: LC
authors.lastname: Hamming
authors.affiliation: Department of Radiation Oncology, VU University Medical Centre, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Slotman
authors.affiliation: Department of Medical Oncology, VU University Medical Centre, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.
authors.forename: Henk M W
authors.initials: HMW
authors.lastname: Verheul
authors.affiliation: Department of Radiation Oncology, VU University Medical Centre, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands. v.thijssen@vumc.nl.
authors.forename: Victor L
authors.initials: VL
authors.lastname: Thijssen
mesh_terms: D020533:Angiogenesis Inhibitors / Q000266:history / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000266:history / Q000379:methods* / Q000639:trends*; D002986:Clinical Trials as Topic; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000628:therapy*
chemical_list: D020533:Angiogenesis Inhibitors
keywords: Angiogenesis; Angiostatic drugs; Cancer; Clinical trials; Combination therapy; Radiation