title: The role of Hippo/yes-associated protein signalling in vascular remodelling associated with cardiovascular disease.
abstract: Vascular remodelling is a vital process of a wide range of cardiovascular diseases and represents the altered structure and arrangement of blood vessels. The Hippo pathway controls organ size by regulating cell survival, proliferation and apoptosis. Yes-associated protein (YAP), a transcription coactivator, is a downstream effector of the Hippo pathway. There is growing evidence for the importance of the Hippo/YAP pathway in vascular-remodelling and related cardiovascular diseases. The Hippo/YAP pathway alters extracellular matrix production or degradation and the growth, death and migration of vascular smooth muscle cells and endothelial cells, which contributes to vascular remodelling in cardiovascular diseases such as pulmonary hypertension, atherosclerosis, restenosis, aortic aneurysms and angiogenesis. In this review, we summarize and discuss recent findings about the roles and mechanisms of Hippo/YAP signalling in vascular remodelling and related conditions.
  
  
  
  This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.
authors.affiliation: Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.|Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Jinlong
authors.initials: J
authors.lastname: He
authors.affiliation: Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Qiankun
authors.initials: Q
authors.lastname: Bao
authors.affiliation: Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yan
authors.affiliation: Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liang
authors.affiliation: Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Chunjiong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.|Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, 300070, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Ai
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D000090683:Hippo Signaling Pathway; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D018919:Neovascularization, Physiologic; D010750:Phosphoproteins / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors; D066253:Vascular Remodeling; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D017346:Protein Serine-Threonine Kinases