title: A Noninvasive Score Model for Prediction of NASH in Patients with Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease.
abstract: Aims. To develop a noninvasive score model to predict NASH in patients with combined CHB and NAFLD.Objective and Methods. 65 CHB patients with NAFLD were divided into NASH group (34 patients) and non-NASH group (31 patients) according to the NAS score. Biochemical indexes, liver stiffness, and Controlled Attenuation Parameter (CAP) were determined. Data in the two groups were compared and subjected to multivariate analysis, to establish a score model for the prediction of NASH.Results. In the NASH group, ALT, TG, fasting blood glucose (FBG), M30 CK-18, CAP, and HBeAg positive ratio were significantly higher than in the non-NASH group (P< 0.05). Multivariate analysis showed that CK-18 M30, CAP, FBG, and HBVDNA level were independent predictors of NASH. Therefore, a new model combining CK18 M30, CAP, FBG, and HBVDNA level was established using logistic regression. The AUROC curve predicting NASH was 0.961 (95% CI: 0.920-1.00, cutoff value is 0.218), with a sensitivity of 100% and specificity of 80.6%.Conclusion. A noninvasive score model might be considered for the prediction of NASH in patients with CHB combined with NAFLD.
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin 300170, China; Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin 300170, China; Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin 300170, China; Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China.
authors.forename: Fengmei
authors.identifier: 0000-0002-1313-4169
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology and Hepatology, Tianjin Third Central Hospital, Tianjin 300170, China; Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Han
authors.affiliation: Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China; Molecular Biology Laboratory, Tianjin Third Central Hospital, Tianjin 300170, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jing
authors.affiliation: Department of Pathology, Tianjin Third Central Hospital, Tianjin 300170, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Tianjin Key Laboratory of Artificial Cell, Tianjin 300170, China; Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin 300170, China; Molecular Biology Laboratory, Tianjin Third Central Hospital, Tianjin 300170, China.
authors.forename: Yingtang
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001706:Biopsy; D001786:Blood Glucose; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000473:pathology; D006801:Humans; D053538:Keratin-18 / Q000097:blood; D008099:Liver / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000473:pathology; D011379:Prognosis
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006513:Hepatitis B e Antigens; C488421:KRT18 protein, human; D053538:Keratin-18