title: Association between mortality and blood pressure variability in hypertensive and normotensive elders: A cohort study.
abstract: To evaluate the association between blood pressure variability (BPV) and mortality in the elderly, all blood pressure measurements recorded in a cohort of individuals 65 years and older were collected and the association between BPV coefficient of variation (BPV divided by mean arterial pressure) was calculated. Mortality during a 10-year period was compared between BPV coefficient of variation quartiles. Overall, 39 502 individuals 65 years and older were included in the analysis, of which 31 737 (80.3%) were hypertensive; 12 817 (32.4%) individuals died during the study period. Mortality was lower in the second and third blood pressure quartiles compared with the first quartile in both the normotensive and hypertensive groups. In both normotensive and hypertensive individuals, mortality was higher in the fourth quartile, but it was more pronounced in normotensive individuals (odds ratio, 1.18; 95% confidence interval, 1.06-1.31 in hypertensive individuals vs odds ratio, 1.27; 95% confidence interval, 1.17-1.37 in normotensive individuals). High and low BPV are associated with mortality in both hypertensive and normotensive elders.
authors.affiliation: Department of Geriatrics, Rabin Medical Center, Beilinson campus, Petah, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Avraham
authors.initials: A
authors.lastname: Weiss
authors.affiliation: Department of Geriatrics, Rabin Medical Center, Beilinson campus, Petah, Israel.|Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yichayaou
authors.initials: Y
authors.lastname: Beloosesky
authors.affiliation: Department of Epidemiology and Preventive Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Nira
authors.initials: N
authors.lastname: Koren-Morag
authors.affiliation: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.|Internal Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel.
authors.forename: Alon
authors.identifier: http://orcid.org/0000-0002-6969-4296
authors.initials: A
authors.lastname: Grossman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D001795:Blood Pressure Determination; D018660:Blood Pressure Monitoring, Ambulatory; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000401:mortality* / Q000503:physiopathology*; D008297:Male; D009026:Mortality; D016017:Odds Ratio; D012189:Retrospective Studies
keywords: epidemiology; hypertension in the elderly; hypertension-general