title: Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography.
abstract: BACKGROUND
  We compared factors of inflammation - high sensitivity C-reactive protein (hsCRP) and pentraxin-3 (PTX3), and we explored their relationship with coronary artery disease (CAD). Also, we tested the usefulness of hsCRP and PTX3 in the risk assessment of coronary stenosis development and the diagnostic ability of these biomarkers to detect disease severity.
  
  
  METHODS
  The study group consisted of 93 CAD patients undergoing coronary angiography. Patients were divided into CAD(0), representing subclinical stenosis, and CAD (1-3), representing significant stenosis in one, two or three vessels.
  
  
  RESULTS
  We determined the concentration of lipid status parameters, hsCRP and PTX3. We found significantly lower PTX3 and hsCRP concentrations in CAD(0) than in CAD(1-3) group. Concentration of PTX3 showed an increasing trend with the increasing number of vessels affected. The area under ROC curve (AUC) for the combinations of hsCRP and PTX3 with lipid parameters had useful accuracy for detecting CAD(1-3) patients (AUC=0.770,p<0.001).
  
  
  CONCLUSIONS
  PTX3 is a promising independent diagnostic marker for identifying patients with CAD, and a useful indicator of disease progression. In all the analyses PTX3 showed better performance than hsCRP. A combination of PTX3, hsCRP with the lipid status parameters provides risk stratification of the development of coronary stenosis and better classification than their individual application.
authors.affiliation: Institute for Rehabilitation, Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Vuković-Dejanović
authors.affiliation: Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Serbia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Bogavac-Stanojević
authors.affiliation: Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Serbia.
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasić
authors.affiliation: Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Spasojević-Kalimanovska
authors.affiliation: Institute for Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Serbia.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Kalimanovska-Oštrić
authors.affiliation: Institute for Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: Mirko
authors.initials: M
authors.lastname: Topalović
authors.affiliation: Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Serbia.
authors.forename: Zorana
authors.initials: Z
authors.lastname: Jelić-Ivanović
keywords: coronary artery disease; diagnostic accuracy; high sensitivity C-reactive protein; pentraxin-3