title: The association of weight loss with patient experience and outcomes in a population of patients with type 2 diabetes mellitus prescribed canagliflozin.
abstract: OBJECTIVE
  Type 2 diabetes mellitus (T2DM) is a chronic condition complicated by being overweight or obese. This study used a patient survey to assess health, satisfaction, and diabetes self-management in relation to weight management.
  
  
  METHODS
  A survey including the Current Health Satisfaction Questionnaire, Diabetes Distress Scale, and Diabetes Treatment Satisfaction Questionnaire was administered using an online platform to a sample of 205 patients with T2DM prescribed canagliflozin. Patients were placed into 5 groups based on their self-reported weight change since initiation of canagliflozin: Lost >10 lbs, Lost 5-10 lbs, Lost <5 lbs, No Change, and Gained Weight. One-way ANOVAs, Kruskall-Wallis tests, and multivariable regression were used to explore differences between weight loss groups.
  
  
  RESULTS
  The majority of patients (66.8%) reported losing weight. Compared to other groups, patients who lost >10 lbs were more likely to be engaged in a weight loss program for at least 6 months. Patients in the Lost >10 lbs and Lost 5-10 lbs groups reported the greatest satisfaction with canagliflozin (p<0.05 for both). Multivariable analyses controlling for patient demographic and treatment characteristics revealed that losing >10 lbs was associated with reduced diabetes distress, improved A1c and blood glucose levels, and decreased perceived frequency of hyperglycemia (p<0.05).
  
  
  CONCLUSIONS
  Increased positive patient outcomes, engagement in diabetes self-management, and medication satisfaction were observed among patients who reported weight loss. These findings suggest that a T2DM regimen that includes canagliflozin as part of a weight loss regimen can help improve patient outcomes and experiences with T2DM.
authors.affiliation: Health Analytics, LLC Columbia, MD, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Gerlanc
authors.affiliation: Janssen Scientific Affairs, LLC Titusville, NJ, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cai
authors.affiliation: Health Analytics, LLC Columbia, MD, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Tkacz
authors.affiliation: Janssen Scientific Affairs, LLC Titusville, NJ, USA.
authors.forename: Susan C
authors.initials: SC
authors.lastname: Bolge
authors.affiliation: Health Analytics, LLC Columbia, MD, USA.
authors.forename: Brenna L
authors.initials: BL
authors.lastname: Brady
keywords: SGLT2 inhibitor; T2DM; diabetes self-management; patient outcomes; weight management