title: Efficiency of piezotome-corticision assisted orthodontics in alleviating mandibular anterior crowding-a randomized clinical trial.
abstract: OBJECTIVE
  The aim of this clinical trial was to investigate the duration of mandibular-crowding alleviation with piezotome-corticision orthodontics compared with conventional orthodontics.
  
  
  METHODS
  Single-centre, two-arm parallel group randomized controlled trial.
  
  
  METHODS
  Orthodontic clinic at the University of Connecticut.
  The study was approved by the Institutional Review Board (IRB # 12-0147-2).
  
  
  METHODS
  Forty-one adult subjects from a single centre with more than 5mm of mandibular anterior crowding were randomly allocated using block randomization into experimental and control groups. The experimental group received a corticision procedure with a piezotome on the labial aspect of the mandibular incisors in conjunction to a self-ligation fixed orthodontic appliance. The control group received the self-ligation fixed orthodontic appliance and no corticision. Same archwire sequence (0.014 inch followed by 0.014 × 0.025 inch copper-nickel-titanium) was followed for both groups. Mandibular study casts taken every 4-5 weeks were used to assess changes in the irregularity index by blinded outcome assessors.
  
  
  METHODS
  The time to alignment was calculated in days.
  
  
  RESULTS
  Twenty-nine subjects (16 experimental and 13 control) completed the study. Overall, no significant difference in the time required to correct mandibular crowding with piezotome-corticision assisted (102.1 ± 34.7 days; 95% CI, 83.6 to 120.6) and conventional orthodontics (112 ± 46.2 days; 95% CI, 84-139.9) was observed. No complications with treatment or unintended consequences were observed on any of the subjects.
  
  
  CONCLUSIONS
  A high attrition rate.
  
  
  CONCLUSIONS
  This randomized clinical trial found no evidence that piezotome-corticision assisted orthodontics was more efficient in alleviating mandibular anterior crowding.
  
  
  BACKGROUND
  ClinicalTrials.gov, Identifier: NCT02026258.
  
  
  BACKGROUND
  Division of Orthodontics, University of Connecticut.
  
  
  BACKGROUND
  None.
authors.affiliation: Division of Orthodontics, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine, Farmington, USA.
authors.forename: Flavio
authors.initials: F
authors.lastname: Uribe
authors.affiliation: Division of Orthodontics, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine, Farmington, USA.
authors.forename: Leyla
authors.initials: L
authors.lastname: Davoody
authors.affiliation: Division of Orthodontics, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine, Farmington, USA.
authors.forename: Rana
authors.initials: R
authors.lastname: Mehr
authors.affiliation: Division of Orthodontics, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine, Farmington, USA.
authors.forename: Yasas S N
authors.initials: YSN
authors.lastname: Jayaratne
authors.affiliation: Department of Preventive Dental Science, University of Dammam, Saudi Arabia.
authors.forename: Khalid
authors.initials: K
authors.lastname: Almas
authors.affiliation: Division of Periodontics, Department of Oral Health and Diagnostic Sciences, University of Connecticut School of Dental Medicine, Farmington, USA.
authors.forename: Takanori
authors.initials: T
authors.lastname: Sobue
authors.affiliation: Department of Orthodontics, College of Dentistry, The University of Iowa, USA.
authors.forename: Veerasathpurush
authors.initials: V
authors.lastname: Allareddy
authors.affiliation: Division of Orthodontics, Department of Craniofacial Sciences, University of Connecticut School of Dental Medicine, USA.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Nanda
mesh_terms: D000293:Adolescent; D000328:Adult; D000497:Alloys; D005260:Female; D006801:Humans; D007180:Incisor; D008297:Male; D008310:Malocclusion / Q000628:therapy*; D008334:Mandible / Q000601:surgery*; D009532:Nickel; D016382:Orthodontic Appliance Design; D016910:Orthodontic Brackets; D009969:Orthodontic Wires; D059745:Piezosurgery / Q000379:methods*; D016037:Single-Blind Method; D014025:Titanium; D014087:Tooth Movement Techniques / Q000379:methods*
chemical_list: D000497:Alloys; C040654:titanium nickelide; C013616:nitinol; D009532:Nickel; D014025:Titanium