title: Associations between clinical characteristics and angiotensin-converting enzyme gene insertion/deletion polymorphism in Moroccan population with Type-2 diabetic nephropathy.
abstract: Diabetic nephropathy (DN) is one of the severe complications of Type-2 diabetes mellitus (T2DM) and a major cause of end-stage renal disease in these patients. Results from published studies on the relationship between angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) gene polymorphism and patients with DN are still conflicting. We compared the clinical characteristics and the genotype frequencies of ACE polymorphism in 130 T2DM Moroccan patients with DN and 85 T2DM Moroccan patients without DN (controls) using specific primers in a polymerase chain reaction. The degenerative complications of diabetes were significantly higher in the group with nephropathy. The distribution of the I/D genotypes was in Hardy-Weinberg equilibrium. The D allele was the most frequent allele in the Moroccan population in both groups studied (P = 0.68), however, there was no significant difference between the genotypes in T2DM patients with or without DN (P = 0.78). The ACE gene I/D polymorphism was not associated with an increased risk of DN in the Moroccan population.
authors.affiliation: Human Genome Center, Faculty of Medicine and Pharmacy, University Mohammed V; Department of Medical Genetics, National Institute of Health, Rabat, Morocco.
authors.forename: Maria
authors.initials: M
authors.lastname: Mansouri
authors.affiliation: Department of Nephrology, Dialysis and Kidney Transplantation, Faculty of Medicine and Pharmacy, Ibn Sina Hospital, University Mohammed V, Rabat, Morocco.
authors.forename: Amal
authors.initials: A
authors.lastname: Zniber
authors.affiliation: Human Genome Center, Faculty of Medicine and Pharmacy, University Mohammed V; Department of Medical Genetics, National Institute of Health, Rabat, Morocco.
authors.forename: Lamia
authors.initials: L
authors.lastname: Boualla
authors.affiliation: Department of Nephrology, Dialysis and Kidney Transplantation, Faculty of Medicine and Pharmacy, Ibn Sina Hospital, University Mohammed V, Rabat, Morocco.
authors.forename: Ghizlane
authors.initials: G
authors.lastname: El Badaoui
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Faculty of Medicine and Pharmacy, Ibn Sina Hospital, University Mohammed V, Rabat, Morocco.
authors.forename: Mariam
authors.initials: M
authors.lastname: Benkacem
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Faculty of Medicine and Pharmacy, Ibn Sina Hospital, University Mohammed V, Rabat, Morocco.
authors.forename: Kaoutar
authors.initials: K
authors.lastname: Rifai
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Faculty of Medicine and Pharmacy, Ibn Sina Hospital, University Mohammed V, Rabat, Morocco.
authors.forename: Abdelmjid
authors.initials: A
authors.lastname: Chraibi
authors.affiliation: Department of Nephrology, Dialysis and Kidney Transplantation, Faculty of Medicine and Pharmacy, Ibn Sina Hospital, University Mohammed V, Rabat, Morocco.
authors.forename: Loubna
authors.initials: L
authors.lastname: Benamar
authors.affiliation: Human Genome Center, Faculty of Medicine and Pharmacy, University Mohammed V; Department of Medical Genetics, National Institute of Health, Rabat, Morocco.
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: Sefiani
authors.affiliation: Department of Nephrology, Dialysis and Kidney Transplantation, Faculty of Medicine and Pharmacy, Ibn Sina Hospital, University Mohammed V, Rabat, Morocco.
authors.forename: Rabia
authors.initials: R
authors.lastname: Bayahia
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A