title: Selective mono-alkylation of N-methoxybenzamides.
abstract: We report our latest discovery of norbornene derivative modulated highly mono-selective ortho-C-H activation alkylation reactions on arenes bearing simple mono-dentate coordinating groups. The reaction features the use of readily available benzamides and alkyl halides. During the study, we prepared 30 mono-alkylated aryl amides in good yields with good mono-selectivity. We have also demonstrated that structurally rigid alkenes such as norbornene and its derivatives are a good class of ligand and could be used for future direct C-H functionalizations. The utilization of norbornene type ligands for assistance in C-H activation processes has opened a new window for future molecular design using direct C-H functionalization strategies.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. jhuang@tju.edu.cn.
authors.forename: Zenghua
authors.initials: Z
authors.lastname: Chen
authors.forename: Le'an
authors.initials: L
authors.lastname: Hu
authors.forename: Fanyun
authors.initials: F
authors.lastname: Zeng
authors.forename: Ranran
authors.initials: R
authors.lastname: Zhu
authors.forename: Shasha
authors.initials: S
authors.lastname: Zheng
authors.forename: Qingzhen
authors.initials: Q
authors.lastname: Yu
authors.forename: Jianhui
authors.initials: J
authors.lastname: Huang