title: A Revised Fibrinogen Cutoff Value in the Chinese Disseminated Intravascular Coagulation Scoring System May Provide a Better Prognostic Value for Hematological Malignancies.
abstract: To retrospectively validate the prognostic value of the latest Chinese disseminated intravascular coagulation (DIC) scoring system (CDSS) in hematological malignancies, 260 patients with confirmed hematological malignancies and suspected DIC in West China Hospital between 2011 and 2015 were included in this study. We evaluated via univariate and multivariate analyses the diagnostic biomarkers, and the cutoff levels used in the CDSS, except those for fibrinogen, were found to be valid. In subgroup analyses, the value of fibrinogen was found to be mainly unfit for the acute promyelocytic leukemia group. Forty-six patients (17.7%) had elevated fibrinogen levels (>4 g/L) and tended to have a poor prognosis, and thus we redetermined the cutoff value of fibrinogen (<1 g/L or >4 g/L was defined as abnormal). As a result, all of the markers used in the CDSS had prognostic value (including for the promyelocytic leukemia group); meanwhile, this modification also resulted in a larger area under the receiver operating characteristic curve compared to the CDSS and the International Society on Thrombosis and Haemostasis score. We believe that, with regard to prognosis prediction, this cutoff value modification for fibrinogen is preferable for DIC patients with a tendency toward severe hypofibrinogenemia. However, a multicenter, prospective study is needed to validate this possibility.
authors.affiliation: Department of Hematology and Research Laboratory of Hematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.forename: Ting
authors.initials: T
authors.lastname: Niu
authors.forename: Mengyao
authors.initials: M
authors.lastname: Wang
authors.forename: Jinrong
authors.initials: J
authors.lastname: Yang
authors.forename: Pengpeng
authors.initials: P
authors.lastname: Liu
authors.forename: Yuyao
authors.initials: Y
authors.lastname: Yi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002681:China; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D019337:Hematologic Neoplasms / Q000097:blood* / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012372:ROC Curve; D012016:Reference Values; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D005340:Fibrinogen
keywords: Chinese disseminated intravascular coagulation scoring system; Disseminated intravascular coagulation; Fibrinogen; Hematological malignancy; Prognosis