title: Successful treatment of multidrug-resistantPseudomonas aeruginosapubic symphysis osteomyelitis with ceftolozane/tazobactam.
abstract: New antibiotic options are needed for the treatment of multidrug-resistant (MDR)Pseudomonasinfections. We present a case of a man aged 64 years with a bladder fistula due to radiation, ultimately causing osteomyelitis of the pubic symphysis. Repeated antibiotic courses, without correcting the fistula, resulted in infection with MDRPseudomonas aeruginosa.He was successfully treated for his osteomyelitis through cystectomy, aggressive debridement and a prolonged course of antimicrobials directed at the MDRPseudomonasisolate.
authors.affiliation: Department of Infectious Diseases, VA Western New York Healthcare System, Buffalo VA Medical Center, Buffalo, New York, USA.
authors.forename: Kari E
authors.initials: KE
authors.lastname: Kurtzhalts
authors.affiliation: Department of Infectious Diseases, VA Western New York Healthcare System, Buffalo VA Medical Center, Buffalo, New York, USA.
authors.forename: Kari A
authors.initials: KA
authors.lastname: Mergenhagen
authors.affiliation: Department of Infectious Diseases, VA Western New York Healthcare System, Buffalo VA Medical Center, Buffalo, New York, USA.|State University of New York at Buffalo, Jacob's School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
authors.forename: Akshay
authors.initials: A
authors.lastname: Manohar
authors.affiliation: Department of Infectious Diseases, VA Western New York Healthcare System, Buffalo VA Medical Center, Buffalo, New York, USA.|State University of New York at Buffalo, Jacob's School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Berenson
mesh_terms: D002511:Cephalosporins / Q000008:administration & dosage* / Q000627:therapeutic use; D015653:Cystectomy; D003646:Debridement; D024901:Drug Resistance, Multiple, Bacterial; D005402:Fistula / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011631:Pubic Symphysis / Q000601:surgery*; D000078142:Tazobactam; D016896:Treatment Outcome
chemical_list: D002511:Cephalosporins; C000594038:ceftolozane, tazobactam drug combination; D010397:Penicillanic Acid; D000078142:Tazobactam