title: From bench to bedside: Therapeutic potential of interleukin-9 in the treatment of asthma.
abstract: Initially identified as a T cell and mast cell growth factor, interleukin (IL)-9 has long been recognized as an important mediator of asthma. Recently, accumulating results from transgenic mice demonstrated that systemic or lung-specific overexpression of IL-9 caused asthma-associated symptoms. Moreover, anti-mIL-9 antibody (Ab) blocking treatment alleviated disease in animal models of asthma. In light of the large quantity of data from the murine models, MEDI-528, a humanized anti-IL-9 monoclonal Ab has been produced to assess the activity of IL-9 on human asthma. In order to ascertain whether it is a successful translation from bench to bedside, the biological features of IL-9 were evaluated and up-to-date information regarding the role of IL-9 in different experimental murine models and human asthma were summarized.
authors.affiliation: Department of Respiratory Medicine, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Gong
authors.affiliation: Department of Respiratory Medicine, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China.
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Pan
authors.affiliation: Department of Respiratory Medicine, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Respiratory Medicine, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China.
authors.forename: Hua-Yan
authors.initials: HY
authors.lastname: Zhu
authors.affiliation: Department of Respiratory Medicine, The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu 214041, P.R. China.
authors.forename: Dong-Lin
authors.initials: DL
authors.lastname: Jiang
keywords: allergic inflammation; asthma; interleukin-9; interleukin-9 receptor; treatment