title: Use of Sitagliptin With Closed-Loop Technology to Decrease Postprandial Blood Glucose in Type 1 Diabetes.
abstract: Postprandial hyperglycemia poses a challenge to closed-loop systems. Dipeptidyl peptidase-4 (DPP-4) inhibitors, like sitagliptin, reduce postprandial glucose concentrations in patients with type 2 diabetes. The objective of this study was to assess sitagliptin's role in type 1 diabetes (T1DM) as an adjunct therapy in reducing postprandial blood glucose with an insulin-only closed-loop system.
  
  
  
  This was a randomized, double-blinded, placebo controlled, crossover design trial. The participants were18-35 years old, had T1DM, and an HbA1c of ≤ 8.5%. A dose determination study included eight subjects with T1DM. There were three study visits. Four hours after receiving study drug (placebo, sitagliptin 50 mg, sitagliptin 100 mg), subjects underwent a mixed meal tolerance test with assessment of hormone concentrations. In a second study, 15 subjects underwent two visits receiving either placebo or 100 mg of sitagliptin plus an insulin only closed-loop system for 25 hours with timed meals. Blood glucose and other hormone concentrations were analyzed using repeated measures ANOVA.
  
  
  
  For the dose determination study, sitagliptin 100 mg resulted in reduced postprandial blood glucose ( P = .006). For the closed-loop study, glucose concentrations were lower in the treatment group, most prominently during the first two study meals ( P = .03). There was no difference in glucagon concentrations, but insulin concentrations and insulin delivery were lower in the treatment group.
  
  
  
  Sitagliptin may be considered as an adjunct therapy in a closed-loop setting. Larger studies are needed to determine the role of oral agents like sitagliptin to lower postprandial hyperglycemia with closed loop.
authors.affiliation: 1 Department of Pediatrics, Division of Endocrinology and Diabetes, Children's Hospital at Montefiore, Bronx, NY, USA.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Underland
authors.affiliation: 1 Department of Pediatrics, Division of Endocrinology and Diabetes, Children's Hospital at Montefiore, Bronx, NY, USA.|2 Department of Pediatrics, Division of Diabetes, NYU Lagone Medical Center, New York, NY USA.
authors.forename: Jeniece Trast
authors.initials: JT
authors.lastname: Ilkowitz
authors.affiliation: 1 Department of Pediatrics, Division of Endocrinology and Diabetes, Children's Hospital at Montefiore, Bronx, NY, USA.
authors.forename: Ranjitha
authors.initials: R
authors.lastname: Katikaneni
authors.affiliation: 1 Department of Pediatrics, Division of Endocrinology and Diabetes, Children's Hospital at Montefiore, Bronx, NY, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Dowd
authors.affiliation: 1 Department of Pediatrics, Division of Endocrinology and Diabetes, Children's Hospital at Montefiore, Bronx, NY, USA.
authors.forename: Rubina A
authors.initials: RA
authors.lastname: Heptulla
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000187:drug effects*; D018592:Cross-Over Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000008:administration & dosage; D007332:Insulin Infusion Systems; D008297:Male; D019518:Postprandial Period / Q000187:drug effects; D000068900:Sitagliptin Phosphate / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D000068900:Sitagliptin Phosphate
keywords: artificial pancreas; closed loop; sitagliptin; type 1 diabetes