title: Brief communication: MRGPRX2, atopic dermatitis and red man syndrome.
abstract: Vancoymycin causes red man syndrome, an itchy erythematous eruption involving the face, neck and upper torso. Atopic dermatitis also manifests itch and erythema, and staphylococcus δ-toxin contributes to this process. The antibiotic and toxin each provoke mast cell degranulation but the mechanism had not been understood. We have determined that these compounds evoke degranulation via interaction with the same receptor, MRGPRX2, on mast cells. A receptor antagonist inhibits this process. Antagonists of this receptor may have therapeutic potential.
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, 149, 13th Street, Charlestown, MA 02129 USA.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Azimi
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, 149, 13th Street, Charlestown, MA 02129 USA.
authors.forename: Vemuri B
authors.initials: VB
authors.lastname: Reddy
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, 149, 13th Street, Charlestown, MA 02129 USA.
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Lerner