title: Catalytic Enolate Arylation with 3-Bromoindoles Allows the Formation of β-Carbolines.
abstract: Synthesis of substituted β-carbolines was accomplished by utilizing the catalytic enolate arylation reaction of ketones in conjunction with several 3-bromoindole derivatives. Quenching of the arylation reaction in situ with an electrophile allowed ready incorporation of functionality at the carboline C-4 position in an efficient one-pot protocol.
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: C Henrique
authors.initials: CH
authors.lastname: Alves Esteves
authors.affiliation: AstraZeneca, Pharmaceutical Sciences , Silk Road Business Park, Macclesfield SK10 2NA, U.K.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Smith
authors.affiliation: Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford OX1 3TA, U.K.
authors.forename: Timothy J
authors.identifier: 0000-0001-7088-6626
authors.initials: TJ
authors.lastname: Donohoe