title: New insights into mononuclear phagocyte biology from the visual system.
abstract: Major advances in mononuclear phagocyte biology have been made but key questions pertinent to their roles in health and disease remain, including in the visual system. One problem concerns how dendritic cells can trigger immune responses from certain tightly regulated immune- privileged sites of the eye. Another, albeit separate, problem involves whether there are functional specializations for microglia versus monocytes in retinal neurodegeneration. In this Review, we examine novel insights in eye immune privilege and, separately, we discuss recent inroads concerning retinal degeneration. Both themes have been extensively studied in the visual system and show parallels with recent findings concerning mononuclear phagocytes in the central nervous system and in the periphery.
authors.affiliation: Duke University School of Medicine, Duke Eye Center, Department of Ophthalmology, 2351 Erwin Road, Durham, North Carolina 27705, USA.
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Reyes
authors.affiliation: Duke University School of Medicine, Duke Eye Center, Department of Ophthalmology, 2351 Erwin Road, Durham, North Carolina 27705, USA.
authors.forename: Emily G
authors.initials: EG
authors.lastname: O'Koren
authors.affiliation: Duke University School of Medicine, Duke Eye Center, Department of Ophthalmology, 2351 Erwin Road, Durham, North Carolina 27705, USA.|Duke University School of Medicine, Department of Immunology, 207 Research Drive, Durham, North Carolina 27710, USA.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Saban
mesh_terms: D000818:Animals; D005123:Eye / Q000166:cytology / Q000276:immunology*; D006801:Humans; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D012160:Retina / Q000166:cytology / Q000276:immunology; D014796:Visual Perception