title: Clinical study on the efficacy of Amoebex (coded herbal drug) compared with Metronidazole for the treatment of Amoebic dysentery.
abstract: Amoebiasisis an infectious disease, which originated with the single-celled parasitic protozoan Entamoeba histolytica. The parasitic amoeba infects the liver and intestine and may cause mild diarrhea and serious dysentery with bloody and mucoid stool. A study was conducted to evaluate the efficacy of Amoebex (400mg), a herbal formulation for the treatment of amoebiasis infections as compared to that of Metronidazole (400mg). The therapeutic evaluations of these medicines were carried out on 184 clinically diagnosed cases of the amoebiasis infection. Sample sizes of Ameobex for this study included a total of 93 patients and for Metronidazole a total of 91 were registered and treated. Comparison of the data recorded for the participants relating to sign and symptoms variables showed significant differences of efficacy between test and control groups (p<0.0357) and no side effects were at all recorded in test group. According to observation, there was a difference in the overall clinical success of both treatment groups, however, the efficacy of the test treated medication (Amoebex) was superior to that of Metronidazole as (p<0.03), and on the basis of the statistical analysis done by the chi square test, the null hypothesis was rejected. `It is clearly evident that Amoebex possesses therapeutic value for the treatment of amoebiasis associated symptoms but also the eradication rate of amoebiasis is superior by Amoebex as compared to that of Metronidazole (Control drug).
authors.affiliation: Department of Eastern Medicine and Surgery, Govt. College University, Faisalabad, Pakistan.
authors.forename: Syed MuhammadAli
authors.initials: SM
authors.lastname: Shah
authors.affiliation: Department of Basic Clinical Sciences, Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan.
authors.forename: Khan
authors.initials: K
authors.lastname: Usmanghani
authors.affiliation: Faculty of Pharmacy, Islamia University of Bahawalpur, Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Akhtar
authors.affiliation: Department of Eastern Medicine and Surgery, The University of The Poonch, Rawalakot, Azad Jammu & Kashmir, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Akram
authors.affiliation: Department of Eastern Medicine and Surgery, The University of The Poonch, Rawalakot, Azad Jammu & Kashmir, Pakistan.
authors.forename: Hafiz Muhammad
authors.initials: HM
authors.lastname: Asif
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
authors.forename: Muhammad Mohtasheemul
authors.initials: MM
authors.lastname: Hasan
mesh_terms: D000293:Adolescent; D000328:Adult; D000563:Amebicides / Q000009:adverse effects / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D004404:Dysentery, Amebic / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D010154:Pakistan; D028321:Plant Preparations / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000563:Amebicides; D028321:Plant Preparations; D008795:Metronidazole