title: Superbanone, A New 2-Aryl-3-benzofuranone and Other Bioactive Constituents from the Tube Roots of Butea superba.
abstract: Phytochemical investigation from the tube roots of Butea superba, led to the isolation and identification of a new 2-aryl-3-benzofuranone named superbanone (1), one benzoin, 2-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)ethanone (2), eight pterocarpans (3 - 10), and eleven isoflavonoids (11 - 21). Compound 2 was identified for the first time as a natural product. The structure of the isolated compounds was elucidated using spectroscopic methods, mainly 1D- and 2D-NMR. The isolated compounds and their derivatives were evaluated for α-glucosidase inhibitory and antimalarial activities. Compounds 3, 7, 8, and 11 showed promising α-glucosidase inhibitory activity (IC50= 13.71 ± 0.54, 23.54 ± 0.75, 28.83 ± 1.02, and 12.35 ± 0.36 μm, respectively). Compounds 3 and 11 were twofold less active than the standard drug acarbose (IC50= 6.54 ± 0.04 μm). None of the tested compounds was found to be active against Plasmodium falciparum strain 94. On the basis of biological activity results, structure-activity relationships are discussed.
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand.
authors.forename: Jutatip
authors.initials: J
authors.lastname: Boonsombat
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand.
authors.forename: Vilailak
authors.initials: V
authors.lastname: Prachyawarakorn
authors.affiliation: School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai, 57100, Thailand.
authors.forename: Acharavadee
authors.initials: A
authors.lastname: Pansanit
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand.|Chulabhorn Graduate Institute and Center for Environmental Health and Toxicology, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand.
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand.|Chulabhorn Graduate Institute and Center for Environmental Health and Toxicology, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand.
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok, 10210, Thailand.
authors.forename: Sanit
authors.initials: S
authors.lastname: Thongnest
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000302:isolation & purification* / Q000494:pharmacology; D001573:Benzoin / Q000302:isolation & purification; D031290:Butea / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D036343:Pterocarpans / Q000302:isolation & purification; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D001572:Benzofurans; D005419:Flavonoids; D065089:Glycoside Hydrolase Inhibitors; D036343:Pterocarpans; D001573:Benzoin
keywords: 
  Butea superba
  ; Antimalarial activities; Benzofuranone; Pterocarpan; α-Glucosidase inhibitor