title: Association betweenRTEL1gene polymorphisms and COPD susceptibility in a Chinese Han population.
abstract: OBJECTIVE
  We investigated the association between single-nucleotide polymorphisms in regulation of telomere elongation helicase 1 (RTEL1), which has been associated with telomere length in several brain cancers and age-related diseases, and the risk of chronic obstructive pulmonary disease (COPD) in a Chinese Han population.
  
  
  METHODS
  In a case-control study that included 279 COPD cases and 290 healthy controls, five single-nucleotide polymorphisms inRTEL1were selected and genotyped using the Sequenom MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression after adjusting for age and gender.
  
  
  RESULTS
  In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10-0.82;P=0.02). In the genetic model analysis, we found that the "C/C" genotype of rs4809324 was associated with a decreased risk of COPD based on the codominant model (OR =0.33; 95% CI =0.13-0.86;P=0.022) and recessive model (OR =0.32; 95% CI =0.12-0.80;P=0.009).
  
  
  CONCLUSIONS
  Our data shed new light on the association between genetic polymorphisms ofRTEL1and COPD susceptibility in the Chinese Han population.
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Heping
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Jinjian
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Dongchuan
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: He
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Shengyang
authors.initials: S
authors.lastname: Yi
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Quanni
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Yuanshui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Cibing
authors.initials: C
authors.lastname: Wu
authors.affiliation: Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
authors.forename: Zhongjie
authors.initials: Z
authors.lastname: Tian
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D004265:DNA Helicases / Q000235:genetics*; D005260:Female; D005541:Forced Expiratory Volume; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: C532890:RTEL1 protein, human; D004265:DNA Helicases
keywords: COPD; RTEL1; association study; case-control study; chronic obstructive pulmonary disease; gene polymorphisms