title: Central Hyperthermia Treated with Bromocriptine.
abstract: Introduction. Central hyperthermia is common in patients with brain injury. It typically has a rapid onset with high temperatures and marked fluctuations and responds poorly to antibiotics and antipyretics. It is also associated with worse outcomes in the brain injured patient. Recognizing this, it is important to aggressively manage it.Case Report. We report a 34-year-old male with a right thalamic hemorrhage extending to the midbrain and into the ventricles. During his admission, he developed intractable fevers with core temperatures as high as 39.3°C. Infectious workup was unremarkable. The fever persisted despite empiric antibiotics, antipyretics, and cooling wraps. Bromocriptine was started resulting in control of the central hyperthermia. The fever spikes were reduced to minor fluctuations that significantly worsened with any attempt to wean off the bromocriptine.Conclusion. Diagnosing and managing central hyperthermia can be challenging. The use of bromocriptine can be beneficial as we have reported.
authors.affiliation: Department of Neurology, University of Missouri, 5 Hospital Drive, CE 540, Columbia, MO 65211, USA.
authors.forename: P
authors.initials: P
authors.lastname: Natteru
authors.affiliation: Department of Neurology, Cerebrovascular Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44125, USA.
authors.forename: P
authors.initials: P
authors.lastname: George
authors.affiliation: Department of Surgery, Division of Neurosurgery, University of Missouri, 1 Hospital Drive, Columbia, MO 65211, USA.
authors.forename: R
authors.initials: R
authors.lastname: Bell
authors.affiliation: Department of Neurology, University of Missouri, 5 Hospital Drive, CE 540, Columbia, MO 65211, USA.
authors.forename: P
authors.initials: P
authors.lastname: Nattanmai
authors.affiliation: Department of Neurology, University of Missouri, 5 Hospital Drive, CE 540, Columbia, MO 65211, USA.
authors.forename: C R
authors.identifier: 0000-0002-9386-7791
authors.initials: CR
authors.lastname: Newey