title: Obesity induction in hamster that mimics the human clinical condition.
abstract: Although obesity is well established in hamsters, studies using diets with high levels of simple carbohydrate associated with lipids are necessary to assess the impact of this type of food in the body. In this study a high sugar and butter diet (HSB) and high temperature were employed towards this end. Obesity was successfully induced at a temperature of 30.3°C to 30.9°C after 38 days feeding the animals an HSB diet. It was shown that although diet is important for the induction of obesity, temperature is also essential because at a temperature slightly below the one required, obesity was not induced, even when the animals were fed for a longer period (150 days).The obese clinical condition was accompanied by biochemical and hematological changes, as increased cholesterol and triglyceride levels and increased leukocyte numbers, similar to alterations observed in obese humans. Furthermore, it was demonstrated that increasing the intake of simple carbohydrates associated with lipids provided evidence of inflammation in obese animals.
authors.affiliation: Molecular Parasitology Laboratory, Parasitology Department, Institute of Biological Sciences, Federal University of Minas Gerais. Antônio Carlos Ave, 6627, Pampulha. CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.|Center University UNA, Guajajaras St, 175, Center. CEP 30180-100, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Vivian
authors.initials: V
authors.lastname: Jordania da Silva
authors.affiliation: Molecular Parasitology Laboratory, Parasitology Department, Institute of Biological Sciences, Federal University of Minas Gerais. Antônio Carlos Ave, 6627, Pampulha. CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.|Center University Estácio Juiz de Fora, Av. Presidente João Goulart, 600, Cruzeiro do Sul. CEP 36030-900. Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Sílvia Regina Costa
authors.initials: SRC
authors.lastname: Dias
authors.affiliation: Nutrition Department, Nursering School, Federal University of Minas Gerais. Alfredo Balena Ave, 190, Santa Efigênia, CEP 30130-100.
authors.forename: Tatiani Uceli
authors.initials: TU
authors.lastname: Maioli
authors.affiliation: Molecular Parasitology Laboratory, Parasitology Department, Institute of Biological Sciences, Federal University of Minas Gerais. Antônio Carlos Ave, 6627, Pampulha. CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Luciana Ribeiro
authors.initials: LR
authors.lastname: Serafim
authors.affiliation: Molecular Parasitology Laboratory, Parasitology Department, Institute of Biological Sciences, Federal University of Minas Gerais. Antônio Carlos Ave, 6627, Pampulha. CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Luis Fernando Viana
authors.initials: LFV
authors.lastname: Furtado
authors.affiliation: Center University UNA, Guajajaras St, 175, Center. CEP 30180-100, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Maria da Gloria
authors.initials: MDG
authors.lastname: Quintão Silva
authors.affiliation: Biochemistry and Immunology Department, Institute of Biological Sciences, Federal University of Minas Gerais, Antônio Carlos Ave, 6627, Pampulha. CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Ana Maria Caetano de
authors.initials: AMC
authors.lastname: Faria
authors.affiliation: Molecular Parasitology Laboratory, Parasitology Department, Institute of Biological Sciences, Federal University of Minas Gerais. Antônio Carlos Ave, 6627, Pampulha. CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Élida Mara Leite
authors.initials: ÉML
authors.lastname: Rabelo
mesh_terms: D000818:Animals; D002079:Butter; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000009:adverse effects*; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism; D007958:Leukocyte Count; D009765:Obesity / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D013696:Temperature; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D014280:Triglycerides; D002079:Butter; D002784:Cholesterol
keywords: AIN-93; hamster; high sugar and butter diet; obesity; temperature