title: Dataset of the human homologues and orthologues of lipid-metabolic genes identified as DAF-16 targets their roles in lipid and energy metabolism.
abstract: The data presented in this article are related to the review article entitled 'Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis' (Saavedra-Garcia et al., 2017) [24]. Here, we have matched the DAF-16/FOXO3 downstream genes with their respective human orthologues and reviewed the roles of these targeted genes in FA metabolism. The list of genes listed in this article are precisely selected from literature reviews based on their functions in mammalian FA metabolism. The nematodeCaenorhabditis elegansgene orthologues of the genes are obtained from WormBase, the online biological database ofC. elegans.This dataset has not been uploaded to a public repository yet.
authors.affiliation: Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.
authors.forename: Lavender Yuen-Nam
authors.initials: LY
authors.lastname: Fan
authors.affiliation: Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.
authors.forename: Paula
authors.initials: P
authors.lastname: Saavedra-García
authors.affiliation: Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK.
authors.forename: Eric Wing-Fai
authors.initials: EW
authors.lastname: Lam
keywords: ACAA2, Acetyl-CoA acetyltransferase 2; ACACA, Acetyl-CoA carboxylase; ACAD8, Acyl-CoA dehydrogenase family member 8; ACADM, Acyl-CoA dehydrogenase C4 to C12 straight chain; ACOX, Acyl-CoA oxidase; ACSL3/4, Acyl-CoA synthetase long-chain family member 3/4; ACSS, Acyl-CoA synthetase short-chain family member; CPT2, Carnitine palmitoyltransferase II; Caenorhabditis elegans; DAF-16; DAG, Diacylglycerol; DGAT, Diacylglycerol O-acyltransferase; ECHS1, Short-chain enoyl-CoA hydratase 1; ELOVL1, Elongation of very long chain fatty acids protein 1; FA, fatty acid; FADS2, Fatty acid desaturase 2; FASN, Fatty acid synthase; FATP4, Fatty acid transport protein 4; FOX, Forkhead box; FOXM1; FOXO3; HADH, Hydroxyacyl-coenzyme A dehydrogenase; HADHA, Hydroxyacyl-CoA dehydrogenase/3-Ketoacyl-CoA thiolase/Enoyl-CoA hydratase, alpha subunit; LCFA, Long chain fatty acid; Lipid metabolism; MLYCD, Malonyl-CoA decarboxylase; MOGAT1/2, Monoacylglycerol O-acyltransferase 1/2; PNPLA, patatin like phospholipase domain containing; PUFA, polyunsaturated fatty acid; SCD1/5, Stearoyl-CoA desaturase 1/5; TAG, triacylglycerol; TCA, Tricarboxylic acid; VLCFA, Very long chain fatty acid.