title: Narrow-band imaging in transoral laser surgery for early glottic cancer in relation to clinical outcome.
abstract: The purpose of this study was to validate the prognostic value of adding narrow-band imaging (NBI) during transoral laser surgery (TLS) for early glottic cancer.
  
  
  
  In 84 patients, 93 transoral laser resections were performed for carcinoma in situ (Tcis), T1, or T2 glottic cancer. TLS was preceded by intraoperative evaluation using traditional white-light imaging (WLI) in 51 cases. In 42 cases, NBI was used in addition to WLI. Local recurrence rate and recurrence-free survival were retrospectively compared between both groups.
  
  
  
  Local recurrences developed in 14% of the 93 cases: 12 of 51 patients (24%) were treated by TLS based on WLI alone, and in 1 of 42 patients (2%) in the NBI group (P < .01). Two-year recurrence-free survival was 82% in the WLI group and 98% in the NBI group (P < .05).
  
  
  
  Additional use of NBI during TLS for early glottic cancer significantly improves clinical outcome.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Boudewijn E C
authors.initials: BEC
authors.lastname: Plaat
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Manon A
authors.initials: MA
authors.lastname: Zwakenberg
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Joost G
authors.initials: JG
authors.lastname: van Zwol
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Wedman
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Bernard F A M
authors.initials: BFAM
authors.lastname: van der Laan
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: György B
authors.initials: GB
authors.lastname: Halmos
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, The Netherlands.
authors.forename: Frederik G
authors.initials: FG
authors.lastname: Dikkers
mesh_terms: D000368:Aged; D016009:Chi-Square Distribution; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D062048:Narrow Band Imaging / Q000379:methods*; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D009426:Netherlands; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: laryngeal cancer; narrow-band imaging (NBI); transoral laser surgery