title: Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder.
abstract: The recent advent of induced pluripotent stem cells has enabled the study of patient-specific and disease-related neurons in vitro and has facilitated new directions of inquiry into disease mechanisms. With these approaches, we now have the possibility of correlating ex vivo cellular phenotypes with individual patient response to treatment and/or side effects, which makes targeted treatments for schizophrenia and bipolar disorder a distinct prospect in the coming years. Here, we briefly review the current state of stem cell-based models and explore studies that are providing new insights into the disease biology of schizophrenia and bipolar disorder, which are laying the foundations for the development of novel targeted therapies.
authors.affiliation: Center for Experimental Drugs & Diagnostics, Psychiatric & Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Harvard Medical School & Massachusetts General Hospital, Boston, MA 02114, USA.|Chemical Biology Program, Broad Institute of Harvard & MIT, Cambridge, MA 02142, USA.
authors.forename: Bradley
authors.initials: B
authors.lastname: Watmuff
authors.affiliation: Center for Experimental Drugs & Diagnostics, Psychiatric & Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Harvard Medical School & Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Bangyan
authors.initials: B
authors.lastname: Liu
authors.affiliation: Center for Experimental Drugs & Diagnostics, Psychiatric & Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Harvard Medical School & Massachusetts General Hospital, Boston, MA 02114, USA.|Chemical Biology Program, Broad Institute of Harvard & MIT, Cambridge, MA 02142, USA.|Schizophrenia & Bipolar Disorder Program, McLean Hospital, Belmont, MA 02478, USA.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Karmacharya
mesh_terms: D001714:Bipolar Disorder / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology / Q000637:transplantation*; D009474:Neurons / Q000502:physiology / Q000637:transplantation*; D012559:Schizophrenia / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
keywords: bipolar disorder; disease modeling; drug development; drug screening; human-induced pluripotent stem cells; iPSC; personalized medicine; schizophrenia; targeted treatments