title: Immediate implant and rehabilitation based on All-on-4 concept in patients with generalized aggressive periodontitis: A medium-term prospective study.
abstract: BACKGROUND
  Aggressive periodontitis renders a great challenge to the conventional implant due to the risks of infection and ongoing marginal bone loss (MBL). A study about full-arch immediate implant and restoration in patients with advanced generalized aggressive periodontitis (GAP) was not read, even though the All-on-4 concept has been proven to be predictable for edentulous patients.
  
  
  OBJECTIVE
  This prospective study aimed to evaluate the feasibility and medium-term outcomes of immediate implant and rehabilitation based on the All-on-4 concept in patients with advanced GAP via clinical and radiographic analyses.
  
  
  METHODS
  Seventeen patients (mean age 39.4 years) with advanced GAP received immediate postextraction implant and rehabilitation based on the All-on-4 concept between January 2009 and January 2014. Eighty implants were inserted into 20 arches (7 maxillae and 13 mandibles). The average follow-up duration was 5 years (range 2-7). Complications, probing depth, and plaque, bleeding, and gingiva indices were evaluated. MBL was measured based on the panoramic radiographs taken immediately after surgery and annually thereafter.
  
  
  RESULTS
  The cumulative survival rate (CSR) of the implants was 98.75% (79/80) after an average of 5 years. One tilted implant failed due to peri-implantitis. The average peri-implant MBL was 0.8 ± 0.4 and 1.2 ± 0.3 mm after 1 and 7 years, respectively. The CSR was 100% (20/20) for definite prostheses, while 85% (17/20) for provisional prostheses. The average probing depth, and plaque, bleeding, and gingiva indices at the last recall visit were 3.0 ± 0.5, 1.2 ± 0.4, 0.5 ± 0.5, and 0.4 ± 0.4 mm, respectively. Patient showed high satisfaction to the overall effects.
  
  
  CONCLUSIONS
  Based on this study, the All-on-4 concept provided predictable outcomes in patients with GAP in 2- to 7-year follow-ups, and averted the severe bone defect area of aggressive periodontitis.
authors.affiliation: Department of Oral Implantology, School and Hospital of Stomatology, Peking University, Beijing, People's Republic of China.
authors.forename: Sha
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Oral Implantology, School and Hospital of Stomatology, Peking University, Beijing, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Di
authors.affiliation: Department of Oral Implantology, School and Hospital of Stomatology, Peking University, Beijing, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oral Implantology, School and Hospital of Stomatology, Peking University, Beijing, People's Republic of China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000175:diagnosis / Q000534:rehabilitation*; D015921:Dental Implants; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011862:Radiography, Panoramic
chemical_list: D015921:Dental Implants
keywords: All-on-4; generalized aggressive periodontitis; immediate implant; immediate rehabilitation