title: The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury.
abstract: Burns are a global public health problem, accounting for an estimated 265,000 deaths annually. Inflammation is essential in supplying the growth factors, cytokines and chemokines needed to recruit T-cells and myeloid cells to the site of a burn injury for wound healing. However, major burns generate a marked pathophysiological inflammatory response through a widespread release of abundant pro-inflammatory mediators that predispose patients to a systemic inflammatory response syndrome, sepsis and multi-organ failure. Recently, there has been promising investigation into the role of γδ T-cells and Th-17 cells in the regulation and propagation of this inflammatory response. This study reviews the current literature on the post-burn immune response.
authors.affiliation: Severe Burns Unit, Royal North Shore Hospital, St Leonards NSW 2065, Australia. a.kim323@gmail.com.
authors.forename: Albert
authors.initials: A
authors.lastname: Kim
authors.affiliation: Severe Burns Unit, Royal North Shore Hospital, St Leonards NSW 2065, Australia. thomas.lang@sydney.edu.au.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lang
authors.affiliation: Sutton Arthritis Research Laboratory, Institute of Bone and Joint Research, University of Sydney, Sydney NSW 2006, Australia. meilang.xue@sydney.edu.au.
authors.forename: Meilang
authors.initials: M
authors.lastname: Xue
authors.affiliation: Severe Burns Unit, Royal North Shore Hospital, St Leonards NSW 2065, Australia. wijewardanaaruna@yahoo.com.
authors.forename: Aruna
authors.initials: A
authors.lastname: Wijewardana
authors.affiliation: Sutton Arthritis Research Laboratory, Institute of Bone and Joint Research, University of Sydney, Sydney NSW 2006, Australia. chris.jackson@sydney.edu.au.
authors.forename: Chris
authors.initials: C
authors.lastname: Jackson
authors.affiliation: Severe Burns Unit, Royal North Shore Hospital, St Leonards NSW 2065, Australia. johnvandervord@bigpond.com.
authors.forename: John
authors.initials: J
authors.lastname: Vandervord
mesh_terms: D000818:Animals; D002056:Burns / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology* / Q000378:metabolism; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines; D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: burns; cytokines; inflammation; systemic inflammatory response; γδ T-cells