title: Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins.
abstract: The collectins family encompasses several collagenous Ca2+-dependent defense lectins that are described as pathogen recognition molecules. They play an important role in both adaptive and innate immunity. Surfactant proteins A and D are two of these proteins which were initially discovered in association with surfactant in the pulmonary system. The structure, immune and inflammatory functions, and genetic variations have been well described in relation to their roles, function and pathophysiology in the pulmonary system. Subsequently, these proteins have been discovered in a wide range of other organs and organ systems. The role of these proteins outside the pulmonary system is currently an active area of research. This review intends to provide a current overview of the genetics, structure and extra-pulmonary functions of the surfactant collectin proteins.
authors.affiliation: Neonatal Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: frederico-vieira@ouhsc.edu.
authors.forename: Frederico
authors.initials: F
authors.lastname: Vieira
authors.affiliation: Neonatal Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: johannes-kung@ouhsc.edu.
authors.forename: Johannes W
authors.initials: JW
authors.lastname: Kung
authors.affiliation: Neonatal Perinatal Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; Oklahoma Center for Neurosciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. Electronic address: faizah-bhatti@ouhsc.edu.
authors.forename: Faizah
authors.initials: F
authors.lastname: Bhatti
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D037662:Pulmonary Surfactant-Associated Protein A / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D037663:Pulmonary Surfactant-Associated Protein D / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D013329:Structure-Activity Relationship
chemical_list: D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D
keywords: Collectins; Complement pathway; Extra-pulmonary; Surfactant protein A; Surfactant protein D