title: TNM Staging Matched-pair Comparison of Surgery After Neoadjuvant Chemoradiotherapy, Surgery Alone and Definitive Chemoradiotherapy for Thoracic Esophageal Squamous Cell Carcinoma.
abstract: Introduction:We used the TNM staging matched-pair approach to compare the efficacies of surgery after neoadjuvant chemoradiotherapy (NCT), surgery alone and definitive chemoradiotherapy (CCRT) in patients with localized advanced thoracic esophageal squamous cell carcinoma (ESCC).Methods:A total of 642 patients with ESCC from previous studies were studied. Patients whose treatment involved NCT + surgery and surgery alone were compared with patients receiving CCRT. Prospensity score matched-pair comparison based on pre-treatment TNM staging was developed to assess the efficacies of these treatment options.Results:Prospensity score matched-pair comparison to control for bias generated a cohort of 274 patients who were eligible for comparison. The 3-year OS rate was 70.0% in the NCT + surgery group, compared to 51.7% in the surgery group (p=0.000) and 61.9% in the CCRT group (p=0.082). With the TNM staging matched-pair approach, the CCRT group had more upper thoracic ESCC patients (43/92, 46.7%), while the surgery group had more lower thoracic ESCC patients (37/92, 40.2%). The 3-year OS rates were comparable between the surgery alone group and CCRT group (p=0.109).Conclusions:NCT plus surgery was superior in OS to surgery alone or CCRT. The 3-year OS rates were comparable between the surgery alone group and CCRT group with TNM staging matched-pair approach. Further investigation is warranted to confirm these findings.
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Radiation Oncology.
authors.forename: ShiLiang
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Radiation Oncology.
authors.forename: Bo
authors.initials: B
authors.lastname: Qiu
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Endoscopy.
authors.forename: GuangYu
authors.initials: G
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Medical Oncology.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Thoracic Surgery.
authors.forename: YuZhen
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Radiation Oncology.
authors.forename: ZhaoLin
authors.initials: Z
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Thoracic Surgery.
authors.forename: KongJia
authors.initials: K
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Radiation Oncology.
authors.forename: Mian
authors.initials: M
authors.lastname: Xi
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Clinical Statistics, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Radiation Oncology.
authors.forename: YongHong
authors.initials: Y
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Radiation Oncology.
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Thoracic Surgery.
authors.forename: JianHua
authors.initials: J
authors.lastname: Fu
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Radiation Oncology.
authors.forename: MengZhong
authors.initials: M
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Thoracic Surgery.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Oncology in South China;; Guangdong Esophageal Cancer Research Institute, Guangzhou, Guangdong, P.R. China;; Department of Radiation Oncology.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
keywords: Esophageal squamous cell carcinoma; definitive chemoradiotherapy; neoadjuvant chemoradiotherapy; surgery