title: Relationship between biological factors and catastrophizing and clinical outcomes for female patients with knee osteoarthritis.
abstract: OBJECTIVE
  To investigate the correlations between clinical outcomes and biopsychological variables in female patients with knee osteoarthritis (OA).
  
  
  METHODS
  Seventy-seven patients with symptomatic knee OA were enrolled in this study. We investigated the age, body mass index (BMI), pain catastrophizing scale (PCS) and radiographic severity of bilateral knees using a Kellgren-Lawrence (K-L) grading system of the subjects. Subsequently, a multiple linear regression was conducted to determine which variables best correlated with main outcomes of knee OA, which were pain severity, moving capacity by measuring timed-up-and-go test and Japanese Knee Osteoarthritis Measure (JKOM).
  
  
  RESULTS
  We found that the significant contributor to pain severity was PCS (β = 0.555) and BMI (β = 0.239), to moving capacity was K-L grade (β = 0.520) and to PCS (β = 0.313), and to a JKOM score was PCS (β = 0.485) and K-L grade (β = 0.421), respectively.
  
  
  CONCLUSIONS
  The results suggest that pain catastrophizing as well as biological factors were associated with clinical outcomes in female patients with knee OA, irrespective of radiographic severity.
authors.affiliation: Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Ikemoto
authors.affiliation: Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Miyagawa
authors.affiliation: Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Shiro
authors.affiliation: Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
authors.forename: Young-Chang Park
authors.initials: YP
authors.lastname: Arai
authors.affiliation: Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
authors.forename: Machiko
authors.initials: M
authors.lastname: Akao
authors.affiliation: Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Murotani
authors.affiliation: Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ushida
authors.affiliation: Tatsunori Ikemoto, Hirofumi Miyagawa, Young-Chang Park Arai, Takahiro Ushida, Institute of Physical Fitness, Sports Medicine and Rehabilitation, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Deie
keywords: Japanese Knee Osteoarthritis Measure; Knee pain; Osteoarthritis; Pain catastrophizing; Physical function