title: Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature.
abstract: Hereditary spherocytosis (HS) and Chronic myelocytic leukemia (CML) are both life threatening hemotologic diseases. They are rarely seen to occur simultaneously in one individual patient. Here we demonstrate a case of HS associated with CML in this study. The patient is a young female, diagnosed with HS in 2005, and was given partial embolization of the splenic artery. She got significant remission after the procedure. In 2008, she was found abnormal in blood routine test, after bone marrow routine, chromosome and fusion gene tests, she was diagnosed with CML (chronic phase). She did not receive regular treatment until 3 months prior, and is currently being treated with Dasatimib. She achieved hematological remission, but had no significant improvement in chromosome and fusion gene figures. Due to her severe condition of hemolysis, a splenectomy or an allogeneic hematopoietic stem cell transplantation is considered.
authors.affiliation: Department of Anesthe-siologic, Surgical and Emergency Sciences; Otolaryngology, Head and Neck Surgery Unit; Second University of Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Testa
authors.affiliation: University of Naples Federico II, Department of Otorhi-nolaryngology, Naples, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Motta
authors.affiliation: Department of Anesthesio-logic, Surgical and Emergency Sciences; Otolaryngology, Head and Neck Surgery Unit; Second University of Naples, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Marcuccio
authors.affiliation: Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Paccone
authors.affiliation: Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
authors.forename: Aldo
authors.initials: A
authors.lastname: Rocca
authors.affiliation: University of Naples Federico II, Pathology Unit, Naples, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Ilardi
authors.affiliation: Department of Sport Sciences and Wellness, University of Naples "Parthenope", Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Tafuri
authors.affiliation: Department of Neuroscience Reproductive and Dentistry Sciences, Otholaryngology Unit; University of Naples "Federico II", Naples, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mesolella
authors.affiliation: Department of Anesthesio-logic, Surgical and Emergency Sciences; Otolaryngology, Head and Neck Surgery Unit; Second University of Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Motta
keywords: CO2 Laser Cordectomy; Glottic sarcoma; Malignant Fibrous Hystiocytoma (MFH); Vocal Cord Cancer