title: [Effects of extract of Ginkgo biloba on magnetic resonance imaging and electroencephalography in patients with delayed encephalopathy after acute carbon monoxide poisoning].
abstract: Objective:To observe the effects of extract of Ginkgo biloba (Ginaton) on magnetic resonance imaging (MRI) and electroencephalography (EEG) in patients with delayed encephalopathy after acute carbon monoxide poisoning.Methods:The 84 patients with delayed encephalopathy after acute carbon monoxide poisoning treated in our hospital from Jan. 2011 to Apr. 2016 were randomly divied into therapy group and observation group. The therapy group received routine treatments of hyperbaric oxygen, cure cerebral edema and promote brain cell metabolism, and observation group was given intravenous injection (intravenous drip) Ginaton 70 mg (adding 0.9% sodium chloride injection 250 ml) , once a day, 2 weeks for one therapeutic course. The changes of MRI and EEG before and after treatment between therapy group and observation group were observed.Results:In the observation group, the white matter and globus pallidus lesions of 14 d after treatment were smaller than those in the treatment group, and the abnormal signal intensity was decreased. At 14 days after treatment the improvement of EEG in observation group were better than therapy group (P<0.05) .Conclusion:Early treatment of extract of Ginkgo biloba (Ginaton) in delayed encephalopathy after acute carbon monoxide poisoning can effectively improve lesion and signal on MRI and abnormal rate on EEG. It has a certain therapeutic effect in clinical.
authors.affiliation: Emergency Department of Harrison International Peace Hospital Affiliated to Hebei Medical University, Hengshui 053000, China.
authors.forename: Q M
authors.initials: QM
authors.lastname: Xiao
authors.forename: H N
authors.initials: HN
authors.lastname: Qi
authors.forename: W Z
authors.initials: WZ
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Gao
authors.forename: B Y
authors.initials: BY
authors.lastname: Zhu
authors.forename: Y J
authors.initials: YJ
authors.lastname: Liu
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: G Y
authors.initials: GY
authors.lastname: Ma
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.forename: F Z
authors.initials: FZ
authors.lastname: Meng
authors.forename: X F
authors.initials: XF
authors.lastname: Gao
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D001927:Brain Diseases / Q000209:etiology*; D002249:Carbon Monoxide Poisoning / Q000150:complications*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004569:Electroencephalography / Q000379:methods*; D020441:Ginkgo biloba; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*
chemical_list: D004365:Drugs, Chinese Herbal
keywords: Acute severe carbon monoxide poisoning; Delayed encephalopathy; Electroencephalography; Extract of Ginkgo biloba; Magnetic resonance imaging