title: Neuroimmunological response in neuro-Behçet's.
abstract: Behçet's disease is a chronic, multisystem, autoimmune vasculitis characterized by a triad of key signs. We report the case of a 16-year-old Caucasian girl, who complained of headache, dizziness and paresis of the left side of her body. After physical examination and ancillary tests, she was diagnosed with Behçet's disease with neurological manifestations (neuro-Behçet's disease). She had a good response to treatment. IgG, IgA, IgM and albumin were quantified in serum and cerebrospinal fluid by single radial immunodiffusion. Intrathecal synthesis was found for the 3 classes of immunoglobulins. This is the first case in which the Reibergram was used to evaluate the neuroimmunological response in a patient with Behçet's disease, suggesting the use of this diagnostic means for the active phase of the disease.
authors.affiliation: Instituto de Ciencias Básicas y Preclínicas Victoria de Girón, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba.
authors.forename: Alexis Alejandro
authors.initials: AA
authors.lastname: Garcia-Rivero
authors.affiliation: Instituto de Ciencias Básicas y Preclínicas Victoria de Girón, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba. Electronic address: jargote@infomed.sld.cu.
authors.forename: Javier
authors.initials: J
authors.lastname: Gonzalez-Argote
authors.affiliation: Laboratorio Central del Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba.
authors.forename: José Pedro
authors.initials: JP
authors.lastname: Martínez Larrarte
authors.affiliation: Laboratorio Central del Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba.
authors.forename: Ivonne Margarita
authors.initials: IM
authors.lastname: Iglesias González
authors.affiliation: Laboratorio Central del Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba.
authors.forename: Alberto Juan
authors.initials: AJ
authors.lastname: Dorta-Contreras
mesh_terms: D000293:Adolescent; D001327:Autoimmune Diseases / Q000175:diagnosis*; D001528:Behcet Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis*
keywords: Barrera sangre-líquido cefalorraquídeo; Behçet's disease; Blood-cerebrospinal fluid barrier; Enfermedad de Behçet; Immunoglobulins; Inmunoglobulinas; Intrathecal synthesis; Neuro-Behçet's disease; Neurobeçhet; Reibergram; Reibergrama; Síntesis intratecal