title: Coaxial interleaved stimulation of the thalamus and subthalamus for treatment of Holmes tremor.
abstract: Holmes tremor is often treated with multiple deep brain stimulation (DBS) electrodes. The authors describe a novel technique to suppress the tremors by effectively utilizing a single electrode. A 16-year-old boy presented with severe right arm tremor following a midbrain injury. A DBS electrode was implanted into the ventral oralis nucleus of the thalamus (VO) and the subthalamic region. While individual stimulation of each target was ineffective, an interleaved dual stimulation of both targets has been effective for 6 years. Coaxial interleaved stimulation of the VO and the subthalamic region is useful for treating Holmes tremor. The video can be found here: https://youtu.be/tSwGh3vy68c .
authors.affiliation: Department of Neurosurgery, Tazuke Kofukai Medical Research Institute and Kitano Hospital, Osaka; and.|Department of Neurosurgery, Fukui Red Cross Hospital, Fukui, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Toda
authors.affiliation: Department of Neurosurgery, Tazuke Kofukai Medical Research Institute and Kitano Hospital, Osaka; and.
authors.forename: Namiko
authors.initials: N
authors.lastname: Nishida
authors.affiliation: Department of Neurosurgery, Tazuke Kofukai Medical Research Institute and Kitano Hospital, Osaka; and.
authors.forename: Koichi
authors.initials: K
authors.lastname: Iwasaki
mesh_terms: D000293:Adolescent; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008297:Male; D020530:Subthalamus / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*; D014202:Tremor / Q000628:therapy
keywords: Holmes tremor; deep brain stimulation; subthalamus; thalamus