title: Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery.
abstract: This work aimed to explore the link between angiopoietin-like protein 8 (ANGPTL8) and weight loss after metabolic surgery. In the cross-sectional study (n = 100), circulating ANGPTL8 concentrations were significantly lower in morbidly obese than in lean subjects, and strikingly lower in morbidly obese patients with type 2 diabetes mellitus (T2DM). Conversely, ANGPTL8 expression in subcutaneous adipose tissue (SAT) was higher in morbidly obese patients, particularly in those with T2DM, whereas its expression in visceral adipose tissue was unchanged. The main predictors for circulating levels of ANGPTL8 were BMI and T2DM, whereas ANGPTL8 expression in SAT was determined by the presence of T2DM. The prospective cohort studies before and 1 year after bariatric surgery in morbidly obese patients with (n = 45) and without (n = 30) T2DM, revealed a significant increase of circulating ANGPTL8 levels 1 year after the bariatric surgery. Intriguingly, this increment, which was predicted by basal ANGPTL8 concentrations, appeared as a determinant of T2DM remission. In conclusion, circulating ANGPTL8 levels have an inverse relationship with SAT expression. Low basal levels of ANGPTL8 rebound after bariatric surgery. The increment in ANGPTL8 concentrations at 1 month of follow-up after weight loss emerged as a significant predictor of the T2DM remission at 1 year of follow-up.
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Ejarque
authors.affiliation: Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.
authors.forename: Marianne
authors.initials: M
authors.lastname: Borlaug
authors.affiliation: CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain; Obesity Unit and Endocrinology and Nutrition Departments, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Vilarrasa
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain.
authors.forename: Bruno
authors.initials: B
authors.lastname: Martinez-Perez
authors.affiliation: CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain; Department of Endocrinology and Nutrition, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Llauradó
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Megía
authors.affiliation: Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.
authors.forename: Thomas
authors.initials: T
authors.lastname: Helland
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gutierrez
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Carolina
authors.initials: C
authors.lastname: Serena
authors.affiliation: Department of Medicine, Haugesund Hospital, Haugesund, Norway.
authors.forename: Oddry
authors.initials: O
authors.lastname: Folkestad
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Catalina
authors.initials: C
authors.lastname: Nuñez-Roa
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Kelly
authors.initials: K
authors.lastname: Roche
authors.affiliation: Obesity Unit and Endocrinology and Nutrition Departments, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Casajoana
authors.affiliation: Hospital St. Pau i Sta Tecla, Tarragona, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Fradera
authors.affiliation: Department of Endocrinology and Nutrition, Hospital de Sabadell, Corporació Sanitària i Universitària Parc Taulí (Universitat Autònoma de Barcelona), Sabadell, Spain.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: González-Clemente
authors.affiliation: Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: López
authors.affiliation: Department of Medicine, Haugesund Hospital, Haugesund, Norway.
authors.forename: Arne C
authors.initials: AC
authors.lastname: Mohn
authors.affiliation: Department of Medicine, Haugesund Hospital, Haugesund, Norway.
authors.forename: Bjørn G
authors.initials: BG
authors.lastname: Nedrebø
authors.affiliation: Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Ruben
authors.initials: R
authors.lastname: Nogueiras
authors.affiliation: Hormone Laboratory, Haukeland University Hospital, Bergen, Norway; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Mellgren
authors.affiliation: Hormone Laboratory, Haukeland University Hospital, Bergen, Norway; KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway. Electronic address: Johan.Ferno@uib.no.
authors.forename: Johan
authors.initials: J
authors.lastname: Fernø
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: sonia.fernandezveledo@gmail.com.
authors.forename: Sonia
authors.initials: S
authors.lastname: Fernández-Veledo
authors.affiliation: Hospital Universitari de Tarragona Joan XXIII, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Tarragona, Spain; CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jvortega2002@gmail.com.
authors.forename: Joan
authors.initials: J
authors.lastname: Vendrell
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D050110:Bariatric Surgery; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology; D009767:Obesity, Morbid / Q000097:blood / Q000378:metabolism / Q000601:surgery; D036361:Peptide Hormones / Q000097:blood / Q000235:genetics; D011446:Prospective Studies; D050151:Subcutaneous Fat / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; C576683:ANGPTL8 protein, human; D015415:Biomarkers; D036361:Peptide Hormones