title: A bidirectional synthesis of spiroacetals via Rh(ii)-catalysed C-H insertion.
abstract: Acyclic methylene acetals bearing two diazoester subunits have been converted to [5,5]-spiroacetals via bidirectional C-H insertion under Rh(ii) catalysis. Using a chiral Rh(ii) catalyst, the major diastereomer can be produced in high enantiomeric excess (89%).
authors.affiliation: Griffith Institute for Drug Discovery (GRIDD), Griffith University, Don Young Rd, Nathan, Queensland 4111, Australia. m.coster@griffith.edu.au.
authors.forename: Romain J
authors.initials: RJ
authors.lastname: Lepage
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: White
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Coster