title: Serum levels of nesfatin-1 are increased in gestational diabetes mellitus.
abstract: OBJECTIVE
  To analyze the concentrations of nesfatin-1 in maternal and cord serum, to evaluate the expression of nesfatin-1 in subcutaneous adipose tissue (SAT) from pregnant women with gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT).
  
  
  METHODS
  We studied a total of 50 GDM and 50 NGT subjects. The clinical features, serum nesfatin-1, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profiles were measured at the third trimester of pregnancy. The expression of nesfatin-1 in the SAT was determined by western blot.
  
  
  RESULTS
  Compared with the NGT group, the GDM group showed greater levels of serum nesfatin-1, adipocyte fatty acid binding protein (AFABP), and leptin; a greater level of cord blood nesfatin-1; and a higher level of expression in SAT (p < 0.05 or p < 0.01). Fasting insulin (FI) (b = 0.317, p= 0.022) and body mass index (BMI) before delivery (b = 0.367, p=0.008) were independently associated with serum nesfatin-1. Nesfatin-1 was the independent risk factor for GDM.
  
  
  CONCLUSIONS
  The GDM group had higher levels of maternal serum and cord blood nesfatin-1, and greater nesfatin-1 expression in SAT. Nesfatin-1 is closely related to obesity and IR in pregnancy.
authors.affiliation: a Department of Endocrinology , Guangzhou , PR China.|b Department of Obstetrics and Gynecology , The Third Affiliated Hospital of Guangzhou Medical University , Guangzhou , PR China , and.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a Department of Endocrinology , Guangzhou , PR China.
authors.forename: Jia-Hui
authors.initials: JH
authors.lastname: Lu
authors.affiliation: a Department of Endocrinology , Guangzhou , PR China.
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Zheng
authors.affiliation: a Department of Endocrinology , Guangzhou , PR China.
authors.forename: Jia-He
authors.initials: JH
authors.lastname: Yan
authors.affiliation: a Department of Endocrinology , Guangzhou , PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.affiliation: a Department of Endocrinology , Guangzhou , PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: b Department of Obstetrics and Gynecology , The Third Affiliated Hospital of Guangzhou Medical University , Guangzhou , PR China , and.
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Wu
authors.affiliation: c Key Laboratory for Major Obstetric Diseases of Guangdong Higher Education Institutes , Guangzhou , PR China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000097:blood* / Q000378:metabolism; D002681:China; D004268:DNA-Binding Proteins / Q000097:blood* / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D050556:Fatty Acid-Binding Proteins / Q000097:blood / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000097:blood* / Q000378:metabolism; D000080866:Nucleobindins; D011247:Pregnancy; D050507:Subcutaneous Fat, Abdominal / Q000378:metabolism; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; D007328:Insulin; D020738:Leptin; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
keywords: Adipocytokine; gestational diabetes mellitus; insulin resistance; nesfatin-1