title: Possible effect of landscape design on IgE recognition profiles of two generations revealed with micro-arrayed allergens.
abstract: The aim of this study was to investigate possible effects of landscape design on the IgE sensitization profile toward inhalant allergens in patients with respiratory allergy from Uzbekistan where green areas have been changed during the last two decades by a State program. Sera from two different generations of Uzbek (n=58) and, for control purposes, from two generations of Austrian (n=58) patients were analyzed for IgE reactivity to 112 different micro-arrayed allergen molecules by ImmunoCAP ISAC technology. Changes in molecular IgE sensitization profiles to pollen allergens in the young vs the middle-aged Uzbek population were associated with replanting, whereas those in the Vienna populations reflected natural changes in plant growth. Our data indicate that anthropologic as well as natural changes in the biome may have effects on IgE sensitization profiles already from one to another generation.
authors.affiliation: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
authors.forename: V
authors.initials: V
authors.lastname: Garib
authors.affiliation: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Wollmann
authors.affiliation: Specialized Scientific-Practical Center for Therapy and Medical Rehabilitation (RSSPMC T&R), Tashkent, Uzbekistan.
authors.forename: G
authors.initials: G
authors.lastname: Djambekova
authors.affiliation: Vienna Challenge Chamber, Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Lemell
authors.affiliation: Department of Oto-Rhino-Laryngology, Medical University of Vienna, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Kmenta
authors.affiliation: Department of Oto-Rhino-Laryngology, Medical University of Vienna, Vienna, Austria.
authors.forename: U
authors.initials: U
authors.lastname: Berger
authors.affiliation: Vienna Challenge Chamber, Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Zieglmayer
authors.affiliation: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
authors.forename: R
authors.identifier: http://orcid.org/0000-0001-5944-3365
authors.initials: R
authors.lastname: Valenta
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D000918:Antibody Specificity / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D018604:Epitope Mapping / Q000379:methods; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000276:immunology; D055815:Young Adult
chemical_list: D000485:Allergens; D007073:Immunoglobulin E
keywords: IgE profiles; allergen; component-resolved diagnosis; landscape design; molecular allergology