title: Overexpression of Yes-associated protein and its association with clinicopathological features of hepatocellular carcinoma: A meta-analysis.
abstract: Yes-associated protein (YAP) overexpression is reported to be associated with risk of hepatocellular carcinoma (HCC) but current studies have not explored the relationship between YAP expression with HCC clinicopathological features.
  
  
  
  To assess these associations, a meta-analysis was performed which included four eligible studies including 391 HCC cases and 334 controls. There were eight eligible studies to investigate the association between YAP expression in HCC and clinicopathological features of liver cancer patients. Literature was obtained from PubMed, Embase, Wangfang and China National Knowledge Infrastructure.
  
  
  
  Analysis indicated that YAP expression in HCC was greater than in adjacent non-tumour tissue (odds ratio [OR], 15.80, 95% confidence interval [CI], 10.53-23.70, P<.00001; heterogeneity=.30). YAP overexpression in HCC was significantly associated with vascular invasion (OR, 2.21, 95% CI, 11.64-2.97, P<.00001, heterogeneity=.10), less cellular differentiation (OR, 2.38, 95% CI, 1.61-3.51, P<.00001, heterogeneity=.333), tumours larger than 5 cm (OR, 2.52, 95% CI, 1.75-3.62, P<.00001; heterogeneity=.17) and TNM tumour stage I + II (OR, 0.44, 95% CI, 0.28-0.75, P=.00003, heterogeneity=.12).
  
  
  
  Overexpression of YAP contributes to HCC formation, and its overexpression is associated with vascular invasion, low cellular differentiation tumours larger than 5 cm and TNM tumour stage III + IV.
authors.affiliation: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.|Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Affiliated Guilin Medical University, Guilin, Guangxi, China.
authors.forename: Chengjie
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.|Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Affiliated Guilin Medical University, Guilin, Guangxi, China.
authors.forename: Zhigao
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Affiliated Guilin Medical University, Guilin, Guangxi, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Lei
authors.affiliation: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, China.
authors.forename: Hongping
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, China.
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.|Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Affiliated Guilin Medical University, Guilin, Guangxi, China.
authors.forename: Songqing
authors.identifier: 0000-0002-8966-2195
authors.initials: S
authors.lastname: He
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging; D010750:Phosphoproteins / Q000235:genetics*; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human
keywords: Yes-associated protein; clinicopathological feature; hepatocellular carcinoma; meta-analysis