title: Monoclonal Antibodies for the Treatment of Nasal Polyps.
abstract: Biologics are novel therapeutic medications developed for the targeted therapy for a variety of inflammatory conditions. The biologics currently investigated for the treatment of chronic rhinosinusitis (CRS) with nasal polyps modulate specific inflammatory pathways involved in the pathogenesis of disease. Investigations have focused on the most severe form of the disease, namely, CRS with nasal polyps. It is hoped that specific targeted therapies using these biologics can significantly modulate the immune system, offering both disease control and symptomatic relief. This review summarizes those therapies that have been used to treat nasal polyps.
authors.affiliation: Department of Otolaryngology, Head & Neck Surgery, University of Pittsburgh Medical Center, 1400 Locust Street, Suite 2100, Building D, Pittsburgh, PA 15219, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Willson
authors.affiliation: Section of Otolaryngology, Head & Neck Surgery, The University of Chicago Medical Center, MC 1035, 5841 South Maryland Avenue, Chicago, IL 60615, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Naclerio
authors.affiliation: Department of Otolaryngology, Head & Neck Surgery, University of Pittsburgh Medical Center, 1400 Locust Street, Suite 2100, Building D, Pittsburgh, PA 15219, USA. Electronic address: lees6@upmc.edu.
authors.forename: Stella E
authors.initials: SE
authors.lastname: Lee
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers; D002908:Chronic Disease; D006801:Humans; D056747:Immunomodulation / Q000187:drug effects; D018793:Interleukin-13 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D015848:Interleukin-5 / Q000037:antagonists & inhibitors / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009298:Nasal Polyps / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D012220:Rhinitis / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D063265:Sialic Acid Binding Immunoglobulin-like Lectins / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D018793:Interleukin-13; D015848:Interleukin-5; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; C026408:anti-IgE antibodies; D015847:Interleukin-4
keywords: Allergic rhinitis; Asthma; Biologics; Chronic rhinosinusitis; Nasal polyps