title: Toll Like Receptors Signaling Pathways as a Target for Therapeutic Interventions.
abstract: This review summarizes the key role of Toll-Like Receptor (TLRs) molecules for igniting the immune system. Activated by a broad spectrum of pathogens, cytokines or other specific molecules, TLRs trigger innate immune responses. Published data demonstrate that the targeting and suppression of TLRs and TLR-related proteins with particular inhibitors may provide pivotal treatments for patients with cancer, asthma, sepsis, Crohn's disease and thrombosis. Many drugs that target cytokines act in the late phases of the activated pathways, after the final peptides, proteins or glycoproteins are formed in the cell environment. TLR activity occurs in the early activation of cellular pathways; consequently inhibiting them might be most beneficial in the treatment of human diseases.
authors.affiliation: Vascular Biology Center, Medical College of Georgia, USA.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jezierska
authors.affiliation: Johns Hopkins University, Blumberg School of Public Health, Baltimore, Maryland, USA.
authors.forename: Irina A
authors.initials: IA
authors.lastname: Kolosova
authors.affiliation: Vascular Biology Center, Medical College of Georgia, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Medical College of Georgia, USA.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Verin
keywords: TLR; signaling pathways; therapy