title: Predictors of Impaired HDL Function in HIV-1 Infected Compared to Uninfected Individuals.
abstract: High-density lipoprotein (HDL) function rather than absolute level may be a more accurate indicator for cardiovascular disease (CVD). Novel methods can measure HDL function using patient samples. The objective of this study is to identify factors that may contribute to HDL dysfunction in chronic treated HIV-1 infection.
  
  
  
  Retrospective study of HDL function measured in 2 ways in HIV-1-infected men with low overall CVD risk and healthy men with no known CVD risk matched by race to the HIV-1-infected participants.
  
  
  
  We examined patient-level factors associated with 2 different measures of HDL dysfunction: reduced antioxidant function (oxidized HDL, HDLox) and reduced HDL-apoA-I exchange (HAE), a measure of HDL remodeling, in the HIV infected and control men. Multivariable-adjusted linear regression analyses were used adjusting for false discovery rate, age, race, body mass index (BMI), CD4 count, viremia, CVD risk, smoking, lipids, apoA-I, and albumin.
  
  
  
  In multivariate analysis among HIV-1-infected men (n = 166) (median age 45 years, CD4 T-cell count 505 cells/mm, 30.1% were viremic), higher BMI, lower apoA-I, and lower albumin were among the most notable correlates of higher HDLox and lower HAE (P < 0.05). In HIV-1 uninfected participants, lower albumin and higher BMI were associated with lower HAE and higher HDLox, respectively (P ≤ 0.05). HDLox was inversely related to HAE in HIV-1-infected individuals (P < 0.001).
  
  
  
  Increased HDLox correlates with reduced HAE in chronic HIV-1 infection. Higher BMI, lower apoA-I, and albumin were identified as factors associated with HDL dysfunction in chronic HIV-1 infection using 2 independent methods.
authors.affiliation: *Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA; †Children's Hospital Oakland Research Institute, Oakland, CA; and ‡Department of Medicine Statistics Core, UCLA, Los Angeles, CA.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Kelesidis
authors.forename: Michael N
authors.initials: MN
authors.lastname: Oda
authors.forename: Mark S
authors.initials: MS
authors.lastname: Borja
authors.forename: Yumin
authors.initials: Y
authors.lastname: Yee
authors.forename: Kit F
authors.initials: KF
authors.lastname: Ng
authors.forename: Diana
authors.initials: D
authors.lastname: Huynh
authors.forename: David
authors.initials: D
authors.lastname: Elashoff
authors.forename: Judith S
authors.initials: JS
authors.lastname: Currier
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000821:virology; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000097:blood* / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology* / Q000821:virology; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000276:immunology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D019562:Viral Load
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL