title: CRP relevance in clinical assessment of chronic spontaneous urticaria Tunisian patients.
abstract: BACKGROUND
  Chronic spontaneous urticaria (CSU) is a common dermatological condition defined by the sudden occurrence of daily wheals and pruritus for at least six weeks. Multifactorial origin is suggested such as oxidative stress. This latter may play a double role as a trigger and remnant agent.
  
  
  OBJECTIVE
  The first aim of this study is to investigate antioxidant status, inflammatory proteins, hematologic counts and clinical assessment in CSU patients. The second aim is to evaluate the effect of a first-line treatment: desloratadine 5 mg/d on these different parameters.
  
  
  METHODS
  This study enrolled 30 CSU patients and same number of controls. We assessed the urticaria activity score (UAS), total antioxidant status (TAS), glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), albumin, alpha1, alpha2, beta1 beta2, gamma globulins, c-reactive protein (CRP) and hematologic numeration.
  
  
  RESULTS
  At baseline alpha1, alpha2, beta1, beta2, gamma globulins, CRP, SOD activity, leukocytes and basophils were significantly higher in patients versus controls (p < 0.05). TAS, GST, CAT, GPx and albumin were significantly low in patients versus controls (p < 0.05). After treatment, TAS, GST and GPx were significantly increased in patients versus patients before treatment (p < 0.001). SOD, alpha1, alpha2, beta1, beta2, gamma globulins, CRP, albumin, leukocytes and basophils were significantly decreased after treatment versus before treatment (p < 0.05). A significant correlation between CRP and UAS (r = 0.3; p = 0.011) was noted. UAS assessment revealed the efficacy of 30 d-antihistaminic treatment.
  
  
  CONCLUSIONS
  Desloratadine exerted anti-inflammatory and antioxidant effects on CSU patients revealed by CRP. Patients' remission was synergistic to CRP attenuation emphasizing CRP relevance for CSU clinical assessment.
authors.affiliation: a Laboratory of Bioressources, Integrative Biology and Valorization, Higher Institute of Biotechnology of Monastir , Monastir , Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Maouia
authors.affiliation: b Department of Dermatology , CHU Fattouma Bourguiba , Monastir , Tunisia , and.
authors.forename: M
authors.initials: M
authors.lastname: Youssef
authors.affiliation: c Faculty of Pharmacy Biochemistry and Molecular Biology Laboratory, University of Monastir , Monastir , Tunisia.
authors.forename: N
authors.initials: N
authors.lastname: Leban
authors.affiliation: c Faculty of Pharmacy Biochemistry and Molecular Biology Laboratory, University of Monastir , Monastir , Tunisia.
authors.forename: J
authors.initials: J
authors.lastname: Ben Chibani
authors.affiliation: a Laboratory of Bioressources, Integrative Biology and Valorization, Higher Institute of Biotechnology of Monastir , Monastir , Tunisia.
authors.forename: A N
authors.identifier: http://orcid.org/0000-0001-8178-2566
authors.initials: AN
authors.lastname: Helal
authors.affiliation: c Faculty of Pharmacy Biochemistry and Molecular Biology Laboratory, University of Monastir , Monastir , Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Kassab
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000032:analysis*; D002374:Catalase / Q000097:blood; D002908:Chronic Disease; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D039563:Histamine H1 Antagonists, Non-Sedating / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D017336:Loratadine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood; D014416:Tunisia; D014581:Urticaria / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D039563:Histamine H1 Antagonists, Non-Sedating; D017336:Loratadine; D002097:C-Reactive Protein; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; C121345:desloratadine
keywords: Chronic spontaneous urticaria; desloratadine; inflammation; oxidative stress