title: Bioactive Constituents Obtained from the Seeds of Lepidium apetalum Willd.
abstract: Three new compounds, apetalumosides C₁ (1), D (2), and 1-thio--d-glucopyranosyl(1→1)-1-thio-α-d-glucopyranoside (3), together with twenty-two known ones (4-25) were obtained from the seeds ofLepidium apetalumWilld. Among the known isolates,5-8,10-13,16-20, and25were obtained from the genus for the first time;4,14,15, and21-24were isolated from the species for the first time. Meanwhile, the NMR data of 16 was first reported here. Their structures were determined by means of chemical and spectroscopic methods. On the other hand, their inhibitory effects on sodium oleate-induced triglyceride (TG) overloading in HepG2 cells were evaluated. As a result, two new compounds (1and2), together with known isolates 7-11, 13, 14, 16-18, 20, 21, and 25 possessed significant inhibitory effects in the cells.
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. 15122587883@163.com.
authors.forename: Sijian
authors.initials: S
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. qululuhan88@163.com.
authors.forename: Pingping
authors.initials: P
authors.lastname: Shi
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. Ruanjy19930919@163.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Qu
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. yuhaiyang19830116@hotmail.com.
authors.forename: Jingya
authors.initials: J
authors.lastname: Ruan
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. shipingpingtcm@163.com.
authors.forename: Shengcai
authors.initials: S
authors.lastname: Yang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. 15122473723@163.com.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Yu
authors.affiliation: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. zhwwxzh@263.net.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. wangtao@tjutcm.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D056945:Hep G2 Cells / Q000187:drug effects; D006801:Humans; D029686:Lepidium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D019301:Oleic Acid / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D010936:Plant Extracts; D014280:Triglycerides; D019301:Oleic Acid; C013173:osteum
keywords: HepG2 cells; Lepidium apetalum; flavonoid glycosides; phenolic glycosides; triglyceride accumulation inhibitory effects