title: Generating Recombinant Pseudorabies Virus for Use as a Vaccine Platform.
abstract: Pseudorabies virus (PRV) is a promising vaccine vector due to its distinctive features including many nonessential replication regions and a broad host range. Foreign genes of other viruses have been successfully inserted into and expressed in PRV and these recombinant viruses are very likely to induce humoral and/or cellular responses in immunized animals. This chapter offers an overview of methods for generating recombinant pseudorabies virus for use as a vaccine vector.
authors.affiliation: National Research Center for Veterinary Medicine, Luoyang, China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Tan
authors.affiliation: National Research Center for Veterinary Medicine, Road Cuiwei, High-Tech District, Luoyang, 471003, Henan, PR China.
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Li
authors.affiliation: National Research Center for Veterinary Medicine, Road Cuiwei, High-Tech District, Luoyang, 471003, Henan, PR China. tiankg@263.net.|College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China. tiankg@263.net.
authors.forename: Kegong
authors.initials: K
authors.lastname: Tian
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D005822:Genetic Vectors / Q000235:genetics; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000276:immunology*; D006801:Humans; D011995:Recombination, Genetic; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology*; D014709:Vero Cells
chemical_list: D014614:Vaccines, Synthetic
keywords: Bacterial artificial chromosome; Pseudorabies; Recombination; Vaccine platform