title: Targeting personalized medicine in a non-Hodgkin lymphoma patient with 18F-FDG and 18F-choline PET/CT.
abstract: Early diagnosis and staging of non-Hodgkin lymphoma (NHL) is essential for therapeutic strategy decision. Positron emission tomography/computed tomography (PET/CT) with fluordeoxyglucose (FDG), a glucose analogue, labeled with fluor-18 (18F-FDG) has been used to evaluate staging, therapy response and prognosis in NHL patients. However, in some cases, 18F-FDG has shown false-positive uptake due to inflammatory reaction after chemo and/or radiation therapy. In this case report, we present a NHL patient evaluated with 18F-FDG and 18F-choline PET/CT scan imaging pre- and post-therapy. 18F-FDG and 18F-choline PET/CT were performed for the purpose of tumor staging and have shown intense uptake in infiltrative tissue as well as in the lymph node, but with some mismatching in the tumor. Post-treatment 18F-FDG and 18F-choline PET/ CT scans revealed no signs of radiotracer uptake, suggesting complete remission of the tumor. 18F-choline may be a complimentary tool for staging and assessment of therapeutic response in non-Hodgkin lymphoma, while non-18F-FDG tracer can be used for targeted therapy and patient management.
authors.affiliation: Molecular Medicine Center of Technology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors.forename: Thalles H
authors.initials: TH
authors.lastname: Ribeiro
authors.affiliation: Molecular Medicine Center of Technology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
authors.forename: Raul
authors.initials: R
authors.lastname: S
authors.affiliation: Oncology Section, University Hospital, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
authors.forename: Ana Carolina G
authors.initials: AC
authors.lastname: Castro
authors.affiliation: Pathology Department, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Paulino
authors.affiliation: Molecular Medicine Center of Technology, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.|Anatomy and Imaging Department, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Mamede
mesh_terms: D002794:Choline; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D012878:Skin Neoplasms / Q000000981:diagnostic imaging*; D013249:Sternum
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D002794:Choline