title: Acute Disseminated Talaromyces marneffei in An Immunocompetent Patient.
abstract: Talaromyces marneffei (also called Penicilliosis Marneffei or T. marneffei) is a rare fungal disease that is prevalent mainly in Southeast Asia and commonly seen in immunocompromised hosts. It was rarely observed in immunocompetent hosts. We report a case of acute disseminated T. marneffei in an immunocompetent patient in the non-prevalent region. This patient had never visited the endemic area. The patient experienced a persistent fever. Brain CT and magnetic resonance imaging (MRI) showed a mass in the right frontal with osteolytic damage. Excessive white blood cell (WBC) count and C-reactive protein content were observed. Antibiotics including meropenem and linezolid could not play an effect, and another two hard masses appeared in his right neck and front chest wall. The aspirates from the right frontal mass and bone marrow were cultured. The final diagnose of this infection was disseminated T. marneffei. After voriconazole treatment, all symptoms improved gradually. We present this case and aim to promote more clinicians and microbiologists in the non-endemic region to recognize this rare disease.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 of Jiefang Road, Shangcheng District, Hangzhou, 310009, China.
authors.forename: Pingli
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 of Jiefang Road, Shangcheng District, Hangzhou, 310009, China.
authors.forename: Youfei
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 of Jiefang Road, Shangcheng District, Hangzhou, 310009, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 of Jiefang Road, Shangcheng District, Hangzhou, 310009, China.
authors.forename: Liren
authors.initials: L
authors.lastname: Ding
authors.affiliation: Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 of Jiefang Road, Shangcheng District, Hangzhou, 310009, China.
authors.forename: Zuqun
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Microbiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
authors.forename: Zhijiang
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 of Jiefang Road, Shangcheng District, Hangzhou, 310009, China. kaiw@zju.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001208:Asia; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D016469:Fungemia / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D007958:Leukocyte Count; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000473:pathology; D032901:Talaromyces / Q000302:isolation & purification*; D035441:Thoracic Wall / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D002097:C-Reactive Protein; D065819:Voriconazole
keywords: Immunocompetent; Immunocompromised; Penicilliosis marneffei; Talaromyces marneffei