title: Effect of blood biochemical factors on nontraumatic necrosis of the femoral head : Logistic regression analysis.
abstract: OBJECTIVE
  This case-control study aimed to identify the risk factors of nontraumatic necrosis of the femoral head (NONFH).
  
  
  METHODS
  In all, 242 patients with NONFH treated at the hip disease research center of our hospital between March 2012 and October 2015 were included. After excluding 19 patients with tumor or tuberculosis, 223 patients were enrolled. Controls comprised 223 healthy persons selected from our hospital database. Single-factor variance analysis and t test were performed to select the index of statistical significance. The 95% confidence interval (95% CI) and normal range of the selected indicators were compared, and abnormal related indexes were selected from the femoral head necrosis group. The selected indicators were based on the increase or decrease to locate the risk indicators and render their corresponding assignment. Logistic regression analysis of the risk factors was performed after the assignment.
  
  
  RESULTS
  The necrotic group of patients with decreased carbon dioxide combining power (CO2CP), increased total cholesterol, increased low-density lipoprotein, and decreased high-density lipoprotein levels had statistically significant partial regression coefficient values and the odds ratios were 73.5 (95% CI 24.59-219.74), 7.15 (3.51-14.85), 633.07 (121.7-3304.78), and 20.11 (9.36-43.8), respectively, indicating that these are strong risk factors for NONFH.
  
  
  CONCLUSIONS
  Abnormal lipid metabolism is a strong risk factor of NONFH. Lipid examination can be used as a screening tool for NONFH in high-risk populations, for alcoholism, and many hormone applications. The decreased CO2CP was associated with NONFH, and bone microcirculation was considered to possibly lead various conditions such as ischemia and hypoxia-related bone metabolic acidosis. However, further study is needed.
authors.affiliation: Medical Center for the Hip, Luoyang Orthopedic-Traumatological Hospital, No. 82 South Qiming Road, 471002, Luoyang, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Medical Center for the Hip, Luoyang Orthopedic-Traumatological Hospital, No. 82 South Qiming Road, 471002, Luoyang, China.
authors.forename: Ruibo
authors.initials: R
authors.lastname: Sun
authors.affiliation: Medical Center for the Hip, Luoyang Orthopedic-Traumatological Hospital, No. 82 South Qiming Road, 471002, Luoyang, China.
authors.forename: Leilei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: The First Affiliated Hospital of Guangzhou University of Chinese Medicine, 510006, Guangzhou, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Feng
authors.affiliation: Medical Center for the Hip, Luoyang Orthopedic-Traumatological Hospital, No. 82 South Qiming Road, 471002, Luoyang, China. liuyouwenzhenggu@sina.com.
authors.forename: Youwen
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000097:blood*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005271:Femur Head Necrosis / Q000097:blood*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002245:Carbon Dioxide; D002784:Cholesterol
keywords: Carbon dioxide combining power; High-density lipoproteins; Lipid metabolism disorders; Low-density lipoproteins; Total cholesterol