title: Stereoselective Sequence toward Biologically Active Fused Alkylidenecyclobutanes.
abstract: Combining an efficient preparation of cyclobutenylmetal species, high-yielding cross-coupling reactions, and highly diastereoselective [4 + 2]-cycloaddition led to opening a new route toward the synthesis of fused alkylidenecyclobutanes containing up to five consecutive stereocenters. New complex architectures, analogues to protoilludane skeletons, were obtained in a very efficient manner and with a minimum number of steps starting from commercial sources and were tested for their cytotoxicity against leukemia cell lines HL60.
authors.affiliation: Department of Chemistry and Pharmacy, Ludwig-Maximilians-University , Butenandtstraße 5-13, 81377 Munich, Germany.
authors.forename: Andreas N
authors.initials: AN
authors.lastname: Baumann
authors.affiliation: Department of Chemistry and Pharmacy, Ludwig-Maximilians-University , Butenandtstraße 5-13, 81377 Munich, Germany.
authors.forename: Michael
authors.identifier: 0000-0002-2314-3990
authors.initials: M
authors.lastname: Eisold
authors.affiliation: Department of Chemistry and Pharmacy, Ludwig-Maximilians-University , Butenandtstraße 5-13, 81377 Munich, Germany.
authors.forename: Dorian
authors.identifier: 0000-0002-6358-1485
authors.initials: D
authors.lastname: Didier