title: Anatomy of Mammalian Replication Domains.
abstract: Genetic information is faithfully copied by DNA replication through many rounds of cell division. In mammals, DNA is replicated in Mb-sized chromosomal units called "replication domains." While genome-wide maps in multiple cell types and disease states have uncovered both dynamic and static properties of replication domains, we are still in the process of understanding the mechanisms that give rise to these properties. A better understanding of the molecular basis of replication domain regulation will bring new insights into chromosome structure and function.
authors.affiliation: Department of Biochemistry and Proteomics, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan. stake@doc.medic.mie-u.ac.jp.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Takebayashi
authors.affiliation: Department of Biochemistry and Proteomics, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan. ogata@doc.medic.mie-u.ac.jp.
authors.forename: Masato
authors.initials: M
authors.lastname: Ogata
authors.affiliation: Laboratory of Molecular and Cellular Biology, Department of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Mie 514-8507, Japan. katsu@bio.mie-u.ac.jp.
authors.forename: Katsuzumi
authors.initials: K
authors.lastname: Okumura
keywords: DNA replication; mammalian chromosome; replication domain; replication foci; replication origin