title: Overexpression of ezrin and galectin-3 as predictors of poor prognosis of cervical cancer.
abstract: The aim of this study was to explore the correlation of ezrin and galectin-3 expressions with prognosis in cervical cancer. The immunohistochemical method was applied to detect ezrin and galectin-3 expressions in normal cervix tissues (n=30), cervicitis tissues (n=28), cervical intraepithelial neoplasia (CIN) tissues (classified as I-III, n=89), and cervical carcinoma tissues (n=84). Follow-up was conducted for 5 to 78 months to analyze the correlation of protein expressions with prognosis. Ezrin and galectin-3 expressions in cervical cancer were significantly higher than in normal cervix, cervicitis and CIN (all P<0.05), and expressions in CIN were significantly higher than in normal cervix and cervicitis (both P<0.05). The expressions of ezrin and galectin-3 were both related with histological grade, deep myometrial invasion and lymph node metastasis (all P<0.05). Spearman analysis showed that ezrin expression was positively correlated with galectin-3 expression in cervical cancer (r=0.355, P<0.05). The survival rate of patients with high expressions of ezrin and galectin-3 was significantly lower than those with low expressions of proteins (both P<0.05). The expressions of ezrin and galectin-3, histological grade, depth of stromal invasion, and lymph node metastasis are risk factors affecting the survival rate of patients with cervical cancer. The expressions of ezrin and galectin-3 were correlated with the development of cervical cancer, and overexpressions of those proteins were indicative of poor prognosis in patients with cervical cancer.
authors.affiliation: Department of Obstetrics, The Second People's Hospital of Huaian, Huaian, Jiangsu Province, China.
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Obstetrics, The Second People's Hospital of Huaian, Huaian, Jiangsu Province, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Feng
authors.affiliation: Department of Obstetrics, The Second People's Hospital of Huaian, Huaian, Jiangsu Province, China.
authors.forename: S Q
authors.initials: SQ
authors.lastname: Fang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D018196:Carcinoma, Adenosquamous / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D005260:Female; D037502:Galectin 3 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012016:Reference Values; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D002578:Uterine Cervical Dysplasia / Q000378:metabolism*; D000099149:Ezrin
chemical_list: D003598:Cytoskeletal Proteins; D037502:Galectin 3; D000099149:Ezrin