title: Efficacy and Adverse Events Associated With Use of OnabotulinumtoxinA for Treatment of Neurogenic Detrusor Overactivity: A Meta-Analysis.
abstract: OBJECTIVE
  OnabotulinumtoxinA is used widely for the treatment of neurogenic detrusor overactivity. We conducted a systematic review and meta-analysis to assess its efficacy and safety for neurogenic detrusor overactivity treatment.
  
  
  METHODS
  A systematic literature review was performed to identify all published randomized double-blind, placebo-controlled trials of onabotulinumtoxinA for neurogenic detrusor overactivity treatment. MEDLINE, Embase, and the CENTRAL were employed. Reference lists of retrieved studies were reviewed carefully.
  
  
  RESULTS
  Six publications involving 871 patients, which compared onabotulinumtoxinA with a placebo were analyzed. Efficacy of onabotulinumtoxinA treatment was shown as a reduction of the mean number of urinary incontinence episodes per day (mean difference, -1.41; 95% confidence interval [CI], -1.70 to -1.12; P<0.00001), maximum cystometric capacity (135.48; 95% CI, 118.22-152.75; P<0.00001), and maximum detrusor pressure (-32.98; 95% CI, -37.33 to -28.62; P<0.00001). Assessment of adverse events revealed that complications due to onabotulinumtoxinA injection were localized primarily to the urinary tract.
  
  
  CONCLUSIONS
  This meta-analysis suggests that onabotulinumtoxinA is an effective treatment for neurogenic detrusor overactivity with localized advent events.
authors.affiliation: Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
authors.forename: Hejia
authors.identifier: 0000-0001-8834-2926
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
authors.forename: Yuanshan
authors.identifier: 0000-0002-6688-449X
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
authors.forename: Jitao
authors.identifier: 0000-0002-0378-0925
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Pathology, Affiliated Hospital of Taishan Medical University, Taian, China.
authors.forename: Peng
authors.identifier: 0000-0001-7489-1852
authors.initials: P
authors.lastname: Peng
authors.affiliation: Department of Urology, Qingdao Chengyang People's Hospital, Qingdao, China.
authors.forename: Xujie
authors.identifier: 0000-0002-4187-1203
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
authors.forename: Zhenli
authors.identifier: 0000-0002-2241-4242
authors.initials: Z
authors.lastname: Gao
keywords: Meta-Analysis; Neurogenic Detrusor Overactivity; OnabotulinumtoxinA; Randomized Controlled Trial