title: Echocardiographic evaluation of diastolic functions in patients with polycystic ovary syndrome: A comperative study of diastolic functions in sub-phenotypes of polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder among reproductive-aged women. It is known to be associated with cardiovascular diseases. The aim of this study was to determine and compare the echocardiographic data of patients according to the phenotypes of PCOS.
  
  
  METHODS
  This study included 113 patients with PCOS and 52 controls. Patients were classified into four potential PCOS phenotypes. Laboratory analyses and echocardiographic measurements were performed. Left ventricular mass was calculated by using Devereux formula and was indexed to body surface area.
  
  
  RESULTS
  Phenotype-1 PCOS patients had significantly higher homeostasis model assessment - insu-lin resistance (HOMA-IR) (p = 0.023), free testosterone (p < 0.001), LDL cholesterol levels (p < 0.001) and free androgen index (p < 0.001) compared with the control group. There were significant differences between groups regarding the septal thickness, posterior wall thickness, Left ventricular ejection frac-tion, E/A ratio and left ventricular mass index (for all, p < 0.05). PCOS patients with phenotype 1 and 2 had significantly higher left ventricular mass index than the control group (p < 0.001). In univariate and multivariate analyses, PCOS phenotype, modified Ferriman-Gallwey Score and estradiol were found as variables, which independently could affect the left ventricular mass index.
  
  
  CONCLUSIONS
  This study showed that women in their twenties who specifically fulfilled criteria for PCOS phenotype-1 according to the Rotterdam criteria, had higher left ventricular mass index and decreased E/A ratio, which might be suggestive of early stage diastolic dysfunction. (Cariol J 2017; 24, 4: 364-373).
authors.affiliation: Gulhane Research and Training Hospital, Ankara. dr_erkanyildirim@yahoo.com.tr.
authors.forename: Erkan
authors.initials: E
authors.lastname: Yildirim
authors.forename: Onur
authors.initials: O
authors.lastname: Karabulut
authors.forename: Uygar Cagdas
authors.initials: UC
authors.lastname: Yuksel
authors.forename: Murat
authors.initials: M
authors.lastname: Celik
authors.forename: Baris
authors.initials: B
authors.lastname: Bugan
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Gokoglan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ulubay
authors.forename: Mutlu
authors.initials: M
authors.lastname: Gungor
authors.forename: Mustafa
authors.initials: M
authors.lastname: Koklu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D003971:Diastole; D015150:Echocardiography, Doppler; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016014:Linear Models; D015999:Multivariate Analysis; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D012307:Risk Factors; D013739:Testosterone / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D016277:Ventricular Function, Left; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008078:Cholesterol, LDL; D007328:Insulin; D013739:Testosterone; D004958:Estradiol
keywords: diastolic dysfunction; echocardiography; left ventricular mass; polycystic ovary syndrome