title: Bioactive Molecule-loaded Drug Delivery Systems to Optimize Bone Tissue Repair.
abstract: Bioactive molecules such as peptides and proteins can optimize the repair of bone tissue; however, the results are often unpredictable when administered alone, owing to their short biological half-life and instability. Thus, the development of bioactive molecule-loaded drug delivery systems (DDS) to repair bone tissue has been the subject of intense research. DDS can optimize the repair of bone tissue owing to their physicochemical properties, which improve cellular interactions and enable the incorporation and prolonged release of bioactive molecules. These characteristics are fundamental to favor bone tissue homeostasis, since the biological activity of these factors depends on how accessible they are to the cell. Considering the importance of these DDS, this review aims to present relevant information on DDS when loaded with osteogenic growth peptide and bone morphogenetic protein. These are bioactive molecules that are capable of modulating the differentiation and proliferation of mesenchymal cells in bone tissue cells. Moreover, we will present different approaches using these peptide and protein-loaded DDS, such as synthetic membranes and scaffolds for bone regeneration, synthetic grafts, bone cements, liposomes, and micelles, which aim at improving the therapeutic effectiveness, and we will compare their advantages with commercial systems.
authors.affiliation: Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-Jaú, Km 1, Araraquara, 14800- 903 SP. Brazil.
authors.forename: Joao Augusto
authors.initials: JA
authors.lastname: Oshiro
authors.affiliation: Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-Jaú, Km 1, Araraquara, 14800- 903 SP,. Brazil.
authors.forename: Mariana Rillo
authors.initials: MR
authors.lastname: Sato
authors.affiliation: Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), Humaitá, 1680, Araraquara, 14801-385 SP. Brazil.
authors.forename: Cassio Rocha
authors.initials: CR
authors.lastname: Scardueli
authors.affiliation: Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), Humaitá, 1680, Araraquara, 14801-385 SP,. Brazil.
authors.forename: Guilherme Jose Pimentel
authors.initials: GJP
authors.lastname: Lopes de Oliveira
authors.affiliation: Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-Jaú, Km 1, Araraquara, 14800- 903 SP. Brazil.
authors.forename: Marina Paiva
authors.initials: MP
authors.lastname: Abucafy
authors.affiliation: Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-Jaú, Km 1, Araraquara, 14800-903 SP. Brazil.
authors.forename: Marlus
authors.initials: M
authors.lastname: Chorilli
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000378:metabolism; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods; D001842:Bone and Bones / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D016503:Drug Delivery Systems / Q000379:methods*; D006657:Histones / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000494:pharmacology*; D008081:Liposomes / Q000008:administration & dosage / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008823:Micelles; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
chemical_list: C525718:BMP2 protein, human; D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D006657:Histones; D036341:Intercellular Signaling Peptides and Proteins; D008081:Liposomes; D008823:Micelles; C074533:osteogenic growth peptide
keywords: Bioactive molecules; bone morphogenetic protein; drug delivery systems; osteogenic growth peptide; tissue repair