title: Antidiabetic, hypolipidemic and hepatoprotective effects ofArctium lapparoot's hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice.
abstract: OBJECTIVE
  Arctium lappa(burdock),(A. lappa)root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties ofA. lapparoot extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice.
  
  
  METHODS
  In this investigation, 70 adult male NMRI mice (30-35g) randomly divided into 7 groups (n=10) as follow: 1-control, 2-type 2 diabetic mice, 3-diabetic mice that received glibenclamide (0.25 mg/kg) as an anti-diabetic drug, 4, 5, 6 and 7- diabetic and normal animals that were pre-treated with 200 and 300 mg/kgA. lapparoot extract, respectively, for 28 days. Diabetes has been induced by intraperitoneal injection of NA and STZ. Finally, the blood sample was taken and insulin, glucose, SGOT, SGPT, alkaline phosphatase, leptin and lipid levels was evaluated.
  
  
  RESULTS
  Induction of diabetes decreased the level of insulin, leptin and high density lipoprotein (HDL) and increased the level of other lipids, glucose, and hepatic enzymes significantly (p<0.05). Administration of both doses of the extract significantly decreased the level of triglyceride, very low density lipoprotein, glucose and alkaline phosphatase in diabetic mice (p<0.05). Insulin levels increased in animals treated with 200 mg/kg (p<0.05) and HDL and leptin levels increased in animals treated with 300 mg/kg of the extract (p<0.01).
  
  
  CONCLUSIONS
  The results showed thatA. lapparoot extract, at specific doses, has an anti-diabetic effect through its hypolipidemic and insulinotropic properties. Hence, this plant extract may be beneficial in the treatment of diabetes.
authors.affiliation: Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Ahangarpour
authors.affiliation: Department of Physiology, Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Physiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Heidari
authors.affiliation: Department of Physiology, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Oroojan
authors.affiliation: Department of Nutrition, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Farhang
authors.initials: F
authors.lastname: Mirzavandi
authors.affiliation: Department of Nutrition, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Khalil
authors.initials: K
authors.lastname: Nasr Esfehani
authors.affiliation: Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Dehghan Mohammadi
keywords: Arctium Lappa; Hepatic enzyme; Insulin; Lipid profile; Type 2 diabetes