title: Correlation of Caveolin-1 Expression with Prognosis in Patients with Gastric Cancer after Gastrectomy.
abstract: BACKGROUND
  Upregulation of caveolin-1 (Cav-1) expression is correlated with histopathological grade and poor prognosis in several human cancers. However, in gastric cancer, its clinical utility as a useful prognostic molecular marker remains unclear.
  
  
  METHODS
  The prognostic importance of Cav-1 expression was retrospectively analyzed by immunohistochemistry in 148 patients with gastric cancer who had undergone radical gastrectomy.
  
  
  RESULTS
  Cav-1 expression was positive in 23 (15.5%) patients and negative in 125 (84.5%) patients. Tumor location, tumor grade, lymph node involvement, pT stage, pTNM stage, and the presence of recurrence were found to be significantly associated with Cav-1 expression. The median disease-free survival (DFS) of patients with negative Cav-1 expression was significantly better than that of patients with positive Cav-1 expression (not reached vs. 10.2 months, p < 0.001). Moreover, patients with positive Cav-1 expression had a worse median overall survival (OS) compared to patients with negative Cav-1 expression (14.2 vs. 40.3 months, p = 0.004). In the multivariate analysis, Cav-1 expression (positive vs. negative) was an independent prognostic factor for DFS (p < 0.001, hazard ratio (HR) 2.58) and OS (p = 0.031, HR 1.87), as was lymph node metastasis.
  
  
  CONCLUSIONS
  Our results suggest that positive Cav-1 expression is associated with progression and poor prognosis in gastric cancer patients after radical gastrectomy. Targeting Cav-1 would be a potential option for future gastric cancer treatment.
authors.forename: Mesut
authors.initials: M
authors.lastname: Seker
authors.forename: Dincer
authors.initials: D
authors.lastname: Aydin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Bilici
authors.forename: Dilek
authors.initials: D
authors.lastname: Yavuzer
authors.forename: Melin G
authors.initials: MG
authors.lastname: Ozgun
authors.forename: Melike
authors.initials: M
authors.lastname: Ozcelik
authors.forename: Ozhan
authors.initials: O
authors.lastname: Aydin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aliustaoglu
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D051242:Caveolin 1 / Q000378:metabolism*; D005260:Female; D005743:Gastrectomy / Q000401:mortality* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D051242:Caveolin 1