title: [Enterovirus infection during pregnancy: Underestimated cause of fetal and neonatal complications?]
abstract: Enteroviruses are responsible for about one billion infections every year in the world. The clinical expression is in the vast majority asymptomatic cases (90%). Its consequences during pregnancy are rarely described. From the Medline database, we selected and analyzed 34 articles ranging from 1965 to 2015, to analyse the current knowledge of enterovirus infection consequences during pregnancy. We found that enterovirus infections may be the cause of fetal loss. The enterovirus infections during the 2nd and 3rd trimester may also lead to in utero fetal anomalies and death, but also to severe neonatal infections. PCR enterovirus detection should be performed during pregnancy and the peripartum in case of unexplained fever, specific fetal anomalies or unexplained fetal demise.
authors.affiliation: Department of obstetrics and gynecology, hôpital Foch, 92120 Suresnes, France.
authors.forename: J
authors.initials: J
authors.lastname: Méreaux
authors.affiliation: EA2493, UFR des sciences de la santé Simone-Veil, université Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France; Risk in pregnancy university department, 75006 Paris, France; Service de gynécologie et obstétrique, hôpital Louis-Mourier, Assistance publique-Hôpitaux de Paris, 178, rue des Renouillers, 92700 Colombes, France; Université Paris-Diderot, 75013 Paris, France; Inserm CESP, 94276 Le Kremlin-Bicêtre cedex, France. Electronic address: olivier.picone@aphp.fr.
authors.forename: O
authors.initials: O
authors.lastname: Picone
authors.affiliation: Inserm U1193, virologie, WHO Rubella NRL, National Reference Laboratory for Maternofetal Rubella Infections, AP-HP, hôpital Paul-Brousse, groupe hospitalier universitaire Paris-Sud, université Paris-Sud, 94804 Villejuif, France.
authors.forename: C
authors.initials: C
authors.lastname: Vauloup-Fellous
authors.affiliation: Risk in pregnancy university department, 75006 Paris, France; Service de gynécologie et obstétrique, hôpital Louis-Mourier, Assistance publique-Hôpitaux de Paris, 178, rue des Renouillers, 92700 Colombes, France; Université Paris-Diderot, 75013 Paris, France; Inserm CESP, 94276 Le Kremlin-Bicêtre cedex, France.
authors.forename: Z
authors.initials: Z
authors.lastname: Khediri
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine and Centre, maladies rares : hernie de coupole diaphragmatique, hôpital Antoine-Béclère, AP-HP, université Paris Sud, 157, rue de la Porte-de-Trivaux, 92140 Clamart, France.
authors.forename: A
authors.initials: A
authors.lastname: Benachi
authors.affiliation: Risk in pregnancy university department, 75006 Paris, France; Service de gynécologie et obstétrique, hôpital Louis-Mourier, Assistance publique-Hôpitaux de Paris, 178, rue des Renouillers, 92700 Colombes, France; Université Paris-Diderot, 75013 Paris, France; Inserm CESP, 94276 Le Kremlin-Bicêtre cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Mandelbrot
authors.affiliation: Department of obstetrics and gynecology, hôpital Foch, 92120 Suresnes, France; EA2493, UFR des sciences de la santé Simone-Veil, université Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Ayoubi
mesh_terms: D004770:Enterovirus / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005315:Fetal Diseases / Q000175:diagnosis / Q000517:prevention & control / Q000821:virology*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000517:prevention & control / Q000821:virology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011295:Prenatal Care / Q000379:methods
keywords: Congenital infection; Enterovirus; Infection congénitale; Intra-uterine fetal demise; Mort fœtale in utero; Perte fœtale; Pregnancy loss; RT-PCR