title: Salivary Prostaglandin E2: Role in Tick-Induced Allergy to Red Meat.
abstract: Tick-induced allergy to red meat is associated with anti-α-Gal IgE antibody levels. We propose that tick salivary prostaglandin E2 triggers antibody class switching in mature B cells, increasing the levels of anti-α-Gal IgE antibodies. Immune tolerance to α-Gal in blood type B individuals might reduce the risk to this allergy.
authors.affiliation: Institute of Parasitology, Biology Center of the Academy of Sciences of the Czech Republic, 37005 České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, 37005 České Budějovice, Czech Republic.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Cabezas-Cruz
authors.affiliation: SaBio. Instituto de Investigación de Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mateos-Hernández
authors.affiliation: Faculty of Science, University of South Bohemia, 37005 České Budějovice, Czech Republic.
authors.forename: Jindrǐch
authors.initials: J
authors.lastname: Chmelař
authors.affiliation: SaBio. Instituto de Investigación de Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Villar
authors.affiliation: SaBio. Instituto de Investigación de Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain; Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. Electronic address: jose_delafuente@yahoo.com.
authors.forename: José
authors.initials: J
authors.lastname: de la Fuente
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000276:immunology*; D005512:Food Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D000069466:Red Meat; D012463:Saliva / Q000276:immunology; D064927:Tick Bites / Q000150:complications* / Q000276:immunology; D013987:Ticks / Q000276:immunology*; D000519:alpha-Galactosidase / Q000276:immunology
chemical_list: D007073:Immunoglobulin E; D000519:alpha-Galactosidase; D015232:Dinoprostone
keywords: PGE(2); blood groups; food allergy; immunology; tick; α-Gal