title: Direct Csp2-H enolization: an allenoate alkylation cascade toward the assembly of multi-substituted furans.
abstract: A new disconnection toward tri- and tetrasubstituted furans has been conceptualized and demonstrated. A mild, base-mediated reaction of an allenoate pronucleophile with α-halo ketones/dicarbonyl compounds results in a Csp2-alkylation/enolization/O-vinylation sequence to ultimately afford substituted furan derivatives. The reaction offers a broad scope, provides a facile access to alkyl and aryl substituted furans, and demonstrates the application of the allene functionality as a two-carbon component in the construction of furans.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, U.P., India.
authors.forename: Debanjan
authors.initials: D
authors.lastname: Bakshi
authors.forename: Anand
authors.initials: A
authors.lastname: Singh