title: The relationship between the helicobacter pylori seropositivity with systemic and local oxidative status and hyperemesis gravidarum: a pilot study.
abstract: OBJECTIVE
  The aim of study was to determine the helicobacter pylori (HP) seropositivity and oxidative parameters in serum and saliva of pregnant women with poor oral hygiene and hyperemesis gravidarum (HG).
  
  
  METHODS
  A case-control study was conducted involving 50 pregnant women in their first trimester of pregnancy. Twenty-five subjects had a diagnosis of HG, and remaining 25 were healthy pregnant women who served as control subjects were included. The groups were adjusted for age, parity and gestational week. All patients were subjected to the measurement of total oxidant status (TOS) and total antioxidant status in serum and saliva. Also HP seropositivity was investigated.
  
  
  RESULTS
  Serum TAS and TOS values were similar, although oxidative burden in saliva of women with HG were significantly higher than controls. HP seropositivity was found to be 24% in women with HG and 4% of controls.
  
  
  CONCLUSIONS
  Our results suggest that significantly increased oxidative burden and slightly decreased antioxidative capacity of saliva may be involved in the pathogenesis of HG and this condition may be the result of HP infection which was found to be significantly more common in women with poor oral hygiene and HG.
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Sanko University , Gaziantep , Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Göymen
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Sanko University , Gaziantep , Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Özdurak
authors.affiliation: a Department of Obstetrics and Gynecology , Faculty of Medicine, Sanko University , Gaziantep , Turkey.
authors.forename: Şükran Esra
authors.initials: ŞE
authors.lastname: Özkaplan
authors.affiliation: b Department of Obstetrics and Gynecology , Faculty of Medicine, Kirikkale University , Kirikkale , Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Şimsek
authors.affiliation: c Department of Obstetrics and Gynecology , Aksehir Hospital , Konya , Turkey.
authors.forename: Fazıl
authors.initials: F
authors.lastname: Avcı
authors.affiliation: d Department of Obstetrics and Gynecology , Ankara Mevki Military Hospital , Ankara , Turkey.
authors.forename: Yaşam Kemal
authors.identifier: http://orcid.org/0000-0002-1699-8667
authors.initials: YK
authors.lastname: Akpak
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000097:blood; D000975:Antioxidants / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000378:metabolism / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood / Q000378:metabolism / Q000382:microbiology*; D016877:Oxidants / Q000097:blood / Q000302:isolation & purification; D010084:Oxidation-Reduction; D010865:Pilot Projects; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology; D011261:Pregnancy Trimester, First; D012463:Saliva / Q000737:chemistry* / Q000382:microbiology*; D016036:Seroepidemiologic Studies
chemical_list: D000907:Antibodies, Bacterial; D000975:Antioxidants; D016877:Oxidants
keywords: Helicobacter pylori; hyperemesis gravidarum; oxidative status; pregnancy; seropositivity