title: HPV epigenetic mechanisms related to Oropharyngeal and Cervix cancers.
abstract: Human Papilloma Virus infection is very frequent in humans and is mainly transmitted sexually. The majority of infections are transient and asymptomatic, however, if the infection persists, it can occur with a variety of injuries to skin and mucous membranes, depending on the type of HPV involved. Some types of HPV are classified as high oncogenic risk as associated with the onset of cancer. The tumors most commonly associated with HPV are cervical and oropharyngeal cancer, epigenetic mechanisms related to HPV infection include methylation changes to host and viral DNA and chromatin modification in host species. This review is focused about epigenethic mechanism, such as MiRNAs expression, related to cervix and oral cancer. Specifically it discuss about molecular markers associated to a more aggressive phenotype. In this way we will analyze genes involved in meiotic sinaptonemal complex, transcriptional factors, of orthokeratins, sinaptogirin, they are all expressed in cancer in a way not more dependent on cell differentiation but HPV-dependent.
authors.affiliation: a Department of Biochemistry , Biophysics and General Pathology, University of Campania "Luigi Vanvitelli" , Italy.|b IRCCS Institute of Women's Health Malzoni Clinic , Avellino , Italy.|c Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University , Philadelphia , PA , USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Di Domenico
authors.affiliation: d Department of Experimental Medicine , Section of Hygiene, Occupational Medicine and Forensic Medicine, University of Campania "Luigi Vanvitelli" , Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Giovane
authors.affiliation: e Laboratory BVBGR, LR11ES31, ISBST, Higher Institute of Biotechnology of Sidi Thabet, University of Manouba , Tunis , Tunisia.|f Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University Tunis El Manar , Tunis.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Kouidhi
authors.affiliation: a Department of Biochemistry , Biophysics and General Pathology, University of Campania "Luigi Vanvitelli" , Italy.
authors.forename: Rosamaria
authors.initials: R
authors.lastname: Iorio
authors.affiliation: g Hepatobiliary and Liver Transplantation Unit, Azienda Ospedaliera , Padova , Italy.|h Department of Surgical , Gastrointestinal and Oncological Sciences (DiSCOG), University of Padova , Padova ( PD ), Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Romano
authors.affiliation: h Department of Surgical , Gastrointestinal and Oncological Sciences (DiSCOG), University of Padova , Padova ( PD ), Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Francesco
authors.affiliation: a Department of Biochemistry , Biophysics and General Pathology, University of Campania "Luigi Vanvitelli" , Italy.
authors.forename: Antonia
authors.initials: A
authors.lastname: Feola
authors.affiliation: a Department of Biochemistry , Biophysics and General Pathology, University of Campania "Luigi Vanvitelli" , Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Siciliano
authors.affiliation: i Department of Maxillofacial Surgery , University of Naples "Federico II" , Naples , Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Califano
authors.affiliation: c Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University , Philadelphia , PA , USA.|j Department of Medicine , Surgery and Neuroscience, University of Siena , Siena , Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
mesh_terms: D002471:Cell Transformation, Neoplastic; D004279:DNA, Viral; D004198:Disease Susceptibility; D044127:Epigenesis, Genetic; D005260:Female; D005786:Gene Expression Regulation; D005814:Genes, Viral; D054884:Host-Pathogen Interactions; D006801:Humans; D035683:MicroRNAs; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*
chemical_list: D004279:DNA, Viral; D035683:MicroRNAs
keywords: Cancer; HPV; MiRNAs; epigenetic mechanisms; oropharyngeal and cervical cancer