title: Safety of Treatments for ADHD in Adults: Pairwise and Network Meta-Analyses.
abstract: The aim of the study was to analyze evidence comparing the profile of drugs used to treat ADHD in adult patients.
  
  
  
  Systematic searches were conducted in electronic databases. Randomized, double-blind, parallel controlled trials that evaluated the safety of drugs in ADHD were included. The statistical analyses were conducted by pairwise meta-analyses and mixed treatment comparison (MTC).
  
  
  
  Ten ( n = 3006) trials were included in the analyses. We observed statistical differences for the following outcomes: decreased appetite between atomoxetine and placebo (odds ratio [OR] = 0.15, 95% credibility interval [CrI] = [0.05, 0.38]) and extended-release mixed amphetamine salts and placebo (OR = 0.06, 95% CrI = [0.00, 0.51]); insomnia between atomoxetine and placebo (OR = 0.48, 95% CrI = [0.27, 0.88]) and extended-release mixed amphetamine salts and placebo (OR = 0.23, 95% CrI = [0.06, 0.76]); sleepiness between atomoxetine and methylphenidate OROS (OR = 0.24, 95% CrI = [0.06, 0.97]); and decreased libido between atomoxetine and placebo (OR = 0.28, 95% CrI = [0.08, 0.90]).
  
  
  
  It was possible to generate evidence about the safety profile of different ADHD drugs.
authors.affiliation: 1 Universidade Estadual do Oeste do Paraná, Cascavel, Brazil.
authors.forename: Danielly
authors.initials: D
authors.lastname: Chierrito de Oliveira
authors.affiliation: 1 Universidade Estadual do Oeste do Paraná, Cascavel, Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Guerrero de Sousa
authors.affiliation: 1 Universidade Estadual do Oeste do Paraná, Cascavel, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Borges Dos Reis
authors.affiliation: 2 Universidade Federal do Paraná, Curitiba, Brazil.
authors.forename: Fernanda Stumpf
authors.initials: FS
authors.lastname: Tonin
authors.affiliation: 2 Universidade Federal do Paraná, Curitiba, Brazil.
authors.forename: Laiza
authors.initials: L
authors.lastname: Maria Steimbach
authors.affiliation: 1 Universidade Estadual do Oeste do Paraná, Cascavel, Brazil.
authors.forename: Suzane
authors.initials: S
authors.lastname: Virtuoso
authors.affiliation: 3 Universidade de Lisboa, Lisboa, Portugal.
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernandez-Llimos
authors.affiliation: 2 Universidade Federal do Paraná, Curitiba, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pontarolo
authors.affiliation: 1 Universidade Estadual do Oeste do Paraná, Cascavel, Brazil.
authors.forename: Andréia
authors.initials: A
authors.lastname: Cristina Conegero Sanches
mesh_terms: D000328:Adult; D006801:Humans; D018759:Adrenergic Uptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D000661:Amphetamine / Q000009:adverse effects / Q000627:therapeutic use; D000069445:Atomoxetine Hydrochloride / Q000009:adverse effects / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use; D016208:Databases, Factual; D008774:Methylphenidate / Q000009:adverse effects / Q000627:therapeutic use; D016017:Odds Ratio; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced; D016896:Treatment Outcome; D014851:Wakefulness / Q000187:drug effects
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000661:Amphetamine; D000069445:Atomoxetine Hydrochloride; D000697:Central Nervous System Stimulants; D008774:Methylphenidate
keywords: ADHD; adult ADHD treatment; decision making; review