title: The role of basic leucine zipper transcription factor E4BP4 in the immune system and immune-mediated diseases.
abstract: Basic leucine zipper transcription factor E4BP4 (also known as NFIL3) has been implicated in the molecular and cellular mechanisms of functions and activities in mammals. The interactions between E4BP4 and major regulators of cellular processes have triggered significant interest in the roles of E4BP4 in the pathogenesis of certain chronic diseases. Indeed, novel discoveries have been emerging to illustrate the involvement of E4BP4 in multiple disorders. It is recognized that E4BP4 is extensively involved in some immune-mediated diseases, but the mechanisms of E4BP4 involvement in these complex diseases remain poorly defined. Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies.
authors.affiliation: Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, No. 139, Renmin Road, Changsha 410011, China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH43210, USA. Electronic address: jian.zhang@osumc.edu.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, No. 139, Renmin Road, Changsha 410011, China. Electronic address: qianlu5860@csu.edu.cn.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Lu
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000276:immunology*; D006801:Humans; D007107:Immune System; D007154:Immune System Diseases / Q000276:immunology
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; C497440:NFIL3 protein, human
keywords: Cellular processes; E4BP4; Immune-mediated-diseases; Mouse models