title: Phase contrast synchrotron radiation computed tomography of muscle spindles in the mouse soleus muscle.
abstract: Muscle spindles are skeletal muscle sensory organs involved in the sensation of position and movement of the body. We have explored the capability of phase contrast computed tomography to visualise muscle spindles in murine skeletal muscle. In particular, we have validated the visualisation of nerve fibres through phase contrast computed tomography using light microscopy on stained histological sections. We further present the first three-dimensional visualisation of muscle spindles in mouse soleus skeletal muscle in conjunction with the neurovascular bundle associated with it.
authors.affiliation: Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.|Helmholtz-Zentrum für Material- und Küstenforschung, Geesthacht, Germany.
authors.forename: B
authors.identifier: http://orcid.org/0000-0002-7562-9423
authors.initials: B
authors.lastname: Zeller-Plumhoff
authors.affiliation: Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.
authors.forename: T
authors.identifier: http://orcid.org/0000-0001-8710-1063
authors.initials: T
authors.lastname: Roose
authors.affiliation: Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.|μ-VIS X-ray Imaging Centre, University of Southampton, Southampton, UK.
authors.forename: O L
authors.identifier: http://orcid.org/0000-0003-4367-4147
authors.initials: OL
authors.lastname: Katsamenis
authors.affiliation: Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.|μ-VIS X-ray Imaging Centre, University of Southampton, Southampton, UK.
authors.forename: M N
authors.identifier: http://orcid.org/0000-0002-3956-2866
authors.initials: MN
authors.lastname: Mavrogordato
authors.affiliation: Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: C
authors.identifier: http://orcid.org/0000-0003-4377-0112
authors.initials: C
authors.lastname: Torrens
authors.affiliation: Faculty of Engineering and the Environment, University of Southampton, Southampton, UK.
authors.forename: P
authors.identifier: http://orcid.org/0000-0001-7499-3576
authors.initials: P
authors.lastname: Schneider
authors.affiliation: Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: G F
authors.identifier: http://orcid.org/0000-0002-6226-8964
authors.initials: GF
authors.lastname: Clough
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D009470:Muscle Spindles / Q000000981:diagnostic imaging*; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging*; D017356:Synchrotrons; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: computed tomography; muscle spindles; neurovascular bundle; phase contrast; synchrotron radiation