title: Epigenetic regulation in monocyte/macrophage: A key player during atherosclerosis.
abstract: Atherosclerosis is a chronic inflammatory disease. Recently, a growing body of evidence emphasizes that the monocyte and macrophage differentiation and activation are key processes in the development of atherosclerosis. However, the regulatory mechanism that manipulates the function of monocyte and macrophage is still unclear. Recent years, epigenetic mechanisms have received a wide attention and bring us a new field of vision. More and more evidence shows that epigenetics weighs heavily in atherosclerosis by regulating the function and differentiation states of monocyte and macrophage. In this review, we illuminate the epigenetic regulation mechanisms in monocyte and macrophage and their contributions to inflammatory processes of atherosclerosis to provide new thoughts and find novel targets or biomarkers for atherosclerosis.
authors.affiliation: Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China.|Department of Pharmaceutics, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Su-Jie
authors.identifier: http://orcid.org/0000-0002-0104-0544
authors.initials: SJ
authors.lastname: Jia
authors.affiliation: Department of Pharmaceutics, The Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Gao
authors.affiliation: Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism* / Q000473:pathology; D050197:Atherosclerosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006801:Humans; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D009000:Monocytes / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D058226:Plaque, Atherosclerotic; D012307:Risk Factors; D015398:Signal Transduction
keywords: Atherosclerosis; Epigenetics; Inflammation; Macrophage; Monocyte