title: Postprandial decrease in LDL-cholesterol in men with metabolic syndrome.
abstract: BACKGROUND
  In some epidemiological studies, blood lipids are determined at non-fasting state, which may impact cardiovascular risk estimation. The aim of this study was to evaluate postprandial LDL-C changes in men with newly diagnosed metabolic syndrome (MetSy).
  
  
  METHODS
  36 male patients were examined: 12 men with and 24 men without MetSy. The fat tolerance test was performed before and after a three-month hypolipidemic treatment. Serum lipids were measured using routine methods, lipid peroxides (LPO) colorimetrically, apolipoproteins A-I, B, and hsCRP immunoturbidimetrically.
  
  
  RESULTS
  The postprandial increase in triglycerides was associated with a decrease in LDL-C and a small decrease in apo B. In men with MetSy, the mean change in LDL-C (-19.5 ± 2.3 mg/dl) was greater than in healthy men (-5.7 ± 3.8 mg/dl). All lipid changes (ΔTG, ΔLDL-C and ΔLPO) were linearly dependent on the postprandial non-LDL-cholesterol. After three months of hypolipidemic treatment, in all men with MetSy, the apoB/apoA-I ratio remained the same as before the therapy.
  
  
  CONCLUSIONS
  In men diagnosed with MetSy, postprandial decreases in LDL-cholesterol may cause underestimation of cardiovascular risk. After three months of hypolipidemic treatment, there was only a partial reduction in this risk, as the apoB/apoA-I ratio remained the same.
authors.affiliation: Wroclaw Medical University, Department of Internal and Occupational Diseases, and Hypertension, Borowska 213, 50-556 Wrocław, Poland, tel.: 71-7364005, fax: 71-7364009.
authors.forename: Anna
authors.initials: A
authors.lastname: Skoczyńska
authors.affiliation: Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Turczyn
authors.affiliation: Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Wojakowska
authors.affiliation: Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland.
authors.forename: Bogusława
authors.initials: B
authors.lastname: Kreczyńska
authors.affiliation: Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Skoczyńska
authors.affiliation: Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland.
authors.forename: Kamila
authors.initials: K
authors.lastname: Wojtas
keywords: Postprandial LDL-cholesterol; apoB/apoA ratio; metabolic syndrome