title: Antimicrobial resistance in the Bacteroides fragilis group in faecal microbiota from healthy Danish children.
abstract: The Bacteroides fragilis group constitute a significant portion of the human gut microbiota and comprise a major proportion of anaerobic bacteria isolated in human infections. We established a baseline of antimicrobial susceptibility rates in the B. fragilis group in the intestinal tract of relatively antibiotic-naive healthy Danish children. From 174 faecal samples collected from children attending day care, 359 non-duplicate isolates were screened for antimicrobial susceptibility. Of these, 0.0%, 1.9%, 5.0% and 21.2% of isolates were intermediate-susceptible or resistant to metronidazole, meropenem, piperacillin/tazobactam and clindamycin, respectively. Eighteen additional studies reporting susceptibility rates in the B. fragilis group bacteria were identified by conducting a literature search. Heterogeneity among results from studies of B. fragilis group antimicrobial susceptibility rates in faecal microbiota exists.
authors.affiliation: Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark. Electronic address: Thomas.sydenham@dadlnet.dk.
authors.forename: Thomas Vognbjerg
authors.initials: TV
authors.lastname: Sydenham
authors.affiliation: Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Betina Hebbelstrup
authors.initials: BH
authors.lastname: Jensen
authors.affiliation: Department of Clinical Microbiology, Hvidovre University Hospital, Copenhagen, Denmark; Department of Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark.
authors.forename: Andreas Munk
authors.initials: AM
authors.lastname: Petersen
authors.affiliation: Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Karen Angeliki
authors.initials: KA
authors.lastname: Krogfelt
authors.affiliation: Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark.
authors.forename: Ulrik Stenz
authors.initials: US
authors.lastname: Justesen
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000382:microbiology; D001441:Bacteroides fragilis / Q000187:drug effects*; D002648:Child; D002981:Clindamycin / Q000627:therapeutic use; D003718:Denmark; D024881:Drug Resistance, Bacterial; D005243:Feces / Q000382:microbiology; D006801:Humans; D000077731:Meropenem; D008795:Metronidazole / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D064307:Microbiota / Q000187:drug effects*; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010878:Piperacillin / Q000627:therapeutic use; D000077725:Piperacillin, Tazobactam Drug Combination; D011795:Surveys and Questionnaires; D013845:Thienamycins / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D013845:Thienamycins; D008795:Metronidazole; D000077725:Piperacillin, Tazobactam Drug Combination; D002981:Clindamycin; D010397:Penicillanic Acid; D000077731:Meropenem; D010878:Piperacillin
keywords: Antimicrobial resistance; Bacteroides fragilis group; Children; Clindamycin; Faecal microbiota; Meropenem