title: Could knee inflammatory synovitis be induced by pembrolizumab?
abstract: Pembrolizumab, a selective anti-PD-1 humanized monoclonal antibody, reactivates T cells to fight cancer. Immune-related adverse events such as autoimmune colitis, pneumonitis, hepatitis, nephritis, hypophysitis, and thyroiditis may occur during, or weeks to months after therapy. Pemprolizumab-induced synovitis is rarely reported. With the wide use of immunotherapy to treat cancers, physicians need to be aware of this rare immune-related adverse event and provide immediate treatment to avoid permanent joint damage.
authors.affiliation: 1 Department of Internal Medicine, Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Fade
authors.initials: F
authors.lastname: Mahmoud
authors.affiliation: 2 Department of Orthopedics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Wilkinson
authors.affiliation: 3 Department of Rheumatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Gizinski
authors.affiliation: 4 Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Sanjaya
authors.initials: S
authors.lastname: Viswamitra
authors.affiliation: 5 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Neriman
authors.initials: N
authors.lastname: Gokden
authors.affiliation: 2 Department of Orthopedics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: John
authors.initials: J
authors.lastname: Vander Schilden
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008545:Melanoma / Q000188:drug therapy; D008875:Middle Aged; D013585:Synovitis / Q000139:chemically induced*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; C582435:pembrolizumab
keywords: Pemprolizumab; autoimmune arthritis; melanoma; synovitis