title: How are base excision DNA repair pathways deployedin vivo?
abstract: Since the discovery of the base excision repair (BER) system for DNA more than 40 years ago, new branches of the pathway have been revealed at the biochemical level byin vitrostudies. Largely for technical reasons, however, the confirmation of these subpathwaysin vivohas been elusive. We review methods that have been used to explore BER in mammalian cells, indicate where there are important knowledge gaps to fill, and suggest a way to address them.
authors.affiliation: Department of Pharmacological Sciences, Stony Brook University, School of Medicine, Stony Brook, NY, USA.
authors.forename: Upasna
authors.initials: U
authors.lastname: Thapar
authors.affiliation: Department of Pharmacological Sciences, Stony Brook University, School of Medicine, Stony Brook, NY, USA.
authors.forename: Bruce
authors.identifier: 0000-0001-9917-7479
authors.initials: B
authors.lastname: Demple
keywords: BER; Base excision repair; base excision repair pathways; in vivo studies; mammalian cells