title: Manganese-Based Nanogels as pH Switches for Magnetic Resonance Imaging.
abstract: pH-responsive nanogels (NGs) were used to prepare high-efficiency magnetic resonance imaging dual T1/T2contrast agents for pH imaging. The polymeric NG matrix acts as a strong polydentate ligand that chelates the Mn cations in its inner cavity generating a hybrid NG structure. The Mn chelate NG is sensitive to pH changes, such that protonation induces a change of the polymer hydration state and consequent swelling. The swollen nanogel allows water molecules to enter and interact with the Mn chelate, shortening the relaxation time (switch ON) and giving rise to positive or negative contrast on T1- or T2-weighted magnetic resonance images.
authors.affiliation: BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Universidad de Málaga , 29590 Málaga, Spain.|Departamento de Química Orgánica y Farmacéutica, Universidad de Sevilla , C/Profesor García González 2, 41012 Seville, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Caro
authors.affiliation: BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Universidad de Málaga , 29590 Málaga, Spain.|Networking Research Center on Bioengineering, Biomaterials and Nanomedicine , CIBER-BBN, 29590 Málaga, Spain.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: García-Martín
authors.affiliation: BIONAND, Andalusian Centre for Nanomedicine and Biotechnology, Universidad de Málaga , 29590 Málaga, Spain.|Departamento de Química Orgánica y Farmacéutica, Universidad de Sevilla , C/Profesor García González 2, 41012 Seville, Spain.
authors.forename: Manuel
authors.identifier: http://orcid.org/0000-0001-8160-0574
authors.initials: M
authors.lastname: Pernia Leal
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry* / Q000633:toxicity; D005782:Gels / Q000737:chemistry* / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D009457:Neuroglia / Q000187:drug effects; D051381:Rats
chemical_list: D003287:Contrast Media; D005782:Gels; D008345:Manganese