title: Friction forces position the neural anlage.
abstract: During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish embryo, friction forces are generated at the interface between anterior axial mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole and neurectoderm progenitors moving in the opposite direction towards the vegetal pole of the embryo. These friction forces lead to global rearrangement of cells within the neurectoderm and determine the position of the neural anlage. Using a combination of experiments and simulations, we show that this process depends on hydrodynamic coupling between neurectoderm and ppl as a result of E-cadherin-mediated adhesion between those tissues. Our data thus establish the emergence of friction forces at the interface between moving tissues as a critical force-generating process shaping the embryo.
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Smutny
authors.affiliation: Department of Biological Physics, Eötvös University, Pázmány Péter sétány 1A, Budapest H-1117, Hungary.
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Ákos
authors.affiliation: The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
authors.forename: Silvia
authors.initials: S
authors.lastname: Grigolon
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.
authors.forename: Shayan
authors.initials: S
authors.lastname: Shamipour
authors.affiliation: Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.|Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.
authors.forename: Verena
authors.initials: V
authors.lastname: Ruprecht
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.
authors.forename: Daniel
authors.initials: D
authors.lastname: Čapek
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Behrndt
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Papusheva
authors.affiliation: Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Masazumi
authors.initials: M
authors.lastname: Tada
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.
authors.forename: Björn
authors.initials: B
authors.lastname: Hof
authors.affiliation: Department of Biological Physics, Eötvös University, Pázmány Péter sétány 1A, Budapest H-1117, Hungary.
authors.forename: Tamás
authors.identifier: 0000-0003-1431-2884
authors.initials: T
authors.lastname: Vicsek
authors.affiliation: The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Salbreux
authors.affiliation: Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria.
authors.forename: Carl-Philipp
authors.initials: CP
authors.lastname: Heisenberg
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D015820:Cadherins / Q000378:metabolism; D002450:Cell Communication; D002465:Cell Movement; D004625:Embryo, Nonmammalian / Q000166:cytology; D004707:Endoderm / Q000166:cytology / Q000196:embryology; D017276:Friction; D054262:Gastrulation; D057446:Hydrodynamics; D008648:Mesoderm / Q000166:cytology / Q000196:embryology; D008954:Models, Biological; D009024:Morphogenesis; D009154:Mutation / Q000235:genetics; D009420:Nervous System / Q000196:embryology*; D054258:Neural Plate / Q000166:cytology / Q000196:embryology; D015027:Zebrafish / Q000196:embryology*; D029961:Zebrafish Proteins / Q000378:metabolism
chemical_list: D015820:Cadherins; D029961:Zebrafish Proteins