title: From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics.
abstract: The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), it has been much easier and faster to identify more toxins and predict their functions with bioinformatics pipelines, which pave the way for novel drug developments. Here we provide an overview of related bioinformatics pipelines that have been supported by a combination of transcriptomics and proteomics for identification and function prediction of novel marine toxins.
authors.affiliation: Venomics Research Group, BGI-Shenzhen, Shenzhen 518083, China. xiebing@genomics.cn.
authors.forename: Bing
authors.initials: B
authors.lastname: Xie
authors.affiliation: Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI, Shenzhen 518083, China. huangyu@genomics.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. kate.baumann@uqconnect.edu.au.
authors.forename: Kate
authors.initials: K
authors.lastname: Baumann
authors.affiliation: Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia 4072, Australia. bgfry@uq.edu.au.
authors.forename: Bryan Grieg
authors.initials: BG
authors.lastname: Fry
authors.affiliation: Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI, Shenzhen 518083, China. shiqiong@genomics.cn.|BGI Shenzhen Academy of Marine Sciences, BGI Fisheries, BGI, Shenzhen 518083, China. shiqiong@genomics.cn.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Shi
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D019295:Computational Biology / Q000379:methods; D006801:Humans; D008387:Marine Toxins / Q000737:chemistry* / Q000494:pharmacology*; D020543:Proteome / Q000187:drug effects*; D040901:Proteomics / Q000379:methods; D053719:Tandem Mass Spectrometry / Q000379:methods; D059467:Transcriptome / Q000187:drug effects*; D014688:Venoms / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D001688:Biological Products; D008387:Marine Toxins; D020543:Proteome; D014688:Venoms
keywords: database; marine toxins; proteome; transcriptome; venomics