title: Buyang Huanwu Decoction Ameliorates Poststroke Depression via Promoting Neurotrophic Pathway Mediated Neuroprotection and Neurogenesis.
abstract: Objective.The aim of the present research is to investigate the therapeutic effect of Buyang Huanwu Decoction (BHD) in poststroke depression (PSD) animal model and illustrate its underlying mechanism via promoting neurotrophic pathway mediated neuroprotection and neurogenesis.Methods.To induce PSD rat model, isolation housed rats that received middle cerebral artery occlusion (MCAO) surgery successively suffered from chronic mild stress (CMS) treatment for consecutive twenty-one days. Meanwhile, rats were correspondingly given vehicle, BHD, and fluoxetine. Then, neurologic function was scored and depressive-like behaviors were assessed by sucrose preference test, locomotor activity, novelty-suppressed feeding test, and forced swim test. Thereafter, the neuroprotection and neurogenesis related molecular markers and signaling were detected.Results.We firstly observed a significant neurological function recovery and antidepressants effect of BHD after MCAO together with CMS treatment. Our study also found that treatment with BHD and fluoxetine can significantly rescue neurons from apoptosis and promote neurogenesis in the CA3 and DG regions in the hippocampus. Notably, BHD and fluoxetine treatment can activate BDNF/ERK/CREB signaling.Conclusion.The results suggest that BHD is a promising candidate for treating PSD. Its curative effects can be attributed to neurotrophic pathway mediated neuroprotection and neurogenesis.
authors.affiliation: Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Luo
authors.affiliation: Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
authors.forename: Shuhua
authors.initials: S
authors.lastname: Deng
authors.affiliation: Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yi
authors.affiliation: Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
authors.forename: Sainan
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: She
authors.affiliation: Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; Yiyang Medical College, Yiyang, Hunan 413000, China.
authors.forename: Baiyan
authors.identifier: 0000-0002-2220-5459
authors.initials: B
authors.lastname: Liu