title: Sevoflurane affects evoked electromyography monitoring in cerebral palsy.
abstract: BACKGROUND
  To explore the effect of sevoflurane inhalation anesthesia on evoked electromyography monitoring of spinal nerve root in children associated with cerebral palsy.
  
  
  METHODS
  Children with cerebral palsy (n=40) were selected and further divided into 1MAC (minimum alveolar concentration) sevoflurane group and 2MAC sevoflurane group. Following the induction of anesthesia, Nicolet Endeavor-CR16 channel electrophysiological monitor was used to implement three times of successive electrical stimulation with interval of 5 sec at 3.50 mA.
  
  
  RESULTS
  Our results suggested a statistical significance of amplitude retention ratio and latency in the sevoflurane inhalation time (P<0.01), with an interaction effect between the sevoflurane inhalation time and concentration for amplitude retention ratio (P<0.01), while there is no interaction effect between the sevoflurane inhalation time and concentration for latency (P>0.05). Compared to 1MAC sevoflurane group, the amplitude retention ratio of 2MAC sevoflurane group decreased remarkably (P<0.01) and the latency of 2MAC sevoflurane group extended at T3 and T4 (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  In evoked electromyography monitoring of spinal nerve root in children with cerebral palsy, with the increasing of concentration and duration of sevoflurane inhalation, evoked electromyogram retention ratio reduces gradually, latency extends and the retention ratio has more changes than the latency.
authors.affiliation: Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, Jiangsu 223300, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, Jinan Military General Hospital, Jinan, China.
authors.forename: Lufeng
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, 223300, China.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, 223300, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Hepatobiliary & Pancreatic Surgery, Huai'an First Hospital, Nanjing Medical University, Huai'an 223000, China.
authors.forename: Yemu
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, Jiangsu 223300, China.
authors.forename: Jinyu
authors.initials: J
authors.lastname: Li
keywords: Sevoflurane; cerebral palsy; children; electromyography; spinal nerve root