title: Caspases rule the intracellular trafficking cartel.
abstract: During apoptosis, caspases feast on several hundreds of cellular proteins to orchestrate rapid cellular demise. Indeed, caspases are known to get a taste of every cellular process in one way or another, activating some, but most often shutting them down. Thus, it is not surprising that caspases proteolyze proteins involved in intracellular trafficking with particularly devastating consequences for this important process. This review article focuses on how caspases target the machinery responsible for smuggling goods within and outside the cell.
authors.affiliation: Institut de Pharmacologie de Sherbrooke, Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, QC, Canada.
authors.forename: Catherine
authors.initials: C
authors.lastname: Duclos
authors.affiliation: Institut de Pharmacologie de Sherbrooke, Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, QC, Canada.
authors.forename: Christine
authors.initials: C
authors.lastname: Lavoie
authors.affiliation: Institut de Pharmacologie de Sherbrooke, Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, QC, Canada.
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Denault
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D001692:Biological Transport / Q000502:physiology; D020169:Caspases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D022022:Nuclear Pore / Q000235:genetics / Q000378:metabolism; D059748:Proteolysis
chemical_list: D020169:Caspases
keywords: apoptosis; caspases; intracellular vesicle trafficking; nuclear pore complex; proteases; proteolysis