title: Waldenström Macroglobulinemia: Review of Pathogenesis and Management.
abstract: Waldenström macroglobulinemia (WM) is a low-grade B-cell clonal disorder characterized by lymphoplasmacytic bone marrow involvement associated with monoclonal immunoglobulin M. Although WM remains to be an incurable disease with a heterogeneous clinical course, the recent discovery of mutations in the MYD88 and CXCR4 genes further enhanced our understanding of its pathogenesis. Development of new therapies including monoclonal antibodies, proteasome inhibitors, and Bruton tyrosine kinase inhibitors have made the management of WM increasingly complex. Treatment should be tailored to the individual patient while considering many clinical factors. The clinical outcomes are expected to continue to improve, given the emergence of novel therapeutics and better understanding of the underlying pathogenesis.
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ; Department of Hematology and Oncology, H. Lee Moffitt Cancer Center, Tampa, FL.
authors.forename: Seongseok
authors.initials: S
authors.lastname: Yun
authors.affiliation: University of Arizona College of Medicine, Tucson, AZ.
authors.forename: Ariel C
authors.initials: AC
authors.lastname: Johnson
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ.
authors.forename: Onyemaechi N
authors.initials: ON
authors.lastname: Okolo
authors.affiliation: Division of Pathology, Department of Medicine, University of Arizona, Tucson, AZ.
authors.forename: Stacy J
authors.initials: SJ
authors.lastname: Arnold
authors.affiliation: College of Pharmacy, University of Arizona, Tucson, AZ.
authors.forename: Ali
authors.initials: A
authors.lastname: McBride
authors.affiliation: Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center, Tampa, FL.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Hematology and Oncology, H. Lee Moffitt Cancer Center, Tampa, FL.
authors.forename: Rachid C
authors.initials: RC
authors.lastname: Baz
authors.affiliation: Division of Hematology, Oncology, Blood, and Marrow Transplantation, Department of Medicine, University of Arizona, Tucson, AZ. Electronic address: anwerf@email.arizona.edu.
authors.forename: Faiz
authors.initials: F
authors.lastname: Anwer
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D000970:Antineoplastic Agents
keywords: CXCR4; Lymphoid neoplasm; Lymphoplasmacytic lymphoma; MYD88; Monoclonal immunoglobulin M