title: Systemic therapies and cognitive impairment for breast cancer: an overview of the current literature.
abstract: Both endocrine and chemotherapy can be utilized for breast cancer patients' management, in multiple setting (i.e., primary systemic therapy, adjuvant, metastatic treatment). Health-related quality of life in breast cancer survivors can be significantly influenced by cognitive impairment, which has been related in several previously reported experiences to systemic therapies administration. However, although the growing body of literature, the impact of both chemo- and endocrine therapy on cognitive function is currently unclear, due to many confounding factors (i.e., multiple therapies, duration of therapy, comorbidity, age). The aim of the present review is to present an overview of the current literature concerning the possible influence of endocrine and systemic therapy on breast cancer patients' cognitive impairment.
authors.affiliation: Azienda Ospedaliero Universitaria Careggi - University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy. icro.meattini@unifi.it.
authors.forename: Icro
authors.identifier: http://orcid.org/0000-0002-1861-2895
authors.initials: I
authors.lastname: Meattini
authors.affiliation: Azienda Ospedaliero Universitaria Careggi - University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy.
authors.forename: Isacco
authors.initials: I
authors.lastname: Desideri
authors.affiliation: Azienda Ospedaliero Universitaria Careggi - University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Francolini
authors.affiliation: Azienda Ospedaliero Universitaria Careggi - University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy.
authors.forename: Agnese
authors.initials: A
authors.lastname: Vannini
authors.affiliation: Azienda Ospedaliero Universitaria Careggi - University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Perna
authors.affiliation: Azienda Ospedaliero Universitaria Careggi - University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Garlatti
authors.affiliation: Azienda Ospedaliero Universitaria Careggi - University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Grassi
authors.affiliation: Azienda Ospedaliero Universitaria Careggi - University of Florence, Largo G.A. Brambilla 3, 50134, Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Livi
mesh_terms: D001943:Breast Neoplasms / Q000523:psychology* / Q000628:therapy*; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans
keywords: Breast cancer; Cognitive impairment; Endocrine therapy; Quality of life; Systemic therapy