title: Two new phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity.
abstract: A new biphenyl-furocoumarin, named morescoumarin A (1), and a new prenylated flavanone, named morflavanone A (2) were isolated from the root bark of Morus alba L., together with four known compounds (3-6). Their structures were determined by extensive spectroscopic analyses and comparison with literature data. The cardioprotective effects of these compounds against doxorubicin-induced cell death were evaluated by MTT method.
authors.affiliation: a School of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.|b School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou , P.R. China.
authors.forename: Yan-Gang
authors.initials: YG
authors.lastname: Cao
authors.affiliation: b School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou , P.R. China.
authors.forename: Xiao-Ke
authors.initials: XK
authors.lastname: Zheng
authors.affiliation: b School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou , P.R. China.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yang
authors.affiliation: b School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou , P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: b School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou , P.R. China.
authors.forename: Man
authors.initials: M
authors.lastname: Qi
authors.affiliation: b School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou , P.R. China.
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: b School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou , P.R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: a School of Pharmacy , Heilongjiang University of Chinese Medicine , Harbin , P.R. China.
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
authors.affiliation: b School of Pharmacy , Henan University of Chinese Medicine , Zhengzhou , P.R. China.
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Feng
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D032383:Myocytes, Cardiac / Q000187:drug effects; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D054876:Prenylation; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D002316:Cardiotonic Agents; D044950:Flavanones; D010636:Phenols
keywords: Moraceae; Morus alba L; cardioprotective effect; phenolic constituents