title: Xanthogranuloma of the sellar region diagnosed by frozen section.
abstract: Xanthogranuloma (XG) of the sellar region is uncommon and is difficult to diagnose based on intraoperative frozen sections. This study is a case presentation and review of the literature, highlighting the need to explore underlying diseases in order to guarantee an accurate patient diagnosis. Herein, we presented the case of a 43-year-old woman who was afflicted with xanthogranuloma of the sellar region; the patient had a history of headache and lengthened menstrual cycles over the 6 months prior to presentation. Endocrinology tests revealed that the patient's levels of prolactin were high and the MRI of the patient showed a clearly defined sellar mass. As a result, the patient was considered to have prolactinoma prior to undergoing surgery. The tumor was completely removed using a transsphenoidal approach, and intraoperative frozen section revealed histology similar to xanthogranuloma. When the tumor was removed by surgical operation, the patient's visual field defects and headache were relieved. Although intraoperative frozen section should provide some guidance with regard to the diagnosis, a pathological study is conducted to confirm the actual diagnosis.
authors.affiliation: Department of Pathophysiology, Shenyang Medical College, Shenyang 110034, Liaoning, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Ji
authors.affiliation: Department of Pathophysiology, Shenyang Medical College, Shenyang 110034, Liaoning, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of health Sciences Research, Mayo Clinic College of Medicine, Rochester 55901, Minnesota, United States of America.
authors.forename: Liwei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Departments of Neurosurgery, The Second Clinical Medical School of Inner Mongolia University for the Nationalities (Inner Mongolia General Forestry Hospital), Yakeshi 022150, Inner Mongolia, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
keywords: Frozen section; Sellar tumor; Sellar xanthogranuloma; Xanthogranuloma