title: Association between serum uric acid and cardiovascular mortality and all-cause mortality: a cohort study.
abstract: Previous studies have reported the association among serum uric acid (SUA) levels and cardiovascular and all-cause mortality; however, the results have been inconsistent. The aim of this study was to investigate whether SUA is independently associated with cardiovascular and all-cause mortality in relatively healthy Korean adults.
  
  
  
  A total of 396 951 individuals were enrolled for the study between 2002 and 2012. About 39 991 participants were excluded for various reasons. All-cause and cardiovascular mortality data were collected. Cox proportional hazards models were used to estimate adjusted hazard ratios and 95% confidence intervals for all-cause and cardiovascular mortality according to baseline uric acid quintiles, and the third, middle SUA quintile was the reference group.
  
  
  
  A total of 356 960 participants were considered to be eligible for the analysis, and median follow-up duration was 5.88 years. The lowest and highest quintiles of SUA were less than 5.2 and more than 7.1 mg/dl in men, and less than 3.5 and more than 5.0 mg/dl in women, respectively. A total of 2082 deaths (312 from cardiovascular disease and 1770 from other causes) occurred during follow-up. In the highest SUA group, adjusted hazard ratios for all-cause mortality were 1.24 (1.01, 1.51) in men and 1.04 (0.76, 1.42) in women, and for cardiovascular mortality were 1.15 (0.72, 1.83) in men and 1.69 (0.70, 4.04) in women after adjustment for various possible confounding factors.
  
  
  
  In the current large relatively healthy population-based observational study, SUA showed no significant association with all-cause and cardiovascular mortality.
authors.affiliation: aDivision of Cardiology, Department of Medicine bDepartment of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine cDepartment of Internal Medicine, EunpyeongTeunTeun Hospital dDepartment of Medicine/Cardiology, Cheil General Hospital, Dankook University College of Medicine, Seoul, Republic of Korea.
authors.forename: EunSun
authors.initials: E
authors.lastname: Cheong
authors.forename: Seungho
authors.initials: S
authors.lastname: Ryu
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Joo-Wook
authors.initials: JW
authors.lastname: Sung
authors.forename: Dong-Sik
authors.initials: DS
authors.lastname: Cho
authors.forename: Jeong Bae
authors.initials: JB
authors.lastname: Park
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000401:mortality*; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid