title: Profile of adult acute cholinesterase inhibitors substances poisoning - a 30 years analysis.
abstract: OBJECTIVE
  The objective of this study was to assess the pattern and outcome of acute cholinesterase inhibitors substances (CIS) poisoning cases, in a cohort from a regional tertiary care hospital.
  
  
  METHODS
  cases admitted in the Toxicology Clinic of "Sf. Spiridon" Emergency Clinic Hospital Iasi, Romania between 1983 and 2013 were studied.
  
  
  RESULTS
  a total number of 606 patients were included. The reason for exposures was intentional in 70% of cases and the commonest route of poisoning was oral in 92.2%. The highest percent of cases was females (56.4), the age group 20-29 (25.4%) and the majority (66.7%) coming from rural areas, 28.2% being agricultural workers. 36.6% of cases were severe clinical forms. Overall mortality rates were 3.8%, more than half of the death patients (65.2%) had concomitant alcohol intake. It was a significant statistical association between decrease level of serum cholinesterase on admittance and severe forms (p 0.000) and between survival and deaths groups (p 0.000). The pattern of poisoning described by our retrospective study suggests that CIS poisoning are mainly preventable. The main effective goals for prevention are restriction in free accessibility to toxic pesticides, together with sustained efforts in education concerning the life-threatening danger of pesticide poisoning.
authors.affiliation: "Sf. Spiridon" Emergency Clinic Hospital, Internal Medicine and Toxicology Department, School of Medicine "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Eugen N
authors.initials: EN
authors.lastname: Gazzi
authors.affiliation: "Sf. Spiridon" Emergency Clinic Hospital, Internal Medicine and Toxicology Department, School of Medicine "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania, Tel: +40728040582.
authors.forename: Victorita
authors.initials: V
authors.lastname: Sorodoc
authors.affiliation: Pharmacology - Toxicology Department, Faculty of Medicine, "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Irina M
authors.initials: IM
authors.lastname: Jaba
authors.affiliation: "Sf. Spiridon" Emergency Clinic Hospital, Internal Medicine and Toxicology Department, School of Medicine "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Catalina
authors.initials: C
authors.lastname: Lionte
authors.affiliation: "Sf. Spiridon" Emergency Clinic Hospital, Internal Medicine and Toxicology Department, School of Medicine "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bologa
authors.affiliation: Pharmacology - Toxicology Department, Faculty of Medicine, "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Catalina E
authors.initials: CE
authors.lastname: Lupusoru
authors.affiliation: Physiopathology Department, Faculty of Medicine, "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Raoul
authors.initials: R
authors.lastname: Lupusoru
authors.affiliation: "Sf. Spiridon" Emergency Clinic Hospital, Internal Medicine and Toxicology Department, School of Medicine "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Laurentiu
authors.initials: L
authors.lastname: Sorodoc
authors.affiliation: "Sf. Spiridon" Emergency Clinic Hospital, Internal Medicine and Toxicology Department, School of Medicine "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Petris
keywords: Epidemiology; pesticide; toxicity