title: Paediatric systemic lupus erythematosus: insights from translational research.
abstract: Investigations in paediatric SLE contributed significantly to the discovery of the association of type I IFNs with lupus and underscored the potential application of this knowledge by informing the use of glucocorticoid therapy. Recent, promising research reveals biomarkers that may yield more focused clinical monitoring and assessment of response to treatment. This article reviews unique features of paediatric SLE and details important developments in paediatric lupus research.
authors.affiliation: Pediatric Rheumatology, University of Texas Southwestern Medical Center.|Rheumatology, Texas Scottish Rite Hospital for Children.|Pediatric Rheumatology, Children's Medical Center of Dallas, Dallas, TX, USA.
authors.forename: Tracey B
authors.initials: TB
authors.lastname: Wright
authors.affiliation: Pediatric Rheumatology, University of Texas Southwestern Medical Center.|Rheumatology, Texas Scottish Rite Hospital for Children.|Pediatric Rheumatology, Children's Medical Center of Dallas, Dallas, TX, USA.
authors.forename: Marilynn
authors.initials: M
authors.lastname: Punaro
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D015415:Biomarkers; D002648:Child; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D057170:Translational Research, Biomedical
chemical_list: D015415:Biomarkers; D005938:Glucocorticoids; D007370:Interferon Type I
keywords: biomarker; microarray; paediatric; systemic lupus erythematosus