title: Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment-Controlled Multistage Drug-Release in Neurons.
abstract: Innovative nanoparticles hold promising potential for disease therapy as drug delivery systems. For brain-disease therapy, a drug delivery system that can sustainably control drug-release and monitor fluorescence of the drug cargos is highly desirable. In this study, a light-traceable and intracellular microenvironment-responsive drug delivery system was developed based on the combination of glutathione-responsive autoflurescent nanogel, dendrimer-like mesoporous silica nanoparticles, and gold nanoparticles. The resulting hybrid nanoparticles represent a new class of delivery system that can efficiently load, transport, and control multistage-release of sulfydryl-containing drugs into neurons, with light-traceable monitoring for future brain-disease therapy.
authors.affiliation: College of Life Sciences, Henan University, Jin Ming Avenue, Kaifeng, Henan, 475004, China.
authors.forename: Bingyang
authors.initials: B
authors.lastname: Shi
authors.affiliation: Department of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing, 100083, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.affiliation: College of Life Sciences, Henan University, Jin Ming Avenue, Kaifeng, Henan, 475004, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.affiliation: Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
authors.forename: Libing
authors.initials: L
authors.lastname: Fu
authors.affiliation: Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
authors.forename: Marco
authors.initials: M
authors.lastname: Morsch
authors.affiliation: Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
authors.forename: Albert
authors.initials: A
authors.lastname: Lee
authors.affiliation: Institute of Advanced Materials for Nano-Bio Applications, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Cole
authors.affiliation: Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, 2109, Australia.
authors.forename: Roger
authors.initials: R
authors.lastname: Chung
mesh_terms: D000818:Animals; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D002460:Cell Line; D060833:Cellular Microenvironment; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005453:Fluorescence; D042541:Intracellular Space / Q000378:metabolism*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide
keywords: multistage controlled release; neurons; responsive drug delivery; sulfydryl-containing drugs; traceable drug delivery