title: Long-Term Neurodevelopmental and Growth Outcomes of Premature Infants Born at <29 week Gestational Age with Post-Hemorrhagic Hydrocephalus Treated with Ventriculo-Peritoneal Shunt.
abstract: OBJECTIVE
  To compare long-term neurodevelopmental and growth (NDG) outcomes at 3 y corrected gestational age (GA) in premature infants with grade ≥ III intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus who were treated with ventriculo-peritoneal shunt with those who were not treated with shunt.
  
  
  METHODS
  In a retrospective cohort study, NDG outcomes were compared between preterm infants of <29 wk GA with IVH treated with shunt (IVHS) and IVH with no shunt (IVHNS). This was a single centre study. The primary outcome was moderate to severe cerebral palsy (CP).
  
  
  RESULTS
  Of 1762 preterm infants who survived to discharge, 90 had grade ≥ III IVH. Infants in IVHS group had more grade IV IVH than IVHNS (p < 0.05). Seventy percent of the patients in IVHNS groups had no hydrocephalus. IVHS group had increased CP (76% vs. 30%; p 0.003), and higher odds of CP after controlling for GA and IVH grade [odds ratio (OR); 4.23 (1.38 to 13.00)]. Growth delay was not different between groups.
  
  
  CONCLUSIONS
  Infants with IVHS are at increased risk of CP but not growth delay.
authors.affiliation: Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Diwakar
authors.affiliation: Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.|Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.|Section of Pediatric Neurosurgery, Department of Surgery, University of Calgary, Calgary, Alberta, Canada.|Alberta Health Services, Calgary, Alberta, Canada.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Hader
authors.affiliation: Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.|Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada.|Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.|Alberta Health Services, Calgary, Alberta, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Soraisham
authors.affiliation: Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.|Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.|Alberta Health Services, Calgary, Alberta, Canada.
authors.forename: Harish
authors.initials: H
authors.lastname: Amin
authors.affiliation: Alberta Health Services, Calgary, Alberta, Canada.
authors.forename: Selphee
authors.initials: S
authors.lastname: Tang
authors.affiliation: Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.|Alberta Health Services, Calgary, Alberta, Canada.
authors.forename: Kelly
authors.initials: K
authors.lastname: Bullivant
authors.affiliation: Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.|Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.|Alberta Health Services, Calgary, Alberta, Canada.
authors.forename: Majeeda
authors.initials: M
authors.lastname: Kamaluddeen
authors.affiliation: Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada. aklodha@ucalgary.ca.|Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. aklodha@ucalgary.ca.|Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada. aklodha@ucalgary.ca.|Alberta Health Services, Calgary, Alberta, Canada. aklodha@ucalgary.ca.|Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. aklodha@ucalgary.ca.|Department of Pediatrics, Cumming School of Medicine, Foothills Medical Centre, C211-1403 29 St NW, Calgary, AB,, T2N2T9, Canada. aklodha@ucalgary.ca.
authors.forename: Abhay
authors.initials: A
authors.lastname: Lodha
mesh_terms: D000074042:Cerebral Intraventricular Hemorrhage / Q000150:complications*; D002547:Cerebral Palsy / Q000209:etiology; D002657:Child Development; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology* / Q000628:therapy; D062071:Infant, Extremely Premature / Q000254:growth & development; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy; D008297:Male; D012189:Retrospective Studies; D017287:Ventriculoperitoneal Shunt
keywords: Hydrocephalus; Intraventricular hemorrhage; Neurodevelopmental outcome; Preterm infants