title: A new anthraquinone and a new naphthoquinone from the whole plant of Spermacoce latifolia.
abstract: A phytochemical study on the whole plant of Spermacoce latifolia led to the isolation of a new anthraquinone, 1,2,6-trihydroxy-5-methoxy-9,10-anthraquinone (1), and a new naphthoquinone, (2R)-6-hydroxy-7-methoxy-dehydroiso-α-lapachone (2), together with three known anthraquinones (3-5). Their structures were established on the basis of detailed spectroscopic analysis, including one- and two-dimensional NMR, ESI-MS, and HR-ESI-MS techniques. All the compounds were isolated from S. latifolia for the first time. Compounds 1, 2, 4, and 5 showed significant antibacterial activity toward Bacillus subtilis with MIC values ranging from 0.9 to 31.2 μg/ml, and compound 4 aslo exhibited antibacterial activity against Bacillus cereus with a MIC value 62.5 μg/ml. Compound 1 was further revealed to show significant in vitro α-glucosidase inhibitory activity with IC50value of 0.653 mM.
authors.affiliation: a School of Pharmacy and Biological Sciences, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department Document (Approval Number: 2014-405)] , University of South China , Hengyang 421001 , China.|b Guangdong Provincial Key Laboratory of Applied Botany, South China Botanic Garden , Chinese Academy of Sciences , Guangzhou 510650 , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: c Institute of Pathogenic Biology , University of South China , Hengyang 421001 , China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Shen
authors.affiliation: d Department of Gynaecology and Obstetrics, the Second Affiliated Hospital , University of South China , Hengyang 421001 , China.
authors.forename: Qing-Xiang
authors.initials: QX
authors.lastname: Shen
authors.affiliation: a School of Pharmacy and Biological Sciences, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department Document (Approval Number: 2014-405)] , University of South China , Hengyang 421001 , China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Cao
authors.affiliation: a School of Pharmacy and Biological Sciences, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department Document (Approval Number: 2014-405)] , University of South China , Hengyang 421001 , China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: a School of Pharmacy and Biological Sciences, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department Document (Approval Number: 2014-405)] , University of South China , Hengyang 421001 , China.
authors.forename: Shi-Yin
authors.initials: SY
authors.lastname: Long
authors.affiliation: a School of Pharmacy and Biological Sciences, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [Hunan Provincial Education Department Document (Approval Number: 2014-405)] , University of South China , Hengyang 421001 , China.
authors.forename: Zong-Bao
authors.initials: ZB
authors.lastname: Wang
authors.affiliation: b Guangdong Provincial Key Laboratory of Applied Botany, South China Botanic Garden , Chinese Academy of Sciences , Guangzhou 510650 , China.
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Tan
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019666:Rubiaceae / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000187:drug effects; D012762:Shigella dysenteriae / Q000187:drug effects; D000520:alpha-Glucosidases / Q000187:drug effects
chemical_list: C000622335:1,2,6-trihydroxy-5-methoxy-9,10-anthraquinone; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D065089:Glycoside Hydrolase Inhibitors; D009285:Naphthoquinones; D000520:alpha-Glucosidases
keywords: Rubiaceae; Spermacoce latifolia; anthraquinone; antibacterial activity; naphthoquinone; α-glucosidase inhibitor