title: Pushing Yap into the Nucleus with Shear Force.
abstract: Endothelial cells line blood vessels and experience shear stress from blood flow. In this issue of Developmental Cell, Nakajima and colleagues (2017) show that in zebrafish Yap responds to blood flow by translocating into the nucleus, where it drives a genetic program to maintain vascular stability.
authors.affiliation: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Electronic address: jason.lai@mpi-bn.mpg.de.
authors.forename: Jason Kuan Han
authors.initials: JK
authors.lastname: Lai
authors.affiliation: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Electronic address: didier.stainier@mpi-bn.mpg.de.
authors.forename: Didier Y R
authors.initials: DY
authors.lastname: Stainier
mesh_terms: D000818:Animals; D002467:Cell Nucleus; D042783:Endothelial Cells; D004727:Endothelium; D013314:Stress, Mechanical; D015027:Zebrafish