title: Evaluation of Overactive Bladder in Male Antidepressant Users: A Prospective Study.
abstract: OBJECTIVE
  In this study, we investigated overactive bladder (OAB) functions in male patients who used antidepressant drugs (ADs) that were previously examined in female patients, based on conflicting data in literature regarding the effects of AD on OAB and the differences between male and female urinary system physiologies (anatomical and hormonal).
  
  
  METHODS
  The study included 202 male patients (a control group of 90 healthy subjects, and an experimental group of 112 patients taking ADs for different disorders). All the patients completed the overactive bladder-validated 8 (OAB-V8) questionnaire, the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), and the Beck Depression Inventory (BDS).
  
  
  RESULTS
  The OAB-V8, ICIQ-SF, and BDS scores for the antidepressant users were significantly higher than those of the control group. The highest prevalence of OAB symptoms was observed in patients taking venlafaxine (68.2%), and the lowest prevalence was in patients taking sertraline (28.0%). Moreover, the frequency of OAB between the antidepressant groups was statistically significant. The univariate logistic regression analyses showed a significant relationship between the presence of OAB, antidepressant usage, BDS score, and the age of a patient. In the multivariate logistic regression analyses, the association between the presence of OAB and antidepressant usage was statistically significant.
  
  
  CONCLUSIONS
  The present study showed that the incidence of OAB and the severity of OAB symptoms increased in males using antidepressants for various disorders. This may have been due to unique pharmacological effects, on a molecular or individual level, of serotonin-norepinephrine reuptake inhibitors.
authors.affiliation: Department of Neurology, Faculty of Medicine, Trakya University, Edirne, Turkey.
authors.forename: Volkan
authors.identifier: 0000-0002-9045-2347
authors.initials: V
authors.lastname: Solmaz
authors.affiliation: Department of Urology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
authors.forename: Sebahattin
authors.identifier: 0000-0002-4247-7064
authors.initials: S
authors.lastname: Albayrak
authors.affiliation: Department of Neurology, Faculty of Medicine, Trakya University, Edirne, Turkey.
authors.forename: Arslan
authors.identifier: 0000-0002-7197-2902
authors.initials: A
authors.lastname: Tekatas
authors.affiliation: Department of Neurology, Gaziosmanpaşa Universty Medical Faculty, Tokat, Turkey.
authors.forename: Dürdane
authors.identifier: 0000-0002-9228-3049
authors.initials: D
authors.lastname: Aksoy
authors.affiliation: Department of Urology, Idıl State Hospital, Konya, Turkey.
authors.forename: Yusuf
authors.identifier: 0000-0002-2554-267X
authors.initials: Y
authors.lastname: Gençten
authors.affiliation: Tokat Mental and Neurological Diseases Hospital, Tokat, Turkey.
authors.forename: Sema
authors.identifier: 0000-0002-3136-0741
authors.initials: S
authors.lastname: İnanır
authors.affiliation: Department of Urology, Faculty of Medicine, Gaziosmanpaşa Universty, Tokat, Turkey.
authors.forename: Fikret
authors.identifier: 0000-0002-3744-1681
authors.initials: F
authors.lastname: Erdemir
keywords: Antidepressive Agents; Urinary Bladder, Overactive; Validation Studies