title: Regulatory B Cells and Allergy: Uncovering the Link.
abstract: Regulatory B (Breg) cells are recognized as immunosuppressive cells. During the last few years, several subsets of Breg cells with different phenotypes and suppressive mechanisms have been described in the literature. We review the role of Breg cells in allergy based on an extensive literature search in PubMed. We describe the types and mechanisms of action of B cells and their role in the pathogenesis of several allergic diseases (allergic asthma, allergic rhinitis, food allergy, contact hypersensitivity, and anaphylaxis).
authors.affiliation: Immunoallergy Department, CUF Descobertas Hospital, Lisbon, Portugal.
authors.forename: I
authors.initials: I
authors.lastname: Mota
authors.affiliation: CEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School|FCM, Universidade Nova de Lisboa, Lisbon, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Martins
authors.affiliation: Immunoallergy Department, CUF Descobertas Hospital, Lisbon, Portugal.|CEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School|FCM, Universidade Nova de Lisboa, Lisbon, Portugal.
authors.forename: L M
authors.initials: LM
authors.lastname: Borrego
mesh_terms: D006801:Humans; D060151:B-Lymphocytes, Regulatory / Q000276:immunology; D006967:Hypersensitivity / Q000276:immunology; D000818:Animals
keywords: Allergen tolerance; Allergic disease; Allergy; Asthma; B10; Br1; Food allergy; Hymenoptera venom allergy; Pregnancy; Regulatory B cells