title: Myeloperoxidase-positive cell infiltration of normal colorectal mucosa is related to body fatness and is predictive of adenoma occurrence.
abstract: Body fatness is a risk factor for colorectal cancer, and promotes an inflammatory environment. Indeed, inflammation in normal colorectal mucosa may be a factor linking body fatness to colorectal carcinogenesis. In this study, we evaluated myeloperoxidase (MPO)-positive cells infiltration of normal colorectal mucosa as a marker of cancer-promoting inflammation in overweight and obese subjects. One hundred and three subjects with normal colonoscopy entered the study. Waist circumference (WC) and body mass index (BMI) were measured, and MPO-positive cells on histological sections of biopsies of normal colorectal mucosa were counted under a light microscope. The occurrence of adenomas was then evaluated on follow-up colonoscopies. Mean MPO-positive cell count (±s.e.m.) was higher in subject with a WC equal or above the obesity cutoff values according to gender (2.63±0.20 vs 2.06±0.18, P=0.03), and in subjects with BMI equal or above 25 kg m-2(2.54±0.18 vs 1.97±0.20, P=0.03). A Cox proportional hazard model showed that mean MPO-positive cell count in normal colorectal mucosa was the only factor independently related to occurrence of adenomas in follow-up colonoscopies. Though preliminary, these results show that MPO-positive cell infiltration in normal colorectal mucosa is related with body fatness, as evaluated by WC and BMI, and it may be considered a useful and simple marker to estimate adenoma occurrence risk.
authors.affiliation: Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Modena, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Mariani
authors.affiliation: Department of Medicine, Emergency Medicine and Medical Specialties, Endoscopy Unit, Policlinico, Modena, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Boarino
authors.affiliation: Department of Medicine, Emergency Medicine and Medical Specialties, Endoscopy Unit, Policlinico, Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bertani
authors.affiliation: Department of Medicine, Emergency Medicine and Medical Specialties, Endoscopy Unit, Policlinico, Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Merighi
authors.affiliation: Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Modena, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pedroni
authors.affiliation: Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Modena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.affiliation: Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Modena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Mancini
authors.affiliation: Department of Biomedical, Metabolic and Neural Sciences, Section of Human Morphology, University of Modena and Reggio Emilia, Policlinico, Modena, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Sena
authors.affiliation: Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Modena, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Benatti
authors.affiliation: Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Policlinico, Modena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Roncucci
mesh_terms: D000236:Adenoma / Q000201:enzymology* / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D015992:Body Mass Index; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000378:metabolism; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007249:Inflammation / Q000201:enzymology* / Q000378:metabolism; D007413:Intestinal Mucosa; D007558:Italy; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D050177:Overweight / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D009195:Peroxidase / Q000378:metabolism*; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D009195:Peroxidase