title: Applications of Lawesson's reagent in the synthesis of naturally occurring steroids and terpenoids.
abstract: Steroids and terpenoids are among the most biologically significant classes of natural products possessing a variety of biological activities. The replacement of one or more oxygen atoms in a steroid or terpenoid molecule by a heteroatom affects the chemical properties of that particular steroid or terpenoid, and that replacement often results in alterations of its biological properties, which is sometimes valuable. One possible modification is the thionation that could have some influence on such activity. Among the various thionating reagents, Lawesson's reagent was found to be most suitable and showed versatile properties, including chemoselectivity and functional group tolerance. In this review, we present the role of Lawesson's reagent in the synthesis of thioanalogues of natural steroids and terpenoids.
authors.affiliation: a Department of Chemistry , Quaid-I-Azam University , Islamabad 45320 , Pakistan.
authors.forename: Aamer
authors.initials: A
authors.lastname: Saeed
authors.affiliation: a Department of Chemistry , Quaid-I-Azam University , Islamabad 45320 , Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Mehfooz
authors.affiliation: a Department of Chemistry , Quaid-I-Azam University , Islamabad 45320 , Pakistan.
authors.forename: Fayaz Ali
authors.initials: FA
authors.lastname: Larik
authors.affiliation: a Department of Chemistry , Quaid-I-Azam University , Islamabad 45320 , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Faisal
authors.affiliation: a Department of Chemistry , Quaid-I-Azam University , Islamabad 45320 , Pakistan.
authors.forename: Pervaiz Ali
authors.initials: PA
authors.lastname: Channar
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D007202:Indicators and Reagents; D009946:Organothiophosphorus Compounds; D013256:Steroids; D013729:Terpenes; C029887:2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide
keywords: Lawesson’s reagent; steroids; terpenoids; thionation