title: Clinical significance of platelet-derived growth factor receptor-β gene expression in stage II/III gastric cancer with S-1 adjuvant chemotherapy.
abstract: Overall survival remains unsatisfactory in stage II/III gastric cancer, even after curative surgery and adjuvant chemotherapy. Platelet-derived growth factor receptor-β (PDGFR-β) is associated with the proliferation of cancer cells. The present study therefore investigated the association ofPDGFR-β gene expression with patient outcome in 134 stage II/III gastric cancer patients who received adjuvant chemotherapy with S-1. RelativePDGFR-β gene expression was measured in surgical cancer tissue and adjacent normal mucosa specimens by reverse transcription-quantitative polymerase chain reaction. ThePDGFR-β gene expression levels were found to be significantly higher in the cancer tissues compared with the adjacent normal mucosa. A high level ofPDGFR-β gene expression was associated with a significantly poorer 5-year overall survival rate compared with a low level ofPDGFR-β expression. Upon multivariate analysis,PDGFR-β gene expression was found to be an independent predictor of survival. Overall, the study indicates thatPDGFR-β overexpression in gastric cancer tissues is a useful independent predictor of outcome in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1.
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Higuchi
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Oshima
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoshihara
authors.affiliation: Clinical Research Coordinating Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Sakamaki
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Aoyama
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Suganuma
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamamoto
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Cho
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Shiozawa
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Takaki
authors.initials: T
authors.lastname: Yoshikawa
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.affiliation: Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, Japan.
authors.forename: Chikara
authors.initials: C
authors.lastname: Kunisaki
authors.affiliation: Department of Surgery, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Kanagawa 234-8503, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Imada
authors.affiliation: Department of Surgery, Yokohama City University, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
keywords: PDGFR-β; adjuvant chemotherapy with S-1; prognostic factor; stage II/III gastric cancer; tyrosine kinase receptor