title: Synthesis and characterization of polyvinyl alcohol- carboxymethyl tamarind gum based composite films.
abstract: The present study delineates the synthesis of novel composite films using polyvinyl alcohol and carboxymethyl tamarind gum. The microscopic study results confirmed the formation of composite matrices. FTIR spectroscopy suggested the occurrence of hydrogen-bonding amongst the components of the films. The extent of hydrogen bonding was composition-dependent which reached a critical higher limit at a particular composition. At the critical composition, the instantaneous and the intermediate polymer relaxation time were longer. All the films were found to be viscoelastic in nature. The melting endotherm was also highest for the composition described above. Ciprofloxacin loaded films showed excellent antimicrobial property against E. coli, suggesting that the drug was released in its active form. Cell proliferation study using human keratinocytes suggested better cell proliferation in the CMT containing films as compared to the control (PVA only) film. In gist, the developed films can be explored for skin tissue engineering and drug delivery applications.
authors.affiliation: Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, 769008, India.
authors.forename: Indu
authors.initials: I
authors.lastname: Yadav
authors.affiliation: Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, 769008, India.
authors.forename: V S Sharan
authors.initials: VS
authors.lastname: Rathnam
authors.affiliation: Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, 769008, India.
authors.forename: Yamini
authors.initials: Y
authors.lastname: Yogalakshmi
authors.affiliation: Department of Ceramic Engineering, National Institute of Technology, Rourkela, 769008, India.
authors.forename: Subhabrata
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, 769008, India. Electronic address: indraniliit@gmail.com.
authors.forename: Indranil
authors.initials: I
authors.lastname: Banerjee
authors.affiliation: Department of Chemical Engineering, King Saud University, Riyadh, 11421, Saudi Arabia. Electronic address: aarfat@ksu.edu.sa.
authors.forename: Arfat
authors.initials: A
authors.lastname: Anis
authors.affiliation: Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, 769008, India. Electronic address: kpal.nitrkl@gmail.com.
authors.forename: Kunal
authors.initials: K
authors.lastname: Pal
keywords: Carboxymethyl tamarind gum; Composite films; Drug delivery; Polyvinyl alcohol; Skin tissue engineering