title: Can Locoregionally Recurrent Breast Cancer Be Cured?
abstract: Locoregional recurrence (LRR) of breast cancer can occur after multidisciplinary treatment of a primary breast cancer. With modern multidisciplinary breast cancer treatment, the incidence of isolated LRR is decreasing. Improvements in systemic therapy are driving the decrease in LRR. LRR does still occur, however. LRR reflects biology of the cancer, as does systemic recurrence. LRR of breast cancer is frequently associated with systemic disease recurrence and poor prognosis. Given this associated poor prognosis, historically, it has been unclear whether patients with LRR would benefit from aggressive therapy with curative intent. Findings in retrospective studies suggest that prognosis for patients with LRR is not universally poor, and some patients may benefit from aggressive locoregional and systemic therapy. The challenge remains to assess prognosis and appropriately treat patients with locoregional breast cancer recurrence.
authors.affiliation: Division of Hematology/Oncology, Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.
authors.forename: Arati Rani
authors.initials: AR
authors.lastname: Chand
authors.affiliation: Department of Surgery, Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA.
authors.forename: M Firdos
authors.initials: MF
authors.lastname: Ziauddin
authors.affiliation: Division of Hematology/Oncology, Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA; Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China. Electronic address: stang@augusta.edu.
authors.forename: Shou-Ching
authors.initials: SC
authors.lastname: Tang
mesh_terms: D001943:Breast Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D011379:Prognosis
keywords: Locoregional recurrence; Prognosis; Radiation; Surgery; Systemic therapy