title: Tooth loss in generalized aggressive periodontitis: Prognostic factors after 17 years of supportive periodontal treatment.
abstract: OBJECTIVE
  This retrospective longitudinal study assessed the risk of and prognostic factors for tooth loss in patients with generalized aggressive periodontitis (GAgP) after periodontal treatment in a university setting.
  
  
  METHODS
  Fifty-seven patients (1,505 teeth) were examined before (T0) and after active periodontal therapy (APT, T1) as well as after 17.4 ± 4.8 [range: 9-28] years of supportive periodontal therapy (SPT, T2). Descriptive statistics and a Cox-proportional-hazards shared-frailty model were applied.
  
  
  RESULTS
  Overall, 98 and 134 teeth were lost during APT and SPT, respectively, with 0.14 ± 0.18 teeth being lost per patient and year. During SPT, three patients (5%) lost ≥10 teeth, 14 (25%) lost 4-9 teeth, 40 lost 0-3 (70%) teeth, respectively. One-third (n = 19) of all patients lost no teeth. Mean PPD of the teeth surviving SPT was stable from T1 (3.5 ± 1.1 mm) to T2 (3.4 ± 1.1 mm). Nearly, 84% of all survived teeth showed stable or improved bone level at T2. Risk of tooth loss was significantly increased in active smokers (HR[95% CI]: 4.94[1.91/12.75]), the upper dental arch (1.94[1,16/3.25]), with each mm of residual PPD (1.41[1.29/1.53]), teeth with furcation involvement (FI) (HR 4.00-4.44 for different degrees) and mobility (5.39 [2.06/14.1] for degree III).
  
  
  CONCLUSIONS
  Within the provided conservative treatment regimen, GAgP patients lost only few teeth.
authors.affiliation: Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany.
authors.forename: Christian
authors.identifier: http://orcid.org/0000-0002-8316-0565
authors.initials: C
authors.lastname: Graetz
authors.affiliation: Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany.
authors.forename: Sonja
authors.identifier: http://orcid.org/0000-0002-9099-7750
authors.initials: S
authors.lastname: Sälzer
authors.affiliation: Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Plaumann
authors.affiliation: Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, Jena, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Schlattmann
authors.affiliation: Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany.
authors.forename: Maren
authors.initials: M
authors.lastname: Kahl
authors.affiliation: Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Springer
authors.affiliation: Clinic of Conservative Dentistry and Periodontology, University of Kiel, Kiel, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Dörfer
authors.affiliation: Department of Operative and Preventive Dentistry, Charité University of Berlin, Berlin, Germany.
authors.forename: Falk
authors.identifier: http://orcid.org/0000-0003-1223-1669
authors.initials: F
authors.lastname: Schwendicke
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000150:complications* / Q000628:therapy*; D016301:Alveolar Bone Loss / Q000150:complications / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000150:complications / Q000628:therapy; D005858:Germany; D006801:Humans; D007180:Incisor; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008963:Molar; D010514:Periodontal Pocket / Q000150:complications / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016388:Tooth Loss / Q000209:etiology*; D014086:Tooth Mobility / Q000145:classification / Q000150:complications / Q000628:therapy; D016896:Treatment Outcome; D055815:Young Adult
keywords: aggressive periodontitis; maintenance; periodontal therapy; risk model; tooth loss