title: BODIPY blocked anthroxyl radicals: the substituent effect on reactivity and fluorescence turn-on detection of a hydroxyl radical.
abstract: Two BODIPY-substituted anthroxyl radicals were investigated. The one with two ethyl substituents (2Et-BO-An-O) is sensitive to air and silica gel due to the lack of sufficient kinetic blocking, while another one with four methyl substituents (4Me-BO-An-O) shows high stability. The structure of the latter was fully characterized by X-ray crystallographic analysis and electron-spin resonance spectra. 4Me-BO-An-O was subjected to react with various reactive oxygen/nitrogen species (ROS/RNS) and selective fluorescence turn-on detection of a hydroxyl radical was achieved, validating the concept of "using stable radicals to detect ROS/RNS".
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. chmwuj@nus.edu.sg.
authors.forename: Fang
authors.initials: F
authors.lastname: Miao
authors.forename: Zheng Long
authors.initials: ZL
authors.lastname: Lim
authors.forename: Pan
authors.initials: P
authors.lastname: Hu
authors.forename: Shaoqiang
authors.initials: S
authors.lastname: Dong
authors.forename: Qingbiao
authors.initials: Q
authors.lastname: Qi
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Zhang
authors.forename: Jishan
authors.initials: J
authors.lastname: Wu