title: Thermosensitive hydrogel loaded with chitosan-carbon nanotubes for near infrared light triggered drug delivery.
abstract: Controlled drug release with on demand is an important challenge for drug delivery. Near-infrared (NIR) light triggered drug delivery reflected the development of a significant strategy to control drug release based on photothermal effects. Herein, a sustained and controlled drug delivery system was developed based on a PCL-PEG-PCL thermosensitive hydrogel combined with chitosan-multiwalled carbon nanotubes for a near infrared light triggered drug delivery. Carbon nanotubes that incorporate hydrogel can enhance the sustained effect of drug delivery by a dual-stage release and allow drug delivery by controlling light irradiation. This in situ photothermal process was monitored by thermal imaging and the controlled drug delivery of doxorubicin was tracked in real-time by fluorescence imaging in vivo based on the fluorescence ability of the drug using nude mice as models. The results suggest that the photothermal effect of the carbon nanotubes can disrupt the structure of the hydrogel with a gel-sol transition, triggering the release of the drug from the sustained drug delivery system by NIR irradiation while responding on demand. The sustained and controlled drug delivery has the potential to implement the accurate administration of hydrogel-based drug delivery systems.
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Dong
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Chang
authors.initials: C
authors.lastname: Wei
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liang
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Tianjun
authors.initials: T
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China.
authors.forename: Deling
authors.initials: D
authors.lastname: Kong
authors.affiliation: Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, PR China. Electronic address: lvfeng2002@163.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Lv
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000378:metabolism; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism; D004339:Drug Compounding; D065546:Drug Liberation; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D020100:Hydrogels / Q000737:chemistry*; D007259:Infrared Rays; D007700:Kinetics; D051379:Mice; D008819:Mice, Nude; D037742:Nanotubes, Carbon / Q000737:chemistry*; D044367:Phase Transition / Q000528:radiation effects*; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013696:Temperature
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D020100:Hydrogels; D037742:Nanotubes, Carbon; D011091:Polyesters; C515340:poly(epsilon-caprolactone)-b-poly(ethyleneglycol)-b-poly(epsilon-caprolactone); D011092:Polyethylene Glycols; D004317:Doxorubicin; D048271:Chitosan
keywords: Carbon nanotube; Controlled release; Imaging tracking; NIR light triggered; Thermosensitive hydrogel