title: Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi.
abstract: Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets.
  
  
  
  In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes.
  
  
  
  Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system.
authors.affiliation: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, HsinChu, Taiwan.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Liu
authors.affiliation: Department of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan.
authors.forename: Wen Liang
authors.initials: WL
authors.lastname: Chen
authors.affiliation: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, HsinChu, Taiwan.
authors.forename: Wei-Hsiang
authors.initials: WH
authors.lastname: Kung
authors.affiliation: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, HsinChu, Taiwan. bryan@mail.nctu.edu.tw.|Department of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan. bryan@mail.nctu.edu.tw.|Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, 300, Taiwan. bryan@mail.nctu.edu.tw.|Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, 300, Taiwan. bryan@mail.nctu.edu.tw.
authors.forename: Hsien-Da
authors.initials: HD
authors.lastname: Huang
mesh_terms: D030541:Databases, Genetic; D004032:Diet; D006801:Humans; D053613:Janus Kinase 1 / Q000097:blood / Q000235:genetics; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics; D064209:Phytochemicals / Q000097:blood*; D010944:Plants / Q000737:chemistry* / Q000235:genetics; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000097:blood* / Q000235:genetics; D050791:STAT Transcription Factors / Q000097:blood / Q000235:genetics; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D064209:Phytochemicals; D034741:RNA, Small Interfering; D050791:STAT Transcription Factors; D053613:Janus Kinase 1
keywords: Circulating miRNAs; Cross Kingdom RNAi; Plant miRNAs; miR2910