title: Surveillance of Severe Acute Respiratory Infection (SARI) for Hospitalized Patients in Northern Vietnam, 2011-2014.
abstract: Severe acute respiratory infections (SARI) are leading causes of hospitalization, morbidity, and mortality in children worldwide. The aim of this study was to identify viral pathogens responsible for SARI in northern Vietnam in the period from 2011 to 2014. Throat swabs and tracheal aspirates were collected from SARI patients according to WHO guidelines. The presence of 13 different viral pathogens (influenza A[H1N1]pdm09; A/H3N2; A/H5; A/H7 and B; para influenza 1,2,3; RSV; HMPV; adeno; severe acute respiratory syndrome-CoV and rhino) was tested by conventional/real-time reverse transcription-polymerase chain reaction. During the study period, 975 samples were collected and tested. More than 30% (32.1%, 313 samples) of the samples showed evidence of infection with influenza viruses, including A/H3N2 (48 samples), A (H1N1) pdm09 (221 samples), influenza B (42 samples), and co-infection of A (H1N1) pdm09 or A/H3N2 and influenza B (2 samples). Other respiratory pathogens were detected in 101 samples, including rhinovirus (73 samples), adenovirus (10 samples), hMPV (9 samples), parainfluenza 3 (5 samples), parainfluenza 2 (3 samples), and RSV (1 sample). Influenza A/H5, A/H7, or SARS-CoV were not detected. Respiratory viral infection, particularly infection of influenza and rhinoviruses, were associated with high rates of SARI hospitalization, and future studies correlating the clinical aspects are needed to design interventions, including targeted vaccination.
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Hang Khanh Le
authors.initials: HKL
authors.lastname: Nguyen
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Son Vu
authors.initials: SV
authors.lastname: Nguyen
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Anh Phuong
authors.initials: AP
authors.lastname: Nguyen
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Phuong Mai Vu
authors.initials: PMV
authors.lastname: Hoang
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Thanh Thi
authors.initials: TT
authors.lastname: Le
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Thach Co
authors.initials: TC
authors.lastname: Nguyen
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Huong Thu
authors.initials: HT
authors.lastname: Hoang
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Cuong Duc
authors.initials: CD
authors.lastname: Vuong
authors.affiliation: National Traditional Medicine Hospital.
authors.forename: Loan Thi Thanh
authors.initials: LTT
authors.lastname: Tran
authors.affiliation: Virology Department, National Institute of Hygiene and Epidemiology.
authors.forename: Mai Quynh
authors.initials: MQ
authors.lastname: Le
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D062665:Epidemiological Monitoring; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010614:Pharynx / Q000821:virology; D015995:Prevalence; D060888:Real-Time Polymerase Chain Reaction; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000821:virology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014132:Trachea / Q000821:virology; D014744:Vietnam / Q000453:epidemiology; D014777:Virus Diseases / Q000453:epidemiology* / Q000821:virology*; D014780:Viruses / Q000145:classification* / Q000302:isolation & purification*; D055815:Young Adult
keywords: hospitalized patients; northern Vietnam; respiratory viruses; severe acute respiratory infection (SARI)