title: Treatment of recurrent aphthous stomatitis with Er,Cr:YSGG laser irradiation: A randomized controlled split mouth clinical study.
abstract: The present randomized controlled split mouth clinical study aimed to investigate the efficacy of Er,Cr:YSGG laser irradiation on pain reduction and healing rate of recurrent aphthous stomatitis. 40 patients with RAS were recruited for this study and RAS ulcerations of each patient were randomly assigned to the control or test group. In the test group, Er,Cr:YSGG laser with non-contact mode was used to irradiate RAS lesions. In the placebo group, RAS lesions were irradiated with the same device without laser emission. Pain was evaluated with visual analog scale (VAS) while a clinician graded healing of RAS (HRAS). In the placebo group at immediate; scores of VAS presented no statistically significance; in the test group, laser application showed significant pain reducing, at 1st day control. In the test group, a significantly healing effect at 1st day control was observed and this effect was maintained throughout the study. In the placebo group, scores of HRAS were statistically significant at controls on 3, 7, 10days. Statistically significant difference between the scores of VAS and HRAS was found for all control days except day 10 according to the intergroup comparisons. Based on these findings, Er,Cr:YSGG laser application at 0.25W without water may be appropriate to reduce pain and also accelerate the healing of RAS.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Near East University, Mersin, Turkey. Electronic address: guneyyilmaz@hotmail.com.
authors.forename: Hasan Guney
authors.initials: HG
authors.lastname: Yilmaz
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Near East University, Mersin, Turkey.
authors.forename: Mohammed Rateb
authors.initials: MR
authors.lastname: Albaba
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Near East University, Mersin, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Caygur
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, Mersin University, Mersin, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Cengiz
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Boke-Karacaoglu
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Near East University, Mersin, Turkey.
authors.forename: Hayriye
authors.initials: H
authors.lastname: Tumer
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000528:radiation effects; D013281:Stomatitis, Aphthous / Q000532:radiotherapy*; D016896:Treatment Outcome; D014945:Wound Healing / Q000528:radiation effects; D055815:Young Adult
keywords: Aphtous ulceration; Er,Cr:YSGG laser; Stomatitis