title: Growth throughout childhood of children born growth restricted.
abstract: Many studies that examine growth in growth-restricted children at birth do not discriminate between fetal growth restriction (FGR) and small for gestational age (SGA). These terms however are not synonymous. In SGA, stunting and increased weight gain have been reported. We do not know if this holds true for FGR. Our aim was to study postnatal growth until age 12.5 years in a cohort of children born FGR due to early onset placental insufficiency, and its relation to FGR severity.
  
  
  
  Prospective cohort study, follow-up of an antenatal randomised controlled trial in two tertiary centres.
  
  
  
  Children aged 12.5 years born after FGR, with mothers who had severe early onset hypertensive pregnancy disorders (N=96).
  
  
  
  Anthropometry at age 12.5 years in SD scores (SDS).
  
  
  
  Mean height SDS (SD) corrected for target height was -0.09 (0.94), mean body mass index (BMI) SDS was 0.00 (1.16) and mean head circumference SDS was -0.37 (1.11). Catch-up growth was at fastest rate between term age and 3 months and similar for height (0.55 SDS/months) and weight (0.49 SDS/months). Neither FGR severity nor gestational age was related to height and BMI at age 12.5 years.
  
  
  
  Children born growth restricted due to early onset placental insufficiency have height and BMI scores comparable to their age-matched peers at age 12.5 years. FGR severity was not related to height and BMI at age 12.5 years. These reassuring results differ from most studies that examine SGA children.
authors.affiliation: Department of Paediatrics, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Fenny
authors.initials: F
authors.lastname: Beukers
authors.affiliation: Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: Rotteveel
authors.affiliation: Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Mirjam M
authors.initials: MM
authors.lastname: van Weissenbruch
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Wessel
authors.initials: W
authors.lastname: Ganzevoort
authors.affiliation: Department of Paediatrics, Academic Medical Center, Amsterdam, The Netherlands.|Department of Paediatrics, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Johannes B
authors.initials: JB
authors.lastname: van Goudoever
authors.affiliation: Department of Paediatrics, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Aleid G
authors.initials: AG
authors.lastname: van Wassenaer-Leemhuis
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D005500:Follow-Up Studies; D006128:Growth / Q000502:physiology*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000503:physiopathology; D009426:Netherlands; D010927:Placental Insufficiency / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology; D012016:Reference Values
keywords: Child growth; Fetal growth restriction; General Paediatrics; Neonatology; Placental insufficiency