title: Temporary resolution of insulin requirement in acquired partial lipodystrophy associated with chronic graft-versus-host disease.
abstract: This is a case presentation describing a high insulin requirement that suddenly resolved in a patient with acute lymphoblastic leukemia treated with stem cell transplantation complicated by chronic graft-versus-host disease. The patient was diagnosed with acquired partial lipodystrophy that did not require alternative therapies such as leptin or insulin-like growth factor 1.
authors.affiliation: Department of Pediatric Endocrinology, UCLA Mattel Children's Hospital, Los Angeles, California.
authors.forename: Leslie
authors.initials: L
authors.lastname: Kimura
authors.affiliation: Department of Pediatric Endocrinology, Children's Hospital of Los Angeles, Los Angeles, California.
authors.forename: Griselda
authors.initials: G
authors.lastname: Alvarez
authors.affiliation: Department of Biomathematics, UCLA David Geffen School of Medicine, Los Angeles, California.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Pediatric Endocrinology, UCLA Mattel Children's Hospital, Los Angeles, California.
authors.forename: Anna
authors.initials: A
authors.lastname: Pawlikowska-Haddal
authors.affiliation: Department of Pediatric Hematology-Oncology, UCLA Mattel Children's Hospital, Los Angeles, California.
authors.forename: Theodore B
authors.initials: TB
authors.lastname: Moore
authors.affiliation: Department of Pediatric Hematology-Oncology, UCLA Mattel Children's Hospital, Los Angeles, California.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Casillas
authors.affiliation: Florida Hospital, Orlando, Florida.
authors.forename: Kuk-Wha
authors.initials: KW
authors.lastname: Lee
mesh_terms: D002648:Child; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008060:Lipodystrophy / Q000188:drug therapy / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
keywords: acute lymphoblastic lymphoma (ALL); hypertriglyceridemia; stem cell transplant