title: Recent Advances in Oncological Submissions of Dendrimer.
abstract: Disseminated metastatic cancer requires insistent management owing to its reduced responsiveness for chemotherapeutic agents, toxicity to normal cells consequently lower survival rate and hampered quality of life of patients.
  
  
  
  Dendrimer mediated cancer therapy is advantageous over conventional chemotherapy, radiotherapy and surgical resection due to reduced systemic toxicity, and molecular level cell injury to cancerous mass, for an appreciable survival of the subject. Recently used dendrimer mediated nanotechnology for oncology aims to conquer these challenges. Dendrimers based nano-constructs are having architectures comparable to that of biological vesicles present in the human body.
  
  
  
  Operating with dendrimer technology, proffers the exclusive and novel strategies with numerous applications in cancer management involving diagnostics, therapeutics, imaging, and prognostics by sub-molecular interactions. Dendrimers are designed to acquire the benefits of the malignant tumor morphology and characteristics, i.e. leaky vasculature of tumor, expression of specific cell surface antigen, and rapid proliferation.
  
  
  
  Dendrimers mediated targeted therapy recommends innovatory function equally in diagnostics (imaging, immune-detection) as well as chemotherapy. Currently, dendrimers as nanomedicine has offered a strong assurance and advancement in drastically varying approaches towards cancer imaging and treatment. The present review discusses different approaches for cancer diagnosis and treatment such as, targeted and control therapy, photodynamic therapy, photo-thermal therapy, gene therapy, antiangiogenics therapy, radiotherapy etc.
authors.affiliation: Faculty of Health Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences (Deemed University) Allahabad, UP. India.
authors.forename: Namrata
authors.initials: N
authors.lastname: Soni
authors.affiliation: TIT College of Pharmacy, Technocrats Institute of Technology Campus, Anand Nagar, Raisen Road, Bhopal, MP- 462021. India.
authors.forename: Muktika
authors.initials: M
authors.lastname: Tekade
authors.affiliation: School of Pharmacy, Department of Pharmaceutical Technology, International Medical University, Jalan Jalil Perkasa 19, 57000 Kuala Lumpur. Malaysia.
authors.forename: Prashant
authors.initials: P
authors.lastname: Kesharwani
authors.affiliation: National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Opposite Air Force Station Palaj, Gandhinagar, Gujarat-382355. India.
authors.forename: Pallab
authors.initials: P
authors.lastname: Bhattacharya
authors.affiliation: Department of Pharmaceutics, BM College of Pharmaceutical Education & Research, Indore, MP-452020. India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Maheshwari
authors.affiliation: Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Ultimo New South Wales 2007. Australia.
authors.forename: Kamal
authors.initials: K
authors.lastname: Dua
authors.affiliation: Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW 2305. Australia.
authors.forename: Philp M
authors.initials: PM
authors.lastname: Hansbro
authors.affiliation: National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Palaj, Opposite Air Force Station, Gandhinagar, Gujarat-382355. India.
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Tekade
mesh_terms: D050091:Dendrimers / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D050091:Dendrimers
keywords: Dendrimers; cancer diagnosis; cancer therapy; malignant tumor morphology; oncology; surgical resection.