title: Discover cervical disc arthroplasty versus anterior cervical discectomy and fusion in symptomatic cervical disc diseases: A meta-analysis.
abstract: OBJECTIVE
  Symptomatic cervical disc disease (SCDD) is a common degenerative disease, and Discover artificial cervical disc, a new-generation nonconstrained artificial disk, has been developed and performed gradually to treat it. We performed this meta-analysis to compare the efficacy and safety between Discover cervical disc arthroplasty (DCDA) and anterior cervical discectomy and fusion (ACDF) for SCDD.
  
  
  METHODS
  An exhaustive literature search of PubMed, EMBASE, and the Cochrane Library was conducted to identify randomized controlled trials that compared DCDA with ACDF for patients suffering SCDD. A random-effect model was used. Results were reported as standardized mean difference or risk ratio with 95% confidence interval.
  
  
  RESULTS
  Of 33 articles identified, six studies were included. Compared with ACDF, DCDA demonstrated shorter operation time (P < 0.0001), and better range of motion (ROM) at the operative level (P < 0.00001). But no significant differences were observed in blood loss, neck disability index (NDI) scores, neck and arm pain scores, Japanese orthopaedic association (JOA) scores, secondary surgery procedures and adverse events (P > 0.05). Subgroup analyses did not demonstrated significant differences.
  
  
  CONCLUSIONS
  In conclusion, DCDA presented shorter operation time, and better ROM at the operative level. However, no significant differences were observed in blood loss, NDI scores, neck and arm pain scores, JOA scores, secondary surgery procedures and adverse events between the two groups. Additionally, more studies of high quality with mid- to long-term follow-up are required in future.
authors.affiliation: Department of Orthopaedics, Xinqiao Hospital, The Third Military Medical University, Shapingba District, Chongqing, China.|Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shangguan
authors.affiliation: Department of Orthopaedics, Xinqiao Hospital, The Third Military Medical University, Shapingba District, Chongqing, China.|Department of Orthopaedics, Tianjin Medical University General Hospital, Heping District, Tianjin, China.
authors.forename: Guang-Zhi
authors.initials: GZ
authors.lastname: Ning
authors.affiliation: Department of Orthopaedics, Xinqiao Hospital, The Third Military Medical University, Shapingba District, Chongqing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
authors.forename: Zhuo-Jing
authors.initials: ZJ
authors.lastname: Luo
authors.affiliation: Department of Orthopaedics, Xinqiao Hospital, The Third Military Medical University, Shapingba District, Chongqing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000328:Adult; D002574:Cervical Vertebrae / Q000601:surgery; D017586:Diskectomy; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000601:surgery; D055959:Intervertebral Disc Degeneration / Q000601:surgery*; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D016059:Range of Motion, Articular; D016896:Treatment Outcome