title: Oral administration of nasturtium affects peptide YY secretion in male subjects.
abstract: Nasturtium plants contain the glucosinolate glucotropaeolin and its corresponding breakdown product benzyl isothiocyanate (BITC), the latter being intensively studied with regard to cancer chemoprevention and anti-inflammatory properties. In addition, recent research has shown that isothiocyanates are able to activate the release of several gut hormones in vitro and in rodent studies. Here, we tested the effects of a dietary nasturtium administration on circulating levels of gut hormones in humans.
  
  
  
  Metabolically healthy males (n = 15) received a single oral dose of 10 g freeze-dried nasturtium leaf material suspended in water or only water (control). Blood samples were taken every hour and serum concentrations of insulin, C-peptide, glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), and peptide (PYY) were analyzed. Oral nasturtium intake resulted in an increased release of PYY over a time period of 6 h whereas circulating levels of other hormones were not changed.
  
  
  
  Given the finding that nasturtium consumption enhances secretion of PYY, a key hormone involved in energy regulation, special diets containing nasturtium, or supplementation with nasturtium or BITC might be considered in the treatment of obesity.
authors.affiliation: German Institute of Human Nutrition Potsdam-Rehbrücke, Department of Clinical Nutrition, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.
authors.forename: Sonja
authors.initials: S
authors.lastname: Schiess
authors.affiliation: University of Hamburg, HAMBURG SCHOOL OF FOOD SCIENCE, Institute of Food Chemistry, Grindelallee 117, D-20146 Hamburg, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Platz
authors.affiliation: German Institute of Human Nutrition Potsdam-Rehbrücke, Department of Clinical Nutrition, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.|Charité University Medicine, Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Hindenburgdamm 30, D-12203 Berlin Berlin, Germany.|German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany.
authors.forename: Margrit
authors.initials: M
authors.lastname: Kemper
authors.affiliation: Leibniz Institute of Vegetable and Ornamental Crops, Großbeeren/Erfurt e.V., Department Plant Quality, Theodor-Echtermeyer-Weg 1, D-14979 Großbeeren, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Schreiner
authors.affiliation: Leibniz Institute of Vegetable and Ornamental Crops, Großbeeren/Erfurt e.V., Department Plant Quality, Theodor-Echtermeyer-Weg 1, D-14979 Großbeeren, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Mewis
authors.affiliation: University of Hamburg, HAMBURG SCHOOL OF FOOD SCIENCE, Institute of Food Chemistry, Grindelallee 117, D-20146 Hamburg, Germany.
authors.forename: Sascha
authors.initials: S
authors.lastname: Rohn
authors.affiliation: Leibniz Institute of Vegetable and Ornamental Crops, Großbeeren/Erfurt e.V., Department Plant Quality, Theodor-Echtermeyer-Weg 1, D-14979 Großbeeren, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Bumke-Vogt
authors.affiliation: German Institute of Human Nutrition Potsdam-Rehbrücke, Department of Clinical Nutrition, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.|Charité University Medicine, Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Hindenburgdamm 30, D-12203 Berlin Berlin, Germany.|German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany.
authors.forename: Olga
authors.initials: O
authors.lastname: Pivovarova
authors.affiliation: German Institute of Human Nutrition Potsdam-Rehbrücke, Department of Clinical Nutrition, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.|Charité University Medicine, Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Hindenburgdamm 30, D-12203 Berlin Berlin, Germany.|German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany.
authors.forename: Andreas F H
authors.initials: AFH
authors.lastname: Pfeiffer
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D019587:Dietary Supplements; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D014644:Genetic Variation; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D031223:Nasturtium; D019894:Peptide YY / Q000097:blood*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D000098706:Taste Receptors, Type 2
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D043562:Receptors, G-Protein-Coupled; D000098706:Taste Receptors, Type 2; D019894:Peptide YY; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1
keywords: Benzyl isothiocyanate; Brassicaceous vegetables; Gut hormones; Human intervention study; PYY