title: Pteropine orthoreovirus: An important emerging virus causing infectious disease in the tropics?
abstract: BACKGROUND
  Pteropine orthoreovirus (PRV) is an emerging zoonotic respiratory virus that has spilled over from bats to humans. Though initially found only in bats, further case studies have found viable virus in ill patients.
  
  
  METHODS
  PubMed was queried with the keywords of Nelson Bay orthoreovirus OR Pteropine orthoreovirus OR Melaka orthoreovirus OR Kampar orthoreovirus, and returned 17 hits.
  
  
  RESULTS
  Based on prevalence studies, the presence of PRV has been reported in Malaysia and Vietnam, both developing countries. Other case reports also provide further evidence of the presence of PRV in the Southeast Asian region. Despite the absence of PRV in their home countries, travellers from Hong Kong and Japan to Indonesia have returned to their countries ill with this virus, indicating that local communities in Indonesia might be affected by this virus.
  
  
  CONCLUSIONS
  This work aims to bring to light this emerging zoonotic respiratory virus circulating among developing countries in Southeast Asia. To improve the understanding of PRV of the medical and scientific community in the Southeast Asian region, this work introduces the general features of PRV, reports of imported PRV, prevalence, and clinical features of PRV. Gaps in knowledge about PRV have also been identified in this work, and we hope that future studies can be undertaken to improve our understanding of this virus.
authors.affiliation: International Medical University, Kuala Lumpur, Malaysia. yehfongtan@gmail.com.
authors.forename: Yeh Fong
authors.initials: YF
authors.lastname: Tan
authors.forename: Cheong Lieng
authors.initials: CL
authors.lastname: Teng
authors.forename: Kaw Bing
authors.initials: KB
authors.lastname: Chua
authors.forename: Kenny
authors.initials: K
authors.lastname: Voon
mesh_terms: D000818:Animals; D001210:Asia, Southeastern / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D006801:Humans; D018165:Orthoreovirus / Q000302:isolation & purification*; D015995:Prevalence; D012088:Reoviridae Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D014329:Tropical Climate; D015047:Zoonoses / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*