title: Biologic Therapy in Chronic Obstructive Pulmonary Disease.
abstract: Chronic obstructive pulmonary disease (COPD) is common worldwide. The predominant cause in most COPD is environmental exposure to toxicants. The inflammatory processes in COPD are multifactorial, complex, and interacting, leading to many potential therapeutic targets. Although most typically associated with neutrophilic/macrophagic inflammation (type 1), it is now known that COPD can also be associated with eosinophilic inflammation (type 2), particularly in exacerbations. Accordingly, there is an active program of investigation of highly selective biologic therapeutic agents in the management of COPD. This review summarizes clinical trials of the use of these novel agents in the management of COPD.
authors.affiliation: Division of Allergy and Clinical Immunology, University of Texas Medical Branch, 4.116 JSA, 301 University Boulevard, Galveston, TX 77555-0568, USA.
authors.forename: Julia W
authors.initials: JW
authors.lastname: Tripple
authors.affiliation: Division of Allergy and Clinical Immunology, University of Texas Medical Branch, 4.116 JSA, 301 University Boulevard, Galveston, TX 77555-0568, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: McCracken
authors.affiliation: Division of Allergy and Clinical Immunology, University of Texas Medical Branch, 4.116 JSA, 301 University Boulevard, Galveston, TX 77555-0568, USA. Electronic address: william.calhoun@utmb.edu.
authors.forename: William J
authors.initials: WJ
authors.lastname: Calhoun
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D001691:Biological Therapy / Q000379:methods; D004804:Eosinophils / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D058990:Molecular Targeted Therapy; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D001688:Biological Products
keywords: Biologic therapy; COPD; Exacerbation; IL-5; TNF-alpha