title: Influential factors on serum albumin concentration in hospitalized chronic kidney disease patients.
abstract: BACKGROUND
  Serum albumin concentration (SAC) is a prognostic factor that is affected by many factors such as postural change, liver function and food intake. Chronic kidney disease (CKD) patients excrete proteinuria, have low-protein diet, and receive glucocorticoid therapy. No one has evaluated the most influential factors on SAC in CKD patients.
  
  
  METHODS
  A retrospective study. Hospitalized CKD patients with less than 1 g/gCreatinine proteinuria receiving glucocorticoid therapy (n=28), with 1 or more g/gCreatinine proteinuria not receiving glucocorticoid therapy (n=36), and with 1 or more g/gCreatinine proteinuria receiving glucocorticoid therapy (n=39) were enrolled. SAC, hemoglobin, proteinuria and blood pressure at the last outpatient check-up before hospitalization, on the second day of hospitalization, at the last laboratory examination before discharge, as well as at the first outpatient follow-up after discharge were analyzed.
  
  
  RESULTS
  SAC decreased on the second day of hospitalization and increased at the first outpatient follow-up significantly in all groups. Unexpectedly, the change of SAC was irrelevant to the amount of proteinuria.
  
  
  CONCLUSIONS
  SAC was affected by not only proteinuria, but also postural change, physical activity, and food in CKD patients. SAC should be analyzed by standardizing a patient's condition during phlebotomy. J. Med. Invest. 64: 146-152, February, 2017.
authors.affiliation: Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School.
authors.forename: Sakiya
authors.initials: S
authors.lastname: Yoshimoto
authors.forename: Kojiro
authors.initials: K
authors.lastname: Nagai
authors.forename: Eriko
authors.initials: E
authors.lastname: Shibata
authors.forename: Sayo
authors.initials: S
authors.lastname: Ueda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ono
authors.forename: Masanori
authors.initials: M
authors.lastname: Tamaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Nishimura
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Obata
authors.forename: Taizo
authors.initials: T
authors.lastname: Inagaki
authors.forename: Masanori
authors.initials: M
authors.lastname: Minato
authors.forename: Fumi
authors.initials: F
authors.lastname: Kishi
authors.forename: Motokazu
authors.initials: M
authors.lastname: Matsuura
authors.forename: Naoko
authors.initials: N
authors.lastname: Matsui
authors.forename: Itsuro
authors.initials: I
authors.lastname: Endo
authors.forename: Michael
authors.initials: M
authors.lastname: Hann
authors.forename: Seiji
authors.initials: S
authors.lastname: Kishi
authors.forename: Taichi
authors.initials: T
authors.lastname: Murakami
authors.forename: Hideharu
authors.initials: H
authors.lastname: Abe
authors.forename: Toshio
authors.initials: T
authors.lastname: Doi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006454:Hemoglobins / Q000378:metabolism; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology; D011379:Prognosis; D011507:Proteinuria / Q000097:blood / Q000188:drug therapy; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000188:drug therapy; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D006454:Hemoglobins; D012709:Serum Albumin