title: Palladium-catalyzed tandem addition/cyclization in aqueous medium: synthesis of 2-arylindoles.
abstract: An efficient protocol to construct 2-arylindoles was developed through palladium-catalyzed tandem addition/cyclization of potassium aryltrifluoroborates with aliphatic nitriles in aqueous medium. The use of water as the reaction medium makes the synthesis process environmentally benign. A plausible mechanism for the formation of 2-arylindoles involving sequential nucleophilic addition followed by an intramolecular cyclization is proposed. Moreover, the utility of this catalytic tandem transformation was also demonstrated in an efficient gram-scale synthesis. This method provides an alternative synthetic tool for accessing a more diverse array of 2-arylindoles.
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China. jiuxichen@wzu.edu.cn chengtx_wzu@163.com.
authors.forename: Shuling
authors.initials: S
authors.lastname: Yu
authors.forename: Kun
authors.initials: K
authors.lastname: Hu
authors.forename: Julin
authors.initials: J
authors.lastname: Gong
authors.forename: Linjun
authors.initials: L
authors.lastname: Qi
authors.forename: Jianghe
authors.initials: J
authors.lastname: Zhu
authors.forename: Yetong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tianxing
authors.initials: T
authors.lastname: Cheng
authors.forename: Jiuxi
authors.initials: J
authors.lastname: Chen