title: Fluorescent probes sensitive to changes in the cholesterol-to-phospholipids molar ratio in human platelet membranes during atherosclerosis.
abstract: Environment-sensitive fluorescent probes were used for the spectroscopic visualization of pathological changes in human platelet membranes during cerebral atherosclerosis. It has been estimated that the ratiometric probes 2-(2'-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazole and 2-phenyl-phenanthr[9,10]oxazole can detect changes in the cholesterol-to-phospholipids molar ratio in human platelet membranes during the disease.
authors.affiliation: Institute of Chemistry, V.N. Karazin Kharkiv National University, Kharkiv 61022, Ukraine.
authors.forename: Yevgen
authors.initials: Y
authors.lastname: Posokhov
mesh_terms: D050197:Atherosclerosis; D001792:Blood Platelets; D002462:Cell Membrane; D002784:Cholesterol; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008563:Membrane Lipids; D008567:Membranes, Artificial; D010743:Phospholipids; D010974:Platelet Aggregation
chemical_list: D005456:Fluorescent Dyes; D008563:Membrane Lipids; D008567:Membranes, Artificial; D010743:Phospholipids; D002784:Cholesterol