title: A water-soluble pillar[5]arene as a new carrier for an old drug.
abstract: The remarkable affinity of deca-carboxylatopillar[5]arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.
authors.affiliation: Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy. anotti@unime.it ipisagatti@unime.it.
authors.forename: Lucia
authors.initials: L
authors.lastname: Barbera
authors.forename: Domenico
authors.initials: D
authors.lastname: Franco
authors.forename: Laura M
authors.initials: LM
authors.lastname: De Plano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gattuso
authors.forename: Salvatore P P
authors.initials: SP
authors.lastname: Guglielmino
authors.forename: Germana
authors.initials: G
authors.lastname: Lentini
authors.forename: Nadia
authors.initials: N
authors.lastname: Manganaro
authors.forename: Nino
authors.initials: N
authors.lastname: Marino
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Pappalardo
authors.forename: Melchiorre F
authors.initials: MF
authors.lastname: Parisi
authors.forename: Fausto
authors.initials: F
authors.lastname: Puntoriero
authors.forename: Ilenia
authors.initials: I
authors.lastname: Pisagatti
authors.forename: Anna
authors.initials: A
authors.lastname: Notti
mesh_terms: D000583:Amikacin / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D047250:Calixarenes; D004337:Drug Carriers / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D014867:Water / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D000644:Quaternary Ammonium Compounds; C570642:pillar(5)arene; D014867:Water; D047250:Calixarenes; D000583:Amikacin