title: Starch-Derived Nanographene Oxide Paves the Way for Electrospinnable and Bioactive Starch Scaffolds for Bone Tissue Engineering.
abstract: A straightforward process that enabled electrospinning of bioactive starch-based nanofiber scaffolds was developed by utilizing starch derived nano graphene oxide (nGO) as a property enhancer and formic acid as a solvent and esterification reagent. The reaction mechanism and process were followed by detailed spectroscopic investigation. Furthermore, the incorporation of nGO as a "green bioactive additive" endorsed starch nanofibrous scaffolds several advantageous functionalities including improved electrospinnability and thermal stability, good cytocompatibility, osteo-bioactivity, and retained biodegradability. The biodegradable starch/nGO nanofibers underwent simultaneous degradation and mineralization process during 1 week of cell culture and mineralization test, thus, mimicking the structure and function of extracellular matrices (ECMs) and indicating promise for bone tissue engineering applications.
authors.affiliation: Department of Fibre and Polymer Technology, KTH Royal Institute of Technology , SE-100 44 Stockholm, Sweden.
authors.forename: Duo
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Textile Technology, Indian Institute of Technology Delhi , Hauz Khas, New Delhi 110016, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Samanta
authors.affiliation: Department of Textile Technology, Indian Institute of Technology Delhi , Hauz Khas, New Delhi 110016, India.
authors.forename: Rajiv K
authors.initials: RK
authors.lastname: Srivastava
authors.affiliation: Department of Fibre and Polymer Technology, KTH Royal Institute of Technology , SE-100 44 Stockholm, Sweden.
authors.forename: Minna
authors.identifier: http://orcid.org/0000-0002-7790-8987
authors.initials: M
authors.lastname: Hakkarainen
mesh_terms: D001861:Bone Regeneration; D018786:Bone Substitutes / Q000009:adverse effects / Q000737:chemistry*; D045744:Cell Line, Tumor; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*; D010006:Osteoblasts / Q000187:drug effects; D013213:Starch / Q000031:analogs & derivatives*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000009:adverse effects / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D006108:Graphite; D013213:Starch