title: Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi.
abstract: Subtilases belong to a superfamily of serine proteases which are ubiquitous in fungi and are suspected to have developed distinct functional properties to help fungi adapt to different ecological niches. In this study, we conducted a large-scale phylogenomic survey of subtilase protease genes in 83 whole genome sequenced fungal species in order to identify the evolutionary patterns and subsequent functional divergences of different subtilase families among the main lineages of the fungal kingdom. Our comparative genomic analyses of the subtilase superfamily indicated that extensive gene duplications, losses and functional diversifications have occurred in fungi, and that the four families of subtilase enzymes in fungi, including proteinase K-like, Pyrolisin, kexin and S53, have distinct evolutionary histories which may have facilitated the adaptation of fungi to a broad array of life strategies. Our study provides new insights into the evolution of the subtilase superfamily in fungi and expands our understanding of the evolution of fungi with different lifestyles.
authors.affiliation: State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, P.R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gu
authors.affiliation: State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, P.R. China.
authors.forename: Runian
authors.initials: R
authors.lastname: Wu
authors.affiliation: State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, P.R. China.
authors.forename: JinKui
authors.initials: J
authors.lastname: Yang
authors.affiliation: State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, P.R. China.
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
mesh_terms: D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000145:classification / Q000235:genetics*; D005658:Fungi / Q000201:enzymology* / Q000235:genetics; D020440:Gene Duplication; D016681:Genome, Fungal; D010802:Phylogeny; D013381:Subtilisins / Q000145:classification / Q000235:genetics*; D000073336:Whole Genome Sequencing
chemical_list: D005656:Fungal Proteins; D013381:Subtilisins