title: Supplementing intensive targeted computerized cognitive training with social cognitive exercises for people with schizophrenia: An interim report.
abstract: Individuals with schizophrenia demonstrate cognitive, social cognitive, and motivational deficits that contribute to impairment in real-world functioning. In the current study, we investigated the effects of supplementing computerized neurocognitive training with social cognitive exercises, as compared with neurocognitive training alone.
  
  
  
  In this ongoing, double-blind, randomized controlled trial of 111 participants with psychosis, we compare the effects of supplementing intensive targeted cognitive training with social cognitive training exercises (TCT + SCT) with the effects of targeted cognitive training alone (TCT-only). Participants were assessed on cognition, symptoms, functional capacity, and functional outcomes, as well as social cognition and measures related to reward processing.
  
  
  
  Both treatment groups showed significant improvement in multiple cognitive domains and improvement in functional capacity. However, as predicted, TCT + SCT group participants showed significant improvement in prosody identification and reward processing relative to TCT-only participants.
  
  
  
  Our findings indicate that supplementing intensive computerized cognitive training with social cognitive exercises in people with psychosis confers greater benefits in prosody identification and reward processing relative to cognitive training alone, even though both approaches drive significant improvements in cognition and functional capacity. Impairments in both prosody identification and reward processing have been associated with greater negative symptoms and poorer functional outcomes in schizophrenia, raising the possibility that this form of treatment may lead to better long-term outcomes than traditional cognitive training approaches. Follow-up assessments will determine whether results are durable and generalize over time to improvements in symptoms and functioning. (PsycINFO Database Record
authors.affiliation: Department of Psychiatry, University of Minnesota.
authors.forename: Melissa
authors.initials: M
authors.lastname: Fisher
authors.affiliation: Posit Science Inc.
authors.forename: Mor
authors.initials: M
authors.lastname: Nahum
authors.affiliation: Department of Psychiatry, University of California, San Francisco.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Howard
authors.affiliation: Department of Psychiatry, University of California, San Francisco.
authors.forename: Abby
authors.initials: A
authors.lastname: Rowlands
authors.affiliation: Department of Psychiatry, University of California, San Francisco.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brandrett
authors.affiliation: Department of Psychiatry, University of California, San Francisco.
authors.forename: Amy
authors.initials: A
authors.lastname: Kermott
authors.affiliation: Department of Psychiatry, University of California, San Francisco.
authors.forename: Joshua
authors.initials: J
authors.lastname: Woolley
authors.affiliation: Department of Psychiatry, University of Minnesota.
authors.forename: Sophia
authors.initials: S
authors.lastname: Vinogradov
mesh_terms: D000328:Adult; D000072466:Cognitive Remediation / Q000295:instrumentation / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000534:rehabilitation*; D012559:Schizophrenia / Q000534:rehabilitation*; D012938:Social Perception; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome