title: A new fluorescent probe for colorimetric and ratiometric detection of sulfur dioxide derivatives in liver cancer cells.
abstract: A new ratiometric fluorescent probe was constructed with hemicyanine and 7-nitrobenzofurazan for detection of sulfur dioxide derivatives (HSO3-/SO32-). The ratiometric response mode could be attributed to the efficient FRET (Förster resonance energy transfer) platform. The probe exbihited some desirable properties including fast response (within 2 minutes), good selectivity and high sensitivity. Moreover, the probe could detect endogenous HSO3-in liver cancer cells rather than normal liver cells, implying the diagnosal potential of the probe.
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China.
authors.forename: Dong-Peng
authors.initials: DP
authors.lastname: Li
authors.affiliation: Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P.R. China.
authors.forename: Zhao-Yang
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cui
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P.R. China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Miao
authors.affiliation: Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China.
authors.forename: Bao-Xiang
authors.initials: BX
authors.lastname: Zhao
mesh_terms: D001583:Benzoxazoles / Q000737:chemistry; D002232:Carbocyanines / Q000737:chemistry; D003124:Colorimetry; D031541:Fluorescence Resonance Energy Transfer; D005456:Fluorescent Dyes / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology; D008856:Microscopy, Fluorescence; D013458:Sulfur Dioxide / Q000032:analysis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D001583:Benzoxazoles; D002232:Carbocyanines; D005456:Fluorescent Dyes; C000601156:tetramethylene hemicyanine; D014867:Water; D013458:Sulfur Dioxide; C020160:benzofurazan