title: Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health.
abstract: Perfluoroalkyl substances (PFASs) are synthetic chemicals that persist in the environment and in humans. There is a possible association between prenatal PFASs exposure and both neonate adipokines and birth size, yet epidemiological studies are very limited. The objective of this study was to examine associations of prenatal exposure to PFASs with cord blood adipokines and birth size. We conducted birth cohort study, the Hokkaido Study. In this study, 168 mother-child pairs were included. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in maternal blood were determined by liquid chromatography tandem mass spectrometry. Cord blood adiponectin and leptin levels were measured by ELISA and RIA, respectively. Birth weight and ponderal index (PI) were obtained from birth record. The median maternal PFOS and PFOA were 5.1 and 1.4ng/mL, respectively. The median total adiponectin and leptin levels were 19.4μg/mL and 6.2ng/mL, respectively. Adjusted linear regression analyses found that PFOS level was positively associated with total adiponectin levels (β=0.12, 95% CI:0.01, 0.22), contrary was negatively associated with PI (β=-2.25, 95% CI: -4.01, -0.50). PFOA level was negatively associated with birth weight (β=-197, 95% CI: -391, -3). Leptin levels were not associated with PFASs levels. PFOS and adiponectin levels showed marginal dose-response relationship and both PFOS and PFOA and birth size showed significant dose-response relationships. Results from this study suggested that prenatal PFASs exposure may alter cord blood adiponectin levels and may decrease birth size.
authors.affiliation: Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Machiko
authors.initials: M
authors.lastname: Minatoya
authors.affiliation: Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Itoh
authors.affiliation: Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Miyashita
authors.affiliation: Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Araki
authors.affiliation: Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Seiko
authors.initials: S
authors.lastname: Sasaki
authors.affiliation: Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: Ryu
authors.initials: R
authors.lastname: Miura
authors.affiliation: Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan; Division of Respiratory Medicine, Graduate School of Medicine, Sapporo, Japan.
authors.forename: Houman
authors.initials: H
authors.lastname: Goudarzi
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Iwasaki
authors.affiliation: Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan. Electronic address: rkishi@med.hokudai.ac.jp.
authors.forename: Reiko
authors.initials: R
authors.lastname: Kishi
mesh_terms: D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D049628:Body Size / Q000187:drug effects*; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005466:Fluorocarbons / Q000097:blood* / Q000633:toxicity*; D006801:Humans; D007231:Infant, Newborn; D007564:Japan; D020738:Leptin / Q000097:blood; D018811:Maternal Exposure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000453:epidemiology*
chemical_list: C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D004785:Environmental Pollutants; D005466:Fluorocarbons; D020738:Leptin
keywords: Adiponectin; Birth cohort; Leptin; PFOA; PFOS