title: Three new coumarin glycosides from the stems of Hydrangea paniculata.
abstract: Three new coumarin glycosides (1-3), together with three known compounds (4-6), have been obtained from the stems of Hydrangea paniculata Sieb. Their structures were elucidated based on spectroscopic data and chemical evidence. In addition, compounds 1-3 were screened for their neuroprotective effects against serum deprivation-induced PC12 cell damage, hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line, but they were inactive.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Jing-Zhi
authors.initials: JZ
authors.lastname: Yang
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Xiu-Qi
authors.initials: XQ
authors.lastname: Bao
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Nai-Hong
authors.initials: NH
authors.lastname: Chen
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005688:Galactosamine / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031966:Hydrangea / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis; D016716:PC12 Cells; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
chemical_list: C000616978:8-methoxyl umbelliferone 7-O-beta-D-glucopyranosyl (1-6)-O-beta-D-glucopyranoside; D003374:Coumarins; D006027:Glycosides; D008070:Lipopolysaccharides; D018696:Neuroprotective Agents; C000616977:umbelliferone 7-O-beta-D-glucopyranosyl (1-2)-(beta-D-apiofuranosyl (1-6))-beta-D-glucopyranoside; D009569:Nitric Oxide; D005688:Galactosamine
keywords: Hydrangea paniculata; anti-inflammatory; coumarin glycosides; hepatoprotective; neuroprotective