title: Effects of hemoglobin level on the early postsurgical cerebral metabolism in patients with severe traumatic brain injury.
abstract: OBJECTIVE
  The study aims to explore the effects of different levels of haemoglobin (Hb) on early cerebral metabolism in patients with postoperative severe traumatic brain injury (TBI) .
  
  
  METHODS
  Fifty-nine patients were randomly divided into catheter oxygen group and ventilator-assisted respiratory group. Each group was subsequently divided into three subgroups basing on different Hb level: Hb ≤ 70 g/L subgroup, 71 g/L ≤ Hb≤90 g/L subgroup and Hb ≥ 91 g/L subgroup. The blood samples from the femoral artery and the affected side internal jugular vein were, respectively, taken at the same time from the patient after postoperative 3 days.
  
  
  RESULTS
  The incidence of anaemia after severe TBI operation was 88.14%. The VADL and cerebral glucose uptake (CMRglu) in both Hb ≤ 70 g/L and 71 g/L ≤ Hb≤90 g/L patients of oxygen catheter group were less than that in Hb ≥ 91 g/L patients. In the ventilator-assisted breathing group, the VADL and CMRglu of 71 g/L ≤ Hb≤90 g/L patients and Hb ≥ 91 g/L patients were lower than those in Hb ≤ 70 g/L patients. The result from comparing the two 71 g/L ≤ Hb ≤ 90 g/L subgroups showed that the brain metabolic indexs in the ventilator-assisted breathing group were better than those in the catheter oxygen group.
  
  
  CONCLUSIONS
  In severe TBI postoperative patients, Hb≤90 g/L induced decrease in aerobic oxidation in brain tissue. Moreover, for the same Hb level of 71 g/L ≤ Hb≤90 g/L, ventilator-assisted breathing significantly improved cerebral metabolism.
authors.affiliation: a Department of Neurosurgery , Jingjiang People's Hospital , Jingjiang , Jiangsu , China.
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Xia
authors.affiliation: a Department of Neurosurgery , Jingjiang People's Hospital , Jingjiang , Jiangsu , China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Che
authors.affiliation: a Department of Neurosurgery , Jingjiang People's Hospital , Jingjiang , Jiangsu , China.
authors.forename: Jie-Min
authors.initials: JM
authors.lastname: Luo
authors.affiliation: a Department of Neurosurgery , Jingjiang People's Hospital , Jingjiang , Jiangsu , China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhou
authors.affiliation: b Department of ICU , Jingjiang People's Hospital , Jingjiang , Jiangsu , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: b Department of ICU , Jingjiang People's Hospital , Jingjiang , Jiangsu , China.
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Zhang
authors.affiliation: c Department of Neurosurgery , The First People's Hospital Affiliated to Suzhou University , Suzhou , Jiangsu , China.
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology*; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply*; D000070642:Brain Injuries, Traumatic / Q000097:blood* / Q000503:physiopathology* / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011182:Postoperative Care; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D010100:Oxygen
keywords: Traumatic brain injury; cerebral metabolism; haemoglobin