title: Association of the Asp1312Gly Thyroglobulin Gene Polymorphism with Susceptibility to Differentiated Thyroid Cancer in an Iranian Population
abstract: Background and aim: While the causes of thyroid cancer in most patients remain largely unknown, it has recently
  been reported that there may be links to particular chromosome regions. In particular, polymorphisms (SNPs) in the
  thyroglobulin (TG) gene could be susceptibility factors. Methods: In this case-control study, any association of the
  Asp1312Gly single nucleotide polymorphism (SNP) in the TG gene (rs2069556) with susceptibility to differentiated
  thyroid cancer (DTC) was investigated among 103 Iranian patients and 100 controls who had no history of any type of
  cancer. Genomic DNA was extracted from the whole blood by salting out procedure. High Resolution Melting (HRM)
  technique was used to detect this SNP. Results: Data were analyzed with SPSS software and the results showed that
  the recessive GG genotype was associated with an increased risk of differentiated thyroid carcinoma when compared to
  the AA+AG genotypes (OR: 2.06; CI: 1.09-3.89; P-value: 0.025). Conclusion: Although our study demonstrated that
  differentiated thyroid cancer is significantly associated with this polymorphism, further studies with larger populations
  are required to confirm our findings.
authors.affiliation: Department of Genetics, Science and Research branch, Islamic Azad University, Tehran, Iran|Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran. Email: fard-esfahani@pasteur.ac.ir
authors.forename: Maryam
authors.initials: M
authors.lastname: Abidi
authors.forename: Shima
authors.initials: Sh
authors.lastname: Fayaz
authors.forename: Pezhman
authors.initials: P
authors.lastname: Fard Esfahani
keywords: High resolution melting (HRM) analysis; Thyroid carcinoma; single nucleotide polymorphism