title: Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study.
abstract: OBJECTIVE
  Investigate associations of diffuse idiopathic skeletal hyperostosis (DISH) with self-reported and measured physical function in older adults.
  
  
  METHODS
  Cross-sectional analyses of data collected in 1992-96 from a longitudinal cohort.
  
  
  METHODS
  Research clinic within a community.
  
  
  METHODS
  Community-dwelling men (n = 630) and women (n = 961), mean age 71.5 years (SD = 10.8), from the Rancho Bernardo Study.
  
  
  METHODS
  DISH assessed from lateral thoracic and lumbar spine radiographs; self-reported difficulty bending over to the floor, walking 2-3 level blocks, or climbing 1 flight of stairs; performance-based measures of grip strength and chair-stand testing (ability to stand up and sit down in a chair 5 times without using chair arms).
  
  
  RESULTS
  DISH was present in 25.6% of men and 5.5% of women. In age and sex-adjusted models, those with DISH had 1.72-fold increased odds (95% CI: 1.13, 2.62) of self-reported difficulty bending; this remained significant after further adjustment for Cobb angle, weight, stroke, arthritis, and exercise, OR = 1.69, (95% CI: 1.07, 2.66). In fully adjusted multivariate models, those with DISH had worse grip strength, -1.08 kg, P = .01, but did not differ from those without DISH on walking or climbing stairs. In sex-stratified, fully adjusted models, among men only, those with DISH were 2.17-times (95% CI: 1.04, 4.52) more likely to be unable to complete 5 chair stands without using their arms.
  
  
  CONCLUSIONS
  DISH was less prevalent in women but affected almost one-quarter of older white men. People with DISH are more likely to experience physical functional impairment, suggesting that DISH has clinical correlations and is not an incidental radiographic finding.
authors.affiliation: University of California, San Francisco, California.
authors.forename: Wendy B
authors.initials: WB
authors.lastname: Katzman
authors.affiliation: University of California, Los Angeles, California.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Huang
authors.affiliation: University of California, San Diego, California.
authors.forename: Donna
authors.initials: D
authors.lastname: Kritz-Silverstein
authors.affiliation: University of California, San Diego, California.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Barrett-Connor
authors.affiliation: University of California, San Diego, California.
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Kado
mesh_terms: D000367:Age Factors; D000368:Aged; D002140:California / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D018737:Hand Strength; D006801:Humans; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000453:epidemiology*; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D011187:Posture / Q000502:physiology*; D015995:Prevalence; D011859:Radiography; D018570:Risk Assessment; D012737:Sex Factors; D011795:Surveys and Questionnaires; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging; D016138:Walking / Q000502:physiology*
keywords: aging; diffuse idiopathic skeletal hyperostosis (DISH); physical function; sex differences