title: Graphene as multifunctional delivery platform in cancer therapy.
abstract: The biomedical applications of graphene-based nanomaterials including drug and gene delivery have grown rapidly in the past few years. This is due to its high surface area that results in high cargo loading capacity. It is demonstrated that graphene can improve drug efficacy without increasing the dose of the chemotherapeutic agent in cancer treatment. Considering these valuable benefits of graphene, this review focused on the newest advancements in drug and gene delivery systems using graphene and unveiling advantages and disadvantages of different graphene-based materials in introducing an effective cargo delivery system for cancer therapy. Different approaches for reducing cytotoxic impacts of graphene oxide and production of biocompatible delivery platform were also reviewed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2355-2367, 2017.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Nejabat
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Charbgoo
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.|Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ramezani
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D016503:Drug Delivery Systems / Q000009:adverse effects / Q000379:methods*; D018014:Gene Transfer Techniques / Q000009:adverse effects; D015316:Genetic Therapy / Q000379:methods; D006108:Graphite / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D006108:Graphite
keywords: drug delivery; gene delivery; graphene; graphene oxide; targeting