title: Salivary lactoferrin is transferred into the brain via the sublingual route.
abstract: Lactoferrin (LF) is produced by exocrine glands including salivary gland, and has various functions including infection defense. However, the transfer of LF from peripheral organs into the brain remains unclear. To clarify the kinetics of salivary LF (sLF), we investigated the consequences of sialoadenectomy and bovine LF (bLF) sublingual administration in rats. The salivary glands were removed from male Wistar rats, and we measured rat LF levels in the blood and brain at 1 week post-surgery. We also examined the transfer of LF into the organs of the rats after sublingual administration of bLF. Rat LF levels in the blood and brain were significantly reduced by sialoadenectomy. Sublingual bLF administration significantly increased bLF levels in the brain, which then decreased over time. These results indicate that LF is transferred from the sublingual mucosa to the brain, in which favorable effects of sLF on brain will be expected via the sublingual mucosa.
authors.affiliation: a Division of Environmental Pathology, Department of Oral Science , Graduate School of Dentistry, Kanagawa Dental University , Yokosuka , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: b Division of Dental Anatomy, Department of Oral Science , Graduate School of Dentistry, Kanagawa Dental University , Yokosuka , Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: To
authors.affiliation: a Division of Environmental Pathology, Department of Oral Science , Graduate School of Dentistry, Kanagawa Dental University , Yokosuka , Japan.
authors.forename: Juri
authors.initials: J
authors.lastname: Saruta
authors.affiliation: c Department of Highly Advanced Stomatology , Graduate School of Dentistry, Kanagawa Dental University , Yokohama , Japan.
authors.forename: Chikatoshi
authors.initials: C
authors.lastname: Sato
authors.affiliation: d Department of Junior College , School of Dental Hygiene, Kanagawa Dental University , Yokosuka , Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: a Division of Environmental Pathology, Department of Oral Science , Graduate School of Dentistry, Kanagawa Dental University , Yokosuka , Japan.|e Department of Pathology , Tokai University School of Medicine , Isehara , Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kondo
authors.affiliation: c Department of Highly Advanced Stomatology , Graduate School of Dentistry, Kanagawa Dental University , Yokohama , Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shimizu
authors.affiliation: c Department of Highly Advanced Stomatology , Graduate School of Dentistry, Kanagawa Dental University , Yokohama , Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kamata
authors.affiliation: a Division of Environmental Pathology, Department of Oral Science , Graduate School of Dentistry, Kanagawa Dental University , Yokosuka , Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Tsukinoki
mesh_terms: D000286:Administration, Sublingual; D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D007781:Lactoferrin / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism*; D065568:Oral Mucosal Absorption / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000378:metabolism* / Q000601:surgery
chemical_list: D007781:Lactoferrin
keywords: administration; brain; lactoferrin; salivary gland; sublingual