title: Advancing Diagnostics to Address Antibacterial Resistance: The Diagnostics and Devices Committee of the Antibacterial Resistance Leadership Group.
abstract: Diagnostics are a cornerstone of the practice of infectious diseases. However, various limitations frequently lead to unmet clinical needs. In most other domains, diagnostics focus on narrowly defined questions, provide readily interpretable answers, and use true gold standards for development. In contrast, infectious diseases diagnostics must contend with scores of potential pathogens, dozens of clinical syndromes, emerging pathogens, rapid evolution of existing pathogens and their associated resistance mechanisms, and the absence of gold standards in many situations. In spite of these challenges, the importance and value of diagnostics cannot be underestimated. Therefore, the Antibacterial Resistance Leadership Group has identified diagnostics as 1 of 4 major areas of emphasis. Herein, we provide an overview of that development, highlighting several examples where innovation in study design, content, and execution is advancing the field of infectious diseases diagnostics.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, and.|Emergency Medicine Service, Durham Veterans Affairs Medical Center, Durham, North Carolina.
authors.forename: Ephraim L
authors.initials: EL
authors.lastname: Tsalik
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, and.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Petzold
authors.affiliation: Public Health Research Institute Tuberculosis Center, New Jersey Medical School-Rutgers University, Newark.
authors.forename: Barry N
authors.initials: BN
authors.lastname: Kreiswirth
authors.affiliation: Department of Medicine, Case Western Reserve University School of Medicine, and.|Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
authors.affiliation: Division of Pediatric Infectious Diseases, Vanderbilt University, Nashville, Tennessee.
authors.forename: Ritu
authors.initials: R
authors.lastname: Banerjee
authors.affiliation: Department of Medicine, Division of Infectious Diseases, the University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: Ebbing
authors.initials: E
authors.lastname: Lautenbach
authors.affiliation: Center for Biostatistics in AIDS Research and the Department of Biostatistics, Harvard University, Boston, Massachusetts.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Evans
authors.affiliation: Departments of Medicine and Pathology, Divisions of Infectious Diseases and Clinical Microbiology, University of Utah, Salt Lake City.
authors.forename: Kimberly E
authors.initials: KE
authors.lastname: Hanson
authors.affiliation: UCLA David Geffen School of Medicine and Fielding School of Public Health, Los Angeles, California.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Klausner
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
authors.forename: Robin
authors.initials: R
authors.lastname: Patel
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D018070:Biological Specimen Banks; D000068456:Clinical Studies as Topic; D024881:Drug Resistance, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D007753:Laboratories; D007857:Leadership; D025202:Molecular Diagnostic Techniques; D011367:Professional Staff Committees / Q000458:organization & administration; D012107:Research Design; D018805:Sepsis / Q000175:diagnosis / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibacterial resistance; devices.; diagnostics