title: Intrathecal insulin-like growth factor 1 but not insulin enhances myelin repair in young and aged rats.
abstract: One main pathological hallmark of multiple sclerosis (MS) is demyelination. Novel therapies which enhance myelin repair are urgently needed. Insulin and insulin-like growth factor 1 (IGF-1) have strong functional relationships. Here, we addressed the potential capacity of IGF-1 and insulin to enhance remyelination in an animal demyelination model in vivo. We found that chronic intrathecal infusion of IGF-1 enhanced remyelination after lysolecithin-induced demyelination in the spinal cord of young and aged rats. Aged rats showed a weaker innate remyelination capacity and are therefore a good model for progressive MS which is defined by chronic demyelination. In contrast to IGF-1, Insulin had no effect on remyelination in either age group. Our findings highlight the potential use of IGF-1 as remyelinating therapy for MS, particularly the progressive stage in which chronic demyelination is the hallmark.
authors.affiliation: Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland; Cantonal Hospital St.Gallen, Department of Neurosurgery, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Hlavica
authors.affiliation: Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland.
authors.forename: Aro
authors.initials: A
authors.lastname: Delparente
authors.affiliation: Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland.
authors.forename: Andrin
authors.initials: A
authors.lastname: Good
authors.affiliation: Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Good
authors.affiliation: Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland.
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Plattner
authors.affiliation: Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland.
authors.forename: Maryam S
authors.initials: MS
authors.lastname: Seyedsadr
authors.affiliation: Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Schwab
authors.affiliation: VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA.
authors.forename: Dianne P
authors.initials: DP
authors.lastname: Figlewicz
authors.affiliation: Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, ETH Zurich, 8057 Zurich, Switzerland; University Hospital Zurich, Department of Neurology, 8091 Zurich, Switzerland. Electronic address: ineichen@protonmail.ch.
authors.forename: Benjamin V
authors.initials: BV
authors.lastname: Ineichen
mesh_terms: D000818:Animals; D001786:Blood Glucose; D002452:Cell Count; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D007278:Injections, Spinal; D007328:Insulin / Q000008:administration & dosage*; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage*; D008244:Lysophosphatidylcholines; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009186:Myelin Sheath / Q000187:drug effects*; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008244:Lysophosphatidylcholines; D007334:Insulin-Like Growth Factor I
keywords: IGF-1; Insulin; Intrathecal; Lysolecithin; Multiple sclerosis; Rat; Remyelination