title: C3 glomerulopathy.
abstract: C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases caused by abnormal control of complement activation with deposition of complement component C3 in glomeruli leading to variable glomerular inflammation. Before the recognition of the unique pathogenesis of these cases, they were variably classified according to their morphological features. C3 glomerulopathy accounts for roughly 1% of all renal biopsies. Clear definition of this entity has allowed a better understanding of its pathogenesis and clinical course and is likely to lead to the design of rational therapies over the next few years.
authors.affiliation: Department of Medicine, Imperial College London, Hammersmith, London, UK.
authors.forename: H Terence
authors.initials: HT
authors.lastname: Cook
keywords: C3 complement; glomerular inflammation; renal pathology