title: NOTCH1mutation,TP53alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia.
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin.|German Cancer Consortium (DKTK), and German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Hof
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.|Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.|European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
authors.forename: Corinne
authors.initials: C
authors.lastname: Kox
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Groeneveld-Krentz
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.|Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.
authors.forename: Obul R
authors.initials: OR
authors.lastname: Bandapalli
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin.
authors.forename: Leonid
authors.initials: L
authors.lastname: Karawajew
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin.
authors.forename: Katharina
authors.initials: K
authors.lastname: Schedel
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.|Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.
authors.forename: Joachim B
authors.initials: JB
authors.lastname: Kunz
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin.|German Cancer Consortium (DKTK), and German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Eckert
authors.affiliation: HELIOS Medical Clinic Berlin-Buch, Clinic for Hematology, Oncology, Tumor Immunology and Palliative Care, Berlin.
authors.forename: Wolf-Dieter
authors.initials: WD
authors.lastname: Ludwig
authors.affiliation: HELIOS Medical Clinic Berlin-Buch, Clinic for Hematology, Oncology, Tumor Immunology and Palliative Care, Berlin.
authors.forename: Richard
authors.initials: R
authors.lastname: Ratei
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin.
authors.forename: Peter
authors.initials: P
authors.lastname: Rhein
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin.
authors.forename: Günter
authors.initials: G
authors.lastname: Henze
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.|Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.
authors.forename: Martina U
authors.initials: MU
authors.lastname: Muckenthaler
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.|Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.
authors.forename: Andreas E
authors.initials: AE
authors.lastname: Kulozik
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin.
authors.forename: Arend
authors.initials: A
authors.lastname: von Stackelberg
authors.affiliation: Department of Pediatrics, Division of Oncology and Hematology, Charité - University Medical Center Berlin r.kirschner@charite.de.|German Cancer Consortium (DKTK), and German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Renate
authors.initials: R
authors.lastname: Kirschner-Schwabe
mesh_terms: D014408:Biomarkers, Tumor; D002648:Child; D006801:Humans; D016130:Immunophenotyping; D053208:Kaplan-Meier Estimate; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D051881:Receptor, Notch1 / Q000235:genetics* / Q000378:metabolism; D012008:Recurrence; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; C497761:NOTCH1 protein, human; D051881:Receptor, Notch1; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53