title: Successful treatment of recurrentHelicobacter fennelliaebacteraemia by selective digestive decontamination with kanamycin in a lung cancer patient receiving chemotherapy.
abstract: BACKGROUND
  Helicobacter fennelliaeis an enterohepaticHelicobacterspecies causing bacteraemia in immunocompromised hosts. Only a few cases of recurrentH. fennelliaebacteraemia have been reported in Japan and there are no guidelines regarding antimicrobial treatment forH. fennelliaeinfection.
  
  
  METHODS
  H. fennelliaebacteraemia was observed in a patient receiving platinum-based chemotherapy for lung cancer. To prevent recurrence, the patient received antibiotic therapy with cefepime, amoxicillin and doxycycline for 6 weeks, which is similar to the therapy forHelicobactercinaedibacteraemia. Bacteraemia recurred despite the long-term antibiotic therapy. We hypothesized that theH. fennelliaebacteraemia originated from endogenous infection in the intestinal tract due to the long-term damage of the enteric mucosa by platinum-based drugs and performed selective digestive decontamination (SDD) with kanamycin. Bacteraemia did not recur after SDD.
  
  
  CONCLUSIONS
  Our observations indicate that clinicians should be aware of possible recurrentH. fennelliaebacteraemia, which could be effectively prevented by SDD with kanamycin.
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fujiya
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Nagamatsu
authors.affiliation: Department of Microbiology, School of Pharmacy, Aichi Gakuin University , Aichi , Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Tomida
authors.affiliation: Department of Microbiology, School of Pharmacy, Aichi Gakuin University , Aichi , Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kawamura
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Momoko
authors.initials: M
authors.lastname: Mawatari
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kutsuna
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takeshita
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Hayakawa
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Shuzo
authors.initials: S
authors.lastname: Kanagawa
authors.affiliation: Department of Clinical Laboratory, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Mezaki
authors.affiliation: Respiratory Medicine, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Respiratory Medicine, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Ishii
authors.affiliation: Disease Control and Prevention Center, National Center for Global Health and Medicine , Tokyo , Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Ohmagari
keywords: Helicobacter fennelliae; recurrent bacteremia, lung cancer, chemotherapy; selective digestive decontamination, kanamycin