title: Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue.
abstract: Precision medicine approaches, that tailor medications to specific individuals has made paradigm-shifting improvements for patients with certain cancer types.
  
  
  
  Such approaches, however, have not been implemented for patients with diabetic kidney disease. Precision medicine could offer new avenues for novel diagnostic, prognostic and targeted therapeutics development. Genetic studies associated with multiscalar omics datasets from tissue and cell types of interest of well-characterized cohorts are needed to change the current paradigm. In this review, we will discuss precision medicine approaches that the nephrology community can take to analyze tissue samples to develop new therapeutics for patients with diabetic kidney disease.
authors.affiliation: Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd, 415 Clinical Research Building, Philadelphia, PA, 19104, USA.|Division of Nephrology, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
authors.forename: Caroline
authors.initials: C
authors.lastname: Gluck
authors.affiliation: Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd, 415 Clinical Research Building, Philadelphia, PA, 19104, USA.|Department of Genetics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
authors.forename: Yi-An
authors.initials: YA
authors.lastname: Ko
authors.affiliation: Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd, 415 Clinical Research Building, Philadelphia, PA, 19104, USA. ksusztak@mail.med.upenn.edu.|Department of Genetics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. ksusztak@mail.med.upenn.edu.
authors.forename: Katalin
authors.initials: K
authors.lastname: Susztak
mesh_terms: D015415:Biomarkers; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D006801:Humans; D057285:Precision Medicine; D011379:Prognosis
chemical_list: D015415:Biomarkers
keywords: Diabetic kidney disease; Epigenetics; GWAS; Genetic; Genomics; Kidney biopsy; Precision medicine; eQTL