title: Patterns of glaucoma progression in retinal nerve fiber and macular ganglion cell-inner plexiform layer in spectral-domain optical coherence tomography.
abstract: OBJECTIVE
  To evaluate the progressive changes of circumpapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses measured by spectral-domain optical coherence tomography (Cirrus SD-OCT) in open-angle glaucoma.
  
  
  METHODS
  One hundred-fourteen eyes of open-angle glaucoma patients with localized RNFL defect who had 3 years' worth of annual RNFL photography and OCT measurements were enrolled in this retrospective study. The progression rates of serial RNFL and GCIPL thicknesses (µm), angular width (°) and area (mm2) of defect on RNFL and GCIPL deviation maps were determined by linear mixed-effect models.
  
  
  RESULTS
  Over a mean follow-up period of 3.16 years, 50 patients out of a total of 114 patients were classified as progressors based on the structural evaluation. The progressors showed significantly higher progression rates in average, 6 and 11 o'clock sector RNFL thicknesses, angular width and area of defect in RNFL deviation map, as well as inferotemporal and minimum GCIPL thicknesses than the non-progressors. The thicknesses of the 6 o'clock sector RNFL and minimum GCIPL exhibited the highest reduction rates among the RNFL and GCIPL parameters assessed, respectively.
  
  
  CONCLUSIONS
  When evaluating glaucoma progression by OCT, careful observation of the average, 6 and 11 o'clock sectors in RNFL and inferotemporal and minimum GCIPL thicknesses can be helpful. We can effectively assess early changes of glaucoma progression with GCIPL thickness as well as RNFL thickness.
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
authors.forename: Hae Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Jeoung
authors.affiliation: Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University, Seoul, 110-744, Korea.
authors.forename: Byeong Wook
authors.initials: BW
authors.lastname: Yoo
authors.affiliation: Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, 110-744, Korea.
authors.forename: Hee Chan
authors.initials: HC
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea. kihopark@snu.ac.kr.
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D011379:Prognosis; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult
keywords: Cirrus OCT; GCIPL progression; OCT glaucoma progression