title: Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex.
abstract: An addressable single cell imaging strategy combining ToF-SIMS and confocal fluorescence microscopy imaging has been developed, and sucessfully applied to visualize the subcellular distribution of an organoruthenium anticancer complex, [(η6-benzene)Ru(N,N-L)Cl]+(1; L: 4-anilinoquinazoline ligand), showing its accumulation in both cell membrane and nuclei, and verifying its dual-targeting feature.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
authors.forename: Suyan
authors.initials: S
authors.lastname: Liu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn.
authors.forename: Kui
authors.identifier: http://orcid.org/0000-0002-4995-0395
authors.initials: K
authors.lastname: Wu
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn.
authors.forename: Feifei
authors.initials: F
authors.lastname: Jia
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn.
authors.forename: Zhaoying
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Beijing National Laboratory for Molecular Sciences, National Centre for Mass Spectrometry in Beijing, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. fuyi.wang@iccas.ac.cn wukui@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
authors.forename: Fuyi
authors.identifier: http://orcid.org/0000-0003-0962-1260
authors.initials: F
authors.lastname: Wang