title: Expression of Cytokines Interleukin-2, Interleukin-4, Interleukin-10 and Transforming Growth Factor β in Gastric Adenocarcinoma Biopsies Obtained from Mexican Patients
abstract: Objective: In this study, expression of Interleukin-2, Interleukin-4, Interleukin-10 and transforming growth factor
  beta in diffuse and intestinal type gastric cancers from Mexican patients was assessed for use as markers of malignancy.
  Methods: A total of 30 biopsies from gastric adenocarcinomas, 60% diffuse, 20% intestinal and 20% mixed in type, were
  studied by immunohistochemistry. Results: Regarding expression of cytokines, 23% were positive for IL-2, 26.7% for
  IL-4, 16.6% for IL-10 and none for TGF-β. There were found Significant statistically stage differences were noted.For
  example, for stages I-II 100% were IL-2 positive (p = 0.009), 87.5% were IL-4 positive (p = 0.005) and 100.0% IL-10
  positive (p = 0.009). Young women were more likely to suffer gastric adenocarcinoma. In biopsies of male patients
  with gastric cancer, there was an increased expression of IL-2 and in biopsies from female patients in IL4. There was
  significantly greater detection of IL-4 and IL-10 expression in stages I and II than in stages III and IV. It was also found
  that IL-4, IL-10 had a higher positive expression in patients biopsies with low-level differentiations than patients with
  well differentiated gastric cancer in which cases were undetected. Conclusions: These results suggest that positive
  expression of IL-4 and IL-10 may be useful as a molecular marker to distinguish stage I and II diffuse gastric cancers
  which can be more readily controlled.
authors.affiliation: Inmunología Experimental, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico. Email: diazorea@yahoo.com.mx
authors.forename: Maria Alicia
authors.initials: MA
authors.lastname: Diaz Orea
authors.forename: Veronica
authors.initials: V
authors.lastname: Muñoz Perez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gómez Conde
authors.forename: Victor Omar
authors.initials: VO
authors.lastname: Castellanos Sánchez
authors.forename: Rogelio
authors.initials: R
authors.lastname: Gonzalez Lopez
authors.forename: J Carlos
authors.initials: JC
authors.lastname: Flores Alonso
authors.forename: M Elena
authors.initials: ME
authors.lastname: Cárdenas
authors.forename: A Luisa
authors.initials: AL
authors.lastname: Galicia
authors.forename: Aurelio
authors.initials: A
authors.lastname: Mendoza
keywords: Gastric adenocarcinoma; Cytokines; IL2; IL4; IL10; TGFβ