title: Connecting Brain Proteomics with Behavioural Neuroscience in Translational Animal Models of Neuropsychiatric Disorders.
abstract: Modelling psychiatric disorders in animals has been hindered by several challenges related to our poor understanding of the disease causes. This chapter describes recent advances in translational research which may lead to animal models and relevant proteomic biomarkers that can be informative about disease mechanisms and potential new therapeutic targets. The review focuses on the behavioural and molecular correlates in models of schizophrenia and major depressive disorder, as guided by recently established Research Domain Criteria (RDoC). This approach is based on providing proteomic data for aetiologically driven, behaviourally well-characterised animal models to link discovered biomarker candidates with the human disease.
authors.affiliation: Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine, Townsville, QLD, Australia. zoltan.sarnyai@jcu.edu.au.|Discipline of Biomedicine, College of Public Health, Medicine and Veterinary Sciences, James Cook University, Townsville, QLD, Australia. zoltan.sarnyai@jcu.edu.au.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Sarnyai
authors.affiliation: Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D015415:Biomarkers / Q000032:analysis*; D001923:Brain Chemistry; D004195:Disease Models, Animal; D055808:Drug Discovery; D005010:Ethology / Q000379:methods*; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D051379:Mice; D008818:Mice, Neurologic Mutants; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000235:genetics; D009422:Nervous System Diseases / Q000139:chemically induced / Q000235:genetics / Q000523:psychology; D009488:Neurosciences / Q000379:methods*; D011323:Primates; D040901:Proteomics / Q000379:methods*; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity; D057170:Translational Research, Biomedical / Q000379:methods*
chemical_list: D015415:Biomarkers; D009419:Nerve Tissue Proteins; D011619:Psychotropic Drugs
keywords: Animal models; Drug discovery; Proteomics; Psychiatric disease; Research Domain Criteria; Translation