title: Entropy-driven homochiral self-sorting of a dynamic library.
abstract: A dynamic mixture of stereoisomeric macrocycles derived from glutamic acid displayed a homochiral self-selection when increasing the acetonitrile content of the aqueous mixed medium. The homochiral self-sorting required the anionic form of the side chains and increased at higher temperature, implying an entropic origin. Conformational analysis (NMR and MD simulations) allowed us to explain the observed behaviour. The results show that entropy can play a role in the homochiral self-sorting in adaptive bio-inspired chemical systems.
authors.affiliation: Department of Biological Chemistry and Molecular Modelling, Institute of Advance Chemistry of Catalonia (IQAC-CSIC), Jordi Girona 18-26, 08034, Barcelona, Spain. ignacio.alfonso@iqac.csic.es.
authors.forename: Joan
authors.initials: J
authors.lastname: Atcher
authors.forename: Jordi
authors.initials: J
authors.lastname: Bujons
authors.forename: Ignacio
authors.initials: I
authors.lastname: Alfonso