title: [The efficacy of cyclosporine A as salvage therapy for severe active ulcerative colitis refractory to glucocorticoid].
abstract: Objective:To clarify the efficacy and safety of cyclosporine A (CsA) as salvage therapy in patients with severe active ulcerative colitis (UC) and refractory to steroids.Methods:A total of 24 severe active UC patients refractory to steroids and hospitalized from 2006 to 2012, were retrospectively enrolled.Data including demographic features, clinical manifestations, laboratory tests and medications were collected.Results:CsA was effective in 15(62.5%) patients, who did not receive colectomy during 12-week administration. This regimen was tolerable in most patients.Twelve (50.0%) patients reported 16 adverse events, but only one patient withdrew CsA due to intolerance.The rates of adverse events in initial intravenous CsA including 4 mg·kg(-1)·d(-1,) 3 mg·kg(-1)·d(-1) and 2 mg·kg(-1)·d(-1) were 2/2, 9/17 and 1/5 respectively.Responders had higher white blood cell count compared with non-responders (P= 0.045).Conclusions:CsA could be an effective alternative regimen to colectomy in severe active UC patients who are refractory to steroids.
authors.affiliation: Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: M M
authors.initials: MM
authors.lastname: Wei
authors.forename: G J
authors.initials: GJ
authors.lastname: Fei
authors.forename: Y L
authors.initials: YL
authors.lastname: Feng
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: G
authors.initials: G
authors.lastname: Lyu
authors.forename: H J
authors.initials: HJ
authors.lastname: Shu
authors.forename: J M
authors.initials: JM
authors.lastname: Qian
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012449:Safety; D016879:Salvage Therapy; D012720:Severity of Illness Index; D013256:Steroids; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D013256:Steroids; D016572:Cyclosporine
keywords: Colitis, ulcerative; Cyclosporine A; Retrospective studies; Steroid refractory