title: Study on the short-term effects of increased alcohol and cigarette consumption in healthy young men's seminal quality.
abstract: Many studies have reported a negative impact of lifestyle factors on testicular function, spermatozoa parameters and pituitary-gonadal axis. However, conclusions are difficult to draw, since studies in the general population are rare. In this study we intended to address the early and late short-term impact of acute lifestyle alterations on young men's reproductive function. Thirty-six healthy male students, who attended the Portuguese academic festivities, provided semen samples and answered questionnaires at three time-points. The consumption of alcohol and cigarette increased more than 8 and 2 times, respectively, during the academic festivities and resulted in deleterious effects on semen quality: one week after the festivities, a decrease on semen volume, spermatozoa motility and normal morphology was observed, in parallel with an increase on immotile spermatozoa, head and midpiece defects and spermatozoa oxidative stress. Additionally, three months after the academic festivities, besides the detrimental effect on volume, motility and morphology, a negative impact on spermatozoa concentration was observed, along with a decrease on epididymal, seminal vesicles and prostate function. This study contributed to understanding the pathophysiology underlying semen quality degradation induced by acute lifestyle alterations, suggesting that high alcohol and cigarette consumption are associated with decreased semen quality in healthy young men.
authors.affiliation: Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
authors.forename: Joana Vieira
authors.initials: JV
authors.lastname: Silva
authors.affiliation: Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
authors.forename: Daniel
authors.initials: D
authors.lastname: Cruz
authors.affiliation: Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
authors.forename: Mariana
authors.initials: M
authors.lastname: Gomes
authors.affiliation: Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
authors.forename: Bárbara Regadas
authors.initials: BR
authors.lastname: Correia
authors.affiliation: Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Freitas
authors.affiliation: Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
authors.forename: Luís
authors.initials: L
authors.lastname: Sousa
authors.affiliation: Ferticentro - Center for Fertility Studies, Praceta Prof. Robalo Cordeiro (Idealmed), Circular Externa de Coimbra, 3020-479 Coimbra, Portugal.
authors.forename: Vladimiro
authors.initials: V
authors.lastname: Silva
authors.affiliation: Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
authors.forename: Margarida
authors.initials: M
authors.lastname: Fardilha
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D050050:Protein Carbonylation; D012907:Smoking; D013081:Sperm Motility; D013094:Spermatozoa / Q000378:metabolism*; D000072105:Superoxide Dismutase-1 / Q000235:genetics / Q000378:metabolism; D011795:Surveys and Questionnaires; D014443:Tyrosine / Q000031:analogs & derivatives / Q000032:analysis; D055815:Young Adult
chemical_list: C002744:3-nitrotyrosine; D014443:Tyrosine; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase; D000072105:Superoxide Dismutase-1