title: Exploring the Link between the Germline and Somatic Genome in Cancer.
abstract: <b/> Carter and colleagues propose a systematic analysis of the germline and somatic genome in cancer. They identify interactions that occur between germline and somatic variants. This elucidates the function of the germline genome in the context of cancer risk and development.Cancer Discov; 7(4); 354-5. ©2017 AACRSee related article by Carter et al., p. 410.
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois.
authors.forename: Paul
authors.initials: P
authors.lastname: Geeleher
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois. rhuang@medicine.bsd.uchicago.edu.
authors.forename: R Stephanie
authors.initials: RS
authors.lastname: Huang
mesh_terms: D060965:Clonal Evolution / Q000235:genetics*; D015894:Genome, Human; D055106:Genome-Wide Association Study; D023281:Genomics; D018095:Germ-Line Mutation / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology