title: Association of Interleukin-10 Polymorphisms (rs1800872, rs1800871, and rs1800896) with Predisposition to IgA Nephropathy in a Chinese Han Population: A Case-Control Study.
abstract: OBJECTIVE
  IgA nephropathy (IgAN) is a common form of primary glomerulonephritis worldwide. Previous studies indicated that IL-10 single nucleotide polymorphisms (SNP) play an important role in IgAN pathogenesis, but the results were controversy. This study aimed to investigate the association between IL-10 SNPs (rs1800872, rs1800871, and rs1800896) with IgAN in a Chinese Han population.
  
  
  METHODS
  We conducted a case-control study that included 351 patients with IgAN and 310 age-, gender- and ethnicity-matched healthy controls. Three promoter SNPs (rs1800872, rs1800871, and rs1800896) of IL-10 were genotyped by Sequenom MassARRAY. Odds ratios (ORs) with 95% confidence intervals (CI) were used to assess the relationship with IgAN.
  
  
  RESULTS
  We found that the rs1800896 did not correlate with IgAN risk, whereas rs1800872 and rs1800871 were significantly associated with increased IgAN risk in all genetic models. The haplotype analysis indicated that the CCA haplotype was associated with increased IgAN risk (OR = 1.36; 95% CI = 1.05-1.75). Moreover, there were no associations between these SNPs and blood pressure or gender, whereas the rs1800896 variant was correlated with higher 24-hour urine protein in patients with IgAN.
  
  
  CONCLUSIONS
  Taken together, these results suggest that IL-10 is a susceptibility gene in patients with IgAN.
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Linting
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Rongguo
authors.initials: R
authors.lastname: Fu
authors.affiliation: Department of Nephrology, Hainan general hospital, Haikou, China.
authors.forename: Jiali
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Niu
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Ge
authors.affiliation: Department of Pathology, Xi'an, China.
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Oncology, Xi'an, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Oncology, Xi'an, China.
authors.forename: Xinghan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Hematology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Wanggang
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011507:Proteinuria; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: Case-control study; IL-10; IgA nephropathy; Susceptibility