title: Ceftolozane-tazobactam for the treatment of ventilator-associated infections by colistin-resistant Pseudomonas aeruginosa.
abstract: The use of colistin for the treatment of multiresistant bacteria has led to the emergence of colistin-resistant strains of Gram-negative bacilli. Treatment of infections caused by these pan-drug-resistant bacteria is difficult owing to the paucity of effective antibiotics. We report two cases of ventilator-associated respiratory infection caused by pan-drug-resistant, colistin-resistant Pseudomonas aeruginosa that were successfully treated with ceftolozane-tazobactam.
authors.affiliation: Francisco Álvarez Lerma, Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, Spain. Falvarez@parcdesalutmar.cat.
authors.forename: F
authors.initials: F
authors.lastname: Álvarez Lerma
authors.forename: R
authors.initials: R
authors.lastname: Muñoz Bermudez
authors.forename: S
authors.initials: S
authors.lastname: Grau
authors.forename: M P
authors.initials: MP
authors.lastname: Gracia Arnillas
authors.forename: L
authors.initials: L
authors.lastname: Sorli
authors.forename: L
authors.initials: L
authors.lastname: Recasens
authors.forename: M
authors.initials: M
authors.lastname: Mico García
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D003091:Colistin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D053717:Pneumonia, Ventilator-Associated / Q000188:drug therapy* / Q000382:microbiology; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D000078142:Tazobactam
chemical_list: D000209:Acute-Phase Proteins; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C000594038:ceftolozane, tazobactam drug combination; D010397:Penicillanic Acid; D000078142:Tazobactam; D003091:Colistin