title: Malignant acrospiroma: a case report in the era of next generation sequencing.
abstract: Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart.
  
  
  
  We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing.
  
  
  
  To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
authors.affiliation: Department of Internal Medicine, Wayne State University, School of Medicine, Detroit, MI, USA. mdiab@med.wayne.edu.
authors.forename: Maria
authors.identifier: 0000-0002-4809-9535
authors.initials: M
authors.lastname: Diab
authors.affiliation: Department of Pathology, Wayne State University, School of Medicine, Detroit, MI, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Gabali
authors.affiliation: Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
authors.forename: Muaiad
authors.initials: M
authors.lastname: Kittaneh
mesh_terms: D018250:Acrospiroma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D000368:Aged; D015894:Genome, Human; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D013544:Sweat Gland Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery
keywords: Acral; Acrospiroma; Case report; Malignant; Next generation