title: Participation of Purinergic P2X Receptors in the Thermoregulatory Response to Cooling.
abstract: We studied the role of purinergic P2X receptors in the body response to cooling. In experiments on rats, P2X receptor antagonist PPADS was administered in different modes, which resulted in changes of different characteristics of the thermoregulatory response to cold. Iontophoresis of P2X antagonist into the skin decreased the thermal thresholds of all thermoregulatory responses to cooling, which can attest to a modulating effect of P2X receptors on peripheral thermosensitive afferents. Intraperitoneal administration of P2X antagonist suppressed thermoregulatory activity of skeletal muscles (shivering) developing during cooling without changing the thresholds of thermoregulatory responses. The findings suggest that ATP and P2X receptors play an important role in the formation of the response to cooling.
authors.affiliation: Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. kozyreva@physiol.ru.
authors.forename: T V
authors.initials: TV
authors.lastname: Kozyreva
authors.affiliation: Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: E S
authors.initials: ES
authors.lastname: Meyta
authors.affiliation: Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Kozaruk
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation; D003080:Cold Temperature; D058639:Cold-Shock Response; D008297:Male; D010101:Oxygen Consumption; D058911:Purinergic P2X Receptor Agonists / Q000494:pharmacology; D058920:Purinergic P2X Receptor Antagonists / Q000494:pharmacology; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D017208:Rats, Wistar; D058469:Receptors, Purinergic P2X / Q000502:physiology*; D012768:Shivering / Q000187:drug effects; D012867:Skin / Q000098:blood supply; D012881:Skin Temperature; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D058911:Purinergic P2X Receptor Agonists; D058920:Purinergic P2X Receptor Antagonists; D058469:Receptors, Purinergic P2X; C077792:pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; D011732:Pyridoxal Phosphate; D000255:Adenosine Triphosphate
keywords: P2X receptors; PPADS; cold; thermoregulation