title: Direct Catalytic Asymmetric Reductive Amination of Aliphatic Ketones Utilizing Diphenylmethanamine as Coupling Partner.
abstract: The highly efficient direct catalytic reductive amination of ketones with diphenylmethanamine catalyzed by iridium-phosphoramidite complexes is described. As an effective coupling partner, diphenylmethanamine is suitable for a wide range of ketones to provide chiral amines in high yields and enantioselectivity. The chiral monodentate phosphoramidite ligands are tunable and competent to accommodate substrates with different structures.
authors.affiliation: College of Chemistry and Pharmacy, Northwest A&F University , 22 Xinong Road, Yangling, Shaanxi 712100, PR China.
authors.forename: Haizhou
authors.initials: H
authors.lastname: Huang
authors.affiliation: College of Chemistry and Pharmacy, Northwest A&F University , 22 Xinong Road, Yangling, Shaanxi 712100, PR China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: College of Chemistry and Pharmacy, Northwest A&F University , 22 Xinong Road, Yangling, Shaanxi 712100, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: College of Chemistry and Pharmacy, Northwest A&F University , 22 Xinong Road, Yangling, Shaanxi 712100, PR China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhou
authors.affiliation: College of Chemistry and Pharmacy, Northwest A&F University , 22 Xinong Road, Yangling, Shaanxi 712100, PR China.
authors.forename: Mingxin
authors.identifier: 0000-0002-5407-3403
authors.initials: M
authors.lastname: Chang