title: Obesity and kidney disease: Hidden consequences of the epidemic.
abstract: Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center; Nephrology Section, Memphis VA Medical Center, Memphis, TN, United States.
authors.forename: Csaba P
authors.initials: CP
authors.lastname: Kovesdy
authors.affiliation: Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
authors.forename: Susan
authors.initials: S
authors.lastname: Furth
authors.affiliation: CNR - IFC Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Zoccali
authors.affiliation: International Society of Nephrology, in collaboration with International Federation of Kidney Foundation, Rue des Fabriques 1B, 1000, Brussels, Belgium.
mesh_terms: D050154:Adiposity; D015992:Body Mass Index; D058872:Epidemics / Q000517:prevention & control; D015438:Health Behavior; D000070497:Healthy Lifestyle; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D015995:Prevalence; D065840:Protective Factors; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology / Q000517:prevention & control; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior