title: Bidirectional synaptic plasticity can explain bidirectional retrograde effects of emotion on memory.
abstract: Emotional events can either impair or enhance memory for immediately preceding items. The GANE model explains this bidirectional effect as a glutamate "priority" signal that modulates noradrenaline release depending on arousal state. We argue for an alternative explanation: that priority itself evokes phasic noradrenaline release. Thus, contrasting E-1 memory effects are explained by a mechanism based on the Bienenstock-Cooper-Munro theory.
authors.affiliation: Laboratory for Clinical Neuroscience,Centro de Tecnología Biomédica,Universidad Politecnica de Madrid,Pozuelo de Alarcón,Madrid 28223,Spainbryan.strange@upm.esana.galarza@ctb.upm.eswww.thestrangelab.org.
authors.forename: Bryan A
authors.initials: BA
authors.lastname: Strange
authors.affiliation: Laboratory for Clinical Neuroscience,Centro de Tecnología Biomédica,Universidad Politecnica de Madrid,Pozuelo de Alarcón,Madrid 28223,Spainbryan.strange@upm.esana.galarza@ctb.upm.eswww.thestrangelab.org.
authors.forename: Ana
authors.initials: A
authors.lastname: Galarza-Vallejo
mesh_terms: D001143:Arousal; D004644:Emotions; D006801:Humans; D008568:Memory; D009473:Neuronal Plasticity; D013997:Time Factors