title: Asymmetric Synthesis of (-)-Pterocarine and (-)-Galeon via Chiral Phase Transfer-Catalyzed Atropselective Formation of Diarylether Cyclophane Skeleton.
abstract: Pterocarine and galeon are typical examples of diarylether heptanoids (DAEHs) with planar chirality due to the strictly constrained conformations in their molecular skeletons. The characterized oxa[1,7]metapara-cyclophane motifs in DAEHs impose great challenges for their enantioselective synthesis. The asymmetric syntheses of (-)-pterocarine and (-)-galeon are demonstrated by employing a chiral phase transfer-catalyzed highly enantioselective SNAr cyclization as the key step for the formation of a diarylether cyclophane skeleton.
authors.affiliation: College of Pharmacy, Jinan University , No. 601 Huangpu Avenue West, Guangzhou, 510632, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
authors.affiliation: College of Pharmacy, Jinan University , No. 601 Huangpu Avenue West, Guangzhou, 510632, China.|College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology , Shijiazhuang 050018, China.
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Jinan University , No. 601 Huangpu Avenue West, Guangzhou, 510632, China.|College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology , Shijiazhuang 050018, China.
authors.forename: Huan
authors.initials: H
authors.lastname: He
authors.affiliation: College of Pharmacy, Jinan University , No. 601 Huangpu Avenue West, Guangzhou, 510632, China.
authors.forename: Qian
authors.identifier: 0000-0002-5700-3275
authors.initials: Q
authors.lastname: Cai