title: Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease.
abstract: Beyond their role as structural molecules, sphingolipids are involved in many important cellular processes including cell proliferation, apoptosis, inflammation, and migration. Altered sphingolipid metabolism is observed in many pathological conditions including gastrointestinal diseases. Inflammatory bowel disease (IBD) represents a state of complex, unpredictable, and destructive inflammation of unknown origin within the gastrointestinal tract. The mechanisms explaining the pathophysiology of IBD involve signal transduction pathways regulating gastro-intestinal system's immunity. Progressive intestinal tissue destruction observed in chronic inflammation may be associated with an increased risk of colon cancer. Sphingosine-1-phosphate (S1P), a sphingolipid metabolite, functions as a cofactor in inflammatory signaling and becomes a target in the treatment of IBD, which might prevent its conversion to cancer. This paper summarizes new findings indicating the impact of (S1P) on IBD development and IBD-associated carcinogenesis.
authors.affiliation: Holy Cross Oncology Center of Kielce, Artwińskiego 3, 25-734 Kielce, Poland. tomwollny@gmail.com.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Wollny
authors.affiliation: Holy Cross Oncology Center of Kielce, Artwińskiego 3, 25-734 Kielce, Poland. marzena.watek@wp.pl.|Department of Microbiology and Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Aleja IX Wieków Kielc, 25-317 Kielce, Poland. marzena.watek@wp.pl.
authors.forename: Marzena
authors.initials: M
authors.lastname: Wątek
authors.affiliation: Department of Microbiology and Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Aleja IX Wieków Kielc, 25-317 Kielce, Poland. bonita.durnas@onkol.kielce.pl.
authors.forename: Bonita
authors.initials: B
authors.lastname: Durnaś
authors.affiliation: Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, 15-222 Białystok, Poland. katia146@wp.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Niemirowicz
authors.affiliation: Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, 15-222 Białystok, Poland. ewelina.piktel@wp.pl.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Piktel
authors.affiliation: Department of Hygiene, Epidemiology and Ergonomics, Medical University of Białystok, 15-230 Białystok, Poland. mzpiotrowska@gmail.com.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Żendzian-Piotrowska
authors.affiliation: Holy Cross Oncology Center of Kielce, Artwińskiego 3, 25-734 Kielce, Poland. stanislaw.gozdz@onkol.kielce.pl.|Department of Microbiology and Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, Aleja IX Wieków Kielc, 25-317 Kielce, Poland. stanislaw.gozdz@onkol.kielce.pl.
authors.forename: Stanisław
authors.initials: S
authors.lastname: Góźdź
authors.affiliation: Department of Microbiological and Nanobiomedical Engineering, Medical University of Białystok, 15-222 Białystok, Poland. buckirobert@gmail.com.
authors.forename: Robert
authors.initials: R
authors.lastname: Bucki
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism* / Q000503:physiopathology; D008246:Lysophospholipids / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D012307:Risk Factors; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000502:physiology
chemical_list: D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine
keywords: cancer; inflammatory bowel disease; sphingosine-1-phosphate