title: MAOA rs1137070 and heroin addiction interactively alter gray matter volume of the salience network.
abstract: The rs1137070 polymorphism of monoamine oxidase A (MAOA) is associated with alcoholism and smoking behavior. However, the association between rs1137070 and heroin addiction remains unclear. In this study, we examined the allelic distribution of rs1137070 in 1,035 heroin abusers and 2,553 healthy controls and investigated the interactive effects of rs1137070 and heroin addiction on gray matter volume (GMV) based on 78 heroin abusers and 79 healthy controls. The C allele frequency of rs1137070 was significantly higher in heroin abusers. Heroin addiction and the rs1137070 variant interactively altered measures of GMV in the anterior cingulate cortex, orbital frontal cortex, temporal pole, and insula, which were correlated with cognitive function. Heroin abusers with the C allele had lower measures of GMV in these regions than the healthy controls with the same allele, whereas those with the T allele displayed a different trend. The altered brain regions were connected with white matter tracts, yielding a structural network that partially overlapped with the salience network. These findings suggest that the low activity-related C allele of MAOA rs1137070 is associated with an increase in the sensitivity to heroin addiction and the damaging effects of heroin abuse on cognition and the salience network.
authors.affiliation: National Institute on Drug Dependence, Peking University, Beijing 100191, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Linwen
authors.initials: L
authors.lastname: Liu
authors.affiliation: National Institute on Drug Dependence, Peking University, Beijing 100191, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Feng
authors.affiliation: Institute of Mental Health/Peking University Sixth Hospital and Key Laboratory of Mental Health, Peking University, Beijing 100191, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Yue
authors.affiliation: National Institute on Drug Dependence, Peking University, Beijing 100191, China.|Institute of Mental Health/Peking University Sixth Hospital and Key Laboratory of Mental Health, Peking University, Beijing 100191, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Fan
authors.affiliation: National Institute on Drug Dependence, Peking University, Beijing 100191, China.|Beijing Key Laboratory on Drug Dependence Research, Beijing 100191, China.|The State Key Laboratory of Natural and Biomimetic Drugs, Beijing 100191, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Shi
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology; D000483:Alleles; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D066128:Gray Matter / Q000503:physiopathology*; D006556:Heroin Dependence / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D013702:Temporal Lobe / Q000503:physiopathology; D066127:White Matter / Q000503:physiopathology
chemical_list: D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human