title: Coenzyme-A-Independent Transacylation System; Possible Involvement of Phospholipase A2 in Transacylation.
abstract: The coenzyme A (CoA)-independent transacylation system catalyzes fatty acid transfer from phospholipids to lysophospholipids in the absence of cofactors such as CoA. It prefers to use C20 and C22 polyunsaturated fatty acids such as arachidonic acid, which are esterified in the glycerophospholipid at thesn-2 position. This system can also acylate alkyl ether-linked lysophospholipids, is involved in the enrichment of arachidonic acid in alkyl ether-linked glycerophospholipids, and is critical for the metabolism of eicosanoids and platelet-activating factor. Despite their importance, the enzymes responsible for these reactions have yet to be identified. In this review, we describe the features of the Ca2+-independent, membrane-bound CoA-independent transacylation system and its selectivity for arachidonic acid. We also speculate on the involvement of phospholipase A2 in the CoA-independent transacylation reaction.
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. ayamashi@pharm.teikyo-u.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamashita
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. hayashiy@pharm.teikyo-u.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. n-matsu@pharm.teikyo-u.ac.jp.
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsumoto
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. ynsasaki@pharm.teikyo-u.ac.jp.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nemoto-Sasaki
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. zuml936@gmail.com.
authors.forename: Takanori
authors.initials: T
authors.lastname: Koizumi
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. onkoutokuzitu05790110@gmail.com.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Inagaki
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. s.oka@pharm.teikyo-u.ac.jp.
authors.forename: Saori
authors.initials: S
authors.lastname: Oka
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. tanikawa@pharm.teikyo-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanikawa
authors.affiliation: Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan. sugiurat@pharm.teikyo-u.ac.jp.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sugiura
keywords: CoA-independent transacylation system; acyltransferase; alkyl-ether linked phospholipid; cPLA2γ; eicosanoid; lysophospholipase/transacylation; lysophospholipid; phospholipase A2; platelet-activating factor