title: P. acnes-Driven Disease Pathology: Current Knowledge and Future Directions.
abstract: This review discusses the biology and behavior ofPropionibacterium acnes(P. acnes), a dominant bacterium species of the skin biogeography thought to be associated with transmission, recurrence and severity of disease. More specifically, we discuss the ability ofP. acnesto invade and persist in epithelial cells and circulating macrophages to subsequently induce bouts of sarcoidosis, low-grade inflammation and metastatic cell growth in the prostate gland. Finally, we discuss the possibility ofP. acnesinfiltrating the brain parenchyma to indirectly contribute to pathogenic processes in neurodegenerative disorders such as those observed in Parkinson's disease (PD).
authors.affiliation: Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
authors.forename: Joerg R
authors.initials: JR
authors.lastname: Leheste
authors.affiliation: Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Ruvolo
authors.affiliation: Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
authors.forename: Joanna E
authors.initials: JE
authors.lastname: Chrostowski
authors.affiliation: Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
authors.forename: Kristin
authors.initials: K
authors.lastname: Rivera
authors.affiliation: Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Husko
authors.affiliation: Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
authors.forename: Alyssa
authors.initials: A
authors.lastname: Miceli
authors.affiliation: Molecular Pathology Division, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA.
authors.forename: Martin K
authors.initials: MK
authors.lastname: Selig
authors.affiliation: Department of Biomedicine, Aarhus University Aarhus, Denmark.
authors.forename: Holger
authors.initials: H
authors.lastname: Brüggemann
authors.affiliation: Department of Biomedical Sciences, NYIT College of Osteopathic Medicine Old Westbury, NY, USA.
authors.forename: German
authors.initials: G
authors.lastname: Torres
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D008297:Male; D019636:Neurodegenerative Diseases / Q000382:microbiology* / Q000473:pathology; D011425:Propionibacterium acnes / Q000472:pathogenicity*; D011467:Prostate / Q000382:microbiology* / Q000473:pathology; D012507:Sarcoidosis / Q000382:microbiology* / Q000473:pathology; D012867:Skin / Q000382:microbiology* / Q000473:pathology
keywords: BPH; Parkinson disease; Propionibacterium acnes; prostate cancer; sarcoidosis