title: A Novelin vivoSystem to Test Bronchodilators.
abstract: The incidence and severity of asthma continue to rise worldwide. β-agonists are the most commonly prescribed therapeutic for asthma management but have less efficacy for some subsets of asthmatic patients and there are concerns surrounding the side effects from their long-term persistent use. The demand to develop novel asthma therapeutics highlights the need for a standardized approach to effectively screen and test potential bronchoprotective compounds using relevantin vivoanimal models. Here we describe a validated method of testing potential therapeutic compounds for their fast-acting efficacy during the midst of an induced bronchoconstriction in a house dust mite challenged animal model.
authors.affiliation: Department of Medicine, University of Arizona, Tucson, Arizona, USA.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Addison
authors.affiliation: SCIREQ Inc., Montreal, Québec, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Morse
authors.affiliation: SCIREQ Inc., Montreal, Québec, Canada.
authors.forename: Annette
authors.initials: A
authors.lastname: Robichaud
authors.affiliation: Pediatrics, University of Arizona, Tucson, Arizona, USA.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Daines
authors.affiliation: Department of Medicine, University of Arizona, Tucson, Arizona, USA; Immunobiology, University of Arizona, Tucson, Arizona, USA.
authors.forename: Julie G
authors.initials: JG
authors.lastname: Ledford
keywords: Asthma; Bronchodilators; in vivo