title: Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.
abstract: The structures of 12 new "enantiomeric"-like abyssomicin metabolites (abyssomicins M-X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding putative biosynthetic gene cluster.
authors.forename: Xiachang
authors.identifier: 0000-0002-1106-1904
authors.initials: X
authors.lastname: Wang
authors.forename: Sherif I
authors.initials: SI
authors.lastname: Elshahawi
authors.forename: Wenlong
authors.initials: W
authors.lastname: Cai
authors.forename: Yinan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Larissa V
authors.initials: LV
authors.lastname: Ponomareva
authors.forename: Xiabin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Center for Applied Energy Research, University of Kentucky , Lexington, Kentucky 40511, United States.
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Copley
authors.affiliation: Center for Applied Energy Research, University of Kentucky , Lexington, Kentucky 40511, United States.
authors.forename: James C
authors.identifier: 0000-0003-4694-2776
authors.initials: JC
authors.lastname: Hower
authors.forename: Chang-Guo
authors.initials: CG
authors.lastname: Zhan
authors.affiliation: Department of Chemistry, University of Kentucky , Lexington, Kentucky 40506, United States.
authors.forename: Sean
authors.initials: S
authors.lastname: Parkin
authors.forename: Jürgen
authors.initials: J
authors.lastname: Rohr
authors.forename: Steven G
authors.initials: SG
authors.lastname: Van Lanen
authors.forename: Khaled A
authors.initials: KA
authors.lastname: Shaaban
authors.forename: Jon S
authors.identifier: 0000-0002-7148-0721
authors.initials: JS
authors.lastname: Thorson
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification*; D003031:Coal; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D005810:Multigene Family; D019906:Nuclear Magnetic Resonance, Biomolecular; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D003031:Coal; D013141:Spiro Compounds