title: Abiraterone-induced rhabdomyolysis resulting in acute kidney injury: A case report and review of the literature.
abstract: Abiraterone, a CYP17 inhibitor, blocks androgen biosynthesis in multiple tissue types. In combination with prednisone, it is approved as a first-line treatment for metastatic castration-resistant prostate cancer. We present a case of rhabdomyolysis associated with abiraterone therapy resulting in acute on chronic kidney injury in a patient with metastatic castration-resistant prostate cancer. Strict monitoring should be employed in patients started on abiraterone who have additional risk factors for developing rhabdomyolysis.
authors.affiliation: 1 Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Dineen
authors.affiliation: 2 University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hansen
authors.affiliation: 2 University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Guancial
authors.affiliation: 2 University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: Sievert
authors.affiliation: 2 University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Sahasrabudhe
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D000368:Aged; D000736:Androstenes / Q000009:adverse effects*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D064129:Prostatic Neoplasms, Castration-Resistant / Q000150:complications / Q000188:drug therapy; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*
chemical_list: D000736:Androstenes; C089740:abiraterone
keywords: Abiraterone; acute kidney injury; rhabdomyolysis; statin