title: Functional network connectivity alterations in schizophrenia and depression.
abstract: There is a high degree of overlap between the symptoms of major depressive disorder (MDD) and schizophrenia, but it remains unclear whether the similar symptoms are derived from convergent alterations in functional network connectivity. In this study, we performed a group independent component analysis on resting-state functional MRI data from 20 MDD patients, 24 schizophrenia patients, and 43 matched healthy controls. The functional network connectivity analysis revealed that, compared to healthy controls, the MDD and schizophrenia patients exhibited convergent decreased positive connectivity between the left and right fronto-parietal control network and decreased negative connectivity between the left control and medial visual networks. Furthermore, the MDD patients showed decreased negative connectivity between the left control and auditory networks, and the schizophrenia patients showed decreased positive connectivity between the bilateral control and language networks and decreased negative connectivity between the right control and dorsal attention networks. The convergent network connectivity alterations may underlie the common primary control and regulation disorders, and the divergent connectivity alterations may enable the distinction between the two disorders. All of the convergent and divergent network connectivity alterations were relevant to the control network, suggesting an important role of the network in the pathophysiology of MDD and schizophrenia.
authors.affiliation: Department of Control Engineering, Naval Aeronautical and Astronautical University, Yantai, Shandong 264001, China; College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Wu
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Zeng
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shen
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Qin
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China. Electronic address: dwhu@nudt.edu.cn.
authors.forename: Dewen
authors.initials: D
authors.lastname: Hu
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000000981:diagnostic imaging* / Q000503:physiopathology; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000503:physiopathology
keywords: Fronto-parietal control network; Functional MRI; Functional network connectivity; Major depressive disorder; Schizophrenia