title: Image of the Month: Multifocal 68Ga Prostate-Specific Membrane Antigen Ligand Uptake in the Skeleton in a Man With Both Prostate Cancer and Multiple Myeloma.
abstract: Ga prostate-specific membrane antigen (PSMA) HBED-CC PET/CT in a 65-year-old man with first diagnosis of prostate cancer (PC) and a history of multiple myeloma showing multifocal PSMA ligand uptake in the skeleton with corresponding osteolytic lesions in CT. Although osteolytic bone metastases are very rare in PC, PSMA expression in PET raised the suspicion of PC bone metastases. Bone marrow biopsy excluded PC metastases with immunohistochemistry showing endothelial expression of PSMA in small vessels within the myeloma.
authors.affiliation: From the Departments of *Nuclear Medicine, †Urology, and ‡Pathology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.
authors.forename: Isabel
authors.initials: I
authors.lastname: Rauscher
authors.forename: Tobias
authors.initials: T
authors.lastname: Maurer
authors.forename: Katja
authors.initials: K
authors.lastname: Steiger
authors.forename: Markus
authors.initials: M
authors.lastname: Schwaiger
authors.forename: Matthias
authors.initials: M
authors.lastname: Eiber
mesh_terms: D000954:Antigens, Surface / Q000378:metabolism*; D001692:Biological Transport; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D005710:Gallium Radioisotopes; D043425:Glutamate Carboxypeptidase II / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism*; D000072078:Positron Emission Tomography Computed Tomography; D011471:Prostatic Neoplasms / Q000150:complications*
chemical_list: D000954:Antigens, Surface; D005710:Gallium Radioisotopes; D008024:Ligands; C075313:N,N'-bis(2-hydroxy-5-(ethylene-beta-carboxy)benzyl)ethylenediamine N,N'-diacetic acid; D004492:Edetic Acid; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II