title: Effects of Growth Factors on Mobilization of Mesenchymal Stem Cells.
abstract: We studied mobilization of bone marrow stem cells the under conditions of boost-therapy with granulocytic CSF and erythropoietin. Immunophenotyping of the peripheral blood was carried out in patients after transplantation of tissue-engineered trachea during the perioperative period. We observed an increase in hemopoietic stem cell pool and appearance of multipotent mesenchymal stromal cells in systemic circulation, their maximum concentration being recorded on days 10-14 after surgery. These data indicated a positive effect of growth factors on mobilization of stem cells.
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Gilevich
authors.affiliation: S. V. Ochapovsky Regional Clinical Hospital No. 1, Krasnodar, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Fedorenko
authors.affiliation: S. V. Ochapovsky Regional Clinical Hospital No. 1, Krasnodar, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Pashkova
authors.affiliation: S. V. Ochapovsky Regional Clinical Hospital No. 1, Krasnodar, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Porkhanov
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D004921:Erythropoietin / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000502:physiology*; D054457:Tissue Scaffolds; D014132:Trachea / Q000601:surgery; D014135:Tracheal Stenosis / Q000097:blood / Q000188:drug therapy / Q000601:surgery*
chemical_list: D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor
keywords: erythropoietin; granulocytic colony-stimulating factor; stem cells