title: Submandibular salivary gland tumors: Clinical course and outcome of a 20-year multicenter study.
abstract: The purpose of this retrospective chart review study was to review the nature and clinical course of benign and malignant submandibular gland tumors at 2 major university-affiliated tertiary medical centers. All patients who underwent submandibular salivary gland excision between 1990 and 2010 were included. Clinical and disease-related data were collected from the medical charts. One hundred ninety-three patients were identified, of whom 108 (56%) had non-neoplastic disorders (sialolithiasis and sialadenitis). The remaining 85 patients (44%) had a submandibular salivary gland tumor. The most common benign neoplasm was pleomorphic adenoma (53 patients). Twenty tumors (24%) were malignant: adenoid cystic carcinoma in 11 patients, mucoepidermoid carcinoma in 6 patients, and adenocarcinoma in 3 patients. Recurrence was noted in 7 patients with submandibular gland malignancy and in 2 patients with pleomorphic adenoma. The 5-year disease-free survival rate was 63%. Tumors of the submandibular gland are infrequently malignant. Recurrent submandibular salivary gland pleomorphic adenoma is rare compared with recurrences in the parotid gland.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tikva 49100, Israel. aviramguy@hotmail.com.
authors.forename: Aviram
authors.initials: A
authors.lastname: Mizrachi
authors.forename: Gideon
authors.initials: G
authors.lastname: Bachar
authors.forename: Yaron
authors.initials: Y
authors.lastname: Unger
authors.forename: Ohad
authors.initials: O
authors.lastname: Hilly
authors.forename: Dan M
authors.initials: DM
authors.lastname: Fliss
authors.forename: Thomas
authors.initials: T
authors.lastname: Shpitzer
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology*; D008949:Adenoma, Pleomorphic / Q000453:epidemiology / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000453:epidemiology / Q000473:pathology*; D018277:Carcinoma, Mucoepidermoid / Q000453:epidemiology / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology; D063868:Patient Outcome Assessment; D012042:Registries; D012189:Retrospective Studies; D013365:Submandibular Gland Neoplasms / Q000453:epidemiology / Q000473:pathology*; D013997:Time Factors; D055815:Young Adult