title: Memory B cells: total recall.
abstract: Immunological memory is a cornerstone of adaptive immune responses in higher vertebrates. The remarkable ability to generate memory cells following Ag exposure, in the context of natural infection or immunization, provides long-lived protection against infectious diseases, often for the hosts' lifetime. Indeed, the generation of memory B cells and long-lived plasma cells underpins the success of most vaccines. The concept of immunological memory is not new-it was first proposed nearly 2500 years ago. While our understanding of the complexities of humoral and cell-mediated memory continues to evolve, important aspects of this process remain unresolved. Here, we will provide an overview of recent advances in B-cell memory in mice and humans, and in health and disease.
authors.affiliation: Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, University of NSW, Australia. Electronic address: t.phan@garvan.org.au.
authors.forename: Tri Giang
authors.initials: TG
authors.lastname: Phan
authors.affiliation: Immunology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; St Vincent's Clinical School, University of NSW, Australia. Electronic address: s.tangye@garvan.org.au.
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Tangye
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology* / Q000473:pathology; D051379:Mice; D010950:Plasma Cells / Q000276:immunology* / Q000473:pathology
chemical_list: D000941:Antigens