title: Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of theMC4Rgene in postmenopausal women.
abstract: Metabolic syndrome (MS) is widespread in the human population, and its incidence is continuously increasing, generating serious health problems. The purpose of this study was to find the relationship between the parameters of MS and the melanocortin type 4 receptor (MC4R) gene polymorphism in postmenopausal women. The study involved 344 healthy Polish women, who had their last menstrual cycle 1 year ago or earlier. The study included blood analysis, survey, and body measurements. The mean age was 58.5±6.6 years. An increased body mass index was observed in 65.7% and abdominal obesity in 80.3% of the study population. MS was diagnosed in 40.7% of all participants, including 39.3% of women with the T/T genotype and 44.7% of those with the C/X genotype (χ2test;P>0.05). A logistic regression model showed that the probability of MS was higher in patients with the C/X genotype (odds ratio =1.25) (χ2test;P>0.05). The study concluded that MS is a very common condition among postmenopausal women. The C/X genotype of theMC4Rgene seems to predispose postmenopausal women to developing some MS symptoms.
authors.affiliation: Primary Care Department, Pomeranian Medical University in Szczecin.
authors.forename: Jacek
authors.initials: J
authors.lastname: Brodowski
authors.affiliation: Department of Nursing, Pomeranian Medical University in Szczecin.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szkup
authors.affiliation: Department of Nursing, Pomeranian Medical University in Szczecin.
authors.forename: Anna
authors.initials: A
authors.lastname: Jurczak
authors.affiliation: Department of Nursing, Pomeranian Medical University in Szczecin.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Wieder-Huszla
authors.affiliation: Clinic of Gynecology, Endocrinology, and Gynecologic Oncology, Pomeranian Medical University in Szczecin.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Brodowska
authors.affiliation: Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin.
authors.forename: Maria
authors.initials: M
authors.lastname: Laszczyńska
authors.affiliation: Public Health Department, Pomeranian Medical University in Szczecin, Żołnierska, Szczecin, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Karakiewicz
authors.affiliation: Primary Care Department, Pomeranian Medical University in Szczecin.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kęcka
authors.affiliation: Department of Nursing, Pomeranian Medical University in Szczecin.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Grochans
mesh_terms: D000368:Aged; D015992:Body Mass Index; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D017698:Postmenopause; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*
chemical_list: C470072:MC4R protein, human; D044105:Receptor, Melanocortin, Type 4
keywords: melanocortin type 4 receptor (MC4R); metabolic syndrome; postmenopausal women