title: Effects of testosterone replacement therapy on hypogonadal men with osteopenia or osteoporosis: a subanalysis of a prospective randomized controlled study in Japan (EARTH study).
abstract: OBJECTIVE
  We investigated the effects of testosterone replacement therapy (TRT) on bone mineral density (BMD) among hypogonadal men with osteopenia/osteoporosis.
  
  
  METHODS
  From our previous EARTH study population, 74 patients with a clinical diagnosis of osteopenia or osteoporosis and hypogonadism were included in this study, as the TRT (n = 35) and control (n = 34) groups. The TRT group was administered 250 mg of testosterone enanthate injection every 4 weeks for 12 months. The BMD, waist circumference, body mass index, body fat percentage, and muscle volume were measured at baseline and at 12 months. Blood biochemical data, including total cholesterol, triglycerides, HDL-cholesterol, hemoglobin A1c, and adiponectin values were also evaluated.
  
  
  RESULTS
  At the 12-month visit, BMD significantly increased in both groups. However, comparisons on changes of parameter values from baseline to the 12-month visit between the TRT and control groups were significantly different in BMD (5.0 ± 5.0 vs. 3.0 ± 3.2; p = .0434) and in adiponectin value (-0.90 ± 3.33 vs. 0.10 ± 2.04; p = .0192). There were no significant changes in other parameters.
  
  
  CONCLUSIONS
  TRT for 12 months could improve BMD with a decrease in adiponectin levels among hypogonadal men with osteopenia/osteoporosis.
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Shigehara
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Konaka
authors.affiliation: b Komagane Urological Clinic , Nagano , Japan.
authors.forename: Eitetsu
authors.initials: E
authors.lastname: Koh
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nakashima
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Iijima
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nohara
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Izumi
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kitagawa
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kadono
authors.affiliation: c Department of Urology , Itaya Clinic , Kaga , Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: d Division of Male Infertility , Center for Infertility and IVF, International University of Health and Welfare , Nasushiobara , Japan.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Iwamoto
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizokami
authors.affiliation: a Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa , Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Namiki
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D000728:Androgens / Q000008:administration & dosage*; D015519:Bone Density / Q000187:drug effects*; D016022:Case-Control Studies; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007273:Injections, Intramuscular; D007564:Japan; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D000728:Androgens; D013739:Testosterone; C004648:testosterone enanthate
keywords: Late-onset hypogonadism; bone mineral density; osteopenia; testosterone replacement therapy