title: [Epidemiology of Campylobacteriosis in Castile and Leon, Spain,during the period 2008-2015].
abstract: OBJECTIVE
  Campylobacter is considered the most frequent agent of gastroenteritis in humans all around the world. The aim of this study was to know the incidence, trend and seasonality of notified campylobacteriosis cases in Castile and Leon, Spain, from 2008 to 2015. In addition, to describe the type of case and source of notification, and study the influence of age, sex and Campylobacter species on the hospitalization of cases.
  
  
  METHODS
  Retrospective cross-sectional study with a time series analysis. Data on notified campylobacteriosis cases were collected from the Epidemiological Surveillance System of Castile and Leon (2008-2015). Incidence rates and incidence rate ratios by age, sex and year of notification were calculated. In order to estimate trend and seasonality, a time series analysis was performed using a multiplicative method and adjusted to a linear and exponential model.
  
  
  RESULTS
  From 4,330 cases analyzed, 49.4% of children aged under 5 were affected. The ratio of men to women was 1.43 and 61.8% of cases were notified from secondary care. C. jejuni was isolated from 72.3% of samples (n=2,593). Incidence rate ranged from 11.42 cases per 100,000 inhabitants in 2008 to 33.53 in 2015. The seasonality range was from 71.97% (13th four-week period) to 125.54% (9th four-week period). Hospitalization reached 62.5% for people aged 60 or over.
  
  
  CONCLUSIONS
  A growing trend of notified campylobacteriosis cases is observed in Castile and Leon (2008-2015), mainly in children aged under 5, with a peak in summer months. Males are more affected than females and hospitalization increases with age.
authors.affiliation: Servicio de Medicina Preventiva. Hospital Universitario de Burgos. Burgos. España.
authors.forename: Belén
authors.initials: B
authors.lastname: Berradre-Sáenz
authors.affiliation: Sección de Epidemiología. Servicio Territorial de Sanidad y Bienestar Social de la Junta de Castilla y León. Burgos. España.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Yáñez-Ortega
authors.affiliation: Departamento de Biotecnología y Ciencia de los Alimentos. Facultad de Ciencias. Universidad de Burgos. Burgos. España.
authors.forename: Lourdes
authors.initials: L
authors.lastname: García-Sánchez
authors.affiliation: Departamento de Biotecnología y Ciencia de los Alimentos. Facultad de Ciencias. Universidad de Burgos. Burgos. España.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Melero-Gil
authors.affiliation: Departamento de Biotecnología y Ciencia de los Alimentos. Facultad de Ciencias. Universidad de Burgos. Burgos. España.
authors.forename: Jordi
authors.initials: J
authors.lastname: Rovira-Carballido
authors.affiliation: Sección de Epidemiología. Servicio Territorial de Sanidad y Bienestar Social de la Junta de Castilla y León. Burgos. España.
authors.forename: Isabel
authors.initials: I
authors.lastname: Carramiñana-Martínez
authors.affiliation: Servicio de Medicina Preventiva. Hospital Universitario de Burgos. Burgos. España.
authors.forename: Silvia
authors.initials: S
authors.lastname: Tejero-Encinas
authors.affiliation: Servicio de Epidemiología. Consejería de Sanidad. Dirección General de Salud Pública. Valladolid. España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ruiz-Sopeña
authors.affiliation: Servicio de Epidemiología. Consejería de Sanidad. Dirección General de Salud Pública. Valladolid. España.
authors.forename: Socorro
authors.initials: S
authors.lastname: Fernández-Arribas
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002169:Campylobacter Infections / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012621:Seasons; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
keywords: Campylobacter; Communicable diseases; Foodborne diseases; Incidence; Seasons; Spain; Surveillance; Time Series Studies; Trends [Subheading]; Zoonoses