title: Advance of DNA and CCPs-based nanocarriers in drug delivery systems.
abstract: Development of smart and functional polymeric carriers, which enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects, becomes a new requirement in the field of drug delivery. In the recent few decades, a great many advancements of polymer synthetic methods have led to a new generation of bioactive polymers' applications as drug controlled release carriers. In this review, we focus on the use of bioactive polymers for drug delivery system, with a particular in the utility of DNA-based nanocarriers and cell-penetrating peptides (CCPs)-based nanocarriers to provide precision control for drug targeting or stimuli responsive systems.
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Xihui
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Yinping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Weiqun
authors.initials: W
authors.lastname: Tian
mesh_terms: D000818:Animals; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D057846:Cell-Penetrating Peptides; D004337:Drug Carriers; D004247:DNA
keywords: DNA; cell-penetrating peptides; drug delivery systems; nanocarriers; targeting