title: Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology.
abstract: Many proteins and cargoes in eukaryotic cells are secreted through the conventional secretory pathway that brings proteins and membranes from the endoplasmic reticulum to the plasma membrane, passing through various cell compartments, and then the extracellular space. The recent identification of an increasing number of leaderless secreted proteins bypassing the Golgi apparatus unveiled the existence of alternative protein secretion pathways. Moreover, other unconventional routes for secretion of soluble or transmembrane proteins with initial endoplasmic reticulum localization were identified. Furthermore, other proteins normally functioning in conventional membrane traffic or in the biogenesis of unique plant/fungi organelles or in plasmodesmata transport seem to be involved in unconventional secretory pathways. These alternative pathways are functionally related to biotic stress and development, and are becoming more and more important in cell biology studies in yeast, mammalian cells and in plants. The city of Lecce hosted specialists working on mammals, plants and microorganisms for the inaugural meeting on "Unconventional Protein and Membrane Traffic" (UPMT) during 4-7 October 2016. The main aim of the meeting was to include the highest number of topics, summarized in this report, related to the unconventional transport routes of protein and membranes.
authors.affiliation: Institute of Biosciences and Bioresources-Research Division of Perugia, National Research Council (CNR), via della Madonna Alta 130, 06128 Perugia, Italy. andrea.pompa@ibbr.cnr.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pompa
authors.affiliation: Institute of Biosciences and Bioresources-Research Division of Perugia, National Research Council (CNR), via della Madonna Alta 130, 06128 Perugia, Italy. francesca.demarchis@ibbr.cnr.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: De Marchis
authors.affiliation: Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy. maria.pallotta@unipg.it.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Pallotta
authors.affiliation: Centre for Plant Science, School of Biology, University of Leeds, Leeds LS2 9JT, UK. Y.Benitez-Alfonso@leeds.ac.uk.
authors.forename: Yoselin
authors.initials: Y
authors.lastname: Benitez-Alfonso
authors.affiliation: School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK. alex.jones@warwick.ac.uk.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Jones
authors.affiliation: Institute for Microbiology, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany. kerstin.schipper@uni-duesseldorf.de.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Schipper
authors.affiliation: Clinical Biochemistry, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 1TN, UK. km510@cam.ac.uk.
authors.forename: Kevin
authors.initials: K
authors.lastname: Moreau
authors.affiliation: Department of Experimental Plant Biology, Faculty of Science, Charles University, 12844, Prague 2, Czech Republic. zarsky@ueb.cas.cz.|Institute of Experimental Botany, v.v.i., the Czech Academy of Sciences, 16502, Prague 6, Czech Republic. zarsky@ueb.cas.cz.
authors.forename: Viktor
authors.initials: V
authors.lastname: Žárský
authors.affiliation: Department of Biological and Environmental Sciences and Technologies (DISTEBA), University of Salento, S.P. 6, 73100 Lecce, Italy. gp.disansebastiano@unisalento.it.
authors.forename: Gian Pietro
authors.initials: GP
authors.lastname: Di Sansebastiano
authors.affiliation: Institute of Biosciences and Bioresources-Research Division of Perugia, National Research Council (CNR), via della Madonna Alta 130, 06128 Perugia, Italy. michele.bellucci@ibbr.cnr.it.
authors.forename: Michele
authors.initials: M
authors.lastname: Bellucci
mesh_terms: D000818:Animals; D003585:Cell Biology; D015509:Developmental Biology; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D021381:Protein Transport
chemical_list: D008565:Membrane Proteins
keywords: autophagy; exosomes; intercellular channels; leaderless proteins; protein secretion; trafficking mechanisms; unconventional secretion