title: N-Heterocyclic Carbene Catalyzed 1,6-Conjugate Addition of Me3Si-CN to para-Quinone Methides and Fuchsones: Access to α-Arylated Nitriles.
abstract: An organocatalytic approach toward α-arylated nitriles using N-heterocyclic carbene (NHC) as a catalyst is described. This protocol comprises an NHC catalyzed activation of Me3Si-CN followed by 1,6-conjugate addition of cyanide to para-quinone methides (p-QMs) and fuchsones leading to α-diaryl- and α-triaryl nitriles in good to excellent yields.
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali , Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab - 140306, India.
authors.forename: Prithwish
authors.initials: P
authors.lastname: Goswami
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali , Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab - 140306, India.
authors.forename: Gurdeep
authors.initials: G
authors.lastname: Singh
authors.affiliation: Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali , Sector 81, Knowledge City, S. A. S. Nagar, Manauli (PO), Punjab - 140306, India.
authors.forename: Ramasamy
authors.identifier: 0000-0001-9490-4569
authors.initials: R
authors.lastname: Vijaya Anand