title: Asymmetric hydrogenation of maleic anhydrides catalyzed by Rh/bisphosphine-thiourea: efficient construction of chiral succinic anhydrides.
abstract: Asymmetric hydrogenation of various 3-substituted maleic anhydrides catalyzed by Rh/bisphosphine-thiourea (ZhaoPhos) under mild conditions was successfully developed. A wide range of 3-alkyl and 3-aryl maleic anhydrides were hydrogenated well to provide the desired products 3-substituted succinic anhydrides in one hour with excellent results (full conversions, up to 99% yield, 99% ee, 3000 TON). Importantly, we developed a creative and efficient synthetic route to construct the key intermediate of the hypoglycemic drug mitiglinide through our catalytic system.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. xumu@whu.edu.cn xiuqindong@whu.edu.cn.
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Han
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Guoxian
authors.initials: G
authors.lastname: Gu
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang