title: The Effect of Triglyceride Concentration on Attainment of Lipid Targets in Patients with Diabetes.
abstract: OBJECTIVE
  To evaluate the effects of triglyceride (TG) and glycated hemoglobin (A1C) concentrations in the percentage of patients with diabetes who are within target (WT) for low-density lipoprotein-cholesterol (LDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C) and apolipoprotein B (ApoB), as defined by the Canadian Lipid Guidelines, in a cohort of outpatients presenting at a 350-bed community hospital.
  
  
  METHODS
  Laboratory samples from 1919 patients, 18 years or older, who had A1C levels of 6.5% or above were used. Fasting lipid profiles were retrieved, and ApoB was measured.
  
  
  RESULTS
  We found no significant difference in the percentage of those WT for LDL-C as TG increased from normal to intermediate and high levels. For non-HDL-C, we saw a substantial decrease in the percentage of patients WT as TG levels increased from normal (61%) to intermediate (30.4%) and high levels (14.0%). ApoB showed a similar pattern to non-HDL-C: decreasing from normal (68.8%) to intermediate (40.7%) and high levels (21.0%). No significant difference was seen in the percentage of patients WT for the 3 lipid parameters studied with the increase in A1C levels.
  
  
  CONCLUSIONS
  As TG increases, we saw discordance in the percentage of patients WT for LDL-C in relation to non-HDL-C and ApoB. Alternative targets to LDL-C should preferentially be used when the TG concentration is elevated.
authors.affiliation: The Moncton Hospital, Horizon Health Network, Moncton, New Brunswick, Canada. Electronic address: Dr.Louis.Cartier@horizonnb.ca.
authors.forename: Louis-Jacques
authors.initials: LJ
authors.lastname: Cartier
authors.affiliation: The Moncton Hospital, Horizon Health Network, Moncton, New Brunswick, Canada.
authors.forename: Charlene
authors.initials: C
authors.lastname: Collins
authors.affiliation: The Moncton Hospital, Horizon Health Network, Moncton, New Brunswick, Canada.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Lagacé
authors.affiliation: Centre Hospitalier Universitaire de Québec, Québec City, Québec, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Douville
mesh_terms: D000368:Aged; D001055:Apolipoproteins B / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D008055:Lipids; D014280:Triglycerides
keywords: cibles lipidiques; clinical practice guidelines; diabetes; diabète; glycated hemoglobin (A1C); hémoglobine glyquée (A1c); lignes directrices de pratique clinique; lipid target; triglycerides (TG); triglycérides (TG)