title: Effect of universal chlorhexidine decolonisation on the infection rate in intensive care patients.
abstract: BACKGROUND
  Healthcare-associated infections (HAIs), particularly intensive care unit-acquired infections (HAI-ICU), are an important cause of morbidity and mortality in hospitals. Most of these infections are caused by multidrugresistant organisms. The results of recent studies have suggested that daily bathing with chlorhexidine (CHX)-universal decolonisation can prevent ICU infections. The purpose of the study was to determine the influence of CHX bathing on the rate and type of HAI-ICU in critically ill patients.
  
  
  METHODS
  This observational study, conducted in a mixed, 16-bed tertiary ICU, compared the following three 3-month periods: I) pre-intervention (traditional soap-water bathing), II) intervention (bathing with 2% CHX clothes), and III) post-intervention (soap-water bathing). The type and rate of HAI-ICU were registered according to the European Centre for Disease Prevention and Control (ECDC) guidelines.
  
  
  RESULTS
  A total of 272 patients were included in the study. During the intervention period, the total infection rate was significantly lower than in the pre-intervention period (12.7% vs 22.2%, respectively). Significant decreases in the rate and density of catheter-related infections (CRI) were observed during the intervention period. A decrease in the isolation rate of multidrug-resistant bacteria was also observed during the intervention and post-intervention periods.
  
  
  CONCLUSIONS
  Daily bathing of ICU patients with chlorhexidine-impregnated clothes significantly decreased the rate of HAI-ICU and the acquisition of CRI. This simple hygienic approach can be an important adjunctive intervention with the capability of reducing the burden of healthcare-associated infections in ICUs.
authors.forename: Wiesława
authors.initials: W
authors.lastname: Duszyńska
authors.forename: Barbara
authors.initials: B
authors.lastname: Adamik
authors.forename: Karolina
authors.initials: K
authors.lastname: Lentka-Bera
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kulpa
authors.forename: Agata
authors.initials: A
authors.lastname: Nieckula-Schwarz
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Litwin
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Stróżecki
authors.affiliation: Department of Anaesthesiology and Intensive Therapy, Wrocław Medical University, Wrocław, Poland. kai@umed.wroc.pl.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kübler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001494:Baths; D055499:Catheter-Related Infections / Q000453:epidemiology / Q000517:prevention & control; D002710:Chlorhexidine / Q000008:administration & dosage*; D003422:Critical Care / Q000379:methods; D016638:Critical Illness; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control*; D004202:Disinfectants / Q000008:administration & dosage; D004203:Disinfection / Q000379:methods; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000891:Anti-Infective Agents, Local; D004202:Disinfectants; D002710:Chlorhexidine
keywords: antiseptic; catheter-related infections; chlorhexidine; decolonization; healthcare-associated infections; intensive care unit; multidrug-resistant pathogens; skin; universal