title: Ternary choline chloride/caffeic acid/ethylene glycol deep eutectic solvent as both a monomer and template in a molecularly imprinted polymer.
abstract: A molecularly imprinted polymer based on a ternary deep eutectic solvent comprised of choline chloride/caffeic acid/ethylene glycol was prepared. The caffeic acid in the ternary deep eutectic solvent was used as both a monomer and template. The molecularly imprinted polymer based on the ternary deep eutectic solvent was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, field-emission scanning electron microscopy, Brunauer-Emmett-Teller surface area analysis, atomic force microscopy, and elemental analysis. A series of molecularly imprinted polymers based on choline chloride/caffeic acid/ethylene glycol with different molar ratios was prepared and applied to the molecular recognition of polyphenols. A comparison of the recognition ability of molecularly imprinted polymers to polyphenols revealed that the choline chloride/caffeic acid/ethylene glycol (1:0.4:1, molar ratio) molecularly imprinted polymer had the best molecular recognition effect with 132 μg/g of protocatechuic acid, 104 μg/g of catechins, 80 μg/g of epicatechin, and 123 μg/g of caffeic acid in 6 h, as well as good molecular recognition ability for polyphenols from a Radix Asteris sample. These results show that the ternary deep eutectic solvent based molecularly imprinted polymer is a potential medium that can be applied to drug purification, drug delivery, and drug analysis.
authors.affiliation: College of Pharmaceutical Science, Hebei University, Baoding, China.
authors.forename: Najing
authors.initials: N
authors.lastname: Fu
authors.affiliation: College of Pharmaceutical Science, Hebei University, Baoding, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Pharmaceutical Science, Hebei University, Baoding, China.
authors.forename: Liteng
authors.initials: L
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Science, Hebei University, Baoding, China.
authors.forename: Baokun
authors.identifier: http://orcid.org/0000-0001-8679-972X
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Chemistry and Chemical Engineering, Inha University, Incheon, Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Row
mesh_terms: D002109:Caffeic Acids / Q000737:chemistry*; D002794:Choline / Q000737:chemistry*; D019855:Ethylene Glycol / Q000737:chemistry*; D054802:Molecular Imprinting; D011108:Polymers; D012997:Solvents
chemical_list: D002109:Caffeic Acids; D011108:Polymers; D012997:Solvents; D019855:Ethylene Glycol; D002794:Choline
keywords: deep eutectic solvents; molecular recognition; molecularly imprinted polymers; polyphenols