title: Behind the Scenes: Endo/Exocytosis in the Acquisition of Metastatic Traits.
abstract: Alterations of endo/exocytic proteins have long been associated with malignant transformation, and genes encoding membrane trafficking proteins have been identified asbona fidedrivers of tumorigenesis. Focusing on the mechanisms underlying the impact of endo/exocytic proteins in cancer, a scenario emerges in which altered trafficking routes/networks appear to be preferentially involved in the acquisition of prometastatic traits. This involvement in metastasis frequently occurs through the integration of programs leading to migratory/invasive phenotypes, survival and resistance to environmental stresses, epithelial-to-mesenchymal transition, and the emergence of cancer stem cells. These findings might have important implications in the clinical setting for the development of metastasis-specific drugs and for patient stratification to optimize the use of available therapies.Cancer Res; 77(8); 1813-7. ©2017 AACR.
authors.affiliation: Membrane Trafficking Laboratory at Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Italy. pierpaolo.difiore@ifom.eu letizia.lanzetti@ircc.it.|Department of Oncology, University of Turin Medical School, Turin, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Lanzetti
authors.affiliation: IFOM, The FIRC Institute for Molecular Oncology Foundation, Milan, Italy. pierpaolo.difiore@ifom.eu letizia.lanzetti@ircc.it.|DIPO, Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.|Molecular Medicine Program, European Institute of Oncology, Milan, Italy.
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Di Fiore
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism / Q000473:pathology; D002462:Cell Membrane / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D020691:rab GTP-Binding Proteins / Q000378:metabolism
chemical_list: D020691:rab GTP-Binding Proteins