title: Preventive effect ofCoriandrum sativumon neuronal damages in pentylentetrazole-induced seizure in rats.
abstract: OBJECTIVE
  Coriandrum sativum(C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure.
  
  
  METHODS
  Forty male rats were divided into five main groups and treated by (1) saline, (2) PTZ: 100 mg/kg PTZ (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract ofC. sativumduring seven consecutive days before PTZ injection. After electrocorticography (ECoG), the brains were removed to use for histological examination.
  
  
  RESULTS
  All doses of the extract reduced duration, frequency and amplitude of the burst discharges while prolonged the latency of the seizure attacks (p<0.05, p<0.01, and p<0.001). Administration of all 3 doses of the extract significantly prevented from production of dark neurons (p<0.01, and p<0.001) and apoptotic cells (p<0.05, p<0.01, and p<0.001) in different areas of the hippocampus compared to PTZ group.
  
  
  CONCLUSIONS
  The results of this study allow us to conclude thatC. sativum, because of its antioxidant properties, prevents from neuronal damages in PTZ rat model of seizure.
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Pourzaki
authors.affiliation: Pharmacological Research Center of Medicinal Plants , School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mansour
authors.initials: M
authors.lastname: Homayoun
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Sadeghi
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ; Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Seghatoleslam
authors.affiliation: Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Hosseini
authors.affiliation: Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran ; Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Ebrahimzadeh Bideskan
keywords: Apoptosis; Coriandrum sativum; Damage; Hippocampus; Neuronal; Seizure