title: [Genetic obesity: new diagnostic options].
abstract: - Obesity is an important risk factor for morbidity and premature death, as well as a contributing factor to psychosocial problems. The incidence of obesity has increased dramatically over the last few decades.- Obesity is considered to be a multifactorial condition in which both environmental factors and genetic factors play a part.- In approximately 5% of patients with morbid obesity, a monogenic cause can be identified. Mutations in the MC4R gene are the most frequently occurring monogenic cause of obesity.- The department of Genetics at the VU University Medical Center Amsterdam offers morbidly obese patients a diagnostic analysis of 50 obesity-associated genes. - An underlying obesity-associated genetic defect can influence patient response to certain treatments. Therefore, if the gene defect is known, it can be taken into account when considering treatment options.- The understanding of the genetics of obesity will significantly contribute to research into the development of personalized treatment options.
authors.affiliation: UMC Utrecht, afd. Medische Genetica, Utrecht.
authors.forename: T I
authors.initials: TI
authors.lastname: de Vries
authors.forename: S I M
authors.initials: SI
authors.lastname: Alsters
authors.forename: L
authors.initials: L
authors.lastname: Kleinendorst
authors.forename: G
authors.initials: G
authors.lastname: van Haaften
authors.forename: B
authors.initials: B
authors.lastname: van der Zwaag
authors.forename: M M
authors.initials: MM
authors.lastname: Van Haelst
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D009767:Obesity, Morbid / Q000235:genetics*; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D012307:Risk Factors
chemical_list: D044105:Receptor, Melanocortin, Type 4