title: Immediate loading for implant restoration compared with early or conventional loading: A meta-analysis.
abstract: OBJECTIVE
  This meta-analysis was to further confirm the no inferiority of immediate loading in clinical and radiographic outcomes compared with non-immediate loadings (early or conventional loading).
  
  
  METHODS
  Literature search on Pubmed and Embase was performed up to August 2015. The overall risk radios (RRs) and standard mean differences (SMDs) as well as their 95% confidence intervals (CI) were calculated for comparison.
  
  
  RESULTS
  Total 29 RCT with 1342 implants receiving immediate loading and 1279 implants receiving non-immediate loadings were included in this meta-analysis. Results indicated that there was no significant difference between immediate and non-immediate loadings in implant failure rate based on patients (RR = 1.45, 95% CI: 0.79 to 2.68) and implants (RR = 1.38, 95% CI: 0.86 to 2.21), MBL (SMD = -0.11, 95% CI: -0.39 to 0.17), and ISQ (SMD = -0.26, 95% CI: -0.53 to 0.01). Meanwhile, immediate loading showed significantly less MBL change than non-immediate loading. In addition, subgroup analyses showed that the immediate loading indicated slightly higher implant failure rate and lower ISQ than conventional loading.
  
  
  CONCLUSIONS
  Although overall analysis confirmed no inferiority of immediate loading compared with non-immediate loadings, the technique still need to be explored for improving implant success and stability during immediate loading based on the results in subgroup analyses.
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Shan Xi, Xi'an 710032, PR China.
authors.forename: Sijia
authors.initials: S
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Shan Xi, Xi'an 710032, PR China.
authors.forename: Shuyan
authors.initials: S
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Shan Xi, Xi'an 710032, PR China. Electronic address: jinglijinglijjj@163.com.
authors.forename: Yingliang
authors.initials: Y
authors.lastname: Song
mesh_terms: D003758:Dental Implantation, Endosseous / Q000379:methods; D019232:Dental Restoration Failure; D006801:Humans; D057893:Immediate Dental Implant Loading / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors
keywords: Conventional loading; Early loading; Immediate loading; Implant placement; Meta-analysis