title: Lung Cancer in Never-Smoking Women: A Sub-Analysis of the Spanish Female-Specific Database WORLD07.
abstract: The WORLD07 study characterizes lung cancer in Spanish women. This analysis investigated lung cancer features in never-smoking women. Of 2072 women recruited, 2035 were analyzed. Patient characteristics and demographics were similar for current/former smokers and never smokers. Among never smokers, 38.3% were exposed to passive smoking. Non-small-cell lung cancer was the most common type (78.8% of current/former smokers and 96.1% of never smokers) and adenocarcinoma the most common histology (69.1% and 83.4% respectively). There was a high incidence of lung cancer in Spanish never-smoking women and a high proportion (about 50%) had mutant epidermal growth factor receptor.
authors.affiliation: a Hospital Clínic , Barcelona , Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Viñolas
authors.affiliation: b Hospital Universitario Ramón y Cajal , Madrid , Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Garrido
authors.affiliation: c Hospital Clínico Lozano Blesa , Zaragoza , Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Isla
authors.affiliation: d Hospital Universitario Puerta de Hierro Majadahonda , Madrid , Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Provencio
authors.affiliation: e Hospital Sant Pau , Barcelona , Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Majem
authors.affiliation: f Hospital Miguel Servet , Zaragoza , Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Artal
authors.affiliation: g Hospital Germans Trias i Pujol , Barcelona , Spain.
authors.forename: Enric
authors.initials: E
authors.lastname: Carcereny
authors.affiliation: h Complejo Hospitalario Universitario A Coruña , Coruña , Spain.
authors.forename: Rosario
authors.initials: R
authors.lastname: Garcia Campelo
authors.affiliation: i Consorci Sanitari del Maresme, Hospital de Mataró , Barcelona , Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Lianes
authors.affiliation: j Hospital Provincial de Castellón , Castellón de la Plana , Spain.
authors.forename: Ramon
authors.initials: R
authors.lastname: De La Peñas
authors.affiliation: k Hospital Vall d'Hebron , Barcelona , Spain.
authors.forename: Enriqueta
authors.initials: E
authors.lastname: Felip
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D000077192:Adenocarcinoma of Lung; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D016208:Databases, Factual; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D011446:Prospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014408:Biomarkers, Tumor; D014028:Tobacco Smoke Pollution; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: Lung cancer; Spanish women; never smokers; prognostic factors; smoking