title: The duality of macrophage function in chronic lymphocytic leukaemia.
abstract: Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia and, in some patients, is accompanied by resistance to both chemotherapeutics and immunotherapeutics. In this review we will discuss the role of tumour associated macrophages (TAMs) in promoting CLL cell survival and resistance to immunotherapeutics. In addition, we will discuss mechanisms by which TAMs suppress T-cell mediated antitumour responses. Thus, targeting macrophages could be used to i) reduce the leukaemic burden via the induction of T-cell-mediated antitumour responses, ii) to reduce pro-survival signalling and enhance response to conventional chemotherapeutics or iii) enhance the response to therapeutic antibodies in current clinical use.
authors.affiliation: University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia.
authors.forename: Y C E
authors.initials: YCE
authors.lastname: Chen
authors.affiliation: Department of Haematology, Division of Cancer Services, Princess Alexandra Hospital, Brisbane, Qld, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Mapp
authors.affiliation: University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Blumenthal
authors.affiliation: University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia; Department of Haematology, Division of Cancer Services, Princess Alexandra Hospital, Brisbane, Qld, Australia.
authors.forename: M L
authors.initials: ML
authors.lastname: Burgess
authors.affiliation: University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Mazzieri
authors.affiliation: University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia.
authors.forename: S R
authors.initials: SR
authors.lastname: Mattarollo
authors.affiliation: Department of Haematology, Division of Cancer Services, Princess Alexandra Hospital, Brisbane, Qld, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Mollee
authors.affiliation: University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia; Department of Haematology, Division of Cancer Services, Princess Alexandra Hospital, Brisbane, Qld, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Gill
authors.affiliation: University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Qld, Australia. Electronic address: nsaunders@uq.edu.au.
authors.forename: N A
authors.initials: NA
authors.lastname: Saunders
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology