title: The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A Systematic Review and Meta-Analysis.
abstract: The modified Simiao decoctions (MSD) have been wildly applied in the treatment of gouty arthritis in China. However, the evidence needs to be evaluated by a systematic review and meta-analysis. After filtering, twenty-four randomised, controlled trials (RCTs) comparing the effects of MSD and anti-inflammation medications and/or urate-lowering therapies in patients with gouty arthritis were included. In comparison with anti-inflammation medications, urate-lowering therapies, or coadministration of anti-inflammation medications and urate-lowering therapies, MSD monotherapy significantly lowered serum uric acid (p< 0.00001, mean difference = -90.62, and 95% CI [-128.38, -52.86];p< 0.00001, mean difference = -91.43, and 95% CI [-122.38, -60.49];p= 0.02, mean difference = -40.30, and 95% CI [-74.24, -6.36], resp.). Compared with anti-inflammation medications and/or urate-lowering therapies, MSD monotherapy significantly decreased ESR (p< 0.00001; mean difference = -8.11; 95% CI [-12.53, -3.69]) and CRP (p= 0.03; mean difference = -3.21; 95% CI [-6.07, -0.36]). Additionally, the adverse effects (AEs) of MSD were fewer (p< 0.00001; OR = 0.08; 95% CI [0.05, 0.16]). MSD are effective in the treatment of gouty arthritis through anti-inflammation and lowering urate. However, the efficacy of MSD should be estimated with more RCTs.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, Henan 450052, China.
authors.forename: Ya-Fei
authors.identifier: 0000-0002-4141-5259
authors.initials: YF
authors.lastname: Liu
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Hubei University of Chinese Medicine, 1 Huangjiahu West Road, Wuhan, Hubei 430065, China.
authors.forename: Cai-Yu-Zhu
authors.initials: CY
authors.lastname: Wen
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, Henan 450052, China.
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, Henan 450052, China.
authors.forename: Guo-Lan
authors.initials: GL
authors.lastname: Xing
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
authors.forename: Sheng-Hao
authors.identifier: 0000-0001-8530-270X
authors.initials: SH
authors.lastname: Tu
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Chen