title: Familial Atrial Myxoma: Three Related Cases at an Australian Tertiary Institution.
abstract: Carney complex accounts for up to two-thirds of familial cardiac myxoma. It is a rare autosomal dominant syndrome, which is also characterized by multiple mucocutaneous lesions and endocrine tumors. We report on three first-degree relatives who underwent surgical resection at the same Australian tertiary institution. One patient re-presented with a recurrent tumor at an interval of 6 years. In this context, the role of interval surveillance, family screening, and genetic testing is explored. We recommend interval echocardiographic surveillance for affected individuals and first-degree relatives given the high risk of recurrence and the morbidity and mortality associated with cardiac tumors in any location.
authors.affiliation: Department of Cardiothoracic Surgery, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Campbell
authors.initials: C
authors.lastname: Schmidt
authors.affiliation: Department of Cardiothoracic Surgery, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Atsuo
authors.initials: A
authors.lastname: Doi
authors.affiliation: Department of Cardiothoracic Surgery, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Masashi
authors.initials: M
authors.lastname: Ura
authors.affiliation: Department of Cardiothoracic Surgery, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Chris
authors.initials: C
authors.lastname: Cole
authors.affiliation: Department of Cardiothoracic Surgery, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Julie
authors.initials: J
authors.lastname: Mundy
mesh_terms: D000328:Adult; D000368:Aged; D056733:Carney Complex / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D004452:Echocardiography; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006325:Heart Atria / Q000601:surgery; D006338:Heart Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D040941:Heredity; D006801:Humans; D008297:Male; D009232:Myxoma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D010375:Pedigree; D010641:Phenotype; D011793:Queensland; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Carney complex; atrial myxoma; cardiac myxoma; familial cardiac myxoma