title: Thiolysis of NBD-based dyes for colorimetric and fluorescence detection of H2S and biothiols: design and biological applications.
abstract: Hydrogen sulfide (H2S) is an important endogenous signaling molecule with multiple biological functions. The development of colorimetric and fluorescent probes for the visualization of H2S is useful for studying H2S biology. This review details up-to-date research on H2S probes based on thiolysis reactions of NBD (7-nitro-1,2,3-benzoxadiazole) amines or ethers (thioethers). The reactivity and selectivity of NBD-based dyes are discussed. The design principles of NBD-based probes are highlighted. The advantages and disadvantages of NBD-based probes are compared, and their biological applications are discussed.
authors.affiliation: State Key Laboratory of Organic-Inorganic Composites and Beijing Key Laboratory of Energy Environmental Catalysis, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang District, Beijing 100029, China. yilong@mail.buct.edu.cn.
authors.forename: Long
authors.initials: L
authors.lastname: Yi
authors.forename: Zhen
authors.initials: Z
authors.lastname: Xi
mesh_terms: D003124:Colorimetry / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006862:Hydrogen Sulfide / Q000032:analysis* / Q000737:chemistry; D010069:Oxadiazoles / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry
chemical_list: C542965:7-nitrobenzoxadiazole; D005456:Fluorescent Dyes; D010069:Oxadiazoles; D013438:Sulfhydryl Compounds; D006862:Hydrogen Sulfide