title: Defining New Colorectal Cancer Syndromes in a Population-based Cohort of the Disease.
abstract: Most known cancer syndromes confer an increased risk of more than one tumour types, and families with more than one colorectal cancer often segregate other cancers as well. The aim of this study was to examine if there is a general increased risk of other cancers in colorectal cancer families, which are defined as having two or more cases of colorectal cancer in close relatives.
  
  
  
  The study used a detailed family history of cancer diagnoses in a cohort of more than 3,000 consecutive colorectal cancer cases. A comparison was made between families with sporadic and those with familial colorectal cancer cases. Detailed morphology data were used to find further support for putative syndromes.
  
  
  
  There were significantly more non-colorectal cancers in the family history of the familial CRC cases (p<0.001), with significantly more gastric cancers (p<0.001), prostate cancers (p<0.001), urinary bladder cancers (p<0.001) and melanomas (p=0.002), leukaemia/lymphomas (p=0.004), gynaecological cancers (p=0.007) and breast cancers (p=0.023). There was also some support for different morphological profiles for four of the five tested syndromes.
  
  
  
  This study found support for a general increased risk of one or more different cancer syndromes involving families with colorectal cancer and other cancers. Further studies will define the different possible syndromes and determine the genetic background.
authors.affiliation: Karolinska Institutet, Department of Medicine Solna, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Forsberg
authors.affiliation: Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Anne
authors.initials: A
authors.lastname: Keränen
authors.affiliation: Karolinska Institutet, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Susanna
authors.initials: S
authors.lastname: VON Holst
authors.affiliation: Karolinska Institutet, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Simone
authors.initials: S
authors.lastname: Picelli
authors.affiliation: Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Nikos
authors.initials: N
authors.lastname: Papadogiannakis
authors.affiliation: Karolinska Institutet, Department of Laboratory Medicine, Division of Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Sam
authors.initials: S
authors.lastname: Ghazi
authors.affiliation: Karolinska Institutet, Department of Medicine Solna, Karolinska University Hospital, Stockholm, Sweden annika.lindblom@ki.se.
authors.forename: Annika
authors.initials: A
authors.lastname: Lindblom
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D013577:Syndrome
keywords: Colorectal cancer; familial; prevention; syndrome