title: The role of imaging in the diagnosis of primary prostate cancer.
abstract: Ultrasound and magnetic resonance imaging (MRI) are key imaging modalities in prostate cancer diagnosis. MRI offers a range of intrinsic contrast mechanisms (T2, diffusion-weighted imaging (DWI), MR spectroscopy (MRS)) and extrinsic contrast-generating options based on tumour vascular state following injection of weakly paramagnetic agents such as gadolinium. Together these parameters are referred to as multiparametric (mp)MRI and are used for detecting and guiding biopsy and staging prostate cancer. Although sensitivity of mpMRI is <75% for disease detection, specificity is >90% and a standardised reporting system together with MR-guided targeted biopsy is the optimal diagnostic pathway. Shear wave ultrasound elastography is a new technique which also holds promise for future studies. This article describes the developments in imaging the primary site of prostate cancer and reviews their current and future utility for screening, diagnosis and T-staging the disease.
authors.affiliation: Cancer Imaging Centre, The Institute of Cancer Research, UK.
authors.forename: Hugh
authors.initials: H
authors.lastname: Harvey
authors.affiliation: Cancer Imaging Centre, The Institute of Cancer Research, UK.
authors.forename: Nandita M
authors.initials: NM
authors.lastname: deSouza
keywords: MR guidance; MRI; Prostate cancer; biopsy; contrast-enhanced; diffusion; elastography; spectroscopy; ultrasound