title: Effect of Roux-en-Y gastric bypass on carotid intima-media thickness in Chinese obese patients with type 2 diabetes.
abstract: BACKGROUND
  The effect of Roux-en-Y gastric bypass (RYGB) on carotid intima-media thickness (C-IMT) in obese patients with type 2 diabetes (T2D) has not been well studied.
  
  
  OBJECTIVE
  To investigate the effect of RYGB on C-IMT and the relationship between C-IMT and some cardiovascular risk factors 12 months after surgery on Chinese obese patients with T2D.
  
  
  METHODS
  University hospital, China.
  
  
  METHODS
  Thirty-three consecutive obese patients with T2D and 18 healthy volunteers matched in age and sex were enrolled in this retrospective study. The anthropometric data, metabolism variables, and C-IMT were recorded before and 12 months after RYGB.
  
  
  RESULTS
  The patient group had significantly higher C-IMT than the control group before surgery (589.5±96.9 μm versus 457.9±48.6 μm, respectively; P<.01). C-IMT had significant positive relationships with age, body mass index, systolic blood pressure, visceral fat area (VFA), and serum leptin (r = .56, .44, .38, .42, and .38, respectively; P<.01). Twelve months after RYGB, the anthropometric data, metabolism variables, and C-IMT had improved signiﬁcantly. The change in C-IMT was positively correlated with changes in VFA and leptin level (r = .39 and .36, respectively; P<.01).
  
  
  CONCLUSIONS
  RYGB surgery seems to be effective on C-IMT for obese patients with T2D in China. VFA and leptin level are related to improvement of C-IMT.
authors.affiliation: Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Afﬁliated Sixth People's Hospital, Shanghai, China.
authors.forename: Haoyong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Afﬁliated Sixth People's Hospital, Shanghai, China. Electronic address: byq522@163.com.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China. Electronic address: chen1978910@163.com.
authors.forename: Lixin
authors.initials: L
authors.lastname: Jiang
mesh_terms: D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000208:ethnology / Q000601:surgery*; D012189:Retrospective Studies
keywords: Diabetes mellitus; Gastric bypass; Intima-media thickness; Obesity