title: IκB-α: At the crossroad between oncogenic and tumor-suppressive signals.
abstract: Nuclear factor κB (NF-κB) is an essential component of tumorigenesis and resistance to cancer treatments. NFKB inhibitor α (IκB-α) acts as a negative regulator of the classical NF-κB pathway through its ability to maintain the presence of NF-κB in the cytoplasm. However, IκB-α is also able to form a complex with tumor protein p53, promoting its inactivation. Recently, we demonstrated that IκB-α is able to mediate p53 nuclear exclusion and inactivation in chronic myeloid leukemia, indicating that IκB-α can modulate either oncogenic or tumor-suppressive functions, with important implications for cancer treatment. The present review describes the role of IκB-α in cancer pathogenesis, with particular attention to hematological cancers, and highlights the involvement of IκB-α in the regulation of p53 tumor-suppressive functions.
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Turin, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Morotti
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Turin, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Crivellaro
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Turin, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Panuzzo
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Turin, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Carrà
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Turin, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Guerrasio
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Turin, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Saglio
keywords: IκB-α; NF-κB; NFKB inhibitor α; chronic myeloid leukemia; p53