title: The Potential of Systems Biology to Discover Antibacterial Mechanisms of Plant Phenolics.
abstract: Drug resistance of bacterial pathogens is a growing problem that can be addressed through the discovery of compounds with novel mechanisms of antibacterial activity. Natural products, including plant phenolic compounds, are one source of diverse chemical structures that could inhibit bacteria through novel mechanisms. However, evaluating novel antibacterial mechanisms of action can be difficult and is uncommon in assessments of plant phenolic compounds. With systems biology approaches, though, antibacterial mechanisms can be assessed without the bias of target-directed bioassays to enable the discovery of novel mechanism(s) of action against drug resistant microorganisms. This review article summarizes the current knowledge of antibacterial mechanisms of action of plant phenolic compounds and discusses relevant methodology.
authors.affiliation: College of Arts and Sciences, Graduate School of Genome Science and Technology, University of Tennessee Knoxville, TN, USA.
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Rempe
authors.affiliation: Department of Food Science, University of TennesseeKnoxville, TN, USA; Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State UniversityRaleigh, NC, USA.
authors.forename: Kellie P
authors.initials: KP
authors.lastname: Burris
authors.affiliation: Department of Food Science, University of TennesseeKnoxville, TN, USA; Department of Mechanical, Aerospace, and Biomedical Engineering, University of TennesseeKnoxville, TN, USA.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Lenaghan
authors.affiliation: College of Arts and Sciences, Graduate School of Genome Science and Technology, University of TennesseeKnoxville, TN, USA; Department of Plant Sciences, University of TennesseeKnoxville, TN, USA.
authors.forename: C Neal
authors.initials: CN
authors.lastname: Stewart
keywords: antimicrobials; mechanism of action; membrane; metabolic processes; microbial structure