title: LAMP3 expression correlated with poor clinical outcome in human ovarian cancer.
abstract: Lysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy. Epithelial ovarian cancer is one of the most deadly global female gynecologic malignant tumors. Its clinical outcome is poor and most epithelial ovarian cancer patients tend to relapse because of drug resistance. However, lysosome-associated membrane protein 3 expression in epithelial ovarian cancer and its relationship between clinicopathologic factors remain poorly understood. To clarify the prognostic implications of lysosome-associated membrane protein 3 in epithelial ovarian cancer, we analyzed both messenger RNA and protein levels of lysosome-associated membrane protein 3 in ovarian carcinomas. Polymerase chain reaction results showed higher expression of lysosome-associated membrane protein 3 messenger RNA in epithelial ovarian cancer than in noncancerous tissues. Immunohistochemical results showed that high lysosome-associated membrane protein 3 cytoplasmic expression was significantly related to tumor grade ( p = 0.038), lymph node metastasis ( p = 0.049), metastasis ( p < 0.001), level of CA125 ( p = 0.030), and International Federation of Gynecology and Obstetrics (FIGO) ( p < 0.001). High lysosome-associated membrane protein 3 nuclear expression was significantly associated with tumor grade ( p = 0.046), tumor single or double (representative whether the tumor involving one or both ovaries) ( p = 0.016), metastasis ( p < 0.001), and FIGO stage ( p < 0.001). Survival analysis indicated that high lysosome-associated membrane protein 3 cytoplasmic expression (hazard ratio: 4.632, 95% confidence interval: 2.421-8.864; p < 0.001), patients' age (hazard ratio: 1.729, 95% confidence interval: 1.027-2.911; p = 0.039), and FIGO stage (hazard ratio: 2.049, 95% confidence interval: 1.113-3.774; p = 0.021) were significantly correlated with poor survival outcome of epithelial ovarian cancer patients.
authors.affiliation: 1 Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: 2 Department of Biology, Nantong University, Nantong, China.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Cao
authors.affiliation: 1 Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1 Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 3 Department of Pathology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Chan
authors.initials: C
authors.lastname: Yao
authors.affiliation: 4 Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Ge
authors.affiliation: 1 Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Yunzhao
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D051907:Lysosomal Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D016019:Survival Analysis; D059666:Lysosomal-Associated Membrane Protein 3
chemical_list: D051907:Lysosomal Membrane Proteins; D009363:Neoplasm Proteins; C114233:LAMP3 protein, human; D059666:Lysosomal-Associated Membrane Protein 3
keywords: Lysosome-associated membrane protein 3; epithelial ovarian cancer; gynecologic; malignancy; prognosis