title: Magnetic stimuli-responsive chitosan-based drug delivery biocomposite for multiple triggered release.
abstract: Stimuli-responsive biomaterials offer a unique advantage over traditional local drug delivery systems in that the drug elution rate can be controllably increased to combat developing symptomology or maintain high local elution levels for disease treatment. In this study, superparamagnetic Fe3O4nanoparticles and the antibiotic vancomycin were loaded into chitosan microbeads cross-linked with varying lengths of polyethylene glycol dimethacrylate. Beads were characterized using degradation, biocompatibility, and elution studies with successive magnetic stimulations at multiple field strengths and frequencies. Thirty-minute magnetic stimulation induced a temporary increase in daily elution rate of up to 45% that was dependent on field strength, field frequency and cross-linker length. Beads degraded by up to 70% after 3 days in accelerated lysozyme degradation tests, but continued to elute antibiotic for up to 8 days. No cytotoxic effects were observed in vitro compared to controls. These promising preliminary results indicate clinical potential for use in stimuli-controlled drug delivery.
authors.affiliation: Department of Biomedical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA. Electronic address: mhrris18@memphis.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Harris
authors.affiliation: Department of Biomedical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA.
authors.forename: Hamza
authors.initials: H
authors.lastname: Ahmed
authors.affiliation: Department of Biomedical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA.
authors.forename: Brandico
authors.initials: B
authors.lastname: Barr
authors.affiliation: Department of Biomedical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA.
authors.forename: David
authors.initials: D
authors.lastname: LeVine
authors.affiliation: Department of Biomedical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA.
authors.forename: Leslie
authors.initials: L
authors.lastname: Pace
authors.affiliation: Department of Electrical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA.
authors.forename: Ankita
authors.initials: A
authors.lastname: Mohapatra
authors.affiliation: Department of Electrical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA.
authors.forename: Bashir
authors.initials: B
authors.lastname: Morshed
authors.affiliation: Department of Biomedical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA.
authors.forename: Joel D
authors.initials: JD
authors.lastname: Bumgardner
authors.affiliation: Department of Biomedical Engineering, The University of Memphis, 3796 Norriswood Ave, Memphis TN, 38152, USA.
authors.forename: Jessica Amber
authors.initials: JA
authors.lastname: Jennings
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D065546:Drug Liberation; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D014640:Vancomycin / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D014640:Vancomycin; D048271:Chitosan
keywords: Drug delivery; Magnetic nanoparticles; Stimuli responsive biopolymer