title: Antioxidant and Antiproliferative Activities of an Ethylacetate Fraction of Picria Fel-Terrae Lour. Herbs
abstract: Background: Excessive production of oxygen free radicals and imbalance in the mechanisms responsible for
  antioxidant protection may result in the onset of many diseases including breast cancer. Objective: To evaluate
  antiproliferative and antioxidant activity of an ethylacetate fraction (EAF) of Picria fel-terrae Lour. Herbs in the T47D
  cell line. Methods: Phenolic and total flavonoid contents in EAF were determined. EAF was tested for cytotoxicity and
  effects on the cell cycle and apoptosis, as well as antioxidant activity. Results: EAF was found to contain high levels of
  phenolic agents (92.88 ± 0.50 mg GAE/g), total flavonoid (84.39 ± 0.07 mg QE/g). The EAF of Picria fel-terrae Lour.
  herbs was found to have an IC50 of 62.98μg/mL, caused accumulation in G0-G1 and S phase and increased early and
  late apoptosis. Antioxidant activity in DPPH assays gave an IC50 of 166.90 ± 0.10 μg/mL. Conclusions: The results
  reveal that EAF of Picria fel-terrae Lour. herbs has antiproliferative activity and strong antioxidant potential. Further
  studies are now needed to isolate the responsible antiproliferative and antioxidant components.
authors.affiliation: Department of Pharmaceutical Biology, University of Sumatera Utara, Medan, Indonesia. Email: dennysatria@usu.ac.id
authors.forename: Denny
authors.initials: D
authors.lastname: Satria
authors.forename: Jansen
authors.initials: J
authors.lastname: Silalahi
authors.forename: Ginda
authors.initials: G
authors.lastname: Haro
authors.forename: Syafruddin
authors.initials: S
authors.lastname: Ilyas
authors.forename: Poppy Anjelisa Z
authors.initials: PA
authors.lastname: Hsb
keywords: Antiproliferative; antioxidant; picria fel-terrae lour; ethylacetate fraction