title: Chemoembolization with Drug-eluting Microspheres Loaded with Doxorubicin for the Treatment of Cholangiocarcinoma.
abstract: To report clinical outcomes of transarterial chemoembolization (TACE) using drug-eluting beads (DEBs) loaded with doxorubicin for the treatment of unresectable intrahepatic cholangiocarcinoma (CCA).
  
  
  
  We treated 127 patients with doxorubicin via TACE. Inclusion criteria were: diagnosis of unresectable CCA; indication for TACE, performance status (PS) 0-2, >3 months of life expectancy, >18 years old, written consent. TACE was performed using DEBs for 109 (86%) patients and polythylene glycol drug-elutable microspheres (PEG) loaded with doxorubicin for 18 (14%) patients.
  
  
  
  Tumor response of the whole sample of 127 patients was partial response (PR) in 19 (15%) patients, stable disease (SD) in 101 (80%) and progressive disease (PD) in seven (5%) 3 months after therapy, with no complete responses. There were differences between type of embolics: PR was 7% and 77%, SD was 88% and 8%, and PD was 5% and 15%, and the disease control rate was 95% and 85% in the DEB and PEG groups, respectively. Most frequent side-effects were: abdominal pain, fever, nausea, and transaminase rise.
  
  
  
  TACE was effective and safe for CCA treatment, with a high disease control rate. The best response of PEG-TACE was PR, whereas it was SD for DEB-TACE.
authors.affiliation: Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC), Padua, Italy.
authors.forename: Camillo
authors.initials: C
authors.lastname: Aliberti
authors.affiliation: Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC), Padua, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Carandina
authors.affiliation: Oncology Unit, Agency Reunited Hospital of North Marche, Pesaro, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Sarti
authors.affiliation: Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC), Padua, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Pizzirani
authors.affiliation: Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC), Padua, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Ramondo
authors.affiliation: Diagnostics for Images Unit and Interventional Radiology, Agency Reunited Hospital of North Marche, Pesaro, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Mulazzani
authors.affiliation: Diagnostics for Images Unit and Interventional Radiology, Agency Reunited Hospital of North Marche, Pesaro, Italy.
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Mattioli
authors.affiliation: Oncology Unit, Agency Reunited Hospital of North Marche, Pesaro, Italy giammaria.fiorentini@ospedalimarchenord.it.
authors.forename: Giammaria
authors.initials: G
authors.lastname: Fiorentini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001650:Bile Duct Neoplasms / Q000473:pathology / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D018281:Cholangiocarcinoma / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin
keywords: Cholangiocarcinoma; chemoembolization; intra-arterial chemotherapy; safety; tumor response