title: Comparative analysis of primary and secondary glomerulopathies in the northeast of Brazil: data from the Pernambuco Registry of Glomerulopathies - REPEG.
abstract: BACKGROUND
  In Brazil, glomerulopathies are the third leading cause of chronic renal disease, accounting for 11% of dialysis patients. Studies on the prevalence of this disease in Northeastern Brazil are scarce.
  
  
  OBJECTIVE
  The aim was to describe the findings of biopsies and to conduct a comparative analysis on the clinical laboratory presentation of primary glomerulopathies (PG) and secondary glomerulopathies (SG).
  
  
  METHODS
  This was a retrospective study conducted at two public teaching hospitals in the state of Pernambuco, Northeastern Brazil.
  
  
  RESULTS
  A total of 1151 biopsies performed between 1998 and 2016 were analyzed. The sample consisted of 670 biopsies of native kidneys, after excluding extra glomerular diseases and unsuitable material. PG were more frequent than SG (58% vs. 42%). There was a prevalence among PG of focal segmental glomerulosclerosis (43%). Membranoproliferative glomerulonephritis and collapsing glomerulopathy, accounted for 9% and 3% of the PG, respectively. For SG, the main etiologies were lupus nephritis (67%) and infections (10%). Female sex, hematuria and an elevated level of creatinine were related to a greater chance of SG, at multivariate analysis. An increase of proteinuria reduced this chance. Nephrotic syndrome was more common among the PG, while urinary abnormalities and nephritic syndrome prevailed in patients with SG.
  
  
  CONCLUSIONS
  This is the first registry of glomerulopathies in Northeastern Brazil. It also presents a comparative analysis of the main clinical laboratory abnormalities of PG and SG, and includes the current classifications of glomerular diseases.
authors.affiliation: Universidade Federal de Pernambuco, Brazil.
authors.forename: Denise Maria do Nascimento
authors.initials: DM
authors.lastname: Costa
authors.affiliation: Universidade Federal de Pernambuco, Brazil.
authors.forename: Lucila Maria
authors.initials: LM
authors.lastname: Valente
authors.affiliation: Universidade Federal de Pernambuco, Brazil.
authors.forename: Pedro Alves da Cruz
authors.initials: PA
authors.lastname: Gouveia
authors.affiliation: Universidade Federal de Pernambuco, Brazil.
authors.forename: Filipe Wanick
authors.initials: FW
authors.lastname: Sarinho
authors.affiliation: Universidade Federal de Pernambuco, Brazil.
authors.forename: Gisele Vajgel
authors.initials: GV
authors.lastname: Fernandes
authors.affiliation: Universidade Federal de Pernambuco, Brazil.
authors.forename: Maria Alina Gomes de Mattos
authors.initials: MA
authors.lastname: Cavalcante
authors.affiliation: Universidade Federal de Pernambuco, Brazil.
authors.forename: Camila Barbosa Lyra de
authors.initials: CB
authors.lastname: Oliveira
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira, Brazil.
authors.forename: Carolina de Andrade Jordão de
authors.initials: CA
authors.lastname: Vasconcelos
authors.affiliation: Instituto de Medicina Integral Prof. Fernando Figueira, Brazil.
authors.forename: Emanuel Sávio Cavalcante
authors.initials: ES
authors.lastname: Sarinho
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D055815:Young Adult