title: Naphtoquinones and Sesquiterpene Cyclopentenones from the Sponge Smenospongia cerebriformis with Their Cytotoxic Activity.
abstract: Two new naphtoquinones (smenocerones A and B, 1 and 2) and four known sesquiterpene cyclopentenones (dactylospongenones A-D, 3-6) were isolated from sponge Smenospongia cerebriformis living in the Eastern Sea of Vietnam. Their chemical structures were determined by high resolution electrospray ionization (HR-ESI)-MS, NMR spectroscopic analysis, and in comparison with the reported data. The chiroptical properties of compounds 3-6 were examined by experiment and theoretical calculation of circular dichroism (CD) spectra to prove their absolute configurations. Compound 2 significantly exhibited cytotoxic activity towards lung carcinoma (LU-1), hepatocellular carcinoma (HepG-2), promyelocytic leukemia (HL-60), breast carcinoma (MCF-7), and melanoma (SK-Mel-2) human cancer cells with IC50values of 5.5±0.8, 3.2±0.2, 4.0±0.7, 4.1±0.8, and 5.7±1.1 µg/mL, respectively.
authors.affiliation: Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).|Hanoi University of Science, Vietnam National University.
authors.forename: Le Thi
authors.initials: LT
authors.lastname: Huyen
authors.affiliation: Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Dan Thi Thuy
authors.initials: DTT
authors.lastname: Hang
authors.affiliation: Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.affiliation: Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Pham Hai
authors.initials: PH
authors.lastname: Yen
authors.affiliation: Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Hoang Le Tuan
authors.initials: HLT
authors.lastname: Anh
authors.affiliation: Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Tran Hong
authors.initials: TH
authors.lastname: Quang
authors.affiliation: Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.affiliation: Hanoi University of Science, Vietnam National University.
authors.forename: Nguyen Van
authors.initials: NV
authors.lastname: Dau
authors.affiliation: Insitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST).
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D003517:Cyclopentanes / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*
chemical_list: D003517:Cyclopentanes; D009285:Naphthoquinones; C013905:cyclopentenone
keywords: Smenospongia cerebriformis; chiroptical property; cytotoxicity; dactylospongenone; smenocerone A; smenocerone B