title: [Dexmedetomidine improves function of lung oxygenation in patients with moderate chronic obstructive pulmonary disease underwent lung cancer surgery].
abstract: To determine whether dexmedetomidine (Dex) improves oxygenation and lung mechanics in patients with moderate chronic obstructive pulmonary disease (COPD) during lung cancer surgery.  Methods: Fifty-six patients with moderate COPD were randomly allocated to a control group and a Dex group (n=28 each). In the Dex group, dexmedetomidine was given as an initial loading dose at 1.0 μg/kg lasting for 10 min followed by a maintenance dose at 0.5 μg/(kg.h) during OLV while the control group was administered an equal volume of 0.9% saline accordingly.  Results: Patients in the Dex group had a significantly higher oxygenation index (P<0.05) and higher dynamic lung compliance at Dex-30 and Dex-60 (P<0.05) compared with those in the control group. In the Dex group, oxygenation index in the postoperative period was significantly higher (P= 0.025) and postoperative complications were lower than those in the control group.  Conclusion: Dex administration may provide clinically relevant benefits by improving o xygenation index and lung mechanics, and reducing postoperative pulmonary complications in patients with moderate COPD underwent lung cancer surgery.
authors.affiliation: Clinical Medical School of Soochow University, Suzhou Jiangsu 215006; Department of Anesthesiology, Affiliated Hospital of Jiangnan University (Wuxi No. 4 People's Hospital), Wuxi Jiangsu 214062, China.
authors.forename: Jiru
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Jiangnan University (Wuxi No. 4 People's Hospital), Wuxi Jiangsu 214062, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Dong
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Jiangnan University (Wuxi No. 4 People's Hospital), Wuxi Jiangsu 214062, China.
authors.forename: Hongdi
authors.initials: H
authors.lastname: Qian
authors.affiliation: Department of Anaesthesia and Intensive Care, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University; Department of Anesthesiology, Renji Hospital Affiliated of Shanghai Jiao Tong University School of Medicine, Shanghai 200438, China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Yu
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008175:Lung Neoplasms / Q000601:surgery*; D060046:Maintenance Chemotherapy; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000378:metabolism; D012123:Pulmonary Ventilation / Q000187:drug effects* / Q000502:physiology; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D020927:Dexmedetomidine