title: Apoptosis in Primary Hyperparathyroidism.
abstract: Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. This review paper presents the role of apoptosis in PHPT. The comparison of the expression of Fas, TRAIL, BCL-2 family members, p53 in MGD, PA, and PC, among others, was described. The expression of described factors varies among proliferative lesions of parathyroid gland; therefore, these could serve as additional markers to assist in the diagnosis.
authors.affiliation: a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
authors.forename: Oliwia Anna
authors.initials: OA
authors.lastname: Segiet
authors.affiliation: a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Mielańczyk
authors.affiliation: a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Piecuch
authors.affiliation: a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Michalski
authors.affiliation: b Department of General and Endocrine Surgery , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
authors.forename: Szczepan
authors.initials: S
authors.lastname: Tyczyński
authors.affiliation: a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
authors.forename: Marlena
authors.initials: M
authors.lastname: Brzozowa-Zasada
authors.affiliation: b Department of General and Endocrine Surgery , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Deska
authors.affiliation: a Department of Histology and Embryology , School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia , Katowice , Poland.
authors.forename: Romuald
authors.initials: R
authors.lastname: Wojnicz
mesh_terms: D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins / Q000032:analysis* / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis / Q000473:pathology*; D006965:Hyperplasia / Q000175:diagnosis / Q000473:pathology; D010280:Parathyroid Glands / Q000166:cytology / Q000473:pathology*; D010282:Parathyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers
keywords: apoptosis; parathyroid adenoma; parathyroid carcinoma; parathyroid hyperplasia; primary hyperparathyroidism