title: Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice.
abstract: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, which spontaneously exhibit obesity, diabetes, hyperlipidemia, and NASH with liver nodules.
  
  
  
  We examined the effects of coffee intake on various conditions of the metabolic syndrome using TSOD mice. The daily volume of coffee administered was limited so that it reflected the appropriate quantities consumed in humans. To clarify the effects of the specific components, animals were divided into two coffee-intake groups that included with and without caffeine.
  
  
  
  Coffee intake did not significantly affect obesity and hyperlipidemia in TSOD mice. In contrast, coffee intake caused various degrees of improvement in the pancreatic beta cell damage and steatohepatitis with liver carcinogenesis. Most of the effects were believed to be caused by a synergistic effect of caffeine with other components such as polyphenols. However, the antifibrotic effects of coffee appeared to be due to the polyphenols rather than the caffeine.
  
  
  
  A daily habit of drinking coffee could possibly play a role in the prevention of metabolic syndrome.
authors.affiliation: 1 Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima, Japan .
authors.forename: Syunsuke
authors.initials: S
authors.lastname: Watanabe
authors.affiliation: 2 Department of Anatomy and Cell Biology, Faculty of Pharmacy, Research Institute of Pharmaceutical Science, Musashino University , Nishitokyo, Japan .
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: 1 Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima, Japan .
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Ogawa
authors.affiliation: 1 Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima, Japan .
authors.forename: Hisanori
authors.initials: H
authors.lastname: Uehara
authors.affiliation: 1 Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima, Japan .
authors.forename: Takaaki
authors.initials: T
authors.lastname: Tsunematsu
authors.affiliation: 1 Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima, Japan .
authors.forename: Hayato
authors.initials: H
authors.lastname: Baba
authors.affiliation: 1 Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima, Japan .
authors.forename: Yuki
authors.initials: Y
authors.lastname: Morimoto
authors.affiliation: 1 Department of Pathology and Laboratory Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima, Japan .
authors.forename: Koichi
authors.initials: K
authors.lastname: Tsuneyama
mesh_terms: D000375:Aging; D000818:Animals; D002110:Caffeine / Q000627:therapeutic use; D003069:Coffee; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology / Q000517:prevention & control; D006949:Hyperlipidemias / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000473:pathology; D050152:Intra-Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology / Q000517:prevention & control; D008113:Liver Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy*; D051379:Mice; D008820:Mice, Obese; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use
chemical_list: D003069:Coffee; D010726:Phosphodiesterase Inhibitors; D002110:Caffeine
keywords: animal model; beta cell failure; coffee intake; hepatocellular carcinoma; nonalcoholic steatohepatitis