title: The genetic evolution of canine parvovirus - A new perspective.
abstract: To trace the evolution process of CPV-2, all of the VP2 gene sequences of CPV-2 and FPV (from 1978 to 2015) from GenBank were analyzed in this study. Then, several new ideas regarding CPV-2 evolution were presented. First, the VP2 amino acid 555 and 375 positions of CPV-2 were first ruled out as a universal mutation site in CPV-2a and amino acid 101 position of FPV feature I or T instead of only I in existing rule. Second, the recently confusing nomenclature of CPV-2 variants was substituted with a optional nomenclature that would serve future CPV-2 research. Third, After check the global distribution of variants, CPV-2a is the predominant variant in Asia and CPV-2c is the predominant variant in Europe and Latin America. Fourth, a series of CPV-2-like strains were identified and deduced to evolve from modified live vaccine strains. Finally, three single VP2 mutation (F267Y, Y324I, and T440A) strains were caught concern. Furthermore, these three new VP2 mutation strains may be responsible for vaccine failure, and the strains with VP2 440A may become the novel CPV sub-variant. In conclusion, a summary of all VP2 sequences provides a new perspective regarding CPV-2 evolution and the correlative biological studies needs to be further performed.
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Tianhe District, Guangzhou, Guangdong Province, People's Republic of China.|Key Laboratory of Comprehensive Prevention and Control for Severe Clinical Animal Diseases of Guangdong Province, Guangzhou, Guangdong Province, People's Republic of China.|Guangdong Engineering and Technological Research Center for Pets, Guangzhou, Guangdong Province, People's Republic of China.
authors.forename: Pei
authors.identifier: http://orcid.org/0000-0002-9560-2826
authors.initials: P
authors.lastname: Zhou
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Tianhe District, Guangzhou, Guangdong Province, People's Republic of China.|Key Laboratory of Comprehensive Prevention and Control for Severe Clinical Animal Diseases of Guangdong Province, Guangzhou, Guangdong Province, People's Republic of China.|Guangdong Engineering and Technological Research Center for Pets, Guangzhou, Guangdong Province, People's Republic of China.
authors.forename: Weijie
authors.initials: W
authors.lastname: Zeng
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Tianhe District, Guangzhou, Guangdong Province, People's Republic of China.|Key Laboratory of Comprehensive Prevention and Control for Severe Clinical Animal Diseases of Guangdong Province, Guangzhou, Guangdong Province, People's Republic of China.|Guangdong Engineering and Technological Research Center for Pets, Guangzhou, Guangdong Province, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Tianhe District, Guangzhou, Guangdong Province, People's Republic of China.|Key Laboratory of Comprehensive Prevention and Control for Severe Clinical Animal Diseases of Guangdong Province, Guangzhou, Guangdong Province, People's Republic of China.|Guangdong Engineering and Technological Research Center for Pets, Guangzhou, Guangdong Province, People's Republic of China.
authors.forename: Shoujun
authors.initials: S
authors.lastname: Li
mesh_terms: D000818:Animals; D001208:Asia; D036022:Capsid Proteins / Q000235:genetics; D004285:Dogs; D019143:Evolution, Molecular; D014644:Genetic Variation / Q000235:genetics; D009154:Mutation; D017993:Parvovirus, Canine / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D014764:Viral Proteins / Q000235:genetics
chemical_list: D036022:Capsid Proteins; D014764:Viral Proteins