title: Polymorphisms of RAD51B are associated with rheumatoid arthritis and erosion in rheumatoid arthritis patients.
abstract: Rheumatoid arthritis (RA) is a common, chronic autoimmune disease affecting 0.5-1.0% of adults worldwide, including approximately 4.5-5.0 million patients in China. The genetic etiology and pathogenesis of RA have not yet been fully elucidated. Recently, one new RA susceptibility gene (RAD51B) has been identified in Korean and European populations. In this study, we designed a two-stage case-control study to further assess the relationship of common variants in the RAD51B gene with increased risk of RA in a total of 965 RA patients and 2,511 unrelated healthy controls of Han Chinese ancestry. We successfully identified a common variant, rs911263, as being significantly associated with the disease status of RA (P = 4.8 × 10-5, OR = 0.64). In addition, this SNP was shown to be related to erosion, a clinical assessment of disease severity in RA (P = 2.89 × 10-5, OR = 0.52). These findings shed light on the role of RAD51B in the onset and severity of RA. More research in the future is needed to clarify the underlying functional link between rs911263 and the disease.
authors.affiliation: Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zhi
authors.affiliation: Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Yao
authors.affiliation: Department of Hip Injury and Disease, Orthopedic Hospital of Henan Province, Qiming South Road No.82, Luoyang, Henan, China.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Ma
authors.affiliation: Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
authors.forename: Weijie
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Hip Injury and Disease, Orthopedic Hospital of Henan Province, Qiming South Road No.82, Luoyang, Henan, China.
authors.forename: Honggan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
authors.forename: Jianbing
authors.initials: J
authors.lastname: Ma
mesh_terms: D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000473:pathology; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C413002:RAD51B protein, human