title: Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds.
abstract: Phytocompounds have been used in medicine for decades owing to their potential in anti-inflammatory applications. However, major difficulties in achieving sustained delivery of phyto-based drugs are related to their low solubility and cell penetration, and high instability. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in the pharmaceutical sector. This review focuses on the recent advances in nanocarrier-mediated drug delivery of bioactive molecules of plant origin in the field of anti-inflammatory research. In particular, special attention is paid to the relationship between structure and properties of the nanocarrier and phytodrug release behavior.
authors.affiliation: Institute of Agro-Environmental and Forest Biology (IBAF-CNR), Via Pietro Castellino 111, 80131 Napoli, Italy. raffaele.conte86@tiscali.it.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Conte
authors.affiliation: Institute for Polymers, Composites, and Biomaterials (IPCB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy. valentina.marturano@unina.it.|Department of Chemical Sciences, University of Naples "Federico II", Via Cynthia 4, 80125 Napoli, Italy. valentina.marturano@unina.it.
authors.forename: Valentina
authors.initials: V
authors.lastname: Marturano
authors.affiliation: Institute of Agro-Environmental and Forest Biology (IBAF-CNR), Via Pietro Castellino 111, 80131 Napoli, Italy. gianfranco.peluso@ibaf.cnr.it.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Peluso
authors.affiliation: Institute of Agro-Environmental and Forest Biology (IBAF-CNR), Via Pietro Castellino 111, 80131 Napoli, Italy. anna.calarco@ibaf.cnr.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Calarco
authors.affiliation: Institute for Polymers, Composites, and Biomaterials (IPCB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy. cerruti@ipcb.cnr.it.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Cerruti
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D064209:Phytochemicals / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility
chemical_list: D000893:Anti-Inflammatory Agents; D064209:Phytochemicals
keywords: cannabinoids; carbohydrates; essential oils; inflammation; nanocapsules; nanoparticles; nanosized delivery systems; phytochemicals; polyphenols; terpenoids