title: Response preparation and intra-individual reaction time variability in schizophrenia.
abstract: Background.It is important to prepare response in advance to increase the efficiency of its execution. The process of response preparation is usually studied using the precueing paradigm. In this paradigm subjects have to employ the preceding information about further imperative stimulus to perform proper response preparation, which shortens the reaction time of subsequent response execution. Previous studies detected the impairment of response preparation in schizophrenia only with the help of electroencephalographic parameters, but not with the assessing of reaction time. Therefore, in this study we attempted to find a behavioural parameter that could detect impairment in response preparation of schizophrenia patients. It was recently found that appropriate response preparation not only shortens the reaction time but also increases its stability, which is measured with the intra-individual reaction time variability. It was also revealed that response stability could better find cognitive dysfunction in some studies of schizophrenia disorder than classical behavioural parameters. Hence, the main goal of this study was to verify if intra-individual reaction time variability could detect the impairment of response preparation in schizophrenia patients.Materials and methods.In order to achieve the main purpose, we carried out a study with 14 schizophrenia patients and 14 control group subjects. We used precueing paradigm in our research, in which participants had to employ information about stimulus probability for the proper response preparation.Results.Our main result showed that despite the responses of schizophrenia patients were faster to the high-probability stimulus than to the low-probability one (F(1, 13) = 30.9,p< 0.001), intra-individual reaction time variability did not differ in this group between the responses to more and less probable stimuli (F(1, 13) = 0.64,p= 0.44).Conclusions.Results of the study suggest that people with schizophrenia were able to use precueing probabilistic information only to shorten their reaction time, but not to increase response stability. Therefore, it was found that intra-individual reaction time variability parameter could detect response preparation impairment in schizophrenia, and could be used in clinical purposes.
authors.affiliation: Department of Neurobiology and Biophysics, Vilnius University, Vilnius, Lithuania.
authors.forename: Denisas
authors.initials: D
authors.lastname: Dankinas
authors.affiliation: Department of Neurobiology and Biophysics, Vilnius University, Vilnius, Lithuania.
authors.forename: Sigita
authors.initials: S
authors.lastname: Mėlynytė
authors.affiliation: Republican Vilnius Psychiatric Hospital, Vilnius, Lithuania.|Psychiatric Clinic, Vilnius University, Vilnius, Lithuania.
authors.forename: Aldona
authors.initials: A
authors.lastname: Šiurkutė
authors.affiliation: Department of Neurobiology and Biophysics, Vilnius University, Vilnius, Lithuania.|Republican Vilnius Psychiatric Hospital, Vilnius, Lithuania.
authors.forename: Kastytis
authors.initials: K
authors.lastname: Dapšys
keywords: intra-individual reaction time variability; response preparation; response stability; schizophrenia