title: Report: Synthesis and screening of some new N-alkyl/aralkyl-N-(3,4- ethylenedioxybenzyl)-4-substituted benzenesulfonamides as potential antibacterial agents.
abstract: The various p-substituted benzenesulfonyl chlorides (2a-e) were treated with (3,4-methylenedioxy) benzylamine (1) in the presence of aqueous Na2CO3solution to synthesize N-(3,4-methylenedioxybenzyl)-4-substitutedbenzenesulfonamides (3a-e). The synthesized molecules were further converted into corresponding N-ethyl/benzyl/4-flourobenzyl-N-(3,4-methylenedioxybenzyl)-4-substitutedbenzenesulfonamides (7a-e, 8a-e, 9a-e) on reaction with ethyl iodide (4), benzyl chloride (5) and 4-flourobenzyl chloride (6) in the presence of sodium hydride using N,N-dimethylformamide as solvent. The structure elucidation was processed through different spectral techniques including IR,1H-NMR and EIMS. The screening of the synthesized molecules against Gram-bacterial strains, to evaluate antibacterial activity, showed them moderately good inhibitors as shown by their low MIC values.
authors.affiliation: Department of Chemistry, Government College University, Lahore. Pakistan.
authors.forename: Azizur
authors.initials: A
authors.lastname: Rehman
authors.affiliation: Department of Chemistry, Government College University, Lahore. Pakistan.
authors.forename: Asia
authors.initials: A
authors.lastname: Siddiqa
authors.affiliation: Department of Chemistry, Government College University, Lahore. Pakistan.
authors.forename: Muhammad Athar
authors.initials: MA
authors.lastname: Abbasi
authors.affiliation: Department of Chemistry, Government College University, Lahore. Pakistan.
authors.forename: Sabahat Zahra
authors.initials: SZ
authors.lastname: Siddiqui
authors.affiliation: Department of Chemistry, Government College University, Lahore. Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Rasool
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D066244:Proton Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000096926:Benzenesulfonamides
chemical_list: D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D000096926:Benzenesulfonamides