title: TEMPO-mediated oxidation of polysaccharides: An ongoing story.
abstract: The oxidation of natural polysaccharides by TEMPO has become by now an "old chemical reaction" which led to numerous studies mainly conducted on cellulose. This regioselective oxidation of primary alcohol groups of neutral polysaccharides has generated a new class of polyuronides not identified before in nature, even if the discovery of enzymes promoting an analogous oxidation has been more recently reported. Around the same time, the scientific community discovered the surprising biological and techno-functional properties of these anionic macromolecules with a high potential of application in numerous industrial fields. The objective of this review is to establish the state of the art of TEMPO chemistry applied to polysaccharide oxidation, its history, the resulting products, their applications and the associated modifying enzymes.
authors.affiliation: Université Clermont Auvergne, Université Blaise Pascal, Institut Pascal, BP 10448, F-63000, Clermont-Ferrand, France; CNRS, UMR 6602, IP, F-63178, Aubière, France. Electronic address: guillaume.pierre@uca.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Pierre
authors.affiliation: Department of Chemistry, Materials, and Chemical Engineering "G. Natta" and Local Unit INSTM, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133, Milano, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Punta
authors.affiliation: Université Clermont Auvergne, Université Blaise Pascal, Institut Pascal, BP 10448, F-63000, Clermont-Ferrand, France; CNRS, UMR 6602, IP, F-63178, Aubière, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Delattre
authors.affiliation: Department of Chemistry, Materials, and Chemical Engineering "G. Natta" and Local Unit INSTM, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133, Milano, Italy; Università degli Studi e-Campus, Via Isimbardi 10, 22060, Novedrate, Como, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Melone
authors.affiliation: Université Clermont Auvergne, Université Blaise Pascal, Institut Pascal, BP 10448, F-63000, Clermont-Ferrand, France; CNRS, UMR 6602, IP, F-63178, Aubière, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Dubessay
authors.affiliation: Department of Chemistry, Materials, and Chemical Engineering "G. Natta" and Local Unit INSTM, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133, Milano, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Fiorati
authors.affiliation: Department of Chemistry, Materials, and Chemical Engineering "G. Natta" and Local Unit INSTM, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133, Milano, Italy.
authors.forename: Nadia
authors.initials: N
authors.lastname: Pastori
authors.affiliation: Istituto di Chimica del Riconoscimento Molecolare, CNR, Via Mario Bianco 9, 20131, Milano, Italy.
authors.forename: Yves M
authors.initials: YM
authors.lastname: Galante
authors.affiliation: Université Clermont Auvergne, Université Blaise Pascal, Institut Pascal, BP 10448, F-63000, Clermont-Ferrand, France; CNRS, UMR 6602, IP, F-63178, Aubière, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Michaud
keywords: Laccase; Nanofibers; Polysaccharides; Selective C-6 oxidation; TEMPO; TEMPO-enzyme systems