title: Changes in the Structure of the Thymus under Conditions of Various Treatments for Experimental Mammary Tumor.
abstract: Morphological changes in the thymus of female Wistar rats with experimental mammary gland carcinomas were studied. After adjuvant therapy, the area of the cortical matter and density of parenchymal cells in the thymus decreased, while areas of the medulla, connective tissue, and content of immunoblasts and macrophages increased. In the thymuses of rats receiving exogenous DNA, morphological signs of activation of the lymphoid and epithelial components were found: areas of the cortex and medulla, glandular and connective tissue corresponded to the values in intact animals, the counts of lymphocytes in the central part of the cortical matter and of macrophages in all zones of the thymus increased, and lymphocyte migration from the thymus increased (in comparison with the chemotherapy group).
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. kazakoff_oleg@mail.ru.
authors.forename: O V
authors.initials: OV
authors.lastname: Kazakov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kabakov
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.|Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
authors.forename: A F
authors.initials: AF
authors.lastname: Poveshchenko
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Ishchenko
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.|Novosibirsk State Pedagogical University, Novosibirsk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Poveshchenko
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: D N
authors.initials: DN
authors.lastname: Strunkin
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Raiter
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Michurina
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Konenkov
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000628:therapy*; D008408:Mastectomy; D017208:Rats, Wistar; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents
keywords: double-stranded DNA; lymphocytes; mammary tumor; thymus