title: Infarct topography and functional outcomes.
abstract: Acute ischemic stroke represents a major cause of long-term adult disability. Accurate prognostication of post-stroke functional outcomes is invaluable in guiding patient care, targeting early rehabilitation efforts, selecting patients for clinical research, and conveying realistic expectations to families. The involvement of specific brain regions by acute ischemia can alter post-stroke recovery potential. Understanding the influences of infarct topography on neurologic outcomes holds significant promise in prognosis of functional recovery. In this review, we discuss the recent evidence of the contribution of infarct location to patient management decisions and functional outcomes after acute ischemic stroke.
authors.affiliation: 1 Harvard Medical School, Boston, MA, USA.|2 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Etherton
authors.affiliation: 1 Harvard Medical School, Boston, MA, USA.|2 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Rost
authors.affiliation: 1 Harvard Medical School, Boston, MA, USA.|3 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
authors.forename: Ona
authors.initials: O
authors.lastname: Wu
mesh_terms: D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology*; D006801:Humans; D059906:Neuroimaging / Q000379:methods; D011379:Prognosis; D020127:Recovery of Function; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology
keywords: Acute ischemic stroke; neuroimaging; outcomes; topography; voxel-based lesion symptom mapping