title: Serum Sclerostin Increases After Acute Physical Activity.
abstract: Physical activity has a major impact on bone density and on osteoporosis prevention. Sclerostin is produced by osteocytes and inhibits bone formation. The impact of exercise on sclerostin secretion has not been studied so far. This pilot study aimed to explore circulating sclerostin levels immediately after acute exercise. Healthy young women practicing physical activity less than 120 min per week were enrolled. The exercise was a 45-min, low-speed, treadmill running test. Blood samples were taken at rest before exercise and within 5 min after the end of exercise. We assessed serum creatinine, 25-OH vitamin D, alkaline phosphatase, C-telopeptide of type I collagen, bone-specific alkaline phosphatase, and sclerostin. Sclerostin stability at rest was also validated over the same period of time among women fulfilling the same inclusion criteria. The study included 23 participants (mean ± SD age: 22.9 ± 1.5 years) for the exercise test and 9 participants for the resting test (26.1 ± 3.1 years). There was no difference in body mass index between the two groups. Sclerostin increased after exercise in comparison to baseline (mean ± SEM: 410 ± 27 vs. 290 ± 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 ±5.5%. In the resting test, sclerostin remained stable (303 ± 20 vs. 294 ± 20 pg/mL, p = 0.76). There was a substantial increase in serum sclerostin in untrained healthy young women immediately after physical activity. These results suggest the existence of an acute release of systemic sclerostin in response to physical activity.
authors.affiliation: University of Lyon - INSERM UMR1033, 69003, Lyon, France.|Department of Rheumatology, Hospices Civils de Lyon, 69003, Lyon, France.
authors.forename: Marie-Eva
authors.initials: ME
authors.lastname: Pickering
authors.affiliation: Medical Intensive Care Unit, Hospices Civils de Lyon, 69003, Lyon, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Simon
authors.affiliation: University of Lyon - INSERM UMR1033, 69003, Lyon, France.|Department of Rheumatology, Hospices Civils de Lyon, 69003, Lyon, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Sornay-Rendu
authors.affiliation: Department of Biochemistry, Hospices Civils de Lyon, 69003, Lyon, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Chikh
authors.affiliation: Department of Biochemistry, Hospices Civils de Lyon, 69003, Lyon, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Carlier
authors.affiliation: Department of Rheumatology, Hospices Civils de Lyon, 69003, Lyon, France.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Raby
authors.affiliation: University of Lyon - INSERM UMR1033, 69003, Lyon, France.
authors.forename: Pawel
authors.initials: P
authors.lastname: Szulc
authors.affiliation: University of Lyon - INSERM UMR1033, 69003, Lyon, France. cyril.confavreux@inserm.fr.|Department of Rheumatology, Hospices Civils de Lyon, 69003, Lyon, France. cyril.confavreux@inserm.fr.|INSERM UMR 1033, Faculté RTH Laënnec, 8 rue Guillaume Paradin, 69372, Lyon Cedex 08, France. cyril.confavreux@inserm.fr.
authors.forename: Cyrille B
authors.initials: CB
authors.lastname: Confavreux
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D015519:Bone Density / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D001862:Bone Resorption / Q000517:prevention & control; D024042:Collagen Type I / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D010011:Osteocytes / Q000378:metabolism; D015663:Osteoporosis, Postmenopausal / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010865:Pilot Projects
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D024042:Collagen Type I; D005819:Genetic Markers; D010281:Parathyroid Hormone; C422903:SOST protein, human
keywords: Bone turnover markers; Physical exercise; Sclerostin; Young females