title: Obstetrical and perinatal complications of twin pregnancies: is there a link with the type of infertility treatment?
abstract: BACKGROUND
  The aim of this study was to compare the maternal and perinatal data from spontaneous twin pregnancies with twin pregnancies conceived via assisted reproductive technology, and to evaluate the outcomes depending on the type of treatment.
  
  
  METHODS
  A historical cohort of all twin live births between 1997 and 2014 was used to create two groups: spontaneous pregnancies and pregnancies after infertility treatment (ovulation induction, intrauterine insemination, in vitro fertilization, and intracytoplasmic sperm injection). The population characteristics and pregnancy, childbirth, and neonatal complications were compared, and the data were adjusted for age, parity, chorionicity, and the mother's body mass index to assess only the impact of the infertility treatments.
  
  
  RESULTS
  In total, 1580 twin pregnancies were included, with 575 requiring assisted conception. We did not observe any differences between the assisted conception pregnancies and the spontaneous twin pregnancies with regard to the obstetric and childbirth complications and neonatal outcomes. In addition, there were no statistically significant differences between the types of infertility treatment.
  
  
  CONCLUSIONS
  After adjusting for the maternal parameters and chorionicity, the twin pregnancies conceived via assisted reproductive technology were not at an increased risk of obstetric and neonatal complications. Moreover, the type of treatment did not alter the obstetric and neonatal complications. Therefore, the higher complication rate was related to the patient's medical specifics, rather than to the infertility treatment.
authors.affiliation: Department of Obstetrics, GemJDF Project, CHU Lille, Lille, France.
authors.forename: Sophie
authors.identifier: http://orcid.org/0000-0003-4640-4230
authors.initials: S
authors.lastname: Deltombe-Bodart
authors.affiliation: Department of Obstetrics, GemJDF Project, CHU Lille, Lille, France.|EA 4489 - Perinatal Health and Environment, University of Lille, Lille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Deruelle
authors.affiliation: Department of Biostatistics, EA 2694 - Public Health: Epidemiology and Healthcare Quality, CHU Lille, Lille, France.
authors.forename: Elodie
authors.identifier: http://orcid.org/0000-0003-4103-236X
authors.initials: E
authors.lastname: Drumez
authors.affiliation: Department of Obstetrics, GemJDF Project, CHU Lille, Lille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Cordiez
authors.affiliation: Department of Reproductive Medicine, CHU Lille, Lille, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Catteau-Jonard
authors.affiliation: Department of Obstetrics, GemJDF Project, CHU Lille, Lille, France.|EA 4489 - Perinatal Health and Environment, University of Lille, Lille, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Garabedian
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects*
keywords: Assisted reproductive technology; in vitro fertilization; infertility treatment; intracytoplasmic sperm injection; intrauterine insemination; ovulation induction; twin pregnancy