title: Age-Specific Characteristics of CO-Mediated Reaction of the Pial Arteries of Various Diameters in Rats.
abstract: First-fourth order pial branches of the median cerebral artery were studied by biomicroscopy in male Wistar rats aged 1 and 12 months. Irrespective of age, CO-mediated mechanisms are involved in the regulation of the basal tone of pial vessels of various diameters (more so of arteries with well-developed muscular tunic). Injection of hemin confirmed that endogenous production of CO maintained vasodilatation and this effect was most pronounced in large pial branches of young animals, while zinc protoporphyrin IX blocked this effect in all cases. On the other hand, zinc IX protoporphyrin did not modify NO-mediated reaction caused by injection of L-arginine, while hemin compensated (though not completely) vasoconstriction induced by NO synthase blocker L-NAME. In contrast to NO, the effect of CO on blood vessels was not so rapid and potent, but more lasting. Other targets for CO were arteries with well-developed muscular tunic, while targets for NO were small vessels. The vasomotor effects of both gas transmitters were more pronounced in young animals.
authors.affiliation: Department of Human Anatomy, Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Kotsyuba
authors.affiliation: Department of Human Anatomy, Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Chertok
authors.affiliation: Department of Human Anatomy, Pacific State Medical University, Ministry of Health of the Russian Federation, Vladivostok, Russia. chertokv@mail.ru.
authors.forename: A G
authors.initials: AG
authors.lastname: Chertok
mesh_terms: D000375:Aging; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D002248:Carbon Monoxide / Q000494:pharmacology / Q000502:physiology*; D002536:Cerebral Arteries / Q000187:drug effects / Q000502:physiology*; D006427:Hemin / Q000494:pharmacology; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D011524:Protoporphyrins / Q000494:pharmacology; D017208:Rats, Wistar; D015398:Signal Transduction; D014664:Vasodilation
chemical_list: D011524:Protoporphyrins; C017803:zinc protoporphyrin; D006427:Hemin; D002248:Carbon Monoxide; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester
keywords: age-specific characteristics; bloodflow regulation; carbon monoxide; pial arteries