title: Single Center Experience on Anatomy-and Histopathology-Based Gastric Cancer Molecular Classification.
abstract: We analyzed the clinical utility of molecular classification based on anatomical and histological background. The study was conducted on 457 patients treated for gastric cancer with additional information about microsatellite instability status. We divided the patients in three groups of molecular classification based on anatomical and histological background: proximal non-diffused, diffused, and distal non-diffused groups. These groups varied in terms of clinical and pathological factors as well as survival rates. The molecular classification based on anatomical and histological data seems to be a useful tool in a simple classification of gastric cancer.
authors.affiliation: a General Surgery and Surgical Oncology Department , University of Siena , Siena , Italy.
authors.forename: Karol
authors.initials: K
authors.lastname: Polom
authors.affiliation: a General Surgery and Surgical Oncology Department , University of Siena , Siena , Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Marrelli
authors.affiliation: b Department of Oncology, Medical Oncology Unit , San Donato Hospital , Arezzo , Italy.|c Department of Medical, Surgery and Health Sciences , University of Trieste , Piazza Ospitale, Trieste , Italy.
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Roviello
authors.affiliation: a General Surgery and Surgical Oncology Department , University of Siena , Siena , Italy.
authors.forename: Costantino
authors.initials: C
authors.lastname: Voglino
authors.affiliation: d Department of Pathology , Azienda Ospedaliera Universitaria Senese , Siena , Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Vindigni
authors.affiliation: c Department of Medical, Surgery and Health Sciences , University of Trieste , Piazza Ospitale, Trieste , Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Generali
authors.affiliation: a General Surgery and Surgical Oncology Department , University of Siena , Siena , Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Roviello
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D002454:Cell Differentiation; D053843:DNA Mismatch Repair; D016208:Databases, Factual; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007558:Italy; D053208:Kaplan-Meier Estimate; D008297:Male; D053842:Microsatellite Instability; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010641:Phenotype; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000145:classification / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor
keywords: Mismatch repair; microsatellite instability; personalized medicine