title: Ethylcellulose oleogels for lipophilic bioactive delivery - effect of oleogelation on in vitro bioaccessibility and stability of beta-carotene.
abstract: The in vitro lipolysis and β-carotene (BC) transfer from oil to aqueous phase of canola oil ethylcellulose (EC) oleogels were measured using a static monocompartmental model simulating oral, gastric, and duodenal digestive stages. The effects of EC oleogelation on gel in vitro digestibility were examined, using un-structured canola oil as a control. The physicochemical properties of oleogels containing BC were also measured. It was found that oleogels made with 10% 10 cP and 10% 20 cP did not differ significantly in their extent of lipolysis or BC transfer compared to canola oil; however 10% 45 cP and 15.5% 20 cP had a significantly lower extent of lipolysis and BC transfer compared to other formulations. The structure and mechanical strength of the oleogels were both determined to be factors affecting lipolysis and transfer. The presence of BC did not significantly affect the mechanical strength of the gels and EC oleogelation delayed BC degradation under accelerated storage conditions compared to a heated canola oil control. These findings could contribute to the development of new applications for EC oleogels, specifically for the effective delivery of lipophilic molecules.
authors.affiliation: Department of Food Science, University of Guelph, Guelph, Ontario, N1G2W1 Canada. amarango@uoguelph.ca.
authors.forename: Chloe M
authors.initials: CM
authors.lastname: O Sullivan
authors.forename: Maya
authors.initials: M
authors.lastname: Davidovich-Pinhas
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Wright
authors.forename: Shai
authors.initials: S
authors.lastname: Barbut
authors.forename: Alejandro G
authors.initials: AG
authors.lastname: Marangoni
mesh_terms: D001682:Biological Availability; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004063:Digestion; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D007700:Kinetics; D009930:Organic Chemicals / Q000737:chemistry; D019207:beta Carotene / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004337:Drug Carriers; D009930:Organic Chemicals; C016021:oleogels; D019207:beta Carotene; C013517:ethyl cellulose; D002482:Cellulose