title: The Effects of Sleep Deprivation on Dissociation and Profiles of Mood, and Its Association with Biochemical Changes.
abstract: BACKGROUND
  Sleep deprivation is a method, which has being used in order to comprehend the functions of sleep both in healthy individuals and for the patients of depression with in treatment, for a long time. The objective of our present study is to examine the relation between hormonal values, which are known for being related to the effects of these said changes determined in the mood, dissociation and thought suppression in healthy individuals after one night of sleep deprivation implementation.
  
  
  METHODS
  One night sleep deprivation was performed on a total of thirty-two healthy volunteers (16 males and 16 females) who were included in the study. Blood samples were taken from the individuals before and after sleep deprivation implementation in order to determine cortisol, dehydroepiandrosterone-sulfate (DHEA-S) and Thyroid Functions' Levels tests. In order to evaluate the effects of the sleep deprivation on moods, "White Bear Suppression Inventory (WBSI)" has been conducted, with an aim of evaluating thought suppression, "Profile of Mood States (POMS)", "Dissociative Experiences Scale (DES)" with a purpose of realizing any dissociation tendency.
  
  
  RESULTS
  On the individuals who have been implemented for sleep deprivation, a decrease on depression and vigor-activity sub-scales values was detected, and an increase was determined on fatigue sub-scales values of "POMS". While the values of DES were found to have been statistically increased after sleep deprivation, also a significant decrease was determined on WBSI values. Even if there hasn't been any significant statistical change determined on cortisol levels after sleep deprivation, yet there had been some significant changes detected on Thyroid Stimulating Hormone (TSH), fT3, fT4, and DHEA-S levels. Decrease in "POMS" depression sub-scale values and increase on fatigue sub-scale values were determined on the individuals whose sT4 levels were found to be increased significantly in statistic manner after the sleep deprivation.
  
  
  CONCLUSIONS
  According to the results of our study, sleep deprivation for one night was determined to cause decrease on depressive mood, increase on dissociative symptoms and to lower the tendency of suppressing the unwanted thoughts, consciously. The fact of being obtained lower depression values, on the individuals with the increased DHEA-S levels after the sleep deprivation meets with the information claiming that the high DHEA-S levels may be deemed as protectors against the negative effects of the stress.
authors.affiliation: Department of Psychiatry, Division of Neuro Science, Selçuk University Faculty of Medicine, Konya, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Selvi
authors.affiliation: Clinic of Psychiatry, Afşin State Hospital, Kahramanmaraş, Turkey.
authors.forename: Sultan
authors.initials: S
authors.lastname: Kiliç
authors.affiliation: Department of Psychiatry, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Aydin
authors.affiliation: Department of Psychiatry, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Güzel Özdemir
keywords: Sleep deprivation; biochemical changes; dissociation; mood