title: Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes.
abstract: Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate risk of developing diabetes type 1 and 2 after pregnancy, in addition to complications to the fetus. We investigated the association of the polymorphisms rs7799039 (LEP) and rs13266634 (SLC30A8) in a case-control study in Euro-Brazilians with gestational diabetes (GDM, N = 134) and healthy pregnant women (control, N = 180). Real-time PCR with fluorescent probes (TaqMan system) was applied to genotyping. All polymorphisms were in Hardy-Weinberg equilibrium. The minor allele frequencies, for healthy and GDM, respectively, for the A-allele (LEP gene rs7799039) were 40.3% (95%CI = 35-45%) vs 36.6% (95%CI = 31-42%), P = 0.345; and for the T-allele (SLC30A8 gene rs13266634) were 27.8% (95%CI = 23-32%) vs 23.5% (95%CI = 18-29%), P = 0.227. Genotype comparisons for both polymorphisms showed no significant difference (P > 0.05). The polymorphisms rs7799039 and rs13266634 were not associated with GDM in the population studied (P > 0.05). The minor allele frequencies for both polymorphisms were similar to those of other Caucasian populations.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
authors.forename: A
authors.initials: A
authors.lastname: Teleginski
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
authors.forename: M
authors.initials: M
authors.lastname: Welter
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, PR, Brasil.|Escola de Ciências da Vida, Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brasil.
authors.forename: H R
authors.initials: HR
authors.lastname: Frigeri
authors.affiliation: Serviço de Endocrinologia e Metabologia do Paraná, Hospital de Clínicas, Curitiba, PR, Brasil.
authors.forename: R R
authors.initials: RR
authors.lastname: Réa
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR, Brasil.
authors.forename: E M
authors.initials: EM
authors.lastname: Souza
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
authors.forename: D
authors.initials: D
authors.lastname: Alberton
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
authors.forename: F G M
authors.initials: FG
authors.lastname: Rego
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Paraná, Curitiba, PR, Brasil geraldopicheth@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Picheth
mesh_terms: D000328:Adult; D000483:Alleles; D001938:Brazil; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics* / Q000378:metabolism; D016640:Diabetes, Gestational / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020738:Leptin / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy
chemical_list: D002352:Carrier Proteins; D027682:Cation Transport Proteins; D020738:Leptin; C498299:SLC30A1 protein, human; C017800:zinc-binding protein