title: [Management of patients with bradykinin-mediated angioedema in oral and maxillofacial surgery].
abstract: Bradykinin-mediated angioedema (AE) is a rare disease characterized by recurrent cutaneous or mucosal angioedema. This hereditary or acquired disease is of rapid installation, non-pruritic, usually painless and can affect the face, lips, larynx, gastrointestinal tract or extremities. When the affected area involves the upper respiratory tract, laryngeal angioedema can lead to imminent death by asphyxia. This is the reason for the high mortality rate (30 %) in undiagnosed or improperly managed patients. High-risk situations in oral and maxillofacial surgery procedures should be identified preoperatively. Short-term prophylaxis must be carried-out prior to any procedure that may trigger an attack. A multi-site reference center (CREAK) has been created to help clinicians to manage this disease. This article reviews the pathophysiologic mechanisms, the clinical presentations, the possible treatments, the acute strategies for attacks and different prophylactic possibilities in oral and maxillofacial surgery.
authors.affiliation: Service d'odontologie, hôpital Saint-Julien, CHU de Rouen, 76031 Rouen, France; UDSL, université Lille Nord de France, 59000 Lille, France. Electronic address: justine.rohart04@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Rohart
authors.affiliation: Centre national de référence des angiœdèmes, CHU de Grenoble, 38043 Grenoble cedex 09, France; Centre de référence des angiœdèmes, clinique universitaire de médecine interne, CHU de Grenoble, 38043 Grenoble cedex 09, France; Unité Inserm 1036, CEA-Grenoble, université Grenoble-Alpes, 38054 Grenoble cedex 09, France.
authors.forename: L
authors.initials: L
authors.lastname: Bouillet
authors.affiliation: Service d'odontologie, hôpital Saint-Julien, CHU de Rouen, 76031 Rouen, France.
authors.forename: H
authors.initials: H
authors.lastname: Moizan
mesh_terms: D000799:Angioedema / Q000145:classification / Q000209:etiology* / Q000628:therapy*; D054179:Angioedemas, Hereditary / Q000150:complications / Q000628:therapy; D001237:Asphyxia / Q000209:etiology / Q000628:therapy; D001920:Bradykinin / Q000009:adverse effects*; D004935:Esophageal Diseases / Q000209:etiology / Q000628:therapy; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000628:therapy; D006801:Humans; D019647:Oral Surgical Procedures / Q000379:methods*
chemical_list: D001920:Bradykinin
keywords: Angioedema; Angiœdème; Bradykinin; Bradykinine; Chirurgie; Maxillo-faciale; Maxillofacial surgery; Oral; Orale