title: Role of local alendronate delivery on the osseointegration of implants: a systematic review and meta-analysis.
abstract: There is controversy regarding whether locally delivered alendronate enhances osseointegration. The aim of this systematic review was to assess the role of local alendronate delivery (topical, or as a coating on implant surfaces) in the osseointegration of implants. The focused question was, "Does the local delivery of alendronate affect osseointegration around implants?". To address this question, indexed databases were searched, without time or language restriction, up to and including January 2017. Various combinations of the following key words were used: "alendronate", "bisphosphonates", "osseointegration", and "topical administration". letters to the editor, historic reviews, commentaries, case series, and case reports were excluded. In total, 18 experimental studies were included: alendronate-coated implants were used in 13 of these studies and local delivery in five studies. The results of 11 of the studies showed that alendronate coating increased new bone formation, the bone volume fraction, or bone-to-implant contact (BIC) and biomechanical properties. Results from two studies in which alendronate was administered topically indicated impaired BIC and/or biomechanical fixation around implants. On experimental grounds, local alendronate delivery seems to promote osseointegration. From a clinical perspective, the results in animal models support phase 1 studies in healthy humans (without co-morbidities other than edentulism).
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, New York, USA. Electronic address: sergio_kellesarian@urmc.rochester.edu.
authors.forename: S V
authors.initials: SV
authors.lastname: Kellesarian
authors.affiliation: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: T
authors.initials: T
authors.lastname: Abduljabbar
authors.affiliation: Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: F
authors.initials: F
authors.lastname: Vohra
authors.affiliation: Department of General Dentistry, Faculty of Dentistry, Universidad Santa Maria, Caracas, Venezuela.
authors.forename: V R
authors.initials: VR
authors.lastname: Malignaggi
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, New York, USA.
authors.forename: H
authors.initials: H
authors.lastname: Malmstrom
authors.affiliation: Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe, University of Frankfurt, Frankfurt, Germany; Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, New York, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Romanos
authors.affiliation: Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, New York, USA.
authors.forename: F
authors.initials: F
authors.lastname: Javed
mesh_terms: D000287:Administration, Topical; D019386:Alendronate / Q000008:administration & dosage*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004164:Diphosphonates / Q000008:administration & dosage*; D006801:Humans; D016348:Osseointegration / Q000187:drug effects*
chemical_list: D015921:Dental Implants; D004164:Diphosphonates; D019386:Alendronate
keywords: alendronate; bisphosphonates; implants; osseointegration; topical administration