title: Reduced CA2-CA3 Hippocampal Subfield Volume Is Related to Depression and Normalized by l-DOPA in Newly Diagnosed Parkinson's Disease.
abstract: Hippocampal dysfunctions may play an important role in the non-motor aspects of Parkinson's disease (PD), including depressive and cognitive symptoms. Fine structural alterations of the hippocampus and their relationship with symptoms and medication effects are unknown in newly diagnosed PD. We measured the volume of hippocampal subfields in 35 drug-naïve, newly diagnosed PD patients without cognitive impairment and 30 matched healthy control individuals. Assessments were performed when the patients did not receive medications and after a 24-week period of l-DOPA treatment. We obtained a T1-weighted 3D magnetization-prepared rapid acquisition gradient echo image at each assessment. FreeSurfer v6.0 was used for image analysis. Results revealed a selectively decreased CA2-CA3 volume in non-medicated PD patients, which was normalized after the 24-week treatment period. Higher depressive symptoms were associated with smaller CA2-CA3 volumes. These results indicate that the CA2-CA3 subfield is structurally affected in the earliest stage of PD in the absence of cognitive impairment. This structural anomaly, normalized by l-DOPA, is related to depressive non-motor symptoms.
authors.affiliation: Department of Neurology, Nyírö Gyula Hospital, National Institute of Psychiatry and Addictions , Budapest , Hungary.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Györfi
authors.affiliation: National Institute for Medical Rehabilitation, Budapest, Hungary; Department of Neurology, Semmelweis University, Budapest, Hungary.
authors.forename: Helga
authors.initials: H
authors.lastname: Nagy
authors.affiliation: Department of Neurology, Nyírö Gyula Hospital, National Institute of Psychiatry and Addictions , Budapest , Hungary.
authors.forename: Magdolna
authors.initials: M
authors.lastname: Bokor
authors.affiliation: School of Social Sciences and Psychology, Western Sydney University, Sydney, NSW, Australia; Marcs Institute for Brain and Behavior, Western Sydney University, Sydney, NSW, Australia.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Moustafa
authors.affiliation: Sleep and Brain Plasticity Centre, Department of Neuroimaging, IOPPN, King's College and Imperial College London, London, UK; Sleep Disorders Centre, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: Ivana
authors.initials: I
authors.lastname: Rosenzweig
authors.affiliation: Faculty of Medicine, Department of Behavioral Sciences, University of Szeged , Szeged , Hungary.
authors.forename: Oguz
authors.initials: O
authors.lastname: Kelemen
authors.affiliation: Department of Neurology, Nyírö Gyula Hospital, National Institute of Psychiatry and Addictions, Budapest, Hungary; Department of Cognitive Science, Budapest University of Technology and Economics, Budapest, Hungary; Faculty of Medicine, Department of Physiology, University of Szeged, Szeged, Hungary.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Kéri
keywords: MRI; Parkinson’s disease; depression; hippocampus; l-DOPA