title: Detecting the Cognitive Prodrome of Dementia with Lewy Bodies: A Prospective Study of REM Sleep Behavior Disorder.
abstract: Long-term studies in REM sleep behavior disorder (RBD) have shown a high rate of conversion into synucleinopathies. We aimed to prospectively follow-up a large cohort of RBD patients to identify cognitive markers for early detection of prodromal dementia.
  
  
  
  Seventy-six idiopathic RBD patients underwent polysomnography and a complete neuropsychological and neurological assessment and were then followed for a mean of 3.6 years. Cognitive characteristics at baseline were compared between patients who remained disease-free and those who developed a synucleinopathy, and between those who developed dementia first and those who developed parkinsonism first. Receiver operating characteristic curves were calculated to assess the diagnostic value of cognitive tests for detecting prodromal dementia.
  
  
  
  At follow-up, 34 patients developed a neurodegenerative disease: 19 parkinsonism-first and 15 dementia-first. RBD patients who first developed dementia were impaired at baseline in all cognitive domains (attention/executive functions, learning/memory, and visuospatial) compared to patients who developed parkinsonism. Moreover, 93% of patients who first developed dementia had mild cognitive impairment at baseline compared to 42% of patients who developed parkinsonism. RBD patients who developed parkinsonism first were similar at baseline to disease-free RBD patients on cognition. In dementia-first patients, two cognitive tests assessing attention and executive functions (Stroop Color Word Test and Trail Making Test) reliably predicted dementia (area under the curve ≥0.85) compared to parkinsonism-first patients or controls.
  
  
  
  This study shows that cognitive tests assessing attention and executive functions strongly predict conversion to dementia in RBD patients, and may be useful endpoints to determine the effectiveness of interventions to prevent cognitive deterioration in RBD patients.
authors.affiliation: Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.|Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.
authors.forename: Daphné
authors.initials: D
authors.lastname: Génier Marchand
authors.affiliation: Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.|Department of Psychiatry, Université de Montréal, Montreal, Quebec, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Montplaisir
authors.affiliation: Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.|Department of Neurology, Montreal General Hospital, Montreal, Quebec, Canada.
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Postuma
authors.affiliation: Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.|Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.
authors.forename: Shady
authors.initials: S
authors.lastname: Rahayel
authors.affiliation: Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.|Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Gagnon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition; D060825:Cognitive Dysfunction / Q000150:complications / Q000175:diagnosis; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D008568:Memory; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000150:complications / Q000175:diagnosis; D017286:Polysomnography; D062706:Prodromal Symptoms; D011446:Prospective Studies; D020187:REM Sleep Behavior Disorder / Q000150:complications* / Q000503:physiopathology*
keywords: Parkinson’s disease; REM sleep behavior disorder; cognition; dementia with Lewy bodies; neuropsychological assessment.