title: TRPA1 contributed to the neuropathic pain induced by docetaxel treatment.
abstract: Peripheral mechanical neuropathic pain is a serious side effect of docetaxel chemotherapy for cancer. However, the underlying mechanism for this side effect is unknown. In the present study, we found that docetaxel treatment induced mechanical allodynia in rats. We further revealed that the transient receptor potential ankyrin subtype 1 protein (TRPA1) protein level is upregulated and the TRPA1 activator allyl isothiocyanate induced larger ion currents in the dorsal root ganglion neurons from the docetaxel treated rats. In addition, application the TRPA1 blocker Ap18 reversed the docetaxel-induced mechanical hypersensitivity. We suggest that the docetaxel-induced mechanical allodynia is mediated by upregulation of TRPA1 in dorsal root ganglion neurons.
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Kun
authors.identifier: http://orcid.org/0000-0003-1009-0794
authors.initials: K
authors.lastname: Huang
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Donglin
authors.initials: D
authors.lastname: Bian
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Qixi
authors.initials: Q
authors.lastname: Zhai
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Ningning
authors.initials: N
authors.lastname: Gao
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Ruiying
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D001522:Behavior, Animal / Q000187:drug effects*; D000077143:Docetaxel; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006930:Hyperalgesia / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D009437:Neuralgia / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels / Q000378:metabolism*; D043823:Taxoids / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels; D043823:Taxoids; C480976:Trpa1 protein, rat; D000077143:Docetaxel
keywords: TRPA1; docetaxel; mechanical allodynia; pain