title: Spermatogonial Stem Cell Transplantation to the Testis.
abstract: Spermatogonial stem cells (SSCs) are located in the basal region of the seminiferous tubules and provide a self-renewing reservoir from which progenitor spermatogonia arise and transiently amplify in number before transition to a differentiating state. SSC transplantation involves grafting mouse testicular cells into the seminiferous tubules of an aspermic recipient testis that is generated either by chemical (e.g., busulfan) treatment or genetic mutations.
authors.forename: Shaun
authors.initials: S
authors.lastname: Goodyear
authors.forename: Ralph
authors.initials: R
authors.lastname: Brinster
mesh_terms: D000072956:Adult Germline Stem Cells / Q000502:physiology*; D000818:Animals; D008297:Male; D051379:Mice; D033581:Stem Cell Transplantation / Q000379:methods*; D013737:Testis / Q000166:cytology*