title: The Effect of Geraniol on Liver Regeneration After Hepatectomy in Rats.
abstract: Geraniol is a monoterpenoid alcohol that has a hepatoprotective effect. We investigated the regenerative effects of geraniol in rats after a 70% partial hepatectomy (PH). Using Wistar albino rats, nine groups were created: Group I was the control group, while the remaining groups received a single intraperitoneal dose of saline, Silymarin, or geraniol after PH. A 70% PH was performed on all groups except for groups II and III. Blood serum samples were obtained for alanine amino transferase (ALT) analysis. Then liver tissues were harvested for histological and real-time polymerase chain reaction (PCR) analyses. Tumor necrosis factor-α (TNFα) and interleukin 6 (IL6) gene expression were examined 24 and 48 h after PH. ALT levels were found to be statistically significantly increased in all PH-treated groups. TNFα and IL6 gene expression levels were elevated in geraniol-treated groups. Histological evaluation revealed a hepatoprotective effect for geraniol-treated groups. Our results suggest that geraniol plays a significant role during liver regeneration, which involves the elevated expression of TNFα and IL6 48 h after PH.
authors.affiliation: Department of Biology, Faculty of Science, Eskisehir Osmangazi University, Eskisehir, Turkey mcanbek@ogu.edu.tr.
authors.forename: Mediha
authors.initials: M
authors.lastname: Canbek
authors.affiliation: Department of Biology, Faculty of Science, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Uyanoglu
authors.affiliation: Department of Computer Engineering, Faculty of Engineering and Architecture, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Canbek
authors.affiliation: Department of Biology, Faculty of Science, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Ceyhan
authors.affiliation: Department of Biology, Faculty of Science, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozen
authors.affiliation: Department of Biology, Faculty of Science, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Basak
authors.initials: B
authors.lastname: Durmus
authors.affiliation: Department of Biology, Faculty of Science, Eskisehir Osmangazi University, Eskisehir, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Turgak
mesh_terms: D000080462:Acyclic Monoterpenes; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015870:Gene Expression / Q000235:genetics; D006498:Hepatectomy / Q000379:methods*; D015850:Interleukin-6 / Q000235:genetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D020011:Protective Agents / Q000494:pharmacology; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012838:Silymarin / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D000080462:Acyclic Monoterpenes; D000975:Antioxidants; D015850:Interleukin-6; D020011:Protective Agents; D012838:Silymarin; D013729:Terpenes; D014409:Tumor Necrosis Factor-alpha; D000410:Alanine Transaminase; C007836:geraniol
keywords: ALT; IL6; RT-PCR; TNFα; monoterpenoid alcohol