title: EMP2 re-expression inhibits growth and enhances radiosensitivity in nasopharyngeal carcinoma.
abstract: Although radiation therapy is the primary treatment for nasopharyngeal carcinoma, radioresistance remains a major obstacle to successful treatment in many cases, and the exact underlying molecular mechanisms are still ill-defined. EMP2, epithelial membrane protein-2, was a recently identified potential oncogene involved in multiple biological processes including cell migration and cell proliferation. This study was to explore the potential relationship between EMP2 expression, nasopharyngeal carcinoma genesis, and radioresistance. EMP2 expression status in 98 nasopharyngeal carcinoma clinical samples was examined by immunohistochemical staining. As a result, most of the nasopharyngeal carcinoma tumor samples were weakly or negatively stained, while paired adjacent normal tissues were moderately or strongly stained. Moreover, patients with higher expression of EMP2 had significant longer survival times. EMP2 re-expression suppresses cell growth, induces S-phase cell cycle arrest, and promotes radiosensitivity and apoptosis in nasopharyngeal carcinoma cells. These results support that loss of EMP2 is common, and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma.
authors.affiliation: 1 Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.|2 Laboratory of Tumor Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Tang
authors.affiliation: 3 Department of oncology, FuLing Central Hospital, Chongqing, China.
authors.forename: Ru-Yan
authors.initials: RY
authors.lastname: Liu
authors.affiliation: 2 Laboratory of Tumor Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Zhou
authors.affiliation: 1 Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
authors.forename: Meng-Zhen
authors.initials: MZ
authors.lastname: Yuan
authors.affiliation: 2 Laboratory of Tumor Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Wu
authors.affiliation: 2 Laboratory of Tumor Biotherapy, Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: 1 Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: 1 Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
authors.forename: Jin-Yi
authors.initials: JY
authors.lastname: Lang
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics; D002277:Carcinoma; D059447:Cell Cycle Checkpoints / Q000235:genetics; D045744:Cell Line, Tumor / Q000187:drug effects; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics* / Q000528:radiation effects; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy*; D011836:Radiation Tolerance / Q000235:genetics*
chemical_list: C486403:EMP2 protein, human; D008562:Membrane Glycoproteins
keywords: EMP2; Nasopharyngeal carcinoma; radiation therapy