title: Complete remission through icotinib treatment in Non-small cell lung cancer epidermal growth factor receptor mutation patient with brain metastasis: A case report.
abstract: Brain metastasis (BM) has been universally recognized as a poor prognostic factor in non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown efficacy in treating BM with an EGFR mutation. This paper reports a case of BM patient with EGFR-mutated NSCLC. According to the findings, a complete remission (CR) of the BM was achieved by icotinib treatment without conducting a radiotherapy, which was followed by a resection of the primary lung cancer lesion and lymph nodes. After one-year follow-up, the disease progressed to liver metastasis and liver lesion biopsy showed a T790M mutation. The patient responded well to the combination treatment of AZD9291 and icotinib after the failure of transcatheter arterial chemoembolization (TACE). This case report suggests that icotinib has a sustainable anticancer response to BM and the combination with icotinib and AZD9291 is effective for liver metastasis with T790M.
authors.affiliation: Department of Thoracic Surgery, PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine, PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Ruimin
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Pathology, PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Zhouhuan
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of Thoracic Surgery, PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Naichao
authors.initials: N
authors.lastname: Liang
authors.affiliation: Department of Oral and Maxillofacial Surgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China , Tel.:+86 10 66875514, Fax:+86 10 67817113.
authors.forename: Ping
authors.initials: P
authors.lastname: Chang
keywords: Non-small cell lung cancer; brain metastases; epidermal growth factor receptor; tyrosine kinase inhibitor