title: MAMMARY GLAND ADENOCARCINOMA IN A MALE BORNEAN ORANGUTAN (PONGO PYGMAEUS).
abstract: An adult male Bornean orangutan ( Pongo pygmaeus ) was diagnosed with invasive, poorly differentiated grade 9/9 mammary gland adenocarcinoma from a subcutaneous mass that was surgically removed during a routine preventative health examination. The tumor was tested for estrogen and progesterone receptors, human epidermal growth factor receptor 2 (HER2), and HER2 fluorescence in situ hybridization (HER2 FISH). Whole blood was tested for breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) genes. The orangutan was treated orally with two common human breast cancer drugs; tamoxifen and anastrozole. The orangutan lived for 4.5 yr postdetection, dying from an unrelated cause. This is the first reported case of mammary gland adenocarcinoma in a male great ape.
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Carpenter
authors.forename: Erika K
authors.initials: EK
authors.lastname: Crook
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D000077384:Anastrozole; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D018420:Ape Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D009376:Neoplasms, Hormone-Dependent / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary; D009570:Nitriles / Q000627:therapeutic use; D011148:Pongo pygmaeus; D013629:Tamoxifen / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014230:Triazoles; D013629:Tamoxifen; D000077384:Anastrozole
keywords: Anastrozole; BRCA; Pongo pygmaeus; mammary gland adenocarcinoma; orangutan; tamoxifen