title: N-Heterocyclic carbene copper-catalyzed direct alkylation of terminal alkynes with non-activated alkyl triflates.
abstract: (NHC)-Cu-catalyzed C(sp)-C(sp3) bond formation has been successfully achieved under mild conditions. Nonactivated alkyl triflates, which could be easily derived from alcohols, were utilized as C-O electrophiles. Mechanistic studies suggested that copper acetylide was the active species. Scale-up reactions further demonstrated the practicality and efficiency of the developed strategy.
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China. liqunjin@zjut.edu.cn xinquan@zjut.edu.cn and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, the Chinese Academy of Sciences, Lanzhou 730000, P. R. China.
authors.forename: Liqun
authors.identifier: http://orcid.org/0000-0002-9518-7423
authors.initials: L
authors.lastname: Jin
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China. liqunjin@zjut.edu.cn xinquan@zjut.edu.cn.
authors.forename: Wangfang
authors.initials: W
authors.lastname: Hao
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China. liqunjin@zjut.edu.cn xinquan@zjut.edu.cn.
authors.forename: Jianeng
authors.initials: J
authors.lastname: Xu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China. liqunjin@zjut.edu.cn xinquan@zjut.edu.cn.
authors.forename: Nan
authors.initials: N
authors.lastname: Sun
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China. liqunjin@zjut.edu.cn xinquan@zjut.edu.cn.
authors.forename: Baoxiang
authors.initials: B
authors.lastname: Hu
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China. liqunjin@zjut.edu.cn xinquan@zjut.edu.cn.
authors.forename: Zhenlu
authors.identifier: http://orcid.org/0000-0002-3699-1198
authors.initials: Z
authors.lastname: Shen
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China. liqunjin@zjut.edu.cn xinquan@zjut.edu.cn.
authors.forename: Weimin
authors.initials: W
authors.lastname: Mo
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310032, P. R. China. liqunjin@zjut.edu.cn xinquan@zjut.edu.cn and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, the Chinese Academy of Sciences, Lanzhou 730000, P. R. China.
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu