title: Noralashinol B, a norlignan with cytotoxicity from stem barks of Syringa pinnatifolia.
abstract: One new norlignan, noralashinol B (1), and one new natural product, proposed noralashinol C (2), were isolated in a continuous phytochemical investigation on the stem barks of Syringa pinnatifolia. Their structures were elucidated based on the analysis of spectroscopic data, including mass spectrometry and 1D and 2D NMR spectroscopies, and the absolute configuration was determined by experimental and calculated electronic circular dichroism. Compound 1 showed a weak cytotoxicity against HepG2 hepatic cancer cells with its IC50value of 31.7 μM. Furthermore, 1 induced apoptosis of HepG2 cells in a dose-dependent manner at concentrations of 0-80.0 μM.
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100102 , China.
authors.forename: Rui-Fei
authors.initials: RF
authors.lastname: Zhang
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100102 , China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Feng
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100102 , China.
authors.forename: Guo-Zhu
authors.initials: GZ
authors.lastname: Su
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100102 , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yin
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.|b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100102 , China.
authors.forename: Xin-Yao
authors.initials: XY
authors.lastname: Yang
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.
authors.forename: Yun-Fang
authors.initials: YF
authors.lastname: Zhao
authors.affiliation: b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100102 , China.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Li
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Tu
authors.affiliation: a Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China.
authors.forename: Xing-Yun
authors.initials: XY
authors.lastname: Chai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D031662:Syringa / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; C000616942:noralashinol B
keywords: Syringa pinnatifolia; calculated ECD; cytotoxicity; noralashinol B; noralashinol C; norlignan