title: Parietal lobe critically supports successful paired immediate and single-item delayed memory for targets.
abstract: The parietal lobe is important for successful recognition memory, but its role is not yet fully understood. We investigated the parietal lobes' contribution to immediate paired-associate memory and delayed item-recognition memory separately for hits (targets) and correct rejections (distractors). We compared the behavioral performance of 56 patients with known parietal and medial temporal lobe dysfunction (i.e. early Alzheimer's Disease) to 56 healthy control participants in an immediate paired and delayed single item object memory task. Additionally, we performed voxel-based morphometry analyses to investigate the functional-neuroanatomic relationships between performance and voxel-based estimates of atrophy in whole-brain analyses. Behaviorally, all participants performed better identifying targets than rejecting distractors. The voxel-based morphometry analyses associated atrophy in the right ventral parietal cortex with fewer correct responses to familiar items (i.e. hits) in the immediate and delayed conditions. Additionally, medial temporal lobe integrity correlated with better performance in rejecting distractors, but not in identifying targets, in the immediate paired-associate task. Our findings suggest that the parietal lobe critically supports successful immediate and delayed target recognition memory, and that the ventral aspect of the parietal cortex and the medial temporal lobe may have complementary preferences for identifying targets and rejecting distractors, respectively, during recognition memory.
authors.affiliation: Memory Clinic, University Center for Medicine of Aging Basel, Felix Platter Hospital, Burgfelderstrasse 101, Postfach, CH-4002 Basel, Switzerland. Electronic address: sabine.krumm@fps-basel.ch.
authors.forename: Sabine
authors.initials: S
authors.lastname: Krumm
authors.affiliation: Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, PO Box 1510, FI-00076 Aalto, Finland. Electronic address: sasa.kivisaari@aalto.fi.
authors.forename: Sasa L
authors.initials: SL
authors.lastname: Kivisaari
authors.affiliation: Memory Clinic, University Center for Medicine of Aging Basel, Felix Platter Hospital, Burgfelderstrasse 101, Postfach, CH-4002 Basel, Switzerland; Faculty of Psychology, University of Basel, Missionsstrasse 60/62, CH-4055 Basel, Switzerland. Electronic address: andreas.monsch@unibas.ch.
authors.forename: Andreas U
authors.initials: AU
authors.lastname: Monsch
authors.affiliation: Department of Radiology, Division of Diagnostic and Interventional Neuroradiology University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland. Electronic address: julia.reinhardt@usb.ch.
authors.forename: Julia
authors.initials: J
authors.lastname: Reinhardt
authors.affiliation: Department of Radiology and of Neuroradiology, University Hospital Schleswig-Holstein, Arnold-Heller-Strasse 3, Haus 41, D-24105 Kiel, Germany; Medical Radiological Institute (MRI), Bahnhofplatz 3, CH-8001 Zurich, Switzerland. Electronic address: sulmer@mri-roentgen.ch.
authors.forename: Stephan
authors.initials: S
authors.lastname: Ulmer
authors.affiliation: Faculty of Psychology, University of Basel, Missionsstrasse 60/62, CH-4055 Basel, Switzerland; Department of Radiology, Division of Diagnostic and Interventional Neuroradiology University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland. Electronic address: christoph.stippich@usb.ch.
authors.forename: Christoph
authors.initials: C
authors.lastname: Stippich
authors.affiliation: Memory Clinic, University Center for Medicine of Aging Basel, Felix Platter Hospital, Burgfelderstrasse 101, Postfach, CH-4002 Basel, Switzerland; Faculty of Medicine, University of Basel, Klingelbergstr. 61, CH-4056 Basel, Switzerland. Electronic address: reto.kressig@fps-basel.ch.
authors.forename: Reto W
authors.initials: RW
authors.lastname: Kressig
authors.affiliation: Memory Clinic, University Center for Medicine of Aging Basel, Felix Platter Hospital, Burgfelderstrasse 101, Postfach, CH-4002 Basel, Switzerland; Faculty of Psychology, University of Basel, Missionsstrasse 60/62, CH-4055 Basel, Switzerland; Centre for Speech, Language and the Brain, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom. Electronic address: kirsten.taylor@roche.com.
authors.forename: Kirsten I
authors.initials: KI
authors.lastname: Taylor
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology*
keywords: Alzheimers’ dementia; Atrophy; Parietal lobe; Recognition memory; Voxel-based morphometry