title: Panel 8: Report on Recent Advances in Molecular and Cellular Biochemistry.
abstract: Objectives To update the medical literature on recent cellular and molecular advances in otitis media disease models with a principal focus on developments in the past 5 years. We also aim to explain recent translational advances in cellular and molecular biology that have influenced our understanding and management of otitis media. Data Sources PubMed-indexed peer-reviewed articles. Review Methods A comprehensive review of the literature was conducted with the term otitis media and the following search terms: molecular biology, cell biology, innate immunity, oxidative stress, mucins, molecular diagnostics. Included articles were published in the English language from January 1, 2010, to July 31, 2015. Implications for Practice The molecular understanding of otitis media disease progression has rapidly advanced over the last 5 years. The roles of inflammation, mucins, and cell signaling mechanisms have been elucidated and defined. Advances in the field provide a plethora of opportunities for innovative molecular targeting in the development of novel therapeutic strategies for otitis media.
authors.affiliation: 1 Shiekh Zayed Institute for Pediatric Surgical Innovation, Pediatric Otolaryngology, Children's National Health System, Washington, DC, USA.
authors.forename: Diego
authors.initials: D
authors.lastname: Preciado
authors.affiliation: 2 Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Granath
authors.affiliation: 3 Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Jizhen
authors.initials: J
authors.lastname: Lin
authors.affiliation: 1 Shiekh Zayed Institute for Pediatric Surgical Innovation, Pediatric Otolaryngology, Children's National Health System, Washington, DC, USA.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Val
authors.affiliation: 4 Division of Otolaryngology, Department of Surgery, University of California, San Diego, California, USA.
authors.forename: Arwa
authors.initials: A
authors.lastname: Kurabi
authors.affiliation: 5 Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: Nikki
authors.initials: N
authors.lastname: Johnston
authors.affiliation: 6 Department of Surgery, Paediatrics and Child Health, University of Western Australia, Perth, Australia.
authors.forename: Shyan
authors.initials: S
authors.lastname: Vijayasekaran
authors.affiliation: 7 Division of Pediatric Otolaryngology, Connecticut Children's Hospital, Hartford, Connecticut, USA.
authors.forename: Tulio
authors.initials: T
authors.lastname: Valdez
authors.affiliation: 8 Institute for Systems Research, University of Maryland, College Park, Maryland, USA.
authors.forename: Didier
authors.initials: D
authors.lastname: Depireux
authors.affiliation: 9 Departments of Otolaryngology, Oral and Maxillofacial Surgery, and Pediatrics, Lund University, Lund, Sweden.
authors.forename: Ann
authors.initials: A
authors.lastname: Hermansson
mesh_terms: D000818:Animals; D003226:Congresses as Topic; D018450:Disease Progression; D016503:Drug Delivery Systems; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate; D010033:Otitis Media / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D015398:Signal Transduction; D041623:Tomography, Optical Coherence
keywords: NETs; Toll-like receptors; biofilms; cell biology; innate immunity; molecular biology; molecular diagnostics; mucins; optical coherence tomography; otitis media; oxidative stress