title: Single nucleotide polymorphisms of the haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination.
abstract: The present study analyzed polymorphisms of the 5' flanking region (from nt -840 to +151) of the haptoglobin gene in 120 patients with advanced non-small cell lung cancer (NSCLC) receiving personalized peptide vaccinations. In the region, six single nucleotide polymorphisms (SNPs) were confirmed, of which two, rs5472 and rs9927981, were completely linked to each other. The minor allele frequencies of rs5472/rs9927981 and rs4788458 were higher than those of the other three SNPs. The genotype frequencies of rs5472 or rs9927981 were A/A or C/C (42.5%, n=51), A/G or C/T (40.8%, n=49), and G/G or T/T (16.7%, n=20), respectively; and those of rs4788458 were T/T (34.2%, n=41), T/C (40.0%, n=48), and C/C (25.8%, n=31). The association between polymorphism rs5472/rs9927981 and prognosis, or between rs4788458 and prognosis, was analyzed further. However, no correlation was found between these SNPs and overall survival, regardless of subgroup analysis of gender, histology or concurrent therapy. These results suggest that the polymorphisms rs5472/rs9927981 and rs4788458 are not useful prognostic tools for patients with NSCLC treated with personalized peptide vaccination.
authors.affiliation: Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Waki
authors.affiliation: Kurume University Cancer Vaccine Center, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Yamada
authors.affiliation: Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Yoshiyama
authors.affiliation: Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Terazaki
authors.affiliation: Kurume University Cancer Vaccine Center, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Sakamoto
authors.affiliation: Department of Pulmonary Medicine, Sendai Kousei Hospital, Sendai, Miyagi 980-0873, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Sugawara
authors.affiliation: Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Shinzo
authors.initials: S
authors.lastname: Takamori
authors.affiliation: Kurume University Cancer Vaccine Center, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Kyogo
authors.initials: K
authors.lastname: Itoh
authors.affiliation: Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yamada
keywords: SNPs; haptoglobin; lung cancer; peptide vaccine; prognosis