title: Accuracy of using serum D-dimer for diagnosis of acute intestinal ischemia: A meta-analysis.
abstract: OBJECTIVE
  The purpose of this meta-analysis is to comprehensively assess the accuracy of serum D-dimer for the diagnosis of acute intestinal ischemia.
  
  
  METHODS
  Diagnostic studies of D-dimer for accurate diagnosis of acute intestinal ischemia were extracted from 6 databases, and prospective and retrospective studies that provided adequate data on sensitivity and specificity were included here. Sensitivity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated. The overall diagnostic performance of D-dimer was assessed by plotting a summary receiver operating characteristic curve (SROC) and calculating the area under the curve (AUC).
  
  
  RESULTS
  A total of 1300 patients with suspected acute intestinal ischemia from 12 studies met the inclusion criteria. The combined sensitivity, specificity, PLR, NLR, and DOR were 0.94 (95% CI: 0.87-0.97), 0.50 (95% CI: 0.40-0.61), 1.9 (95% CI: 1.5-2.3), 0.12 (95% CI: 0.05-0.26), and 16 (95% CI: 7-39), respectively. The AUC was 0.81 (95% CI: 0.78-0.84).
  
  
  CONCLUSIONS
  The results of this meta-analysis suggested that plasma D-dimer detection might be a useful means of identifying patients with acute intestinal ischemia of the abdomen.
authors.affiliation: Department of Gastrointestinal Surgery, Second Affiliated Hospital of Kunming Medical University Research Center for Surgical Clinical Nutrition, Kunming Professor Yang Hua Research Station, Yunnan Province, China.
authors.forename: Da-Li
authors.initials: DL
authors.lastname: Sun
authors.forename: Shu-Min
authors.initials: SM
authors.lastname: Li
authors.forename: Yun-Yun
authors.initials: YY
authors.lastname: Cen
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Xu
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Li
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Sun
authors.forename: Yu-Xing
authors.initials: YX
authors.lastname: Qi
authors.forename: Yue-Ying
authors.initials: YY
authors.lastname: Lin
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: An
authors.forename: Kun
authors.initials: K
authors.lastname: Su
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Li
authors.forename: Peng-Yuan
authors.initials: PY
authors.lastname: Xu
mesh_terms: D015415:Biomarkers / Q000097:blood; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D007410:Intestinal Diseases / Q000097:blood / Q000175:diagnosis*; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000097:blood / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D