title: Nanocellulose crystals derivative-silica hybrid sol open tubular capillary column for enantioseparation.
abstract: Broad spectrum separation of chiral compounds is a challenge task for analysts. It is significant for preparation of chiral stationary phase and selection of separation technology in the field. Here, we present a novel nanocellulose crystals (NCCs) which were derivation with 3,5-dimethylphenyl isocynate (DMPC) and silane with 3-triethoxysilylpropylisocyanate form sol in tetraethylorthosilicate (TEOS) and layer-by-layer self-assembly in the inner of capillary to fabricate the organic-inorganic hybrid open tubular capillary column (DMPC/NCCs-OTC) for enantiomers separation by capillary electrochromatography technology (CEC). The experimental results verified that this coating column has the broad spectrum separation ability and high resolution efficiency for thirteen different enantiomers at the optimal CEC conditions. The mechanizations of DMPC/NCCs-OTC modified layer numbers and structure effect on chiral separation performance have been investigated and compared. Although the limitation and difficulty in fabrication of open tubular coating column, this work provided the preparation method of stability, controlled, long column life, adequate repeatability and satisfied enantioseparation performance.
authors.affiliation: Key laboratory of Chemistry of Northwestern Plant Resources and Key laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors.forename: Shuqing
authors.initials: S
authors.lastname: Dong
authors.affiliation: Key laboratory of Chemistry of Northwestern Plant Resources and Key laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Yaming
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Key laboratory of Chemistry of Northwestern Plant Resources and Key laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key laboratory of Chemistry of Northwestern Plant Resources and Key laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Key laboratory of Chemistry of Northwestern Plant Resources and Key laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors.forename: Guoying
authors.initials: G
authors.lastname: Luo
authors.affiliation: Key laboratory of Chemistry of Northwestern Plant Resources and Key laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, PR China. Electronic address: Zhaol@licp.cas.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
keywords: Enantioseparation; Layer-by-layer self-assembly; Nanocellulose crystals derivative; Open tubular capillary column; Organic-inorganic hybrid