title: BMP-2-induced bone formation and neural inflammation.
abstract: Bone morphogenetic protein-2 (BMP-2), a potent osteoinductive cytokine from the transforming growth factor beta (TGF-β) family, is currently the most commonly used protein-based bone graft substitute. Although clinical use of BMP-2 has significantly increased in recent years, its prominence has also highlighted various adverse events, including induction of inflammation. This review will elucidate the relationship between BMP-2 and inflammation, with an emphasis on peripheral nerve inflammation and its sequelae. As well, we review the potential additive roles of nerve released factors with BMP2 in the context of bone formation.
authors.affiliation: Department of Pathology, Johns Hopkins University, 21205, United States.
authors.forename: Vi
authors.initials: V
authors.lastname: Nguyen
authors.affiliation: Department of Pathology, Johns Hopkins University, 21205, United States.
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Meyers
authors.affiliation: Department of Pathology, Johns Hopkins University, 21205, United States.
authors.forename: Noah
authors.initials: N
authors.lastname: Yan
authors.affiliation: Department of Surgery, University of Michigan, 48109, United States.
authors.forename: Shailesh
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: Department of Surgery, University of Michigan, 48109, United States.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Levi
authors.affiliation: Department of Pathology, Johns Hopkins University, 21205, United States.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: James
keywords: Bone morphogenetic protein; Inflammation; Neural inflammation; Neuritis; Osteogenesis; Skeletal engineering