title: Sleep Disorder as a Triggering Factor for Relapse in Multiple Sclerosis.
abstract: To determine the effect of sleep disturbances on predisposing multiple sclerosis (MS) patients for acute relapse.
  
  
  
  This case-control study was conducted on 80 MS patients including 40 patients in the remission phase and 40 in the relapse phase. Patients were asked to fill in the Pittsburgh Sleep Quality Index to determine their sleep quality during the previous month. Individuals with scores of 5 or less were considered having normal sleep quality.
  
  
  
  Mean ± SD ages were 32.5 ± 7.7 and 30.2 ± 7.2 years among patients with and without acute relapses, respectively (p > 0.05). The mean disease duration and disease severity (according to Expanded Disability Status Scale [EDSS]) were comparable across the groups (p > 0.05). Among those with and without acute exacerbations, 87.5 and 50% had poor sleep quality, respectively (p = 0.0001), with OR of 1.75 (95% CI 1.25-2.43). The age, gender, EDSS, and disease duration did not associate with sleep quality in either groups (p > 0.05).
  
  
  
  This study showed that sleep disturbance might be a trigger for an acute MS exacerbation. Increasing the awareness of specialists and routine screening of sleep disorders in MS patients are warranted, as treatment of these disorders might decrease the likelihood of acute relapses.
authors.affiliation: MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sahraian
authors.forename: Saeed
authors.initials: S
authors.lastname: Rezaali
authors.forename: Melina
authors.initials: M
authors.lastname: Hosseiny
authors.forename: Rozita
authors.initials: R
authors.lastname: Doosti
authors.forename: Ali
authors.initials: A
authors.lastname: Tajik
authors.forename: Abdorreza
authors.initials: A
authors.lastname: Naser Moghadasi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D012008:Recurrence; D012893:Sleep Wake Disorders / Q000150:complications*
keywords: Multiple sclerosis; Pittsburgh Sleep Quality Index; Relapse; Sleep disorder