title: Tumefactive Fibroinflammatory Lesion: A Diagnostic Dilemma.
abstract: Tumefactive fibroinflammatory lesions (TFLs) are rare idiopathic benign fibrosclerosing lesions that clinically simulate a malignancy. TFLs are seen more frequently in males between 10 and 74 years of age. The usual site of involvement is the head and neck region, but rarely the extremities may be involved. Coexisting fibrosclerotic processes have been reported including retroperitoneal fibrosis, sclerosing cholangitis, sclerosing mediastinal fibrosis, and orbital pseudotumors. The etiology of this poorly understood entity remains unknown. Possible suggestions include exaggerated responses or autoimmune reactions to any chronic infection. The clinical and radiological appearance of TFLs is that of malignancy, but histopathology reveals them to be a benign process broadly classified under non-neoplastic, fibroinflammatory proliferations. The treatment strategies for these lesions are not well defined and variable and include steroids, surgery, and radiotherapy either alone or in combination. TFLs, albeit not fatal, have a high recurrence rate; patients should, therefore, be kept on long-term follow-up. We describe a young female patient presenting with a rapidly developing cheek swelling, which was diagnosed histopathologically as a TFLs.
authors.affiliation: Department of Pathology, Pt BDS PGIMS, University of Health Sciences, Rohtak, India.
authors.forename: Promil
authors.initials: P
authors.lastname: Jain
authors.affiliation: Department of Pathology, Pt BDS PGIMS, University of Health Sciences, Rohtak, India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Sen
authors.affiliation: Department of Pathology, Pt BDS PGIMS, University of Health Sciences, Rohtak, India.
authors.forename: Nisha
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Pathology, Pt BDS PGIMS, University of Health Sciences, Rohtak, India.
authors.forename: Shilpi
authors.initials: S
authors.lastname: Bhargava
authors.affiliation: Department of Oral Pathology, PGIDS, University of Health Sciences, Rohtak, India.
authors.forename: Virender
authors.initials: V
authors.lastname: Singh
keywords: Neoplasms; Sinus; Tumefactive fibroinflammatory lesion