title: Do intraoperative pyloric interventions predict the need for postoperative endoscopic interventions after minimally invasive esophagectomy?
abstract: Intraoperative pyloric procedures are often performed during esophagectomies to reduce the rates of gastric conduit dysfunction. They include pyloroplasty (PP), pyloromyotomy (PM), and pylorus botulinum toxin type-A injections (BI). Despite these procedures, patients frequently warrant further endoscopic interventions. The aim of this study is to compare intraoperative pyloric procedures and the rates of postoperative endoscopic interventions following minimally invasive esophagectomy (MIE). We identified patients who underwent MIE for esophageal carcinoma and grouped them as 'None' (no intervention), 'PP', 'PM', or 'BI' based on intraoperative pyloric procedure type. The rates of endoscopic interventions for the first six postoperative months were compared. To adjust for variability due to MIE type, the rates of >1 interventions were compared using a zero-inflated Poisson regression analysis. Significance was established at P < 0.05. There were 146 patients who underwent an MIE for esophageal cancer from 2008 to 2015; 77.4% were three-hole MIE, and 22.6% were Ivor- Lewis MIE. BI was most frequent in Ivor-Lewis patients (63.5%), while PP was most frequent (46.9%) in three-hole patients. Postoperative endoscopic interventions occurred in 38 patients (26.0%). The BI group had the highest percentage of patients requiring a postoperative intervention (n = 13, 31.7%). After adjusting for higher rates of interventions in three-hole MIE patients, the BI and None groups had the lowest rates of >1 postoperative interventions. Our data did not show superiority of any pyloric intervention in preventing endoscopic interventions. The patients who received BI to the pylorus demonstrated a trend toward a greater likelihood of having a postoperative intervention. However when adjusted for type of MIE, the BI and None groups had lower rates of subsequent multiple interventions. Further research is needed to determine if the choice of intraoperative pyloric procedure type significantly affects quality of life, morbidity, and overall prognosis in these patients.
authors.affiliation: Department of Surgery.
authors.forename: D N
authors.initials: DN
authors.lastname: Giugliano
authors.affiliation: Department of Surgery.
authors.forename: A C
authors.initials: AC
authors.lastname: Berger
authors.affiliation: Department of Surgery.
authors.forename: H
authors.initials: H
authors.lastname: Meidl
authors.affiliation: Department of Surgery.
authors.forename: M J
authors.initials: MJ
authors.lastname: Pucci
authors.affiliation: Department of Surgery.
authors.forename: E L
authors.initials: EL
authors.lastname: Rosato
authors.affiliation: Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: S W
authors.initials: SW
authors.lastname: Keith
authors.affiliation: Department of Surgery.
authors.forename: N R
authors.initials: NR
authors.lastname: Evans
authors.affiliation: Department of Surgery.
authors.forename: F
authors.initials: F
authors.lastname: Palazzo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D016629:Esophagectomy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D007430:Intraoperative Care / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D011184:Postoperative Period; D011708:Pylorus / Q000601:surgery*; D012044:Regression Analysis; D012189:Retrospective Studies; D013272:Stomach Diseases / Q000209:etiology / Q000517:prevention & control / Q000601:surgery; D016896:Treatment Outcome
keywords: endoscopic dilatation; endoscopy; esophageal cancer; esophagectomy; pylorus