title: The impact of locoregional treatment on survival of patients with primary metastatic breast cancer.
abstract: The aim of the study was to investigate the impact of primary tumor locoregional treatment (surgery or/and radiotherapy) on overall survival in patients with primary metastatic breast cancer (PMBC).
  
  
  METHODS
  This retrospective study included 295 wo-men aged from 23 to 76 years with PMBC. Among the 295 patients, the effect of locoregional treatment of primary tumor on survival outcomes was evaluated in 177 women with distant metastases at diagnosis of breast cancer. 35 patient received breast surgery (group 1), 95 patients with PMBC - radiotherapy (group 2) and 47 patients - combination of breast surgery and radiation (group 3). The remaining 118 patients didn't receive surgery or/and radiotherapy (group 4). All patients received systemic cytotoxic chemotherapy.
  
  
  RESULTS
  The groups of patients with PMBC did not differ significantly by age, menstrual function, ER status, Her2 receptor status, site of metastasis and number of metastatic lesions. 2- and 5-year overall survival in patients of group 1 was 54 and 32%, group 2 - 47 and 8%, group 3 - 73 and 18%, whereas in patients from group 4 - 26 and 9%, respectively. The median survival of patients who underwent surgery was 36 months, patients with PMBC who received radiotherapy - 24 months, patients who obtained combination of breast surgery and radiation - 30 months vs 18 months in patients who did not undergo primary tumor locoregional treatment.
  
  
  CONCLUSIONS
  The results of this study showed a favourable effect of locoregional treatment in patients with PMBC.
authors.affiliation: Department of Oncology, O.O. Bogomolets National Medical University, Kyiv 03115, Ukraine.
authors.forename: R
authors.initials: R
authors.lastname: Liubota
authors.affiliation: Department of Oncology, O.O. Bogomolets National Medical University, Kyiv 03115, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Cheshuk
authors.affiliation: Department of Oncology, O.O. Bogomolets National Medical University, Kyiv 03115, Ukraine.
authors.forename: R
authors.initials: R
authors.lastname: Vereshchako
authors.affiliation: Department of Oncology, O.O. Bogomolets National Medical University, Kyiv 03115, Ukraine.
authors.forename: O
authors.initials: O
authors.lastname: Zotov
authors.affiliation: Department of Oncology, O.O. Bogomolets National Medical University, Kyiv 03115, Ukraine.
authors.forename: V
authors.initials: V
authors.lastname: Zaichuk
authors.affiliation: Municipal City Clinical Oncological Centre, Kyiv 03115, Ukraine.
authors.forename: N
authors.initials: N
authors.lastname: Anikusko
authors.affiliation: Municipal City Clinical Oncological Centre, Kyiv 03115, Ukraine.
authors.forename: I
authors.initials: I
authors.lastname: Liubota
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods* / Q000706:statistics & numerical data; D012189:Retrospective Studies; D055815:Young Adult