title: Clinical Inquiry: Do ACE inhibitors or ARBs help prevent kidney disease in patients with diabetes and normal BP?
abstract: Yes for angiotensin-converting enzyme (ACE) inhibitors, no for angiotensin receptor blockers (ARBs). A 2011 meta-analysis of 5 RCTs (total 2975 patients) that compared ACE inhibitor therapy with placebo in diabetic patients without hypertension and albuminuria found that ACE inhibitors reduced the risk of new-onset microalbuminuria or macroalbuminuria by 18% (relative risk [RR]=0.82; 95% confidence interval [CI], 0.73-0.92).
authors.affiliation: UPMC St. Margaret, Pittsburgh, PA, USA.
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Trietley
authors.affiliation: UPMC St. Margaret, Pittsburgh, PA, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Wilson
authors.affiliation: UPMC St. Margaret, Pittsburgh, PA, USA.
authors.forename: Parul
authors.initials: P
authors.lastname: Chaudhri
authors.affiliation: UPMC St. Margaret, Pittsburgh, PA, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Payette
authors.affiliation: Texas Tech University Health Science Center, Dallas, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Higbea
authors.affiliation: Family Physician Inquiries Network, Iowa City, IA, USA.
authors.forename: Joan
authors.initials: J
authors.lastname: Nashelsky
mesh_terms: D000419:Albuminuria / Q000188:drug therapy / Q000209:etiology*; D057911:Angiotensin Receptor Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D048909:Diabetes Complications / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology*; D018570:Risk Assessment
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents