title: Therapeutic approaches for the delivery of TNF-α siRNA.
abstract: Immune-mediated diseases are emerging as a major healthcare concern in the present era. TNF-α, a proinflammatory cytokine, plays a major role in the manifestation of these diseases by mediating different pathways and inducing the expression of other cytokines. In last decades, monoclonal antibodies and extracellular portion of human TNF-α receptors are explored in this area; however, the risk of immunological response and undesired effects urge a need to develop more effective therapies to control TNF-α levels. siRNA therapeutic strategies are emerging for the treatment of myriad of diseases, but the delivery challenges associated with siRNA require the development of suitable delivery vectors. For delivery of TNF-α siRNA, both viral and nonviral vectors are explored. This review attempts to describe different delivery approaches for TNF-α siRNA with special focus on nonviral delivery vectors.
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad 500037, India.
authors.forename: Palpandi
authors.initials: P
authors.lastname: Pandi
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad 500037, India.
authors.forename: Anjali
authors.initials: A
authors.lastname: Jain
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad 500037, India.
authors.forename: Saka
authors.initials: S
authors.lastname: Raju
authors.affiliation: Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad 500037, India.
authors.forename: Wahid
authors.initials: W
authors.lastname: Khan
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D034741:RNA, Small Interfering / Q000008:administration & dosage*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage* / Q000235:genetics
chemical_list: D034741:RNA, Small Interfering; D014409:Tumor Necrosis Factor-alpha
keywords: RNAi; TNF-α siRNA; nonviral delivery vectors