title: Attenuation of Resting but Not Load-Mediated Protein Synthesis in Prostate Cancer Patients on Androgen Deprivation.
abstract: BACKGROUND
  Androgen deprivation therapy (ADT) is a common prostate cancer (PCa) treatment but results in muscular atrophy. Periodic increases in muscle protein synthesis (MPS) that occur after resistance exercise or protein intake may ameliorate this muscle loss, but the impact of these anabolic stimuli during ADT is unclear.
  
  
  OBJECTIVE
  To determine the acute MPS response to whey protein supplementation with and without resistance exercise during ADT.
  
  
  METHODS
  Acute response in PCa patients vs age-matched controls (CON).
  
  
  METHODS
  Academic laboratory setting.
  
  
  METHODS
  PCa patients on ADT (N = 8) and CON (N = 10).
  
  
  METHODS
  A standardized diet was consumed for 2 days prior to performing unilateral knee extension resistance exercise followed by ingestion of 40 g of whey protein.
  
  
  METHODS
  Bilateral biopsies and stable isotope infusions were used to determine MPS rates at rest after protein ingestion with and without resistance exercise.
  
  
  RESULTS
  Baseline MPS during ADT was suppressed relative to CON (P = 0.01). Protein consumption stimulated MPS in both groups (approximate twofold increase, both P < 0.001), but to a greater extent in CON (P = 0.003). Protein plus resistance exercise increased MPS (∼3.4-fold increase, both P < 0.001) to a greater extent than did protein alone (P < 0.001), but with no difference between groups (P = 0.380).
  
  
  CONCLUSIONS
  ADT reduces basal and protein feeding-induced rises in MPS; however, combined protein ingestion with resistance exercise stimulated MPS to a similar degree as CON. Testosterone appears to play a role in maintaining muscle mass but is not necessary to initiate a robust response in MPS following resistance exercise when combined with protein ingestion.
authors.affiliation: Institute of Sport, Exercise, and Active Living and.|Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Victoria 3021, Australia.|Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, North Carolina 27599.
authors.forename: Erik D
authors.initials: ED
authors.lastname: Hanson
authors.affiliation: Institute of Sport, Exercise, and Active Living and.
authors.forename: André R
authors.initials: AR
authors.lastname: Nelson
authors.affiliation: Department of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
authors.forename: Daniel W D
authors.initials: DW
authors.lastname: West
authors.affiliation: Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3000, Australia; and.
authors.forename: John A
authors.initials: JA
authors.lastname: Violet
authors.affiliation: Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Victoria 3021, Australia.
authors.forename: Lannie
authors.initials: L
authors.lastname: O'Keefe
authors.affiliation: Department of Kinesiology, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Phillips
authors.affiliation: Institute of Sport, Exercise, and Active Living and.|Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Victoria 3021, Australia.|Australian Institute for Musculoskeletal Science, Melbourne, Victoria 3021, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Hayes
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects*; D016022:Case-Control Studies; D004044:Dietary Proteins / Q000494:pharmacology*; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000096:biosynthesis / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009133:Muscular Atrophy / Q000139:chemically induced* / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D014176:Protein Biosynthesis / Q000187:drug effects; D055070:Resistance Training; D000067816:Whey Proteins / Q000494:pharmacology*
chemical_list: D000726:Androgen Antagonists; D004044:Dietary Proteins; D009124:Muscle Proteins; D000067816:Whey Proteins