title: The value of Nigella sativa in the treatment of experimentally induced rhinosinusitis.
abstract: The aim of this study was to investigate the effect of Nigella sativa and cephalexin in the therapy of experimental bacterial rhinosinusitis. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits were divided into five groups; control (n = 6), N. sativa 50 mg/ kg/d (n = 6), N. sativa 100 mg/kg/d (n = 6), N. sativa 200 mg/kg/d (n = 6), and cephalexin 20 mg/kg/d (n = 6) groups. N. sativa was given orally for 7 days. The same volume of normal saline (0.9% NaCl) was given as a vehicle to the control group for the same period. After treatment period, sinus mucosa samples were evaluated using stereological and histopathological methods. Half of the maxillary sinus mucosa samples were frozen at -800C for further analysis of NO levels. Pathology revealed a severe acute inflammatory process in rabbits treated with saline. Only mild inflammation was determined in cephalexin group, N. sativa 100 mg/kg/d and N. sativa 200 mg/kg/d groups. The level of NO increased in the saline group was significantly reduced in all treatment groups. N. sativa may prevent histopathological changes of rhinosinusitis via decreased NO levels in a dose dependent manner and can be used in the treatment of rhinosinusitis diseases.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Yoruk
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Tatar
authors.affiliation: Department of Histology and Embryology, School of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: O N
authors.initials: ON
authors.lastname: Keles
authors.affiliation: Department of Chemistry, Faculty of Science and Art, Kilis 7 Aralık University, Kilis, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Cakir
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D031881:Nigella sativa; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011817:Rabbits; D012220:Rhinitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy*
chemical_list: D010936:Plant Extracts
keywords: Neutrophil; Nigella sativa; Nitric Oxide; Rabbit; Rhinosinusitis