title: Expression of Adiponectin Receptor-1 and Prognosis of Epithelial Ovarian Cancer Patients.
abstract: BACKGROUND Adiponectin receptor-1 (AdipoR1) has been reported to be associated with the risk of obesity-associated malignancies, including epithelial ovarian cancer (EOC). The aim of this study was to determine if AdipoR1 could serve as a prognosis indicator for patients with EOC. MATERIAL AND METHODS In this study, expression of AdipoR1 in 73 EOC patients consecutively admitted to our hospital was detected by immunohistochemical staining. Univariate and multivariate analyses were performed to assess the relationship between AdipoR1 expression level and progression-free survival (PFS) and overall survival (OS) rates in patients. RESULTS A relatively lower expression of AdipoR1 in the cancerous tissues was detected compared to normal ovarian tissues, but the difference was not significant (p>0.05). AdipoR1 expression level in EOC patients was negatively correlated with advanced FIGO stages in patients and tumor differentiation, but had no correlation with pathological types, presenting of ascites, shorter platinum-free interval (PFI), diabetes, preoperative and postoperative body mass index (BMI), or platelet counts (p>0.05). Moreover, patients with AdipoR1 expression had a significantly longer PFS and OS compared to the negative expression group (p<0.001). CONCLUSIONS Our findings suggest that AdipoR1 expression level in cancerous tissues might serve as an independent prognostic indicator in EOC patients and is associated with longer PFS and OS.
authors.affiliation: Department of Oncology, The 2nd Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (mainland).
authors.forename: Xiahui
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Oncology, The 2nd Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (mainland).
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Oncology, The 2nd Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (mainland).
authors.forename: Liping
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of Oncology , The 2nd Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (mainland).
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Oncology, The 2nd Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (mainland).
authors.forename: Kui
authors.initials: K
authors.lastname: Jiang
mesh_terms: D052242:Adiponectin / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D000077216:Carcinoma, Ovarian Epithelial; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D054419:Receptors, Adiponectin / Q000096:biosynthesis* / Q000235:genetics; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: C475418:ADIPOR1 protein, human; D052242:Adiponectin; D014408:Biomarkers, Tumor; D054419:Receptors, Adiponectin