title: Screening for Celiac Disease: US Preventive Services Task Force Recommendation Statement.
abstract: Celiac disease is caused by an immune response in persons who are genetically susceptible to dietary gluten, a protein complex found in wheat, rye, and barley. Ingestion of gluten by persons with celiac disease causes immune-mediated inflammatory damage to the small intestine.
  
  
  
  To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for celiac disease.
  
  
  
  The USPSTF reviewed the evidence on the accuracy of screening in asymptomatic adults, adolescents, and children; the potential benefits and harms of screening vs not screening and targeted vs universal screening; and the benefits and harms of treatment of screen-detected celiac disease. The USPSTF also reviewed contextual information on the prevalence of celiac disease among patients without obvious symptoms and the natural history of subclinical celiac disease.
  
  
  
  The USPSTF found inadequate evidence on the accuracy of screening for celiac disease, the potential benefits and harms of screening vs not screening or targeted vs universal screening, and the potential benefits and harms of treatment of screen-detected celiac disease.
  
  
  
  The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for celiac disease in asymptomatic persons. (I statement).
authors.affiliation: University of California, San Francisco.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Bibbins-Domingo
authors.affiliation: Group Health Research Institute, Seattle, Washington.
authors.forename: David C
authors.initials: DC
authors.lastname: Grossman
authors.affiliation: University of Iowa, Iowa City.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Curry
authors.affiliation: Harvard Medical School, Boston, Massachusetts.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Barry
authors.affiliation: Columbia University, New York, New York.
authors.forename: Karina W
authors.initials: KW
authors.lastname: Davidson
authors.affiliation: University of Pennsylvania, Philadelphia.
authors.forename: Chyke A
authors.initials: CA
authors.lastname: Doubeni
authors.affiliation: University of Georgia, Athens.
authors.forename: Mark
authors.initials: M
authors.lastname: Ebell
authors.affiliation: Virginia Tech Carilion School of Medicine, Roanoke.
authors.forename: John W
authors.initials: JW
authors.lastname: Epling
authors.affiliation: Independent consultant, Washington, DC.
authors.forename: Jessica
authors.initials: J
authors.lastname: Herzstein
authors.affiliation: Duke University, Durham, North Carolina.
authors.forename: Alex R
authors.initials: AR
authors.lastname: Kemper
authors.affiliation: Fairfax Family Practice Residency, Fairfax, Virginia12Virginia Commonwealth University, Richmond.
authors.forename: Alex H
authors.initials: AH
authors.lastname: Krist
authors.affiliation: Yale University, New Haven, Connecticut.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Kurth
authors.affiliation: University of Alabama at Birmingham.
authors.forename: C Seth
authors.initials: CS
authors.lastname: Landefeld
authors.affiliation: University of California, Los Angeles.
authors.forename: Carol M
authors.initials: CM
authors.lastname: Mangione
authors.affiliation: Brown University, Providence, Rhode Island.
authors.forename: Maureen G
authors.initials: MG
authors.lastname: Phipps
authors.affiliation: Boston University, Boston, Massachusetts.
authors.forename: Michael
authors.initials: M
authors.lastname: Silverstein
authors.affiliation: Northwestern University, Evanston, Illinois.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Simon
authors.affiliation: University of Hawaii, Manoa.
authors.forename: Chien-Wen
authors.initials: CW
authors.lastname: Tseng
mesh_terms: D000293:Adolescent; D000328:Adult; D026683:Advisory Committees; D058070:Asymptomatic Diseases; D002446:Celiac Disease / Q000175:diagnosis* / Q000178:diet therapy / Q000453:epidemiology; D002648:Child; D055050:Diet, Gluten-Free; D042241:Early Diagnosis; D006801:Humans; D015995:Prevalence; D011314:Preventive Health Services; D014481:United States / Q000453:epidemiology