title: Promising therapeutic role of miR-27b in tumor.
abstract: MicroRNAs are small nonprotein-encoding RNAs ranging from 18 to 25 nucleotides in size and regulate multiple biological pathways via directly targeting a variety of associated genes in cancers. MicroRNA-27b is a highly conserved MicroRNA throughout vertebrates and there are two homologs (hsa-miR-27a and hsa-miR-27b) in humans. MicroRNA-27b is an intragenic microRNA located on chromosome 9q22.1 within the C9orf3 gene, clustering with miR-23b and miR-24-1 in human. As a frequently dysregulated microRNA in human cancers, microRNA-27b could function as a tumor suppressor or an oncogenic microRNA. More and more studies indicate that microRNA-27b is involved in affecting various biological processes, such as angiogenesis, proliferation, metastasis, and drug resistance, and thus may act as a promising therapeutic target in human cancers. In this review, we discuss the role of microRNA-27b in detail and offer novel insights into molecular targeting therapy for cancers.
authors.affiliation: 1 School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, P.R. China.|2 Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.affiliation: 2 Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, P.R. China.|3 The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ni
authors.affiliation: 2 Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: 2 Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, P.R. China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Huang
authors.affiliation: 4 The Graduate School, AnHui University of Traditional Chinese Medicine, Hefei, P.R. China.
authors.forename: Heng
authors.initials: H
authors.lastname: Deng
authors.affiliation: 2 Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: 1 School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, P.R. China.
authors.forename: Xuansheng
authors.initials: X
authors.lastname: Ding
authors.affiliation: 2 Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, P.R. China.|5 Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, P.R. China.
authors.forename: Jinhai
authors.initials: J
authors.lastname: Tang
mesh_terms: D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000473:pathology
chemical_list: C531388:MIRN27 microRNA, human; D035683:MicroRNAs
keywords: MicroRNA; biomarker; cancer; microRNA-27b; therapy