title: Comparison of Ramosetron with Palonosetron for Prevention of Postoperative Nausea and Vomiting in Patients Receiving Opioid-Based Intravenous Patient-Controlled Analgesia after Gynecological Laparoscopy.
abstract: We aimed to compare the effects of ramosetron and palonosetron in the prevention of postoperative nausea and vomiting (PONV) in patients that received opioid-based intravenous patient-controlled analgesia (IV-PCA) after gynecological laparoscopy. We reviewed the electronic medical records of 755 adults. Patients were classified into two groups, ramosetron (group R,n= 589) versus palonosetron (group P,n= 166). Based on their confounding factors, 152 subjects in each group were selected after the implementation of propensity score matching. The overall incidence of PONV at postoperative day (POD) 0 was lower in group R compared to group P (26.9% versus 36.8%;P= 0.043). The severity of nausea was lower in group R than in group P on postoperative day (POD) 0 (P= 0.012). Also, the complete responder proportion of patients was significantly higher in group R compared to that in group P on POD 0 (P= 0.043). In conclusion, ramosetron showed a greater efficacy in the prevention of postoperative nausea at POD 0 compared to palonosetron in patients after gynecological laparoscopy.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Inje University Seoul Paik Hospital, Seoul, Republic of Korea.
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Ahn
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Geun Joo
authors.identifier: 0000-0002-4653-4193
authors.initials: GJ
authors.lastname: Choi
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hyun
authors.identifier: 0000-0003-2844-5880
authors.initials: H
authors.lastname: Kang
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Chong Wha
authors.identifier: 0000-0001-9917-8738
authors.initials: CW
authors.lastname: Baek
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yong Hun
authors.initials: YH
authors.lastname: Jung
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Young Cheol
authors.initials: YC
authors.lastname: Woo
mesh_terms: D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled / Q000009:adverse effects; D000701:Analgesics, Opioid / Q000009:adverse effects; D001562:Benzimidazoles / Q000008:administration & dosage*; D057286:Electronic Health Records; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects; D006801:Humans; D007546:Isoquinolines / Q000008:administration & dosage*; D010535:Laparoscopy / Q000009:adverse effects; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy* / Q000503:physiopathology; D000077924:Palonosetron; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D011812:Quinuclidines / Q000008:administration & dosage*
chemical_list: D000701:Analgesics, Opioid; D001562:Benzimidazoles; D007546:Isoquinolines; D011812:Quinuclidines; D000077924:Palonosetron; C071315:ramosetron