title: Regulatory mechanisms, prophylaxis and treatment of vascular leakage following severe trauma and shock.
abstract: Vascular leakage, or increased vascular permeability, is a common but important pathological process for various critical diseases, including severe trauma, shock, sepsis, and multiple organ dysfunction syndrome (MODS), and has become one of the most important causes of death for intensive care units (ICU) patients. Currently, although there has been some progress in knowledge of the pathogenesis of these vascular disorders, the detailed mechanisms remain unclear, and effective prophylaxis and treatment are still lacking. In this study, we aimed to provide a review of the literature regarding the regulatory mechanisms and prophylaxis as well as the treatment of vascular leakage in critical diseases such as severe trauma and shock, which could be beneficial for the overall clinical treatment of vascular leakage disorders.
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042 China.
authors.forename: Chen-Yang
authors.initials: CY
authors.lastname: Duan
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042 China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042 China.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042 China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042 China.
authors.forename: Liang-Ming
authors.initials: LM
authors.lastname: Liu
mesh_terms: D020346:Aquaporins / Q000378:metabolism; D019559:Capillary Leak Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007362:Intensive Care Units / Q000458:organization & administration / Q000706:statistics & numerical data; D008565:Membrane Proteins / Q000378:metabolism; D009703:Nucleoside-Phosphate Kinase / Q000378:metabolism; D010539:Permeability; D018805:Sepsis / Q000209:etiology / Q000628:therapy; D012769:Shock / Q000150:complications / Q000628:therapy; D057900:Transcytosis / Q000502:physiology; D014947:Wounds and Injuries / Q000150:complications* / Q000628:therapy*; D062826:Zonula Occludens-1 Protein / Q000378:metabolism; D062827:Zonula Occludens-2 Protein / Q000378:metabolism
chemical_list: D020346:Aquaporins; D008565:Membrane Proteins; C569042:TJP1 protein, human; C569046:TJP2 protein, human; D062826:Zonula Occludens-1 Protein; D062827:Zonula Occludens-2 Protein; D009703:Nucleoside-Phosphate Kinase; C501307:MPP5 protein, human
keywords: Clinical critical diseases; Sepsis; Shock; Vascular leakage; Vascular permeability