title: Comparison of spatiotemporal prediction models of daily exposure of individuals to ambient nitrogen dioxide and ozone in Montreal, Canada.
abstract: In previous studies investigating the short-term health effects of ambient air pollution the exposure metric that is often used is the daily average across monitors, thus assuming that all individuals have the same daily exposure. Studies that incorporate space-time exposures of individuals are essential to further our understanding of the short-term health effects of ambient air pollution.
  
  
  
  As part of a longitudinal cohort study of the acute effects of air pollution that incorporated subject-specific information and medical histories of subjects throughout the follow-up, the purpose of this study was to develop and compare different prediction models using data from fixed-site monitors and other monitoring campaigns to estimate daily, spatially-resolved concentrations of ozone (O3) and nitrogen dioxide (NO2) of participants' residences in Montreal, 1991-2002.
  
  
  
  We used the following methods to predict spatially-resolved daily concentrations of O3and NO2for each geographic region in Montreal (defined by three-character postal code areas): (1) assigning concentrations from the nearest monitor; (2) spatial interpolation using inverse-distance weighting; (3) back-extrapolation from a land-use regression model from a dense monitoring survey, and; (4) a combination of a land-use and Bayesian maximum entropy model. We used a variety of indices of agreement to compare estimates of exposure assigned from the different methods, notably scatterplots of pairwise predictions, distribution of differences and computation of the absolute agreement intraclass correlation (ICC). For each pairwise prediction, we also produced maps of the ICCs by these regions indicating the spatial variability in the degree of agreement.
  
  
  
  We found some substantial differences in agreement across pairs of methods in daily mean predicted concentrations of O3and NO2. On a given day and postal code area the difference in the concentration assigned could be as high as 131ppb for O3and 108ppb for NO2. For both pollutants, better agreement was found between predictions from the nearest monitor and the inverse-distance weighting interpolation methods, with ICCs of 0.89 (95% confidence interval (CI): 0.89, 0.89) for O3and 0.81 (95%CI: 0.80, 0.81) for NO2, respectively. For this pair of methods the maximum difference on a given day and postal code area was 36ppb for O3and 74ppb for NO2. The back-extrapolation method showed a higher degree of disagreement with the nearest monitor approach, inverse-distance weighting interpolation, and the Bayesian maximum entropy model, which were strongly constrained by the sparse monitoring network. The maps showed that the patterns of agreement differed across the postal code areas and the variability depended on the pair of methods compared and the pollutants. For O3, but not NO2, postal areas showing greater disagreement were mostly located near the city centre and along highways, especially in maps involving the back-extrapolation method.
  
  
  
  In view of the substantial differences in daily concentrations of O3and NO2predicted by the different methods, we suggest that analyses of the health effects from air pollution should make use of multiple exposure assessment methods. Although we cannot make any recommendations as to which is the most valid method, models that make use of higher spatially resolved data, such as from dense exposure surveys or from high spatial resolution satellite data, likely provide the most valid estimates.
authors.affiliation: Department of Medicine, McGill University, Montreal, Quebec, Canada; Institut national de sante publique du Quebec (INSPQ), Montreal, Quebec, Canada. Electronic address: stephane.buteau@mail.mcgill.ca.
authors.forename: Stephane
authors.initials: S
authors.lastname: Buteau
authors.affiliation: Department of Civil Engineering, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Marianne
authors.initials: M
authors.lastname: Hatzopoulou
authors.affiliation: Department of Sociology, University of New Brunswick, Fredericton, New Brunswick, Canada; New Brunswick Institute for Research, Data, and Training, Fredericton, New Brunswick, Canada.
authors.forename: Dan L
authors.initials: DL
authors.lastname: Crouse
authors.affiliation: Department of Environmental and Occupational Health, School of Public Health, University of Montreal, Montreal, Quebec, Canada; Public Health Research Institute of the University of Montreal (IRSPUM), Montreal, Quebec, Canada.
authors.forename: Audrey
authors.initials: A
authors.lastname: Smargiassi
authors.affiliation: Population Studies Division, Health Canada, Ottawa, Ontario, Canada.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Burnett
authors.affiliation: Consortium Ouranos, Montreal, Quebec, Canada.
authors.forename: Travis
authors.initials: T
authors.lastname: Logan
authors.affiliation: Department of civil engineering and applied mechanics, McGill University, Montreal, Quebec, Canada.
authors.forename: Laure Deville
authors.initials: LD
authors.lastname: Cavellin
authors.affiliation: Department of Medicine, McGill University, Montreal, Quebec, Canada; Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Goldberg
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D008962:Models, Theoretical; D009585:Nitrogen Dioxide / Q000032:analysis*; D010126:Ozone / Q000032:analysis*; D011792:Quebec; D062206:Spatial Analysis; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D010126:Ozone; D009585:Nitrogen Dioxide
keywords: Ambient air pollution; Exposure assessment; Interpolation; Nitrogen dioxide; Ozone; Spatiotemporal