title: Microbialhara-kiri: Exploiting lysosomal cell death in malaria parasites.
abstract: The antimalarial drug chloroquine (CQ) has been sidelined in the fight againstfalciparummalaria due to wide-spread CQ resistance. Replacement drugs like sulfadoxine, pyrimethamine and mefloquine have also since been surpassed with the evolution of multi-drug resistant parasites. Even the currently recommended artemisinin-based combination therapies show signs of compromise due to the recent spread of artemisinin delayed-clearance parasites. Though there have been promising breakthroughs in the pursuit of new effective antimalarials, the development and strategic deployment of such novel chemical entities takes time. We therefore argue that there is a crucial need to re-examine the usefulness of 'outdated' drugs like chloroquine, and explore if they might be effective alternative therapies in the interim. We suggest that a novel parasite cell death (pCD) pathway may be exploited through the reformulation of CQ to address this need.
authors.affiliation: Department of Microbiology, National University of Singapore, Singapore. ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Jun-Hong
authors.initials: JH
authors.lastname: Ch'ng
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Ursing
authors.affiliation: Department of Microbiology, National University of Singapore, Singapore.
authors.forename: Kevin Shyong-Wei
authors.initials: KS
authors.lastname: Tan
keywords: Plasmodium falciparum; chloroquine; digestive vacuole; lysosomal cell death; malaria; programmed cell death; repositioning