title: Oxidative Stress Function in Women over 40 Years of Age, Considering Their Lifestyle.
abstract: Aging is dependent on biological processes that determine the aging of the organism at the cellular level. The Oxidative Stress Theory of Aging might explain some of the age-related changes in cell macromolecules. Moreover, exposome and lifestyle may also induce changes in cell damage induced by oxidative stress. The aim of the present study was to analyze the related redox changes in lymphocyte function of healthy women over 40 years old. Three groups: younger (YG: 40-49 years), middle aged (MAG: 50-59 years), and older (OG: ≥60 years) were evaluated on anthropometric variables, blood pressure, cardiovascular fitness, lifestyle habits, perceived stress, DNA damage, malondialdehyde, catalase activity, and total antioxidant capacity. Physical activity and cardiovascular fitness were significantly higher in YG and MAG as compared to the OG. Systolic blood pressure increased significantly with group age. Frequency and total amount of alcohol intake were lower in the OG and higher in the MAG. No significant differences were observed between the three groups in oxidative stress parameters. Only alcohol consumption was associated with the higher DNA FPG-sensitive sites, and only in the YG (p< 0.05). Healthy lifestyle is critical to avoiding major ailments associated with aging. This may be inferred from the lack of significant differences in the various oxidative stress parameters measured in the healthy women over the age of 40 who took part in the study. Conscious lifestyle behaviors (decrease in alcohol and smoking habits) could have impaired the expected age-related oxidative stress increase.
authors.affiliation: Research Centre in Sports, Health and Human Development, Vila Real, Portugal; University of Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors.forename: Maria Paula
authors.initials: MP
authors.lastname: Gonçalves Mota
authors.affiliation: Research Centre in Sports, Health and Human Development, Vila Real, Portugal; Faculty Metodista Granbery, Juiz de Fora, Brazil.
authors.forename: Zirlene
authors.initials: Z
authors.lastname: Santos
authors.affiliation: Research Centre in Sports, Health and Human Development, Vila Real, Portugal; University of Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors.forename: Jorge
authors.initials: J
authors.lastname: Soares
authors.affiliation: Research Centre in Sports, Health and Human Development, Vila Real, Portugal; Department of Sport Science, School of Education, Research Centre in Education, Polytechnic Institute of Setubal, Setubal, Portugal.
authors.forename: Ana
authors.initials: A
authors.lastname: Pereira
authors.affiliation: Research Centre in Sports, Health and Human Development, Vila Real, Portugal; University of Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors.forename: Sandra
authors.initials: S
authors.lastname: Fonseca
authors.affiliation: University of Trás-os-Montes e Alto Douro, Vila Real, Portugal; Centre for Research and Technology of Agro-Environmental and Biological Sciences, Vila Real, Portugal.
authors.forename: Francisco
authors.initials: F
authors.lastname: Peixoto
authors.affiliation: University of Trás-os-Montes e Alto Douro, Vila Real, Portugal; Animal and Veterinary Research Centre, Vila Real, Portugal.
authors.forename: Isabel
authors.initials: I
authors.lastname: Gaivão
authors.affiliation: University of Trás-os-Montes e Alto Douro, Vila Real, Portugal; Chemistry Research Centre, Vila Real, Portugal.
authors.forename: Maria
authors.initials: M
authors.lastname: Oliveira
keywords: DNA damage; aging; cardiovascular fitness; lifestyle; lipid peroxidation; oxidative stress