title: Antidepressant-Like Effect of 1α-Hydroxyvitamin D3on Mice in the Forced Swimming Test.
abstract: We examined the effect of 1α-hydroxyvitamin D3[1α(OH)D3] on mice in the forced swimming test. Intragastric administration of 1.0 μg/kg of 1α(OH)D3reduced immobility time in the forced swimming test. At all concentrations tested (0.5, 1.0, 2.0 μg/kg), 1α(OH)D3had no effect on locomotor activity, compared with controls. These results suggest that 1α(OH)D3may have antidepressant-like activity.
authors.affiliation: Department of Physical Therapy, School of Health Care and Social Welfare, KIBI International University.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawaura
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Tanida
authors.forename: Junichi
authors.initials: J
authors.lastname: Akiyama
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Mizutani
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Harada
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Morishita
authors.forename: Shigeki
authors.initials: S
authors.lastname: Inoue
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kano
authors.forename: Toshio
authors.initials: T
authors.lastname: Okano
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeda
mesh_terms: D000818:Animals; D000928:Antidepressive Agents; D004195:Disease Models, Animal; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D006887:Hydroxycholecalciferols; C008088:alfacalcidol