title: Association between disease activity and quality of life in ulcerative colitis: Results from the CRONICA-UC study.
abstract: In ulcerative colitis (UC), the main goals of treatment are to control disease activity and normalize health-related quality of life (HRQoL). In this study, we explored the relationship between disease activity (measured using the Simple Clinical Colitis Activity Index [SCCAI]) and patient HRQoL (measured using the EuroQoL [EQ]-5D-5L).
  
  
  
  A total of 199 patients with UC were followed for 6 months. At months 3 and 6, patients completed an online SCCAI. Within 2 days of completing the SCCAI, patients completed an at-clinic EQ-5D-5L questionnaire and the treating gastroenterologist completed the SCCAI.
  
  
  
  A consistent and approximately linear relationship was identified between patient HRQoL and patient-completed and physician-completed SCCAIs. A lower SCCAI score corresponded to a higher EQ-5D-5L index value. Correlation between EQ-5D-5L index values and patient-completed online SCCAIs was moderate (ρ -0.49; P < 0.001) and similar to that between EQ-5D-5L index values and physician-completed SCCAIs (ρ -0.53; P < 0.001). A decrease in the EQ-5D-5L index was already observed at an SCCAI score of 2, commonly regarded as remission. A 1-point increase in the patient SCCAI corresponded to an average change of -0.027 (standard deviation, -0.032 to -0.022) in the EQ-5D-5L index, whereas a 1-point increase in the physician SCCAI corresponded to an average change of -0.030 (standard deviation, -0.036 to -0.025).
  
  
  
  Health-related quality of life measured using the EQ-5D-5L questionnaire is proportionally related to disease activity in patients with UC. In line with the treat-to-target objective in UC, complete control of all symptoms is required to achieve optimal improvement in patient HRQoL.
authors.affiliation: Department of Gastroenterology, Hospital Clínic Barcelona, IDIBAPS, Center for Biomedical Research in Network of Liver and Digestive Diseases (CIBERehd), Barcelona, Spain.
authors.forename: Julián
authors.initials: J
authors.lastname: Panés
authors.affiliation: Gastroenterology Unit, Hospital Universitari Germans Trias i Pujol (Badalona), Center for Biomedical Research in Network of Liver and Digestive Diseases (CIBERehd), Badalona, Spain.
authors.forename: Eugeni
authors.initials: E
authors.lastname: Domènech
authors.affiliation: Department of Gastroenterology, La Fe University and Polytechnic Hospital, Center for Biomedical Research in the Network of Liver and Digestive Diseases (CIBERehd), Valencia, Spain.
authors.forename: Marian
authors.initials: M
authors.lastname: Aguas Peris
authors.affiliation: Department of Gastroenterology, La Fe University and Polytechnic Hospital, Center for Biomedical Research in the Network of Liver and Digestive Diseases (CIBERehd), Valencia, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Nos
authors.affiliation: Department of Gastroenterology, Inflammatory Bowel Disease Unit, Central University Hospital of Asturias, Oviedo, Spain.
authors.forename: Sabino
authors.initials: S
authors.lastname: Riestra
authors.affiliation: Medical Affairs Department, Merck Sharp & Dohme Spain, Madrid, Spain.
authors.forename: Berta
authors.initials: B
authors.lastname: Juliá de Páramo
authors.affiliation: Medical Affairs Department, Merck Sharp & Dohme Spain, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Cea-Calvo
authors.affiliation: Medical Affairs Department, Merck Sharp & Dohme Spain, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Romero
authors.affiliation: Gastroenterology Unit, Gregorio Marañón General University Hospital, Gregorio Marañón Institute of Health Research (IiSGM), Madrid, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Marín-Jiménez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003093:Colitis, Ulcerative / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors; D055815:Young Adult
keywords: disease activity; health-related quality of life; questionnaire; symptoms; ulcerative colitis