title: Taming a Vinyl Cation with a Simple Al(OTf)3Catalyst To Promote C-C Bond Cleavage.
abstract: A detailed mechanistic investigation identified the stepwise nature of the 1,3-aryl shift, which enables our recently disclosed Al3+-catalyzed insertion of unactivated alkynes into the sp2-sp3C-C bond of benzyl alcohols. The selectivity for the rearranged product was found to be induced by the continued coordination of the aluminum catalyst to the rearranging species, which is encouraged by a reversible background reaction. This participation of the catalyst beyond the ionization step is unique in the realm of carbocation driven reactions and opens up the possibility of a catalyst-induced chiral induction in the future. Furthermore, the study represents a rare example of detailed mechanistic analysis of a reaction with a product selectivity that changes with increasing conversion.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Meike
authors.initials: M
authors.lastname: Niggemann
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Liang
authors.initials: L
authors.lastname: Fu
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
authors.forename: Helena
authors.initials: H
authors.lastname: Damsen
keywords: aluminum catalysis; carbon shift; cation rearrangement; transition-metal free; vinyl cation