title: Introduction to Lymphocyte Trafficking in Disease.
abstract: Lymphocytes are the key effector cells of the adaptive immune response but are also implicated in the development of chronic inflammatory diseases such as type 2 diabetes, cardiovascular disease, inflammatory bowel disease, and allergy. In order to understand the mechanisms responsible for the global increase in such debilitating conditions it is vital to appreciate the complexity of immune cell trafficking into tissue under normal and inflamed conditions. In this chapter we introduce the mechanisms of immune cell recruitment into tissue and highlight how these processes have been targeted by new therapeutic entities based on blocking integrin or chemokine function.
authors.affiliation: Centre for Liver Research, Immunity and Immunotherapy, Institute of Biomedical Research, University of Birmingham, Wolfson Drive, Edgbaston, Birmingham, West Midlands, B15 2TT, UK. p.f.lalor@bham.ac.uk.
authors.forename: Patricia F
authors.initials: PF
authors.lastname: Lalor
authors.affiliation: Department of Cellular Pathology, Cheltenham General Hospital, Sandford Road, Cheltenham, Gloucestershire, GL53 7AN, UK.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Hepburn
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D018925:Chemokines / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*
chemical_list: D018925:Chemokines
keywords: Imaging; Inflammation; Lymphocyte; Migration; Therapy