title: Gastrointestinal manifestations of melioidosis: A single center experience.
abstract: Melioidosis, being increasing, is reported from India. Gastrointestinal manifestations are typically reported as unusual cause of liver and/or splenic abscess. We aimed to describe various gastrointestinal manifestation of melioidosis in the present study. We retrospectively collected data of culture positive melioidosis cases from hospital database during August 2014-October 2016 at Asian Institute of Gastroenterology, Hyderabad. A total of nine culture positive cases (8 male) of melioidosis with median age of 40 years (range 23-66) were analyzed. Median duration of symptoms was 45 days. Two patients were being treated as tuberculosis. Three patients presented with liver abscess with two of them having simultaneous splenic abscess, and one had prostatic abscess. Three patients (43%) with history of acute pancreatitis had infected pancreatic collection, and one patient had left empyema with splenic abscess. One patient had wound infection with left lower limb cellulitis, presented as acute in chronic liver failure and another as spontaneous bacterial peritonitis (SBP). Diabetes and/or alcoholism was present in all patients. Seven patients had disseminated organ involvement. Seven patients underwent percutaneous intervention for drainage of abscess. Induction therapy as ceftazidime (n=4) or meropenem (n=5) followed by continuation therapy as oral cotrimoxazole (n=6) and doxycycline (n=1) was given. Six patients completed therapy and asymptomatic at end of follow up. Two patients died in the study period. One patient died due to acute-on-chronic liver failure (ACLF) with acute kidney injury and the other due to cardiac failure. One patient with SBP had lost to follow up. Apart from being unusual cause of liver/splenic abscess, melioidosis can present with infection of pancreatic collection, SBP, and infection in a compensated cirrhosis which can precipitate ACLF. Early recognition and specific therapy can improve prognosis.
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India. docnits13@gmail.com.
authors.forename: Nitin
authors.identifier: http://orcid.org/0000-0002-3469-0164
authors.initials: N
authors.lastname: Jagtap
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.
authors.forename: Harshal
authors.initials: H
authors.lastname: Shah
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.
authors.forename: Anuradha
authors.initials: A
authors.lastname: Kancharla
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.
authors.forename: Manu
authors.initials: M
authors.lastname: Tandan
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.
authors.forename: Partha
authors.initials: P
authors.lastname: Pal
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.
authors.forename: Sundeep
authors.initials: S
authors.lastname: Lakhtakia
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.
authors.forename: Mohan
authors.initials: M
authors.lastname: Ramchandani
authors.affiliation: Department of Gastroenterology, Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.
authors.forename: D N
authors.initials: DN
authors.lastname: Reddy
mesh_terms: D000038:Abscess / Q000209:etiology*; D065290:Acute-On-Chronic Liver Failure / Q000209:etiology; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002481:Cellulitis / Q000209:etiology; D016208:Databases, Factual; D004322:Drainage; D005260:Female; D006801:Humans; D007194:India; D008100:Liver Abscess / Q000209:etiology* / Q000628:therapy; D008297:Male; D008554:Melioidosis / Q000150:complications*; D008875:Middle Aged; D010195:Pancreatitis / Q000209:etiology; D010538:Peritonitis / Q000209:etiology; D011469:Prostatic Diseases / Q000209:etiology; D012189:Retrospective Studies; D013158:Splenic Diseases / Q000209:etiology* / Q000628:therapy; D014946:Wound Infection / Q000209:etiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Acute-on-chronic liver failure; Melioidosis; Pancreatitis; Spontaneous bacterial peritonitis