title: Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.
abstract: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders with notable factor of dysfunction in cholinergic system. Low ACh level can be observed in the pathogenesis of AD. Several AChE inhibitors have already been used for clinical treatments. However, other than normal conditions, ACh is mostly hydrolyzed by BuChE in progressed AD. Account for an increased level of BuChE and decreased level of AChE in the late stage of AD, development of selective BuChE inhibitor is of vital importance. Up till now, compounds with various scaffolds have been discovered to selectively inhibit BuChE. Different effective anti-BuChE molecules are concluded in this review.
authors.affiliation: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: sunhaopeng@163.com.
authors.forename: Haopeng
authors.initials: H
authors.lastname: Sun
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D002091:Butyrylcholinesterase / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D006801:Humans
chemical_list: D002800:Cholinesterase Inhibitors; D002091:Butyrylcholinesterase
keywords: Alzheimer's disease; Selective butyrylcholinesterase inhibitors