title: Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?
abstract: Thanks to their immune properties, the mesenchymal stem cells (MSC) are a promising source for cell therapy. Current clinical trials show that MSC administrated to patients can treat different diseases (graft-versus-host disease (GVHD), liver cirrhosis, systemic lupus, erythematosus, rheumatoid arthritis, type I diabetes…). In this case, the most common mode of cell administration is the intravenous injection, and the hemodynamic environment of cells induced by blood circulation could interfere on their behavior during the migration and homing towards the injured site. After a brief review of the mechanobiology concept, this paper will help in understanding how the mechanical environment could interact with MSC behavior once they are injected to patient in cell-based treatment.
authors.affiliation: UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Biopôle, 54500 Vandœuvre-lès-Nancy, France.|Université de Lorraine, 54000 Nancy, France.|FR3209 CNRS BMCT - Bio-Ingénierie Moléculaire Cellulaire et Thérapeutique, Faculté de Médecine, F-54505 Vandœuvre-lès-Nancy, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Huselstein
authors.affiliation: Université de Lorraine, 54000 Nancy, France.|UMR 7563 CNRS-Université de Lorraine, LEMTA, Vandœuvre-lès-Nancy, France.
authors.forename: R
authors.initials: R
authors.lastname: Rahouadj
authors.affiliation: UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Biopôle, 54500 Vandœuvre-lès-Nancy, France.|Université de Lorraine, 54000 Nancy, France.|FR3209 CNRS BMCT - Bio-Ingénierie Moléculaire Cellulaire et Thérapeutique, Faculté de Médecine, F-54505 Vandœuvre-lès-Nancy, France.
authors.forename: N
authors.initials: N
authors.lastname: de Isla
authors.affiliation: UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Biopôle, 54500 Vandœuvre-lès-Nancy, France.|Université de Lorraine, 54000 Nancy, France.|FR3209 CNRS BMCT - Bio-Ingénierie Moléculaire Cellulaire et Thérapeutique, Faculté de Médecine, F-54505 Vandœuvre-lès-Nancy, France.|CHU de Nancy, Unité de Thérapie Cellulaire, banque de Tissus, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: D
authors.initials: D
authors.lastname: Bensoussan
authors.affiliation: UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Biopôle, 54500 Vandœuvre-lès-Nancy, France.|Université de Lorraine, 54000 Nancy, France.|FR3209 CNRS BMCT - Bio-Ingénierie Moléculaire Cellulaire et Thérapeutique, Faculté de Médecine, F-54505 Vandœuvre-lès-Nancy, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Stoltz
authors.affiliation: Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Y P
authors.initials: YP
authors.lastname: Li
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001703:Biophysics; D002465:Cell Movement; D002633:Chemotaxis; D006439:Hemodynamics; D006801:Humans; D007275:Injections, Intravenous; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D057705:Transendothelial and Transepithelial Migration
keywords: Mesenchymal stem cells; cell-based treatment; homing; mechanobiology; migration