title: Tropical arthritogenic alphaviruses.
abstract: Tropical alphaviruses have special tropism for bone and joint tissue. Patients can develop chronic rheumatic disorders similar to rheumatoid arthritis and ankylosing spondylitis. The prototype is Chikungunya virus, although other lesser known viruses in our environment such as Sindbis, Ross River, Mayaro, O'nyong nyong and Barmah Forest viruses have the potential to be sped through vectors and cause chronic rheumatic disease. International population movements have increased the numbers of patients diagnosed with these tropical viruses in areas in which they are not endemic. Since they can leave persistent symptoms and affect the quality of life of the patients, it is important that we be aware of them. Changes in ecosystems have favored the expansion of competent mosquitoes, making fears of local transmission in southern Europe a reality. The objective of this review is to provide a clinical approach to the different arthritogenic tropical alphaviruses, especially those in which chronic rheumatic disease is more frequent.
authors.affiliation: Unidad de Referencia Nacional para Enfermedades Tropicales, Servicio de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Carla-Ruth
authors.initials: CR
authors.lastname: Mejía
authors.affiliation: Unidad de Referencia Nacional para Enfermedades Tropicales, Servicio de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address: rogelio.lopezvelez@salud.madrid.org.
authors.forename: Rogelio
authors.initials: R
authors.lastname: López-Vélez
mesh_terms: D018354:Alphavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D014943:Global Health; D006801:Humans; D012216:Rheumatic Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy
keywords: Alfavirus; Alphavirus; Artritis crónica; Artritis infecciosa; Chronic arthritis; Infectious arthritis