title: Successful treatment ofListeria monocytogenesprosthetic valve endocarditis using rifampicin and benzylpenicillin in combination with valve replacement.
abstract: Introduction.Listeria monocytogenesis an uncommon cause of prosthetic valve endocarditis (PVE). Recommended antimicrobial therapy typically includes intravenous β-lactams with or without synergistic aminoglycosides.In vitrostudies have previously identified antagonism when rifampicin has been used in combination with β-lactams. However,in vivodata of rifampicin use are limited despite its enhanced anti-biofilm activity.Case presentation.A 63-year-old male presented with fever and back pain.L. monocytogenesbacteraemia and bioprosthetic aortic valve endocarditis was confirmed, along with spinal discitis and osteomyelitis. He was successfully treated with benzylpenicillin and rifampicin, in conjunction with valve replacement.Conclusion.Rifampicin remains an alternate agent to use, when there are contraindications to traditional aminoglycoside therapy. Further data on rifampicin use inL. monocytogenesPVE are awaited.
authors.affiliation: Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital , Westmead, New South Wales , Australia.
authors.forename: Tasnim
authors.initials: T
authors.lastname: Hasan
authors.affiliation: Department of Cardiology, Westmead Hospital , Westmead, New South Wales , Australia.
authors.forename: William
authors.initials: W
authors.lastname: Chik
authors.affiliation: Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia; Centre for Research Excellence in Critical Infections, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia.
authors.forename: Sharon
authors.initials: S
authors.lastname: Chen
authors.affiliation: Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia; Centre for Research Excellence in Critical Infections, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia.
authors.forename: Jen
authors.initials: J
authors.lastname: Kok
keywords: Listeria; endocarditis; prosthetic valve; rifampicin