title: Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders.
abstract: Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients with major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ). However, whether the lifespan trajectory of gyrification over the brain is altered in patients diagnosed with major psychiatric disorders is still unknown. In this study, we investigated the trajectories of gyrification in three independent cohorts based on structural brain images of 881 subjects from age 4 to 83. We discovered that the trajectory of gyrification during normal development and aging was not linear and could be modeled with a logarithmic function. We also found that the gyrification trajectories of patients with MDD, BD and SCZ were deviated from the healthy one during adulthood, indicating altered aging in the brain of these patients.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA. CloudBoCao@gmail.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Cao
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Benson
authors.initials: B
authors.lastname: Mwangi
authors.affiliation: Graduation Program in Psychiatry and Laboratory of Molecular Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Ives Cavalcante
authors.initials: IC
authors.lastname: Passos
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Mon-Ju
authors.initials: MJ
authors.lastname: Wu
authors.affiliation: Department of Neurology, The University of Texas Science Center at Houston, Houston, Texas, USA.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Keser
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Giovana B
authors.initials: GB
authors.lastname: Zunta-Soares
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Dianping
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Diagnostic and Interventional Imaging, The University of Texas Science Center at Houston, Houston, Texas, USA.
authors.forename: Khader M
authors.initials: KM
authors.lastname: Hasan
authors.affiliation: Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Jair C
authors.initials: JC
authors.lastname: Soares
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003710:Demography; D003865:Major Depressive Disorder / Q000473:pathology*; D005260:Female; D006801:Humans; D008136:Longevity; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000473:pathology*; D055815:Young Adult