title: The clinical research of Thinprep Cytology Test (TCT) combined with HPV-DNA detection in screening cervical cancer.
abstract: Our objective is to explore the clinical value of thinprep cytologic test (TCT) combined with HPV-DNA detection in screening cervical cancer. 420 cervical cancer patients admitted in our hospital between April, 2011-April, 2014 were selected. All patients received TCT and HPV-DNA detection, and cervical tissue biopsy was used to confirm the diagnosis. TCT screening results showed that there were 175 patients were &gt;ASCUS and the positive rate was 41.7%, histopathological screening showed that there were 199 patients were ≥cervical intraepithelial neoplasia (CIN) I and the positive rate was 47.4%. HPV-DNA detection showed 180 patients were positive which was 42.9%, and the positive rate of HPV-DNA detection was increased as the disease severity increased. The sensitivity of TCT combined with HPV-DNA detection was higher than single TCT or HPV-DNA, however the specificity was relatively low, and the positive predictive value and negative predictive value were higher which were similar to pathological results. TCT combined with HPV-DNA detection has high sensitivity and accuracy in screening cervical cancer, which is worthy of clinical application.
authors.affiliation: Department of Obstetrics and Gynecology, Yidu Central Hospital of Weifang, Weifang 262500, Shandong, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Yidu Central Hospital of Weifang, Weifang 262500, Shandong, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedic, Yidu Central Hospital of Weifang, Weifang 262500, Shandong, China.
authors.forename: G
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Department of Obstetrics and Gynecology, Yidu Central Hospital of Weifang, Weifang 262500, Shandong, China.
authors.forename: L
authors.initials: L
authors.lastname: Che
authors.affiliation: Department of Obstetrics and Gynecology, Yidu Central Hospital of Weifang, Weifang 262500, Shandong, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedic, Yidu Central Hospital of Weifang, Weifang 262500, Shandong, China.
authors.forename: J
authors.initials: J
authors.lastname: Fang
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D003581:Cytodiagnosis / Q000379:methods*; D004279:DNA, Viral / Q000235:genetics*; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics* / Q000502:physiology; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000821:virology
chemical_list: D004279:DNA, Viral
keywords: Cervical cancer screening; Clinical value.; HPV-DNA detection; TCT