title: Examples of multiscale and multiphysics numerical modeling of biological tissues.
abstract: Predictive theoretical-numerical modeling of the behavior and evolution of biological tissue is a difficult task since many of the required knowledge tools (experimental, theoretical and numerical) are still not well understood. We present here some methodologies and results specific to multiscale and multiphysics numerical modeling of biological tissues applied to the predictive behavior of cortical veins depending on their local constituents' microstructure and for bone remodeling and reconstruction as a function of the local mechanobiology. Although further work is required to improve the accuracy of the developed models, the proposed approaches highlight their potential usefulness for understanding the mechanical-biological couplings, short and long term predictions of biological evolutions as well as possible further transfer to medical applications.
authors.affiliation: ICube Laboratory, University of Strasbourg, CNRS, 2 rue Boussingault, 67000 Strasbourg, France.|International Center MEMOCS, University del Aquila, Palazzo Caetani, Cisterna di Latina, Italy.
authors.forename: Daniel
authors.initials: D
authors.lastname: George
authors.affiliation: ICube Laboratory, University of Strasbourg, CNRS, 2 rue Boussingault, 67000 Strasbourg, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Spingarn
authors.affiliation: Service of Maxillo-Facial Surgery and Stomatology, Strasbourg University Hospital, 1 place de l'Hôpital, 67000 Strasbourg, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Dissaux
authors.affiliation: ICube Laboratory, University of Strasbourg, CNRS, 2 rue Boussingault, 67000 Strasbourg, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Nierenberger
authors.affiliation: The French University of Egypt, El Chourouq city, Cairo, Egypt.
authors.forename: Ranya Abdel
authors.initials: RA
authors.lastname: Rahman
authors.affiliation: ICube Laboratory, University of Strasbourg, CNRS, 2 rue Boussingault, 67000 Strasbourg, France.|International Center MEMOCS, University del Aquila, Palazzo Caetani, Cisterna di Latina, Italy.
authors.forename: Yves
authors.initials: Y
authors.lastname: Rémond
mesh_terms: D001696:Biomechanical Phenomena; D016723:Bone Remodeling; D001842:Bone and Bones / Q000033:anatomy & histology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000098:blood supply*; D003198:Computer Simulation; D006801:Humans; D008953:Models, Anatomic; D008954:Models, Biological; D013314:Stress, Mechanical; D014680:Veins / Q000033:anatomy & histology / Q000502:physiology*
keywords: Multiscale; bone; homogenization; mechanobiology; numerical modeling; vein