title: Can Ligands of Different Functional Types Induce Distinct Dynamics in G Protein-Coupled Receptors?
abstract: G Protein-Coupled Receptors (GPCRs) are the most common therapeutic targets for drug discovery by the pharmaceutical industries. Since 2007, several three-dimensional X-ray crystallographic structures of ligand-activated GPCRs have been determined in their agonist-bound or inverse agonist-bound states, providing a wealth of fundamental resources for the investigation of the atomic-level mechanism of receptor activation and deactivation. A number of computational methods, such as conventional and enhanced sampling Molecular Dynamic (MD) simulations have been applied to investigate the receptor dynamics bound with ligands of different functional types (i.e., agonist and inverse agonist). In this article, we reviewed recent efforts in characterizing the dynamical activation and deactivation mechanisms of GPCRs induced by different functional types of ligands.
authors.affiliation: School of Pharmacy, National Taiwan University, Taipei, Taiwan.
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Chen
authors.affiliation: School of Pharmacy, National Taiwan University, Taipei, Taiwan.|Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.|Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.|College of Engineering Sciences, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Jung-Hsin
authors.initials: JH
authors.lastname: Lin
mesh_terms: D006801:Humans; D008024:Ligands; D056004:Molecular Dynamics Simulation; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled
keywords: Agonist; Conformational selection; Enhanced sampling; G Protein-coupled receptor; Induced fit; Inverse agonist; Ligand; Molecular dynamics simulation; Neutral antagonist; Receptor activation/deactivation