title: Graphene Multielectrode Arrays as a Versatile Tool for Extracellular Measurements.
abstract: Graphene multielectrode arrays (GMEAs) presented in this work are used for cardio and neuronal extracellular recordings. The advantages of the graphene as a part of the multielectrode arrays are numerous: from a general flexibility and biocompatibility to the unique electronic properties of graphene. The devices used for extensive in vitro studies of a cardiac-like cell line and cortical neuronal networks show excellent ability to extracellularly detect action potentials with signal to noise ratios in the range of 45 ± 22 for HL-1 cells and 48 ± 26 for spontaneous bursting/spiking neuronal activity. Complex neuronal bursting activity patterns as well as a variety of characteristic shapes of HL-1 action potentials are recorded with the GMEAs. This paper illustrates that the potential applications of the GMEAs in biological and medical research are still numerous and diverse.
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425, Jülich, Germany.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Kireev
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425, Jülich, Germany.
authors.forename: Silke
authors.identifier: http://orcid.org/0000-0002-7713-6948
authors.initials: S
authors.lastname: Seyock
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425, Jülich, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Lewen
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425, Jülich, Germany.
authors.forename: Vanessa
authors.identifier: http://orcid.org/0000-0001-7228-2922
authors.initials: V
authors.lastname: Maybeck
authors.affiliation: Neuroelectronics, Munich Schnool of Bioengineering, Department of Electrical and Computer Engineering, Technical University of Munich (TUM) & BCCN Munich, Boltzmannstr. 11, 85748, Garching, Germany.
authors.forename: Bernhard
authors.identifier: http://orcid.org/0000-0003-4438-3755
authors.initials: B
authors.lastname: Wolfrum
authors.affiliation: Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425, Jülich, Germany.
authors.forename: Andreas
authors.identifier: http://orcid.org/0000-0001-6143-2702
authors.initials: A
authors.lastname: Offenhäusser
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002478:Cells, Cultured; D058266:Dielectric Spectroscopy; D005110:Extracellular Space / Q000378:metabolism*; D006108:Graphite / Q000737:chemistry*; D051379:Mice; D008839:Microelectrodes; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D017208:Rats, Wistar; D059629:Signal-To-Noise Ratio
chemical_list: D006108:Graphite
keywords: GMEA; extracellular recordings; graphene; neuron