title: Short article: Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients admitted for acute decompensation of liver cirrhosis.
abstract: BACKGROUND
  Vasopressin receptor-mediated vasoconstriction is considered to be involved in the pathogenesis of organ failure in acute-on-chronic liver failure (ACLF).
  
  
  METHODS
  We studied the association between six single nucleotide polymorphisms (SNPs) of the vasopressin 1a receptor gene and the development of organ failure in 826 patients admitted for acute decompensation of liver cirrhosis (n=641) or ACLF (n=185).
  
  
  RESULTS
  No associations were found for SNPs with the presence of circulatory or renal failure. A C>T mutation in SNP rs7308855 and a T>A mutation in SNP rs7298346 showed an association with the presence of coagulation failure in the entire population (n=61, P=0.024 and 0.060, respectively) and in the subgroup of patients with ACLF (n=44, P=0.081 and 0.056, respectively).
  
  
  CONCLUSIONS
  Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and ACLF.
authors.affiliation: aDepartment of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, The Netherlands bData Management Center, Hospital Clinic de Barcelona, Barcelona, Spain cLiver Unit, Hospital Clínic de Barcelona, Barcelona, Spain dLiver Unit, Hospital Vall d'Hebron Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain eLiver Failure Group, UCL Institute for Liver and Digestive Health, UCL Medical School, Royal Free Hospital, London, UK fDepartment of Gastroenterology-Hepatology, St Vincent's University Hospital, Dublin, Ireland gInternal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Annarein J C
authors.initials: AJ
authors.lastname: Kerbert
authors.forename: Jelte J
authors.initials: JJ
authors.lastname: Schaapman
authors.forename: Johan J
authors.initials: JJ
authors.lastname: van der Reijden
authors.forename: Àlex
authors.initials: À
authors.lastname: Amorós Navarro
authors.forename: Aiden
authors.initials: A
authors.lastname: McCormick
authors.forename: Bart
authors.initials: B
authors.lastname: van Hoek
authors.forename: Vicente
authors.initials: V
authors.lastname: Arroyo
authors.forename: Pere
authors.initials: P
authors.lastname: Ginès
authors.forename: Rajiv
authors.initials: R
authors.lastname: Jalan
authors.forename: Victor
authors.initials: V
authors.lastname: Vargas
authors.forename: Rudolf
authors.initials: R
authors.lastname: Stauber
authors.forename: Hein W
authors.initials: HW
authors.lastname: Verspaget
authors.forename: Minneke J
authors.initials: MJ
authors.lastname: Coenraad
mesh_terms: D065290:Acute-On-Chronic Liver Failure / Q000150:complications / Q000235:genetics; D000328:Adult; D000368:Aged; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D060005:Genotyping Techniques; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D017483:Receptors, Vasopressin / Q000235:genetics*
chemical_list: D017483:Receptors, Vasopressin