title: Associations of NQO1 C609T and NQO1 C465T polymorphisms with acute leukemia risk: a PRISMA-compliant meta-analysis.
abstract: OBJECTIVE
  The NAD(P)H:quinone oxidoreductase (NQO1) C609T and C465T polymorphisms have been widely thought to be associated with the risk of acute leukemia (AL) in recent years, but the correlations are still unclear. A meta-analysis is generally acknowledged as one of the best methods for secondary research, and so it was applied in this study with the aim of elucidating how the NQO1 C609T and C465T polymorphisms are related to the risk of AL.
  
  
  METHODS
  Relevant studies were searched in the PubMed, EMBASE, CNKI, and Wanfang databases, and the obtained data were analyzed using Stata (version 12.1). The allele-contrast model was applied, and odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate relationship strengths. Meta-regression was used to identify sources of heterogeneity, and subgroup analyses were conducted. Publication bias was analyzed using funnel plots, with the trim-and-fill method used to analyze the effect of publication bias on pooled results. In addition, sensitivity analysis, the fail-safe number method, and cumulative analysis by publication year were performed to measure the stability of the obtained results.
  
  
  RESULTS
  This meta-analysis included 28 relevant studies involving 5,953 patients and 8,667 controls. Overall, the C609T polymorphism was associated with the risk of acute lymphoblastic leukemia (ALL; OR =1.18, 95% CI =1.00-1.39,P=0.05). Meanwhile, race was found to be a potential source of heterogeneity for the relationship between the C609T polymorphism and acute myeloid leukemia (AML) risk, and the subgroup analysis identified the C609T polymorphism as a risk factor for AML in Asians (OR =1.34, 95% CI =1.03-1.74,P=0.03). The number of studies about C465T polymorphism was too small to pool the data.
  
  
  CONCLUSIONS
  There are increased risks of ALL in all subjects and of AML in Asians for carriers of the NQO1 C609T polymorphism. Further studies are needed to verify the associations of the C465T polymorphism with the risk of AL.
authors.affiliation: Clinical Research Center.
authors.forename: Hairong
authors.initials: H
authors.lastname: He
authors.affiliation: Clinical Research Center; College of Pharmacy, Xi'an Medical University.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Dialysis Department of Nephrology Hospital.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Clinical Research Center.
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Zhai
authors.affiliation: Clinical Research Center.
authors.forename: Fan
authors.initials: F
authors.lastname: Gao
authors.affiliation: School of Public Health, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Clinical Research Center.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
keywords: ALL; AML; NQO1; polymorphism