title: Dopamine as a potential rescue therapy for refractory protein-losing enteropathy in Fontan-palliated patients.
abstract: PLE is an important cause of morbidity and mortality in patients who have undergone Fontan palliation. While multiple PLE therapies have been reported, none has proved consistently effective. Patients who do not respond to "standard" PLE therapies face poor long-term outcomes. We report here a significant response to dopamine infusion in three patients with chronic, refractory PLE. We hypothesize that this response may be at least partially due to a dopamine effect on lymphatic receptors rather than to an augmentation of cardiac output.
authors.affiliation: Division of Pediatric Cardiology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.
authors.forename: Joshua M
authors.identifier: http://orcid.org/0000-0001-6161-7651
authors.initials: JM
authors.lastname: Friedland-Little
authors.affiliation: Division of Pediatric Cardiology, Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Gajarski
authors.affiliation: Division of Pediatric Cardiology, Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Kurt R
authors.initials: KR
authors.lastname: Schumacher
mesh_terms: D000293:Adolescent; D002908:Chronic Disease; D004298:Dopamine / Q000627:therapeutic use*; D015259:Dopamine Agents / Q000627:therapeutic use*; D005260:Female; D018729:Fontan Procedure; D006801:Humans; D008297:Male; D010166:Palliative Care; D011183:Postoperative Complications / Q000188:drug therapy*; D011504:Protein-Losing Enteropathies / Q000188:drug therapy* / Q000209:etiology; D055815:Young Adult
chemical_list: D015259:Dopamine Agents; D004298:Dopamine
keywords: dopamine; fontan operation; heart transplantation; protein-losing enteropathy