title: Proteomic Approaches to Enable Point-of-Care Testing and Personalized Medicine for Psychiatric Disorders.
abstract: This chapter describes how innovations that are driven by proteomic biomarker techniques can facilitate earlier and better treatment of patients who suffer from psychiatric disorders. The application of new micro-fluidic devices along with miniaturized biosensors and transducers will enable the development of handheld point-of-care testing instruments which can analyse a drop of a blood within the time span of a single visit to the doctor's office. It is anticipated that these approaches will incorporate both biochemical and clinical information, resulting in unique profiles for each test subject. These profiles can in turn be used to drive personalized medicine approaches in this devastating disease area. In addition, smartphone applications (apps) for self-monitoring will see increasing use for improved patient outcomes.
authors.affiliation: Taunton and Somerset NHS Trust, Musgrove Park Hospital, Taunton, TA1 5DA, UK. francesca.guest@googlemail.com.
authors.forename: Francesca L
authors.initials: FL
authors.lastname: Guest
authors.affiliation: Laboratory of Neuroproteomics, Institute of Biology, University of Campinas, Cidade Universitária Zeferino Vaz, 13083-862, Campinas, Brazil.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D005544:Forecasting; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation; D006801:Humans; D056656:Lab-On-A-Chip Devices; D001523:Mental Disorders / Q000097:blood / Q000175:diagnosis*; D008904:Miniaturization; D063731:Mobile Applications; D000067716:Point-of-Care Testing / Q000639:trends; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D040901:Proteomics / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D011934:Reagent Strips; D000068997:Smartphone
chemical_list: D015415:Biomarkers; D011934:Reagent Strips
keywords: Biomarkers; Lab-on-a-chip; Personalized medicine; Point-of-care; Proteomics; Psychiatric disorders; Smartphone apps