title: Polyester fibers can be rendered calcium phosphate-binding by surface functionalization with bisphosphonate groups.
abstract: Fibers are often used as structural elements to improve the mechanical properties of materials such as brittle ceramic matrices by facilitating the dissipation of energy. However, this energy dissipation is mainly controlled by the interface between the two components, and a poorly designed fiber-matrix interface strongly reduces the efficacy of fiber reinforcement. Here, we present a versatile approach to control the affinity of biocompatible fibers to calcium-containing matrices to maximize the efficacy of reinforcement of calcium phosphates-based bioceramics by means of polymeric fibers. To this end, polyester fibers of tunable length were produced by electrospinning and aminolysis, followed by covalent attachment of alendronate, a bisphosphonate molecule with strong calcium-binding affinity, to the surface of the fibers. The proposed method allowed for selective control over the amount of alendronate conjugation, thereby improving the affinity of polyester fibers toward calcium phosphate bioceramics. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2335-2342, 2017.
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525EX Nijmegen, The Netherlands.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Polini
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525EX Nijmegen, The Netherlands.
authors.forename: Daniela Geta
authors.initials: DG
authors.lastname: Petre
authors.affiliation: Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, Faenza, 48018, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Iafisco
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525EX Nijmegen, The Netherlands.
authors.forename: Sonia
authors.initials: S
authors.lastname: de Lacerda Schickert
authors.affiliation: Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, Faenza, 48018, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Tampieri
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525EX Nijmegen, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: van den Beucken
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, 6525EX Nijmegen, The Netherlands.
authors.forename: Sander C G
authors.initials: SCG
authors.lastname: Leeuwenburgh
mesh_terms: D001665:Binding Sites; D001672:Biocompatible Materials / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry; D004164:Diphosphonates / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D004164:Diphosphonates; D011091:Polyesters; C033616:poly(lactide); C020243:calcium phosphate
keywords: bisphosphonate; calcium phosphate; electrospinning; poly-l-lactic acid; polyester