title: Mitochondrial regulation of cell death: a phylogenetically conserved control.
abstract: Mitochondria are fundamental for eukaryotic cells as they participate in critical catabolic and anabolic pathways. Moreover, mitochondria play a key role in the signal transduction cascades that precipitate many (but not all) regulated variants of cellular demise. In this short review, we discuss the differential implication of mitochondria in the major forms of regulated cell death.
authors.affiliation: Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.|INSERM, U1138, 75006 Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006 Paris.|Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Galluzzi
authors.affiliation: Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.|INSERM, U1138, 75006 Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006 Paris.|Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.affiliation: Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France.|INSERM, U1138, 75006 Paris, France.|Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France.|Université Pierre et Marie Curie/Paris VI, 75006 Paris.|Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, 94805 Villejuif, France.|Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, 17176 Stockholm, Sweden.|Pôle de Biologie, Hopitâl Européen George Pompidou, AP-HP; 75015 Paris, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
keywords: MTP-driven regulated necrosis; apoptosis; autophagy; autosis; ferroptosis; necroptosis; parthanatos; pyroptosis