title: Glistenings, anterior/posterior capsular opacification and incidence of Nd:YAG laser treatments with two aspheric hydrophobic acrylic intraocular lenses - a long-term intra-individual study.
abstract: OBJECTIVE
  To compare two hydrophobic acrylic intraocular lenses (IOLs) regarding long-term anterior/posterior capsular opacification (ACO/PCO) development and need for neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser treatment due to visually disturbing PCO, and to study development of glistenings in the IOL materials.
  
  
  METHODS
  In a prospective, randomized, intra-individual, comparative trial, 50 cataract patients received either an AcrySof IQ®SN60WF (Alcon, Fort Worth, TX, USA) or a Tecnis®ZCB00 (Abbott Medical Optics, Santa Ana, CA, USA) IOL in the first operated eye, and the second eye received the IOL type not implanted in the first eye. Anterior/posterior capsular opacification (ACO/PCO) and fibrosis were monitored with slit-lamp photography and semi-automated digital analysis 2 and 3 years postoperatively. Glistenings were semi-quantitatively assessed in slit-lamp photographs. Nd:YAG laser treatment for visually disturbing PCO was monitored.
  
  
  RESULTS
  Visual outcomes were similar for the two IOLs. Anterior capsular fibrosis and/or opacification developed more often in SN60WF eyes. Mean PCO area percentage was larger in ZCB00 eyes 3 years after surgery, but severity score did not differ with statistical significance between the two IOLs. Six ZCB00 eyes and 2 SN60WF eyes underwent Nd:YAG laser treatment during a mean of 4 years 8 months after surgery. This difference was not statistically significant. A high amount of glistenings developed in most SN60WF IOLs, while only few ZCB00 IOLs displayed a low degree of glistenings.
  
  
  CONCLUSIONS
  Visual outcomes, PCO development over time and need for Nd:YAG laser treatment were similar for the two IOLs. Anterior capsule fibrosis/contraction and glistenings were more pronounced with the SN60WF IOL.
authors.affiliation: Department of Ophthalmology, Linköping University, Linköping, Sweden.|Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Björn
authors.identifier: http://orcid.org/0000-0003-4666-3339
authors.initials: B
authors.lastname: Johansson
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D058442:Capsule Opacification / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D053685:Laser Therapy / Q000009:adverse effects*; D053844:Lasers, Solid-State / Q000009:adverse effects*; D007910:Lenses, Intraocular; D008297:Male; D057852:Posterior Capsule of the Lens / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D011474:Prosthesis Design; D013548:Sweden / Q000453:epidemiology; D014792:Visual Acuity
chemical_list: D000180:Acrylic Resins
keywords: glistenings; hydrophobic acrylic; intraocular lens; posterior capsular opacification