title: Trans-synaptic Retrograde Degeneration Following Hemispherectomy in Childhood.
abstract: Trans-synaptic retrograde degeneration (TRD) in the human visual system has been established. However there are few studies demonstrating macular thinning of the Retinal Ganglion cell Layer and/or Inner Plexiform layer (RGCL-IPL), corresponding to an acquired homonymous hemianopia. We report a 17 year old with a homonymous hemianopia, secondary to a hemispherectomy for intractable epilepsy. Three years following hemispherectomy, Optical Coherence Tomography (OCT) revealed evidence of TRD, corresponding to his complete homonymous hemianopia. Macular maps of the RGCL-IPL thickness provides useful additional information to measurements of optic nerve Retinal Nerve Fibre Layer Thickness (RNFL) in identifying TRD in acquired homonymous hemianopia.
authors.affiliation: Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children , London, United Kingdom.
authors.forename: Sian E
authors.identifier: 0000-0002-7612-3889
authors.initials: SE
authors.lastname: Handley
authors.affiliation: Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children , London, United Kingdom.
authors.forename: Vasiliki S
authors.initials: VS
authors.lastname: Panteli
authors.affiliation: Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children , London, United Kingdom.
authors.forename: Alki
authors.identifier: 0000-0003-3223-5202
authors.initials: A
authors.lastname: Liasis
keywords: Hemispherectomy; homonymous hemianopia; inner plexiform layer; optical coherence tomography; retinal ganglion cell layer; trans-synaptic retrograde degeneration