title: [Antipyretics in intensive care patients].
abstract: BACKGROUND
  Antipyretics are among the most widely prescribed drugs in German hospitals. Despite this widespread use, their role for treatment of critically ill patients still remains unclear. In particular, the questionable positive effects of reducing fever are discussed.
  
  
  OBJECTIVE
  In this review we aimed to summarize and discuss current study results covering the use of antipyretics in critically ill patients. Suspected effects with regard to fever reduction and lethality should be considered.
  
  
  METHODS
  A selective literature search was carried out in the PubMed database. We reviewed the bibliographies of all work considered relevant.
  
  
  RESULTS
  There are only a few studies on the use of antipyretics in intensive care patients, which are difficult to compare systematically due to different designs, protocols and endpoints. All in all, the decrease in temperature was very low (0.3 °C) and showed even adverse effects on 28-days mortality in sepsis. In patients with sepsis and ASS medication, a decreased mortality has been shown in retrospective analysis.
  
  
  CONCLUSIONS
  The benefit of fever control using antipyretics in intensive care patients with regard to endpoints like lethality remains unclear. Randomized controlled trials with suitable protocols and endpoints are needed to provide a solid base for development of guidelines.
authors.affiliation: Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, Hannover, Deutschland. psychosomatik.simon@googlemail.com.|, Hannover, Deutschland. psychosomatik.simon@googlemail.com.
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.affiliation: Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, Hannover, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Leffler
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use; D058633:Antipyretics / Q000627:therapeutic use*; D003422:Critical Care; D016638:Critical Illness / Q000401:mortality; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D018805:Sepsis / Q000150:complications
chemical_list: D058633:Antipyretics; D000082:Acetaminophen
keywords: Acetaminophen; Antipyretics; Critically ill; Fever; Lethality