title: Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers.
abstract: The cine magnetic resonance imaging based technique feature tracking-cardiac magnetic resonance (FT-CMR) is emerging as a novel, simple and robust method to evaluate myocardial strain. We investigated the distribution characteristics of left-ventricular myocardial strain using a novel cine MRI based deformation registration algorithm (DRA) in a cohort of healthy Chinese subjects. A total of 130 healthy Chinese subjects were enrolled. Three components of orthogonal strain (radial, circumferential, longitudinal) of the left ventricle were analyzed using DRA on steady-state free precession cine sequence images. A distinct transmural circumferential strain gradient was observed in the left ventricle that showed universal increment from the epicardial to endocardial myocardial wall (epiwall: -15.4 ± 1.9%; midwall: -18.8 ± 2.0%; endowall: -22.3 ± 2.3%, P < 0.001). Longitudinal strain showed a similar trend from epicardial to endocardial layers (epiwall: -16.0 ± 2.9%; midwall: -15.6 ± 2.7%; endowall: -14.8 ± 2.4%, P < 0.001), but radial strain had a very heterogeneous distribution and variation. In the longitudinal direction from the base to the apex of the left ventricle, there was a trend of decreasing peak systolic longitudinal strain (basal: -23.3 ± 4.6%; mid: -13.7 ± 7.3%; apical: -13.2 ± 5.5%; P < 0.001). In conclusion, there are distinct distribution patterns of circumferential and longitudinal strain within the left ventricle in healthy Chinese subjects. These distribution patterns of strain may provide unique profiles for further study in different types of myocardial disease.
authors.affiliation: Cardiology Division, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Cardiology Division, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: Cardiology Division, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wan
authors.affiliation: Cardiology Division, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Radiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Sun
authors.affiliation: Siemens Healthineers Northeast Asia Collaboration, Beijing, China.
authors.forename: Tian-Jing
authors.initials: TJ
authors.lastname: Zhang
authors.affiliation: Cardiology Division, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Wei-Hao
authors.initials: WH
authors.lastname: Li
authors.affiliation: Siemens Healthineers, Erlangen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Greiser
authors.affiliation: Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ, USA.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Jolly
authors.affiliation: Cardiology Division, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Cardiology Division, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002681:China; D005260:Female; D064368:Healthy Volunteers; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012984:Software; D055815:Young Adult