title: Microbiome and pancreatic cancer: A comprehensive topic review of literature.
abstract: OBJECTIVE
  To review microbiome alterations associated with pancreatic cancer, its potential utility in diagnostics, risk assessment, and influence on disease outcomes.
  
  
  METHODS
  A comprehensive literature review was conducted by all-inclusive topic review from PubMed, MEDLINE, and Web of Science. The last search was performed in October 2016.
  
  
  RESULTS
  Diverse microbiome alterations exist among several body sites including oral, gut, and pancreatic tissue, in patients with pancreatic cancer compared to healthy populations.
  
  
  CONCLUSIONS
  Pilot study successes in non-invasive screening strategies warrant further investigation for future translational application in early diagnostics and to learn modifiable risk factors relevant to disease prevention. Pre-clinical investigations exist in other tumor types that suggest microbiome manipulation provides opportunity to favorably transform cancer response to existing treatment protocols and improve survival.
authors.affiliation: Natalie Ertz-Archambault, Department of Internal Medicine, Mayo School of Graduate Medical Education, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States.
authors.forename: Natalie
authors.initials: N
authors.lastname: Ertz-Archambault
authors.affiliation: Natalie Ertz-Archambault, Department of Internal Medicine, Mayo School of Graduate Medical Education, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States.
authors.forename: Paul
authors.initials: P
authors.lastname: Keim
authors.affiliation: Natalie Ertz-Archambault, Department of Internal Medicine, Mayo School of Graduate Medical Education, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Von Hoff
mesh_terms: D063646:Carcinogenesis; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D064307:Microbiota; D010179:Pancreas / Q000382:microbiology* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000382:microbiology* / Q000473:pathology; D018570:Risk Assessment; D012307:Risk Factors
keywords: Biomarkers, cancer; Cancer screening tests; Human microbiome; Pancreatic Cancer; Treatment effectiveness