title: Palladium-Catalyzed Formal (5 + 2) Annulation between ortho-Alkenylanilides and Allenes.
abstract: 2-Alkenyltriflylanilides react with allenes upon treatment with catalytic amounts of Pd(OAc)2and Cu(II) to give highly valuable 2,3-dihydro-1H-benzo[b]azepines, in good yields, and with very high regio- and diastereoselectivities. Density functional theory (DFT) calculations suggest that the C-H activation of the alkenylanilide involves a classical concerted metalation-deprotonation (CMD) mechanism.
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors.forename: Borja
authors.initials: B
authors.lastname: Cendón
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Casanova
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.|Department of Inorganic Chemistry, University Politehnica of Bucharest , 1, Polizu street, RO-011061 Bucharest, România.
authors.forename: Cezar
authors.initials: C
authors.lastname: Comanescu
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.|CIQUP, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto , R. Campo Alegre s/n, P-4169-007, Porto, Portugal.
authors.forename: Rebeca
authors.initials: R
authors.lastname: García-Fandiño
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors.forename: Andrés
authors.initials: A
authors.lastname: Seoane
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors.forename: Moisés
authors.initials: M
authors.lastname: Gulías
authors.affiliation: Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela , 15782 Santiago de Compostela, Spain.
authors.forename: José L
authors.identifier: 0000-0002-7789-700X
authors.initials: JL
authors.lastname: Mascareñas