title: Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.
abstract: There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.
authors.affiliation: Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. s.janssen@amc.nl.|Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon. s.janssen@amc.nl.|Centre de Traitement Ambulatoire Lambaréné, Lambaréné, Gabon. s.janssen@amc.nl.|Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. s.janssen@amc.nl.|Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. s.janssen@amc.nl.|Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. s.janssen@amc.nl.
authors.forename: S
authors.initials: S
authors.lastname: Janssen
authors.affiliation: Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.|Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.|Centre de Traitement Ambulatoire Lambaréné, Lambaréné, Gabon.
authors.forename: K
authors.initials: K
authors.lastname: Osbak
authors.affiliation: Clinical Research Unit, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Holman
authors.affiliation: Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development, University of Amsterdam, Amsterdam, The Netherlands.|Faculty of Health Sciences, Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.|Department of Internal Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
authors.forename: S
authors.initials: S
authors.lastname: Hermans
authors.affiliation: Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.|Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.
authors.forename: A
authors.initials: A
authors.lastname: Moekotte
authors.affiliation: Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.|Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.
authors.forename: M
authors.initials: M
authors.lastname: Knap
authors.affiliation: Centre de Traitement Ambulatoire Lambaréné, Lambaréné, Gabon.
authors.forename: E
authors.initials: E
authors.lastname: Rossatanga
authors.affiliation: Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.|Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Massinga-Loembe
authors.affiliation: Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.|Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Alabi
authors.affiliation: Centre de Traitement Ambulatoire Lambaréné, Lambaréné, Gabon.|Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Adegnika
authors.affiliation: Department of Ophthalmology, VU Medical Center, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Meenken
authors.affiliation: Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: van Vugt
authors.affiliation: Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.|Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
authors.forename: P G
authors.initials: PG
authors.lastname: Kremsner
authors.affiliation: Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
authors.forename: G
authors.initials: G
authors.lastname: Meintjes
authors.affiliation: Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
authors.affiliation: Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.|Centre de Recherches Médicales en Lambaréné, Lambaréné, Gabon.|Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.|Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
authors.forename: M P
authors.initials: MP
authors.lastname: Grobusch
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000009:adverse effects*; D005260:Female; D005681:Gabon / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014376:Tuberculosis / Q000150:complications
chemical_list: D044966:Anti-Retroviral Agents
keywords: AIDS; HIV; Opportunistic infections; Tuberculosis