title: The Balloon-Based Manometry Evaluation of Swallowing in Patients with Amyotrophic Lateral Sclerosis.
abstract: The aim of the study was to analyse the disturbances of the oro-pharyngeal swallowing phase of dysphagia in amyotrophic lateral sclerosis (ALS) patients with the use of specific manometric measurements and to evaluate their plausible association with the duration of the disease. Seventeen patients with ALS were evaluated with manometric examinations of the oral and pharyngeal part of the gastrointestinal tract. Tests were carried out by using the oesophageal balloon-based method with four balloon transducers located 5 cm away from each other. The following manometric parameters were analysed: the base of tongue contraction (BTC) and the upper oesophageal sphincter pressure (UESP), and the hypopharyngeal suction pump (HSP) as well as the oro-pharyngeal, pharyngeal and hypopharyngeal transit time and average pharyngeal bolus velocity (oropharyngeal transit time (OTT), pharyngeal transit time (PTT), hypopharyngeal transit time (HTT) and average pharyngeal bolus velocity (APBV), respectively). Manomatric examinations during swallowing in patients with ALS showed significant weakness of BTC, a decrease of HSP and a decrease of the velocity of bolus transit inside the pharynx which were particularly marked between the first and the third examination. Manometric examinations of the oro-pharyngeal part of the gastrointestinal tract are useful and supportive methods in the analysis of swallowing disturbances in ALS patients.
authors.affiliation: Ear, Nose & Throat (ENT) Department, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland. j.tomik@uj.edu.pl.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Tomik
authors.affiliation: Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-503, Poland. b.tomik@op.pl.
authors.forename: Barbara
authors.initials: B
authors.lastname: Tomik
authors.affiliation: Ear, Nose & Throat (ENT) Department, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland. sebastian.gajec@gmail.com.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Gajec
authors.affiliation: Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland. piotr.ceranowicz@uj.edu.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ceranowicz
authors.affiliation: Department of Prosthetic Dentistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-155, Poland. malgorzata.pihut@uj.edu.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pihut
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland. mfolszan@cyf-kr.edu.pl.
authors.forename: Rafał
authors.initials: R
authors.lastname: Olszanecki
authors.affiliation: Ear, Nose & Throat (ENT) Department, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland. pawel.strek@uj.edu.pl.
authors.forename: Paweł
authors.initials: P
authors.lastname: Stręk
authors.affiliation: Ear, Nose & Throat (ENT) Department, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland. jacek.skladzien@uj.edu.pl.
authors.forename: Jacek
authors.initials: J
authors.lastname: Składzień
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000503:physiopathology*; D016022:Case-Control Studies; D003679:Deglutition / Q000502:physiology*; D004947:Esophagus / Q000502:physiology; D005260:Female; D041981:Gastrointestinal Tract / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D012720:Severity of Illness Index; D014059:Tongue / Q000502:physiology; D055815:Young Adult
keywords: amyotrophic lateral sclerosis; balloon-based manometry; bulbar onset; dysphagia