title: Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications.
abstract: BACKGROUND
  In this study, starch and polycaprolactone (PCL), composite nanofibers were fabricated by co-axial needle electrospinning technique. Processing parameters such as polymer concentration, flow rate and voltage had a marked influence on the composite fiber diameter. Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), mechanical and physical properties (such as density, viscosity and electrical conductivity) of the composite fibres were evaluated. Moreover, a cell culture test was performed in order to determine their cytotoxicity for wound dressing application.
  
  
  RESULTS
  The effect of starch ratio in the solution on the properties and morphological structure of the fibers produced was presented. With lower starch concentration values, the fibers have greater ultimate tensile strength characteristic (mostly 4 and 5 wt%). According to SEM results, it can be figured out that the nanofibers fabricated have good spinnability and morphology. The mean diameter of the fibers is about 150 nm. According to results of cell culture study, the finding can be determined that the increase of starch in the fiber also increases the cell viability.
  
  
  CONCLUSIONS
  Composite nanofibers of starch/PCL have been prepared using a co-axial needle electrospinning technique. PCL was successfully encapsulated within starch. Fiber formation was observed for different ratio of starch. With several test, analysis and measurement performed, some important parameters such as quality and effectuality of each fiber obtained for wound dressing applications were discussed in detail.
authors.affiliation: Kanuni Sultan Suleyman Training and Research Hospital, Turgut Ozal Street No.1, Halkalı, Kucukcekmece, 34303, Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Komur
authors.affiliation: Advanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey.|Department of Metallurgical and Materials Engineering, Institute of Pure and Applied Sciences, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Bayrak
authors.affiliation: Advanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey.|Department of Electrical and Electronics Engineering, Faculty of Technology, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Ekren
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey.
authors.forename: M S
authors.initials: MS
authors.lastname: Eroglu
authors.affiliation: Advanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey.|Department of Bioengineering, Faculty of Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey.
authors.forename: F N
authors.initials: FN
authors.lastname: Oktar
authors.affiliation: Aysin Biotechnology Limited Company, Istanbul, Turkey.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Sinirlioglu
authors.affiliation: Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yıldız Technical University, Davutpasa Campus, 34220, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yucel
authors.affiliation: Department of Orthopedics and Traumatology, Faculty of Medicine, Istanbul Medipol University, Halic Campus, 34083, Istanbul, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Guler
authors.affiliation: Advanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey. oguzhan@marmara.edu.tr.|Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Goztepe Campus, 34722, Istanbul, Turkey. oguzhan@marmara.edu.tr.
authors.forename: O
authors.initials: O
authors.lastname: Gunduz
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004553:Electric Conductivity; D004560:Electricity; D055595:Mechanical Phenomena; D051379:Mice; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology; D011091:Polyesters / Q000737:chemistry*; D013213:Starch / Q000737:chemistry*; D014783:Viscosity; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; D013213:Starch
keywords: Electrospinning; Nanofiber; PCL; Starch; Wound dressing