title: Exposure to Ambient Particulate Matter Induced COPD in a Rat Model and a Description of the Underlying Mechanism.
abstract: While the health effects of air pollution have been an international public health concern since at least the 1950s, recent research has focused on two broad sources of air pollution, namely, biomass fuel (BMF) and motor vehicle exhaust (MVE). Many studies have shown associations between air pollution PM and exacerbations of pre-existing COPD, but the role of air pollution PM in the development and progression of COPD is still uncertain. The current study indicates that rats can develop pronounced COPD following chronic exposure to air pollution PM (BMF and MVE), as characterized by lung function reduction, mucus metaplasia, lung and systemic inflammation, emphysema, and small airway remodeling. Comparative analyses demonstrate that both BMF and MVE activate similar pathogenesis that are linked to the development of COPD. These findings also show that some differences are found in the lungs of rats exposed to BMF or MVE, which might result in different phenotypes of COPD.
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.|The School of Basic Medicine, Guangzhou Medical University, Guangzhou, China.
authors.forename: Fang
authors.initials: F
authors.lastname: He
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Baoling
authors.initials: B
authors.lastname: Liao
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Jinding
authors.initials: J
authors.lastname: Pu
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Chenglong
authors.initials: C
authors.lastname: Li
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Mengning
authors.initials: M
authors.lastname: Zheng
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Lingmei
authors.initials: L
authors.lastname: Huang
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Dongxing
authors.initials: D
authors.lastname: Zhao
authors.affiliation: The Research Center of Experiment Medicine, Guangzhou Medical University, Guangzhou, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.affiliation: The State Key Lab of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Pixin
authors.initials: P
authors.lastname: Ran
mesh_terms: D000397:Air Pollution / Q000009:adverse effects; D056151:Airway Remodeling; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004781:Environmental Exposure; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D008168:Lung / Q000473:pathology / Q000503:physiopathology; D010316:Particle Size; D052638:Particulate Matter / Q000009:adverse effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology*; D017207:Rats, Sprague-Dawley; D012129:Respiratory Function Tests
chemical_list: D016207:Cytokines; D052638:Particulate Matter