title: Effects of femtosecond and excimer lasers on implanted KAMRA corneal inlay in animal models.
abstract: OBJECTIVE
  To evaluate the effect of femtosecond laser and excimer laser on an intracorneal inlay (KAMRA®) implanted in animal models.
  
  
  METHODS
  Femtosecond laser was used to create corneal intrastromal pockets at 250μm depth in five porcine eyes. Four intact KAMRA inlays, examined by slit-lamp biomicroscopy and light microscopy, were implanted in the pocket of four eyes. A standard LASIK flap was created above each implanted inlay in the four eyes using a femtosecond laser with flap thicknesses of 150μm, 130μm, 110μm and 90μm. In the fifth porcine eye, a LASIK flap was created using femtosecond laser at 110μm depth, and a fifth inlay was then implanted in the 250μm pocket. Excimer laser ablation was performed under the flap targeting a -3.00 refraction. The inlay was then explanted, examined and reimplanted in the same pocket followed by a second similar excimer laser ablation.
  
  
  RESULTS
  Significant burn, shrinkage and distortion of microholes were noted in all the first four inlays following the femtosecond laser flap creation at all the various flap thicknesses. The damage was noted to be more prominent as the distance between the flap and inlay decreased. No apparent effect was noted on the fifth inlay following repeated excimer laser ablations.
  
  
  CONCLUSIONS
  Unlike excimer laser, femtosecond laser appears to be hazardous and damaging to the intracorneal KAMRA inlay when applied above it.
authors.affiliation: Department of Ophthalmology, Saint-George Hospital, University Medical Center, Beirut, Lebanon.
authors.forename: F K
authors.initials: FK
authors.lastname: Sammouh
authors.affiliation: Department of Ophthalmology, Saint-George Hospital, University Medical Center, Beirut, Lebanon.
authors.forename: T A
authors.initials: TA
authors.lastname: Baban
authors.affiliation: Department of Ophthalmology, Saint-George Hospital, University Medical Center, Beirut, Lebanon.
authors.forename: W N
authors.initials: WN
authors.lastname: Dandan
authors.affiliation: Department of Ophthalmology, Saint-George Hospital, University Medical Center, Beirut, Lebanon. Electronic address: advancedeyecare.ew@gmail.com.
authors.forename: E L
authors.initials: EL
authors.lastname: Warrak
mesh_terms: D000818:Animals; D003319:Corneal Stroma / Q000601:surgery*; D005137:Eye, Artificial / Q000009:adverse effects; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D054018:Lasers, Excimer / Q000009:adverse effects / Q000627:therapeutic use*; D023421:Models, Animal; D011305:Presbyopia / Q000601:surgery; D019736:Prostheses and Implants / Q000009:adverse effects; D019919:Prosthesis Implantation / Q000009:adverse effects; D013552:Swine; D014792:Visual Acuity
keywords: Excimer laser; Femtosecond laser; Implant KAMRA; KAMRA inlay; Laser excimer; Laser femtoseconde; Presbyopia; Presbytie