title: Testicular Tissue Cryopreservation and Ethical Considerations: A Scoping Review.
abstract: Testicular tissue cryopreservation (TTCP) aims to preserve the future option of genetic reproduction for prepubescent cancer patients who are at risk of infertility as a result of their cancer therapies. This technology is experimental and currently only offered in the research context. As TTCP moves towards becoming more widely available, it is imperative that healthcare providers recognize the complex ethical issues surrounding this technology. This scoping review study identifies and assesses the range and depth of ethical concerns related to this testicular tissue cryopreservation technology. At present, no such scoping review of ethical concerns exists in the TTCP literature. The forty-three full-text articles included in this study yielded twenty-two different ethical considerations discussed in relation to TTCP. It was observed that these ethical considerations fit within a mainstream Principlism approach to bioethics. Accordingly, there are ethical gaps in the TTCP literature that can be identified with alternative moral lenses. In particular, it was found that ethical concerns related to context and relational aspects of identity were absent in nearly all ethical examinations of TTCP. Furthermore, only 9 per cent of articles reviewed in this study focused primarily on the ethics of TTCP, thus demonstrating a need for further in depth ethical analyses of this technology. The results of this study are important for supporting the ethical provision of TTCP and can contribute to policy and guideline development. The findings of this study demonstrate the need for greater depth and diversity in analyses of ethical considerations related to this technology.
authors.affiliation: Novel Tech Ethics, Faculty of Medicine, Dalhousie University, 1379 Seymour Street, PO BOX 15000, Halifax, NS, B3H 4R2, Canada. Angel.p@dal.ca.
authors.forename: Angel
authors.initials: A
authors.lastname: Petropanagos
mesh_terms: D015925:Cryopreservation; D026689:Ethical Analysis; D006801:Humans; D007248:Infertility, Male / Q000209:etiology; D008297:Male; D009369:Neoplasms / Q000628:therapy; D011627:Puberty; D012098:Reproduction / Q000941:ethics*; D027724:Reproductive Techniques, Assisted / Q000941:ethics*; D013737:Testis
keywords: Clinical trials; Ethical considerations; Fertility Preservation; Pediatric cancer patients; Scoping Review; Testicular tissue cryopreservation