title: De Novo and Recurrence of Nonalcoholic Steatohepatitis After Liver Transplantation.
abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developing countries. Approximately 25% of patients with NAFLD develop nonalcoholic steatohepatitis (NASH). NASH-related cirrhosis is now a leading listing indication for liver transplantation in the United States. Although posttransplant survival for NASH-related cirrhosis is comparable with that of other liver diseases, many patients have features of metabolic syndrome, which can contribute to a recurrence of NAFLD or NASH. This article reviews the epidemiology, pathophysiology, and treatment of de novo and recurrence of NASH after liver transplantation.
authors.affiliation: Division of Gastroenterology, Duke University Medical Center, 40 Duke Medicine Circle, PO Box 3913, Durham, NC 27710, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Kappus
authors.affiliation: Division of Gastroenterology, Duke University Medical Center, 40 Duke Medicine Circle, PO Box 3913, Durham, NC 27710, USA. Electronic address: manal.abdelmalek@duke.edu.
authors.forename: Manal
authors.initials: M
authors.lastname: Abdelmalek
mesh_terms: D014943:Global Health; D006801:Humans; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects*; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology* / Q000209:etiology; D011183:Postoperative Complications; D012008:Recurrence; D012307:Risk Factors
keywords: Cryptogenic cirrhosis; Hyperlipidemia; Hypertension; Insulin resistance; Metabolic syndrome; Nonalcoholic fatty liver disease; Obesity