title: Epileptic Discharge Related Functional Connectivity Within and Between Networks in Benign Epilepsy with Centrotemporal Spikes.
abstract: Benign epilepsy with centrotemporal spikes (BECTS) is a common childhood epilepsy syndrome associated with abnormalities in neurocognitive domains, particularly during interictal epileptiform discharges (IEDs). Here, we investigated the effects of IEDs on brain's intrinsic connectivity networks in 43 BECTS patients and 28 matched healthy controls (HCs). Patients were further divided into IED and non-IED subgroups based on simultaneous EEG-fMRI recordings. Functional connectivity within and between five networks, corresponding to seizure origination and cognitive processes, were analyzed to measure IED effects. We found that patients exhibited increased connectivity within the auditory network (AN) and the somato-motor network (SMN), and decreased connectivity within the basal ganglia network and the dorsal attention network, suggesting that both transient and chronic seizure activity may disturb normal network organization. The IED group showed decreased functional connectivity within the default mode network (DMN) compared with the non-IED group and HCs, implying that the DMN was selectively impaired during epileptiform discharges associated with altered self-referential cognitive functions. Moreover, the IED group exhibited increased positive correlations between the AN and the SMN, which suggests a possible excessive influence of centrotemporal spiking on information processing in the auditory system. The association between epileptic activity and network dysfunctions highlights their importance in investigating the pathological mechanism underlying BECTS.
authors.affiliation: * Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: † Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, Anhui Medical University, Hefei 230000, P. R. China.
authors.forename: Gong-Jun
authors.initials: GJ
authors.lastname: Ji
authors.affiliation: * Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: ‡ Department of Psychiatry, the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang 310009, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: § Department of Neurology, the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang 310009, P. R. China.
authors.forename: Mei-Ping
authors.initials: MP
authors.lastname: Ding
authors.affiliation: § Department of Neurology, the Second Affiliated Hospital of Medial College, Zhejiang University, Zhejiang 310009, P. R. China.
authors.forename: Ye-Lei
authors.initials: YL
authors.lastname: Tang
authors.affiliation: * Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China.
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
authors.affiliation: * Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liao
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D016022:Case-Control Studies; D002648:Child; D003198:Computer Simulation; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008959:Models, Neurological; D009434:Neural Pathways / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D018709:Statistics, Nonparametric
chemical_list: D000927:Anticonvulsants; D010100:Oxygen
keywords: Benign epilepsy with centrotemporal spikes; EEG-fMRI; independent component analysis; interictal epileptiform discharges; intrinsic connectivity networks