title: Dynamic conformal arc radiosurgery for arteriovenous malformations: Outcome and influence of clinical and dosimetrical data.
abstract: To assess efficacy, toxicity, and their predictive factors for dynamic conformal arc arteriovenous malformations (AVM) stereotactic radiosurgery.
  
  
  
  Data concerning 90 consecutive patients were retrospectively studied. Clinical, radiological, dosimetrical data and quality indexes were computed.
  
  
  
  AVM median volume was 1.06cc. Median prescribed dose was 22Gy. Total occlusion was obtained for 69% of patients. Post-radiosurgery annual hemorrhage rate was 2.2%. Predictive factor for total occlusion was delivered dose. Undesirable events occurred for 28% of patients. Predictive factors for adverse events were AVM revealing mode with seizure or headache, age≤28, AVM diameter≥3cm Spetzler-Martin score≥4, V12Gy≥2cc, large target volume and low homogeneity index (p<0.05). Brain parenchymal radiological reactions concerned 23% of patients, and their predictive factors were AVM revelation by seizure, deep localization, AVM diameter≥3cm, Spetzler-Martin score≥4, previous radiosurgery, numerous embolization, target volume, V12Gy and low homogeneity index (p<0.05).
  
  
  
  Occlusion rate and toxicities are comparable to other series. Specific attention must be paid on pre-treatment clinical data, and target volume should be as small as possible, without reducing the delivered dose.
authors.affiliation: Radiation Oncology, Integrated Center of Oncology, Saint-Herblain, France. Electronic address: kclementcolmou@gmail.com.
authors.forename: Karen
authors.initials: K
authors.lastname: Clement-Colmou
authors.affiliation: Neurosurgery, Centre Hospitalier Universitaire, Nantes, France. Electronic address: Vincent.roualdes@chu-nantes.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Roualdes
authors.affiliation: Neurosurgery, Centre Hospitalier Universitaire, Nantes, France. Electronic address: Stephaneandre.Martin@chu-nantes.fr.
authors.forename: Stéphane-André
authors.initials: SA
authors.lastname: Martin
authors.affiliation: Medical Physics, Integrated Center of Oncology, Saint-Herblain, France. Electronic address: Stephanie.Josset@ico.unicancer.fr.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Josset
authors.affiliation: Neuroradiology, Centre Hospitalier Universitaire, Nantes, France. Electronic address: Hubert.Desal@chu-nantes.fr.
authors.forename: Hubert
authors.initials: H
authors.lastname: Desal
authors.affiliation: Statistics, Integrated Center of Oncology, Saint-Herblain, France. Electronic address: Loic.Campion@ico.unicancer.fr.
authors.forename: Loïc
authors.initials: L
authors.lastname: Campion
authors.affiliation: Radiation Oncology, Integrated Center of Oncology, Saint-Herblain, France. Electronic address: Francois.Thillays@ico.unicancer.fr.
authors.forename: François
authors.initials: F
authors.lastname: Thillays
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
keywords: Arteriovenous malformation; Dynamic conformal arc radiotherapy; Linac; Novalis; Radiosurgery; Stereotactic radiotherapy