title: From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Indocyanine Green Loaded Gold Nanorod@liposome Core-Shell Nanoparticles in Liver Cancer.
abstract: Conventional imaging methods encounter challenges in diagnosing liver cancer that is less than 10 mm or without typical hypervascular features. With deep penetration and high spatial resolution imaging capability, the emerging photoacoustic tomography may offer better diagnostic efficacy for noninvasive liver cancer detection. Moreover, near-infrared fluorescence imaging-guided hepatectomy was proven to be able to identify nodules at the millimeter level. Thus, suitable photoacoustic and fluorescence dual-modality imaging probe may benefit patients in early diagnosis and complete resection. In this study, we fabricated indocyanine green loaded gold nanorod@liposome core-shell nanoparticles (Au@liposome-ICG) to integrate both imaging strategies. These nanoparticles exhibit superior biocompatibility, high stability, and enhanced dual-model imaging signals. Next, we explored their effectiveness of tumor detection and surgery guidance in orthotopic liver cancer mouse models. Histological analysis confirmed the accuracy of the probe in liver cancer detection and resection. This novel dual-modality nanoprobe holds promise for early diagnosis and better surgical outcome of liver cancer and has great potential for clinical translation.
authors.affiliation: Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University , Guangzhou 510280, China.|CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Beijing 100190, China.|Guangdong Provincial Clinical and Engineering Center of Digital Medicine , Guangzhou 510280, China.
authors.forename: Tianpei
authors.initials: T
authors.lastname: Guan
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Beijing 100190, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Shang
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Beijing 100190, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Beijing 100190, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University , Guangzhou 510280, China.
authors.forename: Chihua
authors.initials: C
authors.lastname: Fang
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Beijing 100190, China.
authors.forename: Jie
authors.identifier: 0000-0003-2025-1870
authors.initials: J
authors.lastname: Tian
authors.affiliation: CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences , Beijing 100190, China.|Beijing Key Laboratory of Molecular Imaging , Beijing 100190, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D006046:Gold; D006801:Humans; D007208:Indocyanine Green; D008081:Liposomes / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D008297:Male; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D043942:Nanotubes / Q000737:chemistry*; D061088:Photoacoustic Techniques / Q000379:methods*; D013514:Surgical Procedures, Operative; D014054:Tomography / Q000379:methods*
chemical_list: D008081:Liposomes; D006046:Gold; D007208:Indocyanine Green