title: Vitamin D Signaling Pathways Confer the Susceptibility of Esophageal Squamous Cell Carcinoma in a Northern Chinese Population.
abstract: Experimental studies have determined the chemopreventive effects of vitamin D against the esophageal squamous cell carcinoma (ESCC); however, results from the epidemiological studies are not yet well established. The current study aimed to evaluate the associations between plasma vitamin D levels and variants on vitamin D metabolic-related genes with the risks for ESCC. A hospital-based case-control study was performed. Five hundred eighty-two ESCC patients and 569 controls were recruited in a Northern Chinese population. Common variants on vitamin D metabolism-related genes CYP24A1, DHCR7, GC, CYP27B1, and vitamin D receptor (VDR) and the plasma 25(OH)D level were determined. The unconditional logistic regression method was applied to determine the associations between the variants and vitamin D level and ESCC. Higher plasma 25(OH)D was associated with a reduced risk for ESCC, especially for rs2296241, rs11568820, and rs4646536. The variants rs2296241 on CYP24A1 and rs11568820 on VDR are significantly associated with ESCC cancer. Vitamin D signaling pathways may participate in the ESCC development. Further studies with larger sample size are warranted to confirm the results. Intervention studies are needed to determine whether vitamin D supplementation may reduce the ESCC risk in the Chinese population.
authors.affiliation: a School of Public Health, Central South University , Changsha , Hunan , China.|b Department of Preventive Medicine , Changzhi Medical College , Changzhi , China.
authors.forename: Jianzhou
authors.initials: J
authors.lastname: Yang
authors.affiliation: c Central Laboratory , Heping Hospital Affiliated to Changzhi Medical College , Changzhi , China.
authors.forename: Haili
authors.initials: H
authors.lastname: Wang
authors.affiliation: c Central Laboratory , Heping Hospital Affiliated to Changzhi Medical College , Changzhi , China.
authors.forename: Aifang
authors.initials: A
authors.lastname: Ji
authors.affiliation: c Central Laboratory , Heping Hospital Affiliated to Changzhi Medical College , Changzhi , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ma
authors.affiliation: c Central Laboratory , Heping Hospital Affiliated to Changzhi Medical College , Changzhi , China.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Wang
authors.affiliation: d Department of Oncology , Heping Hospital Affiliated to Changzhi Medical College , Changzhi , China.
authors.forename: Changhong
authors.initials: C
authors.lastname: Lian
authors.affiliation: d Department of Oncology , Heping Hospital Affiliated to Changzhi Medical College , Changzhi , China.
authors.forename: Zibai
authors.initials: Z
authors.lastname: Wei
authors.affiliation: e Henan Key Laboratory for Esophageal Cancer Research, Zhengzhou University , Zhengzhou , China.
authors.forename: Lidong
authors.initials: L
authors.lastname: Wang
mesh_terms: D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000235:genetics; D000368:Aged; D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D065668:Vitamin D3 24-Hydroxylase / Q000235:genetics
chemical_list: C063898:DBP protein, human; D004268:DNA-Binding Proteins; D018167:Receptors, Calcitriol; D014157:Transcription Factors; C579457:VDR protein, human; D014807:Vitamin D; C104450:25-hydroxyvitamin D; C585549:CYP24A1 protein, human; D065668:Vitamin D3 24-Hydroxylase; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase; C000600378:CYP27B1 protein, human; D044925:Oxidoreductases Acting on CH-CH Group Donors; C019995:7-dehydrocholesterol reductase