title: Soulieoside O, a new cyclolanostane triterpenoid glycoside from Souliea vaginata.
abstract: A new cyclolanostane triterpenoid glycoside, soulieoside O (1), together with 25-O-acetylcimigenol-3-O-β-d-xylopyranoside (2) and cimigenol-3-O-β-d-xylopyranoside (3), was isolated from the rhizomes of Souliea vaginata. Their structures were characterized by spectroscopic analysis and chemical methods. The new compound showed moderate inhibitory activity against three human cancer cell lines with IC50values of 9.3-22.5 μM.
authors.affiliation: a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.affiliation: a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Li
authors.affiliation: b School of Pharmacy, Wenzhou Medical University , Wenzhou 325035 , China.
authors.forename: Yin-Di
authors.initials: YD
authors.lastname: Zhu
authors.affiliation: c School of Pharmaceutical Science, Hainan Medical University , Haikou 571199 , China.
authors.forename: Xiao-Po
authors.initials: XP
authors.lastname: Zhang
authors.affiliation: a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , China.
authors.forename: Guo-Xu
authors.initials: GX
authors.lastname: Ma
authors.affiliation: a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , China.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
authors.affiliation: d Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Huaihua 418008 , China.
authors.forename: Yi-Lin
authors.initials: YL
authors.lastname: Liu
authors.affiliation: d Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Huaihua 418008 , China.
authors.forename: Zheng-Hong
authors.initials: ZH
authors.lastname: Luo
authors.affiliation: d Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Huaihua 418008 , China.
authors.forename: Di-Zhao
authors.initials: DZ
authors.lastname: Chen
authors.affiliation: d Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Huaihua 418008 , China.
authors.forename: Qiong-Yu
authors.initials: QY
authors.lastname: Zou
authors.affiliation: d Key Laboratory of Hunan Province for Study and Utilization of Ethnic Medicinal Plant Resources, Department of Chemistry & Chemical Engineering , Huaihua University , Huaihua 418008 , China.
authors.forename: Zi-Jian
authors.initials: ZJ
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029626:Ranunculaceae / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C506863:25-O-acetylcimigenol-3-O-beta-D-xylopyranoside; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D014315:Triterpenes; C000625134:soulieoside O; C435816:cimigenol 3-O-xylopyranoside
keywords: Souliea vaginata; cyclolanostane triterpenoid; cytotoxicity; soulieoside O