title: Correlation between Postoperative Area of High Autofluorescence in Macula and Visual Acuity after Macular Hole Closure.
abstract: OBJECTIVE
  To determine the correlation between the preoperative basal diameter of macular hole, the postoperative area of high autofluorescence (AF) in macula, and visual acuity in full-thickness macular hole.
  
  
  METHODS
  Forty-nine patients with full-thickness macular hole who underwent vitrectomy and C3F8filling were reviewed. The preoperative diameter of macular hole, the 6 months postoperative area of high AF in macula if it existed, the length of inner segment/outer segment (IS/OS) defect, and visual acuity were obtained. The correlation between them was determined.
  
  
  RESULTS
  At postoperative 6 months, the rate of high AF in macula was 63.3%. There were statistical differences between with and without high AF groups in postoperative best-corrected visual acuity (BCVA) (t = -2.751, p = 0.008), preoperative basal diameter of macular hole (t = -4.946, p = 0.00001), and postoperative length of IS/OS defect (t = -8.351, p<0.00001). Simple linear regression analysis showed high positive correlations between preoperative basal diameter of macular hole and area of high AF (p<0.00001, r = 0.893), postoperative length of IS/OS defect and area of high fundus AF (FAF) (p<0.00001, r = 0.779), and negative correlations between area of high AF and postoperative BCVA (p = 0.037, r = 0.375). There was low correlation between diameter of macular hole and postoperative BCVA (p = 0.112).
  
  
  CONCLUSIONS
  The preoperative basal diameter of macular hole and postoperative length of IS/OS defect decides the postoperative area of high AF in macula to some degree, and the postoperative area of high AF in macula can be an evaluating indicator for poor macular function recovery.
authors.affiliation: Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province - China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province - China.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Shang
authors.affiliation: Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province - China.
authors.forename: Jingxue
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province - China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province - China.
authors.forename: Cunxi
authors.initials: C
authors.lastname: Ye
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011237:Predictive Value of Tests; D020127:Recovery of Function / Q000502:physiology; D012044:Regression Analysis; D012167:Retinal Perforations / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*; D014821:Vitrectomy / Q000379:methods*
keywords: Autofluorescence; Macular hole; Visual acuity