title: Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index.
abstract: BACKGROUND
  Bipolar disorder is one of the most debilitating psychiatric disorders characterized by disruptive episodes of mania/hypomania and depression. Considering the complex role of biological and environmental factors in the etiology of affective disorders, recent studies have focused on oxidative stress, which may damage nerve cell components and take part in pathophysiology. The aim of the present study was to contribute to the data about oxidative stress in bipolar disorder by detecting the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels of manic episode (ME) and euthymic (EU) patients and by comparing these results with those of healthy controls (HCs).
  
  
  METHODS
  The study population consisted of 28 EU outpatients meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for bipolar disorder I and 23 inpatients who were currently hospitalized in a psychiatry ward with the diagnosis of the bipolar disorder ME according to the DSM-5 criteria. Forty-three healthy subjects were included in the study as the control group (HC). Serum TAS, TOS, and OSI levels of all the participants were determined.
  
  
  RESULTS
  Statistical analysis of serum TAS, TOS, and OSI levels did not show any significant differences between the ME patients, EU patients, and HCs. Comparison between the bipolar disorder patients (ME+EU) and HC also did not reveal any statistically significant difference between these two groups in terms of serum TAS, TOS, and OSI levels.
  
  
  CONCLUSIONS
  To date, studies on oxidative stress in bipolar disorder have led to controversial results. In the present study, no statistically significant difference was detected between the oxidative parameters of bipolar disorder patients and HCs. In order to comprehensively evaluate oxidative stress in bipolar disorder, further studies are needed.
authors.affiliation: Clinic of Psychiatry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Cingi Yirün
authors.affiliation: Clinic of Biochemistry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Kübranur
authors.initials: K
authors.lastname: Ünal
authors.affiliation: Clinic of Psychiatry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Altunsoy Şen
authors.affiliation: Clinic of Psychiatry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Yirün
authors.affiliation: Clinic of Psychiatry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Aydemir
authors.affiliation: Clinic of Psychiatry, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Göka
keywords: Bipolar disorder; oxidative stress; total antioxidant status; total oxidant status