title: Green microparticles based on a chitosan/lactobionic acid/linoleic acid association. Characterisation and evaluation as a new carrier system for cosmetics.
abstract: The association chitosan/linoleic acid/lactobionic acid in aqueous solution spontaneously led to the formation of stable microparticles with a liquid hydrophobic core consisting of linoleic acid surrounded by a shell of chitosan/lactobionic acid. The originality of the microparticles arises from the fact that they are formed by the association of three ingredients of cosmetic interest, including a skin penetration enhancer (linoleic acid). Dynamic light scattering (DLS) measurements showed microparticles with a mean diameter of 1-2 μm. The presence of a hydrophobic liquid core was observed by transmission electron microscopy (TEM). The ability of these microparticles to encapsulate phenylethyl resorcinol, a hydrophobic skin lightener, was evaluated and its encapsulation was confirmed thanks to T2measurements and nuclear Overhauser effects (nOe) signs.
authors.affiliation: a Laboratoire des IMRCP, Université Paul Sabatier , Toulouse , France.
authors.forename: C
authors.initials: C
authors.lastname: Chaouat
authors.affiliation: b Laboratoire SPCMIB, Université Paul Sabatier , Toulouse , France.
authors.forename: S
authors.initials: S
authors.lastname: Balayssac
authors.affiliation: b Laboratoire SPCMIB, Université Paul Sabatier , Toulouse , France.
authors.forename: M
authors.initials: M
authors.lastname: Malet-Martino
authors.affiliation: c Laboratoire Pierre Fabre Dermo-Cosmétique , Toulouse , France.
authors.forename: F
authors.initials: F
authors.lastname: Belaubre
authors.affiliation: c Laboratoire Pierre Fabre Dermo-Cosmétique , Toulouse , France.
authors.forename: E
authors.initials: E
authors.lastname: Questel
authors.affiliation: c Laboratoire Pierre Fabre Dermo-Cosmétique , Toulouse , France.
authors.forename: A M
authors.initials: AM
authors.lastname: Schmitt
authors.affiliation: c Laboratoire Pierre Fabre Dermo-Cosmétique , Toulouse , France.
authors.forename: S
authors.initials: S
authors.lastname: Poigny
authors.affiliation: a Laboratoire des IMRCP, Université Paul Sabatier , Toulouse , France.
authors.forename: S
authors.initials: S
authors.lastname: Franceschi
authors.affiliation: a Laboratoire des IMRCP, Université Paul Sabatier , Toulouse , France.
authors.forename: E
authors.initials: E
authors.lastname: Perez
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D003358:Cosmetics / Q000737:chemistry*; D004187:Disaccharides / Q000737:chemistry*; D019787:Linoleic Acid / Q000737:chemistry*; D010316:Particle Size
chemical_list: D003358:Cosmetics; D004187:Disaccharides; C005608:lactobionic acid; D048271:Chitosan; D019787:Linoleic Acid
keywords: Chitosan; lactobionic acid/linoleic acid; phenylethyl resorcinol encapsulation; self-assembled microparticles