title: Differences in Clinicopathological Characteristics and Prognosis Between Primary and Postirradiation Tongue Squamous Cell Carcinoma.
abstract: OBJECTIVE
  Many cases of postirradiation oral carcinoma have been reported, but its prognosis and optimal treatment modalities are not clear. Thus, the clinicopathologic characteristics and prognosis between postirradiation tongue squamous cell carcinoma (PTSCC) and primary tongue squamous cell carcinoma (TSCC) were compared.
  
  
  METHODS
  A retrospective cohort study was conducted to assess patients with PTSCC or TSCC. The primary predictor variable was tumor type. The primary outcome variable was prognosis, and the additional outcome variables were clinicopathologic characteristics. Survival analysis was performed, and Kaplan-Meier analysis was conducted to compare the effects of clinicopathologic factors on survival using SPSS 18.0. Moreover, the Cox model was applied in multivariate analysis.
  
  
  RESULTS
  The sample was composed of 449 patients with PTSCC (n = 68; 47 men and 21 women; age range, 31 to 72 yr) and TSCC (n = 381; 247 men and 134 women; age range, 20 to 86 yr). Patients with PTSCC were found to have a substantially poorer prognosis and several specific clinicopathologic characteristics compared with patients with TSCC.
  
  
  CONCLUSIONS
  Patients with PTSCC had several unique biological tumor characteristics and a poorer prognosis than patients with TSCC. Thus, different surgical strategies should be used to treat patients with PTSCC.
authors.affiliation: Professor, Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Chuanzheng
authors.initials: C
authors.lastname: Sun
authors.affiliation: Associate Professor, Department of Radiotherapy, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Resident, Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Resident, Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Resident, Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Juanzhang
authors.initials: J
authors.lastname: Luo
authors.affiliation: Resident, Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Chen
authors.affiliation: Resident, Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming, China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Chu
authors.affiliation: Professor, Radiology Department, Shanghai Ninth People's Hospital Affiliated Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Tao
authors.affiliation: Professor and Chairman, Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address: ankuiyang2016@126.com.
authors.forename: Ankui
authors.initials: A
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D055815:Young Adult