title: Longitudinal Assessment of Dentate Nuclei Relaxometry during Massive Gadobutrol Exposure.
abstract: We report the assessment of Dentate Nuclei (DN) R1 (1/T1) and R2* (1/T2*) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric MR measurements within 2 years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes.
authors.affiliation: Department of Advanced Biomedical Sciences, Neuroradiology Unit, University "Federico II".
authors.forename: Enrico
authors.initials: E
authors.lastname: Tedeschi
authors.affiliation: Department of Advanced Biomedical Sciences, Neuroradiology Unit, University "Federico II".
authors.forename: Sirio
authors.initials: S
authors.lastname: Cocozza
authors.affiliation: IRCCS SDN.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Borrelli
authors.affiliation: Department of Advanced Biomedical Sciences, Neuroradiology Unit, University "Federico II".
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Ugga
authors.affiliation: Department of Neurosciences, Reproductive and Odonto-stomatological Sciences, University "Federico II".
authors.forename: Vincenzo Brescia
authors.initials: VB
authors.lastname: Morra
authors.affiliation: Institute of Biostructure and Bioimaging, National Research Council.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Palma
mesh_terms: D000328:Adult; D002526:Cerebellar Diseases / Q000000981:diagnostic imaging*; D002529:Cerebellar Nuclei / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000000981:diagnostic imaging*; D009942:Organometallic Compounds; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds
keywords: dentate nucleus; gadolinium; magnetic resonance imaging contrast media; multiple sclerosis; relaxometry