title: Effects of α-Galactooligosaccharides from Chickpeas on High-Fat-Diet-Induced Metabolic Syndrome in Mice.
abstract: The gut microbiota has the ability to modulate host energy homeostasis, which may regulate metabolic disorders. Functional oligosaccharide may positively regulate the intestinal microbiota. Therefore, effects of α-galactooligosaccharides (α-GOS) from chickpea on high-fat-diet (HFD)-induced metabolic syndrome and gut bacterial dysbiosis were investigated. After 6 weeks of intervention, HFD led to significant increases in levels of blood glucose, total cholesterol, triglyceride, glycated serum protein, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol of mice compared to normal-chow-fed mice. Meanwhile, all of the α-GOS-treated groups significantly decreased above parameters compared to the HFD group. HFD could significantly decrease the content of all bacteria, especially Bacteroides (9.82 ± 0.09 versus 10.3 ± 0.10; p < 0.05) and Lactobacillus (6.67 ± 0.18 versus 7.30 ± 0.24; p < 0.05), and a decrease in the production of short-chain fatty acids was also observed. Treatment with α-GOS significantly increased the number of Bifidobacterium (6.07 ± 0.23 of the low-dose treatment versus 5.65 ± 0.20 of the HFD group) and Lactobacillus (7.22 ± 0.16 of the low-dose treatment). It also significantly promoted the secretion of propionic and butyric acids. These results indicate that α-GOS from chickpeas may affect the metabolic disorders and gut bacterial ecosystem in a positive way.
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210095, People's Republic of China.
authors.forename: Zhuqing
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Nutrition and Food Branch of China Association of Gerontology and Geriatrics , Beijing 100050, People's Republic of China.
authors.forename: Wanyong
authors.initials: W
authors.lastname: Lyu
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210095, People's Republic of China.
authors.forename: Minhao
authors.initials: M
authors.lastname: Xie
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210095, People's Republic of China.
authors.forename: Qingxia
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210095, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ye
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210095, People's Republic of China.
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210095, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210095, People's Republic of China.
authors.forename: Xiaoxiong
authors.identifier: http://orcid.org/0000-0003-2954-3896
authors.initials: X
authors.lastname: Zeng
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism; D002087:Butyrates / Q000378:metabolism; D029863:Cicer / Q000378:metabolism*; D059305:Diet, High-Fat / Q000009:adverse effects; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D008075:Lipoproteins, HDL / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy* / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009844:Oligosaccharides / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D011422:Propionates / Q000378:metabolism
chemical_list: D002087:Butyrates; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D009844:Oligosaccharides; D010936:Plant Extracts; D011422:Propionates; C029658:propionic acid
keywords: chickpea; gut microbiota; metabolic syndrome; short-chain fatty acid; α-galactooligosaccharide