title: Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction.
abstract: Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.
authors.affiliation: Graduate Institute of Biotechnology, Chinese Culture University, YangMingShan, Taipei 11114, Taiwan, R.O.C.
authors.forename: Tran Duong
authors.initials: TD
authors.lastname: Thuy
authors.affiliation: Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 70000, Vietnam.
authors.forename: Nam Nhut
authors.initials: NN
authors.lastname: Phan
authors.affiliation: Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26506, USA.
authors.forename: Han-Gang
authors.initials: HG
authors.lastname: Yu
authors.affiliation: Graduate Institute of Biotechnology, Chinese Culture University, YangMingShan, Taipei 11114, Taiwan, R.O.C.
authors.forename: Shu-Yin
authors.initials: SY
authors.lastname: Wang
authors.affiliation: Graduate Institute of Biotechnology, Chinese Culture University, YangMingShan, Taipei 11114, Taiwan, R.O.C.
authors.forename: Pung-Ling
authors.initials: PL
authors.lastname: Huang
authors.affiliation: Department of Horticulture and Landscape Architecture, National Taiwan University, Taipei 10617, Taiwan, R.O.C.
authors.forename: Yi-Yin
authors.initials: YY
authors.lastname: Do
authors.affiliation: Graduate Institute of Biotechnology, Chinese Culture University, YangMingShan, Taipei 11114, Taiwan, R.O.C.
authors.forename: Yen-Chang
authors.initials: YC
authors.lastname: Lin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D006332:Cardiomegaly / Q000188:drug therapy* / Q000209:etiology; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D004149:Dioxoles / Q000494:pharmacology / Q000627:therapeutic use*; D004562:Electrocardiography; D006321:Heart / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D017705:Lignans / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009206:Myocardium / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000633:toxicity
chemical_list: D001786:Blood Glucose; D004149:Dioxoles; D017705:Lignans; D013311:Streptozocin; C054125:sesamin