title: Diagnostic Ability of Wide-field Retinal Nerve Fiber Layer Maps Using Swept-Source Optical Coherence Tomography for Detection of Preperimetric and Early Perimetric Glaucoma.
abstract: OBJECTIVE
  To evaluate the diagnostic ability of wide-field retinal nerve fiber layer (RNFL) maps with swept-source optical coherence tomography (SS-OCT) for detection of preperimetric (PPG) and early perimetric glaucoma (EG).
  
  
  METHODS
  One hundred eighty-four eyes, including 67 healthy eyes, 43 eyes with PPG, and 74 eyes with EG, were analyzed. Patients underwent a comprehensive ocular examination including red-free RNFL photography, visual field testing and wide-field SS-OCT scanning (DRI-OCT-1 Atlantis; Topcon, Tokyo, Japan). SS-OCT provides a wide-field RNFL thickness map and a SuperPixel map, which are composed of the RNFL deviation map of the peripapillary area and the deviation map of the composition of the ganglion cell layer with the inner plexiform layer and RNFL (GC-IPL+RNFL) in the macular area. The ability to discriminate PPG and EG from healthy eyes was assessed using sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) for all parameters and criteria provided by the wide-field SS-OCT scan.
  
  
  RESULTS
  The wide-field RNFL thickness map using SS-OCT showed the highest sensitivity of PPG-diagnostic and EG-diagnostic performance compared with the other SS-OCT criteria based on the internal normative base (93.0 and 97.3%, respectively). Among the SS-OCT continuous parameters, the RFNL thickness of the 7 clock-hour, inferior and inferotemporal macular ganglion cell analyses showed the largest AUC of PPG-diagnostic and EG-diagnostic performance (AUC=0.809 to 0.865).
  
  
  CONCLUSIONS
  The wide-field RNFL thickness map using SS-OCT performed well in distinguishing eyes with PPG and EG from healthy eyes. In the clinical setting, wide-field RNFL maps of SS-OCT can be useful tools for detection of early-stage glaucoma.
authors.affiliation: *Department of Ophthalmology, Seoul National University College of Medicine †Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Won June
authors.initials: WJ
authors.lastname: Lee
authors.forename: Kyeong Ik
authors.initials: KI
authors.lastname: Na
authors.forename: Young Kook
authors.initials: YK
authors.lastname: Kim
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Jeoung
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007429:Intraocular Pressure; D007564:Japan; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D012372:ROC Curve; D012160:Retina / Q000000981:diagnostic imaging*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields