title: Selenium Administration Attenuates 5-Flurouracil-Induced Intestinal Mucositis.
abstract: Chemotherapy-induced mucositis is mediated by the release of proinflammatory cytokines and reactive oxygen species. Selenium has several metabolic functions, including the protection of membrane lipids and macromolecules against oxidative damage. However, to date, there is little evidence on the effect of trace elements on intestinal mucositis after chemotherapy. This study investigated the protective effect of selenium against chemotherapy-induced mucositis in rats. Twenty-four 9-wk-old female Wistar rats were randomized to 4 groups: control, selenium, 5-fluorouracil (5-FU), and 5-FU plus selenium. Mucositis was induced by a single dose of 5-FU (400 mg/kg BW) via intraperitoneal injection, and selenium was administered by a single intraperitoneal dose of sodium selenite (0.2 mg/kg BW). Diarrhea and weight loss after 5-FU administration were attenuated by selenium treatment. The mean villus height in the 5-FU plus selenium group was significantly taller than rats administered with 5-FU alone, but not significantly different compared to the control group. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α mRNA expression were significantly lower in the 5-FU plus selenium group than in the 5-FU only group (IL-1β, P < 0.01; TNF-α, P < 0.05). These findings indicate that selenium protects the mucosa during chemotherapy via its anti-inflammatory effects and its suppression of cytotoxic cytokine production.
authors.affiliation: a Division of Gastroenterology and Hepatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: a Division of Gastroenterology and Hepatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.
authors.forename: Hoon Jai
authors.initials: HJ
authors.lastname: Chun
authors.affiliation: a Division of Gastroenterology and Hepatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.
authors.forename: Hyuk Soon
authors.initials: HS
authors.lastname: Choi
authors.affiliation: a Division of Gastroenterology and Hepatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Kim
authors.affiliation: a Division of Gastroenterology and Hepatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.
authors.forename: Yeon Seok
authors.initials: YS
authors.lastname: Seo
authors.affiliation: a Division of Gastroenterology and Hepatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.
authors.forename: Yoon Tae
authors.initials: YT
authors.lastname: Jeen
authors.affiliation: a Division of Gastroenterology and Hepatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.
authors.forename: Hong Sik
authors.initials: HS
authors.lastname: Lee
authors.affiliation: a Division of Gastroenterology and Hepatology, Department of Internal Medicine , Korea University College of Medicine , Seoul , Republic of Korea.
authors.forename: Soon Ho
authors.initials: SH
authors.lastname: Um
authors.affiliation: b Department of Pathology , Korea University Anam Hospital , Seoul , Republic of Korea.
authors.forename: Chul Hwan
authors.initials: CH
authors.lastname: Kim
authors.affiliation: c Graduate School of Medicine , Korea University , Seoul , Republic of Korea.
authors.forename: Donggeun
authors.initials: D
authors.lastname: Sul
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D016207:Cytokines / Q000235:genetics; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D005786:Gene Expression Regulation / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D052016:Mucositis / Q000139:chemically induced* / Q000188:drug therapy* / Q000235:genetics; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D015431:Weight Loss / Q000187:drug effects
chemical_list: D000975:Antioxidants; D016207:Cytokines; D012643:Selenium; D005472:Fluorouracil