title: Does Acute Normobaric Hypoxia Induce Anapyrexia in Adult Humans?
abstract: Seo, Yongsuk, Hayden D. Gerhart, Jeremiah Vaughan, Jung-Hyun Kim, and Ellen L. Glickman. Does acute normobaric hypoxia induce anapyrexia in adult humans? High Alt Med Biol. 18:185-190, 2017.-Exposure to hypoxia is known to induce a reduction in core body temperature as a protective mechanism, which has been shown in both animals and humans. The purpose of this study was to test if acute exposure to normobaric hypoxia (NH) induces anapyrexia in adult humans in association with decreased peripheral oxygen saturation (SpO2). Ten healthy male subjects were seated in atmospheres of normobaric normoxia 21% (NN21), NH 17% (NH17), and 13% (NH13) O2for 60 minutes in a counterbalanced manner. Rectal temperature (Tre) was continuously monitored together with the quantification of metabolic heat production (MHP) and body heat storage (S). Baseline physiological measurements showed no differences between the three conditions. SpO2was significantly decreased in NH17 and NH13 compared with NN21 (p ≤ 0.001). Tre decreased following 60 minutes of resting in all conditions, but, independent of the conditions, showed no association between Tre and levels of hypoxic SpO2. There was also no significant difference in either MHP or S between conditions. The present results showed no evidence of hypoxia-induced anapyrexia in adult humans during 1 hour of resting after exposure to NH either at 13% or 17% O2.
authors.affiliation: 1 Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health , National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania.
authors.forename: Yongsuk
authors.initials: Y
authors.lastname: Seo
authors.affiliation: 2 Department of Exercise Physiology, Kent State University , Kent, Ohio.|3 Kinesiology, Health, and Sport Science, Indiana University of Pennsylvania , Indiana, Pennsylvania.
authors.forename: Hayden D
authors.initials: HD
authors.lastname: Gerhart
authors.affiliation: 2 Department of Exercise Physiology, Kent State University , Kent, Ohio.
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Vaughan
authors.affiliation: 1 Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health , National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania.
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: 2 Department of Exercise Physiology, Kent State University , Kent, Ohio.
authors.forename: Ellen L
authors.initials: EL
authors.lastname: Glickman
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000502:physiology*; D064368:Healthy Volunteers; D006801:Humans; D007035:Hypothermia / Q000209:etiology*; D000860:Hypoxia / Q000150:complications* / Q000503:physiopathology; D008297:Male; D012146:Rest / Q000502:physiology
keywords: body temperature; heat storage; hypoxia; metabolic heat production