title: Autophagy: It's in Your Blood.
abstract: Autophagy, a central pathway for cellular homeostasis, plays diverse roles in development, cancer, aging, and neurodegeneration. In a new report in Nature, Ho et al. (2017) show that autophagy is essential for maintaining the replicative quiescence of hematopoietic stem cells throughout life by limiting the number of active mitochondria.
authors.affiliation: Division of Hematology, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address: doulatov@uw.edu.
authors.forename: Sergei
authors.initials: S
authors.lastname: Doulatov
authors.affiliation: Division of Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
authors.forename: George Q
authors.initials: GQ
authors.lastname: Daley
mesh_terms: D000375:Aging; D001343:Autophagy; D006412:Hematopoietic Stem Cells; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria