title: Omics Approaches to Identify Potential Biomarkers of Inflammatory Diseases in the Focal Adhesion Complex.
abstract: Inflammatory diseases such as inflammatory bowel disease (IBD) require recurrent invasive tests, including blood tests, radiology, and endoscopic evaluation both to diagnose and assess disease activity, and to determine optimal therapeutic strategies. Simple 'bedside' biomarkers could be used in all phases of patient management to avoid unnecessary investigation and guide further management. The focal adhesion complex (FAC) has been implicated in the pathogenesis of multiple inflammatory diseases, including IBD, rheumatoid arthritis, and multiple sclerosis. Utilizing omics technologies has proven to be an efficient approach to identify biomarkers from within the FAC in the field of cancer medicine. Predictive biomarkers are paving the way for the success of precision medicine for cancer patients, but inflammatory diseases have lagged behind in this respect. This review explores the current status of biomarker prediction for inflammatory diseases from within the FAC using omics technologies and highlights the benefits of future potential biomarker identification approaches.
authors.affiliation: Gut Health and Food Safety Institute Strategic Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom; Gastroenterology Department, Norfolk and Norwich University Hospital, Norwich NR4 7UY, United Kingdom.
authors.forename: Johanne
authors.initials: J
authors.lastname: Brooks
authors.affiliation: Gut Health and Food Safety Institute Strategic Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom; Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom; Gastroenterology Department, Norfolk and Norwich University Hospital, Norwich NR4 7UY, United Kingdom.
authors.forename: Alastair
authors.initials: A
authors.lastname: Watson
authors.affiliation: Gut Health and Food Safety Institute Strategic Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom; Earlham Institute, Norwich Research Park, Norwich NR4 7UZ, United Kingdom. Electronic address: Tamas.Korcsmaros@earlham.ac.uk.
authors.forename: Tamas
authors.initials: T
authors.lastname: Korcsmaros
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers; D022001:Focal Adhesions / Q000378:metabolism*; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D057285:Precision Medicine; D040901:Proteomics; D049490:Systems Biology
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Focal adhesion complex; Inflammation; Omics; Systems biology