title: BIOPHYSICAL PROPERTIES OF SUBTHRESHOLD RESONANCE OSCILLATIONS AND SUBTHRESHOLD MEMBRANE OSCILLATIONS IN NEURONS.
abstract: Subthreshold-level activities in neurons play a crucial role in neuronal oscillations. These small-amplitude oscillations have been suggested to be involved in synaptic plasticity and in determining the frequency of network oscillations. Subthreshold membrane oscillations (STOs) and subthreshold resonance oscillations (SROs) are the main constituents of subthreshold-level activities in neurons. In this study, a general theoretical framework for analyzing the mechanisms underlying STOs and SROs in neurons is presented. Results showed that the resting membrane potential and the hyperpolarization-activated potassium channel (h-channel) affect the subthreshold-level activities in stellate cells. The contribution ofh-channel on resonance is attributed to its large time constant, which produces the time lag betweenIhand the membrane potential. Conversely, the persistent sodium channels (Nap-channels) only play an amplifying role in these neurons.
authors.affiliation: Departments of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH, USA.
authors.forename: Babak
authors.initials: B
authors.lastname: V-Ghaffari
authors.affiliation: Malaysia-Japan International Institute of Technology, UTM, Kuala Lumpur, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Kouhnavard
authors.affiliation: Malaysia-Japan International Institute of Technology, UTM, Kuala Lumpur, Malaysia.
authors.forename: T
authors.initials: T
authors.lastname: Kitajima
keywords: Biophysical Model; Conductance-Based Model; Equivalent RLC Circuit; Stellate Cells; Subthreshold Membrane Oscillation; Subthreshold Resonance Oscillation