title: Iron assimilation and utilization in anaerobic ammonium oxidizing bacteria.
abstract: The most abundant transition metal in biological systems is iron. It is incorporated into protein cofactors and serves either catalytic, redox or regulatory purposes. Anaerobic ammonium oxidizing (anammox) bacteria rely heavily on iron-containing proteins - especially cytochromes - for their energy conservation, which occurs within a unique organelle, the anammoxosome. Both their anaerobic lifestyle and the presence of an additional cellular compartment challenge our understanding of iron processing. Here, we combine existing concepts of iron uptake, utilization and metabolism, and cellular fate with genomic and still limited biochemical and physiological data on anammox bacteria to propose pathways these bacteria may employ.
authors.affiliation: Department of Microbiology, Institute for Water and Wetland Research, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
authors.forename: Christina
authors.initials: C
authors.lastname: Ferousi
authors.affiliation: Department of Microbiology, Institute for Water and Wetland Research, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
authors.forename: Simon
authors.initials: S
authors.lastname: Lindhoud
authors.affiliation: Laboratoire de Bioénergétique et Ingénierie des Protéines UMR 7281 CNRS/AMU, FR3479, Marseille Cedex 20 13402, France.
authors.forename: Frauke
authors.initials: F
authors.lastname: Baymann
authors.affiliation: Microbial Physiology Group, Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, 28359 Bremen, Germany.
authors.forename: Boran
authors.initials: B
authors.lastname: Kartal
authors.affiliation: Department of Microbiology, Institute for Water and Wetland Research, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands; Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands; Soehngen Institute of Anaerobic Microbiology, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
authors.forename: Mike Sm
authors.initials: MS
authors.lastname: Jetten
authors.affiliation: Department of Microbiology, Institute for Water and Wetland Research, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. Electronic address: j.reimann@science.ru.nl.
authors.forename: Joachim
authors.initials: J
authors.lastname: Reimann
mesh_terms: D064751:Ammonium Compounds / Q000378:metabolism*; D001421:Bacteria, Anaerobic / Q000378:metabolism*; D001692:Biological Transport; D003067:Coenzymes / Q000096:biosynthesis; D007501:Iron / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D064751:Ammonium Compounds; D003067:Coenzymes; D007501:Iron