title: Mechanisms controlling diversification of olfactory sensory neuron classes.
abstract: Animals survive in harsh and fluctuating environments using sensory neurons to detect and respond to changes in their surroundings. Olfactory sensory neurons are essential for detecting food, identifying danger, and sensing pheromones. The ability to sense a large repertoire of different types of odors is crucial to distinguish between different situations, and is achieved through neuronal diversity within the olfactory system. Here, we review the developmental mechanisms used to establish diversity of olfactory sensory neurons in various model organisms, including Caenorhabditis elegans, Drosophila, and vertebrate models. Understanding and comparing how different olfactory neurons develop within the nervous system of different animals can provide insight into how the olfactory system is shaped in humans.
authors.affiliation: Department of Biological Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, MC 567, Chicago, IL, 60607, USA.
authors.forename: Yi-Wen
authors.initials: YW
authors.lastname: Hsieh
authors.affiliation: Department of Biological Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, MC 567, Chicago, IL, 60607, USA.
authors.forename: Amel
authors.initials: A
authors.lastname: Alqadah
authors.affiliation: Department of Biological Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, MC 567, Chicago, IL, 60607, USA. chioufen.chuang@gmail.com.
authors.forename: Chiou-Fen
authors.identifier: 0000-0001-7469-076X
authors.initials: CF
authors.lastname: Chuang
mesh_terms: D000818:Animals; D002450:Cell Communication; D004742:Enhancer Elements, Genetic / Q000235:genetics; D044127:Epigenesis, Genetic; D018034:Olfactory Receptor Neurons / Q000145:classification / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism; D018035:Receptors, Odorant / Q000235:genetics / Q000378:metabolism; D012903:Smell / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D051880:Receptors, Notch; D018035:Receptors, Odorant; D014157:Transcription Factors
keywords: C. elegans; Combinatorial transcription factor code; Drosophila; Epigenetic regulation; G protein-coupled receptor; Stochastic neuronal asymmetry; Vertebrate