title: Distribution and antifungal susceptibility of yeasts isolates from intensive care unit patients.
abstract: Yeasts frequently colonize non-sterile sites in the body. The aim of the study was to determine distribution in clinical samples and antifungal susceptibility to five antifungals. From January 2013 through June 2015, 800 isolates were obtained from intensive care unit patients. Candida albicans (58.9%), Candida glabrata (20.4%), Candida krusei (8.6%), and Candida parapsilosis (3.6%) were the leading species. Majority of the C. albicans isolates were susceptible to the fluconazole. Elevated voriconazole minimal inhibitory concentrations (MICs) were observed in isolates exhibiting high fluconazole MICs, most frequently in C. glabrata. Isolates with echinocandins MICs suggesting reduced susceptibility were only sporadic cases with the exception of Trichosporon spp. The amphotericin B MICs were slightly higher for some C. krusei.
authors.affiliation: Institute of Medical and Clinical Microbiology, P. J. Šafárik University, Faculty of Medicine and L. Pasteur University Hospital, Košice, Slovakia. vladimir.hrabovsky@upjs.sk.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Hrabovský
authors.affiliation: Institute of Medical and Clinical Microbiology, P. J. Šafárik University, Faculty of Medicine and L. Pasteur University Hospital, Košice, Slovakia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Takáčová
authors.affiliation: Institute of Medical and Clinical Microbiology, P. J. Šafárik University, Faculty of Medicine and L. Pasteur University Hospital, Košice, Slovakia.
authors.forename: Eva
authors.initials: E
authors.lastname: Schréterová
authors.affiliation: Institute of Medical and Clinical Microbiology, P. J. Šafárik University, Faculty of Medicine and L. Pasteur University Hospital, Košice, Slovakia.
authors.forename: Lydia
authors.initials: L
authors.lastname: Pastvová
authors.affiliation: Department of Dermatovenerology, P. J. Šafárik University, Faculty of Medicine and L. Pasteur University Hospital, Košice, Slovakia.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Hrabovská
authors.affiliation: Institute of Medical and Clinical Microbiology, P. J. Šafárik University, Faculty of Medicine and L. Pasteur University Hospital, Košice, Slovakia.
authors.forename: Katarina
authors.initials: K
authors.lastname: Čurová
authors.affiliation: Institute of Medical and Clinical Microbiology, P. J. Šafárik University, Faculty of Medicine and L. Pasteur University Hospital, Košice, Slovakia.
authors.forename: Leonard
authors.initials: L
authors.lastname: Siegfried
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D008826:Microbial Sensitivity Tests; D065819:Voriconazole / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole; D065819:Voriconazole
keywords: Antifungal Drug; Caspofungin; Invasive Fungal Infection; Triazole; Voriconazole