title: Lectin, galactoside-binding, soluble, 3 rs4652 A/C gene variation and the risk for rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is a complex genetic disease. The lectin, galactoside-binding, soluble, 3 (LGALS3) gene, encodes a member of the galectin family of carbohydrate binding proteins, and is one of the best examples of a non-human leukocyte antigen gene associated with a risk for RA in various populations. In the current study, the association between LGALS3 rs4652 gene polymorphism and RA was examined. This case-control study was performed on the 120 patients with RA and 120 healthy subjects. Genomic DNA was extracted from whole blood, and gene polymorphism was tested using a tetra-primer amplification refractory mutation system-polymerase chain reaction. The results demonstrated that LGALS3 rs4652 AC genotype increased the risk of RA (OR=11.622, 95% CI=4.473-28.656; P=0.001) when compared with the AA genotype. However, the CC genotype and the C allele were not associated with RA. These findings indicated an association between LGALS3 rs4652 variation and the risk of RA in a sample of Iranian individuals. Further studies with larger sample sizes and populations of different ethnicities are required to validate our findings.
authors.affiliation: Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 98167-43181, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Atabaki
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 98167-43181, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Department of Immunology, Kerman University of Medical Sciences, Kerman, Kerman 76169-14115, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Daneshvar
authors.affiliation: Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 98167-43181, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Alijani
keywords: 3; galactoside-binding; lectin; polymorphism; rheumatoid arthritis; soluble