title: Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata).
abstract: A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos.
  
  
  
  The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia.
  
  
  
  The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain. Histopathological and immunohistological examinations revealed that the masses were hepatocellular carcinoma (HCC) and a metastatic lesion. In both the primary and metastatic lesions, neoplastic hepatocytes were arranged mainly in a trabecular pattern. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3 and CAM5.2) and hepatocyte paraffin 1 and negative for cytokeratin 7 and 20 and vimentin.
  
  
  
  To our knowledge, this is the first case report of HCC with intracranial metastasis in a macaque.
authors.affiliation: Primate Research Institute, Kyoto University, Aichi, Japan.
authors.forename: Takako
authors.identifier: 0000-0001-6502-655X
authors.initials: T
authors.lastname: Miyabe-Nishiwaki
authors.affiliation: Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hirata
authors.affiliation: Primate Research Institute, Kyoto University, Aichi, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Kaneko
authors.affiliation: Primate Research Institute, Kyoto University, Aichi, Japan.
authors.forename: Akiyo
authors.initials: A
authors.lastname: Ishigami
authors.affiliation: Primate Research Institute, Kyoto University, Aichi, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Miyamoto
authors.affiliation: Primate Research Institute, Kyoto University, Aichi, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamanaka
authors.affiliation: Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
authors.forename: Keishi
authors.initials: K
authors.lastname: Owaki
authors.affiliation: Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sakai
authors.affiliation: Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
authors.forename: Tokuma
authors.initials: T
authors.lastname: Yanai
authors.affiliation: Primate Research Institute, Kyoto University, Aichi, Japan.
authors.forename: Juri
authors.initials: J
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000662:veterinary*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary; D008251:Macaca; D008297:Male; D008992:Monkey Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000662:veterinary