title: Thyroid function/antibodies in sudanese women with polycystic ovarian disease.
abstract: OBJECTIVE
  To evaluate thyroid function and hormonal profile in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  A case-control study was conducted at Saad Abualila Center, Khartoum, Sudan. The cases were women with confirmed PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history were gathered using a questionnaire. Thyroid hormones (thyroid-stimulating hormone, free tri-iodothyronine, and free thyroxine), anti-thyroid peroxidase, and anti-thyroglobulin antibodies were measured.
  
  
  RESULTS
  While there were no significant differences in the age and haemoglobin levels of the two studied groups (55 women in each arm), body mass index was significantly higher in women with PCOS. There were no significant differences in the levels of thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone, luteinizing hormone/follicle stimulating hormone, anti-thyroid peroxidase, anti-thyroglobulin antibodies, cholesterol, triglycerides and low-density lipoprotein cholesterol between the cases and the controls. The mean±standard deviation of free tri-iodothyronine (3.50±0.2 vs. 3.38±0.3 pg/mL,P=0.040) and median (interquartile) high-density lipoprotein cholesterol (37.0 [34.0 to 42.0] vs. 35.80 [29.0 to 41.0] mg/dL,P=0.015) were significantly higher in PCOS patients compared with the control group. In linear regression, PCOS (0.151 pg/mL,P=0.023) and anti-thyroid peroxidase levels (-0.078 pg/mL,P=0.031) were significantly associated with free tri-iodothyronine.
  
  
  CONCLUSIONS
  Free tri-iodothyronine was a significantly higher among PCOS patients compared with the control group.
authors.affiliation: Faculty of Medicine and Health Sciences, Al-Neelain University, Khartoum, Sudan.
authors.forename: Shaza
authors.initials: S
authors.lastname: Mohammed
authors.affiliation: Faculty of Medicine and Health Sciences, Al-Neelain University, Khartoum, Sudan.
authors.forename: Hiba A
authors.initials: HA
authors.lastname: Awooda
authors.affiliation: Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
authors.forename: Duria A
authors.initials: DA
authors.lastname: Rayis
authors.affiliation: Faculty of Medicine and Health Sciences, Al-Neelain University, Khartoum, Sudan.
authors.forename: Hamdan Z
authors.initials: HZ
authors.lastname: Hamdan
authors.affiliation: Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
authors.forename: Ishag
authors.identifier: 0000-0001-5031-7741
authors.initials: I
authors.lastname: Adam
authors.affiliation: Faculty of Medicine and Health Sciences, Al-Neelain University, Khartoum, Sudan.
authors.forename: Mohamed F
authors.initials: MF
authors.lastname: Lutfi
keywords: Infertility; Polycystic ovary syndrome; Sudan; Thyroid hormone; Thyroid peroxidase antibodies