title: Effects of the Oral Administration of K2Cr2O7and Na2SeO3on Ca, Mg, Mn, Fe, Cu, and Zn Contents in the Heart, Liver, Spleen, and Kidney of Chickens.
abstract: This study aimed to investigate the effects of selenium on the ion profiles in the heart, liver, spleen, and kidney through the oral administration of hexavalent chromium. Approximately 22.14 mg/kg b.w. K2Cr2O7was added to water to establish a chronic poisoning model. Different selenium levels (0.00, 0.31, 0.63, 1.25, 2.50, and 5.00 mg Na2SeO3/kg b.w.) around the safe dose were administered to the experimental group model. Ca, Mg, Mn, Fe, Cu, and Zn were detected in the organs through flame atomic absorption spectrometry after these organs were exposed to K2Cr2O7and Na2SeO3for 14, 28, and 42 days. Results showed that these elements exhibited various changes. Ca contents declined in the heart, liver, and spleen. Ca contents also decreased on the 28th day and increased on the 42nd day in the kidney. Mn contents declined in the heart and spleen but increased in the kidney. Mn contents also decreased on the 28th day and increased on the 42nd day in the liver. Cu contents declined in the heart and spleen. Cu contents increased on the 28th day and decreased on the 42nd day in the liver and kidney. Zn contents declined in the heart and spleen. Zn contents increased on the 28th day and decreased on the 42nd day in the liver and kidney. Fe contents decreased in the heart and liver. Fe contents increased on the 28th day and decreased on the 42nd day in the spleen and kidney. Mg contents did not significantly change in these organs. Appropriate selenium contents enhanced Mn and Zn contents, which were declined by chromium. Conversely, appropriate selenium contents reduced Ca, Fe, and Cu contents, which were increased by chromium. In conclusion, the exposure of chickens to K2Cr2O7induced changes in different trace elements, and Na2SeO3supplementation could alleviate this condition.
authors.affiliation: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China.
authors.forename: Yiran
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China.
authors.forename: Huiyu
authors.initials: H
authors.lastname: Wan
authors.affiliation: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Hao
authors.affiliation: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China.
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China.
authors.forename: Yongxia
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Research Center for Animal Disease Control Engineering, Shandong Agricultural University, Tai'an, Shandong Province, 271018, China. Liujz@sdau.edu.cn.
authors.forename: Jianzhu
authors.initials: J
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017849:Animals, Inbred Strains; D002645:Chickens; D002681:China; D002857:Chromium / Q000008:administration & dosage / Q000737:chemistry / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D000075322:Heavy Metal Poisoning / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011192:Potassium Dichromate / Q000008:administration & dosage; D011201:Poultry Diseases / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D020011:Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D018038:Sodium Selenite / Q000008:administration & dosage / Q000627:therapeutic use*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D014131:Trace Elements / Q000172:deficiency / Q000378:metabolism*; D014883:Water-Electrolyte Imbalance / Q000209:etiology / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D020011:Protective Agents; D014131:Trace Elements; D002857:Chromium; D018038:Sodium Selenite; D011192:Potassium Dichromate
keywords: Chicken; Hexavalent chromium; Organs; Selenium; Trace element