title: Pre-surgery exercise and post-operative physical function of people undergoing knee replacement surgery: A systematic review and meta-analysis of randomized controlled trials.
abstract: OBJECTIVE
  To summarize the evidence regarding the effectiveness and dose-response characteristics of pre-operative exercise programmes on post-operative physical function following total knee arthroplasty.
  
  
  METHODS
  CINAHL, Cochrane Library, PubMed, SPORTDiscus and EMBASE.
  
  
  METHODS
  Randomized controlled trials were eligible if they provided full description of physiological stress (i.e. mode, frequency, intensity and duration).
  
  
  METHODS
  Data extraction and evaluation were performed by one reviewer. Methodological quality of the selected studies was assessed using the Physiotherapy Evidence Database scale.
  
  
  RESULTS
  Twelve candidate studies were identified, but only 3 papers satisfied all inclusion criteria: 2 studies evaluated the effect of resistance training and 1 trial investigated proprioceptive training. The latter study elicited significantly enhanced post-operative gains in function for indices of standing balance (overall stability index: Hedges' g = -1; anteroposterior stability index: Hedges' g = -1.15; 6 weeks post-surgery). Results of meta-analysis based on the findings of 2 studies showed that, compared with controls, prehabilitative exercise involving resistance training offered no additional gains in isometric quadriceps muscle strength at 6 and 12 weeks post-operatively.
  
  
  CONCLUSIONS
  Despite a potential for efficacy of exercise-based conditioning, this review highlights the scarcity of robust dose-response evidence to guide the formulation of total knee arthroplasty prehabilitation effectively.
authors.affiliation: School of Health Sciences, Queen Margaret University, EH21 6UU Edinburgh, United Kingdom. mpeer@qmu.ac.uk.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Peer
authors.forename: Robert
authors.initials: R
authors.lastname: Rush
authors.forename: Peter D
authors.initials: PD
authors.lastname: Gallacher
authors.forename: Nigel
authors.initials: N
authors.lastname: Gleeson
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000534:rehabilitation*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic