title: Cassia fistula: A remedy from Traditional Persian Medicine for treatment of cutaneous lesions of pemphigus vulgaris.
abstract: OBJECTIVE
  Pemphigus is a rare autoimmune disease that may be fatal without proper medical intervention. It is a blistering disease that involves both the skin and mucus membranes, in which the most important causes of death comprise superimposed opportunistic infections and complications of long-term high-dose corticosteroid therapy or prolonged consumption of immune suppressant drugs. Skin lesions are the most important sources of infection, and any local treatment decreasing the healing time of lesions and reducing the total dosage of drugs is favorable.
  
  
  METHODS
  Here, we review the probable mechanism of action of a traditional formulary ofCassia fistula(C. fistula) fruit extract in almond oil as a new topical medication for reducing the duration of treatment of pemphigus vulgaris erosions.
  
  
  RESULTS
  C. fistulafruit oil has lupeol, anthraquinone compounds as rhein and flavonoids. Previousin vitroand animal studies onC. fistulafruit have demonstrated wound healing, antioxidative, anti-leukotrienes, anti-inflammatory, antibacterial and antifungal effects of this plant.
  
  
  CONCLUSIONS
  It is hypothesized thatC. fistulaL. can be a botanical therapeutic choice for treatment of pemphigus erosions.
authors.affiliation: Department of Traditional Iranian Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Atarzadeh
authors.affiliation: School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kamalinejad
authors.affiliation: Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ladan
authors.initials: L
authors.lastname: Dastgheib
authors.affiliation: Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Amin
authors.affiliation: Department of Traditional Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Amir Mohammad
authors.initials: AM
authors.lastname: Jaladat
authors.affiliation: Department of Traditional Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Nimrouzi