title: Association between the DNA Repair Gene XRCC3 rs861539 Polymorphism and Risk of Osteosarcoma: a Systematic Review and Meta-Analysis
abstract: Objective: Although there are a few studies investigating the relation between X-Ray Repair Cross Complementing 3
  (XRCC3) gene rs861539 polymorphism and osteosarcoma (OSA), the results are inconsistent. Therefore, we performed
  this systematic review and meta-analysis to clarify the associations between XRCC3 rs861539 polymorphism and OSA
  risk. Methods: We have retrieved published literature from PubMed, Google scholar, and ISI Web of Knowledge up to
  25 January 2017. Odds ratios were pooled using either fixed-effects or random effects models. Overall and subgroup
  analyses were performed. Statistical analysis was performed running comprehensive meta-analysis (CMA) 2.0 software.
  Results: A total of four studies with 515 cases and 1,109 controls were identified in order to investigate the association
  between XRCC3 rs861539 polymorphism and OSA risk. The results showed that XRCC3 rs861539 polymorphism
  was associated with OSA in allelic (T vs. C: OR= 1.563, 95% CI: 1.244-1.963, p= <0.001), homozygote (TT vs. CC:
  OR= 2.574, 95% CI: 1.573-4.212, p= <0.001), dominant (TT+TC vs. CC: OR= 1.255, 95% CI: 1.011-1.558, p= 0.039),
  and recessive (TT vs. TC+CC: OR= 2.224, 95% CI: 1.393-3.552, p= 0.001), but not with heterozygote (TC vs. CC:
  OR= 1.361, 95% CI: 0.982-1.885, p= 0.064). The XRCC3 rs861539 polymorphism conferred susceptibility to OSA in
  Asians, but not in Caucasians. Additionally, we observed no evidence of publication bias. Conclusion: To the best of
  our knowledge, this is the first meta-analysis investigating the association between XRCC3 rs861539 polymorphism
  and OSA risk. Our results revealed a significant association between the XRCC3 rs861539 polymorphism and risk of
  OSA, especially in Asian populations. Future more comprehensive and well-designed case control studies with larger
  sample size are needed to warrant these findings.
authors.affiliation: Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 
  Email: mohammad.foratyazdi@gmail.com
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Sobhan
authors.forename: Mohammad
authors.initials: M
authors.lastname: Forat Yazdi
authors.forename: Mahta
authors.initials: M
authors.lastname: Mazaheri
authors.forename: Masoud
authors.initials: M
authors.lastname: Zare Shehneh
authors.forename: Hossein
authors.initials: H
authors.lastname: Neamatzadeh
keywords: Osteosarcoma; XRCC3; rs861539 polymorphism; meta-analysis