title: Cytomegalovirus Retinitis: A Review.
abstract: Cytomegalovirus (CMV) is a ubiquitous DNA herpes virus that causes significant morbidity and mortality in immunocompromised individuals. CMV retinitis is a potentially blinding manifestation of CMV infection that was commonly seen in advanced acquired immunodeficiency syndrome (AIDS) in the era before modern combination antiretroviral therapy era, but is also recognized in patients with immune deficiency from multiple causes. The advent of and advances in antiretroviral therapies for human immunodeficiency virus have decreased the incidence of CMV retinitis by over 90% among AIDS patients, and improved visual outcomes in those affected. The diagnosis is generally a clinical one, and treatment modalities include systemic and intravitreal antiviral medications. Retinal detachment and immune recovery uveitis are sight-threatening complications of CMV retinitis that require specific treatments.
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital , New York, New York.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Port
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital , New York, New York.
authors.forename: Anton
authors.initials: A
authors.lastname: Orlin
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital , New York, New York.
authors.forename: Szilard
authors.initials: S
authors.lastname: Kiss
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital , New York, New York.
authors.forename: Sarju
authors.initials: S
authors.lastname: Patel
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital , New York, New York.
authors.forename: Donald J
authors.initials: DJ
authors.lastname: D'Amico
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital , New York, New York.
authors.forename: Mrinali P
authors.initials: MP
authors.lastname: Gupta
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D017726:Cytomegalovirus Retinitis / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology*; D006801:Humans
chemical_list: D000998:Antiviral Agents
keywords: cytomegalovirus; immune recovery uveitis; retinitis