title: A Clinical Study Protocol to Identify Serum Biomarkers Predictive of Response to Antipsychotics in Schizophrenia Patients.
abstract: An increasing number of studies are now exploring the potential of using blood-based biomarkers for prediction of antipsychotic treatment response in studies of schizophrenia patients. Here we describe the detailed setup of a clinical study to identify biomarker candidates for prediction of response of patients prior to receiving antipsychotics over a 6-week treatment period. The main emphasis is on study design, patient recruitment, sampling and outcome measures.
authors.affiliation: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany. johann.steiner@med.ovgu.de.
authors.forename: Johann
authors.initials: J
authors.lastname: Steiner
authors.affiliation: Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, Campinas, Brazil.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D015415:Biomarkers
keywords: Antipsychotics; Biomarkers; Multiplex immunoassay; PANSS; Proteomics; Schizophrenia; Treatment response