title: Fabrication of self-setting β-tricalcium phosphate granular cement.
abstract: Bone defect reconstruction would be greatly improved if β-tricalcium phosphate (β-TCP) granules had the ability to self-set without sacrificing their osteoconductivity potential. This study aimed to identify a method to permit β-TCP self-setting whilst maintaining good osteoconductivity. When mixed with acidic calcium phosphate solution, β-TCP granules were found to readily set, forming a fully interconnected porous structure. On mixing, dicalcium phosphate dihydrate crystals formed on the surface of β-TCP granules, bridging the granules and resulting in the setting reaction. The setting time of the β-TCP granular cement (β-TCP GC) was approximately 1 min and its mechanical strength, in terms of diametral tensile strength, was approximately 0.8 MPa. The β-TCP GC and β-TCP granules both showed the same level of osteoconductivity within rat calvaria bone defects. At 2 and 4 weeks post-implantation, new bone formation was comparable between the two β-TCP based bone substitutes. We conclude that β-TCP GC has excellent potential for use as a cement in bone defect reconstruction. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 800-807, 2018.
authors.affiliation: Department of Biomaterials, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan.|Division of Maxillofacial Diagnostic and Surgical Sciences, Section of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Fukuda
authors.affiliation: Department of Biomaterials, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Kanji
authors.initials: K
authors.lastname: Tsuru
authors.affiliation: Division of Maxillofacial Diagnostic and Surgical Sciences, Section of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Mori
authors.affiliation: Department of Biomaterials, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D001843:Bone Cements / Q000737:chemistry / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000293:injuries / Q000378:metabolism / Q000473:pathology
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate
keywords: dicalcium phosphate dihydrate; granular cement; porous calcium phosphate; self-setting; β-tricalcium phosphate