title: [A retrospective analysis of clinical characteristics and outcomes of heart failure patients with different left ventricular ejection fractions].
abstract: Objective:To compare the clinical characteristics, and outcomes of patients with heart failure with different left ventricular ejection fractions (LVEF).Methods:A total of 1 182 hospitalized patients with heart failure (HF) were enrolled and retrospectively studied in the present study. The patients were stratified by LVEF as reduced (HFrEF, LVEF<40%,n=313), mid-range (HFmrEF, 40% ≤LVEF <50%,n=287) and preserved (HFpEF, LVEF≥50%,n=582) ejection fraction groups. Among the 1 182 cases, 941 of them (81.3%, 84.9%, and 84.0% inHFrEF, HFmrEF and HFpEF groups, respectively) were followed up for an median duration of 27.3 months.Results:(1) Among the study patients, 26.5% were in HFrEF, 24.3% in HFmrEF, and 49.2% in HFpEF groups. (2) Ischemic heart disease with HFmrEF was more frequent than that in patients with HFrEF. The average age, percentage of female subjects, systolic blood pressure, uric acid, N terminal B-type natriuretic peptide precursor (NT-proBNP), hemoglobin, and the incidence of hypertensive heart disease, anemia, atrial fibrillation in patients with HFmrEF were higher than those in patients with HFrEF, but lower than those in patients with HFpEF (allP<0.01). (3) The all-cause cumulative mortality was 10.8% at 1 year, 20.6% at 2 years and 35.9% at 5 years. No difference was observed in the all-cause cumulative mortality at 1 year, 2 years, 5 years among the three groups (allP>0.05).Conclusions:The HFmrEF patients, as a new and distinct group, were with many intermediate characteristics compared with HFrEF and HFpEF subjects. However, the all-cause mortality was not significantly different among HF patients with different LVEF.
authors.affiliation: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: H B
authors.initials: HB
authors.lastname: Zhou
authors.forename: D Q
authors.initials: DQ
authors.lastname: An
authors.forename: Q
authors.initials: Q
authors.lastname: Zhan
authors.forename: Z H
authors.initials: ZH
authors.lastname: Liu
authors.forename: J H
authors.initials: JH
authors.lastname: Hua
authors.forename: W Y
authors.initials: WY
authors.lastname: Lai
authors.forename: Y L
authors.initials: YL
authors.lastname: Huang
authors.forename: Q C
authors.initials: QC
authors.lastname: Zeng
authors.forename: D L
authors.initials: DL
authors.lastname: Xu
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006760:Hospitalization; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments; D012189:Retrospective Studies; D013318:Stroke Volume; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Clinical characteristics; Heart failure; Left ventricular ejection fraction; Prognosis