title: [The influence of 'potassium orotate' on neocollagenogenesis in implantation of polypropylene endoprosthesis and polypropylene combined with polylactic acid endoprosthesis].
abstract: OBJECTIVE
  To study neocollagenogenesis after implantation of polypropylene endoprosthesis and polypropylene combined with polylactic acid endoprosthesis on background of «potassium orotate» administration.
  
  
  METHODS
  We used two different types of endoprosthesis in the experiment. The first type was made of just polypropylene, the second type was made of polypropylene combined with polylactic acid. Histological examination was performed using polarizing microscopy. Collagen types I and III ratio in connective tissue around the prosthesis was analyzed according to the color that was individual for each type.
  
  
  RESULTS
  The results were significantly better in case of collagenogenesis stimulation with Potassium orotate within 30 days and later for one type of endoprosthesis. Also we revealed that collagenogenesis and paraprosthesis capsule formation were more active in case of combined endoprosthesis. We revealed stimulating action of «Potassium Orotate» for collegenogenesis process, this fact was proved by increased collagen I/III ratio.
  
  
  CONCLUSIONS
  Optimization of collagenogenesis was based on persistent 1,37-fold increase of collagen I/III ratio in case of combined endoprosthesis after 90 days. It was manifested by accelerated formation of connective tissue capsule and facilitated early isolation of the implant from surrounding tissues.
authors.affiliation: Kursk State Medical University ,Department of surgical diseases #1.
authors.forename: S V
authors.initials: SV
authors.lastname: Ivanov
authors.affiliation: Kursk State Medical University ,Department of surgical diseases #1.
authors.forename: V A
authors.initials: VA
authors.lastname: Lazarenko
authors.affiliation: Kursk State Medical University ,Department of surgical diseases #1.
authors.forename: I S
authors.initials: IS
authors.lastname: Ivanov
authors.affiliation: Kursk State Medical University ,Department of surgical diseases #1.
authors.forename: I P
authors.initials: IP
authors.lastname: Parfenov
authors.affiliation: Kursk State Medical University ,Department of surgical diseases #1.
authors.forename: A V
authors.initials: AV
authors.lastname: Tsukanov
authors.affiliation: Kursk State Medical University ,Department of surgical diseases #1.
authors.forename: D V
authors.initials: DV
authors.lastname: Tarabrin
authors.affiliation: Kursk State Medical University ,Department of surgical diseases #1.
authors.forename: E G
authors.initials: EG
authors.lastname: Ob''edkov
mesh_terms: D032761:Animal Experimentation; D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism / Q000494:pharmacology; D001682:Biological Availability; D003094:Collagen / Q000378:metabolism*; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D020007:Implants, Experimental; D051379:Mice; D009963:Orotic Acid / Q000378:metabolism / Q000494:pharmacology; D011091:Polyesters / Q000494:pharmacology*; D011126:Polypropylenes / Q000494:pharmacology*; D017680:Potassium Compounds / Q000378:metabolism / Q000494:pharmacology; D019919:Prosthesis Implantation / Q000295:instrumentation* / Q000379:methods; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011126:Polypropylenes; D017680:Potassium Compounds; C033616:poly(lactide); D009963:Orotic Acid; D003094:Collagen