title: ACP1 Genetic Polymorphism and Coronary Artery Disease: Evidence of Effects on Clinical Parameters of Cardiac Function.
abstract: BACKGROUND
  Kinases and phosphatases have an important role in the susceptibility and clinical variability of cardiac diseases. We have recently reported an association between a phosphoprotein phosphatase controlled by Acid Phosphatase locus 1 (ACP1), and Coronary artery disease (CAD) suggesting an effect on the susceptibility to this disease. In the present note we have investigated a possible role of ACP1 in the variability of clinical parameters of cardiac function.
  
  
  METHODS
  We have studied 345 subjects admitted to Valmontone Hospital for cardiovascular diseases: 202 subjects with CAD and 143 without CAD, 53 subjects admitted to Cardiac Surgery Division of Tor Vergata University were also considered.
  
  
  RESULTS
  In diabetic patients with CAD there is a significant negative association between Left ventricular ejection fraction (LVEF) and ACP1 S isoform concentration. Genotypes with high S isoform concentration show a lower value of LVEF as compared to genotypes with low S isoform concentration. We have also found a significant positive association between cNYHA class and ACP1 S isoform. After surgical intervention, in subjects with high S isoform concentration the decrease of LVEF is more marked as compared to subjects with low S isoform concentration. Overall these observations indicate that high S isoform activity has negative effects on cardiac function. The observation in patients undergoing cardiac surgery confirms the negative association between high S isoform activity and LVEF.
  
  
  CONCLUSIONS
  The present study suggests that ACP1 influences both susceptibility to CAD and clinical manifestations of the disease.
authors.affiliation: Department of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Fulvia
authors.initials: F
authors.lastname: Gloria-Bottini
authors.affiliation: Department of Cardiology, Valmontone Hospital, Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Banci
authors.affiliation: Department of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Saccucci
authors.affiliation: Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Nardi
authors.affiliation: Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Scognamiglio
authors.affiliation: Department of Cardiology, Valmontone Hospital, Rome, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Papetti
authors.affiliation: Department of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Adanti
authors.affiliation: Department of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Magrini
authors.affiliation: Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellegrino
authors.affiliation: Department of Biomedicine and Prevention, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Egidio
authors.initials: E
authors.lastname: Bottini
authors.affiliation: Department of Cardiac Surgery, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Chiariello
keywords: ACP1; CAD; Cardiovascular diseases; Genetic polymorphisms; LVEF; Phosphatases