title: Photodynamic therapy effective for the treatment of actinic keratosis and basal cell carcinoma in bullous pemphigoid patients.
abstract: Treating skin cancers and extensive actinic keratosis in patients with bullous pemphigoid (BP) can be challenging. Treatment options pose unique risks in these patients as surgical wounds can have delayed wound healing and photodynamic therapy (PDT) may exacerbate their blistering disease. We report the successful use of PDT to treat actinic keratosis and skin cancers in two patients with BP, both of whom had excellent response to PDT and tolerated treatment without any bullous disease flares. Carefully selected patients with skin cancers and stable, well controlled BP can be safely considered for treatment using PDT.
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, United States.
authors.forename: Theresa N
authors.initials: TN
authors.lastname: Canavan
authors.affiliation: Department of Dermatology, Emory University, United States.
authors.forename: Salma Faghri
authors.initials: SF
authors.lastname: de la Feld
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, United States.
authors.forename: Conway
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, United States; Department of Medicine, University of Central Florida, United States. Electronic address: nsderm@gmail.com.
authors.forename: Naveed
authors.initials: N
authors.lastname: Sami
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000622:Aminolevulinic Acid / Q000008:administration & dosage* / Q000627:therapeutic use*; D002280:Basal Cell Carcinoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D055623:Keratosis, Actinic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010391:Pemphigoid, Bullous / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: Actinic keratosis; Basal cell carcinoma; Pemphigoid; Photodynamic therapy