title: [Role of cannabinoid receptor 1-mediated synaptic plasticity in neuropathic pain and associated depression].
abstract: Neuropathic pain is a class of pain caused by an injury or diseases of the somatosensory system and characterized by spontaneous pain, allodynia, and hyperalgesia. It is well established that central sensitization is one of the key mechanisms underlying the development and maintenance of neuropathic pain. Cannabinoid receptor 1 (CB1R) of endocannabinoid system modulates synaptic transmission, regulates synaptic plasticity, inhibits central sensitization, and thus attenuates neuropathic pain. Recent studies have shown that activation of CB1R also involves in the relief of neuropathic pain-induced depression.
authors.affiliation: Department of Anethesiology, Jinling Hospital, Medical School of Nanjing University/Nanjing General Hospital of Nanjing Military Region, PLA, Nanjing 210002, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.affiliation: Department of Anethesiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Xingming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Anethesiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Guangfen
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Anethesiology, Zhongda Hospital, Medical School of Southeast University, Nanjing 210009, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Yang
mesh_terms: D003863:Depression / Q000517:prevention & control* / Q000523:psychology; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology; D009437:Neuralgia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D009473:Neuronal Plasticity / Q000502:physiology*; D043884:Receptor, Cannabinoid, CB1 / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: C571130:CNR1 protein, human; D043884:Receptor, Cannabinoid, CB1