title: Prognostic Significance of BMI-1 But Not MEL-18 Expression in Pulmonary Squamous Cell Carcinoma.
abstract: We investigated the possibility of BMI-1 and MEL-18 to predict survival in patients with pulmonary squamous cell carcinoma.
  
  
  
  One hundred and ninety-nine patients underwent surgery in our Institute between 1995 and 2005. We used immunohistochemical (IHC) analysis to determine the expressions of BMI-1 and MEL-18 and compared them with clinicopathological factors and survival.
  
  
  
  Forty-one of 199 cases (21%) were BMI-1-positive. No correlation was found between BMI-1 and MEL-18 expression by IHC and clinicopathological factors. Five-year overall survival in the BMI-1-positive group (66.8%), but not MEL-18, was significantly better than that in the negative group (45.5%, p=0.04). In multivariate analysis, positive BMI-1 was a better prognostic factor of overall survival (hazard ratio (HR)=0.561, 95% confidence interval (CI)=0.271-1.16, p=0.12).
  
  
  
  BMI-1 expression, but not MEL-18, is associated with a favorable prognosis and is a possible prognostic factor of pulmonary squamous cell carcinoma.
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Sosei
authors.initials: S
authors.lastname: Abe
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan yamashi1@fukuoka-u.ac.jp.
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Yamashita
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: S O
authors.initials: SO
authors.lastname: Miyahara
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Wakahara
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Leona
authors.initials: L
authors.lastname: Yamamoto
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Mori
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Imamura
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshida
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Waseda
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Hiratsuka
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shiraishi
authors.affiliation: Department of Pathology, Fukuoka University Hospital, Fukuoka, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nabeshima
authors.affiliation: Department of General Thoracic, Breast and Pediatric Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Iwasaki
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D048054:Mitogen-Activated Protein Kinase 7 / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C489348:PCGF2 protein, human; D063150:Polycomb Repressive Complex 1; C481581:MAPK7 protein, human; D048054:Mitogen-Activated Protein Kinase 7
keywords: BMI-1; Lung cancer; MEL-18; prognosis; squamous cell carcinoma