title: Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population.
abstract: BACKGROUND
  The arylamine N-acetyltransferase 2 (NAT2) is a key enzyme in the biotransformation of xenobiotics. NAT2 gene polymorphisms have been associated with the risk of isoniazid hepatotoxicity and these polymorphisms change among different populations.
  
  
  OBJECTIVE
  The objective of this study is to investigate NAT2 polymorphisms in order to predict the prevalence of NAT2 phenotype in an Algerian population.
  
  
  METHODS
  Genotyping of NAT2 was done using a PCR-RFLP method. Haplotype was analysed using the software package PHASE, version 2.0.
  
  
  RESULTS
  The major haplotypes were NAT2*5B (23.72%), NAT2*6 A (18.61%), NAT2*4 (14.60%) and NAT2*5 F (10%). The average of the expected slow acetylator phenotype was 53%.
  
  
  CONCLUSIONS
  Our results suggest that the high frequency of slow acetylator phenotype requires investigation into its possible association with ATDH.
authors.affiliation: a Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene , Alger ; Algérie.
authors.forename: Hiba
authors.initials: H
authors.lastname: Chelouti
authors.affiliation: a Département de Biologie Cellulaire et Moléculaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene , Alger ; Algérie.
authors.forename: Malika
authors.initials: M
authors.lastname: Khelil
mesh_terms: D000462:Algeria; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human
keywords: Arylamine N-acetyltransferase 2; SNP; tuberculosis