title: Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging.
abstract: Several mesoporous silica nanoparticle (MSN) contrast agents have been synthesized using a co-condensation method to incorporate two different Gd3+complexes at very high loadings (15.5-28.8 wt %). These MSN contrast agents, with an MCM-41 type pore structure, were characterized using a variety of methods including SEM and TEM, nitrogen adsorption measurements, thermogravimetric analysis (TGA), direct current plasma (DCP) spectroscopy, and powder X-ray diffraction (PXRD). The magnetic resonance (MR) relaxivities of these contrast agents were determined using a 3 T MR scanner. The r₁ relaxivities of these nanoparticles range from 4.1 to 8.4 mM-1s-1on a per Gd basis. Additionally, the MSN particles were functionalized with an organic fluorophore and cancer cell targeting peptide to allow for demonstration of both the optical and MR contrast enhancing capabilities in vitro.
authors.affiliation: Savannah River National Laboratory, Savannah River Site, Bldg. 773-A, Aiken, SC 29808, USA. kathryn.taylor-pashow@srnl.doe.gov.
authors.forename: Kathryn M L
authors.initials: KM
authors.lastname: Taylor-Pashow
authors.affiliation: Department of Chemistry, CB #3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. dellaroc@ad.unc.edu.
authors.forename: Joseph Della
authors.initials: JD
authors.lastname: Rocca
authors.affiliation: Department of Chemistry, CB #3290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. wlin@email.unc.edu.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lin
keywords: Gd3+ contrast agent; MRI contrast agent; mesoporous silica nanoparticle; multimodal imaging