title: Comparative Analysis of Structural Responses of Rat Subcutaneous Fat on the Implantation of Samples of Polymethyl Methacrylate with Hydrophobic and Hydrophilic Surface.
abstract: Morphological analysis of the subcutaneous fat was performed in rats after subcutaneous implantation of basic dental plastic materials with different hydrophobic and hydrophilic properties. It was shown that subcutaneous implantation of dental plastics with mostly hydrophobic surface and low biocompatibility induced destructive and inflammatory processes of various intensities, sometimes with allergic component; morphological signs of processes persisted for 6 weeks. Modification of basic plastics using glow-discharge plasma and enhancement of their hydrophilicity and biocompatibility significantly reduced the intensity of destructive and inflammatory processes and ensured more rapid (in 2 weeks) repair of the destroyed tissues with the formation of fibrous capsule around the implant.
authors.affiliation: I. M. Sechenov First Moscow State Medical University, the Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: E O
authors.initials: EO
authors.lastname: Kudasova
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: L F
authors.initials: LF
authors.lastname: Vlasova
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
authors.forename: D E
authors.initials: DE
authors.lastname: Semenov
authors.affiliation: Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia. pathol@inbox.ru.
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D057927:Hydrophobic and Hydrophilic Interactions; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D019904:Polymethyl Methacrylate / Q000633:toxicity*; D017208:Rats, Wistar; D050151:Subcutaneous Fat / Q000187:drug effects*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D019904:Polymethyl Methacrylate
keywords: biocompatibility; destructive and inflammatory processes; plastic implants; subcutaneous fat