title: Value of whole-body magnetic resonance imaging for screening multifocal osteonecrosis in patients with polymyositis/dermatomyositis.
abstract: OBJECTIVE
  To assess the value of coronal short-tau inversion recovery whole-body MRI (STIR-WBMRI) for screening osteonecrosis in patients with polymyositis (PM)/dermatomyositis (DM).
  
  
  METHODS
  The imaging and medical records of 129 patients with PM/DM who met the Bohan and Peter diagnostic criteria were retrospectively analyzed. STIR-WBMRI was performed in all patients. 18 patients had follow-up STIR-WBMRI. 12 patients underwent regional knee and/or hip MRI while 25 patients underwent radiography of the lower extremities.
  
  
  RESULTS
  STIR-WBMRI detected osteonecrosis in 15 (11.6%) patients. 38 joints were affected (mean, 2.5 per patient; range, 1-5 joints). Of the 38 joints affected by osteonecrosis, 33 had no clinical symptoms. Among the 12 patients who underwent regional MRI, STIR-WBMRI detected all 10 osteonecrotic sites seen on the regional MRI. The location, shape and size of the osteonecrotic lesions revealed on regional MRI were in accordance with those displayed on STIR-WBMRI. Of the 15 patients with osteonecrosis, 6 performed routine radiography of the affected joints and revealed no osteonecrotic lesions. Follow-up WBMRI detected new osteonecrosis in two patients whose first WBMRI revealed that there was no osteonecrosis in any skeleton.
  
  
  CONCLUSIONS
  In addition to displaying muscle inflammation, STIR-WBMRI can efficiently detect early multifocal osteonecrosis in the whole bodies of patients with PM/DM. Advances in knowledge: In patients with PM/DM, WBMRI which takes 12-15 min can display muscular involvement and detect early multisite osteonecrosis in the whole body at the same time. Osteonecrotic lesions revealed by WBMRI are in accordance with those displayed on regional WBMRI.
authors.affiliation: 1 Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Zhen-Guo
authors.affiliation: 1 Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Min-Xing
authors.affiliation: 1 Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xiao-Liang
authors.affiliation: 1 Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ran
authors.affiliation: 1 Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: He
authors.affiliation: 1 Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Gao
authors.initials: G
authors.lastname: Bao-Xiang
authors.affiliation: 2 Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Li-Guo
authors.affiliation: 3 Clinical Science, Philips Healthcare, Beijing, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Kai-Ning
authors.affiliation: 4 Clinical Science, Philips Healthcare, Hong Kong, China.
authors.forename: Queenie
authors.initials: Q
authors.lastname: Chan
authors.affiliation: 2 Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Guo-Chun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003882:Dermatomyositis / Q000150:complications; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D012189:Retrospective Studies; D051598:Whole Body Imaging; D055815:Young Adult