title: Atypical breast adenosquamous carcinoma following acute myeloid leukemia in a middle-aged woman: A case report.
abstract: Adenosquamous carcinoma of the breast is a rare cancer that develops as glands and tubules admixed with solid nests of squamous cells in a spindle cell background. Furthermore, its occurrence following AML is also rare. To the best of our knowledge, based on a review of the relevant literature, thus far there have not been any welldocumented cases. In the present case report, we report on a middle-aged woman with a 2year history of acute myeloid leukemia (AML) who was admitted to hospital due to a mass in the right breast, with concurrent cutaneous lesions on the breast. The clinical and pathological investigations resulted in the diagnosis of adenosquamous carcinoma of the breast. The patient underwent a modified radical mastectomy (MRM). Subsequently, the patient received chemotherapy, involved-field radiation therapy and target therapy. At 9 months after the final cycle of chemotherapy, and while she was on targeted therapy with trastuzumab (6 mg administered every 3 weeks), the patient presented with extensive dermatomal skin lesions. A biopsy report revealed metastatic lesions of invasive ductal carcinoma in the abdomen, so chemotherapy resumed with a course lasting for 6 cycles, with the identical treatments, but lacking trastuzumab.
authors.affiliation: Division of Hematology and Medical Oncology, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran; Division of Hematology and Medical Oncology, Department of Internal Medicine, Ali-Ebne-Abitaleb Hospital, Zahedan, Iran.
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Hashemi
authors.affiliation: Department of Internal Medicine, School of Medicine, Students' Scientific Research Center, Zahedan, Iran.
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Mahmoudi Shan
authors.affiliation: Department of Pathology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Jahantigh
authors.affiliation: Division of Hematology and Medical Oncology, Department of Medicine, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Allahyari
keywords: Iran; acute myeloid leukemia; adenosquamous carcinoma; breast cancer; metaplastic carcinoma