title: OPRM1 c.118A>G Polymorphism and Duration of Morphine Treatment Associated with Morphine Doses and Quality-of-Life in Palliative Cancer Pain Settings.
abstract: Despite increased attention on assessment and management, pain remains the most persistent symptom in patients with cancer, in particular in end-of-life settings, with detrimental impact on their quality-of-life (QOL). We conducted this study to evaluate the added value of determining some genetic and non-genetic factors to optimize cancer pain treatment. Eighty-nine patients were included in the study for the evaluation of palliative cancer pain management. The regression analysis showed that age,OPRM1single nucleotide polymorphism (SNP), as well as the duration of morphine treatment were significantly associated with morphine doses at 24 h (given by infusion pump;p= 0.043, 0.029, and <0.001, respectively). The mean doses of morphine decreased with age but increased with the duration of morphine treatment. In addition, patients with AG genotype c.118A>GOPRM1needed a higher dose of morphine than AA patients. Moreover, metastases,OPRM1SNP, age, and gender were significantly associated with the QOL in our population. In particular, AA patients forOPRM1SNP had significantly lower cognitive function than AG patients, a result not previously reported in the literature. These findings could help increase the effectiveness of morphine treatment and enhance the QOL of patients in regards to personalized medicine.
authors.affiliation: Laboratory of Pharmacology, Clinical Pharmacy and Quality Control of Drugs, Pôle Technologie- Santé (PTS), Faculty of Pharmacy, Saint-Joseph University, Beirut 1107 2180, Lebanon. aline.hajj@usj.edu.lb.
authors.forename: Aline
authors.initials: A
authors.lastname: Hajj
authors.affiliation: Laboratory of Pharmacology, Clinical Pharmacy and Quality Control of Drugs, Pôle Technologie- Santé (PTS), Faculty of Pharmacy, Saint-Joseph University, Beirut 1107 2180, Lebanon. lucine.halepian@hotmail.com.
authors.forename: Lucine
authors.initials: L
authors.lastname: Halepian
authors.affiliation: Department of Public Health, Faculty of Medicine, Saint-Joseph University, Beirut 1107 2180, Lebanon. pronada99@hotmail.com.|Department of Prosthodontics, Faculty of Dental Medicine, Saint-Joseph University, Beirut 1107 2180, Lebanon. pronada99@hotmail.com.|University of Auvergne, CROC-EA4847, Centre de Recherche en Odontologie Clinique, BP 10448, Clermont-Ferrand F-63000, France. pronada99@hotmail.com.
authors.forename: Nada El
authors.initials: NE
authors.lastname: Osta
authors.affiliation: Department of Hemato-Oncology, Hôtel-Dieu de France Hospital, Faculty of Medicine, Saint-Joseph University, Beirut 1107 2180, Lebanon. chahine_georges@hotmail.com.
authors.forename: Georges
authors.initials: G
authors.lastname: Chahine
authors.affiliation: Department of Hemato-Oncology, Hôtel-Dieu de France Hospital, Faculty of Medicine, Saint-Joseph University, Beirut 1107 2180, Lebanon. joseph.kattan@usj.edu.lb.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kattan
authors.affiliation: Laboratory of Pharmacology, Clinical Pharmacy and Quality Control of Drugs, Pôle Technologie- Santé (PTS), Faculty of Pharmacy, Saint-Joseph University, Beirut 1107 2180, Lebanon. lydia.khabbaz@usj.edu.lb.
authors.forename: Lydia
authors.initials: L
authors.lastname: Rabbaa Khabbaz
mesh_terms: D000367:Age Factors; D000368:Aged; D000483:Alleles; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D044466:Asian People / Q000235:genetics; D000072716:Cancer Pain / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007861:Lebanon; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D009362:Neoplasm Metastasis; D010166:Palliative Care; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life; D017450:Receptors, Opioid, mu / Q000235:genetics*; D012737:Sex Factors
chemical_list: D000701:Analgesics, Opioid; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu; D009020:Morphine
keywords: ABCB1; COMT; OPRM1; cancer; morphine; pain; pharmacogenetics; polymorphism; quality-of-life