title: Significant Decreasing Incidence of Encapsulating Peritoneal Sclerosis in the Dutch Population of Peritoneal Dialysis Patients.
abstract: The Dutch Encapsulating Peritoneal Sclerosis (EPS) Registry was started in 2009. Cases were identified by contacting all Dutch nephrologists twice yearly. The predefined criteria for EPS allowed for inclusion of patients with diagnosed and suspected EPS. Cases registered between January 2009 and January 2015 were analyzed with follow-up until September 2015. Fifty-three EPS cases were identified, of which 28.3% were post-transplantation EPS cases. Fourteen patients were initially categorized as suspected EPS, of whom 13 developed EPS. A remarkable 6-fold decrease in the yearly incidence of EPS was observed, from 0.85% in 2009 to 0.14% in 2014. This decrease could not be explained by a decrease in the number of PD patients or average duration of PD treatment in this period. Two-year survival of EPS patients was 52%. The use of tamoxifen and surgical interventions increased significantly over the years. Tamoxifen-treated cases showed a trend to better patient survival and post-transplantation EPS had a significantly favorable outcome. In conclusion, the incidence of EPS has declined significantly in the Netherlands from 2009 to 2014.
authors.affiliation: Erasmus Medical Center, Department of Nephrology & Transplantation, Erasmus Medical Center, Rotterdam, Netherlands m.g.h.betjes@erasmusmc.nl.
authors.forename: Michiel G H
authors.initials: MG
authors.lastname: Betjes
authors.affiliation: Erasmus Medical Center, Department of Nephrology & Transplantation, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Sayed M
authors.initials: SM
authors.lastname: Habib
authors.affiliation: Dutch Renal Registry, Nefrovisie, Utrecht, Netherlands.
authors.forename: Els W
authors.initials: EW
authors.lastname: Boeschoten
authors.affiliation: Dutch Renal Registry, Nefrovisie, Utrecht, Netherlands.
authors.forename: Aline C
authors.initials: AC
authors.lastname: Hemke
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Academic Medical Center, Amsterdam, Netherlands.
authors.forename: Dick G
authors.initials: DG
authors.lastname: Struijk
authors.affiliation: Dialysis Center Groningen, Groningen, Netherlands.
authors.forename: Ralph
authors.initials: R
authors.lastname: Westerhuis
authors.affiliation: Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Alferso C
authors.initials: AC
authors.lastname: Abrahams
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Albert Schweitzer Hospital, Dordrecht, Netherlands.
authors.forename: Mario R
authors.initials: MR
authors.lastname: Korte
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000379:methods / Q000706:statistics & numerical data; D056627:Peritoneal Fibrosis / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D016016:Proportional Hazards Models; D058996:Quality Improvement; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution
keywords: Encapsulating peritoneal sclerosis; peritoneal dialysis; registry; tamoxifen