title: Capparis spinosa L.aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice.
abstract: OBJECTIVE
  As the aqueous extract ofCapparis spinosa(CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice.
  
  
  METHODS
  Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.
  
  
  RESULTS
  Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-3H glucose demonstrated the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p<0.001). The euglycemic hyperinsulinemic clamp technique demonstrated that CS treatment improves insulin sensitivity in peripheral tissues.
  
  
  CONCLUSIONS
  We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice.
authors.affiliation: Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Eddouks
authors.affiliation: Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Lemhadri
authors.affiliation: Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
authors.forename: Morad
authors.initials: M
authors.lastname: Hebi
authors.affiliation: Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
authors.forename: Ahmed
authors.initials: A
authors.lastname: El Hidani
authors.affiliation: Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco; ISPITS Rabat, Avenue Hassan II Km 4,5 Route de Casa, Rabat Maroc.
authors.forename: Naoufel Ali
authors.initials: NA
authors.lastname: Zeggwagh
authors.affiliation: Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
authors.forename: Bachir
authors.initials: B
authors.lastname: El Bouhali
authors.affiliation: Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
authors.forename: Lhoussaine
authors.initials: L
authors.lastname: Hajji
authors.affiliation: UMR 5018 CNRS-UPS and IFR 31, Rangueil Hospital, L1 Bldg, BP 84225 Toulouse 31432 Cedex 4, France.
authors.forename: Remy
authors.initials: R
authors.lastname: Burcelin
keywords: Diabetes; Insulin sensitivity; Mice; Streptozotocin