title: Estrogen receptor-alpha gene XbaI A > G polymorphism influences short-term cognitive decline in healthy oldest-old individuals.
abstract: METHODS
  The individuals were categorized in two groups according to the presence or absence of cognitive decline. Cognitive data were related to genetic information.
  
  
  RESULTS
  The XbaI -351 AA genotype was more common among cognitive decliners, while -351G allele carriers showed cognitive stability or improvement.
  
  
  CONCLUSIONS
  These results suggest that ESR-1 could be associated with one-year cognitive decline in healthy oldest-old individuals, since the estrogen pathway may be involved with neuroprotection, even in healthy brain aging.
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte MG, Brasil.
authors.forename: Amanda Caroline Silva
authors.initials: AC
authors.lastname: Chaves
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte MG, Brasil.
authors.forename: Vanessa Gomes
authors.initials: VG
authors.lastname: Fraga
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Clínica Médica, Belo Horizonte MG,Brasil.
authors.forename: Henrique Cerqueira
authors.initials: HC
authors.lastname: Guimarães
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Clínica Médica, Belo Horizonte MG,Brasil.
authors.forename: Antonio Lucio
authors.initials: AL
authors.lastname: Teixeira
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Clínica Médica, Belo Horizonte MG,Brasil.
authors.forename: Maira Tonidandel
authors.initials: MT
authors.lastname: Barbosa
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte MG, Brasil.
authors.forename: Maria das Graças
authors.initials: MD
authors.lastname: Carvalho
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte MG, Brasil.
authors.forename: Ana Paula Lucas
authors.initials: AP
authors.lastname: Mota
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte MG, Brasil.
authors.forename: Ieda de Fátima Oliveira
authors.initials: IF
authors.lastname: Silva
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Clínica Médica, Belo Horizonte MG,Brasil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Caramelli
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte MG, Brasil.
authors.forename: Karina Braga
authors.initials: KB
authors.lastname: Gomes
authors.affiliation: Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte MG, Brasil.
authors.forename: Patrícia Nessralla
authors.initials: PN
authors.lastname: Alpoim
mesh_terms: D000368:Aged; D003071:Cognition; D003072:Cognition Disorders / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies
chemical_list: D047628:Estrogen Receptor alpha