title: Anticancer activity of a series of copper(II) complexes with tripodal ligands.
abstract: A series of copper(II) complexes with tripodal polypyridylamine ligands (derived from the parent ligand tris(2-pyridylmethyl)amine, tmpa) has been synthesized. Crystallographic characterization was possible for all complexes obtained. The copper(II) chloride complexes were investigated for their in vitro anticancer potential using human tumor cell lines containing examples of cervical, colon, ovarian cancers and melanoma. Some compounds showed a similar activity compared to that of cisplatin, however no systematic behavior could be observed.
authors.affiliation: Institut für Anorganische und Analytische Chemie, Justus-Liebig-Universität Gießen, Heinrich-Buff-Ring 58, 35392 Gießen, Germany.
authors.forename: Melanie
authors.initials: M
authors.lastname: Jopp
authors.affiliation: Institut für Anorganische und Analytische Chemie, Justus-Liebig-Universität Gießen, Heinrich-Buff-Ring 58, 35392 Gießen, Germany.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Becker
authors.affiliation: Institut für Anorganische und Analytische Chemie, Justus-Liebig-Universität Gießen, Heinrich-Buff-Ring 58, 35392 Gießen, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Becker
authors.affiliation: Institut für Anorganische und Analytische Chemie, Justus-Liebig-Universität Gießen, Heinrich-Buff-Ring 58, 35392 Gießen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Miska
authors.affiliation: Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, 35131 Padova, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Gandin
authors.affiliation: Dipartimento di Scienze del Farmaco, Università di Padova, Via Marzolo 5, 35131 Padova, Italy. Electronic address: cristina.marzano@unipd.it.
authors.forename: Cristina
authors.initials: C
authors.lastname: Marzano
authors.affiliation: Institut für Anorganische und Analytische Chemie, Justus-Liebig-Universität Gießen, Heinrich-Buff-Ring 58, 35392 Gießen, Germany. Electronic address: siegfried.schindler@anorg.chemie.uni-giessen.de.
authors.forename: Siegfried
authors.initials: S
authors.lastname: Schindler
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D011725:Pyridines
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D011725:Pyridines; C431843:tris(2-pyridylmethyl)amine; D003300:Copper; D002945:Cisplatin
keywords: Amine donor atoms; Anti tumor; Copper complexes; Cytotoxicity; Tripodal ligands