title: 90-kDa N-domain angiotensin I-converting enzyme (ACE): possible marker for hypertension in a renal transplant model.
abstract: BACKGROUND
  Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition.
  
  
  OBJECTIVE
  The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE.
  
  
  METHODS
  To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham.
  
  
  CONCLUSIONS
  Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery.
  
  
  CONCLUSIONS
  Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Cleber A
authors.initials: CA
authors.lastname: Leite
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Nádia Sc
authors.initials: NS
authors.lastname: Bertoncello
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Ingrid Km
authors.initials: IK
authors.lastname: Watanabe
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Fernanda B
authors.initials: FB
authors.lastname: Fernandes
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Maria Claudina C
authors.initials: MC
authors.lastname: Andrade
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Fernanda A
authors.initials: FA
authors.lastname: Ronchi
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Danielle Y
authors.initials: DY
authors.lastname: Arita
authors.affiliation: Universidade Estadual de Campinas, Brazil.
authors.forename: Fernanda K
authors.initials: FK
authors.lastname: Marcondes
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Tatiana S
authors.initials: TS
authors.lastname: Cunha
authors.affiliation: Universidade Federal de São Paulo, Brazil.
authors.forename: Dulce E
authors.initials: DE
authors.lastname: Casarini
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D004195:Disease Models, Animal; D006973:Hypertension / Q000201:enzymology* / Q000209:etiology*; D016030:Kidney Transplantation; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000032:analysis*; D011183:Postoperative Complications / Q000201:enzymology* / Q000209:etiology*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D007703:Peptidyl-Dipeptidase A