title: Systemic angiopoietin-1/2 dysregulation following cardiopulmonary bypass in adults.
abstract: OBJECTIVE
  Vascular leakage following cardiopulmonary bypass contributes to morbidity. Angiopoietin-1 and -2 are biomarkers of endothelial dysfunction. Our aim was to characterize Ang-1 and -2 association with clinical characteristics and outcomes.
  
  
  METHODS
  Observational cohort study measuring Ang-1/-2 with a panel of cytokines in adults undergoing cardiopulmonary bypass.
  
  
  RESULTS
  Ang-2 levels increased immediately postop whereas Ang-1 levels decreased over time. No significant correlation was found with other inflammatory mediators. High correlation was found between the hospital length of stay and Ang-2 increase at 24 h (rho = 0.590; p < 0.0001). The predictors of Ang-2 increase were female gender, cross clamp time, transfusion of blood and absence of angiotensin-converting enzyme inhibitor as a pre-op medication.
  
  
  CONCLUSIONS
  Angiopoietins can detect vascular leakage early and could impact patient's management to decrease length of stay after cardiac surgery.
authors.affiliation: Centre de Recherche de l'Hôpital du Sacré-Coeur, University of Montreal, 5400 Boulevard Gouin Ouest, Montréal, QC H4J 1C5, Canada; Centre de Recherche de l'Hôpital du Sacré-Coeur, University of Montreal, 5400 Boulevard Gouin Ouest, Montréal, QC H4J 1C5, Canada.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Charbonney
authors.affiliation: Interdepartmental Division of Critical Care, University of Toronto, University Health Network, 399 Bathurst St, Toronto, ON M5T 2S8, Canada; Interdepartmental Division of Critical Care, University of Toronto, University Health Network, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Wilcox
authors.affiliation: Keenan Research Centre of Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON M5B 1W8, Canada; Keenan Research Centre of Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON M5B 1W8, Canada.
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Department of Anesthesia, University of Toronto 12th Floor, 123 Edward Street, Toronto, ON M5G 1E2, Canada; Department of Anesthesia, University of Toronto 12th Floor, 123 Edward Street, Toronto, ON M5G 1E2, Canada.
authors.forename: Pablo Perez
authors.initials: PP
authors.lastname: d'Empaire
authors.affiliation: Department of Pulmonary, Allergy, & Critical Care, Respiratory Institute, Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Department of Pulmonary, Allergy, & Critical Care, Respiratory Institute, Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Duggal
authors.affiliation: Interdepartmental Division of Critical Care, University of Toronto, Trauma, Emergency & Critical Care Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada; Interdepartmental Division of Critical Care, University of Toronto, Trauma, Emergency & Critical Care Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
authors.forename: Gordon D
authors.initials: GD
authors.lastname: Rubenfeld
authors.affiliation: Department of Medicine, University of Washington, 1959 NE Pacific St. Box 356420, Seattle, WA 98195, USA; Department of Medicine, University of Washington, 1959 NE Pacific St. Box 356420, Seattle, WA 98195, USA.
authors.forename: Conrad
authors.initials: C
authors.lastname: Liles
authors.affiliation: Interdepartmental Division of Critical Care, University of Toronto, St. Michael's Hospital-Keenan Research Centre of Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON M5B 1W8, Canada; Interdepartmental Division of Critical Care, University of Toronto, St. Michael's Hospital-Keenan Research Centre of Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON M5B 1W8, Canada.
authors.forename: Claudia Dos
authors.initials: CD
authors.lastname: Santos
keywords: angiopoietin; biomarker; cardiac surgery; cardiopulmonary bypass; length of stay; vascular leakage; vascular permeability