title: Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform.
abstract: The generation of a strong antibody response to target antigens is a major goal for vaccine development. Here we describe the display of the human immunodeficiency virus (HIV) envelope spike protein (Env) on a virus-like scaffold provided by the lambda phage capsid. Phage vectors, in general, have advantages over mammalian virus vectors due to their genetic tractability, inexpensive production, suitability for scale-up, as well as their physical stability, making them an attractive vaccine platform.
authors.affiliation: Saint John Fisher College, 3690 East Ave., Rochester, NY, 14618, USA. jmattiacio@sjfc.edu.
authors.forename: Jonelle L
authors.initials: JL
authors.lastname: Mattiacio
authors.affiliation: Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA.
authors.forename: Matt
authors.initials: M
authors.lastname: Brewer
authors.affiliation: Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Dewhurst
mesh_terms: D016915:AIDS Vaccines; D010582:Bacteriophage lambda / Q000235:genetics*; D005822:Genetic Vectors / Q000235:genetics; D057809:HEK293 Cells; D006801:Humans; D058425:Vaccines, Virus-Like Particle / Q000235:genetics* / Q000276:immunology; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics* / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D058425:Vaccines, Virus-Like Particle; D054299:env Gene Products, Human Immunodeficiency Virus
keywords: Bacteriophage lambda; Envelope protein; Virus-like particle