title: Intraductal Carcinoma of the Prostate: A Risk for Rapid Recurrence.
abstract: Intraductal carcinoma of the prostate (IDC-P), recently defined by the World Health Organization in 2016, is a distinct histologic entity associated with an aggressive clinical course, including increased risk of biochemical recurrence, metastasis, and mortality. Differential diagnosis includes intraductal spread of urothelial carcinoma, prostatic ductal carcinoma, and high-grade prostatic intraepithelial neoplasia. BRCA mutations are associated with an increased risk of IDC-P. The presence of IDC-P on initial biopsy or radical prostatectomy should trigger aggressive treatment and should be considered a contraindication to active surveillance, regardless of tumor volume.
authors.affiliation: Department of Urology, Weill Cornell Medical College, New York, NY.
authors.forename: Brian F
authors.initials: BF
authors.lastname: Dinerman
authors.affiliation: Department of Urology, Weill Cornell Medical College, New York, NY.
authors.forename: Adrien N
authors.initials: AN
authors.lastname: Bernstein
authors.affiliation: Department of Urology, Weill Cornell Medical College, New York, NY; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY.
authors.forename: Francesca
authors.initials: F
authors.lastname: Khani
authors.affiliation: Department of Urology, Weill Cornell Medical College, New York, NY. Electronic address: jch9011@med.cornell.edu.
authors.forename: Jim C
authors.initials: JC
authors.lastname: Hu
mesh_terms: D044584:Carcinoma, Ductal / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*