title: Risk of Malignancy in Thyroid Incidentaloma is Not Increased in Overweight or Obese Patients, but in Young Patients.
abstract: Thyroid incidentaloma is defined as an unsuspected, asymptomatic thyroid lesion that is discovered on an imaging study or during an operation unrelated to the thyroid gland. We aim to evaluate the relationship between overweight or obese and risk of malignancy in patients with thyroid incidentaloma detected by F18-flurodeoxyglucose positron emission tomography/computed tomography and factors to predict risk of malignancy in thyroid incidentaloma. From January 2010 to December 2013, a total of 238 patients were eligible for this study. Using the Bethesda system for reporting thyroid cytopathology, categories I-III were defined as a nonmalignancy and categories V-VI were defined as a malignancy. When patients with body mass index (BMI) of less than 23 and 23 or more were divided into two groups of normal and overweight or obese, risk of malignancy of thyroid incidentaloma was not significantly different between two groups (P = 0.1812). In logistic regression analysis, age was the only variable that showed a significant association with malignancy of thyroid incidentaloma (odds ratio 0.9608, P = 0.0021). However, none of sex, height, weight, and BMI was predictor of malignancy of thyroid incidentaloma. We demonstrated that being overweight or obese did not increase rate of malignancy in patients with thyroid incidentaloma.
authors.affiliation: a Department of Nuclear Medicine and Biomedical Research Institute , Pusan National University Hospital , Busan , Korea.
authors.forename: Kyoungjune
authors.initials: K
authors.lastname: Pak
authors.affiliation: a Department of Nuclear Medicine and Biomedical Research Institute , Pusan National University Hospital , Busan , Korea.
authors.forename: Seunghyeon
authors.initials: S
authors.lastname: Shin
authors.affiliation: a Department of Nuclear Medicine and Biomedical Research Institute , Pusan National University Hospital , Busan , Korea.
authors.forename: So Jung
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: a Department of Nuclear Medicine and Biomedical Research Institute , Pusan National University Hospital , Busan , Korea.
authors.forename: Keunyoung
authors.initials: K
authors.lastname: Kim
authors.affiliation: b Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology , Pusan National University Yangsan Hospital , Yangsan , Korea.
authors.forename: Bum Soo
authors.initials: BS
authors.lastname: Kim
authors.affiliation: b Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology , Pusan National University Yangsan Hospital , Yangsan , Korea.
authors.forename: Seong Jang
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: c Department of Internal Medicine and Biomedical Research Institute , Pusan National University Hospital , Busan , Korea.
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Jeon
authors.affiliation: c Department of Internal Medicine and Biomedical Research Institute , Pusan National University Hospital , Busan , Korea.
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kim
authors.affiliation: c Department of Internal Medicine and Biomedical Research Institute , Pusan National University Hospital , Busan , Korea.
authors.forename: Bo Hyun
authors.initials: BH
authors.lastname: Kim
authors.affiliation: a Department of Nuclear Medicine and Biomedical Research Institute , Pusan National University Hospital , Busan , Korea.
authors.forename: In-Joo
authors.initials: IJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18