title: Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress.
abstract: Resilience has been conceptualized in part as a dynamic process that includes the ability to adapt to stressful conditions. As such it encompasses the extent to which neural plasticity may be promoted. The current study examined metaplasticity by referring to the "plasticity of synaptic plasticity" in a neural circuit composed of the basolateral amygdala (BLA) and the nucleus accumbens (NAcc), using behavioural stress controllability with or without preceding stimulation of the dorsal periaqueductal gray (i.e. dPAG priming). A tendency for increased plasticity in the controllable versus the uncontrollable group was found in both the BLA and NAcc. dPAG priming suppressed NAcc LTP in all groups, but it suppressed BLA LTP only in the uncontrollable group, demonstrating dissociation between either controllable and uncontrollable groups or the NAcc and BLA. Thus, metaplasticity in the dPAG-BLA-NAcc circuit regulated differentially by controllable or uncontrollable stress may underlie stress coping, and thus contribute to stress-related psychopathologies.
authors.affiliation: Department of Psychology, University of Haifa, Haifa, Israel. horovitz.omer@gmail.com.
authors.forename: Omer
authors.initials: O
authors.lastname: Horovitz
authors.affiliation: Sagol Department of Neurobiology, University of Haifa, Haifa, Israel.
authors.forename: Alon
authors.initials: A
authors.lastname: Richter-Levin
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, 650223, China.|University of the Chinese Academy of Sciences, Beijing, 100049, China.|CAS Center for Excellence in Brain Science, 320 Yue Yang Road, Shanghai, 200031, China.
authors.forename: Lin
authors.identifier: 0000-0002-2710-3507
authors.initials: L
authors.lastname: Xu
authors.affiliation: The Institute for the Study of Affective Neuroscience (ISAN), Haifa, Israel.|Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, 650223, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Jing
authors.affiliation: Department of Psychology, University of Haifa, Haifa, Israel.|The Institute for the Study of Affective Neuroscience (ISAN), Haifa, Israel.|Sagol Department of Neurobiology, University of Haifa, Haifa, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Richter-Levin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning; D066272:Basolateral Nuclear Complex / Q000502:physiology*; D004558:Electric Stimulation; D055724:Electrophysiological Phenomena; D008297:Male; D009473:Neuronal Plasticity; D009714:Nucleus Accumbens / Q000502:physiology*; D010487:Periaqueductal Gray / Q000502:physiology*; D011597:Psychomotor Performance; D051381:Rats; D013315:Stress, Psychological