title: The regulation and role of carbohydrate response element-binding protein in metabolic homeostasis and disease.
abstract: The transcription factor carbohydrate response element-binding protein (ChREBP) is a member of the basic helix-loop-helix leucine zipper transcription factor family. Under high-glucose conditions, it has a role in regulating the expression of key genes involved in various pathways, including glycolysis, gluconeogenesis and lipogenesis. It does this by forming a tetrameric complex made up of two ChREBP/Mlx heterodimers, which enables it to bind to the carbohydrate response element (ChoRE) in the promoter region of its target genes to regulate transcription. Because ChREBP plays a key role in glucose signalling and metabolism, and aberrations in glucose homeostasis are often present in metabolic diseases, this transcription factor presents itself as an enticing target with respect to further understanding metabolic disease mechanisms and potentially uncovering new therapeutic targets.
authors.affiliation: Department of Physiology, Monash University, Clayton, VIC, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Jois
authors.affiliation: Department of Physiology, Monash University, Clayton, VIC, Australia.|Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.|Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
authors.forename: M W
authors.identifier: 0000-0002-3329-0919
authors.initials: MW
authors.lastname: Sleeman
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D005234:Fatty Liver / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism*
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C116385:MLXIPL protein, human; D005947:Glucose
keywords: carbohydrate response element-binding protein; glucose homeostasis; hepatic steatosis; insulin resistance