title: TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization.
abstract: Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema. Transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively) are non-selective cation channels known to specifically participate in pain and CNI. Both TRPV1 and TRPA1 are co-expressed in a large subset of sensory nerves, where they integrate numerous noxious stimuli. It is now clear that the expression of both channels also extends far beyond the sensory nerves in the skin, occuring also in keratinocytes, mast cells, dendritic cells, and endothelial cells. In these non-neuronal cells, TRPV1 and TRPA1 also act as nociceptive sensors and potentiate the inflammatory process. This review discusses the role of TRPV1 and TRPA1 in the modulation of inflammatory genes that leads to or maintains CNI in sensory neurons and non-neuronal skin cells. In addition, this review provides a summary of current research on the intracellular sensitization pathways of both TRP channels by other endogenous inflammatory mediators that promote the self-maintenance of CNI.
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.|Uriage Dermatological Laboratories, 92400, Courbevoie, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Gouin
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.
authors.forename: Killian
authors.initials: K
authors.lastname: L'Herondelle
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lebonvallet
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Le Gall-Ianotto
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sakka
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Buhé
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Plée-Gautier
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Carré
authors.affiliation: Uriage Dermatological Laboratories, 92400, Courbevoie, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Lefeuvre
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France. laurent.misery@chu-brest.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Misery
authors.affiliation: Laboratory on Interaction Neurons-Keratinocytes (LINK), University of Western Brittany, 29200, Brest, France.
authors.forename: Raphaele
authors.initials: R
authors.lastname: Le Garrec
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology; D003872:Dermatitis / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology; D011984:Sensory Receptor Cells / Q000378:metabolism* / Q000473:pathology; D000074025:TRPA1 Cation Channel / Q000096:biosynthesis*; D050916:TRPV Cation Channels / Q000096:biosynthesis*
chemical_list: D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human
keywords: inflammatory gene regulation; neurogenic skin inflammation; pruritus; sensory nerve