title: Evaluation of the separation and purification of227Th from its decay progeny by anion exchange and extraction chromatography.
abstract: Thorium-227 is currently undergoing evaluation as a potential radionuclide for targeted cancer therapy, and as such a high chemical purity of the material is required. To establish a reliable procedure for radiochemical isolation of227Th from the parent227Ac and decay progeny, which includes the radiotherapeutic223Ra, the performance of three different separation schemes based on ion-exchange and extraction chromatography have been evaluated. The results suggest that both ion exchange and extraction chromatographic techniques can be successfully used for the separation of227Th from its decay progeny, however extraction chromatographic resins demonstrate favourable performance in terms of Th recovery and purification from radionuclide impurities.
authors.affiliation: National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW, United Kingdom. Electronic address: peter.ivanov@npl.co.uk.
authors.forename: P I
authors.initials: PI
authors.lastname: Ivanov
authors.affiliation: National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW, United Kingdom.
authors.forename: S M
authors.initials: SM
authors.lastname: Collins
authors.affiliation: National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW, United Kingdom; Chemistry Department, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom.
authors.forename: E M
authors.initials: EM
authors.lastname: van Es
authors.affiliation: National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: García-Miranda
authors.affiliation: National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW, United Kingdom.
authors.forename: S M
authors.initials: SM
authors.lastname: Jerome
authors.affiliation: National Physical Laboratory, Hampton Road, Teddington, Middlesex TW11 0LW, United Kingdom.
authors.forename: B C
authors.initials: BC
authors.lastname: Russell
mesh_terms: D000186:Actinium / Q000302:isolation & purification; D000512:Alpha Particles; D002852:Chromatography, Ion Exchange / Q000379:methods*; D005857:Germanium; D006801:Humans; D007475:Ion Exchange Resins; D019275:Radiopharmaceuticals / Q000302:isolation & purification*; D017687:Radon Daughters / Q000302:isolation & purification; D013051:Spectrometry, Gamma; D013054:Spectrophotometry, Atomic; D013910:Thorium / Q000302:isolation & purification*
chemical_list: C000617035:Actinium-227; D007475:Ion Exchange Resins; D019275:Radiopharmaceuticals; D017687:Radon Daughters; C000615160:Thorium-227; D005857:Germanium; D013910:Thorium; D000186:Actinium
keywords: (227)Th; Extraction chromatography; Ion-exchange; Radiochemical separation; Radiopharmaceuticals