title: Genome evolution in yeast reveals connections between rare mutations in human cancers.
abstract: Cancer cells are riddled with mutations. Less than one percent of these are thought to be mutations that drive cancer phenotypes. However, a recent study conducted on the yeast knockout collections by Tenget al.[Mol. Cell (2013) 52: 485-494] provides hard evidence that single gene deletions/mutations in most non-essential genes can drive the selection for cancer-like mutations.
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu Province 215123, PRChina. ; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205 USA.
authors.forename: Xinchen
authors.initials: X
authors.lastname: Teng
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205 USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Hardwick
keywords: cancer progression; genome evolution; secondary mutations; yeast knockouts