title: Meta-analysis of the effectiveness of psychological and medical treatments for binge-eating disorder (MetaBED): study protocol.
abstract: Binge-eating disorder (BED) was included as its own diagnostic entity in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). An increasing number of treatment studies have been published, but an up-to-date comprehensive meta-analysis on diverse treatment approaches for BED is lacking. In an updated and extension of a previous meta-analysis, the goals of this study are to assess the short-term and long-term effectiveness of psychological and medical treatments for BED.
  
  
  
  We will search bibliographic databases and study registries, including manual searches for studies published before January 2016. The search strategy will include terms relating to binge eating and diverse forms of psychological and medical interventions. Language will be restricted to English. The studies included will be treatment studies, that is, randomised-controlled trials, and non-randomised and non-controlled studies, for individuals with BED (DSM-IV or DSM-5), and studies that provided a pre-treatment and at least one post-treatment or follow-up assessment of binge eating. The primary outcomes will be the number of binge-eating episodes, abstinence from binge eating and diagnosis of BED at post-treatment and/or follow-up(s), and changes from pre-treatment to post-treatment and/or follow-up(s). Likewise, as secondary outcomes, eating disorder and general psychopathology, quality of life, and body weight will be analysed and adverse events and treatment drop-out will be examined. Study search, selection and data extraction, including risk of bias assessment, will be independently performed by 2 reviewers and consensus will be sought. Moderator analyses will be conducted, and equity aspects will be considered. Sensitivity analyses will be conducted to determine the robustness of the results.
  
  
  
  Ethical approval is not required for this meta-analysis. Published in a peer-reviewed journal and disseminated electronically and in print, this meta-analysis will form the basis of the renewal of the German evidence-based S3 Guidelines of Diagnosis and Treatment of Eating Disorders, specifically BED.
  
  
  
  CRD42016043604.
authors.affiliation: Department of Medical Psychology and Medical Sociology, Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Hilbert
authors.affiliation: Clinical Trial Center Leipzig, University of Leipzig, Leipzig, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Petroff
authors.affiliation: Department of Psychosomatic Medicine, LWL-University Clinic, Ruhr-University Bochum, Bochum, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Herpertz
authors.affiliation: Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
authors.forename: Anette
authors.initials: A
authors.lastname: Kersting
authors.affiliation: Department of Clinical Psychology, Institute of Experimental Psychology, University of Düsseldorf, Düsseldorf, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Pietrowsky
authors.affiliation: Department of Psychology, University of Freiburg, Freiburg, Germany.
authors.forename: Brunna
authors.initials: B
authors.lastname: Tuschen-Caffier
authors.affiliation: Department of Clinical Psychology and Psychotherapy, Institute of Psychology, University of Osnabrück, Osnabrück, Germany.
authors.forename: Silja
authors.initials: S
authors.lastname: Vocks
authors.affiliation: Department of Medical Psychology and Medical Sociology, Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.
authors.forename: Ricarda
authors.initials: R
authors.lastname: Schmidt
mesh_terms: D050110:Bariatric Surgery / Q000379:methods; D056912:Binge-Eating Disorder / Q000628:therapy*; D002986:Clinical Trials as Topic; D003625:Data Collection / Q000379:methods; D006801:Humans; D033181:Information Dissemination / Q000379:methods; D011613:Psychotherapy / Q000379:methods; D015983:Selection Bias; D012648:Self Care; D016896:Treatment Outcome; D015431:Weight Loss; D015201:Meta-Analysis as Topic
keywords: bariatric surgery; binge-eating disorder; meta-analysis; pharmacotherapy; psychotherapy; treatment