title: Iron Oxide Nanocrystals for Magnetic Hyperthermia Applications.
abstract: Magnetic nanocrystals have been investigated extensively in the past several years for several potential applications, such as information technology, MRI contrast agents, and for drug conjugation and delivery. A specific property of interest in biomedicine is magnetic hyperthermia-an increase in temperature resulting from the thermal energy released by magnetic nanocrystals in an external alternating magnetic field. Iron oxide nanocrystals of various sizes and morphologies were synthesized and tested for specific losses (heating power) using frequencies of 111.1 kHz and 629.2 kHz, and corresponding magnetic field strengths of 9 and 25 mT. Polymorphous nanocrystals as well as spherical nanocrystals and nanowires in paramagnetic to ferromagnetic size range exhibited good heating power. A remarkable 30 °C temperature increase was observed in a nanowire sample at 111 kHz and magnetic field of 25 mT (19.6 kA/m), which is very close to the typical values of 100 kHz and 20 mT used in medical treatments.
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. leishyne@unm.edu.
authors.forename: Leisha M
authors.initials: LM
authors.lastname: Armijo
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. ybrandt@salud.unm.edu.
authors.forename: Yekaterina I
authors.initials: YI
authors.lastname: Brandt
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. dmathew@chtm.unm.edu.
authors.forename: Dimple
authors.initials: D
authors.lastname: Mathew
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. surabhi.iitd@gmail.com.
authors.forename: Surabhi
authors.initials: S
authors.lastname: Yadav
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. salomon@unm.edu.
authors.forename: Salomon
authors.initials: S
authors.lastname: Maestas
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. arivera@chtm.unm.edu.
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Rivera
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. ncook93@unm.edu.
authors.forename: Nathaniel C
authors.initials: NC
authors.lastname: Cook
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. nwithers@chtm.unm.edu.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Withers
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. gen@chtm.unm.edu.
authors.forename: Gennady A
authors.initials: GA
authors.lastname: Smolyakov
authors.affiliation: Department of Biochemistry and Molecular Biology, Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA. nadolphi@salud.unm.edu.
authors.forename: Natalie L
authors.initials: NL
authors.lastname: Adolphi
authors.affiliation: Sandia National Laboratories, Nanomaterials Sciences, P.O. Box 5800, MS 1415, Albuquerque, NM 87185, USA. tmonson@sandia.gov.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Monson
authors.affiliation: Center for Integrated Nanotechnologies, Sandia National Laboratories, 1000 Eubank SE, Albuquerque, NM 87123, USA. dlhuber@sandia.gov.
authors.forename: Dale L
authors.initials: DL
authors.lastname: Huber
authors.affiliation: College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA. hsmyth@mail.utexas.edu.
authors.forename: Hugh D C
authors.initials: HD
authors.lastname: Smyth
authors.affiliation: Center for High Technology Materials, 1313 Goddard SE, University of New Mexico, Albuquerque, NM 87106, USA. osinski@chtm.unm.edu.
authors.forename: Marek
authors.initials: M
authors.lastname: Osiński
keywords: ferrofluid; hyperthermia; iron oxide nanocrystals; thermotherapy