title: Comparison of anti-inflammatory and analgesic effects of Ginger powder and Ibuprofen in postsurgical pain model: A randomized, double-blind, case-control clinical trial.
abstract: BACKGROUND
  Ginger has been used as an herbal drug for a long time for the treatment of chronic inflammatory conditions.
  
  
  METHODS
  This randomized, double-blind clinical trial was conducted on 67 healthy adults with at least one impacted lower third molar. Participants were randomly allocated into three groups: Ibuprofen, Ginger, and placebo. Evaluation of inflammation was done by measuring cheek swelling, mouth opening ability, serum C-reactive protein (CRP) levels, and visual analog scale (for pain scoring). The number and the time of using rescue medication were recorded too.
  
  
  RESULTS
  Sixty patients completed the study. In all three groups, there was a significant increase in the mean cheek swelling measures, compared with the baseline, until day 5. The reduction in mouth opening ability was significant in all three groups, compared with the baseline, until day 5. There was no significant difference between ibuprofenand ginger groups in pain scores in all follow-up days. Number of required rescue medication on the day of surgery was significantly more in the placebo group. No significant or strong correlations were found between CRP levels and clinical findings.
  
  
  CONCLUSIONS
  Within the limitations of this study, it can ban be concluded that gingerpowder is as effective as ibuprofenin the management of postsurgical sequelae. Furthermore, CRP levels alone are not suggested for the assessment of anti-inflammatory effects of drugs.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Rayati
authors.affiliation: Department of Clinical and Anatomical Pathology, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Hajmanouchehri
authors.affiliation: Department of Orthodontics, School of Dentistry, Islamic Azad University of Isfahan, Isfahan, Iran.
authors.forename: Elnaz
authors.initials: E
authors.lastname: Najafi
keywords: C-reactive protein; Ginger; Ibuprofen; surgery; third molar