title: Oncogenic Role of SET/I2PP2A for Gynecologic Cancers.
abstract: SET (SE translocation, SET) is an evolutionarily conserved gene broadly expressed in various human tissues, especially in the gonadal and neural system. As a multitasking protein, SET is involved in essential cell processes such as histone modification, chromatin remodeling, DNA repair, gene transcription, and androgen synthesis. Recent studies showed that SET is overexpressed in breast cancers, ovary cancers and a variety of other malignancies. The strong correlation between SET expression levels and survival of ovarian cancer patients, and SET-mediated activation of androgen synthesis, strongly indicated that this factor may play a significant role in gynecologic cancers. Here, we summarized data pertaining to the pathological implications of SET in tumorigenesis and cancer progression. We analyzed how SET, through the PP2A-dependent and PP2A-independent pathways, may regulate different cell functions. Potential interactions among these pathways and future studies on SET's oncogenic activities are also discussed.
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
authors.forename: Shi-Wen
authors.initials: SW
authors.lastname: Jiang
authors.affiliation: The State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Siliang
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Histology and Embryology, Shantou University Medical College, Shantou, Guangdong 515000, China.
authors.forename: Haibin
authors.initials: H
authors.lastname: Chen
authors.affiliation: The State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Jiayin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Duan
mesh_terms: D004268:DNA-Binding Proteins; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005833:Genital Neoplasms, Female / Q000235:genetics* / Q000473:pathology*; D056488:Histone Chaperones / Q000235:genetics*; D006801:Humans; D011379:Prognosis; D054648:Protein Phosphatase 2 / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics*; D015854:Up-Regulation
chemical_list: D004268:DNA-Binding Proteins; D056488:Histone Chaperones; C513473:SET protein, human; D014157:Transcription Factors; D054648:Protein Phosphatase 2
keywords: I2PP2A; INHAT; PP2A; SET; gynecologic cancer; histone chaperone; steroid hormone