title: Chemerin as a marker of subclinical cardiac involvement in psoriatic patients.
abstract: BACKGROUND
  Chemerin has been associated with psoriasis and inflammation, but there are no studies demonstrating an association between chemerin and subclinical cardiac involvement in psoriatic patients. Therefore, the present study aimed to evaluate whether psoriatic patients with increased epicardial fat tissue, impaired flow-mediated dilatation, and diastolic dysfunction have higher serum chemerin levels than a healthy control group.
  
  
  METHODS
  The study included 60 psoriatic patients and 32 healthy controls. Echocardiographic parameters, epicardial fat tissue, flow-mediated dilatation, and chemerin levels were recorded for both groups.
  
  
  RESULTS
  The serum levels of chemerin in the psoriatic patients were significantly higher than in the control group. The diastolic function parameters, including isovolumic contraction and relaxation time, E'/A' (early diastolic mitral annular velocity/late diastolic mitral annular velocity), and E/E' (early diastolic peak velocity of mitral inflow/early diastolic mitral annular velocity) values, differed significantly between the groups. Epicardial fat tissue was significantly higher and flow-mediated dilatation was significantly lower in psoriatic patients than in the controls. Chemerin was significantly positively correlated with age, body mass index, systolic and diastolic blood pressures, waist circumference, E/E', and epicardial fat tissue. Serum chemerin was significantly negatively correlated with E', E'/A', and flow-mediated dilatation. A multiple linear regression analysis showed that chemerin was independently correlated with E/E'.
  
  
  CONCLUSIONS
  Psoriatic patients exhibit early subclinical atherosclerosis and diastolic dysfunction. Chemerin can be used as a marker to screen for patients with subclinical cardiac involvement.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, Turkey. feyzaulusoyaksu@yahoo.com.
authors.forename: Feyza
authors.initials: F
authors.lastname: Aksu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Caliskan
authors.forename: Nursen
authors.initials: N
authors.lastname: Keles
authors.forename: Aybala
authors.initials: A
authors.lastname: Erek Toprak
authors.forename: Tugba Kevser
authors.initials: TK
authors.lastname: Uzuncakmak
authors.forename: Osman
authors.initials: O
authors.lastname: Kostek
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yilmaz
authors.forename: Kenan
authors.initials: K
authors.lastname: Demircioglu
authors.forename: Esad
authors.initials: E
authors.lastname: Cekin
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozturk
authors.forename: Ayse Serap
authors.initials: AS
authors.lastname: Karadag
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity / Q000502:physiology*; D015992:Body Mass Index; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D002311:Cardiomyopathy, Dilated / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D018925:Chemokines / Q000097:blood*; D003971:Diastole; D004452:Echocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D010496:Pericardium / Q000000981:diagnostic imaging; D011565:Psoriasis / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies; D014463:Ultrasonography / Q000379:methods
chemical_list: D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human
keywords: chemerin; epicardial fat tissue; flow-mediated dilatation; psoriasis