title: The association of enzymatic and non-enzymatic antioxidant defense parameters with inflammatory markers in patients with exudative form of age-related macular degeneration.
abstract: There are evidence that oxidative stress and inflammation are involved in the pathogenesis of the age-related macular degeneration (AMD). The aim of this study was to analyze the antioxidant defense parameters and inflammatory markers in patients with exudative form of AMD (eAMD), their mutual correlations and association with the specific forms of AMD. The cross-sectional study, included 75 patients with the eAMD, 31 patients with the early form, and 87 aged-matched control subjects. Significantly lower SOD, TAS and albumin values and higher GR, CRP and IL-6 were found in the eAMD compared to the early form (p<0.05). Significant negative correlations were found between GPx and fibrinogen (r= -0.254), TAS and IL-6 (r= -0.999) and positive correlations between uric acid and CRP (r= 0.292), IL-6 and uric acid (r= 0.398) in the eAMD. A significant association of CRP (OR: 1.16, 95% CI: 1.03-1.32,p= 0.018), fibrinogen (OR: 2.21, 95% CI: 1.14-4.85,p= 0.021), TAS (OR: 7.45, 95% CI: 3.97-14.35,p= 0.0001), albumin (OR: 1.25, 95% CI: 1.11-1.41,p= 0.0001) and uric acid (OR: 1.006, 95% CI: 1.00-1.02,p= 0.003) was found with the eAMD. In conclusion it may be suggested, there is a significant impairment of antioxidant and inflammatory parameter levels in eAMD patients. In addition, significant association exists between the tested inflammatory markers and antioxidant parameters with late-eAMD.
authors.affiliation: Institute of Medical Biochemistry, Clinical Center of Serbia, School of Pharmacy, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Emina
authors.initials: E
authors.lastname: Čolak
authors.affiliation: Institute of Medical Biochemistry, Clinical Center of Serbia, School of Pharmacy, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ignjatović
authors.affiliation: Institute of Ophthalmology, Medical Retina Department, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade 11000, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Radosavljević
authors.affiliation: Clinic for Eye Diseases, Clinical Center, Faculty of Medicine, Settlement Kosovska Mitrovica, Kosovska Mitrovica 38200, Serbia.
authors.forename: Lepša
authors.initials: L
authors.lastname: Žorić
keywords: age-related macular degeneration; antioxidants; inflammation; oxidative stress