title: S. pombeplaced on the prion map.
abstract: Schizosaccharomyces pombehas been used extensively as a model organism, however it is only recently that the first prion in this organism, a copper transporter protein encoded byctr4,has been conclusively demonstrated. Prions are found in a wide range of organisms and have been implicated in a number of human neurodegenerative diseases. Research into the biology of prions has been carried out mainly in the budding yeastSaccharomyces cerevisiae,however there are many questions still to be addressed.Now, with the identification of the Ctr4 prion inS. pombe,further work in the two yeasts and comparisons of prion biology in these organisms should lead to a greater understanding of prions and their role in disease.
authors.affiliation: Cell Cycle Laboratory, The Francis Crick Institute, I, Midland Road, London NW1 1AT, United Kingdom.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Hayles
keywords: Ctr4; Hsp104; S. pombe; fission yeast; prion