title: Hf(OTf)4-Catalyzed highly diastereoselective synthesis of 1,3-disubstituted tetralin derivatives via benzylic C(sp3)-H bond functionalization.
abstract: We report a highly diastereoselective synthesis of 1,3-disubstituted tetralin derivatives via Lewis acid catalyzed benzylic C(sp3)-H bond functionalization. The employment of Hf(OTf)4as an acid catalyst was crucial in the reaction, and corresponding tetralins were obtained in good chemical yields with high to excellent diastereoselectivities (up to 13.3 : 1 d.r.).
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan. k_mori@cc.tuat.ac.jp.
authors.forename: Taira
authors.initials: T
authors.lastname: Yoshida
authors.forename: Keiji
authors.initials: K
authors.lastname: Mori