title: Nocturnal Desaturation is Associated With Atrial Fibrillation in Patients With Ischemic Stroke and Obstructive Sleep Apnea.
abstract: OBJECTIVE
  Both atrial fibrillation (AF) and obstructive sleep apnea (OSA) are risk factors for ischemic stroke. Previous studies suggested that OSA is associated with AF in individuals who have not had a stroke. For better secondary prevention of stroke, this study determined the association between OSA and AF among patients with ischemic stroke.
  
  
  METHODS
  This cross-sectional study recruited consecutive patients with subacute ischemic stroke admitted for neurorehabilitation. The baseline and clinical data were collected, and standard polysomnography was performed in a sleep center.
  
  
  RESULTS
  The 47 women and 111 men enrolled in this study were divided into two groups according to the presence of AF. The AF group (n = 26) had a significantly older age (72.2 versus 60.1 years,P= .016), significantly more disability (Barthel index: 35 versus 45,P= .045), and marginally higher mean oxygen desaturation (6.7% versus 5.6%,P= .079) compared to the non-AF group. The two groups did not significantly differ in sex, body mass index, prevalence of hyperthyroidism, and other parameters of OSA. The multivariate logistic regression analysis revealed that mean desaturation was significantly associated with AF after adjusting for age, neck circumference, Barthel index and high-density lipoprotein level (odds ratio = 1.19 (95% confidence interval 1.05-1.35),P= .008).
  
  
  CONCLUSIONS
  Nocturnal hypoxia due to OSA is an independent predictor of AF in patients with subacute ischemic stroke. The use of overnight pulse oximeter to assess nocturnal hypoxia and predict paroxysmal AF in patients with cryptogenic stroke needs further evaluation.
  
  
  CONCLUSIONS
  A commentary on this article appears in this issue on page 667.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan.|School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chung-Yao
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Chien-Hui
authors.initials: CH
authors.lastname: Ho
authors.affiliation: Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.|Graduate Institute of Early Intervention, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Chia-Ling
authors.initials: CL
authors.lastname: Chen
authors.affiliation: School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.|Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan.
authors.forename: Chung-Chieh
authors.initials: CC
authors.lastname: Yu
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000150:complications* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology; D020521:Stroke / Q000150:complications* / Q000503:physiopathology
keywords: atrial fibrillation; hypoxia; ischemic stroke; obstructive sleep apnea