title: Effects of Uric Acid on Lipid Levels in CKD Patients in a Randomized Controlled Trial.
abstract: BACKGROUND
  Few studies have been conducted that compared lipid levels and uric acid in CKD or End-Stage Renal Disease (ESRD) patients with most using animal models. The purpose of the study was to explore effects on lipids while controlling uric acid levels in CKD patients.
  
  
  METHODS
  Twenty-four CKD patients (N = 24) volunteered to participate in this study. The study was conducted using a double-blind, randomized, placebo controlled experimental protocol. The experimental group was prescribed 300 mg of allopurinol PO daily by their treating physician and followed prospectively for 8-weeks. The control group consumed a similar pill once a day for 8-weeks.
  
  
  RESULTS
  ANCOVA revealed significant differences in total cholesterol (P = 0.009) and Apo B (P = 0.006) with lower levels in the allopurinol group. A trend emerged with LDL (P = 0.052) with lower levels in the allopurinol group. No significant differences were discovered in triglycerides (P = 0.403), HDL (P = 0.762) and total Cholesterol/HDL Ratio (P = 0.455).
  
  
  CONCLUSIONS
  After statistically controlling for compliance and inflammation significant differences between groups were observed for total cholesterol and Apo B. In both instances the allopurinol group had lower concentrations than the placebo group. Similarly, a trend was observed in LDL with the allopurinol group having lower concentrations than the placebo group.
authors.affiliation: Baylor University, Waco, TX, USA.
authors.forename: Rodney G
authors.initials: RG
authors.lastname: Bowden
authors.affiliation: Baylor University, Waco, TX, USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Shelmadine
authors.affiliation: Baylor University, Waco, TX, USA.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Moreillon
authors.affiliation: Texas Lutheran University, Austin, Texas, USA.
authors.forename: Erika
authors.initials: E
authors.lastname: Deike
authors.affiliation: Family Medicine, Family Health Center. Waco, Texas, USA.
authors.forename: Jackson O
authors.initials: JO
authors.lastname: Griggs
authors.affiliation: Central Texas Nephrology Associates, Waco, Texas, USA.
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Wilson
keywords: Cholesterol; Chronic kidney disease; HDL; LDL; Uric acid