title: Use of the Novel Derivatizing Agent 1,8-Diaminonapthalene With the CIP10 Sampler to Measure 4,4'-Methylene Diphenyl Diisocyanate Atmospheres.
abstract: DAN is a novel derivatizing agent for isocyanate sampling which targets total reactive isocyanate group (TRIG). Field evaluations have been conducted for 4,4'-Methylene diphenyl diisocyanate (MDI) sampling using DAN as the derivatizing agent in a CIP10. The perimidone formed, selective of TRIG, was analyzed in laboratory by liquid chromatography coupled to tandem mass spectrometry. Workplaces using MDI-based polyurethane spray foam and MDI wood product binder were studied. Each study compared the data obtained between the CIP10/DAN, the CIP10/MP, and a reference method. As a first evaluation, the CIP10/DAN sampled simulated MDI spray foam atmosphere in parallel with impingers (reference method) and CIP10/MP. The mean of the TRIG concentration values measured was 16% (95% confidence interval [CI], [1, 31]) higher for the CIP10/MP samples as compared to the impinger samples, while the mean TRIG concentrations found were 98% (95% CI [63, 133]) higher for the CIP10/DAN samples as compared to the impinger samples. For sampling done in a real workplace using MDI-based spray foam, the CIP10/DAN method showed lower results than the CIP10/MP method. The presence of hygroscopic DMSO used in the DAN approach is a limitation and may prevent obtaining accurate results in the spray foam atmosphere. CIP10/DAN was also studied in MDI wood product binder atmosphere. Mean TRIG concentrations found were 80% (95% CI [51, 110]) and 79% (95% CI [50, 108]) lower for the CIP10/MP and CIP10/DAN method, respectively, as compared to the reference method (a 13-mm filter coated with MP). In this case, the CIP10 may have reached its limit in this last evaluation where vapors and particles below 1 µm were not collected as efficiently as they were with the reference method.
authors.affiliation: Laboratory Division, Institut de recherche Robert-Sauvé en santé et en Sécurité du travail, 505 Boulevard De Maisonneuve Ouest, Montréal, Québec H3A 3C2, Canada.
authors.forename: Silvia
authors.initials: S
authors.lastname: Puscasu
authors.affiliation: Laboratory Division, Institut de recherche Robert-Sauvé en santé et en Sécurité du travail, 505 Boulevard De Maisonneuve Ouest, Montréal, Québec H3A 3C2, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Aubin
authors.affiliation: Laboratory Division, Institut de recherche Robert-Sauvé en santé et en Sécurité du travail, 505 Boulevard De Maisonneuve Ouest, Montréal, Québec H3A 3C2, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Sarazin
authors.affiliation: Laboratory Division, Institut de recherche Robert-Sauvé en santé et en Sécurité du travail, 505 Boulevard De Maisonneuve Ouest, Montréal, Québec H3A 3C2, Canada.
authors.forename: Lucile
authors.initials: L
authors.lastname: Richard
authors.affiliation: International Isocyanate Institute, III Scientific Office, Bridgewater House, Whitworth Street, Manchester M1 6LT, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Spence
authors.affiliation: Laboratory Division, Institut de recherche Robert-Sauvé en santé et en Sécurité du travail, 505 Boulevard De Maisonneuve Ouest, Montréal, Québec H3A 3C2, Canada.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Gagné
mesh_terms: D015081:2-Naphthylamine / Q000031:analogs & derivatives*; D000395:Air Pollutants, Occupational / Q000032:analysis*; D002853:Chromatography, Liquid; D004784:Environmental Monitoring / Q000295:instrumentation*; D006801:Humans; D017953:Isocyanates / Q000032:analysis*; D016273:Occupational Exposure / Q000032:analysis*; D011140:Polyurethanes; D053719:Tandem Mass Spectrometry / Q000379:methods; D001559:Benzhydryl Compounds
chemical_list: D015081:2-Naphthylamine; D000395:Air Pollutants, Occupational; D017953:Isocyanates; D011140:Polyurethanes; C028279:polyurethane foam; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds; C508862:1,8-diaminonaphthalene
keywords: 1,8-diaminonaphthalene; exposure assessment methodology; isocyanate; methylene diphenyl diisocyanate; perimidone