title: Industrial release of fluoroquinolones (FQs) in the waste water bodies with their associated ecological risk in Pakistan.
abstract: The unchecked production and use of fluoroquinolones (FQs) for the treatment of infections in human and livestock has increased in Pakistan, which resulted in large amount of antibiotics in water bodies. In the current study, the prevalence and associated ecological risk of three FQs were investigated in waste-water bodies and sludge samples of Kahuta and Hattar industrial zones. The average concentrations of ciprofloxacin (CIP), enrofloxacin (ENR) and levofloxacin (LEV) in the waste-water samples were slightly higher in Kahuta (i.e. 58, 32.9, and 36.7μgL-1respectively), than those in Hattar sites (i.e. 42.1, 41.2, and 48.9μgL-1respectively). However, the concentrations of CIP, ENR and LEV in the sludge samples were significantly higher (i.e. 159; 153 and 164μgkg-1respectively) in Hattar sites, compared to those in Kahuta sites (i.e. 129, 58 and 91μgkg-1respectively). The uses of FQs in the health sector resulted in water pollution and poses the ecological risk to aquatic organisms. The individual risk associated with CIP was highest in Kahuta industrial sites for green algae ranging (2900-9100) followed by M. aeruginosa (5800-18200), cyanobacteria (580-18204) and invertebrates (24.2-75.8). These values suggested that the prevalence of antibiotics in the waste-disposal sites could be potential risk for the aquatic ecosystem, and harmful to biodiversity.
authors.affiliation: Department of Environmental Sciences, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi 46000, Pakistan. Electronic address: luqman_riaz167@yahoo.com.
authors.forename: Luqman
authors.initials: L
authors.lastname: Riaz
authors.affiliation: Department of Environmental Sciences, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi 46000, Pakistan.
authors.forename: Tariq
authors.initials: T
authors.lastname: Mahmood
authors.affiliation: Department of Environmental Sciences, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi 46000, Pakistan.
authors.forename: Atif
authors.initials: A
authors.lastname: Kamal
authors.affiliation: Department of Environmental Sciences, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi 46000, Pakistan.
authors.forename: Mateen
authors.initials: M
authors.lastname: Shafqat
authors.affiliation: Department of Environmental Sciences, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi 46000, Pakistan.
authors.forename: Audil
authors.initials: A
authors.lastname: Rashid
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000633:toxicity; D000460:Chlorophyta / Q000187:drug effects; D000458:Cyanobacteria / Q000187:drug effects; D003621:Daphnia / Q000187:drug effects; D004784:Environmental Monitoring; D005399:Fishes; D024841:Fluoroquinolones / Q000032:analysis / Q000633:toxicity; D007448:Invertebrates / Q000187:drug effects; D010154:Pakistan; D018570:Risk Assessment; D062065:Wastewater / Q000032:analysis / Q000633:toxicity; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D062065:Wastewater; D014874:Water Pollutants, Chemical
keywords: Antibiotics; Ecological risk; Fluoroquinolones; Pakistan