title: 5-HT1A Receptors Mediate Analgesia Induced by Emulsified Sevoflurane in Thermal Nociception but Have Little Effect on Chemical Nociception.
abstract: OBJECTIVE
  The study aimed to investigate the relationship between the analgesic effect of sevoflurane and 5-serotonin receptor 1A (5-HT1A R) in the spinal cords of mice.
  
  
  METHODS
  Analgesic mouse models were established by intraperitoneal injection of emulsified sevoflurane, and the influence of p-MPPF (a specific antagonist of 5-HT1A Rs) intrathecal injection on the changes in tail-flick latency in tail-withdrawal test, pain threshold in hot-plate test (HPPT), and writhing times in acetic acid-induced writhing test were recorded.
  
  
  RESULTS
  Intraperitoneal injection of emulsified sevoflurane alone produced an analgesic effect (p < 0.05). p-MPPF (2, 4, and 8 μg) alone had no impact on tail-flick latency, HPPT, and writhing times in mice (p > 0.05). The 3 doses of p-MPPF reduced the tail-flick latency or HPPT. p-MPPF 8 μg can increase the writhing times (p < 0.05) in analgesic mice with sevoflurane, while p-MPPF 2 and 4 μg did not affect the writhing times.
  
  
  CONCLUSIONS
  5-HT1A Rs in the spinal cord may be an important target for the analgesic effect of sevoflurane on the thermal nociception, but it has little relation to the anti-chemical chemical nociceptive effect of sevoflurane.
authors.affiliation: The First People's Hospital of Changzhou, Changzhou, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yan
authors.forename: Dai
authors.initials: D
authors.lastname: Ti-Jun
authors.forename: Li
authors.initials: L
authors.lastname: Xin
authors.forename: Cao
authors.initials: C
authors.lastname: Gao
authors.forename: Jiang
authors.initials: J
authors.lastname: Shen
authors.forename: Tao
authors.initials: T
authors.lastname: Hong
authors.forename: Meng
authors.initials: M
authors.lastname: Zhi-Xiu
mesh_terms: D000631:Aminopyridines / Q000008:administration & dosage / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D007278:Injections, Spinal; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D051379:Mice; D059225:Nociception / Q000187:drug effects; D010146:Pain / Q000188:drug therapy* / Q000473:pathology; D017288:Pain Threshold / Q000187:drug effects; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects / Q000378:metabolism*; D000077149:Sevoflurane; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism
chemical_list: D000631:Aminopyridines; D000700:Analgesics; D008738:Methyl Ethers; D010879:Piperazines; D044282:Receptor, Serotonin, 5-HT1A; D000077149:Sevoflurane; C099463:4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine
keywords: 5-HT1A receptor; Analgesia; Sevoflurane