title: T cell metabolism in metabolic disease-associated autoimmunity.
abstract: This review discusses the relevant metabolic pathways and their regulators which show potential for T cell metabolism-based immunotherapy in diseases hallmarked by both metabolic disease and autoimmunity. Multiple therapeutic approaches using existing pharmaceuticals are possible from a rationale in which T cell metabolism forms the hub in dampening the T cell component of autoimmunity in metabolic diseases. Future research into the effects of a metabolically aberrant micro-environment on T cell metabolism and its potential as a therapeutic target for immunomodulation could lead to novel treatment strategies for metabolic disease-associated autoimmunity.
authors.affiliation: Division of Biopharmaceutics, LACDR, Leiden University, Leiden, The Netherlands. Electronic address: j.amersfoort@lacdr.leidenuniv.nl.
authors.forename: Jacob
authors.initials: J
authors.lastname: Amersfoort
authors.affiliation: Division of Biopharmaceutics, LACDR, Leiden University, Leiden, The Netherlands.
authors.forename: Johan
authors.initials: J
authors.lastname: Kuiper
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology*; D015551:Autoimmunity; D060833:Cellular Microenvironment; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008659:Metabolic Diseases / Q000150:complications / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
keywords: Autophagy; Cellular metabolism; Diabetes; Dyslipidemia; T cells; Therapeutics