title: Transcriptional variations in biomarkers of Mytilus galloprovincialis sampled from Central Adriatic coastal waters (Marche region, Italy).
abstract: OBJECTIVE
  this work evaluates the expression of several biomarker genes (i.e. CAT, HSPs, MT10, p53, GSTpi, ER1/2) in Mytilus galloprovincialis native specimens to identify pollution related transcriptional changes.
  
  
  METHODS
  gene expression levels were analysed in the gills of mussels from five sites along a coastal area of the central Adriatic Sea, using qPCR.
  
  
  RESULTS
  we observed higher expression levels of biomarker genes in mussels from the local harbour or river mouths than in mussels from the reference site and offshore platform.
  
  
  CONCLUSIONS
  the variations in gene expression observed indicated high sensitivity to pollutants, and showed differences among the sampling sites.
authors.affiliation: a School of Biosciences and Veterinary Medicine, University of Camerino , Camerino , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Cocci
authors.affiliation: a School of Biosciences and Veterinary Medicine, University of Camerino , Camerino , Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Capriotti
authors.affiliation: a School of Biosciences and Veterinary Medicine, University of Camerino , Camerino , Italy.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Mosconi
authors.affiliation: a School of Biosciences and Veterinary Medicine, University of Camerino , Camerino , Italy.
authors.forename: Francesco Alessandro
authors.initials: FA
authors.lastname: Palermo
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D020869:Gene Expression Profiling; D005880:Gills / Q000378:metabolism; D007558:Italy; D049878:Mytilus / Q000378:metabolism*; D014158:Transcription, Genetic; D014874:Water Pollutants, Chemical / Q000032:analysis; D014876:Water Pollution / Q000032:analysis
chemical_list: D015415:Biomarkers; D014874:Water Pollutants, Chemical
keywords: Adriatic Sea; biomarkers; gene transcription; molecular effects; mussel; qRT-PCR