title: Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces.
abstract: Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.
authors.forename: Qi
authors.initials: Q
authors.lastname: Fang
authors.forename: Luke
authors.initials: L
authors.lastname: Frewer
authors.forename: Philip
authors.initials: P
authors.lastname: Wijesinghe
authors.forename: Wes M
authors.initials: WM
authors.lastname: Allen
authors.forename: Lixin
authors.initials: L
authors.lastname: Chin
authors.forename: Juliana
authors.initials: J
authors.lastname: Hamzah
authors.forename: David D
authors.initials: DD
authors.lastname: Sampson
authors.forename: Andrea
authors.initials: A
authors.lastname: Curatolo
authors.forename: Brendan F
authors.initials: BF
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D054459:Elasticity Imaging Techniques; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008099:Liver / Q000166:cytology / Q000000981:diagnostic imaging; D051379:Mice; D019047:Phantoms, Imaging; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*