title: The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.
abstract: Coral reefs are of major ecological and socio-economic interest. They are threatened by global warming and natural pressures such as solar ultraviolet radiation. While great efforts have been made to understand the physiological response of corals to these stresses, the signalling pathways involved in the immediate cellular response exhibited by corals remain largely unknown. Here, we demonstrate that c-Jun N-terminal kinase (JNK) activation is involved in the early response of corals to thermal and UV stress. Furthermore, we found that JNK activity is required to repress stress-induced reactive oxygen species (ROS) accumulation in both the coral Stylophora pistillata and human skin cells. We also show that inhibiting JNK activation under stress conditions leads to ROS accumulation, subsequent coral bleaching and cell death. Taken together, our results suggest that an ancestral response, involving the JNK pathway, is remarkably conserved from corals to human, protecting cells from the adverse environmental effects.
authors.affiliation: Centre Scientifique de Monaco, Marine Department, 8 Quai Antoine Ier, MC-98000 Monaco, Principality of Monaco.|Sorbonne Universités, UPMC Univ Paris 06 IFD-ED 129, 4 Place Jussieu, 75252 PARIS cedex 05, France.|UMR ENTROPIE (IRD, Université de La Réunion, CNRS), Laboratoire d'Excellence « CORAIL», BP A5, 98848, Nouméa cedex, New Caledonia.
authors.forename: Lucile
authors.initials: L
authors.lastname: Courtial
authors.affiliation: Centre Scientifique de Monaco, Biomedical Department, 8 Quai Antoine Ier, MC-98000 Monaco, Principality of Monaco.
authors.forename: Vincent
authors.initials: V
authors.lastname: Picco
authors.affiliation: Centre Scientifique de Monaco, Marine Department, 8 Quai Antoine Ier, MC-98000 Monaco, Principality of Monaco.
authors.forename: Renaud
authors.initials: R
authors.lastname: Grover
authors.affiliation: Centre Scientifique de Monaco, Biomedical Department, 8 Quai Antoine Ier, MC-98000 Monaco, Principality of Monaco.
authors.forename: Yann
authors.initials: Y
authors.lastname: Cormerais
authors.affiliation: Centre Scientifique de Monaco, Marine Department, 8 Quai Antoine Ier, MC-98000 Monaco, Principality of Monaco.
authors.forename: Cécile
authors.initials: C
authors.lastname: Rottier
authors.affiliation: Centre Scientifique de Monaco, Marine Department, 8 Quai Antoine Ier, MC-98000 Monaco, Principality of Monaco.
authors.forename: Antoine
authors.initials: A
authors.lastname: Labbe
authors.affiliation: Centre Scientifique de Monaco, Biomedical Department, 8 Quai Antoine Ier, MC-98000 Monaco, Principality of Monaco.|University Nice Sophia-Antipolis, Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR7284/INSERM U1081, Centre Antoine Lacassagne, Nice 06189, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Pagès
authors.affiliation: Centre Scientifique de Monaco, Marine Department, 8 Quai Antoine Ier, MC-98000 Monaco, Principality of Monaco.
authors.forename: Christine
authors.initials: C
authors.lastname: Ferrier-Pagès
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology; D057894:Coral Reefs; D005347:Fibroblasts / Q000378:metabolism; D057232:Global Warming; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D020935:MAP Kinase Signaling System / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D017382:Reactive Oxygen Species; D048031:JNK Mitogen-Activated Protein Kinases