title: Value of the combined examination of Cys-C and HbA1c for diagnosis of early renal injury in pediatric diabetes.
abstract: The objective of the present study was to evaluate the combined application of measuring cystatin C (Cys-C) and hemoglobin A1c (HbA1c) levels for early renal injury in pediatric patients with type 2 diabetes. A total of 130 children with type 2 diabetes admitted to our hospital from May 2013 to July 2015 were selected. Patients were divided according to whether there was complication of renal injury. In group A (n=65), the patients had renal injury and in group B (n=65), the patients did not have renal injury. The levels of Cys-C and HbA1c in the two groups were examined. The results showed that the levels of Cys-C and HbA1c of patients in group A were significantly higher than those in group B (P<0.05), and the positive rate of the combined examination of Cys-C and HbA1c in group A was 92.3%, and was higher than that of the individual examinations of either Cys-C or HbA1c (P<0.05). The Spearman's correlation coefficient analysis was applied to group B and showed that Cys-C was positively correlated with HbA1c (r=0.842, P<0.05). From analysis of the receiver operating characteristic curves, the combined examination of Cys-C and HbA1c surpassed the individual examinations of Cys-C or HbA1c in sensitivity and specificity (P<0.05). In conclusion, the positive detection rate of early renal injury was significantly increased by the combined examination of Cys-C and HbA1c in pediatric patients with type 2 diabetes, which is beneficial for early identification and diagnosis of this diseases and is worthy of clinical application.
authors.affiliation: Clinical Laboratory, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Tong
authors.initials: T
authors.lastname: Qian
authors.affiliation: Clinical Laboratory, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Tian
authors.affiliation: Clinical Laboratory, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Clinical Laboratory, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Zhenru
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Clinical Laboratory, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Xiuying
authors.initials: X
authors.lastname: Tian
authors.affiliation: Clinical Laboratory, Xuzhou Chlidren's Hospital, Xuzhou, Jiangsu 221002, P.R. China.
authors.forename: Dan
authors.initials: D
authors.lastname: Sun
keywords: Cys-C; HbA1c; renal injury