title: GATA3Gene Polymorphisms Associated with Allergic Rhinitis in an Iranian Population.
abstract: BACKGROUND
  The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association betweenGATA3single nucleotide polymorphisms and AR in an Iranian population was identified.
  
  
  METHODS
  This case-control study was performed on 86 patients with AR and 86 healthy subjects. This study aimed to evaluate a potential association between twoGATA3SNPs, rs1269486 and rs2229360, and AR. Blood samples were collected and DNA was extracted for the evaluation of these SNPs by RFLP-PCR.
  
  
  RESULTS
  A statistically-significant association was found between rs1269486 and AR (P<0.001). The frequencies of the A and GA genotypes were less in patients than in controls. The frequencies of the G allele and the GG genotype were greater in patients than in controls (P < 0.001).
  
  
  CONCLUSIONS
  SNP rs1269486 ofGATA3was associated with AR and sensitivity to aeroallergens in our population. Because of the significance of this gene in AR, studying the association betweenGATA3polymorphisms and AR is recommended for other populations.
authors.affiliation: School of medicine allergy and clinical immunology department, Blusher University of medical science, Blusher Iran.
authors.forename: Afshin
authors.initials: A
authors.lastname: Shirkani
authors.affiliation: Student Research Committee , Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Atena
authors.initials: A
authors.lastname: Mansouri
authors.affiliation: Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Abbaszadegan
authors.affiliation: Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Faridhosseini
authors.affiliation: Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Farahzad
authors.initials: F
authors.lastname: Jabbari Azad
authors.affiliation: Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Gholamin
keywords: Allergic rhinitis; GATA3; Genetic; SNP