title: Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background.
abstract: The data herein is related to the research article entitled "Microbiota-inducible Innate Immune, Siderophore Binding Protein Lipocalin 2 is Critical for Intestinal Homeostasis" (Singh et al., 2016) [1] where we have demonstrated that C57BL/6 Lipocalin 2 deficient mice (Lcn2KO) developed chronic colitis upon anti-interleukin-10 receptor (αIL-10R) monoclonal antibody administration. In the present article, we evaluated the susceptibility of BALB/cLcn2KO mice and their WT littermates to the αIL-10R neutralization-induced chronic colitis. Our data showed that αIL-10R mAb-treated BALB/cLcn2KO mice exhibited severe chronic colitis (i.e., splenomegaly, colomegaly, colonic pathology, and incidence of rectal prolapse) when compared to WT mice.
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Singh
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Beng San
authors.initials: BS
authors.lastname: Yeoh
authors.affiliation: Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA.
authors.forename: Marit
authors.initials: M
authors.lastname: Nilsen-Hamilton
authors.affiliation: The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada M5G 2C1.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Berger
authors.affiliation: The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada M5G 2C1.
authors.forename: Tak W
authors.initials: TW
authors.lastname: Mak
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Matam
authors.initials: M
authors.lastname: Vijay-Kumar
keywords: IL-10; Inflammatory bowel disease; Neutrophil gelatinase-associated lipocalin; Siderocalin