title: Panel 3: Genetics and Precision Medicine of Otitis Media.
abstract: Objective The objective is to perform a comprehensive review of the literature up to 2015 on the genetics and precision medicine relevant to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels were formed comprising experts in the genetics and precision medicine of otitis media. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The entire panel met at the 18th International Symposium on Recent Advances in Otitis Media in June 2015 and discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members. Conclusion Many genes relevant to otitis media have been identified in the last 4 years in advancing our knowledge regarding the predisposition of the middle ear mucosa to commensals and pathogens. Advances include mutant animal models and clinical studies. Many signaling pathways are involved in the predisposition of otitis media. Implications for Practice New knowledge on the genetic background relevant to otitis media forms a basis of novel potential interventions, including potential new ways to treat otitis media.
authors.affiliation: 1 Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Jizhen
authors.initials: J
authors.lastname: Lin
authors.affiliation: 2 Departments of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, Helsinki, Finland.
authors.forename: Lena
authors.initials: L
authors.lastname: Hafrén
authors.affiliation: 3 Department of Otorhinolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kerschner
authors.affiliation: 4 Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Li
authors.affiliation: 5 Medical Research Council Harwell Institute, Oxfordshire, UK.
authors.forename: Steve
authors.initials: S
authors.lastname: Brown
authors.affiliation: 6 Department of Otolaryngology-Head and Neck Surgery, Case Western University, Cleveland, Ohio, USA.
authors.forename: Qing Y
authors.initials: QY
authors.lastname: Zheng
authors.affiliation: 7 Shiekh Zayed Institute for Pediatric Surgical Innovation, Pediatric Otolaryngology, Children's National Health System, Washington, DC, USA.
authors.forename: Diego
authors.initials: D
authors.lastname: Preciado
authors.affiliation: 8 Department of Otolaryngology, Nagoya City University, Nagoya, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: 9 Department of Otolaryngology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Huang
authors.affiliation: 10 Department of Otolaryngology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003226:Congresses as Topic; D008040:Genetic Linkage; D006801:Humans; D009154:Mutation; D010033:Otitis Media / Q000235:genetics*; D057285:Precision Medicine
keywords: genetics; otitis media; precision medicine