title: The Role of Stewardship in Addressing Antibacterial Resistance: Stewardship and Infection Control Committee of the Antibacterial Resistance Leadership Group.
abstract: Antibacterial resistance is increasing globally and has been recognized as a major public health threat. Antibacterial stewardship is the coordinated effort to improve the appropriate use of antibiotics with the aim to decrease selective pressure for multidrug-resistant organisms in order to preserve the utility of antibacterial agents. This article describes the activities of the Antibacterial Resistance Leadership Group (ARLG) in the area of antibacterial stewardship. To date, the ARLG has focused intensely on development of rapid diagnostic tests, which (when coupled with educational and institutional initiatives) will enable the robust stewardship that is needed to address the current crisis of antibacterial resistance. In addition to exploring the effectiveness of stewardship techniques in community hospitals, the ARLG has also developed strategy trials to assess the feasibility of reducing antibacterial usage while preserving patient outcome.
authors.affiliation: Duke Center for Antimicrobial Stewardship and Infection Prevention, Duke University Medical Center, Durham, North Carolina.
authors.forename: Deverick J
authors.initials: DJ
authors.lastname: Anderson
authors.affiliation: Division of Infectious Diseases, Denver Health, Colorado.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Jenkins
authors.affiliation: Center for Biostatistics in AIDS Research and the Department of Biostatistics, Harvard University, Boston, Massachusetts.
authors.forename: Scott R
authors.initials: SR
authors.lastname: Evans
authors.affiliation: University of Maryland School of Medicine, Baltimore.
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Harris
authors.affiliation: Rush University Medical Center, Chicago, Illinois.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Weinstein
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Pranita D
authors.initials: PD
authors.lastname: Tamma
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Han
authors.affiliation: Division of Pediatric Infectious Diseases.
authors.forename: Ritu
authors.initials: R
authors.lastname: Banerjee
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, and.|Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota ; and.
authors.forename: Robin
authors.initials: R
authors.lastname: Patel
authors.affiliation: Division of Infectious Diseases, Children's Hospital of Philadelphia, Pennsylvania.
authors.forename: Theoklis
authors.initials: T
authors.lastname: Zaoutis
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: Ebbing
authors.initials: E
authors.lastname: Lautenbach
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D001431:Bacteriological Techniques; D000068456:Clinical Studies as Topic; D017714:Community-Acquired Infections / Q000188:drug therapy; D024881:Drug Resistance, Bacterial; D006801:Humans; D017053:Infection Control / Q000458:organization & administration*; D007857:Leadership; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology; D012108:Research Personnel / Q000193:education
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibacterial resistance; infection control.; stewardship