title: Associations of Resistin Levels with Resistin Gene Polymorphism and Metabolic Syndrome in Thais.
abstract: BACKGROUND
  Metabolic syndrome (MS) is a clinical constellation comprising risk factors associated with developing cardiovascular disease and type 2 diabetes. Resistin has been suggested as a linkage between obesity, inflammation and type 2 diabetes. This study aimed to investigate resistin concentrations and hematological-biochemical parameters in MS subjects and controls, and to determine whether two resistin gene (RETN)polymorphisms (-420C>G & +299G>A) are linked to resistin levels and MS among Thais.
  
  
  METHODS
  This case-control study was performed with 322 Thai volunteers: 160 MS subjects and 162 controls. Anthropometric parameters and hematological-biochemical variables were determined. TheRETN-420C>G (rs1862513) and +299G>A (rs3745367) polymorphisms were genotyped by PCR-RFLP technique.
  
  
  RESULTS
  The resistin levels of the MS group were significantly higher than those of the control group. Resistin levels were positively correlated with anthropometric parameters and WBC count in the MS group. According toRETN-420C>G polymorphism, MS subjects with the G allele (CG/GG) (3.9 μg/L) had significantly higher resistin concentrations than in subjects with the CC genotype (2.4 μg/L); with regard toRETN+299G>A polymorphism, carriers with the A allele (GA/AA) (3.8 μg/L) had significantly higher resistin levels than subjects with the GG genotype (2.7 μg/L), after adjusting for potential covariates. However, theRETN-420C>G and +299G>A polymorphisms were not found to be associated with MS, hematological-biochemical parameters and anthropometric variables.
  
  
  CONCLUSIONS
  These findings suggest resistin levels are linked with MS and theRETN-420C>G and +299G>A polymorphisms have impacted the circulating resistin concentrations. However, these twoRETNpolymorphisms probably do not influence susceptibility to MS among Thais.
authors.affiliation: Faculty of Medical Technology, Rangsit University, Paholyothin Road Pathumthani, Thailand.
authors.forename: Kanjana
authors.initials: K
authors.lastname: Suriyaprom
authors.affiliation: Department of Tropical Nutrition & Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: Rungsunn
authors.initials: R
authors.lastname: Tungtrongchitr
authors.affiliation: Faculty of Medical Technology, Rangsit University, Paholyothin Road Pathumthani, Thailand.
authors.forename: Pisit
authors.initials: P
authors.lastname: Namjuntra
keywords: Thai; gene polymorphisms; metabolic syndrome; resistin