title: Oropharyngeal squamous cell carcinoma and HPV. Systematic review on overall management.
abstract: BACKGROUND
  Oral human papillomavirus infection amplifies the risk for oropharyngeal cancer. Human papillomavirus-associated cancers in otorhinolaryngology have typical characteristics.
  
  
  METHODS
  To improve understanding of management, therapy and prognosis of patients with oropharyngeal human papillomavirus-associated cancers a systematic review of the literature was reported. Medline, The Cochrane Library, Embase and Scielo electronic databases were searched. The search included published articles up to December 2006. A wide search strategy was employed in order to avoid publication biases and to assess studies in which the main aspects concerning oropharyngeal squamous cell carcinoma and human papillomavirus management are analyzed.
  
  
  RESULTS
  A total of 120 articles were identified, of which 16 matched the inclusion criteria.
  
  
  CONCLUSIONS
  Patients with human papillomavirus-associated oropharyngeal cancers have distinctive risk factors such as a high number of sex partners. They are typically younger, nonusers of tobacco and alcohol and have a better prognosis.
authors.affiliation: ENT Department, Azienda USL 9, Grosseto, Italy. Electronic address: desantis.sante@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: De Santis
authors.affiliation: ENT Department, Dipartimento di Scienze neurologiche e sensoriali, Università di Siena, Viale Bracci, 11, 53100 Siena, Italy. Electronic address: cocabuh@hotmail.it.
authors.forename: M C
authors.initials: MC
authors.lastname: Spinosi
authors.affiliation: ENT Department, Dipartimento di Scienze neurologiche e sensoriali, Università di Siena, Viale Bracci, 11, 53100 Siena, Italy. Electronic address: ishajacopo@hotmail.it.
authors.forename: J
authors.initials: J
authors.lastname: Cambi
authors.affiliation: Oncology Department, Azienda USL 9, Grosseto, Italy. Electronic address: c.bengala@usl9.toscana.it.
authors.forename: C
authors.initials: C
authors.lastname: Bengala
authors.affiliation: ENT Department, Azienda USL 9, Grosseto, Italy. Electronic address: s.boccuzzi@usl9.toscana.it.
authors.forename: S
authors.initials: S
authors.lastname: Boccuzzi
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000628:therapy* / Q000821:virology; D059248:Chemoradiotherapy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy* / Q000821:virology; D014066:Palatine Tonsil / Q000473:pathology; D027383:Papillomaviridae / Q000502:physiology*; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D053918:Papillomavirus Vaccines / Q000627:therapeutic use; D011379:Prognosis; D012307:Risk Factors; D000077195:Squamous Cell Carcinoma of Head and Neck / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D014611:Vaccination / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D053918:Papillomavirus Vaccines
keywords: HPV; Oropharyngeal neoplasms; Palatine tonsil; Review