title: Laser thermal ablation of multidrug-resistant bacteria using functionalized gold nanoparticles.
abstract: The issue of multidrug resistance (MDR) has become an increasing threat to public health. One alternative strategy against MDR bacteria would be to construct therapeutic vectors capable of physically damaging these microorganisms. Gold nanoparticles hold great promise for the development of such therapeutic agents, since the nanoparticles exhibit impressive properties, of which the most important is the ability to convert light into heat. This property has scientific significance since is exploited to develop nano-photothermal vectors to destroy bacteria at a molecular level. The present paper summarizes the latest advancements in the field of nanotargeted laser hyperthermia of MDR bacteria mediated by gold nanoparticles.
authors.affiliation: 3rd Department of General Surgery, "Iuliu Hatieganu" University of Medicine and Pharmacy; Department of Nanomedicine, "Octavian Fodor" Gastroenterology Institute.
authors.forename: Lucian
authors.initials: L
authors.lastname: Mocan
authors.affiliation: Department of Pathology, University of Agricultural Sciences and Veterinary Medicine, Faculty of Veterinary Medicine.
authors.forename: Flaviu A
authors.initials: FA
authors.lastname: Tabaran
authors.affiliation: Department of Nanomedicine, "Octavian Fodor" Gastroenterology Institute; Department of Physiology.
authors.forename: Teodora
authors.initials: T
authors.lastname: Mocan
authors.affiliation: 3rd Gastroenterology Department.
authors.forename: Teodora
authors.initials: T
authors.lastname: Pop
authors.affiliation: 3rd Gastroenterology Department.
authors.forename: Ofelia
authors.initials: O
authors.lastname: Mosteanu
authors.affiliation: Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Lucia
authors.initials: L
authors.lastname: Agoston-Coldea
authors.affiliation: Department of Nanomedicine, "Octavian Fodor" Gastroenterology Institute.
authors.forename: Cristian T
authors.initials: CT
authors.lastname: Matea
authors.affiliation: Department of Nanomedicine, "Octavian Fodor" Gastroenterology Institute.
authors.forename: Diana
authors.initials: D
authors.lastname: Gonciar
authors.affiliation: 3rd Department of General Surgery, "Iuliu Hatieganu" University of Medicine and Pharmacy; Department of Nanomedicine, "Octavian Fodor" Gastroenterology Institute.
authors.forename: Claudiu
authors.initials: C
authors.lastname: Zdrehus
authors.affiliation: 3rd Department of General Surgery, "Iuliu Hatieganu" University of Medicine and Pharmacy.
authors.forename: Cornel
authors.initials: C
authors.lastname: Iancu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D006358:Hot Temperature; D006801:Humans; D006979:Hyperthermia, Induced; D053685:Laser Therapy; D053768:Metal Nanoparticles / Q000737:chemistry*; D010789:Phototherapy
chemical_list: D000900:Anti-Bacterial Agents; D006046:Gold
keywords: antibiotic resistance; bacteria; gold nanoparticles; photo-thermal ablation