title: Systemic therapy for previously untreated advanced BRAF-mutated melanoma: navigating a shifting landscape.
authors.affiliation: Department of Health Research Methods, Evidence, & Impact, McMaster University, Room H306 Martha Wing, St Joseph's Healthcare Hamilton, 50 Charlton Ave. E. Hamilton, ON L8N 4A6, Canada.|Department of Oncology, McMaster University, Hamilton, ON, Canada.
authors.forename: Oren
authors.initials: O
authors.lastname: Levine
authors.affiliation: Department of Health Research Methods, Evidence, & Impact, McMaster University, Room H306 Martha Wing, St Joseph's Healthcare Hamilton, 50 Charlton Ave. E. Hamilton, ON L8N 4A6, Canada.
authors.forename: Tahira
authors.initials: T
authors.lastname: Devji
authors.affiliation: Department of Health Research Methods, Evidence, & Impact, McMaster University, Room H306 Martha Wing, St Joseph's Healthcare Hamilton, 50 Charlton Ave. E. Hamilton, ON L8N 4A6, Canada.|Father Sean O'Sullivan Research Centre, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
authors.forename: Feng
authors.initials: F
authors.lastname: Xie
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D061025:Costimulatory and Inhibitory T-Cell Receptors / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D020930:MAP Kinase Kinase Kinases / Q000037:antagonists & inhibitors; D008545:Melanoma / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D058990:Molecular Targeted Therapy; D009154:Mutation / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D011728:Pyridones / Q000627:therapeutic use; D011744:Pyrimidinones / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D061025:Costimulatory and Inhibitory T-Cell Receptors; D011728:Pyridones; D011744:Pyrimidinones; C560077:trametinib; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D020930:MAP Kinase Kinase Kinases
keywords: BRAF mutation; immune checkpoint inhibitor; melanoma; targeted therapy