title: The Evolutionary Tale and Future Directions of Aromatase Inhibitors in Breast Carcinoma.
abstract: Aromatase inhibitors have often been likened to that of 'medical scalpels' for the treatment of breast carcinoma. By inhibiting the singular step of aromatisation, they have proven to be extremely effective allies in the treatment of breast cancer among postmenopausal women. However, their relevance soon may not be limited to the post-menopausal age group alone. Recent studies have hinted at their utility amongst the premenopausal women; combined with ovarian ablation techniques, aromatase inhibitors may prove to be equally effective and more, as compared to tamoxifen in this age-group. Additionally, explorations aimed at ascertaining their potential utility as an effective preventive strategy against breast carcinoma have yielded encouraging results. However, for aromatase inhibitors to be able to attain their full potential, further strategic fine-tuning aimed at maximising their efficacy and minimising their potentially far-reaching adverse effects, is the need of the hour. Despite the recent diversification, the issue of resistance to aromatase inhibitors in breast cancer threatens to derail the advances so gained till date. Fortunately, a few novel ploys have come to the fore, for instance combining aromatase inhibitors with HER-2 antibodies that could potentially help circumvent the menace of resistance in the near future. Till date, the utility of aromatase inhibitors can at best be described as onedimensional. However, with the unearthing of potential new avenues for its application, this assortment of molecules today stands on the precipice of ushering in a new revolution in the treatment of breast carcinoma.
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Manipal Campus, Manipal University, Manipal, Karnataka, 576104, India.
authors.forename: Dipanjan
authors.initials: D
authors.lastname: Bhattacharjee
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Manipal Campus, Manipal University, Manipal, Karnataka, 576104, India.
authors.forename: K Meena
authors.initials: KM
authors.lastname: Kumari
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Manipal Campus, Manipal University, Manipal, Karnataka, 576104, India.
authors.forename: S
authors.initials: S
authors.lastname: Avin
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Manipal Campus, Manipal University, Manipal, Karnataka, 576104, India.
authors.forename: V Amberkar Mohan
authors.initials: VAM
authors.lastname: Babu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001141:Aromatase / Q000378:metabolism*; D047072:Aromatase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D001141:Aromatase
keywords: Aromatisation; breast neoplasm; evolution; premenopausal age-group; prevention; resistance.