title: LRRK2 and the Immune System.
abstract: Polymorphisms in leucine-rich repeat kinase 2 (LRRK2) have been linked to familial Parkinson's disease, increased risk of sporadic Parkinson's disease, increased risk of Crohn's inflammatory bowel disease, and increased susceptibility to leprosy. As well as LRRK2 mutations, these diseases share in common immune dysfunction and inflammation. LRRK2 is highly expressed in particular immune cells and has been biochemically linked to the intertwined pathways regulating inflammation, mitochondrial function, and autophagy/lysosomal function. This review outlines what is currently understood about LRRK2 function in the immune system and the potential implications of LRRK2 dysfunction for diseases genetically linked to this enigmatic enzyme.
authors.affiliation: School of Medical Sciences, University of NSW, Kensington, NSW, 2052, Australia. n.dzamko@neura.edu.au.|Neuroscience Research Australia, Randwick, NSW, 2031, Australia. n.dzamko@neura.edu.au.
authors.forename: Nicolas L
authors.initials: NL
authors.lastname: Dzamko
mesh_terms: D006801:Humans; D007107:Immune System / Q000276:immunology*; D007154:Immune System Diseases / Q000235:genetics; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / Q000235:genetics / Q000276:immunology*; D009154:Mutation; D010300:Parkinson Disease / Q000235:genetics
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
keywords: Crohn’s disease; Cytokine; Inflammation; Innate immunity; Kinase; Parkinson’s disease