title: A novel mechanism involved in the coupling of mitochondrial biogenesis to oxidative phosphorylation.
abstract: Mitochondria are essential organelles that are central to a multitude of cellular processes, including oxidative phosphorylation (OXPHOS), which produces most of the ATP in animal cells. Thus it is important to understand not only the mechanisms and biogenesis of this energy production machinery but also how it is regulated in both physiological and pathological contexts. A recent study by Ostojićet al.[Cell Metabolism (2013) 18, 567-577] has uncovered a regulatory loop by which the biogenesis of a major enzyme of the OXPHOS pathway, the respiratory complex III, is coupled to the energy producing activity of the mitochondria.
authors.affiliation: Centre de Génétique Moléculaire, Université Paris-Sud, avenue de la Terrasse, 91190 Gif sur Yvette, France.
authors.forename: Jelena
authors.initials: J
authors.lastname: Ostojić
authors.affiliation: University Bordeaux, Institut de Biochimie et Génétique Cellulaires, UMR 5095, 33000 Bordeaux, France. ; CNRS, Institut de Biochimie et Génétique Cellulaires, UMR 5095, 33000 Bordeaux, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Rago
authors.affiliation: Centre de Génétique Moléculaire, Université Paris-Sud, avenue de la Terrasse, 91190 Gif sur Yvette, France.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Dujardin
keywords: AAA protein Bcs1; ATP synthase; OXPHOS complex III; mitochondrial-disease model; yeast