title: Daily dosing of gentamicin using ideal body weight for the treatment of intrapartum chorioamnionitis: a pilot study.
abstract: OBJECTIVE
  This study aimed to determine whether daily dosing of gentamicin using ideal body weight in the treatment of chorioamnionitis is effective.
  
  
  METHODS
  We conducted a prospective observational study and followed all women receiving treatment for chorioamnionitis which included gentamicin daily dosing calculated using 5 mg/kg ideal body weight. Patients were excluded if pathological analysis of placenta did not confirm chorioamnionitis. Our primary outcome was resolution of infection following delivery without the development of maternal endometritis and/or neonatal sepsis. Ninety-five percent confidence intervals for proportions were calculated using exact binomial tests. These patients were retrospectively compared to patients who received treatment for chorioamnionitis which included traditional gentamicin every 8 h.
  
  
  RESULTS
  The study included 160 patients. Of the patients receiving daily dosing (n = 80) compared to traditional dosing (n = 80), 96% (95% CI 95.7-97.6%) achieved the primary outcome versus 91% (88.9-93.1%), 2.5% (95% CI 1.2-3.8%) developed endometritis versus 6.3% (4.2-8.4%), 1.3% (95% CI 0.4-2.2%) delivered neonates with sepsis versus 2.5% (1.2-3.8%), and 39% required cesarean delivery (95% CI 46.2-53.8) versus 37% (33.2-40.8%).
  
  
  CONCLUSIONS
  Daily dosing of gentamicin using ideal body weight is effective in successful treatment of chorioamnionitis without development endometritis and/or neonatal sepsis across different ethnicities.
authors.affiliation: a Department of Obstetrics and Gynecology , NYU Lutheran Medical Center , Brooklyn , NY , USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Martingano
authors.affiliation: a Department of Obstetrics and Gynecology , NYU Lutheran Medical Center , Brooklyn , NY , USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Guan
authors.affiliation: b Department of Clinical Research and Statistics , NYU Lutheran Medical Center , Brooklyn , NY , USA.
authors.forename: Audrey
authors.initials: A
authors.lastname: Renson
authors.affiliation: c Department of Maternal Fetal Medicine , NYU Lutheran Medical Center , Brooklyn , NY , USA.
authors.forename: Shailini
authors.initials: S
authors.lastname: Singh
authors.affiliation: a Department of Obstetrics and Gynecology , NYU Lutheran Medical Center , Brooklyn , NY , USA.
authors.forename: Meera
authors.initials: M
authors.lastname: Kesavan Nasir
authors.affiliation: d Department of Pharmacy , NYU Lutheran Medical Center , Brooklyn , NY , USA.
authors.forename: Juliette
authors.initials: J
authors.lastname: Kim
authors.affiliation: e Department of Infectious Diseases , NYU Lutheran Medical Center , Brooklyn , NY , USA.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Carey
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D002821:Chorioamnionitis / Q000188:drug therapy / Q000473:pathology; D004334:Drug Administration Schedule; D004716:Endometritis / Q000517:prevention & control; D005006:Ethnicity; D005839:Gentamicins / Q000008:administration & dosage; D056865:Ideal Body Weight; D000071074:Neonatal Sepsis / Q000517:prevention & control; D010865:Pilot Projects; D010920:Placenta / Q000473:pathology; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D005839:Gentamicins
keywords: Chorioamnionitis; atepartum infection; gentamicin dosing; pregnancy