title: Short-term effects of Mediterranean-type diet intervention on soluble cellular adhesion molecules in subjects with abdominal obesity.
abstract: OBJECTIVE
  Abdominal obesity (AO) is associated with increased risk for cardiovascular disease and with increased production of adhesion molecules. The present work examined the effect of a Mediterranean-style diet on soluble cellular adhesion molecules in individuals with AO.
  
  
  METHODS
  Ninety subjects with AO without cardiovascular disease or diabetes mellitus were randomly allocated to the intervention or control group and were instructed to follow a Mediterranean-style diet for two months. Intervention group followed a specific relevant food plan with close dietetic supervision and provision of basic foods. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), sP and sE-selectin, C-reactive protein (CRP) and interleukin-6 (IL-6) were measured.
  
  
  RESULTS
  Subjects in the intervention group increased their intake of total fat, monounsaturated fatty acids, dietary fiber, vitamin C, and alcohol compared to controls, while decreased their intake of saturated fat. Although there was a significant decrease in CRP, sP-selectin and in sE-selectin in the intervention group, and an increase in sVCAM-1 in the control group, between-group analysis showed no statistically significant differences. There were also no significant changes in sICAM-1, and IL-6 levels after intervention.
  
  
  CONCLUSIONS
  Mediterranean-type diet for two months combined with close dietetic supervision showed a beneficial tendency towards the down-regulation of some markers of vascular inflammation, although the comparison between groups after the intervention did not reach statistical significance. A longer period of dietary intervention may be required to further support these changes.
authors.affiliation: Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece.
authors.forename: Loukianos S
authors.initials: LS
authors.lastname: Rallidis
authors.affiliation: Unit of Human Nutrition, Department of Food Science and Human Nutrition, Agricultural University of Athens, Greece.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Kolomvotsou
authors.affiliation: Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Lekakis
authors.affiliation: Unit of Human Nutrition, Department of Food Science and Human Nutrition, Agricultural University of Athens, Greece.
authors.forename: Paul
authors.initials: P
authors.lastname: Farajian
authors.affiliation: Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Vamvakou
authors.affiliation: Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Dagres
authors.affiliation: Biochemistry Laboratory, General Hospital of Nikea, Piraeus, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Zolindaki
authors.affiliation: Hygeias Melathron Infirmary, Athens, Greece.
authors.forename: Stamatis
authors.initials: S
authors.lastname: Efstathiou
authors.affiliation: Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Anastasiou-Nana
authors.affiliation: Unit of Human Nutrition, Department of Food Science and Human Nutrition, Agricultural University of Athens, Greece. Electronic address: azampelas@aua.gr.
authors.forename: Antonis
authors.initials: A
authors.lastname: Zampelas
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D038441:Diet, Mediterranean; D015536:Down-Regulation; D005260:Female; D006115:Greece; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D056128:Obesity, Abdominal / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy* / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D018836:Inflammation Mediators
keywords: Abdominal obesity; Cellular adhesion molecules; Intervention; Mediterranean diet