title: Will bevacizumab biosimilars impact the value of systemic therapy in gynecologic cancers?
abstract: OBJECTIVE
  Bevacizumab is an important component in the treatment of various cancers, and despite guidelines recommending its use in both ovarian and cervical cancer, patient access to bevacizumab and other angiogenesis inhibitors is limited. Biosimilars are large, structurally complex molecules that are intended to be highly similar to, and treat the same condition(s) as, an existing licensed or approved (reference) biologic, with no clinically meaningful differences in purity, potency and safety. This article summarizes the role of bevacizumab in the treatment paradigm of ovarian and cervical cancer. We also discuss the potential role of biosimilars to bevacizumab, which may offer more affordable options in the future treatment of gynecologic cancers.
  
  
  METHODS
  Literature searches of PubMed and ClinicalTrials.gov databases were conducted. Regulatory and individual pharmaceutical company web pages were also reviewed. Search terms included "biosimilar" and "bevacizumab," and these were used to identify information regarding biosimilar development, reporting results of biosimilar studies or biosimilars in development.
  
  
  RESULTS
  At present, four bevacizumab biosimilar candidates are undergoing comparative clinical assessment, with the potential to increase access and offer efficiencies across healthcare systems.
  
  
  CONCLUSIONS
  It is anticipated that biologics such as bevacizumab will continue to play a key role in the treatment of an array of gynecologic cancers. Biosimilars to bevacizumab are currently in development and have the potential to increase access to medicines in a variety of settings, including gynecologic cancers.
authors.affiliation: Arizona Oncology (US Oncology Network), University of Arizona College of Medicine, Creighton University School of Medicine at St. Joseph's Hospital, Phoenix, AZ USA.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Monk
authors.affiliation: University of Alabama at Birmingham, Birmingham, AL USA.
authors.forename: Warner K
authors.initials: WK
authors.lastname: Huh
authors.affiliation: Pfizer, Groton, CT USA.
authors.forename: Julie Ann
authors.initials: JA
authors.lastname: Rosenberg
authors.affiliation: Early Oncology Development and Clinical Research, Pfizer, 219 East 42nd Street, New York, NY 10017-5755 USA.
authors.forename: Ira
authors.initials: I
authors.lastname: Jacobs
keywords: Bevacizumab; Biosimilar; Cervical cancer; Ovarian cancer