title: Minocycline for the Treatment of Multidrug and Extensively Drug-Resistant A. baumannii: A Review.
abstract: Acinetobacter baumannii can cause life-threatening nosocomial infections associated with high rates of morbidity and mortality. In recent years, the increasing number of infections due to extensively drug-resistant Acinetobacter with limited treatment options has resulted in a need for additional therapeutic agents, and a renaissance of older, neglected antimicrobials. This has led to an increased interest in the use of minocycline to treat these infections. Minocycline has been shown to overcome many resistance mechanisms affecting other tetracyclines in A. baumannii, including tigecycline. Additionally, it has favorable pharmacokinetic and pharmacodynamic properties, as well as excellent in vitro activity against drug-resistant A. baumannii. Available data support therapeutic success with minocycline, while ease of dosing with no need for renal or hepatic dose adjustments and improved safety have made it an appealing therapy. This review will focus on the mechanisms of action and resistance to tetracyclines in A. baumannii, the in vitro activity, pharmacokinetic and pharmacodynamic properties of minocycline against A. baumannii, and finally the clinical experience with minocycline for the treatment of invasive infections due to this pathogen.
authors.affiliation: Department of Pharmacy, Barnes-Jewish Hospital, Saint Louis, MO, USA. jennifer.lashinsky@bjc.org.
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Lashinsky
authors.affiliation: Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Oryan
authors.initials: O
authors.lastname: Henig
authors.affiliation: Department of Pharmacy Services, Sinai-Grace Hospital, Detroit Medical Center, Detroit, MI, USA.|Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Pogue
authors.affiliation: Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Keith S
authors.initials: KS
authors.lastname: Kaye
keywords: Acinetobacter; Acinetobacter baumannii; Carbapenem resistance; Extensively drug-resistant; Minocycline; Multidrug-resistant; Tetracyclines