title: Multifunctional Nanomaterials and Their Applications in Drug Delivery and Cancer Therapy.
abstract: The field of nanotechnology has led to the development of many innovative strategies for effective detection and treatment of cancer, overcoming limitations associated with conventional cancer diagnosis and therapy. Multifunctional nanoparticle systems can integrate imaging, targeting and treatment moieties on the surface and in the core, resulting in targeted delivery of the imaging or treatment modalities, specifically to the tumor. Multifunctional nanoparticles also enable simultaneous delivery of multiple treatment agents, resulting in effective combinatorial therapeutic regimens against cancer. In this review, various multifunctional nanoparticle systems that feature a variety of targeting moieties forin vitroand/orin vivocancer imaging and therapy are discussed.
authors.affiliation: The Pharmaceutical Research Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA. mathangi.srinivasan@acphs.edu.
authors.forename: Mathangi
authors.initials: M
authors.lastname: Srinivasan
authors.affiliation: The Pharmaceutical Research Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA. mehdi.rajabi@acphs.edu.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Rajabi
authors.affiliation: The Pharmaceutical Research Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA. shaker.mousa@acphs.edu.
authors.forename: Shaker A
authors.initials: SA
authors.lastname: Mousa
keywords: cancer therapy; drug delivery; imaging; multifunctional nanoparticles; nanotechnology; tumor targeting