title: The miR-30 family: Versatile players in breast cancer.
abstract: The microRNA family, miR-30, plays diverse roles in regulating key aspects of neoplastic transformation, metastasis, and clinical outcomes in different types of tumors. Accumulating evidence proves that miR-30 family is pivotal in the breast cancer development by controlling critical signaling pathways and relevant oncogenes. Here, we review the roles of miR-30 family members in the tumorigenesis, metastasis, and drug resistance of breast cancer, and their application to predict the prognosis of breast cancer patients. We think miR-30 family members would be promising biomarkers for breast cancer and may bring a novel insight in molecular targeted therapy of breast cancer.
authors.affiliation: 1 The Fourth Clinical School of Nanjing Medical University, Nanjing, China.|2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Yang
authors.affiliation: 3 Nanjing University of Chinese Medicine, Nanjing, China.
authors.forename: Su-Yu
authors.initials: SY
authors.lastname: Yang
authors.affiliation: 1 The Fourth Clinical School of Nanjing Medical University, Nanjing, China.|2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Wang
authors.affiliation: 1 The Fourth Clinical School of Nanjing Medical University, Nanjing, China.|2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Chen
authors.affiliation: 1 The Fourth Clinical School of Nanjing Medical University, Nanjing, China.|2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Shen
authors.affiliation: 1 The Fourth Clinical School of Nanjing Medical University, Nanjing, China.|4 Center of Clinical Laboratory, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: 4 Center of Clinical Laboratory, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Shan-Liang
authors.initials: SL
authors.lastname: Zhong
authors.affiliation: 2 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Tang
authors.affiliation: 4 Center of Clinical Laboratory, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhao
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009362:Neoplasm Metastasis; D015398:Signal Transduction / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C546086:MIRN30b microRNA, human; D035683:MicroRNAs
keywords: MicroRNA; biomarker; breast cancer; miR-30 family