title: Sex differences in prevalence and risk factors of asymptomatic cholelithiasis in Korean health screening examinee: A retrospective analysis of a multicenter study.
abstract: The aim of this study was to evaluate sex difference in the prevalence and risk factors for asymptomatic cholelithiasis in Korean health screening examinees.Examinees who underwent examination through health promotion center at 5 hospitals of Daegu-Gyeongbuk province in 2014 were analyzed retrospectively. All examinees were checked for height, weight, waist circumference, and blood pressure, and underwent laboratory tests and abdominal ultrasound. Diagnosis of cholelithiasis was made by ultrasound.Of the total of 30,544 examinees, mean age was 47.3 ± 10.9 years and male to female ratio was 1.4:1. Asymptomatic cholelithiasis was diagnosed in 1268 examinees with overall prevalence of 4.2%. In age below 40 years, females showed higher prevalence of asymptomatic cholelithiasis than males (2.7% vs. 1.9%, P = 0.020), whereas prevalence of asymptomatic cholelithiasis was higher in males than females older than 50 years (6.2% vs. 5.1%, P = 0.012). Multiple logistic regression analysis revealed age (≥50 years), obesity, and high blood pressure as risk factors for asymptomatic cholelithiasis in males and age, obesity, hypertriglyceridemia, and chronic hepatitis B infection in females (P < 0.05).Overall prevalence of asymptomatic cholelithiasis was 4.2% in Korean health screening examinees. Females showed higher prevalence of asymptomatic cholelithiasis than males younger than 40 years, whereas it was higher in males older than 50 years. Age and obesity were risk factors for asymptomatic cholelithiasis in both sexes. Males had additional risk factors of high blood pressure and females had hypertriglyceridemia and chronic hepatitis B infection.
authors.affiliation: Department of Internal Medicine, Yeungnam University College of Medicine Department of Internal Medicine, Kyungpook National University School of Medicine Department of Internal Medicine, Keimyung University School of Medicine Department of Internal Medicine, Catholic University of Daegu School of Medicine Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Sung Bum
authors.initials: SB
authors.lastname: Kim
authors.forename: Kook Hyun
authors.initials: KH
authors.lastname: Kim
authors.forename: Tae Nyeun
authors.initials: TN
authors.lastname: Kim
authors.forename: Jun
authors.initials: J
authors.lastname: Heo
authors.forename: Min Kyu
authors.initials: MK
authors.lastname: Jung
authors.forename: Chang Min
authors.initials: CM
authors.lastname: Cho
authors.forename: Yoon Suk
authors.initials: YS
authors.lastname: Lee
authors.forename: Kwang Bum
authors.initials: KB
authors.lastname: Cho
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Lee
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Han
authors.forename: Ho Gak
authors.initials: HG
authors.lastname: Kim
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases / Q000453:epidemiology; D002769:Cholelithiasis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D012727:Sex Characteristics