title: Concept of experimental preparation for treating dentin hypersensitivity.
abstract: BACKGROUND
  Dentinal hypersensitivity (DH) is a diagnostic and therapeutic problem that is now appearing more frequently in modern dentistry. The aim of this work was to elaborate formulation of a new, original desensitizing preparation with prolonged action based on the knowledge of similar commercializations and to compare their performance in vitro.
  
  
  METHODS
  The analyses were performed with the aid of NMR spectroscopy. The experimental and commercial preparations were examined in vitro after thermocycling on human teeth by optical microscopy. The presence of the material on tooth tissue, its ability to penetrate into the tooth structure and its layer thickness were subjected to statistical analysis.
  
  
  RESULTS
  A detailed knowledge on composition of commercial material was achieved from spectroscopic measurements. A new adhesive monomer was synthesized and incorporated into an experimental desensitizing formulation. The new monomer appeared to have comparable performance to the commercial one when regarding the affinity to tooth tissue and resistance to thermocycling.
  
  
  CONCLUSIONS
  The experimental formulation comprising a new adhesive monomer seems to be promising and could be applied in dental practice providing that biocompatibility is satisfactory.
authors.affiliation: Department of Conservative Dentistry with Endodontics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia Medical University of Silesia in Katowice, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Tanasiewicz
authors.affiliation: Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, 44-100 Gliwice, Poland.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Gibas
authors.affiliation: Department of Conservative Dentistry with Endodontics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia Medical University of Silesia in Katowice, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Skucha-Nowak
authors.affiliation: Department of Conservative Dentistry with Endodontics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia Medical University of Silesia in Katowice, Poland.
authors.forename: Henryk
authors.initials: H
authors.lastname: Twardawa
authors.affiliation: Departament of Orthodontics, Chair of Masticatory Dysfunction and Orthodontics School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Machorowska-Pieniążek
keywords: Dental adhesive monomer; Dentin desensitizer; Dentinal hypersensitivity; Nuclear magnetic resonance; Optical microscopy