title: [A clinical analysis on fever of unknown origin in in-patients with systemic lupus erythematosus].
abstract: To investigate the etiology and differential diagnoses of patients with systemic lupus erythematosus (SLE) and fever of unknown origin (FUO). From January 2012 to December 2014, a total of 928 SLE patients were admitted to Peking Union Medical College Hospital.Only 50 patients were combined with FUO (5.4%). The most common reason of fever was caused by infections(33 cases, 66.0%), including bacterial infection in 17 cases with 5 tuberculosis, viral infection in 11 cases, and fungal infection in 5 cases.The second reason offever was due to poor disease control or recurrence in 17 patients (34.0%). No fever was caused by malignant tumor.When clinical data was compared between 17 non-infected patients versus 33 infected patients, C reactive protein and procalcitonin in the infected group were significantly higher than those in the non-infected group.In SLE patients combined with FUO, infection is the most common etiology which is necessary to be paid attention to.
authors.affiliation: Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: C F
authors.initials: CF
authors.lastname: Zhang
authors.forename: R
authors.initials: R
authors.lastname: Xu
authors.forename: M T
authors.initials: MT
authors.lastname: Li
authors.forename: X F
authors.initials: XF
authors.lastname: Zeng
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D002681:China / Q000453:epidemiology; D005260:Female; D005335:Fever of Unknown Origin / Q000453:epidemiology / Q000209:etiology*; D006760:Hospitalization; D006801:Humans; D007239:Infections / Q000150:complications*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000150:complications* / Q000453:epidemiology
chemical_list: D002116:Calcitonin; D002097:C-Reactive Protein
keywords: Fever of unknown origin; Lupus erythematosus, systemic