title: Synthesis and antimicrobial properties of Zn-mineralized alginate nanocomposites.
abstract: New bioactive and antimicrobial biomaterials were produced by alginate-mediated biomineralization with Zn-mineral phase. The synthesis procedure is simple, cost-effective and resulted in two different Zn-mineralized alginate nanocomposites, Zn-carbonate/Zn-alginate and Zn-phosphate/Zn-alginate. The presence of Zn-mineral phase and its type, have significantly affected nanocomposite morphology, stability, total metallic loading and potential to release Zn(II) in physiological environment. Antimicrobial experiments showed that both types of Zn-mineralized nanocomposites exhibit strong antimicrobial effect against Escherichia coli, Staphylococcus aureus and Candida albicans. These results suggest that alginate biomineralization, where minerals are salts of essential metallic ions like Zn(II), represents a good strategy for designing multifunctional biomaterials for potential biomedical applications.
authors.affiliation: Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia. Electronic address: madzovska@tmf.bg.ac.rs.
authors.forename: Ivana
authors.initials: I
authors.lastname: Malagurski
authors.affiliation: Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11000 Belgrade, Serbia.
authors.forename: Steva
authors.initials: S
authors.lastname: Levic
authors.affiliation: Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11000 Belgrade, Serbia.
authors.forename: Milena
authors.initials: M
authors.lastname: Pantic
authors.affiliation: Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11000 Belgrade, Serbia.
authors.forename: Danka
authors.initials: D
authors.lastname: Matijasevic
authors.affiliation: Vinca Institute of Nuclear Science, University of Belgrade, P.O. Box 522, 11001 Belgrade, Serbia.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Mitric
authors.affiliation: Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11000 Belgrade, Serbia.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Pavlovic
authors.affiliation: Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, Serbia.
authors.forename: Suzana
authors.initials: S
authors.lastname: Dimitrijevic-Brankovic
mesh_terms: D000464:Alginates; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites; D013211:Staphylococcus aureus / Q000187:drug effects; D015032:Zinc
chemical_list: D000464:Alginates; D000890:Anti-Infective Agents; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D015032:Zinc
keywords: Alginate; Antimicrobial activity; Biomineralization; Nanocomposite; Zinc