title: Acute kidney injury in children with sickle cell disease-compounding a chronic problem.
abstract: In an article recently published in Pediatric Nephrology, Baddam and colleagues discuss the relatively underreported clinical problem of repeated episodes of acute kidney injury (AKI) in children with sickle cell disease (SCD). Their report is a cautionary note about the importance of repeated kidney injury on the background of underlying chronic kidney injury and its potential implications on long-term kidney outcome. In children and adults with SCD, this includes the effects of repeated vaso-occlusive crises and the management of these painful episodes with non-steroidal anti-inflammatory drugs. Here we review the scope of kidney involvement in SCD in children and discuss the potential short- and long-term consequences of AKI in children with SCD.
authors.affiliation: Department of Pediatrics, University of British Columbia, Vancouver, Canada.|Division of Nephrology, British Columbia Children's Hospital, Vancouver, Canada.
authors.forename: Cherry
authors.initials: C
authors.lastname: Mammen
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: Mei Lin
authors.initials: ML
authors.lastname: Bissonnette
authors.affiliation: Department of Pediatrics, University of British Columbia, Vancouver, Canada. dmatsell@cw.bc.ca.|Division of Nephrology, British Columbia Children's Hospital, Vancouver, Canada. dmatsell@cw.bc.ca.
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Matsell
mesh_terms: D058186:Acute Kidney Injury; D000328:Adult; D000755:Anemia, Sickle Cell; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002648:Child; D006801:Humans; D007668:Kidney; D010146:Pain
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: Acute kidney injury; Children; Non-steroidal anti-inflammatory drugs; Sickle cell nephropathy; Vaso-occlusive pain crisis