title: A Novel PPh3Mediated One-Pot Method for Synthesis of 3-Aryl or Alkyl 1,2-Benzisoxazoles.
abstract: A novel, efficient, and facile protocol has been developed for transforming 2-hydroxybenzonitriles and bromides into a range of 3-aryl or alkyl substituted 1,2-benzisoxazoles in good to excellent yields mediated by PPh3. The electronic and steric effects of bromides on the reaction are discussed. This is the first example to construct a C-C bond and heterocycle in a Barbier-Grignard-type reaction featuring easier recovery of PPh3than a metallic catalyst in one step.
authors.affiliation: Department of Chemistry, College of Chemistry and Materials, Jinan University , Guangzhou 510632, China.
authors.forename: GuiFang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Chemistry, College of Chemistry and Materials, Jinan University , Guangzhou 510632, China.
authors.forename: Hong
authors.identifier: 0000-0002-2856-5930
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Chemistry, College of Chemistry and Materials, Jinan University , Guangzhou 510632, China.
authors.forename: ShuJia
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Chemistry, College of Chemistry and Materials, Jinan University , Guangzhou 510632, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Pharmacy, College of Pharmacy, Jinan University , Guangzhou 510632, China.
authors.forename: PeiYao
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Chemistry, College of Chemistry and Materials, Jinan University , Guangzhou 510632, China.
authors.forename: KaiTian
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Chemistry, College of Chemistry and Materials, Jinan University , Guangzhou 510632, China.
authors.forename: YuanMing
authors.initials: Y
authors.lastname: Zhang