title: Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population.
abstract: Background:Genome-wide association studies have identified that polymorphisms in 8q24 confer susceptibility to gastric cancer. Polymorphisms in the lncRNAPRNCR1,PCAT1, andCCAT2transcribed from the 8q24 locus have a potential risk for gastric cancer.Methods:To evaluate whether there is such an association in Chinese population, a case-control study enrolled 494 patients and 494 healthy controls was carried out. Sequenom MassARRAY platform was used for genotyping.Results:This study showed that rs16901946 G allele was associated with increased risk of gastric cancer (AG: adjusted OR = 1.33, 95% CI =1.02-1.73, p=0.033; GG: adjusted OR = 2.07; 95% CI = 1.11-3.86, p=0.023, AG/GG: adjusted OR = 1.39, 95% CI = 1.08-1.1.79, p=0.011; additive model: adjusted OR = 1.37; 95% CI = 1.10-1.70, p=0.004). Stratified analysis revealed that the increased risk was more evident in the cohort of younger subjects (adjusted OR = 1.84, 95% CI = 1.18-2.87, p=0.007), males (adjusted OR = 1.55, 95% CI = 1.15-2.08, p=0.004), positiveHelicobacter pyloriinfection (adjusted OR = 1.44, 95% CI = 1.02-2.03, p=0.041), gastric cardia adenocarcinoma (adjusted OR = 1.61, 95% CI = 1.10-2.35, p=0.014), and tumor stage T1-T2 (adjusted OR = 1.58, 95% CI = 1.10-2.28, p=0.013).Conclusions:Our study suggested that rs16901946 G allele carriers have an increased risk of gastric cancer, and the risk could be enhanced by the interactions between the polymorphism and age, sex,Helicobacter pyloriinfection.
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Bang-Shun
authors.initials: BS
authors.lastname: He
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Sun
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Pan
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Lin
authors.affiliation: Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Tian-Yi
authors.initials: TY
authors.lastname: Gao
authors.affiliation: Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Shu-Kui
authors.initials: SK
authors.lastname: Wang
keywords: Gastric cancer; lncRNA.; polymorphism