title: Gaining insight into tablet capping tendency from compaction simulation.
abstract: Capping or lamination is an unsolved common problem in tablet manufacturing. Knowledge gaps remain despite an enormous amount of effort made in the past to better understand the tablet capping/lamination phenomenon. Using acetaminophen - containing formulations, we examined the potential use of a compaction simulator as a material-sparing tool to predict capping occurrence under commercial tableting conditions. Systematical analyses of the in-die compaction data led to insight on the potential mechanism of tablet capping/lamination. In general, capping strongly correlates with high in-die elastic recovery, high Poisson's ratio, low tensile strength, and radial die-wall pressure. Such insight can be used to guide the formulation design of high quality tablet products that are free from capping problems for challenging active pharmaceutical ingredients.
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127 B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, United States.
authors.forename: Shubhajit
authors.initials: S
authors.lastname: Paul
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127 B Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, United States. Electronic address: sunx0053@umn.edu.
authors.forename: Changquan Calvin
authors.initials: CC
authors.lastname: Sun
mesh_terms: D000082:Acetaminophen; D002626:Chemistry, Pharmaceutical; D011312:Pressure; D013607:Tablets; D013718:Tensile Strength
chemical_list: D013607:Tablets; D000082:Acetaminophen
keywords: Capping; Compaction simulation; Formulation development; Lamination; Mechanical property; Tableting