title: Antimicrobial sesquiterpene lactones from Artemisia sieberi.
abstract: Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3'-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities.
authors.affiliation: a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt.
authors.forename: Tarik A
authors.identifier: http://orcid.org/0000-0003-1639-3518
authors.initials: TA
authors.lastname: Mohamed
authors.affiliation: a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt.
authors.forename: Mohamed-Elamir F
authors.identifier: http://orcid.org/0000-0002-0343-4969
authors.initials: MF
authors.lastname: Hegazy
authors.affiliation: b Chemistry of Natural and Microbial Products Department , National Research Centre , Giza 12622 , Egypt.
authors.forename: Abeer A
authors.initials: AA
authors.lastname: Abd El Aty
authors.affiliation: c Department of Pharmaceutical Chemistry , College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia.|d Faculty of Pharmacy, Department of Medicinal Chemistry , University of Mansoura , Mansoura 35516 , Egypt.
authors.forename: Hazem A
authors.initials: HA
authors.lastname: Ghabbour
authors.affiliation: e Pharmacognosy Department , College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia.
authors.forename: Mansour S
authors.initials: MS
authors.lastname: Alsaid
authors.affiliation: a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt.|e Pharmacognosy Department , College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia.
authors.forename: Abdelaaty A
authors.identifier: http://orcid.org/0000-0003-0456-3196
authors.initials: AA
authors.lastname: Shahat
authors.affiliation: f Chemistry & Biochemistry Department , Texas Tech University , Lubbock , TX 79409 , USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Paré
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019306:Artemisia / Q000737:chemistry*; D019659:Asteraceae / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: C000625173:1R,8S-dihydroxy-11R,13-dihydrobalchanin; C000625171:3R,8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide; D000900:Anti-Bacterial Agents; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes
keywords: Artemisia sieberi; Asteraceae; Sesquiterpenes; X-rays analysis; antimicrobial activity