title: Polymorphisms of Il-10 (-1082) and RANKL (-438) Genes and the Failure of Dental Implants.
abstract: Background. Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant.Purpose. To investigate the association of genetic polymorphisms in interleukin-(IL-) 10[-1082 region (A/G)] andRANKL[-438 region (A/G)] with the failure of dental implants.Materials and Methods. This study included 90 partially edentulous male and female patients who were rehabilitated with a total of 245 Straumann dental implants. An implant was considered a failure if any of the following occurred: mobility, persistent subjective complaint, recurrent peri-implant infection with suppuration, continuous radiolucency around the implant, probing depth ≥ 5 mm, and bleeding on probing. Buccal mucosal cells were collected for analysis ofRANKL438andIL-10.Results. The implant success rate in this population was 34.4%. The mutant allele (G) inRANKLhad an incidence of 52.3% and mutant allele (A) inIL-10was observed in 37.8%. No statistically significant difference was detected between the failure of the implant and the genotypes and allelic frequencies.Conclusion. No association was detected between the genetic polymorphisms ofRANKL(-438) andIL-10(-1082) and the failure of dental implants in the population studied.
authors.affiliation: Federal University of Campina Grande, Campina Grande, PB, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Ribeiro
authors.affiliation: Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Rayanne
authors.initials: R
authors.lastname: Melo
authors.affiliation: Department of Prosthodontics, University of São Paulo, São Paulo, SP, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Tortamano Neto
authors.affiliation: Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: André
authors.initials: A
authors.lastname: Vajgel
authors.affiliation: Department of Genetics, Rural Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Paulo Roberto Eleutério
authors.identifier: 0000-0002-9186-9849
authors.initials: PR
authors.lastname: Souza
authors.affiliation: Department of Prosthodontics and Oral and Facial Surgery, Federal University of Pernambuco, Recife, PE, Brazil.
authors.forename: Renata
authors.identifier: 0000-0003-3673-8739
authors.initials: R
authors.lastname: Cimões