title: [Regulation of immunity and inflammation by autophagy: « All is well, all is fine, all goes as well as possible»].
abstract: Autophagy is a lysosomal degradation mechanism which helps to control intracellular infections and contributes to the regulation of innate and adaptive immune responses. Defects in autophagy lead to exacerbated proliferation of microorganisms and/or to excessive immune responses which are both highly deleterious. Thus, infectious and chronic inflammatory human diseases, such as Crohn's disease, are often associated with inappropriate modulation of autophagy, which is mainly linked to autophagy-associated gene polymorphisms. In this review, we highlight the current understanding of role of autophagy in infections and immunity.
authors.affiliation: Univ. Bourgogne Franche-Comté, AgroSup Dijon, PAM UMR A 02.102, F-21000 Dijon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lapaquette
authors.affiliation: Université Clermont Auvergne, M2iSH, UMR 1071 Inserm/Université d'Auvergne, Clermont-Ferrand, France.
authors.forename: Hang Thi Thu
authors.initials: HT
authors.lastname: Nguyen
authors.affiliation: CIRI, Centre international de recherche en infectiologie, équipe autophagie infection immunité, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, 21, avenue Tony Garnier, F-69007, Lyon, France.
authors.forename: Mathias
authors.initials: M
authors.lastname: Faure
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D003424:Crohn Disease / Q000276:immunology / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D058847:Inflammasomes / Q000502:physiology; D007249:Inflammation / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D007372:Interferons / Q000502:physiology; D016328:NF-kappa B / Q000502:physiology
chemical_list: D058847:Inflammasomes; D016328:NF-kappa B; D007372:Interferons