title: Increased Antioxidant Quality Versus Lower Quantity of High Density Lipoprotein in Benign Prostatic Hyperplasia.
abstract: BACKGROUND
  Oxidative stress may be involved in the pathogenesis of every human disease. To understand its possible role in benign prostatic hyperplasia (BPH), we measured the overall oxidative status of patients with BPH and the serum activity of the high density lipoprotein (HDL)-related antioxidant enzymes paraoxonase 1 (PON1) and arylesterase (ARE).
  
  
  METHODS
  Fifty-six urology outpatient clinic patients with BPH (mean age 64±8.6 years) were prospectively included in the study. Forty volunteer healthy controls from the laboratory staff (mean age 62±10 years) were enrolled for comparison. Serum total antioxidant status (TAS), total oxidant status (TOS), PON1, ARE, and HDL levels were measured by commercially available, ready-to-use kits.
  
  
  RESULTS
  Serum TAS and HDL levels were significantly lower in the BPH group than in the control group (P=0.004 and P=0.02, respectively). No significant between-group differences were observed for TOS levels or PON1 and ARE enzyme activities (P=0.30, P=0.89, and P=0.74, respectively). In the BPH group, the calculated parameters PON1/HDL and ARE/HDL were significantly higher (P=0.02 and P=0.04, respectively).
  
  
  CONCLUSIONS
  Our findings agree with the previous reports of impaired oxidant/antioxidant balance in BPH patients. The activities of HDL-related enzymes between groups with significantly different HDL levels may be deceptive; adjusted values may help to reach more accurate conclusions.
authors.affiliation: Clinical Biochemistry, Batman Maternity and Children's Hospital of Ministry of Health, Batman, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Aydin
authors.affiliation: Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Hamit Yasar
authors.initials: HY
authors.lastname: Ellidag
authors.affiliation: Clinical Biochemistry, Antalya Public Health Center of Ministry of Health, Antalya, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Eren
authors.affiliation: Clinical Biochemistry, Tatvan Military Hospital, Bitlis, Turkey.
authors.forename: Nurullah
authors.initials: N
authors.lastname: Ay
authors.affiliation: Urology Clinic of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Soner
authors.initials: S
authors.lastname: Yalçınkaya
authors.affiliation: Central Laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Necat
authors.initials: N
authors.lastname: Yilmaz
keywords: HDL functionality; adjusted paraoxonase and arylesterase; metabolic syndrome; oxidative stress; total antioxidant status; total oxidant status