title: Consequences of Transfusing Blood Components in Patients With Trauma: A Conceptual Model.
abstract: Transfusion of blood components is often required in resuscitation of patients with major trauma. Packed red blood cells and platelets break down and undergo chemical changes during storage (known as thestorage lesion) that lead to an inflammatory response once the blood components are transfused to patients. Although some evidence supports a detrimental association between transfusion and a patient's outcome, the mechanisms connecting transfusion of stored components to outcomes remain unclear. The purpose of this review is to provide critical care nurses with a conceptual model to facilitate understanding of the relationship between the storage lesion and patients' outcomes after trauma; outcomes related to trauma, hemorrhage, and blood component transfusion are grouped according to those occurring in the short-term (≤30 days) and the long-term (>30 days). Complete understanding of these clinical implications is critical for practitioners in evaluating and treating patients given transfusions after traumatic injury.
authors.affiliation: Allison R. Jones is an assistant professor, Department of Acute, Chronic, and Continuing Care, School of Nursing, University of Alabama, Birmingham, Alabama. She has a clinical background in emergency and trauma nursing. In research, she focuses on the consequences of blood component storage and transfusion, with particular interest in transfusion after trauma. allisonjones3684@gmail.com.|Susan K. Frazier is the director of the PhD program, a codirector of the RICH Heart Program, and an associate professor, College of Nursing, University of Kentucky, Lexington, Kentucky. Her research focuses on cardiopulmonary interactions in a variety of critically ill patients, including patients with acute heart failure, acute decompensated heart failure, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and multiple trauma. allisonjones3684@gmail.com.
authors.forename: Allison R
authors.initials: AR
authors.lastname: Jones
authors.affiliation: Allison R. Jones is an assistant professor, Department of Acute, Chronic, and Continuing Care, School of Nursing, University of Alabama, Birmingham, Alabama. She has a clinical background in emergency and trauma nursing. In research, she focuses on the consequences of blood component storage and transfusion, with particular interest in transfusion after trauma.|Susan K. Frazier is the director of the PhD program, a codirector of the RICH Heart Program, and an associate professor, College of Nursing, University of Kentucky, Lexington, Kentucky. Her research focuses on cardiopulmonary interactions in a variety of critically ill patients, including patients with acute heart failure, acute decompensated heart failure, acute respiratory distress syndrome, chronic obstructive pulmonary disease, and multiple trauma.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Frazier
mesh_terms: D016913:Blood Component Transfusion / Q000009:adverse effects* / Q000592:standards*; D001793:Blood Preservation / Q000592:standards*; D064648:Critical Care Nursing / Q000592:standards*; D005260:Female; D006470:Hemorrhage / Q000628:therapy*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000628:therapy*; D008297:Male; D017410:Practice Guidelines as Topic; D013997:Time Factors; D014947:Wounds and Injuries / Q000628:therapy*