title: Association betweenHelicobacter pyloriinfection and angiographically demonstrated coronary artery disease: A meta-analysis.
abstract: Coronary artery disease (CAD) is a leading cause of mortality globally. However, the etiology and pathogenesis of CAD are not fully understood. The aim of the present meta-analysis was to estimate the association between the risk of CAD andHelicobacter pylori(H. pylori) infection. A literature search was performed to identify eligible studies published prior to August 14, 2014. Fixed or random effect meta-analytical methods were used to pool the data and perform the subgroup analyses. The effect measures estimated were the odds ratios (OR) for dichotomous data reported with 95% confidence intervals (95% CI). Of the 109 studies identified using the search parameters, 26 cross-sectional studies were eligible involving 3,901 CAD patients and 2,751 controls.H. pyloriinfection was associated with an increased risk of CAD (OR: 1.96, 95% CI: 1.47-2.63, P<0.00001). When the adjusted ORs were used to conduct another meta-analysis, the OR value decreased, but the association remained significant (OR: 1.42, 95% CI: 1.09-1.86, P=0.008). The association betweenH. pyloriinfection and CAD risk was stronger in younger individuals than in older individuals (OR: 2.36, 95% CI 1.50-3.73 vs. OR: 1.59, 95% CI: 1.19-2.11). A significant association was observed in studies from Europe (OR: 2.11, 95% CI: 1.54-2.88, P=0.01) and the USA (OR: 1.43, 95% CI: 1.08-1.91, P=0.36). There is a potential association betweenH. pyloriinfection and the risk of CAD. The association may be influenced by age and ethnicity.
authors.affiliation: Central Laboratories, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China.
authors.forename: Xin-Juan
authors.initials: XJ
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Radiology, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.affiliation: Central Laboratories, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Central Laboratories, Qingdao Municipal Hospital, Qingdao, Shandong 266000, P.R. China.
authors.forename: Quan-Jiang
authors.initials: QJ
authors.lastname: Dong
keywords: Helicobacter pylori; coronary artery disease; meta-analysis; subgroup analysis