title: Importance of Inherent Substrate Reactivity in Enzyme-Promoted Carbocation Cyclization/Rearrangements.
abstract: The importance of inherent substrate reactivity for terpene synthase enzymes is discussed, with a focus on recent experimental tests of predictions derived from computations on gas-phase reactivity of carbocations.
authors.affiliation: Department of Chemistry, University of California-Davis, 1 Shields Avenue, Davis, CA, 95616, USA.
authors.forename: Dean J
authors.initials: DJ
authors.lastname: Tantillo
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000378:metabolism*; D002412:Cations; D003500:Cyclization; D007554:Isotopes / Q000378:metabolism; D008956:Models, Chemical; D013379:Substrate Specificity; D013729:Terpenes / Q000378:metabolism
chemical_list: D002412:Cations; D007554:Isotopes; D013729:Terpenes; D019883:Alkyl and Aryl Transferases; C108877:terpene synthase
keywords: carbocations; enzymes; inherent reactivity; intrinsic reactivity; terpenes