title: Protective Effect of Tang Wang One Decoction on the Retinal Vessels of Diabetic Rats.
abstract: Objective. This study aimed to determine the influence of Tang Wang One Decoction (TWOD) on the retinal vessels of diabetic rats.Methods. The hemorheology of diabetic rats was observed. Morphological studies of retinal vessels were conducted using optical microscopy and electron microscopy. Immunological histochemistry assay was used to measure the expression levels of MMP-9, occludin, and claudin-5.Results. Obvious pathological damage was observed in the retinal vessels of diabetic rats. TWOD positively affected the hemorheology and morphology of retinal vessels. The decoction also decreased the expression of MMP-9 and increased the expression of occludin and claudin-5.Conclusions. The results suggest that the retinal protective effects of TWOD might be related to downregulation of MMP-9 and upregulation of occludin and claudin-5.
authors.affiliation: China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China; Xicheng Maternal and Child Health Hospital, No. 19, Pingyuan Street, Xicheng District, Beijing 100054, China.
authors.forename: Xinyun
authors.initials: X
authors.lastname: Kou
authors.affiliation: China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors.forename: Shufei
authors.initials: S
authors.lastname: Yang
authors.affiliation: China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Qin
authors.affiliation: China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Deng
authors.affiliation: China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
authors.affiliation: China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing 100029, China.
authors.forename: Ming
authors.identifier: 0000-0002-0062-8725
authors.initials: M
authors.lastname: Jin