title: Small Molecules from Deep within the Gut.
abstract: Although the influence of the human microbiome on host functions is widely recognized, the underlying molecular mechanisms are still largely unknown. A recent study by the Fischbach group now provides an experimental workflow for characterizing and evaluating the impact of microbiome-derived small molecules on host physiology.
authors.affiliation: Microbiology, ZMB, Faculty of Biology, University of Duisburg-Essen, Universitätsstrasse 2, 45117, Essen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Ehrmann
authors.affiliation: Chemical Biology, ZMB, Faculty of Biology, University of Duisburg-Essen, Universitätsstrasse 2, 45117, Essen, Germany.
authors.forename: Markus
authors.identifier: 0000-0002-6540-8520
authors.initials: M
authors.lastname: Kaiser
mesh_terms: D006801:Humans; D056186:Metagenomics / Q000379:methods; D064307:Microbiota / Q000502:physiology*; D005810:Multigene Family; D010453:Peptide Synthases / Q000032:analysis / Q000235:genetics; D010829:Physiological Phenomena / Q000502:physiology*; D011480:Protease Inhibitors
chemical_list: D011480:Protease Inhibitors; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase
keywords: biosynthesis; metagenomics; microbiome; natural products; protease inhibitors