title: Increased abundance of myeloid-derived suppressor cells and Th17 cells in peripheral blood of newly-diagnosed Parkinson's disease patients.
abstract: Parkinson's disease (PD) is a neurodegenerative disease that is often associated with corresponding neuroinflammation. In the present study, flow cytometry was used to detect T-helper 17 (Th17) cells and myeloid-derived suppressor cells (MDSCs) in 18 patients newly diagnosed with PD as well as 18 normal controls. Results showed that Th17 cells and MDSCs were significantly higher in peripheral blood of PD patients compared to controls (P<0.001). Furthermore, there was no correlation between Th17 cells and MDSCs in peripheral blood of PD patients. Our findings suggest that Th17 cells and MDSCs may be important factors related to the occurrence and progression of PD, as well as the development of PD-related neuroinflammation.
authors.affiliation: Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
authors.forename: Siyuan
authors.initials: S
authors.lastname: Chen
authors.affiliation: The Central Laboratory, the Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
authors.forename: Yueqin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
authors.forename: Yuhao
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
authors.forename: Qianwen
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
authors.forename: Xiujian
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Immunology, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, China. Electronic address: wangjia5698@sina.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China. Electronic address: yuming7251@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Yu
mesh_terms: D000368:Aged; D004660:Encephalitis / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072737:Myeloid-Derived Suppressor Cells / Q000378:metabolism*; D010300:Parkinson Disease / Q000097:blood* / Q000150:complications; D058504:Th17 Cells / Q000378:metabolism*
keywords: Myeloid-derived suppressor cells; Neuroinflammation; Parkinson’s disease; T-helper 17 cells