title: Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China.
abstract: Background. Recent studies indicated that the Serine threonine kinase 11 (STK11), which is a key regulator of the AMP-activated protein kinase (AMPK), plays a crucial role in cardiovascular system. This study aimed to investigate whether genetic variations in the STK11 gene affect the risk of coronary artery disease (CAD) in Chinese type 2 diabetics.Methods. 5 haplotype-tagging single nucleotide polymorphisms (SNPs) were selected, and 288 CAD-positive cases and 159 CAD-negative controls with type 2 diabetes were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.Results. The carriers of minor allele A at rs12977689 had a higher risk of CAD compared to the homozygotes of CC (OR = 1.572, 95% CI = 1.039-2.376,p= 0.035), and the difference was still significant after adjustment for the other known CAD risk factors (OR' = 1.184, 95%  CI' = 1.036-1.353,p' = 0.013).Conclusion. Genetic variability at STK11 locus is associated with CAD risk in type 2 diabetes in the Chinese population.
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Xiaowei
authors.identifier: 0000-0001-9077-2095
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Bai
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Difei
authors.initials: D
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Linjuan
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Ruifen
authors.initials: R
authors.lastname: Deng
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Ding
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Gu
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Guo
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases