title: Effects of Cisplatin-Loaded Niosomal Nanoparticleson BT-20 Human Breast Carcinoma Cells
abstract: Breast cancer is the fifth most common cause of death among women worldwide. Resistance to cisplatin is a main
  challenge in its treatment. Our present aim was to prepare nanoniosomated cisplatin and examine its efficacy in vitro
  using the BT-20 cell line. Niosome nanoparticles containing cisplatin were prepared by reverse-phase evaporation and
  characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), spectrophotometry and MTT
  assay. The size and zeta potential of the nanodrug were estimated as 489.3 ± 23.66 nm and 23.4 ± 2.1 mV, respectively.
  Drug encapsuies confirmed appropriate retention of particles. Nanoparticles also increased the cytotoxic effects of
  cisplatin by 1.5 times compared to the standard drug. Findings of our study suggest that niosome nanoparticles are
  good carriers for cisplatin delivery to breast cancer cells.
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Isfahan. Email:mehrdiba_t@yahoo.com , ebrahimifar67@gmail.com
authors.forename: Leila
authors.initials: L
authors.lastname: Kanaani
authors.forename: Iraj
authors.initials: I
authors.lastname: Javadi
authors.forename: Meysam
authors.initials: M
authors.lastname: Ebrahimifar
authors.forename: Hasan
authors.initials: H
authors.lastname: Ebrahimi Shahmabadi
authors.forename: Azim
authors.initials: A
authors.lastname: Akbarzadeh Khiyav
authors.forename: Torkan
authors.initials: T
authors.lastname: Mehrdiba
keywords: Breast cancer; cisplatin; niosome nanoparticles; MTT; cytotoxicity