title: Invasive listeriosis in a patient with several episodes of antibiotic associated colitis presumably due to Clostridium difficile.
abstract: A 62-year-old man developed a blood stream infection and meningitis due to Listeria monocytogenes, 20 days after an episode of pseudo-membranous colitis. The patient, hospitalized for the first time for transurethral prostatectomy, was readmitted 20 days later with watery diarrhea. Pseudo-membranous colitis was diagnosed and treated successfully, without testing for Clostridium difficile infection (CDI). After 15 more days, the patient developed again diarrhea, fever and confusion. Hospitalized again, blood and cerebrospinal fluid cultures resulted positive for L. monocytogenes. The patient was treated successfully and a diagnosis of recurrent CDI was confirmed following culture and nucleic acid amplification assays both positive for C. difficile. This is the first report of an invasive listeriosis after CDI underlines the importance of taking greater awareness in complicated blood stream infections that may arise after CDI.
authors.affiliation: Department of Infectious Diseases, D. Cotugno Hospital, AORN Dei Colli, Naples, Italy.
authors.forename: Novella
authors.initials: N
authors.lastname: Carannante
authors.affiliation: Department of Infectious Diseases, D. Cotugno Hospital, AORN Dei Colli, Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Pagliano
authors.affiliation: Department of Infectious Diseases, D. Cotugno Hospital, AORN Dei Colli, Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Rossi
authors.affiliation: Department of Infectious Diseases, D. Cotugno Hospital, AORN Dei Colli, Naples, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Attanasio
authors.affiliation: Department of Infectious Diseases, D. Cotugno Hospital, AORN Dei Colli, Naples, Italy.
authors.forename: Carolina
authors.initials: C
authors.lastname: Rescigno
authors.affiliation: Department of Pharmaceutical Sciences-Microbiology, University of Perugia, Perugia, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Corte
authors.affiliation: Department of Infectious Diseases, D. Cotugno Hospital, AORN Dei Colli, Naples, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Tascini
authors.affiliation: Department of Pharmaceutical Sciences-Microbiology, University of Perugia, Perugia, Italy. gianluigi.cardinali@unipg.it.|Department of Chemistry, Biology and Biotechnology, CEMIN, Centre of Excellence on Nanostructured Innovative Materials, University of Perugia, Perugia, Italy. gianluigi.cardinali@unipg.it.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Cardinali
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016360:Clostridioides difficile / Q000187:drug effects*; D003967:Diarrhea / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007558:Italy; D008089:Listeria monocytogenes / Q000302:isolation & purification / Q000502:physiology; D008088:Listeriosis / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Blood stream infections; Clostridium difficile; Listeria monocytogenes