title: High expression of herpesvirus entry mediator (HVEM) in ovarian serous adenocarcinoma tissue.
abstract: OBJECTIVE
  To explore the expression of herpesvirus entry mediator (HVEM) in ovarian serous adenocarcinoma tissues and its relationship with clinicopathological features.
  
  
  METHODS
  Paraffin-embedded specimens from 40 patients with ovarian serous adenocarcinoma who were subjected to surgical treatment were used for the determination of HVEM expression by immunohistochemistry (IHC). Then the relationship between the expression of HVEM and the patient clinicopathological features was analyzed.
  
  
  RESULTS
  There were 29 cases (72.5%) of HVEM/tumor necrosis factor receptor (TNFR)SF14-positive and 11 cases (27.5%) of HVEM/TNFRSF14-negative. The positive rate of HVEM was significantly correlated with TNM staging, lymph node metastasis and recurrence (p<0.05), but not with age, grade of differentiation and distant metastasis (p>0.05).
  
  
  CONCLUSIONS
  HVEM is highly expressed in ovarian serous adenocarcinoma tissues and correlated with the patient clinicopathological features, such as TNM staging, lymph node metastasis and recurrence. HVEM can provide a basis in the search for a new targeting treatment for ovarian serous adenocarcinoma.
authors.affiliation: Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.forename: Lei
authors.initials: L
authors.lastname: Ye
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.forename: Qi-Zhi
authors.initials: QZ
authors.lastname: He
authors.forename: Jian-Long
authors.initials: JL
authors.lastname: Zhu
mesh_terms: D000328:Adult; D000368:Aged; D018284:Cystadenocarcinoma, Serous / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology*; D053240:Receptors, Tumor Necrosis Factor, Member 14 / Q000032:analysis / Q000502:physiology*
chemical_list: D053240:Receptors, Tumor Necrosis Factor, Member 14; C506028:TNFRSF14 protein, human