title: Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis.
abstract: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.
  
  
  
  A retrospective, multicenter, cohort study.
  
  
  
  Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).
  
  
  
  Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy. gabriele.simonini@unifi.it.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence. gabriele.simonini@unifi.it.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Simonini
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bracaglia
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence.
authors.forename: Marco
authors.initials: M
authors.lastname: Cattalini
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence.
authors.forename: Andrea
authors.initials: A
authors.lastname: Taddio
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence.
authors.forename: Alice
authors.initials: A
authors.lastname: Brambilla
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence.
authors.forename: Cinzia
authors.initials: C
authors.lastname: De Libero
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence.
authors.forename: Denise
authors.initials: D
authors.lastname: Pires Marafon
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence.
authors.forename: Roberto
authors.initials: R
authors.lastname: Caputo
authors.affiliation: From the Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; Ophthalmology Unit, Anna Meyer Children's Hospital, Florence; Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome; Pediatric Immunology and Rheumatology Unit, Brescia; Institute of Child Health and Maternal Health IRCCS Burlo Garofolo; University of Trieste, Trieste, Italy.|G. Simonini, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. Bracaglia, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; M. Cattalini, MD, Pediatric Immunology and Rheumatology Unit; A. Taddio, MD, Institute of Child Health and Maternal Health IRCCS Burlo Garofolo, and University of Trieste; A. Brambilla, MD, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence; C. De Libero, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; D. Pires Marafon, MD, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS; R. Caputo, MD, Ophthalmology Unit, Anna Meyer Children's Hospital; R. Cimaz, MD, Associate Professor, Rheumatology Unit, Anna Meyer Children's Hospital-NEUROFARBA Department, University of Florence.
authors.forename: Rolando
authors.initials: R
authors.lastname: Cimaz
mesh_terms: D000293:Adolescent; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy*; D028761:Withholding Treatment
chemical_list: D018501:Antirheumatic Agents
keywords: AUTOIMMUNE CHRONIC UVEITIS; CHILDREN; RELAPSE; THERAPY WITHDRAWAL