title: Can lncRNAs be indicators for the diagnosis of early onset or acute schizophrenia and distinguish major depressive disorder and generalized anxiety disorder?-A cross validation analysis.
abstract: Depression and anxiety are apparent symptoms in the early onset or acute phase of schizophrenia (SZ), which complicate timely diagnosis and treatment. It is imperative to seek an indicator to distinguish schizophrenia from depressive and anxiety disorders. Using lncRNA microarray profiling and RT-PCR, three up-regulated lncRNAs in SZ, six down-regulated lncRNAs in major depressive disorder (MDD), and three up-regulated lncRNAs in generalized anxiety disorder (GAD) had been identified as potential biomarkers. All the lncRNAs were, then, cross-validated in 40 SZ patients, 40 MDD patients, 40 GAD patients, and 40 normal controls. Compared with controls, three up-regulated SZ lncRNAs had a significantly down-regulated expression in GAD, and no remarkable differences existed between MDD and the controls. Additionally, the six down-regulated MDD lncRNAs were expressed in an opposite fashion in SZ, and the expression of the three up-regulated GAD lncRNAs were significantly different between SZ and GAD. These results indicate that the expression patterns of the three up-regulated SZ lncRNAs could not be completely replicated in MDD and GAD, and vice versa. Thus, these three SZ lncRNAs seem to be established as potential indicators for diagnosis of schizophrenia and distinguishing it from MDD and GAD. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Health Care, Changzhou Maternal and Child Health Care Hospital Affiliated With Nanjing Medical University, Changzhou, People's Republic of China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Cui
authors.affiliation: Department of Rehabilitation, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Niu
authors.affiliation: Prevention and Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Lingming
authors.initials: L
authors.lastname: Kong
authors.affiliation: Prevention and Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Mingjun
authors.initials: M
authors.lastname: He
authors.affiliation: Prevention and Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Kunhong
authors.initials: K
authors.lastname: Jiang
authors.affiliation: Department of Neurology, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Shengdong
authors.initials: S
authors.lastname: Chen
authors.affiliation: Clinical Laboratory, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Aifang
authors.initials: A
authors.lastname: Zhong
authors.affiliation: Gopath Diagnostic Laboratory Co. Ltd., No. 801, Changzhou, People's Republic of China.
authors.forename: Wanshuai
authors.initials: W
authors.lastname: Li
authors.affiliation: Gopath Diagnostic Laboratory Co. Ltd., No. 801, Changzhou, People's Republic of China.|Gopath Laboratories LLC, 1351 Barclay Blvd, Buffalo Grove, Illinois.
authors.forename: Jim
authors.initials: J
authors.lastname: Lu
authors.affiliation: Prevention and Treatment Center for Psychological Diseases, No. 102 Hospital of the Chinese People's Liberation Army, Changzhou, People's Republic of China.
authors.forename: Liyi
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000235:genetics; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics
chemical_list: D015415:Biomarkers; D062085:RNA, Long Noncoding
keywords: epigenetics; generalized anxiety disorder; lncRNA; major depressive disorder; schizophrenia