title: [Role of mitophagy in the mitochondrial quality control].
abstract: Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cells. Mitochondrial dysfunctions are implicated in numerous diseases. Therefore, maintenance of a healthy pool of mitochondria is required for cellular function and survival. Mitochondrial quality control is achieved through several mechanisms that act at different levels: proteases and chaperones, the Ubiquitin-Proteasome-System (UPS) and mitophagy. Multiple mitophagy-involved programs operate independently or undergo crosstalk, and require modulated receptor activities at the outer membranes of mitochondria. In mammals, different mitophagy effectors have been characterized such as the receptors NIX, BNIP3, FUNDC1, BCL2L13, cardiolipin and the PINK1/Parkin pathway. Here we discuss the different molecular mechanisms of these mitophagy involved pathways.
authors.affiliation: CNRS, IBGC, UMR5095, 1, rue Camille Saint-Saëns, F-33000 Bordeaux, France - Université de Bordeaux, IBGC, UMR5095, 1, rue Camille Saint-Saëns, F-33000 Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Vigié
authors.affiliation: CNRS, IBGC, UMR5095, 1, rue Camille Saint-Saëns, F-33000 Bordeaux, France - Université de Bordeaux, IBGC, UMR5095, 1, rue Camille Saint-Saëns, F-33000 Bordeaux, France.
authors.forename: Nadine
authors.initials: N
authors.lastname: Camougrand
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D005057:Eukaryotic Cells / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D063306:Mitophagy / Q000502:physiology*; D011786:Quality Control; D044767:Ubiquitin-Protein Ligases / Q000502:physiology
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein