title: Emerging Role of CaV1.2 Channels in Proliferation and Migration in Distinct Cancer Cell Lines.
abstract: Extensive research is currently underway, seeking better diagnostic methods and treatments and a better understanding of the molecular mechanisms involved in cancer, from the role of specific genetic mutations to the intricate biochemical and molecular pathways involved. Because of their role in regulating relevant physiological events such as cell proliferation, migration, and invasion, ion channels have recently been recognized as important elements in cancer initiation and progression. Moreover, it has been reported that pharmacological intervention in ion channel activity might provide protection against diverse types of cancer, and that ion channels could be used as targets to counteract tumor growth, prevent metastasis, and overcome the therapy resistance of tumor cells. In this context, Ca2+ channels have been found to play a role in tumorigenesis and tumor progression. Specifically, L-type Ca2+ channel inhibition may affect cell proliferation, differentiation, and apoptosis. This review aims to provide insights into the potential role of these channels in cancer cell lines, emphasizing their participation in cell proliferation, migration, and autophagy induction, as well as their potential as rational targets for new cancer therapeutics.
authors.affiliation: Laboratorio de Genómica de Enfermedades Cardiovasculares, Consejo Nacional de Ciencia y Tecnología (CONACYT)-Instituto Nacional de Medicina Genómica, Mexico City, Mexico.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Martínez-Delgado
authors.forename: Ricardo
authors.initials: R
authors.lastname: Felix
mesh_terms: D001343:Autophagy; D020746:Calcium Channels, L-Type / Q000235:genetics / Q000378:metabolism*; D020013:Calcium Signaling / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*
chemical_list: D020746:Calcium Channels, L-Type
keywords: Autophagy; Ca2+ channels; CaV1.2 channels; Cancer; Cell proliferation