title: Cell-autonomous mechanisms of chronological aging in the yeastSaccharomyces cerevisiae.
abstract: A body of evidence supports the view that the signaling pathways governing cellular aging - as well as mechanisms of their modulation by longevity-extending genetic, dietary and pharmacological interventions - are conserved across species. The scope of this review is to critically analyze recent advances in our understanding of cell-autonomous mechanisms of chronological aging in the budding yeastSaccharomyces cerevisiae. Based on our analysis, we propose a concept of a biomolecular network underlying the chronology of cellular aging in yeast. The concept posits that such network progresses through a series of lifespan checkpoints. At each of these checkpoints, the intracellular concentrations of some key intermediates and products of certain metabolic pathways - as well as the rates of coordinated flow of such metabolites within an intricate network of intercompartmental communications - are monitored by some checkpoint-specific "master regulator" proteins. The concept envisions that a synergistic action of these master regulator proteins at certain early-life and late-life checkpoints modulates the rates and efficiencies of progression of such processes as cell metabolism, growth, proliferation, stress resistance, macromolecular homeostasis, survival and death. The concept predicts that, by modulating these vital cellular processes throughout lifespan (i.e., prior to an arrest of cell growth and division, and following such arrest), the checkpoint-specific master regulator proteins orchestrate the development and maintenance of a pro- or anti-aging cellular pattern and, thus, define longevity of chronologically aging yeast.
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Anthony
authors.initials: A
authors.lastname: Arlia-Ciommo
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Anna
authors.initials: A
authors.lastname: Leonov
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Amanda
authors.initials: A
authors.lastname: Piano
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Veronika
authors.initials: V
authors.lastname: Svistkova
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Vladimir I
authors.initials: VI
authors.lastname: Titorenko
keywords: carbohydrate metabolism; cell-autonomous mechanisms of longevity regulation; lipid metabolism; mitochondria; proteostasis; systems biology of cellular aging; yeast chronological aging