title: A comparison of the material properties of natural and synthetic vascular walls.
abstract: Characterization of the mechanical properties of native and synthetic vascular grafts is an essential task in the process of designing novel vascular constructs. The aim in this study was to compare the mechanical behavior of ovine left Subclavian artery with that of POSS-PCU (a commercial biomaterial which is currently under clinical investigation. ClinicalTrials.gov Identifier: NCT02301312). We used Delfino's strain energy potential within the framework of quasilinear viscoelasticity theory to capture the viscoelastic response of the considered materials. The material parameters of the quasilinear viscoelastic constitutive equation were determined through a combination of experimental and computational method. First, a uniaxial tensile testing device was used to perform a series of stress relaxation tests on ring samples. Then, the derived quasilinear viscoelastic models were implemented into finite element system. With the aid of mechanical experimentation and finite element simulation, the material parameters were obtained, modified and used for comparison of the mechanical properties of vascular walls. The results showed that the stiffness and the long term viscoelastic parameters of POSS-PCU may lead to different stress responses of the vascular walls. These two factors can be improved by modifications in manufacturing parameters of the synthetic vessel.
authors.affiliation: Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Ave, Tehran, Iran.
authors.forename: Forough
authors.initials: F
authors.lastname: Askari
authors.affiliation: Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Ave, Tehran, Iran. Electronic address: shafieian@aut.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Shafieian
authors.affiliation: Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Ave, Tehran, Iran.
authors.forename: Atefeh
authors.initials: A
authors.lastname: Solouk
authors.affiliation: Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Ave, Tehran, Iran.
authors.forename: Ata
authors.initials: A
authors.lastname: Hashemi
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D001672:Biocompatible Materials / Q000032:analysis*; D004548:Elasticity; D006801:Humans; D008954:Models, Biological; D019736:Prostheses and Implants; D012756:Sheep; D013314:Stress, Mechanical; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials
keywords: Constitutive equation; Finite element model; Hyperelastic properties; Mechanical properties; Quasilinear viscoelasticity; Vascular grafts