title: Regulation of memory B and plasma cell differentiation.
abstract: Memory B cell generation and antibody production result from a differentiation process that begins when the surface BCR on naïve B cells binds an antigen. How the choice between these fates is tempo-spatially regulated is still obscure, but recent advances have reinforced the concept that the combination of B cell-intrinsic heterogeneity and -extrinsic heterogeneity provided by cells such as T cells is a key determinant. As molecular regulators, the transcription factors IRF4 and Bach2, which participate in these fate choices, have been emerging.
authors.affiliation: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, and Graduate School of Frontier Biosciences, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Shinnakasu
authors.affiliation: Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, and Graduate School of Frontier Biosciences, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan; Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. Electronic address: kurosaki@ifrec.osaka-u.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kurosaki
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D050835:Interferon Regulatory Factors / Q000276:immunology; D010950:Plasma Cells / Q000166:cytology / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D000099218:Interferon Regulatory Factor-4
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D050835:Interferon Regulatory Factors; D011947:Receptors, Antigen, B-Cell; D000099218:Interferon Regulatory Factor-4; C491123:BACH2 protein, human