title: [Interstitial processes of the lungs in childhood].
abstract: Interstitial processes in the lungs of children can be due to several underlying diseases. Knowledge of the child's age is important as genetic aberrations play a major role in diseases in the first 2 years, whereas immunological diseases are more common starting in kindergarden age. In general lung diseases are rare in children, which makes the diagnostics difficult and results in a delayed diagnosis. In addition, pediatric pulmonologists are often very reluctant to perform lung biopsies due to a lack of a specialized pathologist. In order to make a contribution to the diagnostics of pediatric pulmonary diseases, pathologists should be specialized in pulmonary pathology, have a good knowledge of genetic methods and fetal lung development, which includes the genetic factors involved in lung growth and differentiation. A close cooperation with the pediatric pulmonologist is necessary and each patient should be discussed jointly on an interstitial lung disease board to promote the quality of diagnostics. The pathologist should be aware that the developing lungs of children are not just a smaller form of adult lungs and often react very differently. In this article, we mainly focus on diffuse infiltration patterns, such as ground glass and reticulonodular infiltrations as described in high-resolution computed tomography (HRCT). Localized interstitial processes, which can sometimes be tumor-like and malformations are not dealt with; however, vascular malformations are included as these often manifest as diffuse interstitial infiltrations and must therefore be taken into consideration for the differential diagnostics.
authors.affiliation: Forschungseinheit für molekulare Lungen- und Pleurapathologie, Institut für Pathologie, Medizinische Universität Graz, Auenbruggerplatz 25, 8036, Graz, Österreich. helmut.popper@medunigraz.at.
authors.forename: H
authors.initials: H
authors.lastname: Popper
mesh_terms: D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D011663:Pulmonary Surfactants / Q000378:metabolism; D012307:Risk Factors; D013038:Specialization; D013577:Syndrome; D014057:Tomography, X-Ray Computed
chemical_list: D011663:Pulmonary Surfactants
keywords: Diffuse infiltrations; Genetic alterations; Immunological diseases; Infections; Vascular malformations