title: Perfusion computed tomography imaging of abdominal aortic aneurysms may be of value for patient specific rupture risk estimation.
abstract: Abdominal aortic aneurysm (AAA) continues to pose a significant cause of unexpected mortality in the developed countries with its incidence constantly rising. The indication of elective surgical repair is currently based on the maximum diameter and growth rate criteria which represent an oversimplification of the Law of Laplace stating that the stress exerted in a cylinder or sphere is proportional to its radius. These criteria fail to capture the complex pathophysiology of the aneurismal disease thus often leading to therapeutic inaccuracies (treating large AAAs with a very low actual rupture risk while observing smaller ones with a much greater risk). Aneurysmal disease is mainly a degenerative process leading to loss of structural integrity of the diseased aortic wall which cannot withhold the stresses due to systemic pressurization. Moreover aortic wall degeneration has been shown to be a localized phenomenon and rupture depends on the pointwise comparison of strength and stress rather than a global aortic wall weakening. Ex-vivo mechanical studies have related vessel wall hypoxia to loss of structural endurance and reduced wall strength. Therefore a module to capture in vivo variation of aortic wall blood supply and oxygenation would be of value for the evaluation of AAA rupture risk. Perfusion computed tomography (PCT) imaging represents a novel technique which has been already used to estimate tissue vascularity in several clinical conditions but not aneurismal disease. We hypothesize that PCT could be used as an adjunct tool during AAA diagnostics in order to evaluate aortic wall oxygenation in vivo, therefore providing a possible means to identify weak spots making the lesion amenable to rupture.
authors.affiliation: Vascular Surgery Unit, Department of Cardiothoracic and Vascular Surgery, University of Crete Medical School, 71110 Heraklion, Crete, Greece. Electronic address: kontopodisn@yahoo.gr.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kontopodis
authors.affiliation: Interventional Radiology Unit, Radiology Department, University of Crete Medical School, 71110 Heraklion, Crete, Greece. Electronic address: nikos_meduoc@hotmail.com.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Galanakis
authors.affiliation: Interventional Radiology Unit, Radiology Department, University of Crete Medical School, 71110 Heraklion, Crete, Greece. Electronic address: tsetis@med.uoc.gr.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Tsetis
authors.affiliation: Vascular Surgery Unit, Department of Cardiothoracic and Vascular Surgery, University of Crete Medical School, 71110 Heraklion, Crete, Greece. Electronic address: ioannou@med.uoc.gr.
authors.forename: Christos V
authors.initials: CV
authors.lastname: Ioannou
mesh_terms: D001011:Aorta / Q000503:physiopathology; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging*; D001019:Aortic Rupture / Q000000981:diagnostic imaging*; D001696:Biomechanical Phenomena; D003198:Computer Simulation; D006801:Humans; D008962:Models, Theoretical; D010477:Perfusion; D018570:Risk Assessment; D012307:Risk Factors; D013314:Stress, Mechanical; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014466:Ultraviolet Rays
keywords: Aneurysm rupture risk; Aortic imaging; Aortic wall strength