title: Syndrome of inappropriate antidiuretic hormone secretion induced by the phytotherapy Harpagophytum procumbers: case report.
abstract: BACKGROUND
  The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the inability of antidiuretic hormone (ADH) suppression, compromising the mechanisms of water excretion and urinary concentration. It manifests as hyponatremia and its symptoms, especially neurological. There are many causes that trigger such disease, notably: central nervous system disorders, malignant neoplasm, drugs and others.
  
  
  METHODS
  A 65 years female hypertensive patient presented clinical and laboratory manifestations of hyponatremia due to SIADH. It happened twice under use of herbal medication for osteoarthritis treatment.
  
  
  CONCLUSIONS
  The drug-related hyponatremia can be triggered by direct effect of the drug or by association with SIADH. The clinical manifestations presented could have been related to psychiatric condition and may have severe outcome if not properly diagnosed. The association of an herbal medicine to SIADH could be confirmed after a new episode of hyponatremia related to Harpagophytum procumbers reintroduction. Our literature review did not find this herbal medicine associated with SIADH, so far.
  
  
  CONCLUSIONS
  SIADH may be caused by herbal medicine described from now on their association in the literature.
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Brazil.
authors.forename: Renata Reis
authors.initials: RR
authors.lastname: Carvalho
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Brazil.
authors.forename: Camila Dermínio
authors.initials: CD
authors.lastname: Donadel
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Brazil.
authors.forename: Arthur Fernandes
authors.initials: AF
authors.lastname: Cortez
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Brazil.
authors.forename: Vitor Ribeiro Gomes de Almeida
authors.initials: VR
authors.lastname: Valviesse
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Brazil.
authors.forename: Pedro Felipe de Almeida
authors.initials: PF
authors.lastname: Vianna
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Brazil.
authors.forename: Bruno Bordallo
authors.initials: BB
authors.lastname: Corrêa
mesh_terms: D005260:Female; D031684:Harpagophytum; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D008875:Middle Aged; D008517:Phytotherapy / Q000009:adverse effects*; D028321:Plant Preparations / Q000009:adverse effects*
chemical_list: D028321:Plant Preparations