title: The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients.
abstract: BACKGROUND
  The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN).
  
  
  METHODS
  A retrospective cohort study including 86 adult IgAN patients was conducted. The Oxford Classification and the JHC were evaluated by 7 independent specialists. The JHC, MEST score in the Oxford Classification, and crescents were analyzed in association with renal outcome, defined as a 50% increase in serum creatinine.
  
  
  RESULTS
  In multivariate analysis without the JHC, only the T score was significantly associated with renal outcome. While, a significant association was revealed only in the JHC on multivariate analysis with JHC.
  
  
  CONCLUSIONS
  The JHC and T score in the Oxford Classification were associated with renal outcome among Japanese patients with IgAN. Superiority of the JHC as a predictive index should be validated with larger study population and cohort studies in different ethnicities.
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Ahmad Baseer
authors.initials: AB
authors.lastname: Kaihan
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan. yyasuda@med.nagoya-u.ac.jp.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Yasuda
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Katsuno
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Kato
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Imaizumi
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Takaya
authors.initials: T
authors.lastname: Ozeki
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hishida
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Nagata
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ando
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Naotake
authors.initials: N
authors.lastname: Tsuboi
authors.affiliation: Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007668:Kidney / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
keywords: ESRD; IgA nephropathy; Japanese Histologic Classification; Oxford Classification; Renal pathology