title: Adult-onset hypophosphatemic osteomalacia associated with Sjogren syndrome: Clinical case report.
abstract: BACKGROUND
  Hypophosphatemic osteomalacia (HO) is a metabolic bone disease, exhibiting different etiologies such as genetic mutation, tumor induction, dysimmunity, or renal disease. Sjogren's syndrome (SS) is a connective tissue disorder commonly involving exocrine glands; however kidney involvement is also encountered, leading to abnormal phosphorus metabolism, even HO.
  
  
  METHODS
  A 47-year-old female patient presented progressively worsening pain in the chest wall, back and bilateral lower extremities as well as muscle weakness was referred to our department.
  
  
  METHODS
  Due to the laboratory test results, radiographic findings and pathologic results, she was diagnosed with adult-onset HO associated with SS. She was then treated with alkalinization, steroids, neutral phosphate, calcium supplements together with activated vitamin D. So far, she recovered uneventfully with relieved pain and increased serum phosphorus level.
  
  
  CONCLUSIONS
  HO may be secondary to renal tubular acidosis of SS patients, and it might be a diagnostic challenge when the kidney involvement in SS is latent and precede the typical sicca symptoms.
authors.affiliation: Department of Nuclear Medicine, West China Hospital of Sichuan University Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Shen
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shuang
authors.initials: S
authors.lastname: Hu
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Anren
authors.initials: A
authors.lastname: Kuang
mesh_terms: D005260:Female; D006801:Humans; D017674:Hypophosphatemia / Q000000981:diagnostic imaging / Q000209:etiology*; D008875:Middle Aged; D010018:Osteomalacia / Q000000981:diagnostic imaging / Q000209:etiology*; D049268:Positron-Emission Tomography; D012859:Sjogren's Syndrome / Q000150:complications* / Q000000981:diagnostic imaging