title: Critical role of environmental factors in the pathogenesis of psoriasis.
abstract: Psoriasis is a common cutaneous disease with multifactorial etiology including genetic and non-genetic factors, such as drugs, smoking, drinking, diet, infection and mental stress. Now, the role of the interaction between environmental factors and genetics are considered to be a main factor in the pathogenesis of psoriasis. However, it is a challenge to explore the mechanisms how the environmental factors break the body balance to affect the onset and development of psoriasis. In this article, we review the pathogenesis of psoriasis and summarize numerous clinical data to reveal the association between environmental factors and psoriasis. In addition, we focus on the mechanisms of environmental risk factors impact on psoriasis and provide a series of potential treatments against environmental risk factors.
authors.affiliation: Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Jinrong
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Shuaihantian
authors.initials: S
authors.lastname: Luo
authors.affiliation: Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Yumeng
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, Second Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Lu
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects / Q000276:immunology; D003141:Communicable Diseases / Q000150:complications / Q000276:immunology; D004781:Environmental Exposure / Q000009:adverse effects*; D044127:Epigenesis, Genetic / Q000235:genetics*; D000069196:Gastrointestinal Microbiome / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000276:immunology; D011565:Psoriasis / Q000209:etiology* / Q000628:therapy*; D012307:Risk Factors; D012867:Skin / Q000276:immunology / Q000382:microbiology; D012907:Smoking / Q000009:adverse effects / Q000276:immunology; D013315:Stress, Psychological / Q000150:complications / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D016898:Interferon-alpha; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha
keywords: environmental factors; epigenetics; genetics; pathogenesis; psoriasis