title: Successful treatment of Rosai-Dorfman disease usingin situphotoimmunotherapy.
abstract: Rosai-Dorfman disease is difficult to cure. In situ photoimmunotherapy combines local photothermal therapy with immunoadjuvant. In the present case report, a 39-year-old Chinese man with Rosai-Dorfman disease lesions below the left nostril and left preauricular region was treated with in situ photoimmunotherapy. The patient was treated with daily application of topical imiquimod (5%) and laser irradiations every 2 weeks for 8 weeks. After three cycles of treatment, the lesions improved markedly without adverse effects. Our results showed that in situ photoimmunotherapy can be used as an effective treatment for Rosai-Dorfman disease.
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Luo
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Fuhe
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Uma
authors.initials: U
authors.lastname: Keyal
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Bhatta
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China; Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK, USA.
authors.forename: Wei R
authors.initials: WR
authors.lastname: Chen
authors.affiliation: Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, P. R. China.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome