title: Doxorubicin Loaded Chitosan-W18O49Hybrid Nanoparticles for Combined Photothermal-Chemotherapy.
abstract: Combined treatment is more effective than single treatment against most forms of cancer. In this work, doxorubicin loaded chitosan-W18O49nanoparticles combined with the photothermal therapy and chemotherapy are fabricated through the electrostatic interaction between positively charged chitosan and negatively charged W18O49nanoparticles. The in vitro and in vivo behaviors of these nanoparticles are examined by dynamic light scattering, transmission electron microscopy, cytotoxicity, near-infrared fluorescence imaging, and tumor growth inhibition experiment. These nanoparticles have a mean size around 110 nm and show a pH sensitive drug release behavior. After irradiation by the 980 nm laser, these nanoparticles show more pronounced cytotoxicity against HeLa cells than that of free doxorubicin or photothermal therapy alone. The in vivo experiments confirm that their antitumor ability is significantly improved, resulting in superior efficiency in impeding tumor growth and extension of the lifetime of mice.
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.
authors.forename: Shanmei
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.
authors.forename: Jisong
authors.initials: J
authors.lastname: Hua
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.|State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210093, China.
authors.forename: Yinyin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210093, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Institute of Materials Engineering, National Laboratory of Solid State Microstructure, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*
chemical_list: D004365:Drugs, Chinese Herbal; C120250:choto-san; D004317:Doxorubicin
keywords: chemotherapy; chitosan; nanoparticles; photothermal therapy; tungsten oxide