title: Association of cytokines polymorphisms with chronic peridontitis and rheumatoid arthritis in a Mexican population.
abstract: OBJECTIVE
  Historically, it has been shown that rheumatoid arthritis (RA) and periodontitis (PE) share pathophysiological similarities and possibly a genetic background. In order to elucidate the genetic background between both diseases, we evaluated the distributions of five SNPs genotypes and all the possible haplotypes composed in subjects with isolated RA, PE, combined diseases and healthy controls.
  
  
  METHODS
  The study population consisted of 280 Mexican subjects. Genomic DNA was isolated from buccal epithelial cells collected by cheek scrapings and analyzed for the determination of the following SNPs: IL-1α + 4845 (rs17561), IL-1α -889 (rs1800587), IL-1β + 3954 (rs1143634), IL-1β -511(rs16944) and TNF-α -308 (rs1800629).
  
  
  RESULTS
  After adjustment for age, sex and smoking status, multiple logistic regression analysis revealed a no significant association in the genotype frequencies of TNF-α -308 and IL-1α + 4845 SNPs. Otherwise a significant association was observed in IL-1β + 3954 and IL-1β -511 (p < 0.05) while IL-1α -889 was of borderline statistical significance (p = 0.054). Also, we found three negative associated haplotypes with PE: IL-1α + 4845 G/IL-1β -511 A, IL-1β + 3954 C/IL-1β -511 A and interestingly IL-1α -889 C/IL-1β -511 A also with a positive association with RA.
  
  
  CONCLUSIONS
  Some genotypes and haplotypes are associated with the diseases. But it seems that the genetic background of the association between RA and PE needs to be explored deeper.
authors.affiliation: a Doctorado en Ciencias Biomedicas Basicas , Facultad de Medicina, Universidad Autonoma de San Luis Potosi , San Luis Potosi , Mexico.|b Advanced Education in General Dentistry , Master Degree Program at San Luis Potosi University, San Luis Potosi University , San Luis Potosi , Mexico.
authors.forename: Rubén Abraham
authors.initials: RA
authors.lastname: Domínguez-Pérez
authors.affiliation: a Doctorado en Ciencias Biomedicas Basicas , Facultad de Medicina, Universidad Autonoma de San Luis Potosi , San Luis Potosi , Mexico.|b Advanced Education in General Dentistry , Master Degree Program at San Luis Potosi University, San Luis Potosi University , San Luis Potosi , Mexico.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Loyola-Rodriguez
authors.affiliation: c Regional Unit of Rheumathology and Osteoporosis at Central Hospital "Dr. Ignacio Morones Prieto", Faculty of Medicine , San Luis Potosi University , San Luis Potosi , Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Abud-Mendoza
authors.affiliation: d Potosino Institute of Scientific and Technological Research , San Luis Potosí , Mexico.
authors.forename: Angel Gabriel
authors.initials: AG
authors.lastname: Alpuche-Solis
authors.affiliation: a Doctorado en Ciencias Biomedicas Basicas , Facultad de Medicina, Universidad Autonoma de San Luis Potosi , San Luis Potosi , Mexico.|b Advanced Education in General Dentistry , Master Degree Program at San Luis Potosi University, San Luis Potosi University , San Luis Potosi , Mexico.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ayala-Herrera
authors.affiliation: a Doctorado en Ciencias Biomedicas Basicas , Facultad de Medicina, Universidad Autonoma de San Luis Potosi , San Luis Potosi , Mexico.|b Advanced Education in General Dentistry , Master Degree Program at San Luis Potosi University, San Luis Potosi University , San Luis Potosi , Mexico.
authors.forename: Rita Elizabeth
authors.initials: RE
authors.lastname: Martínez-Martínez
mesh_terms: D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000235:genetics*; D016207:Cytokines / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D016207:Cytokines; C508584:IL1A protein, human; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha
keywords: Cytokine SNPs; genetics; haplotypes