title: Analysis of the 19 Y-STR and 16 X-STR loci system in the Han population of Shandong province, China.
abstract: The sex-linked short tandem repeats (STR), Y-STR and X-STR, are important for autosomal STRs in forensic paternity testing. We evaluated the forensic parameters of 19 Y-STRs and 16 X-STRs in the Han population of Shandong province, China. A Goldeneye 20Y kit (DYS391, DYS389I, DYS390, DYS389II, DYS348, DYS456, Y-GATA-H4, DYS447, DYS19, DYS392, DYS393, DYS388, DYS439, DYS635, DYS448, DYS460, DYS458, DYS437, DYS385 a/b) was used to analyze the forensic parameters of 534 unrelated males. A Goldeneye17X system (DXS6795, DXS9902, DXS8378, HPRTB, GATA165B12, DXS7132, DXS7424, DXS6807, DXS6803, GATA172D05, DXS6800, DXS10134, GATA31E08, DXS10159, DXS6789, DXS6810, amelogenin) was used to analyze 97 unrelated males and 214 females. In addition, we used the kits to examine 5 cases with abnormal amelogenin test results, as well as a male child with agenosomia typed by autosomal STR. We found 203 Y-STR haplotypes with allele frequencies ranging from 0.0019 to 0.7959, and GD ranging from 0.3429 to 0.9667. Expect in DXS6803, the allele frequencies of the other 15 X-STR loci showed no differences between females and males. PDFranged from 0.5504 to 0.9638, while PDMranged from 0.3176 to 0.8377. With the exception of DXS6803 and DXS6810, the allele frequencies of other X-STR loci were in accordance with Hardy-Weinberg equilibrium in females. One amelogenin negative case was characterized as a deletion of Y-DYS458. This paper provided data regarding the genetic polymorphism of Y-STRs and X-STRs in the Han population, and demonstrated the importance of Y-STR and X-STR in forensic autosomal STR analysis.
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.|Jinan Di'en Legal Expertise Institute of Forensic Medicine of Jinan Central Hospital, Jinan, Shandong, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Gao
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.|Jinan Di'en Legal Expertise Institute of Forensic Medicine of Jinan Central Hospital, Jinan, Shandong, China.
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: S Y
authors.initials: SY
authors.lastname: Han
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.|Jinan Di'en Legal Expertise Institute of Forensic Medicine of Jinan Central Hospital, Jinan, Shandong, China.
authors.forename: S H
authors.initials: SH
authors.lastname: Sun
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.|Jinan Di'en Legal Expertise Institute of Forensic Medicine of Jinan Central Hospital, Jinan, Shandong, China.
authors.forename: D J
authors.initials: DJ
authors.lastname: Xiao
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.|Jinan Di'en Legal Expertise Institute of Forensic Medicine of Jinan Central Hospital, Jinan, Shandong, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Wang
authors.affiliation: Institute of Forensic Sciences, Ministry of Justice, Shanghai, China.
authors.forename: C T
authors.initials: CT
authors.lastname: Li
authors.affiliation: Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China zhangmaoxiujn@126.com.|Jinan Di'en Legal Expertise Institute of Forensic Medicine of Jinan Central Hospital, Jinan, Shandong, China zhangmaoxiujn@126.com.
authors.forename: M X
authors.initials: MX
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D053523:Amelogenin / Q000235:genetics; D044466:Asian People / Q000235:genetics; D002681:China; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics; D005260:Female; D053803:Forensic Genetics / Q000379:methods; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D010334:Paternity; D011110:Polymorphism, Genetic
chemical_list: D053523:Amelogenin