title: Mechanisms of Traditional Chinese Medicine in the Treatment of Mammary Gland Hyperplasia.
abstract: Mammary gland hyperplasia (MGH) occurs with high frequency among middle-aged women and is closely related to breast cancer. The treatment of this disease has become a research hotspot. Many patients with MGH are worried about the potential side effects of the synthetic drugs they are on. Thus, they seek alternative therapy, such as traditional Chinese medicine (TCM). In recent years, along with the Chinese herbs and its active ingredients, TCM compounds have been widely accepted and implemented in the treatment of MGH, whose mechanism hitherto is not completely clear. In this paper, we elaborate the mechanism of TCM in the treatment of MGH from the perspectives of sexual hormone levels, the expression of ER and PR, hemorheology, free radical activity and lipid peroxidation, VEGF and BFGF, cell proliferation activities, anti-apoptosis gene BcL-2, promoting apoptosis gene Bax, ERK, and tumor suppressor gene. In conclusion, TCM appears to be promising for MGH treatment. This paper will provide an overview of the mechanism of TCM in the treatment of MGH. In the near term, a better understanding of TCM will be achieved through comprehensive studies of its molecular mechanism.
authors.affiliation: * Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin, P.R. China.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Li
authors.affiliation: * Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xin
authors.affiliation: † Department of Natural Medicinal Chemistry, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, P.R. China.
authors.forename: Changfu
authors.initials: C
authors.lastname: Wang
authors.affiliation: * Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin, P.R. China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Wang
authors.affiliation: † Department of Natural Medicinal Chemistry, College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, P.R. China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: * Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin, P.R. China.
authors.forename: Haixue
authors.initials: H
authors.lastname: Kuang
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D049109:Cell Proliferation / Q000187:drug effects / Q000235:genetics; D004365:Drugs, Chinese Herbal; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D016147:Genes, Tumor Suppressor / Q000187:drug effects; D006801:Humans; D006965:Hyperplasia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D019394:Ki-67 Antigen; D015227:Lipid Peroxidation / Q000187:drug effects; D020935:MAP Kinase Signaling System; D042361:Mammary Glands, Human / Q000378:metabolism / Q000473:pathology*; D008517:Phytotherapy; D018809:Proliferating Cell Nuclear Antigen; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D005609:Free Radicals; D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2
keywords: Mammary Gland Hyperplasia; Receptor; Review; Sex Hormone; Traditional Chinese Medicine