title: 68Ga-PSMA PET/CT in Osteosarcoma in Fibrous Dysplasia.
abstract: Fibrous dysplasia (FD) is a benign bone lesion with a rare but potential for malignant transformation. Neither Tc-MDP nor F-FDG PET/CT can differentiate between FD and areas of malignant transformation in FD. We described a case of osteosarcoma developing in FD with selective uptake of tracer in malignant transformation areas demonstrated on a Ga-PSMA PET/CT scan. Our case highlights the ability of Ga-PSMA PET/CT to map tumor neoangiogenesis in osteosarcoma arising in FD, which can have potential implications in prognostication, possibility of antiangiogenesis-based therapeutic options, and in response assessment following chemotherapy.
authors.affiliation: From the *KIMS-DDNMRC, KIMS Cancer Centre; and †Department of Medical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Sasikumar
authors.forename: Ajith
authors.initials: A
authors.lastname: Joy
authors.forename: M R A
authors.initials: MRA
authors.lastname: Pillai
authors.forename: Tony M
authors.initials: TM
authors.lastname: Alex
authors.forename: Geetha
authors.initials: G
authors.lastname: Narayanan
mesh_terms: D001859:Bone Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000150:complications*; D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D006801:Humans; D008875:Middle Aged; D009842:Oligopeptides; D012516:Osteosarcoma / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D000072078:Positron Emission Tomography Computed Tomography
chemical_list: D005709:Gallium Isotopes; D005710:Gallium Radioisotopes; D009842:Oligopeptides; C000718244:gallium 68 PSMA-11; D004492:Edetic Acid