title: Gold nanoshell-based betulinic acid liposomes for synergistic chemo-photothermal therapy.
abstract: A novel synthesis approach is first developed to fabricate a multifunctional smart nanodrug delivery system: gold nanoshell-coated betulinic acid liposomes (AuNS-BA-Lips) mediated by a glutathione. The AuNS-BA-Lips exhibited good size distribution (149.4±2.4nm), preferable photothermal conversion ability and synergistic chemo-photothermal therapy. Additionally, the absorption wavelength of AuNS-BA-Lips showed a significantly red-shifted to near infrared (NIR) region, which can strongly absorbed NIR laser and efficiently convert it into localized heat, thus providing controlled drug release and antitumor thermotherapy. Moreover, the nanocarriers excited by NIR light significantly promoted cell uptake compared to those without irradiation, resulting in an enhanced intracellular drug accumulation. Upon NIR irradiation, the AuNS-BA-Lips showed highly efficient antitumor effects on tumor-bearing mice with an inhibition rate of 83.02%, thus demonstrating a remarkable synergistic therapeutic effect of chemotherapy and thermotherapy. Therefore, this work provides new insight into developing a multifunctional antitumor drug.
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, PR China; State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, PR China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, PR China.
authors.forename: Xuwu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, PR China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, PR China.
authors.forename: Longgang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, PR China.
authors.forename: Liyao
authors.initials: L
authors.lastname: Luo
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, PR China; Hebei Province Asparagus Industry Technology Research Institute, Qinhuangdao, PR China.
authors.forename: Meili
authors.initials: M
authors.lastname: Wang
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, PR China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, PR China; State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao, PR China. Electronic address: dwgao@ysu.edu.cn.
authors.forename: Dawei
authors.initials: D
authors.lastname: Gao
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004358:Drug Therapy / Q000379:methods*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D057145:Nanoshells / Q000627:therapeutic use*; D012516:Osteosarcoma / Q000473:pathology / Q000628:therapy; D053978:Pentacyclic Triterpenes; D010789:Phototherapy / Q000379:methods*; D014315:Triterpenes / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured; D000094062:Betulinic Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D008081:Liposomes; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D006046:Gold; D000094062:Betulinic Acid
keywords: Antitumor; Betulinic acid; Controlled release; Gold nanoshell liposome; Photothermal therapy