title: Cognitive Event-Related Potential, an Early Diagnosis Biomarker in Frail Elderly Subjects: The ERP-MAPT-PLUS Ancillary Study.
abstract: By analyzing brain synaptic function, cognitive event-related potentials (ERPs) could provide powerful and innovative tools for early Alzheimer's disease (AD) diagnosis.
  
  
  
  We investigated the relevance of the ERP-P300 component as a potential diagnosis marker in elderly subjects at risk of developing AD.
  
  
  
  ERP-P300 was analyzed on 85 subjects recruited from the Multidomain Alzheimer Preventive Trial (MAPT). PET-AV45 brain imaging was available from 36 subjects.
  
  
  
  Two ERP-P300 subgroups were identified according to their PET-AV45 status: PET-Aβ positive (n = 15) and PET-Aβ negative (n = 21). In the amyloid positive group, we observed a highly significant increase in P3b latency in parietal brain regions (p = 0.0052). P3b in parietal regions correctly categorized 69.4% elderly subjects from the P300-PET Aβ positive group. Combined analysis of parietal P3b latencies and category fluency correctly classified 75% subjects from the P300-PET Aβ positive group.
  
  
  
  The P300 ERP presents good predictive measure of brain amyloid load and has the potential to be used as a screening instrument for preclinical AD. The incorporation of P3b latency may be used as an adjunctive tool with neuropsychological assessment (i.e., verbal category fluency) as a specific and sensitive method for preclinical assessment of AD.
authors.affiliation: Memory Research and Resource Center for Alzheimer's Disease, Department of Neurology, University Hospital of Montpellier, Montpellier, France.|Clinical Neurophysiology Unit, Department of Neurology, University Hospital of Montpellier, France.
authors.forename: Karim
authors.initials: K
authors.lastname: Bennys
authors.affiliation: Memory Research and Resource Center for Alzheimer's Disease, Department of Neurology, University Hospital of Montpellier, Montpellier, France.|INSERM U1183, University of Montpellier, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Gabelle
authors.affiliation: INSERM U1061, University of Montpellier, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
authors.affiliation: Department of Nuclear Medicine, Gui de Chauliac University Hospital, Montpellier, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: De Verbizier
authors.affiliation: Gérontopôle, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France.|INSERM UMR 1027, Toulouse, France.|University of Toulouse III, Toulouse, France.|Department of Epidemiology and Public Health, CHU Toulouse, Toulouse, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Andrieu
authors.affiliation: Gérontopôle, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France.|INSERM UMR 1027, Toulouse, France.|University of Toulouse III, Toulouse, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vellas
authors.affiliation: Memory Research and Resource Center for Alzheimer's Disease, Department of Neurology, University Hospital of Montpellier, Montpellier, France.|INSERM U1061, University of Montpellier, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Touchon
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000517:prevention & control; D016229:Amyloid beta-Peptides / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D012372:ROC Curve; D011930:Reaction Time / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides
keywords: Alzheimer’s disease; P300 event-related potentials; amyloid; biomarkers; frail elderly