title: Benzalkonium Chloride: A Bronchoconstricting Preservative in Continuous Albuterol Nebulizer Solutions.
abstract: For convenience, many pediatric hospitals are preparing solutions for continuous nebulized albuterol using the 0.5% 20-ml multidose albuterol dropper bottle. This product contains benzalkonium chloride (BAC) that, by itself, produces bronchospasm that is dose dependent and cumulative. The bronchoconstrictive effects of BAC are greater in patients with more severe airway obstruction and increased airway responsiveness. Use of BAC-containing albuterol during severe acute asthma exacerbations may antagonize the bronchodilator response to albuterol, prolong treatment, and increase the risk of albuterol-related systemic adverse effects. Such a deleterious effect of BAC is difficult to detect because some patients improve slowly or may even worsen during treatment. We recommend that only preservative-free albuterol products be used.
authors.affiliation: Department of Pediatrics, University of Florida, Gainesville, Florida.
authors.forename: Sreekala
authors.initials: S
authors.lastname: Prabhakaran
authors.affiliation: Department of Pediatrics, University of Florida, Gainesville, Florida.
authors.forename: Mutasim
authors.initials: M
authors.lastname: Abu-Hasan
authors.affiliation: Department of Pediatrics, University of Florida, Gainesville, Florida.|College of Pharmacy, University of Florida, Gainesville, Florida.
authors.forename: Leslie
authors.initials: L
authors.lastname: Hendeles
mesh_terms: D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects*; D001548:Benzalkonium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D016084:Bronchoconstriction / Q000187:drug effects* / Q000502:physiology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009330:Nebulizers and Vaporizers / Q000592:standards; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage / Q000009:adverse effects*; D016032:Randomized Controlled Trials as Topic / Q000379:methods
chemical_list: D001548:Benzalkonium Compounds; D001993:Bronchodilator Agents; D011310:Preservatives, Pharmaceutical; D000420:Albuterol
keywords: albuterol; benzalkonium chloride; drug-induced bronchospasm; paradoxical bronchospasm; preservatives