title: The Effect of Sertraline on the Quality of Life for Children and Adolescents with Anxiety Disorder.
abstract: BACKGROUND
  In this study, we aimed to determine the changes in quality of life of children/adolescents with anxiety disorders during six months of sertraline treatment, to investigate parent-child/adolescent concordance in perception of quality of life and to examine the effect of treatment on children/adolescents.
  
  
  METHODS
  In this study, 30 patients with anxiety disorders according to criteria specified in Diagnostic and Statistical Manual of Mental Disorders, 4th. Edition (DSM-IV) were assigned to sertraline treatment. The patients were evaluated using the Pediatric Quality of Life Inventory (PedsQL), State-Trait Anxiety Inventory for Children, Clinical Global Impression Scale (CGI) and the Children's Global Assessment Scale (CGAS) at 0th, 2ndand 6thmonths.
  
  
  RESULTS
  PedsQL total scores increased significantly with the treatment in children and adolescents (p<.001), however, no differences were observed in parent proxy report (p=.326). The mean CGAS score was 59.85±7.73 at the beginning of treatment and 73.70±7.01 at the end of treatment (p<.001). The average CGI score decreased from 4.68±.96 to 2.27±.84.
  
  
  CONCLUSIONS
  It was observed that perception of quality of life in children and adolescents with anxiety disorders increased with the treatment.
authors.affiliation: Kocaeli University Faculty of Medicine, Child and Adolescent Mental Health and Department of Medicine, Kocaeli, Turkey.
authors.forename: Nursu
authors.initials: N
authors.lastname: Çakin Memik
authors.affiliation: Kocaeli University Faculty of Medicine, Child and Adolescent Mental Health and Department of Medicine, Kocaeli, Turkey.
authors.forename: Işık
authors.initials: I
authors.lastname: Karakaya
authors.affiliation: Kocaeli University Faculty of Medicine, Child and Adolescent Mental Health and Department of Medicine, Kocaeli, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Yildiz
authors.affiliation: Kocaeli University Faculty of Medicine, Child and Adolescent Mental Health and Department of Medicine, Kocaeli, Turkey.
authors.forename: Şahika
authors.initials: Ş
authors.lastname: Şişmanlar
authors.affiliation: Kocaeli University Faculty of Medicine, Department of Public Health, Kocaeli, Turkey.
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Çağlayan
authors.affiliation: Kocaeli University Faculty of Medicine, Child and Adolescent Mental Health and Department of Medicine, Kocaeli, Turkey.
authors.forename: Belma
authors.initials: B
authors.lastname: Ağaoğlu
keywords: Anxiety disorders; adolescents; child; quality of life