title: Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study.
abstract: To purpose of this study was to reveal the mean levels and positive proportion of serological markers related to rheumatoid arthritis, and clarify their relationship with osteoporosis and hand osteoarthritis (OA). A total of 1546 participants from the third survey of the research on osteoarthritis/osteoporosis against disability study were enrolled in the current study. Using participant blood samples, the levels of anti-cyclic citrullinated protein (CCP) antibody, rheumatoid factor (RF), matrix metalloproteinase-3 (MMP-3), C-reactive protein (CRP), and high-sensitivity CRP (hsCRP) were measured. Subjects with higher than normal levels were defined as being positive. Osteoporosis was defined according to the recommendations set by World Health Organization criteria in 1994. Radiographic hand OA was evaluated using the modified Kellgren-Lawrence (KL) scale. The positive proportion of anti-CCP antibody, RF, MMP-3, CRP, and hsCRP was 1.8, 7.1, 15.0, 6.7, and 6.4%, respectively. MMP-3 was associated with age, and was significantly higher in men than in women. Positive MMP-3 was not significantly related to osteoporosis or severe hand OA (KL grade ≥3) after adjustment for other factors including age, sex, and body mass index. The results from this study clarified the values and positive proportion of RA-related markers and revealed their relationship with osteoporosis and hand OA.
authors.affiliation: Department of Orthopedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Kodama
authors.affiliation: Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Muraki
authors.affiliation: Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Iidaka
authors.affiliation: Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oka
authors.affiliation: Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Teraguchi
authors.affiliation: Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Kagotani
authors.affiliation: Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Asai
authors.affiliation: Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashizume
authors.affiliation: Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan.
authors.forename: Munehito
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: Department of Orthopedic Surgery, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.affiliation: National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Akune
authors.affiliation: Department of Orthopedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan. yoshimuran-ort@h.u-tokyo.ac.jp.
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood*; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000097:blood*; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood*; D010024:Osteoporosis / Q000097:blood*; D010456:Peptides, Cyclic / Q000097:blood; D012217:Rheumatoid Factor / Q000097:blood
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D010456:Peptides, Cyclic; D002097:C-Reactive Protein; D012217:Rheumatoid Factor; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3
keywords: Biomarkers; Matrix metalloproteinase-3; Osteoarthritis; Osteoporosis; Rheumatoid arthritis