title: Neuropsychology of subjects with ultra-high risk (UHR) of psychosis: A critical analysis of the literature.
abstract: Cognitive disorders are currently considered as central components of disorders found in schizophrenia and are a major handicap for patients day to day. These disorders appear before the first psychotic episode, in the prodromal phase, during which time the symptoms are below the threshold for psychosis. People with these symptoms are considered as presenting an at-risk mental state (or at ultra-high risk, UHR of psychosis) and their risk for psychotic transition is between 20% and 40% within one year. Despite a number of studies, the chronology in which cognitive disorders appear in relation to the psychotic symptoms has not clearly been established and the study of the links between cognition and symptoms could improve our understanding of psychotic disorders. The detection of certain cognitive disorders before the onset of psychotic disorders could help improve early detection. We carried out a systematic analysis of the literature exploring cognitive disorders found in subjects with UHR for psychosis. The objective of most studies was to establish the predictive value for psychotic transition. Nevertheless study results have shown little consensus. Faced with this heterogeneity of results from past studies, we carried out a critical analysis of the literature and suggest areas of reflection for future research.
authors.affiliation: Service hospitalo-universitaire, CJAAD, centre hospitalier Sainte-Anne, 75014 Paris, France; Faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Inserm, laboratoire de « physiopathologie des maladies psychiatriques », centre de psychiatrie et neurosciences, U894, institut de psychiatrie (GDR3557), 75014 Paris, France; Inserm, laboratoire « mémoire et cognition », centre de psychiatrie et neurosciences, CPN U894, institut de psychiatrie (GDR 3557), 75014 Paris, France. Electronic address: mam-lam-fook@ch-sainte-anne.fr.
authors.forename: C
authors.initials: C
authors.lastname: Mam-Lam-Fook
authors.affiliation: Service hospitalo-universitaire, CJAAD, centre hospitalier Sainte-Anne, 75014 Paris, France; Faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Inserm, laboratoire de « physiopathologie des maladies psychiatriques », centre de psychiatrie et neurosciences, U894, institut de psychiatrie (GDR3557), 75014 Paris, France; Service hospitalo-universitaire, C3RP, centre hospitalier Sainte-Anne, 75014 Paris, France. Electronic address: c.danset-alexandre@ch-sainte-anne.fr.
authors.forename: C
authors.initials: C
authors.lastname: Danset-Alexandre
authors.affiliation: Service hospitalo-universitaire, CJAAD, centre hospitalier Sainte-Anne, 75014 Paris, France; Faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Inserm, laboratoire de « physiopathologie des maladies psychiatriques », centre de psychiatrie et neurosciences, U894, institut de psychiatrie (GDR3557), 75014 Paris, France. Electronic address: pedron@ch-sainte-anne.fr.
authors.forename: L
authors.initials: L
authors.lastname: Pedron
authors.affiliation: Service hospitalo-universitaire, CJAAD, centre hospitalier Sainte-Anne, 75014 Paris, France; Faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Inserm, laboratoire de « physiopathologie des maladies psychiatriques », centre de psychiatrie et neurosciences, U894, institut de psychiatrie (GDR3557), 75014 Paris, France; Service hospitalo-universitaire, C3RP, centre hospitalier Sainte-Anne, 75014 Paris, France. Electronic address: i.amado@ch-sainte-anne.fr.
authors.forename: I
authors.initials: I
authors.lastname: Amado
authors.affiliation: Service hospitalo-universitaire, CJAAD, centre hospitalier Sainte-Anne, 75014 Paris, France; Faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Inserm, laboratoire de « physiopathologie des maladies psychiatriques », centre de psychiatrie et neurosciences, U894, institut de psychiatrie (GDR3557), 75014 Paris, France; Service hospitalo-universitaire, C3RP, centre hospitalier Sainte-Anne, 75014 Paris, France. Electronic address: r.gaillard@ch-sainte-anne.fr.
authors.forename: R
authors.initials: R
authors.lastname: Gaillard
authors.affiliation: Service hospitalo-universitaire, CJAAD, centre hospitalier Sainte-Anne, 75014 Paris, France; Faculté de médecine, université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Inserm, laboratoire de « physiopathologie des maladies psychiatriques », centre de psychiatrie et neurosciences, U894, institut de psychiatrie (GDR3557), 75014 Paris, France; Service hospitalo-universitaire, C3RP, centre hospitalier Sainte-Anne, 75014 Paris, France. Electronic address: mo.krebs@ch-sainte-anne.fr.
authors.forename: M-O
authors.initials: MO
authors.lastname: Krebs
mesh_terms: D003072:Cognition Disorders / Q000209:etiology / Q000523:psychology; D018450:Disease Progression; D042241:Early Diagnosis; D006801:Humans; D009484:Neuropsychology; D062706:Prodromal Symptoms; D011618:Psychotic Disorders / Q000503:physiopathology* / Q000523:psychology*; D012306:Risk
keywords: At-risk; Cognition; Conversion psychotique; Early psychosis; Prodromes; Psychose débutante; Psychotic conversion; Schizophrenia; Schizophrénie; À risque