title: A new proposition for the screening of platelet function defects using an hematology analyzer.
abstract: In this paper we suggest a new method for the screening of congenital thrombopathies using an hematology analyzer. This method is an improvement of the platelet count ratio principle which uses an impedance counter to search a decrease of the free platelet count after adding platelet agonist to whole blood. We suggest using novel platelet parameters provided by an optical hematology analyzer such as ADVIA 2120i (Siemens Healthcare Diagnostics) to search morphological and structural changes of platelet that are supposed reflecting platelet activation in normal platelets after addition of an agonist.
authors.affiliation: Department of Hemobiology, EHU "1er Novembre 1954", Oran, Algeria; Faculty of Medicine of Oran, Algeria. Electronic address: benazim@ymail.com.
authors.forename: Mohammed Nazim
authors.initials: MN
authors.lastname: Bennaoum
authors.affiliation: Department of Hemobiology, EHU "1er Novembre 1954", Oran, Algeria.
authors.forename: Hassiba
authors.initials: H
authors.lastname: Lazreg
authors.affiliation: Department of Hemobiology, EHU "1er Novembre 1954", Oran, Algeria; Faculty of Medicine of Oran, Algeria.
authors.forename: Affaf
authors.initials: A
authors.lastname: Adda
authors.affiliation: Department of Hemobiology, EHU "1er Novembre 1954", Oran, Algeria; Faculty of Medicine of Oran, Algeria.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hammadi
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D006402:Hematologic Diseases / Q000097:blood* / Q000175:diagnosis; D006405:Hematology / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008962:Models, Theoretical; D015539:Platelet Activation; D010976:Platelet Count; D010979:Platelet Function Tests; D012372:ROC Curve
keywords: ADVIA 2120i; Platelet defects; Screening method