title: Diagnosing lung cancer using etoposide microparticles labeled with99mTc.
abstract: The diagnosis of lung cancer mostly occurs when the cancer is already in an advanced stage. In this situation, there are few options for the treatment and most of them have few chances of success. In this study, we developed and tested etoposide microparticles as a diagnostic agent for imaging lung cancer at early stages of development. We tested etoposide microparticles labeled with technetium 99m in inducted mice. The results demonstrated that over 10% of the total dose used was uptake by the tumor site. Also, the results showed that the microparticles had a good renal clearance and low uptake by liver and spleen. The data suggest that these micro-radiopharmaceuticals may be used for lung cancer imaging exam, especially single-photo emission computed tomography (SPECT).[Formula: see text].
authors.affiliation: a Brazilian Nuclear Energy Commission , Northeast Center of Nuclear Science, Radiopharmacy Center , Pernambuco , Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvi
authors.affiliation: b Federal University of Rio de Janeiro , Institute of Macromolecules Eloisa Mano , Rio de Janeiro , Brazil.
authors.forename: Cristal
authors.initials: C
authors.lastname: Cerqueira-Coutinho
authors.affiliation: c Federal University of Rio de Janeiro , College of Pharmacy , Rio de Janeiro , Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ricci-Junior
authors.affiliation: d Brazilian Nuclear Energy Commission , Nuclear Engineering Institute , Rio de Janeiro , Brazil.
authors.forename: Sofia Nascimento
authors.initials: SN
authors.lastname: Dos Santos
authors.affiliation: d Brazilian Nuclear Energy Commission , Nuclear Engineering Institute , Rio de Janeiro , Brazil.
authors.forename: Suyene Rocha
authors.initials: SR
authors.lastname: Pinto
authors.affiliation: e Instituto de Pesquisas Energéticas e Nucleares , Centro de Radiofarmácia , São Paulo , Brazil.
authors.forename: Emerson Soares
authors.initials: ES
authors.lastname: Bernardes
authors.affiliation: f Department of Biomedical Engineering , Federal University of Pernambuco , Pernambuco , Brazil.
authors.forename: Patricia Lopes
authors.initials: PL
authors.lastname: Barros de Araujo
authors.affiliation: d Brazilian Nuclear Energy Commission , Nuclear Engineering Institute , Rio de Janeiro , Brazil.
authors.forename: Ralph
authors.initials: R
authors.lastname: Santos-Oliveira
mesh_terms: D000072283:A549 Cells; D000818:Animals; D005047:Etoposide / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D007553:Isotope Labeling; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D051379:Mice; D008863:Microspheres; D013667:Technetium / Q000737:chemistry*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005047:Etoposide; D013667:Technetium
keywords: Radiopharmaceuticals; cancer; micro-radiopharmaceuticals; nuclear medicine; oncology