title: Talin gets SHANKed in the fight for integrin activation.
abstract: Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell-extracellular matrix adhesion, by sequestering integrin activators.
authors.affiliation: the Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Atherton
authors.affiliation: the Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, Manchester M13 9PT, UK.
authors.forename: Christoph
authors.initials: C
authors.lastname: Ballestrem
mesh_terms: D002448:Cell Adhesion; D005109:Extracellular Matrix; D006801:Humans; D016023:Integrins / Q000235:genetics; D016608:Talin / Q000235:genetics*
chemical_list: D016023:Integrins; D016608:Talin