title: Vessel Remodeling after Intima-to-Intima Contact Anastomosis.
abstract: BACKGROUND
  Intima-to-intima microanastomotic vascular remodeling was explored, utilizing a polylactide-caprolactone absorbable vein coupler model (PAVCM), which was designed to simulate a non-absorbable counterpart system with the sole exception of being absorbable.
  
  
  METHODS
  Six New Zealand white rabbits were used. After transection of the jugular vein, 2 PAVCMs were placed, 1 at each transected end. The stumps were slipped through the PAVCMs, and the venous wall was everted 90° to achieve intima-to-intima contact. Reanastomosis of the transected jugular vein was performed bilaterally in 3 rabbits. In the other 3 rabbits, the jugular vein (20 mm) harvested from one side was interpositionally grafted to the jugular vein on the opposite side to ease the anastomotic tension. Patency testing, ultrasonography, and histologic assessments were conducted postoperatively at weeks 2, 4, 12, 16, 22, and 26.
  
  
  RESULTS
  All anastomotic sites were patent, without stenosis, occlusion, or dilatation. In the histologic sections, immature endothelial regeneration was observed at week 2, which was completed by week 4. Regeneration of the tunica media was noted at week 12. Between week 22 and week 26, the tunica media fully regenerated and the coupler dissipated entirely.
  
  
  CONCLUSIONS
  Despite the absence of a coupler to act as an anastomotic buttress, the structure and function of all the vessels appeared normal, even histologically. These outcomes are true milestones in the development of an absorbable vein coupler.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Hyeonjung
authors.initials: H
authors.lastname: Yeo
authors.affiliation: Department of Plastic and Reconstructive Surgery, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Hyodong
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Daegu
authors.initials: D
authors.lastname: Son
authors.affiliation: College of Physical Education, Keimyung University, Daegu, Korea.
authors.forename: Changbae
authors.initials: C
authors.lastname: Hong
authors.affiliation: Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kwon
keywords: Anastomosis, surgical; Microsurgery; Vascular surgical procedures