title: Bisphenol S negatively affects the meotic maturation of pig oocytes.
abstract: Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced.
authors.affiliation: Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary Sciences, Prague, Czech Republic. zalmanovat@af.czu.cz.
authors.forename: Tereza
authors.initials: T
authors.lastname: Žalmanová
authors.affiliation: Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary Sciences, Prague, Czech Republic.
authors.forename: Kristýna
authors.initials: K
authors.lastname: Hošková
authors.affiliation: Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary Sciences, Prague, Czech Republic.|Charles University in Prague, Faculty of Medicine in Pilsen, Biomedical Center and Department of Histology and Embryology, Pilsen, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Nevoral
authors.affiliation: Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary Sciences, Prague, Czech Republic.
authors.forename: Kateřina
authors.initials: K
authors.lastname: Adámková
authors.affiliation: Institute of Animal Science, Prague, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Kott
authors.affiliation: Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Chemistry, Prague, Czech Republic.
authors.forename: Miloslav
authors.initials: M
authors.lastname: Šulc
authors.affiliation: Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Chemistry, Prague, Czech Republic.
authors.forename: Zora
authors.initials: Z
authors.lastname: Kotíková
authors.affiliation: Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary Sciences, Prague, Czech Republic.
authors.forename: Šárka
authors.initials: Š
authors.lastname: Prokešová
authors.affiliation: Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Veterinary Sciences, Prague, Czech Republic.
authors.forename: František
authors.initials: F
authors.lastname: Jílek
authors.affiliation: Charles University in Prague, Faculty of Medicine in Pilsen, Biomedical Center and Department of Histology and Embryology, Pilsen, Czech Republic.
authors.forename: Milena
authors.initials: M
authors.lastname: Králíčková
authors.affiliation: Institute of Animal Science, Prague, Czech Republic.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Petr
mesh_terms: D000818:Animals; D001141:Aromatase / Q000235:genetics; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D008540:Meiosis / Q000187:drug effects*; D009865:Oocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D010636:Phenols / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D011960:Receptors, Estrogen / Q000235:genetics; D013450:Sulfones / Q000494:pharmacology*; D013552:Swine; D000098831:Bisphenol S Compounds
chemical_list: D001141:Aromatase; D010636:Phenols; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D013450:Sulfones; C543008:bisphenol S; D000098831:Bisphenol S Compounds