title: A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes.
abstract: An understanding of the role of inherited cancer predisposition syndromes in pediatric tumor diagnoses continues to develop as more information is learned through the application of genomic technology. Identifying patients and their relatives at an increased risk for developing cancer is an important step in the care of this patient population. The purpose of this review is to highlight various tumor types that arise in the pediatric population and the cancer predisposition syndromes associated with those tumors. The review serves as a guide for recognizing genes and conditions to consider when a pediatric cancer referral presents to the genetics clinic.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Texas Children's Hospital, 1102 Bates St, FC 1200, Houston, TX, 77030, USA. sxscollo@txch.org.
authors.forename: Sarah
authors.identifier: http://orcid.org/0000-0003-2017-0245
authors.initials: S
authors.lastname: Scollon
authors.affiliation: Myriad Genetic Laboratories, Dayton, OH, USA.
authors.forename: Amanda Knoth
authors.initials: AK
authors.lastname: Anglin
authors.affiliation: University of Virginia, Charlottesville, VA, USA.
authors.forename: Martha
authors.initials: M
authors.lastname: Thomas
authors.affiliation: Department of Genetics and Metabolism, Children's National Medical Center, Washington, DC, USA.
authors.forename: Joyce T
authors.initials: JT
authors.lastname: Turner
authors.affiliation: Department of Pediatrics, University of Colorado, Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA.
authors.forename: Kami
authors.initials: K
authors.lastname: Wolfe Schneider
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D008297:Male; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics*; D017410:Practice Guidelines as Topic; D012017:Referral and Consultation; D055815:Young Adult
keywords: Cancer; Genetic testing; Genetics; Pediatric cancer predisposition; Tumors