title: Osteoporosis and autophagy: What is the relationship?
abstract: Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.
authors.affiliation: PhD, Postdoctoral Student, Department of Morphology and Genetics, Division of Histology and Structural Biology, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil.
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Florencio-Silva
authors.affiliation: PhD, Postdoctoral Student, Department of Gynecology, Unifesp, São Paulo, SP, Brazil.
authors.forename: Gisela Rodrigues da Silva
authors.initials: GR
authors.lastname: Sasso
authors.affiliation: Full Professor of the Department of Morphology and Genetics, Division of Histology and Structural Biology, Unifesp, São Paulo, SP, Brazil.
authors.forename: Manuel de Jesus
authors.initials: MJ
authors.lastname: Simões
authors.affiliation: PhD, MD, Department of Obstetrics and Gynecology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
authors.forename: Ricardo Santos
authors.initials: RS
authors.lastname: Simões
authors.affiliation: MSc Student, MD, Department of Obstetrics and Gynecology, FMUSP, São Paulo, SP, Brazil.
authors.forename: Maria Cândida Pinheiro
authors.initials: MC
authors.lastname: Baracat
authors.affiliation: PhD, Adjunct Professor (Habilitation: BR. Livre-docente) of the Department of Morphology, Laboratory of Histology and Embryology, Faculty of Dentistry of Araraquara, Universidade Estadual Paulista (Unesp), Araraquara, SP, Brazil.
authors.forename: Estela
authors.initials: E
authors.lastname: Sasso-Cerri
authors.affiliation: PhD, Adjunct Professor (Habilitation: BR. Livre-docente) of the Department of Morphology, Laboratory of Histology and Embryology, Faculty of Dentistry of Araraquara, Universidade Estadual Paulista (Unesp), Araraquara, SP, Brazil.
authors.forename: Paulo Sérgio
authors.initials: PS
authors.lastname: Cerri
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D005260:Female; D006706:Homeostasis; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010011:Osteocytes / Q000473:pathology; D010024:Osteoporosis / Q000209:etiology* / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats