title: Effects of Caspase 9 Gene Polymorphism in Patients with Prostate Cancer.
abstract: Prostate cancer is one of the most common solid tumors and the second leading cause of the death due to malignancy in men. Caspase 9 (CASP9) is a member of the intrinsic pathway and plays a central role in the apoptosis.
  
  
  
  Genotyping of the CASP9 (rs1052576) polymorphism were performed using real-time polymerase chain reaction for blood samples of prostate cancer patients (n=69) and controls (n=76).
  
  
  
  There were no significant differences between the groups in the frequency of CASP9 genotypes (χ2=1.363; p=0.506). Patients with CASP9 (rs1052576) CT genotype were 12.8 fold higher in pathological stage of pT2a compared to any other stages of cancer (OR=0.078, 95% CI= 0.009-0.062; p=0.004). Also TT genotype carriers were 11.3 times lower in pathological stage of pT2a (OR=11.33, 95% CI=2.39-53.748; p=0.000). C allele carriers were 11.36 fold higher in pathological stage of pT2a compared to any other stages of cancer (OR=0.088, 95% CI=0.019-0.418; p=0.002).
  
  
  
  CASP9 (rs1052576) C allele was decreasing the risk for pathological stage of patients with prostate cancer and also CT genotype had positive impact on pathological stage of patients with prostate cancer. CASP9 (rs1052576) TT genotype was seemed to be associated with higher risk of pathological stage. Those results implicated that CASP9 variations could be associated with severity of prostate cancer.
authors.affiliation: Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey.
authors.forename: Seda Gulec
authors.initials: SG
authors.lastname: Yilmaz
authors.affiliation: Department of Urology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Yencilek
authors.affiliation: Department of Urology, Göztepe Education and Research Hospital, Istanbul, Turkey.
authors.forename: Asif
authors.initials: A
authors.lastname: Yildirim
authors.affiliation: Department of Radiology, Haydarpaşa Education and Research Hospital, Istanbul, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Yencilek
authors.affiliation: Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey turgay.isbir@yeditepe.edu.tr tisbir@superonline.com.
authors.forename: Turgay
authors.initials: T
authors.lastname: Isbir
mesh_terms: D000368:Aged; D000483:Alleles; D053453:Caspase 9 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: D053453:Caspase 9
keywords: Prostate cancer; caspase 9; polymorphism; rs1052576