title: Interactions of noradrenaline and cortisol and the induction of indelible memories.
abstract: The glutamate amplifies noradrenergic effects (GANE) model emphasizes the role of focal glutamate-noradrenaline interactions in creating functional hotspots for prioritized processing of salient stimuli. Here, we briefly outline current evidence that synergistic action of noradrenaline and cortisol enables emotional stimuli to gain privileged access to amygdala-hippocampus circuits, eventually resulting in the formation of indelible memories and posttraumatic stress disorder (PTSD).
authors.affiliation: Department of Psychiatry,University of Bonn,53105 Bonn,Germanyrenehurlemann@icloud.comwolfgang.maier@ukb.uni-bonn.dehttp://renehurlemann.squarespace.com/welcome/http://psychiatrie.uni-bonn.de/.
authors.forename: René
authors.initials: R
authors.lastname: Hurlemann
authors.affiliation: Department of Psychiatry,University of Bonn,53105 Bonn,Germanyrenehurlemann@icloud.comwolfgang.maier@ukb.uni-bonn.dehttp://renehurlemann.squarespace.com/welcome/http://psychiatrie.uni-bonn.de/.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.affiliation: Department of Psychiatry,University of Bonn,53105 Bonn,Germanyrenehurlemann@icloud.comwolfgang.maier@ukb.uni-bonn.dehttp://renehurlemann.squarespace.com/welcome/http://psychiatrie.uni-bonn.de/.
authors.forename: Dirk
authors.initials: D
authors.lastname: Scheele
mesh_terms: D000679:Amygdala; D004644:Emotions; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*
chemical_list: D006854:Hydrocortisone; D009638:Norepinephrine