title: Volume-Staged Stereotactic Radiosurgery for Intracranial Arteriovenous Malformations: Outcomes Based on an 18-Year Experience.
abstract: Radiation-based treatment options of large intracranial arteriovenous malformations (AVM) must balance the likelihood of obliteration with the risk of adverse radiation effects (ARE).
  
  
  
  To analyze the efficacy and risks of volume-staged stereotactic radiosurgery (VS-SRS) for AVM.
  
  
  
  Retrospective study of 34 AVM patients having VS-SRS between 1997 and 2012. A median of 2 stages (range, 2-4) was used to treat a median AVM volume of 22.2 cm 3 (range, 7.4-56.7). The median AVM margin dose was 16 Gy (range, 14-18); the median radiosurgery-based AVM score was 2.81 (range, 1.54-6.45). The median follow-up after VS-SRS was 8.2 years (range, 3-13.3).
  
  
  
  Nidus obliteration was noted in 18 patients (53%) after VS-SRS. The rate of obliteration was 14% at 3 years, 54% at 5 years, and 75% at 7 years. Six patients (18%) had 11 bleeds after VS-SRS. Two patients (6%) remained neurologically stable, 2 (6%) patients had significant deficits, and 2 patients (6%) died. The actuarial risk of a first bleed after VS-SRS was 6% at 1 year, 12% at 3 years, and 19% at 7 years. Six patients (18%) underwent repeat SRS; all achieved nidus obliteration for an overall cure rate of 71%. Two patients (6%) had a permanent ARE after VS-SRS or repeat SRS.
  
  
  
  VS-SRS permitted large volume intracranial AVM to be treated with a low rate of ARE. Further study is needed on dose escalation and decreasing the treatment volume per stage to determine if this will increase the rate of obliteration with this technique.
authors.affiliation: Department of Neurological Surgery.|Department of Radiation Oncology.
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Pollock
authors.affiliation: Department of Neurological Surgery.|Department of Otorhinolaryngology.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Link
authors.affiliation: Department of Radiation Oncology.
authors.forename: Scott L
authors.initials: SL
authors.lastname: Stafford
authors.affiliation: Department of Neurological Surgery.|Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lanzino
authors.affiliation: Department of Radiation Oncology.
authors.forename: Yolanda I
authors.initials: YI
authors.lastname: Garces
authors.affiliation: Department of Radiation Oncology.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Foote
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D013238:Stereotaxic Techniques; D016896:Treatment Outcome; D055815:Young Adult
keywords: Arteriovenous malformation; Complication; Radiosurgery