title: Evaluation of Probably Benign Adnexal Masses in Postmenopausal Women.
abstract: BackgroundPreoperatively identification of malignancy potential of a postmenopausal adnexal masses is important.AimTo evaluate the effectiveness of the Risk of Malignancy Index-2 in presumably benign adnexal masses in postmenopausal women.Study DesignRetrospective, observational study.Methods119 women with postmenopausal adnexal masses with a preliminary diagnosis of benign tumors according to the Risk of Malignancy Index-2 were included. Age, duration of menopause, ultrasonographic findings, and serum CA-125 levels were recorded preoperatively. The definitive diagnosis was based on postoperative histopathological examination.ResultsOf 119 adnexal mass, 10 were malignant and 109 were benign. There was no statistically significant difference with regard to age and tumor size between the groups. The two significant ultrasonographic parameter between groups were the presence of solid area in the mass and bilaterality. Moreover, if the cut off point for serum CA-125 was adjusted to 14.75 IU/mL according to ROC curve, a sensitivity value of 80% and a specificity value of 72% could be achieved to discriminate benign and malign cysts.ConclusionIn the differential diagnosis of benign and malignant adnexal masses in postmenopausal women, the presence of a solid component, bilaterallity based on ultrasonography and high CA-125 values may be used as discriminative criteria. There is no direct relation between the size of the adnexal mass and malignancy potential. Therefore, in the malignancy indexes of postmenopausal women, we recommend lower cut-off values of CA-125 to increase the sensitivity of preoperative evaluation tests without having a great impact on negative predictive values.
authors.affiliation: Department of Gynaecology, Dr. Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Burcu Kisa
authors.initials: BK
authors.lastname: Karakaya
authors.affiliation: Department of Gynaecology, Dr. Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Ozgu
authors.affiliation: Department of Gynaecology, Dr. Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Hatice Celik
authors.initials: HC
authors.lastname: Kansu
authors.affiliation: Department of Gynaecology, Dr. Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Evliyaoglu
authors.affiliation: Department of Gynaecology, Dr. Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Esma
authors.initials: E
authors.lastname: Sarikaya
authors.affiliation: Department of Gynaecology, Dr. Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Bugra
authors.initials: B
authors.lastname: Coskun
authors.affiliation: Department of Gynaecology, Dr. Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
mesh_terms: D000291:Adnexal Diseases / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D012189:Retrospective Studies; D018570:Risk Assessment