title: Syntheses and kinetic studies of cyclisation-based self-immolative spacers.
abstract: Kinetic analysis of the disassembly of self-immolative spacers based on cyclisation processes was performed. Five compounds were synthesized belonging to two different series, and their kinetic constants were determined. Electron-donating substituents gave a slight acceleration but the main effect was steric, and the Thorpe-Ingold effect was indeed particularly effective. Comparison with the self-immolative spacers based on elimination processes showed that cyclisations gave comparable or lower rate, but the corresponding spacers are more difficult to modulate.
authors.affiliation: Institut Curie, PSL Research University, CNRS UMR3666, INSERM U1143, 26 rue d'Ulm, F-75005, Paris, France. Frederic.Schmidt@curie.fr.
authors.forename: Steve
authors.initials: S
authors.lastname: Huvelle
authors.forename: Ahmed
authors.initials: A
authors.lastname: Alouane
authors.forename: Thomas
authors.initials: T
authors.lastname: Le Saux
authors.forename: Ludovic
authors.initials: L
authors.lastname: Jullien
authors.forename: Frédéric
authors.initials: F
authors.lastname: Schmidt