title: The Vietnamese pig as a translational animal model to evaluate tissue engineered heart valves: promising early experience.
abstract: Several animal models are currently used for the surgical implantation of either biologic or biopolymeric scaffolds in order to provide in vivo assessment of tissue-engineered heart valves. The Vietnamese pig (VP) is herein proposed as a suitable recipient to test the function of novel bioengineered valve substitutes, in the reconstruction of the right ventricular outflow tract (RVOT). This review aims to provide a complete and exhaustive panel of physiological parameters and methodological information for preclinical studies of tissue-engineered heart valves in the VP animal model.
authors.affiliation: Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Gallo
authors.affiliation: Department of Animal Medicine, Production and Health, University of Padua, Padua - Italy.
authors.forename: Helen
authors.initials: H
authors.lastname: Poser
authors.affiliation: Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Bottio
authors.affiliation: Department of Experimental and Clinical Medicine, University of Udine, Udine - Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Bonetti
authors.affiliation: Department of Animal Medicine, Production and Health, University of Padua, Padua - Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Franci
authors.affiliation: Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Naso
authors.affiliation: Department of Cardiothoracic Surgery, Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne - Australia.
authors.forename: Edward
authors.initials: E
authors.lastname: Buratto
authors.affiliation: Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Zanella
authors.affiliation: CISRA Institute, University of Turin, Turin - Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Perona
authors.affiliation: Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Dal Lin
authors.affiliation: Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bianco
authors.affiliation: Department of Animal Medicine, Production and Health, University of Padua, Padua - Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Spina
authors.affiliation: Department of Animal Medicine, Production and Health, University of Padua, Padua - Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Busetto
authors.affiliation: Department of Experimental and Clinical Medicine, University of Udine, Udine - Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Marchini
authors.affiliation: Department of Experimental and Clinical Medicine, University of Udine, Udine - Italy.
authors.forename: Fulvia
authors.initials: F
authors.lastname: Ortolani
authors.affiliation: Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.|Cardiovascular Regenerative Medicine, Venetian Institute of Molecular Medicine (VIMM), Biomedical Campus Pietro d'Abano, Padua - Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Iop
authors.affiliation: Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.|Cardiovascular Regenerative Medicine, Venetian Institute of Molecular Medicine (VIMM), Biomedical Campus Pietro d'Abano, Padua - Italy.
authors.forename: Gino
authors.initials: G
authors.lastname: Gerosa
mesh_terms: D064591:Allografts; D000818:Animals; D001021:Aortic Valve / Q000601:surgery; D004452:Echocardiography; D048091:Guided Tissue Regeneration; D006350:Heart Valve Prosthesis; D023421:Models, Animal; D011474:Prosthesis Design; D013552:Swine; D023822:Tissue Engineering