title: MYD88 L265P mutation in cutaneous involvement by Waldenström macroglobulinemia.
abstract: Cutaneous manifestations of Waldenström macroglobulinemia (WM) may occur because of several mechanisms, the least common being direct skin infiltration by neoplastic cells. We report a case of patient that after 4-year history of indolent WM developed skin infiltration by lymphoplasmacytoid cells in the form of a small, mildly indurated plaque on the anterior chest. MYD88 L265P mutation was detected both in the previous bone marrow biopsy and in the cutaneous lesion. We review the impact of this new genetic tool in the diagnosis and treatment of lymphoplasmacytic proliferations.
authors.affiliation: Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Alegría-Landa
authors.affiliation: Department of Pathology, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Prieto-Torres
authors.affiliation: Lymphoma Unit, Oncohealth Institute, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: Carlos
authors.identifier: http://orcid.org/0000-0002-1335-0339
authors.initials: C
authors.lastname: Santonja
authors.affiliation: Department of Hematology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: Raul
authors.initials: R
authors.lastname: Córdoba
authors.affiliation: Lymphoma Unit, Oncohealth Institute, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Manso
authors.affiliation: Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: Luis
authors.identifier: http://orcid.org/0000-0002-1347-3507
authors.initials: L
authors.lastname: Requena
authors.affiliation: Lymphoma Unit, Oncohealth Institute, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: Socorro M
authors.initials: SM
authors.lastname: Rodríguez-Pinilla
keywords: MYD88 L265P mutation; Waldenström macroglobulinemia; skin involvement