title: Research Progress on18F-Labeled Agents for Imaging of Myocardial Perfusion with Positron Emission Tomography.
abstract: Coronary artery disease (CAD) is the leading cause of death in the world. Myocardial perfusion imaging (MPI) plays a significant role in non-invasive diagnosis and prognosis of CAD. However, neither single-photon emission computed tomography nor positron emission tomography clinical MPI agents can absolutely satisfy the demands of clinical practice. In the past decades, tremendous developments happened in the field of18F-labeled MPI tracers. This review summarizes the current state of18F-labeled MPI tracers, basic research data of those tracers, and the future direction of MPI tracer research.
authors.affiliation: Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. mtt207@163.com.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Mou
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China. zhangxzh@xmu.edu.cn.
authors.forename: Xianzhong
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000378:metabolism; D005462:Fluorine Radioisotopes / Q000378:metabolism*; D006801:Humans; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals / Q000378:metabolism*
chemical_list: D005462:Fluorine Radioisotopes; D011849:Radioactive Tracers; D019275:Radiopharmaceuticals
keywords: 18F-labeled radiotracers; lipophilic cations; mitochondrial complex-1; myocardial perfusion imaging; positron emission tomography