title: NUSAP1 promotes invasion and metastasis of prostate cancer.
abstract: We have previously identified nucleolar and spindle associated protein 1 (NUSAP1) as a prognostic biomarker in early stage prostate cancer. To better understand the role of NUSAP1 in prostate cancer progression, we tested the effects of increased and decreased NUSAP1 expression in cell lines, in vivo models, and patient samples. NUSAP1 promotes invasion, migration, and metastasis, possibly by modulating family with sequence similarity 101 member B (FAM101B), a transforming growth factor beta 1 (TGFβ1) signaling effector involved in the epithelial to mesenchymal transition. Our findings provide insights into the importance of NUSAP1 in prostate cancer progression and provide a rationale for further study of NUSAP1 function, regulation, and clinical utility.
authors.affiliation: Department of Urology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Gordon
authors.affiliation: Department of Urology, Stanford University School of Medicine, Stanford, CA, 94305, USA.|Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
authors.forename: Xue
authors.initials: X
authors.lastname: Gong
authors.affiliation: Department of Urology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
authors.forename: Durga
authors.initials: D
authors.lastname: Ganesh
authors.affiliation: Department of Urology, Stanford University School of Medicine, Stanford, CA, 94305, USA.|Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Brooks
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D004195:Disease Models, Animal; D018450:Disease Progression; D015870:Gene Expression; D020869:Gene Expression Profiling; D055785:Gene Knockdown Techniques; D064593:Heterografts; D006801:Humans; D008297:Male; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000235:genetics* / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D008869:Microtubule-Associated Proteins; C000709213:NUSAP1 protein, human
keywords: NUSAP1; invasion; metastasis; migration; prostate cancer