title: Circulating tumor cells and miRNAs as prognostic markers in neuroendocrine neoplasms.
abstract: The prognosis of neuroendocrine neoplasms (NENs) is widely variable and has been shown to associate with several tissue- and blood-based biomarkers in different settings. The identification of prognostic factors predicting NEN outcome is of paramount importance to select the best clinical management for these patients. Prognostic markers have been intensively investigated, also taking advantage of the most modern techniques, in the perspective of personalized medicine and appropriate resource utilization. This review summarizes the available data on the possible role of circulating tumor cells and microRNAs as prognostic markers in NENs.
authors.affiliation: Department of Medical SciencesSection of Endocrinology and Internal Medicine, University of Ferrara, Ferrara, Italy ztlmch@unife.it.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Zatelli
authors.affiliation: Endocrine UnitASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
authors.forename: Erika Maria
authors.initials: EM
authors.lastname: Grossrubatscher
authors.affiliation: Department of Advanced Biomedical SciencesPathology Section, University of Naples Federico II, Naples, Italy.
authors.forename: Elia
authors.initials: E
authors.lastname: Guadagno
authors.affiliation: IOS & COLEMAN SrlNaples, Italy.
authors.forename: Concetta
authors.initials: C
authors.lastname: Sciammarella
authors.affiliation: Thyroid and Parathyroid Surgery UnitIstituto Nazionale per lo Studio e la Cura Dei Tumori 'Fondazione G. Pascale' - IRCCS, Naples, Italy.
authors.forename: Antongiulio
authors.initials: A
authors.lastname: Faggiano
authors.affiliation: IOS & COLEMAN SrlNaples, Italy.
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D009360:Neoplastic Cells, Circulating; D018358:Neuroendocrine Tumors / Q000097:blood*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: CTC; circulating biomarkers; miRNA; neuroendocrine tumors; prognosis