title: [α-Lipoic acid as the main pharmacological drug for in- and outpatient treatment of diabetic polyneuropathy].
abstract: α-Lipoic acid, or thioctic acid, (ALA) is the most applicable pharmacological drug for treatment of diabetic polyneuropathy. The article explores the results of experimental studies on the α-lipoic acid effect on mechanisms of peripheral nerves affection in hyperglycemia as well as the data of numerous randomized controlled trials and meta-analyses on studying ALA efficacy in symptomatic diabetic polyneuropathy. It has been shown that amelioration of patients with diabetic polyneuropathy is observed both for ALA infusions and tableted form of the drug. The authors conclude that α-lipoic acid is a drug for treatment of pathogenetic development mechanisms of diabetic polyneuropathy with the best proven efficacy.
authors.affiliation: Sechenov First Moscow State Medical University, Chair of Neurology, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Strokov
authors.affiliation: Sechenov First Moscow State Medical University, Chair of Neurology, Moscow, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Phokina
mesh_terms: D000553:Ambulatory Care; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D008063:Thioctic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D008063:Thioctic Acid