title: Adipose Tissue-Derived Stem Cells for Myocardial Regeneration.
abstract: Over the past decade, stem cell therapy has been extensively studied for clinical application for heart diseases. Among various stem cells, adipose tissue-derived stem cell (ADSC) is still an attractive stem cell resource due to its abundance and easy accessibility.In vitrostudies showed the multipotent differentiation potentials of ADSC, even differentiation into cardiomyocytes. Many pre-clinical animal studies have also demonstrated promising therapeutic results of ADSC. Furthermore, there were several clinical trials showing the positive results in acute myocardial infarction using ADSC. The present article covers the brief introduction, the suggested therapeutic mechanisms, application methods including cell dose and delivery, and human clinical trials of ADSC for myocardial regeneration.
authors.affiliation: Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Joo
authors.affiliation: Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Soon Jun
authors.initials: SJ
authors.lastname: Hong
keywords: Adipose tissue; Myocardium; Regeneration; Stem cell