title: [Flibanserin as pharmacological therapy of inhibited sexual desire in women].
abstract: Flibanserin was approved by the Food and Drug Administration in the USA in August 2015 as the first drug for the treatment of American women with the dysfunction hypoactive sexual desire disorder (HSDD) and is a 5-HT1A agonist and 5-HT2A antagonist. The neurophysiological effects of flibanserin on these receptors are consistent with the clinical effects, i.e. significantly increasing sexual desire and frequency of satisfying sexual experiences. As such, shifting the balance between inhibitory and excitatory neurotransmitters of importance to sexual desire, flibanserin pharmacologically broaches a possible new approach to the treatment of HSDD.
authors.affiliation: annesofie.eldon@gmail.com.
authors.forename: Anne Sofie
authors.initials: AS
authors.lastname: Eldon
authors.forename: Annamaria
authors.initials: A
authors.lastname: Giraldi
mesh_terms: D001562:Benzimidazoles / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007989:Libido / Q000187:drug effects; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use; D020018:Sexual Dysfunctions, Psychological / Q000188:drug therapy*
chemical_list: D001562:Benzimidazoles; D058830:Serotonin 5-HT2 Receptor Antagonists; D017366:Serotonin Receptor Agonists; C098107:flibanserin