title: Diagnosis and management of skin and soft-tissue infections (SSTI). A literature review and consensus statement: an update.
abstract: Skin and soft-tissue infections (SSTIs) are among the most common bacterial infections, posing considerable diagnostic and therapeutic challenges. Fourteen members of the Italian Society of Infectious Diseases, after a careful review of the most recent literature using Medline database and their own clinical experience, updated a previous paper published in 2011 by preparing a draught manuscript of the statements. The manuscript was successively reviewed by all members and ultimately re-formulated the present manuscript during a full day consensus meeting. The microbiological and clinical aspects together with diagnostic features were considered for necrotizing and not necrotizing SSTIs in the light of the most recent guidelines and evidences published in the last five years. The antimicrobial therapy was considered as well - both empirical and targeted to methicillin-resistant Staphylococcus aureus and/or other pathogens, also taking into account the epidemiological and bacterial resistance data and the availability of new antibacterial agents.
authors.affiliation: a Department of Infectious Diseases, AOU San Giovanni di Dio e Ruggi d'Aragona , University of Salerno , Salerno , Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Esposito
authors.affiliation: b Infectious Diseases Division , Santa Maria Misericordia Hospital , Udine , Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Bassetti
authors.affiliation: c Division of Infectious Diseases, Department of Pathology , AOU di Verona, Policlinico 'G.B. Rossi' , Verona , Italy.
authors.forename: Ercole
authors.initials: E
authors.lastname: Concia
authors.affiliation: a Department of Infectious Diseases, AOU San Giovanni di Dio e Ruggi d'Aragona , University of Salerno , Salerno , Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Simone
authors.affiliation: d Department of Medical Science , University of Turin, Infectious Diseases Amedeo di Savoia Hospital , Turin , Italy.
authors.forename: Francesco G
authors.initials: FG
authors.lastname: De Rosa
authors.affiliation: e Infectious Diseases Unit , University of Insubria and University Hospital 'ASST Sette Laghi' , Varese , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Grossi
authors.affiliation: f Department of Health Sciences, Section of Clinical Pharmacology and Oncology , University of Florence , Florence , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Novelli
authors.affiliation: g Infectious Diseases Unit , Nuovo Santa Chiara Hospital , Pisa , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichetti
authors.affiliation: h National Institute for Infectious Diseases Lazzaro Spallanzani-INMU IRCCS , Rome , Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Petrosillo
authors.affiliation: i Division of Infectious and Tropical Diseases , Hospital of Lodi , Lodi , Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Tinelli
authors.affiliation: j Institute of Infectious Diseases , Catholic University of the Sacred Hearth, A. Gemelli Hospital , Rome , Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Tumbarello
authors.affiliation: k Institute of Microbiology , Università Cattolica del Sacro Cuore , Rome , Italy.
authors.forename: Maurizio
authors.identifier: http://orcid.org/0000-0002-9780-7059
authors.initials: M
authors.lastname: Sanguinetti
authors.affiliation: l Department of Medical Surgical Sciences , Alma Mater Studiorum University of Bologna , Bologna , Italy.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Viale
authors.affiliation: m Department of Public Health and Infectious Diseases , 'Sapienza' University of Rome , Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Venditti
authors.affiliation: n Infectious Diseases Division , University of Genoa and IRCCS San Martino-IST , Genoa , Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Viscoli
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D032921:Consensus; D019468:Disease Management; D006801:Humans; D017192:Skin Diseases, Bacterial / Q000175:diagnosis / Q000188:drug therapy*; D018461:Soft Tissue Infections / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents
keywords: Acute bacterial skin and skin-structure infection (ABSSSI); Antibiotics; Skin and soft-tissue infections (SSTIs)