title: Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper.
abstract: Nine new sesquiterpene quinones/hydroquinones (1-7, 10, and 12), three solvent-generated artifacts (8, 9, and 11), and three known compounds, 5-epi-smenospongine (13), smenospongine (14), and smenospongiadine (15), were isolated from the marine sponge Spongia pertusa Esper. The planar structures of the new compounds were elucidated on the basis of spectroscopic analyses. Their absolute configurations were determined by comparison between the calculated and experimental ECD spectra. In the cytotoxicity bioassay, compounds 13-15 exhibited activities against the human cancer cell lines U937, HeLa, and HepG2, with most potent cytotoxicities to U937 cells with IC50values of 2.8, 1.5, and 0.6 μM, respectively. In addition, compound 6 displayed CDK-2 affinity with a Kdvalue of 4.8 μM in a surface plasmon resonance assay.
authors.affiliation: Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.|College of Pharmacy, Jinan University , Guangzhou 510632, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Gu
authors.affiliation: Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Sun
authors.affiliation: Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine , Shanghai 20025, China.
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Xu
authors.affiliation: Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Jiao
authors.affiliation: Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.
authors.forename: Hao-Bing
authors.initials: HB
authors.lastname: Yu
authors.affiliation: Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.
authors.forename: Bing-Nan
authors.initials: BN
authors.lastname: Han
authors.affiliation: Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Institute of Pharmaceutical & Food Engineering, Shanxi University of Traditional Chinese Medicine , Taiyuan 030024, China.
authors.forename: Xi-Chun
authors.initials: XC
authors.lastname: Zhang
authors.affiliation: Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127, China.
authors.forename: Hou-Wen
authors.identifier: 0000-0002-7097-0876
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells / Q000187:drug effects*; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C414693:5-epi-smenospongine; D006873:Hydroquinones; D011809:Quinones; D012717:Sesquiterpenes; C489442:smenospongine