title: Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues.
abstract: The expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to somatostatin analogues (SSA). Our aim was to evaluate the value of the immunohistochemical (IHC) scores of 2 subtypes, SSTR2 and SSTR5, in predicting the short-term efficacy of SSA therapy in patients with active acromegaly. Ninety-three newly diagnosed acromegalic patients were included in our study. These patients were categorized into either a SSA-pretreated group (SA,n= 63) or a direct-surgery group (DS,n= 30), depending on whether or not presurgical SSA treatment was received. IHC analysis, using a 12-grade scoring system, with rabbit monoclonal antibodies against SSTR2 and SSTR5, was performed on all adenoma tissues. The reduction of GH, IGF-1, and tumor size after treatment with SSA for 3 months was measured. Compared with that in the DS group, SSTR2 expression was lower in the SA group. Additionally, in the SA group, SSTR2 expression was positively correlated with the reduction of IGF-1 and tumor volume. However, there was no correlation between the SSTR5 score and the efficacy of SSA. In conclusion, the protein expression of SSTR2, but not of SSTR5, is a valuable indicator in predicting biochemical and tumor size response to short-term SSA treatment in acromegalic patients.
authors.affiliation: Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China; Institute of Endocrinology and Diabetology, Fudan University, Shanghai 200040, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Kunshan Rehabilitation Hospital, Suzhou, Jiangsu 215314, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Xie
authors.affiliation: Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China; Institute of Endocrinology and Diabetology, Fudan University, Shanghai 200040, China.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.affiliation: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China; Shanghai Pituitary Tumor Center, Shanghai 200040, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.affiliation: Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China; Institute of Endocrinology and Diabetology, Fudan University, Shanghai 200040, China.
authors.forename: Yeping
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China; Institute of Endocrinology and Diabetology, Fudan University, Shanghai 200040, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215004, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Hu
authors.affiliation: Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China; Shanghai Pituitary Tumor Center, Shanghai 200040, China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Ye
authors.affiliation: Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China; Institute of Endocrinology and Diabetology, Fudan University, Shanghai 200040, China; Shanghai Pituitary Tumor Center, Shanghai 200040, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China; Shanghai Pituitary Tumor Center, Shanghai 200040, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China; Institute of Endocrinology and Diabetology, Fudan University, Shanghai 200040, China; Shanghai Pituitary Tumor Center, Shanghai 200040, China.
authors.forename: Zhaoyun
authors.identifier: 0000-0001-5366-1353
authors.initials: Z
authors.lastname: Zhang