title: Enantioselective [4 + 1] cycloaddition of ortho-quinone methides and bromomalonates under phase-transfer catalysis.
abstract: An enantioselective [4 + 1] cycloaddition reaction of ortho-quinone methides and bromomalonates using a quinine and BINOL derived phase-transfer catalyst is described. With high yields and enantioselectivities, the method provided a variety of optically active dihydrobenzofurans, which represent a valuable structural motif present in numerous naturally occurring and biologically active molecules.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. hanzy@ustc.edu.cn.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Lian
authors.forename: Alafate
authors.initials: A
authors.lastname: Adili
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Zhong-Lin
authors.initials: ZL
authors.lastname: Tao
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Han
mesh_terms: D002384:Catalysis; D061565:Cycloaddition Reaction; D045563:Indolequinones / Q000138:chemical synthesis* / Q000737:chemistry*; D008314:Malonates / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D045563:Indolequinones; D008314:Malonates; C517405:bromomalonic acid; C068040:quinone methide