title: Functional brain alterations during self-reference processing in adolescents with sexual abuse-related post-traumatic stress disorder: A preliminary report.
abstract: We proposed to explore the functional brain changes during a self-reference processing (SRP) task in adolescents with sexual abuse-related post-traumatic stress disorder (N = 10), compared with healthy adolescents (N = 10). While patients showed no behavioral disturbances in (SRP), they exhibited changes in activity and connectivity in regions involved in emotional regulation (amygdala and dorsal prefrontal cortex) and semantic memory (temporal and ventrolateral prefrontal regions). These preliminary results suggest that these alterations may have an effect on self-esteem which may contribute to a possible retention and impairment of symptoms in adulthood.
authors.affiliation: a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Dégeilh
authors.affiliation: a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.
authors.forename: Armelle
authors.initials: A
authors.lastname: Viard
authors.affiliation: a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.|b CHU de Caen , Service de Psychiatrie de l'Enfant et de l'Adolescent , Caen , France.
authors.forename: Fabian
authors.initials: F
authors.lastname: Guénolé
authors.affiliation: a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.
authors.forename: Malo
authors.initials: M
authors.lastname: Gaubert
authors.affiliation: b CHU de Caen , Service de Psychiatrie de l'Enfant et de l'Adolescent , Caen , France.
authors.forename: Pierre-Jean
authors.initials: PJ
authors.lastname: Egler
authors.affiliation: a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Egret
authors.affiliation: c CHU de Rouen , Fédération hospitalo-universitaire de psychiatrie de l'enfant et de l'adolescent , Rouen , France.
authors.forename: Priscille
authors.initials: P
authors.lastname: Gerardin
authors.affiliation: a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.|b CHU de Caen , Service de Psychiatrie de l'Enfant et de l'Adolescent , Caen , France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Baleyte
authors.affiliation: a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.
authors.forename: Francis
authors.initials: F
authors.lastname: Eustache
authors.affiliation: d CHGR Rennes-I , Service de Psychiatrie de l'Enfant et de l'Adolescent , Rennes , France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Dayana
authors.affiliation: a Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, Neuropsychologie et Imagerie de la Mémoire Humaine , Caen , France.
authors.forename: Bérengère
authors.initials: B
authors.lastname: Guillery-Girard
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D011601:Psychophysics; D012742:Sex Offenses / Q000523:psychology*; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging / Q000473:pathology* / Q000523:psychology*
chemical_list: D010100:Oxygen
keywords: Post-traumatic stress disorder; amygdala; functional connectivity; functional magnetic resonance imaging; prefrontal