title: Efficient syntheses of 3-hydroxyimino-1-isoindolinones and 3-methylene-1-isoindolinones via Cu-promoted C-H activation-nitroalkylation-intramolecular cyclization tandem processes.
abstract: Efficient and selective syntheses of 3-hydroxyimino-1-isoindolinones and 3-methylene-1-isoindolinones were achieved via 8-aminoquinoline assisted Cu-promoted coupling of benzamides with nitroalkanes. The reaction was found to go through C-H activation, nitroalkylation followed by intramolecular cyclization. 3-Hydroxyimino-1-isoindolinones were obtained with nitromethane whereas 3-methylene-1-isoindolinones were produced with higher nitroalkanes.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. ztanze@gmail.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Yu
authors.forename: Hang
authors.initials: H
authors.lastname: Huang
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.forename: Yongqi
authors.initials: Y
authors.lastname: Yu
authors.forename: Ze
authors.initials: Z
authors.lastname: Tan