title: Potential Role of Carvedilol in the Cardiac Immune Response Induced by Experimental Infection withTrypanosoma cruzi.
abstract: Trypanosoma cruzicauses a cardiac infection characterized by an inflammatory imbalance that could become the inciting factor of the illness. To this end, we evaluated the role of carvedilol, a beta-blocker with potential immunomodulatory properties, on the immune response in C57BL/6 mice infected with VL-10 strain ofT. cruziin the acute phase. Animals (n= 40) were grouped: (i) not infected, (ii) infected, (iii) infected + carvedilol, and (iv) not infected + carvedilol. We analyzed parameters related to parasitemia, plasma levels of TNF, IL-10, and CCL2, and cardiac histopathology after the administration of carvedilol for 30 days. We did not observe differences in the maximum peaks of parasitemia in the day of their detection among the groups. The plasma TNF was elevated at 60 days of infection in mice treated or not with carvedilol. However, we observed a decreased CCL2 level and increased IL-10 levels in those infected animals treated with carvedilol, which impacted the reduction of the inflammatory infiltration in cardiac tissue. For this experimental model, carvedilol therapy was not able to alter the levels of circulating parasites but modulates the pattern of CCL2 and IL-10 mediators when the VL10 strain ofT. cruziwas used in C57BL6 mice.
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
authors.forename: Aline Luciano
authors.initials: AL
authors.lastname: Horta
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
authors.forename: Ana Luisa Junqueira
authors.initials: AL
authors.lastname: Leite
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
authors.forename: G
authors.initials: G
authors.lastname: Paula Costa
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
authors.forename: Vivian Paulino
authors.identifier: 0000-0002-2834-8864
authors.initials: VP
authors.lastname: Figueiredo
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas/NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil; Departamento de Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil; Programa de Pós-Graduação em Saúde e Nutrição, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil; Programa de Pós-Graduação em Biomas Tropicais, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
authors.forename: André
authors.identifier: 0000-0002-6685-6229
authors.initials: A
authors.lastname: Talvani
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000150:complications / Q000188:drug therapy* / Q000469:parasitology / Q000503:physiopathology; D018932:Chemokine CCL2 / Q000378:metabolism; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects* / Q000469:parasitology / Q000503:physiopathology; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000472:pathogenicity
chemical_list: C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D016753:Interleukin-10