title: First Clinical Experience Using Stereotactic Breast Biopsy Guided by99mTc-Sestamibi.
abstract: OBJECTIVE
  The purpose of this study is to evaluate a new device using molecular breast imaging (MBI) for99mTc-sestamibi-guided stereotactic lesion localization as a complementary biopsy tool.
  
  
  METHODS
  From December 2012 to May 2016, a total of 38 consecutive women (mean age, 59 years; range, 41-77 years) underwent99mTc-sestamibi-guided biopsy using a new MBI-based device and were retrospectively reviewed. The biopsy modality used five steps: stereotactic localization of the99mTc-sestamibi-avid lesion, calculation of coordinates of the lesion location using dedicated software, placement of the needle, verification of the correct needle position, and tissue sampling with a vacuum-assisted device followed by placement of a radiologic marker at the biopsy site and ex vivo measurement of the biopsy specimens.
  
  
  RESULTS
  The procedure was technically successful in all 38 lesions. In all cases, biopsy samples were radioactive and adequate for histopathologic analysis. Nineteen lesions (50%) were found to be malignant, and the remaining lesions were found to be benign. The mean procedure time was 71 minutes (range, 44-112 minutes). The radiologic marker was successfully deployed in 37 lesions (97%). Two hematomas and three vasovagal reactions were observed.
  
  
  CONCLUSIONS
  Technetium-99m sestamibi-guided biopsy performed using a dedicated MBI-based device is technically feasible and represents a valuable complementary biopsy tool in breast lesion diagnosis.
authors.affiliation: 1 Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.|2 Biomedical Photonic Imaging Group, MIRA Institute, University of Twente, Enschede, The Netherlands.
authors.forename: Angela
authors.initials: A
authors.lastname: Collarino
authors.affiliation: 1 Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.|3 Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.|4 Department of Nuclear Medicine, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Renato A Valdés
authors.initials: RAV
authors.lastname: Olmos
authors.affiliation: 5 Department of Surgery, Alrijne Ziekenhuis, Leiderdorp, The Netherlands.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Neijenhuis
authors.affiliation: 6 Department of Pathology, Alrijne Ziekenhuis, Leiderdorp, The Netherlands.
authors.forename: Wietske C
authors.initials: WC
authors.lastname: den Hartog
authors.affiliation: 1 Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.|3 Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.|7 Department of Nuclear Medicine, Alrijne Ziekenhuis, The Netherlands.
authors.forename: Frederik
authors.initials: F
authors.lastname: Smit
authors.affiliation: 1 Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.|2 Biomedical Photonic Imaging Group, MIRA Institute, University of Twente, Enschede, The Netherlands.|8 Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Lioe-Fee
authors.initials: LF
authors.lastname: de Geus-Oei
authors.affiliation: 1 Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.|7 Department of Nuclear Medicine, Alrijne Ziekenhuis, The Netherlands.
authors.forename: Lenka M Pereira
authors.initials: LMP
authors.lastname: Arias-Bouda
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D061705:Image-Guided Biopsy; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012984:Software; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
keywords: 99mTc-sestamibi; breast cancer; molecular breast imaging; radioguided biopsy