title: Paraneoplastic palmoplantar keratoderma secondary to metastatic uterine adenocarcinoma.
abstract: Palmoplantar keratoderma (PPK) is a dermatosis that presents as hyperkeratosis of the palms and soles. It may be acquired or heritable. Acquired PPK often occurs as a paraneoplastic response as well as a stigma of other dermatoses. We report a rare case of a 72-year-old woman with acquired PPK secondary to metastatic uterine adenocarcinoma. We also review other rare cases of cutaneous paraneoplasia secondary to uterine cancer and describe the salient features of acquired PPK. Acquired PPK most commonly presents as a paraneoplastic response to visceral malignancies that include localized esophageal, pulmonary, urinary/bladder, and gastric carcinomas, as well as myeloma. Management of acquired PPK includes treatment of the underlying cause. Adjunctive vitamin A analogues have been found to be effective.
authors.affiliation: Department of Radiology, Wayne State University, Michigan, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Kallini
authors.affiliation: Division of Dermatology, Department of Medicine, Facey Medical Center, Mission Hills, California, USA.
authors.forename: Khosro
authors.initials: K
authors.lastname: Sadeghani
authors.affiliation: Department of Dermatology, State University of New York Downstate, Brooklyn, USA.
authors.forename: Amor
authors.initials: A
authors.lastname: Khachemoune
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis* / Q000209:etiology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D014594:Uterine Neoplasms / Q000473:pathology*