title: Significant association between lncRNA H19 polymorphisms and cancer susceptibility: a meta-analysis.
abstract: Previous epidemiological research suggests polymorphisms in long non-coding RNA (lncRNA) H19 are associated with an increased risk of cancer, but the results are inconsistent. We therefore conducted a meta-analysis to more accurately determine the association between lncRNA H19 polymorphisms and cancer risk. The PubMed, Embase, and Science Citation Index online databases were searched and 11 relevant studies involving a total of 33,209 participants were identified. Odds ratios (ORs) and corresponding 95% confidence interval (CIs) from these studies were used to detect associations between H19 polymorphisms and cancer risk using five genetic models. The pooled result suggested that the rs2839698 G>A polymorphism was associated with digestive cancer risk in all five models. Moreover, a protective effect against cancer development was observed for the T allele variant of the rs2107425 C>T polymorphism, especially in Caucasian patient populations. No significant associations were found between lncRNA H19 rs217727 G>A polymorphism and cancer risk. In summary, the rs2839698 G>A and rs2107425 C>T polymorphisms in lncRNA H19 may therefore play opposing roles during cancer development, and their effects may vary depending on cancer type and patient ethnicity.
authors.affiliation: Department of Endocrinology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Li
authors.affiliation: Department of Oral and Maxillary Surgery, Gui Zhou Provincial People's Hospital, Guiyang 550000, China.
authors.forename: Xin-Hai
authors.initials: XH
authors.lastname: Yin
authors.affiliation: Department of Endocrinology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Cai
authors.affiliation: Information Resources, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Ming-Ju
authors.initials: MJ
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Zeng
authors.affiliation: Department of Endocrinology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.|Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Niu
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D062085:RNA, Long Noncoding / Q000378:metabolism*
chemical_list: C094335:H19 long non-coding RNA; D062085:RNA, Long Noncoding
keywords: H19; cancer; meta-analysis; polymorphism