title: Genetic variants and increased risk of meningioma: an updated meta-analysis.
abstract: OBJECTIVE
  Various genetic variants have been reported to be linked to an increased risk of meningioma. However, no confirmed conclusion has been obtained. The purpose of the study was to investigate potential meningioma-associated gene polymorphisms, based on published evidence.
  
  
  METHODS
  An updated meta-analysis was performed in September 2016. After electronic database searching and study screening, we selected eligible case-control studies and extracted data for meta-analysis, using Mantel-Haenszel statistics.P-values, pooled odds ratios (ORs), and 95% confidence intervals were calculated.
  
  
  RESULTS
  We finally selected eight genes with ten polymorphisms:MLLT10rs12770228,CASP8rs1045485,XRCC1rs1799782, rs25487,MTHFRrs1801133, rs1801131,MTRRrs1801394,MTRrs1805087,GSTM1 null/present, andGSTT1null/present. Results of meta-analyses showed that there was increased meningioma risk in case groups under all models ofMLLT10rs12770228 (all OR >1,P<0.001), compared with control groups. Similar results were observed under the allele, homozygote, dominant, and recessive models ofMTRRrs1801394 (all OR >1,P<0.05), and the heterozygote and dominant models ofMTHFRrs1801131 in the Caucasian population (all OR >1,P<0.05). However, no significantly increased meningioma risks were observed forCASP8 rs1045485,XRCC1rs25487, rs1799782,MTHFRrs1801133,MTRrs1805087, orGSTM1/GSTT1null mutations.
  
  
  CONCLUSIONS
  Our updated meta-analysis provided statistical evidence for the role ofMLLT10rs12770228,MTRRrs1801394, andMTHFRrs1801131 in increased susceptibility to meningioma.
authors.affiliation: Department of Neurosurgery 3, Cangzhou Central Hospital, Cangzhou.
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Han
authors.affiliation: Department of Ultrasound, Anqiu People's Hospital, Weifang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery 3, Cangzhou Central Hospital, Cangzhou.
authors.forename: Lei-Lei
authors.initials: LL
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery 3, Cangzhou Central Hospital, Cangzhou.
authors.forename: Xi-Rui
authors.initials: XR
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery 3, Cangzhou Central Hospital, Cangzhou.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
keywords: SNP; gene; meningioma; meta-analysis