title: Oral submucous fibrosis: An update on pathophysiology of malignant transformation.
abstract: Oral submucous fibrosis (OSMF) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, USA and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17-year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of OSMF.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Navodaya Dental College and Hospital, Raichur, India.
authors.forename: Gururaj
authors.initials: G
authors.lastname: Arakeri
authors.affiliation: Department of Medical Oncology, HCG Cancer Hospital, Bangalore, India.
authors.forename: Shekar Gowda
authors.initials: SG
authors.lastname: Patil
authors.affiliation: Department of Dentistry, Faculty of Dentistry, King Fahad Medical City, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Abdulsalam S
authors.initials: AS
authors.lastname: Aljabab
authors.affiliation: Department of Oral and Maxillofacial Surgery, Wan-Fang Hospital, Taipei, Taiwan.
authors.forename: Kuan-Chou
authors.initials: KC
authors.lastname: Lin
authors.affiliation: Department of Oral and Maxillofacial Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: M A W
authors.initials: MAW
authors.lastname: Merkx
authors.affiliation: Suzhou Ribo Life Science Co. Ltd., Jiangsu, China.|Xiangya Hospital and School of Stomatology, Central South University, Changsha, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Oral & Maxillofacial Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, UK.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Brennan
mesh_terms: D001114:Areca / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D009062:Mouth Neoplasms / Q000473:pathology*; D009914:Oral Submucous Fibrosis / Q000473:pathology*; D011230:Precancerous Conditions
keywords: malignant transformation; oral submucous fibrosis; review; squamous cell carcinoma