title: Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.
abstract: Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths. The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer agents. In this minireview flubendazole effects towards selected human malignant cells including myeloma, leukemia, neuroblastoma, breast cancer, colorectal cancer and melanoma are discussed along with basic data on its pharmacokinetics, metabolism and toxicity.
authors.affiliation: Charles University, Faculty of Medicine in Hradec Králové, Department of Medical Biology and Genetics, Hradec Králové, Czech Republic.
authors.forename: Kristýna
authors.initials: K
authors.lastname: Čáňová
authors.affiliation: Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology, Hradec Králové, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Rozkydalová
authors.affiliation: Charles University, Faculty of Medicine in Hradec Králové, Department of Medical Biology and Genetics, Hradec Králové, Czech Republic. rudolf@lfhk.cuni.cz.
authors.forename: Emil
authors.initials: E
authors.lastname: Rudolf
mesh_terms: D002470:Cell Survival; D016922:Cellular Senescence / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008463:Mebendazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008870:Microtubules / Q000378:metabolism*; D009101:Multiple Myeloma / Q000188:drug therapy*; D014404:Tubulin / Q000378:metabolism
chemical_list: D014404:Tubulin; D008463:Mebendazole; C018945:flubendazole
keywords: anti-cancer treatment; benzimidazole carbamate; flubendazole; melanoma; microtubules; mitotic catastrophe