title: Estrogen-associated severe hypertriglyceridemia with pancreatitis.
abstract: Estrogen, whether therapeutic or physiologic, can cause hypertriglyceridemia. Hypertriglyceridemia-induced pancreatitis is a rare complication.
  
  
  
  We report 2 women who developed estrogen-associated severe hypertriglyceridemia with pancreatitis. The first patient developed pancreatitis secondary to hypertriglyceridemia associated with in vitro fertilization cycles. Marked reduction in her triglyceride was achieved with dietary restrictions and fibrate. The second patient developed pancreatitis secondary to hypertriglyceridemia during her pregnancies. She was noncompliant with the treatment; therefore, her triglyceride remained high after delivery. In both patients, no hypertriglyceridemia-associated genes mutations were identified, although the second patient had strong polygenic susceptibility to hypertriglyceridemia.
  
  
  
  Estrogen-induced severe hypertriglyceridemia with pancreatitis can be a life-threatening condition. Screening in high-risk patients is crucial to prevent subsequent complications.
authors.affiliation: Department of Cardiology and Research Institute, McGill University Health Center, Montreal, Quebec, Canada. Electronic address: sumayah.aljenedil@mail.mcgill.ca.
authors.forename: Sumayah
authors.initials: S
authors.lastname: Aljenedil
authors.affiliation: Department of Endocrinology and Metabolism, Robarts Research Institute, London, Ontario, Canada.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Hegele
authors.affiliation: Department of Cardiology and Research Institute, McGill University Health Center, Montreal, Quebec, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Genest
authors.affiliation: Department of Cardiology and Research Institute, McGill University Health Center, Montreal, Quebec, Canada; Department of Biochemistry and Molecular Genetics, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
authors.forename: Zuhier
authors.initials: Z
authors.lastname: Awan
mesh_terms: D000328:Adult; D036861:Delivery, Obstetric; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications* / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010195:Pancreatitis / Q000150:complications*; D011247:Pregnancy
chemical_list: D004967:Estrogens
keywords: Estrogen; Hypertriglyceridemia; In vitro fertilization; Pancreatitis; Pregnancy