title: Full Genome Characterization of a New Simian Immune Deficiency Virus Lineage in a Naturally Infected Cercopithecus ascanius whitesidei in the Democratic Republic of Congo Reveals High Genetic Diversity Among Red-Tailed Monkeys in Central and Eastern Africa.
abstract: Our knowledge on simian immune deficiency virus (SIV) diversity and evolution in the different nonhuman primate species is still incomplete. In this study, we report the full genome characterization of a new SIV from a red-tailed monkey (2013DRC-I8), from the Cercopithecus ascanius whitesidei subspecies, in the Democratic Republic of Congo (DRC). The new full-length genome is 9,926 bp long, and the genomic structure is similar to that of other SIVs with the absence of vpx and vpu genes. The new SIVasc-13DRC-I8 strain fell within the Cercopithecus specific SIV lineage. SIVasc-13DRC-I8 and previously reported SIVrtg from the C.a. schmidti subspecies in Uganda did not form a separate species-specific SIV lineage. These observations provide additional evidence for high genetic diversity and the complex evolution of SIVs in the Cercopithecus genus. More studies on a large number of monkeys from a wider geographic area are needed to understand SIV evolution.
authors.affiliation: 1 UMI 233 TransVIHMI/INSERM1175, Institut de Recherche pour le Développement (IRD), University of Montpellier , Montpellier, France .|2 Institut National de Recherche Biomédicales , Kinshasa, Democratic Republic of Congo.|3 Service de Microbiologie, Cliniques Universitaires de Kinshasa , Kinshasa, Democratic Republic of Congo.
authors.forename: Steve
authors.initials: S
authors.lastname: Ahuka-Mundeke
authors.affiliation: 2 Institut National de Recherche Biomédicales , Kinshasa, Democratic Republic of Congo.|3 Service de Microbiologie, Cliniques Universitaires de Kinshasa , Kinshasa, Democratic Republic of Congo.
authors.forename: Placide
authors.initials: P
authors.lastname: Mbala-Kingebeni
authors.affiliation: 2 Institut National de Recherche Biomédicales , Kinshasa, Democratic Republic of Congo.
authors.forename: Simon-Pierre
authors.initials: SP
authors.lastname: Ndimbo-Kumogo
authors.affiliation: 1 UMI 233 TransVIHMI/INSERM1175, Institut de Recherche pour le Développement (IRD), University of Montpellier , Montpellier, France .
authors.forename: Caroline
authors.initials: C
authors.lastname: Foncelle
authors.affiliation: 2 Institut National de Recherche Biomédicales , Kinshasa, Democratic Republic of Congo.|3 Service de Microbiologie, Cliniques Universitaires de Kinshasa , Kinshasa, Democratic Republic of Congo.
authors.forename: Octavie
authors.initials: O
authors.lastname: Lunguya-Metila
authors.affiliation: 2 Institut National de Recherche Biomédicales , Kinshasa, Democratic Republic of Congo.|3 Service de Microbiologie, Cliniques Universitaires de Kinshasa , Kinshasa, Democratic Republic of Congo.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Muyembe-Tamfum
authors.affiliation: 1 UMI 233 TransVIHMI/INSERM1175, Institut de Recherche pour le Développement (IRD), University of Montpellier , Montpellier, France .
authors.forename: Eric
authors.initials: E
authors.lastname: Delaporte
authors.affiliation: 1 UMI 233 TransVIHMI/INSERM1175, Institut de Recherche pour le Développement (IRD), University of Montpellier , Montpellier, France .
authors.forename: Martine
authors.initials: M
authors.lastname: Peeters
authors.affiliation: 1 UMI 233 TransVIHMI/INSERM1175, Institut de Recherche pour le Développement (IRD), University of Montpellier , Montpellier, France .
authors.forename: Ahidjo
authors.initials: A
authors.lastname: Ayouba
mesh_terms: D000818:Animals; D002521:Cercopithecus / Q000821:virology*; D019295:Computational Biology; D015023:Democratic Republic of the Congo; D005838:Genotype; D010802:Phylogeny; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D000073336:Whole Genome Sequencing
keywords: Cercopithecus ascanius; Democratic Republic of Congo; HIV; SIV; red-tailed monkey