title: Mechanisms of type I interferon action and its role in infections and diseases transmission in mammals.
abstract: Interferons (IFNs) are pivotal regulators of immunological processes. This paper describes mainly type I interferons -α and -β and their recently recounted signaling pathways, especially connected with ISGs - interferon stimulated genes, having a crucial role in regulating IFN recruitment. Moreover, the paper shows the data on the role of interferons -α and -β in infections - not only commonly known viral infections, but also bacterial, fungal and parasitic.
authors.affiliation: Department of Immunology, Faculty of Biology, University of Szczecin, Szczecin, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Niedźwiedzka-Rystwej
authors.forename: Weronika
authors.initials: W
authors.lastname: Ratajczak
authors.affiliation: Department of Immunology, Faculty of Biology, University of Szczecin, Szczecin, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Tokarz-Deptuła
authors.affiliation: Department of Microbiology, Faculty of Biology, University of Szczecin, Szczecin, Poland.
authors.forename: Wiesław
authors.initials: W
authors.lastname: Deptuła
mesh_terms: D000818:Animals; D006801:Humans; D007239:Infections / Q000235:genetics* / Q000382:microbiology / Q000635:transmission / Q000821:virology; D016898:Interferon-alpha / Q000235:genetics*; D016899:Interferon-beta / Q000235:genetics*; D008322:Mammals; D015398:Signal Transduction / Q000235:genetics
chemical_list: D016898:Interferon-alpha; D016899:Interferon-beta
keywords: infection; interferon; mammal; signaling pathway