title: Syndrome of inappropriate antidiuretic hormone secretion associated with seronegative neuromyelitis optica spectrum disorder.
abstract: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a potential cause of hyponatremia of the central nervous system (CNS). Although SIADH has been reported to be associated with many other central nervous disorders, its association with neuromyelitis optica (NMO) or NMO spectrum disorders are rare. NMO is a demyelinating disorder characterized by optic neuritis and transverse myelitis. Aquaporin-4 (AQP4), which is the target antigen for a NMO autoantibody, is the predominant CNS water channel. However, some NMO patients show seronegative AQP4 antibody results. The spectrum of NMO has been changed, and new findings about the disease have been reported. Here, we report a case of seronegative NMO spectrum disorder associated with SIADH.
authors.affiliation: Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
authors.forename: Shin Ju
authors.initials: SJ
authors.lastname: Oh
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
authors.forename: Chun Gyoo
authors.initials: CG
authors.lastname: Ihm
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
authors.forename: Tae Won
authors.initials: TW
authors.lastname: Lee
authors.affiliation: Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
authors.forename: Jin Sug
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
authors.forename: Da Rae
authors.initials: DR
authors.lastname: Kim
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Park
authors.affiliation: Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
authors.forename: Su Woong
authors.initials: SW
authors.lastname: Jung
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Neurology, Kyung Hee University Medical Center, Seoul, Korea.
authors.forename: Sung Hyuk
authors.initials: SH
authors.lastname: Heo
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Kyung Hee University Medical Center, Seoul, Korea.
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Jeong
keywords: Aquaporin-4; Neuromyelitis optica; Syndrome of inappropriate antidiuretic hormone secretion