title: Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance.
abstract: Mesenchymal stem cells (MSCs) are ubiquitously present in many tissues. Due to their unique advantages, MSCs have been widely employed in clinical studies. Emerging evidences indicate that MSCs can also migrate to the tumor surrounding stroma and exert complex effects on tumor growth and progression. However, the effect of MSCs on tumor growth is still a matter of debate. Several studies have shown that MSCs could favor tumor growth. On the contrary, other groups have demonstrated that MSCs suppressed tumor progression. Extracellular vesicles have emerged as a new mechanism of cell-to-cell communication in the development of tumor diseases. MSCs-derived extracellular vesicles (MSC-EVs) could mimic the effects of the mesenchymal stem cells from which they originate. Different studies have reported that MSC-EVs may exert various effects on the growth, metastasis, and drug response of different tumor cells by transferring proteins, messenger RNA, and microRNA to recipient cells. In the present review, we summarize the components of MSC-EVs and discuss the roles of MSC-EVs in different malignant diseases, including the related mechanisms that may account for their therapeutic potential. MSC-EVs open up a promising opportunity in the treatment of cancer with increased efficacy.
authors.affiliation: The Key Laboratory of Hematology of Jiangxi Province, The Department of Hematology, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, Jiangxi 330006, China; Basic Medical School, Nanchang University, 465 Bayi Road, Nanchang, Jiangxi 330006, China; Graduate School of Medicine, Nanchang University, 465 Bayi Road, Nanchang, Jiangxi 330006, China.
authors.forename: Xiaoyan
authors.identifier: 0000-0002-3346-3314
authors.initials: X
authors.lastname: Zhang
authors.affiliation: The Department of Neurology, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, Jiangxi 330006, China.
authors.forename: Huaijun
authors.initials: H
authors.lastname: Tu
authors.affiliation: The Key Laboratory of Hematology of Jiangxi Province, The Department of Hematology, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, Jiangxi 330006, China; Graduate School of Medicine, Nanchang University, 465 Bayi Road, Nanchang, Jiangxi 330006, China.
authors.forename: Yazhi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Hematology of Jiangxi Province, The Department of Hematology, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, Jiangxi 330006, China; Graduate School of Medicine, Nanchang University, 465 Bayi Road, Nanchang, Jiangxi 330006, China.
authors.forename: Lijun
authors.identifier: 0000-0002-2653-9034
authors.initials: L
authors.lastname: Fang
authors.affiliation: The Key Laboratory of Hematology of Jiangxi Province, The Department of Hematology, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, Jiangxi 330006, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: The Key Laboratory of Hematology of Jiangxi Province, The Department of Hematology, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, Jiangxi 330006, China.
authors.forename: Jian
authors.identifier: 0000-0003-2396-5342
authors.initials: J
authors.lastname: Li