title: A BODIPY-Based Fluorescent Probe for Detection of Subnanomolar Phosgene with Rapid Response and High Selectivity.
abstract: A new type of phosgene probe with a limit of detection down to 0.12 nM, response time of less than 1.5 s, and high selectivity over other similarly reactive toxic chemicals was developed using ethylenediamine as the recognition moiety and 8-substituted BODIPY unit as the fluorescence signaling component. The probe undergoes sequential phosgene-mediated nucleophilic substitution reaction and intramolecular cyclization reaction with high rate, yielding a product with the intramolecular charge transfer (ICT) process from amine to the BODIPY core significantly inhibited. Owing to the emission feature of 8-substituted BODIPY that is highly sensitive to the substituent's electronic nature, such inhibition on the ICT process strikingly generates strong fluorescence contrast by a factor of more than 23 300, and therefore creates the superhigh sensitivity of the probe for phosgene. Owing to the high reactivity of ethylenediamine of the probe in nucleophilic substitution reactions, the probe displays a very fast response rate to phosgene.
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors.forename: Aidong
authors.initials: A
authors.lastname: Peng
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Jie
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Lv
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
authors.forename: Zhiyuan
authors.identifier: http://orcid.org/0000-0002-1436-6818
authors.initials: Z
authors.lastname: Tian
keywords: ICT; detection limit; ethylenediamine group; intramolecular cyclization; phosgene