title: Potential biomarkers for effective screening of neonatal sepsis infections: An overview.
abstract: Neonatal sepsis, a clinical disorder developed by bacterial blood stream infections (BSI) in neonates, is one of the serious global public health problems that must be addressed. More than one million of the estimated global newborn deaths per year are occurred due to severe infections. The genesis of the infection is divided into early-onset sepsis (EOS) and late-onset sepsis (LOS) of the disease. The clinical complications of neonatal sepsis may be associated with bronchopulmonary dysplasia, ductus arteriosus and necrotizing enterocolitis. The clinical diagnosis and treatment of neonatal sepsis is highly complicated. Over the past few years distinct biomarkers have been identified. Most widely used biomarkers are C-reactive protein, Procalcitonin (PCT) and Serum amyloid A (SAA). Until recently, many potential biomarkers including Cell Surface antigens and Bacterial surface antigens and genetic biomarkers are being investigated. Protein biomarkers, cytokines and chemokines are getting much interest for identification of neonatal sepsis infection.
authors.affiliation: Amity Institute of Nanotechnology, Amity University, Noida, 201303, Uttar Pradesh, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Chauhan
authors.affiliation: Amity Institute of Nanotechnology, Amity University, Noida, 201303, Uttar Pradesh, India.
authors.forename: Sukirti
authors.initials: S
authors.lastname: Tiwari
authors.affiliation: Amity Institute of Nanotechnology, Amity University, Noida, 201303, Uttar Pradesh, India. Electronic address: karshjain@gmail.com.
authors.forename: Utkarsh
authors.initials: U
authors.lastname: Jain
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics; D000954:Antigens, Surface / Q000235:genetics; D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D001424:Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy; D001426:Bacterial Proteins / Q000097:blood / Q000235:genetics; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000235:genetics; D002116:Calcitonin / Q000235:genetics; D018925:Chemokines / Q000097:blood / Q000235:genetics; D016207:Cytokines / Q000097:blood / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D015201:Meta-Analysis as Topic; D000071074:Neonatal Sepsis / Q000175:diagnosis* / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy; D000685:Serum Amyloid A Protein / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001426:Bacterial Proteins; D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D005819:Genetic Markers; C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha; D002116:Calcitonin; D002097:C-Reactive Protein
keywords: Bacterial surface antigens; Biomarkers; Early-onset sepsis; Genetic biomarkers; Late-onset sepsis; Neonatal sepsis