title: Preparation and investigation of controlled-release glipizide novel oral device with three-dimensional printing.
abstract: The purpose of this study was to explore the feasibility of combining fused deposition modeling (FDM) 3D printing technology with hot melt extrusion (HME) to fabricate a novel controlled-release drug delivery device. Glipizide used in the treatment of diabetes was selected as model drug, and was successfully loaded into commercial polyvinyl alcohol (PVA) filaments by HME method. The drug-loaded filaments were printed through a dual-nozzle 3D printer, and finally formed a double-chamber device composed by a tablet embedded within a larger tablet (DuoTablet), each chamber contains different contents of glipizide. The drug-loaded 3D printed device was evaluated for drug release under in vitro dissolution condition, and we found the release profile fit Korsmeyer-Peppas release kinetics. With the double-chamber design, it is feasible to design either controlled drug release or delayed drug release behavior by reasonably arranging the concentration distribution of the drug in the device. The characteristics of the external layer performed main influence on the release profile of the internal compartment such as lag-time or rate of release. The results of this study suggest the potential of 3D printing to fabricate controlled-release drug delivery system containing multiple drug concentration distributions via hot melt extrusion method and specialized design configurations.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Haoyang
authors.initials: H
authors.lastname: Wen
authors.affiliation: Department of Pharmaceutical Information, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Danyang
authors.initials: D
authors.lastname: Jia
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Guan
authors.affiliation: College of Pharmacy, Liaoning University, 66 Chongshan Middle Road, Shenyang 110036, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Pan
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Shihui
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: School of Medical Instrument, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address: xrwlove@163.com.
authors.forename: Rongwu
authors.initials: R
authors.lastname: Xiang
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address: pppwwwsss@163.com.
authors.forename: Weisan
authors.initials: W
authors.lastname: Pan
mesh_terms: D003692:Delayed-Action Preparations; D005913:Glipizide / Q000008:administration & dosage*; D066330:Printing, Three-Dimensional; D013607:Tablets; D013678:Technology, Pharmaceutical
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D005913:Glipizide
keywords: Controlled-release; Double-chamber design; Hot melt extrusion; Multiple drug concentration distributions; PVA; Three dimensional printing