title: Novel boronic acid derivatives of bis(indolyl) methane as anti-MRSA agents.
abstract: Towards the search for a new generation of antibiotics to control methicillin-resistant Staphylococcus aureus (MRSA), the design and synthesis of various bis indolyl methane (BIM) derivatives based on their different electron donor and acceptor properties of the substituents have been made, in which boronic acid derivatives of BIM are found to be active against MRSA. The observed evidence with the lead compound reveals their strong anti-MRSA activity, which paves the way of design and further development of a new generation antibiotics.
authors.affiliation: Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India. Electronic address: mandalsm@gmail.com.
authors.forename: Santi M
authors.initials: SM
authors.lastname: Mandal
authors.affiliation: Department of Chemical Sciences, Tezpur University, Napaam 784028, Assam, India.
authors.forename: Rupa
authors.initials: R
authors.lastname: Pegu
authors.affiliation: Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília-DF, Brazil.
authors.forename: William F
authors.initials: WF
authors.lastname: Porto
authors.affiliation: 4S-Inova Biotech, Pós-graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.
authors.forename: Octavio L
authors.initials: OL
authors.lastname: Franco
authors.affiliation: Department of Chemical Sciences, Tezpur University, Napaam 784028, Assam, India. Electronic address: spratihar29@gmail.com.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Pratihar
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors / Q000378:metabolism; D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D001897:Boronic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008697:Methane / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D062105:Molecular Docking Simulation; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001897:Boronic Acids; D019881:Aminoacyltransferases; C021511:leucyltransferase; D000604:Amino Acyl-tRNA Synthetases; D008697:Methane
keywords: Bacterial cell wall; Bis(indolyl) methane; Leucyl-tRNA synthetase; MRSA; New generation antibiotics