title: GRP78 levels, regional fat distribution and endometrial cáncer.
abstract: BACKGROUND
  The association of obesity with endometrial cancer is supported by the presence of endoplasmic reticulum (ER) stress in the adipocyte. Glucose-regulated protein 78 (GRP78) is a marker for ER stress. This protein is a central regulator of ER stress due to its major anti-apoptotic role. It plays an important role in tumor development, progression and chemoresistance.
  
  
  OBJECTIVE
  To look for an association between android and gynoid obesity, plasma GRP78 levels and endometrial cancer.
  
  
  METHODS
  Forty four patients with endometrial cancer aged 72 ± 6 years and 44 healthy women aged 55 ± 9 years were studied. Android and gynoid fat distribution were determined by dual X-ray absorptiometry and plasma GRP78 levels were measured.
  
  
  RESULTS
  GRP78 plasma levels were significantly higher in patients with endometrial cancer as compared to the control group. Android fat distribution had a positive correlation with plasma GRP78 levels (p<0.01). Gynoid fat had a negative correlation with plasma GRP78 levels (p<0.01).
  
  
  CONCLUSIONS
  GRP78 levels are associated with the distribution of adipose tissue and are higher in patients with endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Răzvan
authors.initials: R
authors.lastname: Ciortea
authors.affiliation: Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Andrei M
authors.initials: AM
authors.lastname: Malutan
authors.affiliation: Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Lenuta M
authors.initials: LM
authors.lastname: Angheluta
authors.affiliation: Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Carmen E
authors.initials: CE
authors.lastname: Bucuri
authors.affiliation: Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Maria P
authors.initials: MP
authors.lastname: Rada
authors.affiliation: Department of Obstetrics and Gynecology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Mihu
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D050218:Body Fat Distribution; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000097:blood* / Q000503:physiopathology; D000091342:Endoplasmic Reticulum Chaperone BiP; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D005260:Female; D006360:Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D014408:Biomarkers, Tumor; D000091342:Endoplasmic Reticulum Chaperone BiP; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins