title: Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging.
abstract: The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), an entirely novel ultrasound-based imaging technique that can map the myocardial fibers orientation and its dynamics with a temporal resolution of 10 ms during a single cardiac cycle, non-invasively and in vivo in entire volumes. 3D-BTI is based on ultrafast volumetric ultrasound acquisitions, which are used to quantify the spatial coherence of backscattered echoes at each point of the volume. The capability of 3D-BTI to map the fibers orientation was evaluated in vitro in 5 myocardial samples. The helicoidal transmural variation of fiber angles was in good agreement with the one obtained by histological analysis. 3D-BTI was then performed to map the fiber orientation dynamics in vivo in the beating heart of an open-chest sheep at a volume rate of 90 volumes/s. Finally, the clinical feasibility of 3D-BTI was shown on a healthy volunteer. These initial results indicate that 3D-BTI could become a fully non-invasive technique to assess myocardial disarray at the bedside of patients.
authors.affiliation: Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France.
authors.forename: Clement
authors.initials: C
authors.lastname: Papadacci
authors.affiliation: Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Finel
authors.affiliation: Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Provost
authors.affiliation: Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Villemain
authors.affiliation: Department of Pathology, Hôpital Européen Georges Pompidou, 21, rue Leblanc, 75015, Paris, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Bruneval
authors.affiliation: Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Gennisson
authors.affiliation: Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France.
authors.forename: Mickael
authors.initials: M
authors.lastname: Tanter
authors.affiliation: Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France.
authors.forename: Mathias
authors.initials: M
authors.lastname: Fink
authors.affiliation: Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, 17 rue Moreau, 75012, Paris, France. mathieu.pernot@inserm.fr.
authors.forename: Mathieu
authors.identifier: http://orcid.org/0000-0001-6713-4642
authors.initials: M
authors.lastname: Pernot
mesh_terms: D000818:Animals; D056324:Diffusion Tensor Imaging / Q000379:methods*; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D012756:Sheep; D013552:Swine