title: The retrosplenial cortex and object recency memory in the rat.
abstract: It has been proposed that the retrosplenial cortex forms part of a 'where/when' information network. The present study focussed on the related issue of whether retrosplenial cortex also contributes to 'what/when' information, by examining object recency memory. In Experiment 1, rats with retrosplenial lesions were found to be impaired at distinguishing the temporal order of objects presented in a continuous series ('Within-Block' condition). The same lesioned rats could, however, distinguish between objects that had been previously presented in one of two discrete blocks ('Between-Block' condition). Experiment 2 used intact rats to map the expression of the immediate-early gene c-fos in retrosplenial cortex following performance of a between-block, recency discrimination. Recency performance correlated positively with levels of c-fos expression in both granular and dysgranular retrosplenial cortex (areas 29 and 30). Expression of c-fos in the granular retrosplenial cortex also correlated with prelimbic cortex and ventral subiculum c-fos activity, the latter also correlating with recency memory performance. The combined findings from both experiments reveal an involvement of the retrosplenial cortex in temporal order memory, which includes both between-block and within-block problems. The current findings also suggest that the rat retrosplenial cortex comprises one of a group of closely interlinked regions that enable recency memory, including the hippocampal formation, medial diencephalon and medial frontal cortex. In view of the well-established importance of the retrosplenial cortex for spatial learning, the findings support the notion that, with its frontal and hippocampal connections, retrosplenial cortex has a key role for both what/when and where/when information.
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
authors.forename: Anna L
authors.identifier: 0000-0003-2070-856X
authors.initials: AL
authors.lastname: Powell
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
authors.forename: Seralynne D
authors.initials: SD
authors.lastname: Vann
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
authors.forename: Cristian M
authors.initials: CM
authors.lastname: Olarte-Sánchez
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
authors.forename: Lisa
authors.initials: L
authors.lastname: Kinnavane
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
authors.forename: Moira
authors.initials: M
authors.lastname: Davies
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
authors.forename: Eman
authors.initials: E
authors.lastname: Amin
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
authors.forename: John P
authors.initials: JP
authors.lastname: Aggleton
authors.affiliation: School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff, CF10 3AT, UK.
authors.forename: Andrew J D
authors.initials: AJD
authors.lastname: Nelson
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D008297:Male; D057567:Memory, Long-Term; D008570:Memory, Short-Term; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism; D051381:Rats; D065852:Spatial Memory
chemical_list: D016760:Proto-Oncogene Proteins c-fos
keywords: c-fos; hippocampus; recognition memory; subiculum; temporal discrimination