title: Amidation of unactivated ester derivatives mediated by trifluoroethanol.
abstract: A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.
authors.affiliation: Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK. craig.jamieson@strath.ac.uk.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: McPherson
authors.forename: Nicola
authors.initials: N
authors.lastname: Caldwell
authors.forename: Craig
authors.initials: C
authors.lastname: Jamieson
authors.forename: Iain
authors.initials: I
authors.lastname: Simpson
authors.forename: Allan J B
authors.initials: AJB
authors.lastname: Watson
mesh_terms: D000577:Amides / Q000737:chemistry*; D004952:Esters / Q000737:chemistry*; D014270:Trifluoroethanol / Q000737:chemistry*
chemical_list: D000577:Amides; D004952:Esters; D014270:Trifluoroethanol