title: The effect of continuous intrathecal baclofen therapy on ambulatory children with cerebral palsy.
abstract: The effect of a continuous intrathecal infusion of baclofen (CITB) was retrospectively studied in 19 ambulatory children with cerebral palsy (aged 12.4±4.9 years at CITB initiation). The mean clinical follow-up was 5.1±2.4 years and the mean follow-up gait analysis was 2.8±1.9 years. Spastic cerebral palsy diagnosis [14 (74%)] was most frequent. Most patients [11 (58%)] were Gross Motor Function Classification System level III. CITB significantly improved muscle tone and knee flexion at initial contact (P<0.05), but it did not lead to improved gait speed or gross motor function.
authors.affiliation: Clinic of Orthopaedics and Paediatric Orthopaedics, Medical University of Lodz, Lodz, Poland.
authors.forename: Blazej
authors.initials: B
authors.lastname: Pruszczynski
authors.affiliation: Department of Orthopedics.
authors.forename: Julieanne
authors.initials: J
authors.lastname: Sees
authors.affiliation: Gait Laboratory, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Hulbert
authors.affiliation: Gait Laboratory, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Church
authors.affiliation: Gait Laboratory, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA.
authors.forename: John
authors.initials: J
authors.lastname: Henley
authors.affiliation: Gait Laboratory, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Niiler
authors.affiliation: Department of Orthopedics.
authors.forename: Freeman
authors.initials: F
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D001418:Baclofen / Q000008:administration & dosage*; D002547:Cerebral Palsy / Q000175:diagnosis* / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D012189:Retrospective Studies; D016896:Treatment Outcome; D016138:Walking / Q000502:physiology*; D055815:Young Adult
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen