title: Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis.
abstract: Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely coordinated by the genetically-primed program that is revealed by the sequential expression of transcription factors. It is important to investigate how spatial allocation of the heart containing cardiomyocytes and other mesoderm-derived cells is determined. In addition, the molecular mechanism underlying cardiomyocyte differentiation still remains elusive. The location of ectoderm-, mesoderm-, and endoderm-derived organs is determined by their initial allocation and subsequent mutual cell-cell interactions or paracrine-based regulation. In the present work, we provide an overview of cardiac development controlled by the germ layers and discuss the points that should be uncovered in future for understanding cardiogenesis.
authors.affiliation: Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Fukui
authors.affiliation: Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Chiba
authors.affiliation: Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Haruko
authors.initials: H
authors.lastname: Takano
authors.affiliation: Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: Management office, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Toyonori
authors.initials: T
authors.lastname: Omori
authors.affiliation: Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.; AMED-CREST, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Mochiuzki
keywords: Cardiac differentiation; Cardiac progenitor cell; Cardiomyocyte; Cilia; Embryo development