title: Crowded optic nerve head evaluation with optical coherence tomography in anterior ischemic optic neuropathy.
abstract: PurposeTo characterize the optic nerve head (ONH) structure in patients with non-arteritic anterior ischemic optic neuropathy (NAION) compared to healthy control subjects using spectral domain optical coherence tomography (SD-OCT) via the enhanced depth imaging method.MethodsIn this prospective, cross-sectional, comparative study, we assessed 66 eyes of 33 patients with unilateral NAION and 31 eyes of 31 healthy normal subjects in an academic institution. The peripapillary nerve fiber layer thickness, disc area, and quantitative parameters of the ONH structures, including the Bruch's membrane opening (BMO) area, anterior laminar depth, and prelaminar thickness and depth were compared between the three groups.ResultsLinear mixed model analysis after adjusting for age, sex, and axial length showed that the BMO area was similar in eyes with NAION (1.89±0.33 mm2), their fellow eyes (1.85±0.35 mm2), and control eyes (1.88±0.37 mm2; all P>0.99). Anterior laminar depth was also similar in the three groups. The mean prelaminar tissue thickness of the NAION eyes was 445±176 μm, which was thinner than the prelaminar tissue of their unaffected fellow eyes (mean, 539±227 μm, P=0.004), but both were thicker than the prelaminar tissue of the normal subjects (mean 243±145 μm, P=0.001 and P<0.001, respectively).ConclusionsThe thick prelaminar thickness is associated with unilateral NAION in the affected and unaffected eyes.
authors.affiliation: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Science, Tehran, Iran.|Koret Vision Center, University of California, San Francisco, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Moghimi
authors.affiliation: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Science, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Afzali
authors.affiliation: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Science, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Akbari
authors.affiliation: Mason Eye Institute, Columbia, MO, USA.
authors.forename: K B
authors.initials: KB
authors.lastname: Ebrahimi
authors.affiliation: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Science, Tehran, Iran.
authors.forename: A
authors.identifier: http://orcid.org/0000-0002-3957-7515
authors.initials: A
authors.lastname: Khodabande
authors.affiliation: Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.
authors.forename: A R
authors.initials: AR
authors.lastname: Yazdani-Abyaneh
authors.affiliation: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Science, Tehran, Iran.
authors.forename: S N H
authors.initials: SNH
authors.lastname: Ghafouri
authors.affiliation: Koret Vision Center, University of California, San Francisco, CA, USA.
authors.forename: P
authors.initials: P
authors.lastname: Coh
authors.affiliation: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Science, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Okhravi
authors.affiliation: Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Science, Tehran, Iran.
authors.forename: M A
authors.initials: MA
authors.lastname: Fard
mesh_terms: D000328:Adult; D000368:Aged; D016570:Bruch Membrane / Q000473:pathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology*; D018917:Optic Neuropathy, Ischemic / Q000473:pathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity; D014794:Visual Fields