title: Which Is the Ideal Marker for Early Atherosclerosis in Obstructive Sleep Apnea (OSA) - Carotid Intima-Media Thickness or Mean Platelet Volume?
abstract: BACKGROUND Obstructive sleep apnea (OSA) is known to be closely associated with cardiovascular disease. Carotid intima-media thickness (IMT) is widely used for assessment of atherosclerosis. Mean platelet volume (MPV) is a new marker associated with atherothrombosis. In this study, we aimed to detect early atherosclerosis by measuring carotid intima-media thickness and to investigate the relationship between MPV and IMT and OSA severity. MATERIAL AND METHODS The study population consisted of 158 patients who underwent polysomnography and did not have any overt cardiac disease or risk factors. Carotid IMT was measured by ultrasonography. Blood samples were taken for MPV determination. Subjects were divided into 4 groups according to OSA severity: control, mild, moderate, and severe OSA. RESULTS CONCLUSIONS OSA patients appear to have increased carotid IMT suggestive of an atherosclerotic process. Carotid IMT could be a more useful indicator than MPV in these patients. Long-term prospective studies are needed to confirm these results.
authors.affiliation: Department of Pulmonary Diseases, Faculty of Medicine, Balikesir University, Balıkesir, Turkey.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Sarioglu
authors.affiliation: Department of Radiology, Faculty of Medicine, Balikesir University, Balıkesir, Turkey.
authors.forename: Gulen
authors.initials: G
authors.lastname: Demirpolat
authors.affiliation: Department of Pulmonary Diseases, Faculty of Medicine, Balikesir University, Balıkesir, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Erel
authors.affiliation: Department of Pulmonary Diseases, Faculty of Medicine, Balikesir University, Balıkesir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kose
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D015415:Biomarkers