title: Evaluation of the effects on choroidal thickness of bimatoprost 0.03% versus a brinzolamide 1.0%/timolol maleate 0.5% fixed combination.
abstract: OBJECTIVE
  To investigate the effects of two different medical treatment options on choroidal thickness (CT) in cases of open-angle glaucoma (OAG).
  
  
  METHODS
  Sixty-seven eyes newly diagnosed with OAG and 52 healthy eyes constituting the control group were included in the study. Glaucomatous eyes were randomly divided into two subgroups; Group I was started on bimatoprost 0.03% and Group II on a brinzolamide 1.0%/timolol maleate 0.5% fixed combination (BTFC). Intraocular pressure (IOP), ocular pulse amplitude (OPA) and subfoveal CT measurements were performed in all eyes in the study before treatment and on weeks 2, 4 and 8 after treatment.
  
  
  RESULTS
  Mean initial IOP values in groups I and II and the control group were 25.5 ± 4.7, 25.1 ± 5.2 and 16.1 ± 2.9 mmHg, mean OPA values were 3.7 ± 1, 3.6 ± 1.4 and 2.4 ± 0.6 mmHg and mean CT values were 269.4 ± 83, 264.5 ± 84.4 and 320.1 ± 56.6 μm, respectively. Eight weeks after treatment, mean IOP values in Groups I and II and the control group were 18.3 ± 2.6, 18.1 ± 3.4 and 15.7 ± 2.9 mmHg, mean OPA values were 2.9 ± 1.2, 2.8 ± 1.5 and 2.3 ± 0.8 mmHg and mean CT values were 290.2 ± 87.3, 271.8 ± 82.5 and 319.3 ± 56.8 μm, respectively. No significant difference was determined in terms of the decrease in IOP and OPA obtained after treatment in Group I and Group II. However, a significant difference was observed between the two groups in terms of choroidal thickening after treatment.
  
  
  CONCLUSIONS
  The use of topical ocular hypotensive medication in eyes with OAG results in an increase in CT. This increase is relatively greater with bimatoprost 0.03% therapy compared to BTFC.
authors.affiliation: a Faculty of Medicine , Department of Ophthalmology, Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Akyol
authors.affiliation: a Faculty of Medicine , Department of Ophthalmology, Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kalkisim
authors.affiliation: a Faculty of Medicine , Department of Ophthalmology, Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Turk
authors.affiliation: a Faculty of Medicine , Department of Ophthalmology, Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kola
authors.affiliation: a Faculty of Medicine , Department of Ophthalmology, Karadeniz Technical University , Trabzon , Turkey.
authors.forename: Halil Ibrahim
authors.initials: HI
authors.lastname: Imamoglu
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D000069580:Bimatoprost / Q000627:therapeutic use*; D002829:Choroid / Q000000981:diagnostic imaging / Q000187:drug effects*; D004338:Drug Combinations; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D016037:Single-Blind Method; D013449:Sulfonamides / Q000627:therapeutic use*; D013843:Thiazines / Q000627:therapeutic use*; D013999:Timolol / Q000627:therapeutic use*; D041623:Tomography, Optical Coherence
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D013449:Sulfonamides; D013843:Thiazines; D013999:Timolol; C111827:brinzolamide; D000069580:Bimatoprost
keywords: Azarga; bimatoprost; choroid; glaucoma; optical coherence; therapy; tomography