title: A Prospective Study of Acute Kidney Injury According to KDIGO Definition and its Mortality Predictors.
abstract: BACKGROUND
  Acute kidney injury is no longer considered to be an innocent bystander merely reflecting co-existent pathologies but an independent risk factor for mortality in the ICU.
  
  
  OBJECTIVE
  To study clinical profile and correlation of patients with acute kidney injury (AKI) according to KDIGO definition with respect to incidence, outcome and different causes of AKI in critical care unit.
  
  
  METHODS
  It is a prospective observational study; and was carried out in the ICU of a tertiary care, teaching, public hospital.
  
  
  METHODS
  We studied 316 patients developing AKI in ICU over a period of 1 year.
  
  
  CONCLUSIONS
  Incidence of AKI in our ICU was 37.71% and mortality rate was 51.9%. Tropical Acute febrile illnesses followed by sepsis were the most common causes of AKI in ICU. Most common cause of AKI among tropical acute febrile illnesses (AFI) was malaria and among sepsis group was lung infection. In our study KDIGO staging could not predict outcome because majority of patients had multisystem failure. Pre-existing co-morbidities, multi-organ system failure were associated with high mortality. APACHE II scoring system under- predicted the mortality in patients with AKI.
authors.affiliation: Associate Professor.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Bhadade
authors.affiliation: Professor, Department of Medicine (MICU).
authors.forename: Rosemarie
authors.initials: R
authors.lastname: De'Souza
authors.affiliation: Associate Professor, Department of Anaesthesiology.
authors.forename: Minal J
authors.initials: MJ
authors.lastname: Harde
authors.affiliation: Professor and Head, Department of Nephrology.
authors.forename: Kalpana S
authors.initials: KS
authors.lastname: Mehta
authors.affiliation: Registrar, Department of Medicine (MICU), Topiwala National Medical College and BYL Nair Ch. Hospital, Mumbai, Maharashtra.
authors.forename: Prabhat
authors.initials: P
authors.lastname: Bhargava
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000401:mortality*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D055815:Young Adult