title: Prediagnostic enterolactone concentrations and mortality among Danish men diagnosed with prostate cancer.
abstract: Evidence on the role of diet in relation to prostate cancer progression is sparse. Foods rich in lignans have shown beneficial effects on prostate cancer progression in both animal studies and small human intervention studies, including beneficial effects on prostate-specific antigen levels and tumour growth. The lignan metabolite, enterolactone, has further shown to slow prostate cancer cell growth in vitro. The aim was to investigate the association between prediagnostic enterolactone concentrations and mortality among men with prostate cancer.Subljects/Methods:Prediagnostic plasma concentrations of enterolactone from 1390 men diagnosed with prostate cancer from the Danish Diet, Cancer and Health cohort were related to all-cause or prostate cancer-specific death, using Cox proportional hazards models with follow-up time (from the date of diagnose until the date of death, emigration or end of follow-up by December 2013) as the underlying time axis.
  
  
  
  The hazard ratios for enterolactone concentrations assessed linearly by 20 nmol/l increments was 0.95 (0.90, 1.02) for all-cause mortality and 0.98 (0.92, 1.05) for prostate cancer-specific mortality. Categorisation of enterolactone concentrations into quartiles did not reveal a different pattern. No effect modifications by smoking, body mass index or sport were observed, and the associations did not differ by prostate cancer aggressiveness.
  
  
  
  We found no association between enterolactone concentrations and mortality among men diagnosed with prostate cancer.
authors.affiliation: Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: A K
authors.initials: AK
authors.lastname: Eriksen
authors.affiliation: Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Kyrø
authors.affiliation: Department of Animal Science, Aarhus University, Tjele, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: Nørskov
authors.affiliation: Department of Animal Science, Aarhus University, Tjele, Denmark.
authors.forename: A K
authors.initials: AK
authors.lastname: Bolvig
authors.affiliation: Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Christensen
authors.affiliation: Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Tjønneland
authors.affiliation: Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus C, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Overvad
authors.affiliation: Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.|Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Landberg
authors.affiliation: Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Olsen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000097:blood; D000328:Adult; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D004032:Diet; D055088:Early Detection of Cancer; D006801:Humans; D017705:Lignans / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000097:blood / Q000401:mortality*; D012042:Registries; D012307:Risk Factors; D016019:Survival Analysis; D044465:White People
chemical_list: D017705:Lignans; D015107:4-Butyrolactone; C029497:2,3-bis(3'-hydroxybenzyl)butyrolactone