title: Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy.
abstract: A new platform constituted by engineered responsive nanoparticles transported by human mesenchymal stem cells is here presented as a proof of concept. Ultrasound-responsive mesoporous silica nanoparticles are coated with polyethylenimine to favor their effective uptake by decidua-derived mesenchymal stem cells. The responsive-release ability of the designed nanoparticles is confirmed, both in vial and in vivo. In addition, this capability is maintained inside the cells used as carriers. The migration capacity of the nanoparticle-cell platform towards mammary tumors is assessed in vitro. The efficacy of this platform for anticancer therapy is shown against mammary tumor cells by inducing the release of doxorubicin only when the cell vehicles are exposed to ultrasound.
authors.affiliation: Dpto. Química Inorgánica y Bioinorgánica, Facultad de Farmacia, UCM, Instituto de Investigación Sanitaria Hospital, 12 de Octubre i+12, 28040-Madrid, Spain. vallet@ucm.es.
authors.forename: Juan L
authors.initials: JL
authors.lastname: Paris
authors.forename: Paz
authors.initials: P
authors.lastname: de la Torre
authors.forename: M
authors.initials: M
authors.lastname: Victoria Cabañas
authors.forename: Miguel
authors.initials: M
authors.lastname: Manzano
authors.forename: Montserrat
authors.initials: M
authors.lastname: Grau
authors.forename: Ana I
authors.initials: AI
authors.lastname: Flores
authors.forename: María
authors.initials: M
authors.lastname: Vallet-Regí
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003656:Decidua / Q000166:cytology*; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers; D005260:Female; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D059630:Mesenchymal Stem Cells / Q000187:drug effects*; D051379:Mice; D053758:Nanoparticles; D016062:Porosity; D017207:Rats, Sprague-Dawley; D012822:Silicon Dioxide; D000069453:Ultrasonic Waves
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide; D004317:Doxorubicin