title: Stereoselective Photoredox-Catalyzed Chlorotrifluoromethylation of Alkynes: Synthesis of Tetrasubstituted Alkenes.
abstract: A new photoredox-catalyzed chlorotrifluoromethylation reaction of internal arylalkynes under mild conditions using visible light has been developed. The reactions proceed with high levels of regio- and stereoselectivity and utilize commercially available CF3SO2Cl as both the CF3and Cl source. In the mechanistic pathway for this process, generation of the CF3radical and chloride ion occurs by Ir(ppy)3-photocatalyzed reductive decomposition of CF3SO2Cl. The synthetically important trifluoromethyl-substituted vinyl chlorides produced in this process can be readily transformed to 1,1-bis-arylalkenes by using Suzuki coupling.
authors.affiliation: Division of Bio & Drug Discovery, Korea Research Institute of Chemical Technology , P.O. Box 107, Yuseong, Daejeon 34114, Republic of Korea.|Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology , 217 Gajeongro, Yuseong, Daejeon 305-355, Republic of Korea.
authors.forename: Hong Sik
authors.initials: HS
authors.lastname: Han
authors.affiliation: Division of Bio & Drug Discovery, Korea Research Institute of Chemical Technology , P.O. Box 107, Yuseong, Daejeon 34114, Republic of Korea.|Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology , 217 Gajeongro, Yuseong, Daejeon 305-355, Republic of Korea.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Division of Bio & Drug Discovery, Korea Research Institute of Chemical Technology , P.O. Box 107, Yuseong, Daejeon 34114, Republic of Korea.|Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology , 217 Gajeongro, Yuseong, Daejeon 305-355, Republic of Korea.
authors.forename: Young-Sik
authors.initials: YS
authors.lastname: Jung
authors.affiliation: Division of Bio & Drug Discovery, Korea Research Institute of Chemical Technology , P.O. Box 107, Yuseong, Daejeon 34114, Republic of Korea.|Department of Medicinal and Pharmaceutical Chemistry, University of Science and Technology , 217 Gajeongro, Yuseong, Daejeon 305-355, Republic of Korea.
authors.forename: Soo Bong
authors.identifier: 0000-0002-7831-1832
authors.initials: SB
authors.lastname: Han