title: Dissociation of reward and effort sensitivity in methcathinone-induced Parkinsonism.
abstract: Methcathinone-induced Parkinsonism is a recently described extrapyramidal syndrome characterized by globus pallidus and substantia nigra lesions, which provides a unique model of basal ganglia dysfunction. We assessed motivated behaviour in this condition using a novel cost-benefit decision-making task, in which participants decided whether it was worth investing effort for reward. Patients showed a dissociation between reward and effort sensitivity, such that pallidonigral complex dysfunction caused them to become less sensitive to rewards, while normal sensitivity to effort costs was maintained.
authors.affiliation: Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, Victoria, Australia.|Department of Experimental Psychology, University of Oxford, UK.|Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
authors.forename: Trevor T-J
authors.identifier: 0000-0001-7764-3811
authors.initials: TT
authors.lastname: Chong
authors.affiliation: Department of Experimental Psychology, University of Oxford, UK.
authors.forename: Valerie
authors.initials: V
authors.lastname: Bonnelle
authors.affiliation: Department of Experimental Psychology, University of Oxford, UK.
authors.forename: Kai-Riin
authors.initials: KR
authors.lastname: Veromann
authors.affiliation: Department of Neurology and Neurosurgery, University of Tartu, Estonia.
authors.forename: Julius
authors.initials: J
authors.lastname: Juurmaa
authors.affiliation: Department of Neurology and Neurosurgery, University of Tartu, Estonia.
authors.forename: Pille
authors.initials: P
authors.lastname: Taba
authors.affiliation: Department of Experimental Psychology, University of Oxford, UK.
authors.forename: Olivia
authors.initials: O
authors.lastname: Plant
authors.affiliation: Department of Experimental Psychology, University of Oxford, UK.|Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
authors.forename: Masud
authors.initials: M
authors.lastname: Husain
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects; D016022:Case-Control Studies; D003657:Decision Making / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D020149:Manganese Poisoning / Q000150:complications*; D009042:Motivation / Q000187:drug effects / Q000502:physiology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000523:psychology*; D011427:Propiophenones / Q000009:adverse effects*; D012201:Reward
chemical_list: D011427:Propiophenones; C047806:monomethylpropion
keywords: Parkinsonism; effort; methcathinone; motivation; reward