title: Process Principles for Large-Scale Nanomanufacturing.
abstract: Nanomanufacturing-the fabrication of macroscopic products from well-defined nanoscale building blocks-in a truly scalable and versatile manner is still far from our current reality. Here, we describe the barriers to large-scale nanomanufacturing and identify routes to overcome them. We argue for nanomanufacturing systems consisting of an iterative sequence of synthesis/assembly and separation/sorting unit operations, analogous to those used in chemicals manufacturing. In addition to performance and economic considerations, phenomena unique to the nanoscale must guide the design of each unit operation and the overall process flow. We identify and discuss four key nanomanufacturing process design needs: (a) appropriately selected process break points, (b) synthesis techniques appropriate for large-scale manufacturing,
authors.affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0100; email: mfiller@gatech.edu.
authors.forename: Sven H
authors.initials: SH
authors.lastname: Behrens
authors.affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0100; email: mfiller@gatech.edu.
authors.forename: Victor
authors.initials: V
authors.lastname: Breedveld
authors.affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0100; email: mfiller@gatech.edu.
authors.forename: Maritza
authors.initials: M
authors.lastname: Mujica
authors.affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0100; email: mfiller@gatech.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Filler
mesh_terms: D004867:Equipment Design; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000191:economics / Q000295:instrumentation / Q000379:methods*; D019064:Product Packaging / Q000191:economics / Q000295:instrumentation / Q000379:methods
keywords: nanomanufacturing; nanotechnology; process design; scale-up