title: A Long Journey Ahead: Long Non-coding RNAs in Bacterial Infections.
abstract: Bacterial pathogens have coevolved with their hosts and acquired strategies to circumvent defense mechanisms of host cells. It was shown that bacteria interfere with the expression of mammalian microRNAs to modify immune signaling, autophagy, or the apoptotic machinery. Recently, a new class of regulatory RNAs, long non-coding RNAs (lncRNAs), was reported to have a pivotal role in the regulation of eukaryotic gene expression. A growing body of literature reports on specific involvement of lncRNAs in the host cell response toward bacterial infections. This mini review summarizes recent data that focuses on lncRNA function in host cells during bacterial infection and provides a perspective where future research in this regard may be going.
authors.affiliation: Department of Veterinary Medicine, Institute of Veterinary Biochemistry, Freie Universität Berlin Berlin, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Zur Bruegge
authors.affiliation: Department of Veterinary Medicine, Institute of Veterinary Biochemistry, Freie Universität Berlin Berlin, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Einspanier
authors.affiliation: Department of Veterinary Medicine, Institute of Veterinary Biochemistry, Freie Universität Berlin Berlin, Germany.
authors.forename: Soroush
authors.initials: S
authors.lastname: Sharbati
mesh_terms: D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007109:Immunity; D035683:MicroRNAs / Q000235:genetics; D062085:RNA, Long Noncoding / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: bacterial infection; epigenetic regulation of gene expression; host-pathogen interaction; immunity; long non-coding RNAs (lncRNAs)