title: MicroRNA-150 regulates glycolysis by targeting von Hippel-Lindau in glioma cells.
abstract: Warburg effect, characterized by enhanced glycolysis and lactate production, even under aerobic conditions, is one of the hallmarks of cancer cells. However, the mechanism underlying this phenomenon remains poorly understood. Previous studies have shown that microRNA-150 (miR-150) is significantly up-regulated in various malignancies and represents a putative onco-miRNA in human cancers. In the present study, we aim to investigate the functional significance and molecular target of miR-150 in glioma. As a result, von Hippel-Lindau (VHL), which is a specific E3 ligase for hypoxia inducible factor 1 (HIF1α), was identified as a novel target of miR-150. Consistently, cells overexpressing miR-150 exhibited a metabolic shift, including enhanced glucose uptake and lactate production, which led to a rapid growth of glioma cells. Therefore, our results suggest that miR-150 modulates the Warburg effect in glioma via VHL/HIF1α and might provide a novel option for future treatments for glioma.
authors.affiliation: Department of Trauma Emergency, Huaihe Hospital of Henan University Kaifeng 475000, Henan, P. R. China.
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Huaihe Hospital of Henan University Kaifeng 475000, Henan, P. R. China.
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Huaihe Hospital of Henan University Kaifeng 475000, Henan, P. R. China.
authors.forename: Shi-Lei
authors.initials: SL
authors.lastname: Tang
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University Jinsui Road, Xinxiang 453003, P. R. China.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Li
authors.affiliation: Department of Biochemistry and Molecular Biology, Xinxiang Medical University Jinsui Road, Xinxiang 453003, P. R. China.
authors.forename: Xiao-Yin
authors.initials: XY
authors.lastname: Wang
keywords: HIF1α; MicroRNA-150; VHL; glioma; warburg effect