title: One-Step Formulation of Targeted Aggregation-Induced Emission Dots for Image-Guided Photodynamic Therapy of Cholangiocarcinoma.
abstract: Photodynamic therapy (PDT) is a palliative technique that can improve median survival with minimal invasion for cholangiocarcinoma (CC) patients. An ideal photosensitizer (PS) is critical to guarantee the efficacy of PDT. However, conventional PSs have some obvious drawbacks, such as lack of specificity and easy aggregation in aqueous media that limit their further application in the clinic. We herein fully take advantage of a red emissive aggregation-induced emission (AIE) PS to fabricate integrin ανβ3targeted organic AIE dots for image-guided PDT via a simple and straightforward one-step strategy. The obtained AIE dots exhibit high specificity to CC as well as excellent antitumor effect both in vitro and in vivo. Different from conventional PSs and previously reported PS-loaded nanostructures, the AIE dots do not suffer from aggregation-caused fluorescence quenching and reduction in reactive oxygen species production when the AIE PS molecules are in an aggregated state. The significant antitumor effect, as well as good biocompatibility and negligible toxicity, makes the AIE dots promising for future translational research in CC diagnosis and therapy.
authors.affiliation: Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China.|State Key Laboratory of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore , Singapore , 117585.
authors.forename: Youyong
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China.
authors.forename: Yuzhe
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China.
authors.forename: Zifang
authors.initials: Z
authors.lastname: Song
authors.affiliation: State Key Laboratory of Luminescent Materials and Devices, South China University of Technology , Guangzhou 510640, China.|Department of Chemistry and Division of Biomedical Engineering, Hong Kong University of Science and Technology , Hong Kong 999077, China.
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore , Singapore , 117585.
authors.forename: Bin
authors.identifier: 0000-0002-0956-2777
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China.
authors.forename: Qi Chang
authors.identifier: 0000-0003-0917-8545
authors.initials: QC
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy; D061848:Optical Imaging; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D066329:Protein Aggregates / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D039302:Integrin alphaVbeta3; D017319:Photosensitizing Agents; D066329:Protein Aggregates
keywords: aggregation-induced emission; cholangiocarcinoma; photodynamic therapy; targeted fluorescence imaging; targeted therapy