title: Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity.
abstract: The aim of this study was to investigate the effects of netrin-1 (NT-1) on amyloid-beta (Aβ)-induced impairments in learning-memory and synaptic plasticity. The NT-1 or its vehicle was administered four times into the Aβ+NT or Aβ+V groups, respectively. The Aβ+SNT group received a single dose of NT-1. The Aβ+HNT group received heat-inactivated NT-1. For the learning-memory and synaptic plasticity assessment, field potentials recording and behavioral experiment were used. Bilateral injection of Aβ1-42inhibits induction of long-term potentiation (LTP) and decreased memory performance in all the behavioral tasks. However, only by repeated injection of NT-1, significant recovery of LTP and memory was seen. Although, the delivery of HFS to Aβ+NT group recovered EPSP slope of the maintenance phase when compared with Aβ+V, but it failed to recover the induction phase. It can be assumed that NT-1 may have regulatory effects on the synthesis of key proteins and/or structural changes that are responsible for LTP induction, since the protein synthesis and/or structural changes are required for the maintenance phase of LTP.
authors.affiliation: Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: shabanimoh@yahoo.com.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shabani
authors.affiliation: Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran; Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: haghani55@yahoo.com.
authors.forename: Masoud
authors.initials: M
authors.lastname: Haghani
authors.affiliation: Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: parisaesmaeil48@yahoo.com.
authors.forename: Parisa Esmaeili
authors.initials: PE
authors.lastname: Tazangi
authors.affiliation: Department of Physiology, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mbayat53@yahoo.com.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Bayat
authors.affiliation: Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mmoosavi@sums.ac.ir.
authors.forename: Seyed Mostafa
authors.initials: SM
authors.lastname: Shid Moosavi
authors.affiliation: Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: hodaranjbar@yahoo.com.
authors.forename: Hoda
authors.initials: H
authors.lastname: Ranjbar
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D007859:Learning Disabilities / Q000139:chemically induced; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced; D000075388:Netrin-1 / Q000378:metabolism* / Q000627:therapeutic use*; D000075385:Netrins / Q000378:metabolism / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects; D009479:Neuropeptides / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016229:Amyloid beta-Peptides; D000075385:Netrins; D009479:Neuropeptides; D010446:Peptide Fragments; D000075388:Netrin-1
keywords: Alzheimer’s disease; Beta amyloid; Long-term potentiation; Netrin-1