title: B-lymphocytic infiltration of the prostate to a patient with chronic lymphocytic leukemia. A case report.
abstract: Involvement of the prostate gland, as an early extra-nodal manifestation of a hematologic disease, or as a secondary infiltration is rare. Even rarer is the acute urinary retention due to infiltration by lymphocytes and simultaneously enlarged prostate. We present a case of a 61 years old male patient with a history of chronic lymphocytic leukemia, who was under oncological follow-up with no active treatment and had typical lower urinary tract symptoms due to benign prostatic hyperplasia and was receiving 5-alpha reductase inhibitor. After an acute urinary retention episode which was managed with a suprapubic catheter due to urethral catheter insertion failure, the patient was submitted to a transurethral prostatectomy. Histological examination revealed lymphocytic infiltration of the prostatic parenchyma by mostly small B cells. B-lymphocytic infiltration of the prostate gland, causes symptoms similar to benign prostatic hyperplasia. Acute urinary retention due to B-lymphocytic infiltration of the prostate is rare and the diagnosis is always histological and an oncological re-evaluation is necessary. The prognosis of these patients is related to the generalized disease rather than to the prostatic involvement.
authors.affiliation: 1st University Urology Clinic, Laiko Hospital, Athens. ekati2@otenet.gr.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Anastasiou
authors.forename: Spyridon
authors.initials: S
authors.lastname: Skoufias
authors.forename: Ioannis
authors.initials: I
authors.lastname: Katafigiotis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Skarmoutsos
authors.forename: Constantinos A
authors.initials: CA
authors.lastname: Constantinides
mesh_terms: D058891:5-alpha Reductase Inhibitors / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000378:metabolism*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D059411:Lower Urinary Tract Symptoms / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology* / Q000601:surgery; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy; D020728:Transurethral Resection of Prostate / Q000379:methods; D016055:Urinary Retention / Q000209:etiology*
chemical_list: D058891:5-alpha Reductase Inhibitors