title: Nanotechnology application to local anaesthesia (LA).
abstract: Several advancements have been made on the exact release of local anaesthetics formulation and its efficiency at inducing motor and sensory block for an extended time has been harnessed in clinical practice. The use of sustained release formulations delivers analgesia for a lengthier period of time with one administration, thereby reducing complications that usually arise with administration of conventional analgesia. In addition, controlled release of an anaesthetic drug is said to prevent overdosing, reduced side effects, especially cardiotoxicity, neurotoxicity and tissue lesions. The use of nanotechnology knowledge via liposomal formulation has recorded high successful results in pain control and quick patient recovery.
authors.affiliation: a Department of Anesthesiology , Lorestan University of Medical Sciences , Khorramabad , Iran.
authors.forename: Mahmoud Reza
authors.initials: MR
authors.lastname: Moradkhani
authors.affiliation: a Department of Anesthesiology , Lorestan University of Medical Sciences , Khorramabad , Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Karimi
authors.affiliation: b Department of Medical Biotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Negahdari
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D036103:Nanotechnology / Q000379:methods*
chemical_list: D000779:Anesthetics, Local; D004337:Drug Carriers
keywords: Anaesthesia; liposome; nanotechnology