title: Clinical Study to Determine the Stain Removal Effectiveness of a New Dentifrice Formulation.
abstract: OBJECTIVE
  This randomized, prospective clinical trial was conducted to determine the safety and effectiveness of a new whitening dentifrice formulation in comparison to that of both a negative and a positive control dentifrice.
  
  
  METHODS
  Seventy-nine qualifying subjects were randomly assigned to either the new whitening dentifrice (Arm & Hammer® Truly Radiant™ Clean & Fresh Toothpaste), a positive control whitening dentifrice (Crest® 3-D White® Radiant Mint Toothpaste), or a negative control regular dentifrice (Colgate® Cavity Protection Toothpaste). The subjects brushed with their assigned dentifrice for two minutes, twice daily, for five days. Extrinsic tooth stain was assessed using a Modified Lobene Stain Index (MLSI) at baseline and after five days of product use.
  
  
  RESULTS
  All entering subjects completed the study. There were no significant differences (p > 0.05) in stain among the three groups at baseline. The Arm & Hammer Truly Radiant and positive control groups had statistically significant (p < 0.001) mean composite MLSI reduction scores of 13.2% and 7.8%, respectively, from baseline to day five. The negative control dentifrice group was virtually unchanged during this period. Intergroup comparisons showed the Truly Radiant group to have significantly greater stain removal (p < 0.0001) scores than the negative control. The Truly Radiant group also had greater stain removal than the positive control, though the differences were not statistically significant.
  
  
  CONCLUSIONS
  This study demonstrates that five-days' use of Arm & Hammer Truly Radiant Clean & Fresh dentifrice was significantly more effective in stain removal than a regular (non-whitening) dentifrice and comparable in effectiveness to a whitening dentifrice positive control.
authors.affiliation: Church & Dwight Co., Inc., Princeton, NJ, USA.
authors.forename: A
authors.initials: A
authors.lastname: Buelo
authors.affiliation: Church & Dwight Co., Inc., Princeton, NJ, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ghassemi
authors.affiliation: Church & Dwight Co., Inc., Princeton, NJ, USA.
authors.forename: L
authors.initials: L
authors.lastname: Vorwerk
authors.affiliation: Church & Dwight Co., Inc., Princeton, NJ, USA.
authors.forename: W
authors.initials: W
authors.lastname: Hooper
authors.affiliation: Oral Health Clinical Services, LLC, Piscataway, NJ, USA.
authors.forename: S
authors.initials: S
authors.lastname: Nathoo
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004396:Coloring Agents; D003802:Dentifrices / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D014073:Tooth Bleaching; D014075:Tooth Discoloration / Q000628:therapy*; D014100:Toothpastes; D016896:Treatment Outcome
chemical_list: D004396:Coloring Agents; D003802:Dentifrices; D014100:Toothpastes; D012822:Silicon Dioxide; D012969:Sodium Fluoride
keywords: Baking soda; Extrinsic stain; Modified Lobene Stain Index; Whitening dentifrice