title: A 15-year epileptogenic period after perinatal brain injury.
abstract: Seizures are a frequent acute neurological event in the neonatal period. Up to 12 to 18% of all seizures in newborns are due to perinatal stroke and up to 39% of affected children can then develop epilepsy in childhood. We report the case of a young patient who presented stroke-related seizures in the neonatal period and then developed focal symptomatic epilepsy at 15 years of age, and in whom the epileptic focus was found to co-localize with the site of his ischemic brain lesion. Such a prolonged silent period before onset of remote symptomatic epilepsy has not previously been reported. This case suggests that newborns with seizures due to a neonatal stroke are at higher risk of epilepsy and that the epileptogenic process in these subjects can last longer than a decade.
authors.forename: F
authors.initials: F
authors.lastname: Pisani
authors.forename: E
authors.initials: E
authors.lastname: Pavlidis
authors.forename: C
authors.initials: C
authors.lastname: Facini
authors.forename: C
authors.initials: C
authors.lastname: La Morgia
authors.forename: C
authors.initials: C
authors.lastname: Fusco
authors.forename: G
authors.initials: G
authors.lastname: Cantalupo
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D012307:Risk Factors; D012640:Seizures / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D020521:Stroke / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology