title: Primary Sarcomas of Thyroid Gland-Series of Three Cases with Brief Review of Spindle Cell Lesions of Thyroid.
abstract: Primary Malignant Fibrous Histiocytoma (MFH-T) and Leiomyosarcoma (LMS-T) of the thyroid gland are extremely rare tumors. Very few cases have been reported in the literature. Both entities occur more commonly in women than men. The closest clinical and histological differential diagnosis is anaplastic carcinoma of thyroid. We present three cases of rare primary sarcomas of thyroid gland. Case-1 was a 63-year-old woman and Case-2 was a 52-year-old woman. Both of them presented with a rapidly increasing thyroid mass clinically mimicking anaplastic carcinoma (AC-T). Both the patients developed pulmonary metastasis and succumbed to the illness soon after the diagnosis of MFH-T was made. Case 3 was 65-year-old woman with neck swelling since six months diagnosed as LMS-T. The present communication adds three new cases to the literature on sarcomas of thyroid gland with an emphasis on differential diagnosis of spindle cell lesions of thyroid. MFH-T and LMS-T needs to be differentiated from AC-T, metastatic sarcomas, spindle cell variant of medullary carcinoma, synovial sarcoma, fibrosarcoma; final diagnosis rests on histopathology and immunohistochemistry.
authors.affiliation: Senior Resident, Department of Pathology, Maulana Azad Medical College , Delhi, India .
authors.forename: Amita Jain
authors.initials: AJ
authors.lastname: Gupta
authors.affiliation: Assistant Professor, Department of Pathology, Maulana Azad Medical College , Delhi, India .
authors.forename: Meeta
authors.initials: M
authors.lastname: Singh
authors.affiliation: Senior Resident, Department of Pathology, Maulana Azad Medical College , Delhi, India .
authors.forename: Poonam
authors.initials: P
authors.lastname: Rani
authors.affiliation: Professor, Department of Pathology, Maulana Azad Medical College , Delhi, India .
authors.forename: Nita
authors.initials: N
authors.lastname: Khurana
authors.affiliation: Professor, Department of Surgery, Maulana Azad Medical College , Delhi, India .
authors.forename: Anurag
authors.initials: A
authors.lastname: Mishra
keywords: Leiomyosarcoma thyroid; Malignant fibrous histiocytoma thyroid; Sarcoma thyroid; Thyroid mass lesion