title: Drug Resistance in Newly Presenting and Previously Treated Tuberculosis Patients in Guangxi Province, People's Republic of China.
abstract: Drug-resistant Mycobacterium tuberculosis strains are a major threat to the control of tuberculosis (TB), but the prevalence of drug-resistant TB is still unknown in the southern ethnic region of China. A cluster-randomized sampling method was used to include the study population. Isolates were tested for resistance to 6 antituberculosis drugs, and genotyped to identify Beijing strains. Overall, 11.3% (139/1229) of new cases and 33.0% (126/382) of retreated cases had drug-resistant tuberculosis. Multiple previous TB treatment episodes and multiple treatment interruptions were risk factors for both drug-resistant and multidrug-resistant TB among retreated cases. A total of 53.2% of the patients were infected with a Beijing strain of M tuberculosis. Infection with a Beijing strain was significantly associated with drug resistance among new cases (odds ratio, 1.44; 95% CI, 1.01-2.07). Novel strategies to rapid diagnosis and effective treatment are urgently needed to prevent the development of drug resistance.
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Zhao
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Lin
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Feiying
authors.initials: F
authors.lastname: Liu
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Shuhai
authors.initials: S
authors.lastname: Huang
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Yingkun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Minying
authors.initials: M
authors.lastname: Huang
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: 2 National Center for TB Control and Prevention, Chinese Center for Disease Control and Prevention. Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: 1 Guangxi Center for Disease Control and Prevention.Nanning, Guangxi, China.
authors.forename: Rushu
authors.initials: R
authors.lastname: Lan
authors.affiliation: 2 National Center for TB Control and Prevention, Chinese Center for Disease Control and Prevention. Beijing, China.
authors.forename: Yanlin
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D015995:Prevalence; D012008:Recurrence; D012307:Risk Factors; D014376:Tuberculosis / Q000188:drug therapy*; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: Beijing genotype; MDR-TB; drug-resistant; ethnic region; tuberculosis