title: The impact of co-morbidity in childhood cystic fibrosis.
abstract: A number of risk factors have been identified for deterioration of lung disease in children with Cystic Fibrosis (CF), and current management strategies are based on the prevention and treatment of such elements. Further challenge ensues when a patient has co-morbid disease in addition to CF, particularly when faced with rapidly deteriorating pulmonary status. It is difficult to measure the contribution of other pathologies to this decline and optimisation of both CF care and co-morbidity is paramount. This review explores the challenges faced when treating children with CF and co-morbid conditions, focussing on gastroesophageal reflux disease pre- and post-lung transplantation.
authors.affiliation: The Royal London Hospital, Barts Health NHS Trust, London, UK. Electronic address: julieduncan@doctors.org.uk.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Duncan
authors.affiliation: The Royal London Hospital, Barts Health NHS Trust, London, UK.
authors.forename: Sarah M N
authors.initials: SMN
authors.lastname: Brown
mesh_terms: D002648:Child; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000601:surgery; D005764:Gastroesophageal Reflux / Q000453:epidemiology*; D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D059035:Perioperative Period; D012307:Risk Factors
keywords: Co-morbid disease; Cystic Fibrosis; Gastroesophageal reflux disease; Paediatric Lung Transplantation