title: The Effect of Tofogliflozin Treatment on Postprandial Glucose and Lipid Metabolism in Japanese Men With Type 2 Diabetes: A Pilot Study.
abstract: BACKGROUND
  Postprandial hyperglycemia and hyperlipidemia are highly related to the development of atherosclerosis. Sodium/glucose cotransporter-2 (SGLT2) inhibitors have attracted attention as a new class of anti-diabetic agents for the treatment of type 2 diabetes. We investigated the effect of tofogliflozin on postprandial glucose and lipid metabolism in Japanese male patients with type 2 diabetes.
  
  
  METHODS
  Ten Japanese men with type 2 diabetes (average age 66.3 years) were orally administered tofogliflozin (20 mg per day) for 8 weeks followed by a subsequent 8 weeks of washout of the agent. At 0, 8 and 16 weeks, postprandial metabolic parameters were measured at 0, 60 and 120 min after cookie ingestion.
  
  
  RESULTS
  There were significant reductions in body weight and body mass index at 8 weeks. There was a reduction in HbA1c at 8 weeks, which returned to pretreatment levels at 16 weeks. Serum insulin levels did not change during the entire study period under either fasting or postprandial state. The area under the curve of plasma glucagon significantly increased at 8 weeks. There were no changes in lipid and lipoprotein levels either in fasting or postprandial state except for tendency toward reduction in postprandial triglycerides at 8 weeks and increase in HDL-C at 16 weeks.
  
  
  CONCLUSIONS
  Tofogliflozin treatment causes an improvement of postprandial glucose metabolism but not considerable postprandial lipid metabolism.
authors.affiliation: Kakuda Clinic, Takamatsu Na15-1, Kahoku, Ishikawa 929-1215, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kakuda
authors.affiliation: Department of General Medicine, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: Junji
authors.initials: J
authors.lastname: Kobayashi
authors.affiliation: Department of Hygiene, Kanazawa Medical University, Ishikawa, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Sakurai
authors.affiliation: Kakuda Clinic, Takamatsu Na15-1, Kahoku, Ishikawa 929-1215, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kakuda
authors.affiliation: Kanazawa Medical University, Ishikawa, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Takekoshi
keywords: Postprandial metabolism; Sodium glucose cotransporter; Tofogliflozin