title: Novel Wavelet Real Time Analysis of Neurovascular Coupling in Neonatal Encephalopathy.
abstract: Birth asphyxia constitutes a major global public health burden for millions of infants, despite hypothermia therapy. There is a critical need for real time surrogate markers of therapeutic success, to aid in patient selection and/or modification of interventions in neonatal encephalopathy (NE). This is a proof of concept study aiming to quantify neurovascular coupling (NVC) using wavelet analysis of the dynamic coherence between amplitude-integrated electroencephalography (aEEG) and near-infrared spectroscopy in NE. NVC coupling is assessed by a wavelet metric estimation of percent time of coherence between NIRS SctO2and aEEG for 78 hours after birth. An abnormal outcome was predefined by a Bayley III score <85 by 18-24 m. We observed high coherence, intact NVC, between the oscillations of SctO2and aEEG in the frequency range of 0.00025-0.001 Hz in the non-encephalopathic newborns. NVC coherence was significantly decreased in encephalopathic newborns who were cooled vs. non-encephalopathic controls (median IQR 3[2-9] vs.36 [33-39]; p < 0.01), and was significantly lower in those with abnormal 24 months outcomes relative to those with normal outcomes (median IQR 2[1-3] vs 28[19-26], p = 0.04). Wavelet coherence analysis of neurovascular coupling in NE may identify infants at risk for abnormal outcomes.
authors.affiliation: Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Lina F
authors.initials: LF
authors.lastname: Chalak
authors.affiliation: Department of Bioengineering, University of Texas at Arlington, Arlington, TX, USA.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Tian
authors.affiliation: Department of Clinical sciences Statistics, UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Beverley
authors.initials: B
authors.lastname: Adams-Huet
authors.affiliation: Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Vasil
authors.affiliation: Brown University, Providence, RI, USA.
authors.forename: Abbot
authors.initials: A
authors.lastname: Laptook
authors.affiliation: Department of internal medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tarumi
authors.affiliation: Department of internal medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
mesh_terms: D019540:Area Under Curve; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D000069336:Neurovascular Coupling; D010100:Oxygen / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors; D058067:Wavelet Analysis
chemical_list: D010100:Oxygen