title: Direct C-H Functionalization of Pyridine via a Transient Activator Strategy: Synthesis of 2,6-Diarylpyridines.
abstract: A Pd-catalyzed highly selective direct diarylation of pyridines has been developed using a transient activator strategy. Both (MeO)2SO2and Cu2O are required for this transformation. The in situ generated N-methylpyridinium salt can be arylated at both 2- and 6-positions under the cooperative Pd/Cu catalysis. A subsequent N-demethylation then gives the 2,6-diarylpyridines. This protocol provides a novel synthetic route for the symmetric 2,6-diarylpyridines.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: Analytical and Testing Center, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Chunchun
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Changzhen
authors.initials: C
authors.lastname: Yin
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Maoshen
authors.initials: M
authors.lastname: Sun
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Haiyan
authors.identifier: 0000-0002-7185-2062
authors.initials: H
authors.lastname: Fu
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Maolin
authors.initials: M
authors.lastname: Yuan
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Ruixiang
authors.identifier: 0000-0003-0756-3722
authors.initials: R
authors.lastname: Li
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Chen