title: Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities.
abstract: BACKGROUND
  Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms.
  
  
  OBJECTIVE
  This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts.
  
  
  METHODS
  Eighteen non-MF/SS PCL, four SCL, and two POL with available tissue for morphology and immunophenotypic assessment were reclassified according to the 2005-WHO/EORTC and 2016-WHO classifications.
  
  
  RESULTS
  Non-MF/SS PCLs were primarily of T-cell origin (61%) where CD30+ lymphoproliferative disorders predominated, followed by Epstein-Barr virus-induced lymphomas, and peripheral T-cell lymphomas, not otherwise specified. Primary cutaneous B-cell lymphomas (BCL) were primarily of follicle center cell origin followed by postgerminal lymphomas of the diffuse large BCL variety.
  
  
  CONCLUSIONS
  Most non-MF/SS PCL, SCL, and POL can be adequately categorized according to the 2005-WHO/EORTC and 2016-WHO classification systems, even when dealing with clinically atypical cases. The relative frequencies in our cohort hold closer similarities to Asian registries than from those of Europe/USA, supporting the concept of individual and/or racial susceptibility, and the notion of geographical variances in the rate of lymphomas. In particular, such disparity may arise from viral-induced lymphomas which might show partial geographical restriction.
authors.affiliation: Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico.
authors.forename: Amparo
authors.initials: A
authors.lastname: Hernández-Salazar
authors.affiliation: Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico.
authors.forename: Jorge Andrés
authors.initials: JA
authors.lastname: García-Vera
authors.affiliation: Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico; Department of Dermatology, Cutaneous Hematopathology Clinic, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico.
authors.forename: Yann
authors.initials: Y
authors.lastname: Charli-Joseph
authors.affiliation: Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Ortiz-Pedroza
authors.affiliation: Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico.
authors.forename: Silvia
authors.initials: S
authors.lastname: Méndez-Flores
authors.affiliation: Department of Dermatology, Dermatology Private Practice, Hospital Médica Sur, City, Mexico.
authors.forename: Rocío
authors.initials: R
authors.lastname: Orozco-Topete
authors.affiliation: Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico.
authors.forename: Ana Lilia
authors.initials: AL
authors.lastname: Morales-Leyte
authors.affiliation: Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico.
authors.forename: Judith
authors.initials: J
authors.lastname: Domínguez-Cherit
authors.affiliation: Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, City, Mexico; Division of Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico.
authors.forename: Carmen
authors.initials: C
authors.lastname: Lome-Maldonado
keywords: Primary cutaneous lymphomas; primary oral lymphomas; secondary cutaneous lymphomas