title: Plasma pharmacokinetics and muscle residue dynamics of mebendazole in Carassius auratus.
abstract: Mebendazole is approved for use in aquatic animals and is widely used in Chinese aquaculture. We developed a pharmacokinetic and residue analysis for mebendazole levels in the goldfish (Carassius auratus). Plasma and muscle samples of C. auratus were taken after oral administration of 10 mg/kg mebendazole. The maximal drug plasma concentration of 0.55 mg/L was achieved at 48 hr and then declined with the elimination half-life (T1/2β) of 7.99 hr. Administration of 10 mg/kg by oral gavage for 5 successive days resulted in a peak mebendazole concentration of 0.70 mg/kg in muscle at 96 hr after the last dose. The drug was then eliminated at a relatively slow rate from muscle with T1/2βof 68.41 hr. There was no detectable mebendazole in any muscle samples at 24 days postadministration. The AUClastin plasma and muscle was 19.42 and 105.33 mg hr/L, respectively. These data provide information for dosage recommendations and withdrawal time determinations for mebendazole use in aquariums.
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.|College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: X
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.|College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: College of Veterinary Medicine, Hunan Agriculture University, Changsha, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China.|College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: Z
authors.identifier: http://orcid.org/0000-0001-6486-9600
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D006054:Goldfish / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D008463:Mebendazole / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D018482:Muscle, Skeletal / Q000737:chemistry
chemical_list: D000969:Antinematodal Agents; D008463:Mebendazole
keywords: 
  Carassius auratus
  ; mebendazole; pharmacokinetics; residue analysis