title: Imaginal disc regeneration takes flight.
abstract: Drosophila imaginal discs, the larval precursors of adult structures such as the wing and leg, are capable of regenerating after damage. During the course of regeneration, discs can sometimes generate structures that are appropriate for a different type of disc, a phenomenon termed transdetermination. Until recently, these phenomena were studied by physically fragmenting discs and then transplanting them into the abdomens of adult female flies. This field has experienced a renaissance following the development of genetic ablation systems that can damage precisely defined regions of the disc without the need for surgery. Together with more traditional approaches, these newer methods have generated many novel insights into wound healing, the mechanisms that drive regenerative growth, plasticity during regeneration and systemic effects of tissue damage and regeneration.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA. Electronic address: ikh@berkeley.edu.
authors.forename: Iswar K
authors.initials: IK
authors.lastname: Hariharan
authors.affiliation: Departament de Genètica, Facultat de Biologia and Institute de Biomedicina (IBUB), Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain. Electronic address: fserras@ub.edu.
authors.forename: Florenci
authors.initials: F
authors.lastname: Serras
mesh_terms: D000818:Animals; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology / Q000254:growth & development* / Q000502:physiology*; D005123:Eye / Q000166:cytology / Q000254:growth & development; D060227:Imaginal Discs / Q000502:physiology*; D007814:Larva / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D014921:Wings, Animal / Q000166:cytology / Q000254:growth & development
chemical_list: D029721:Drosophila Proteins