title: Antibacterial Activity of Ethanolic Extract of Cinnamon Bark, Honey, and Their Combination Effects against Acne-Causing Bacteria.
abstract: Propionibacterium acnesandStaphylococcus epidermidisare the major skin bacteria that cause the formation of acne. The present study was conducted to investigate antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination against acne bacteria. The antibacterial activity of extract of cinnamon bark and honey were investigated againstP. acnesandS. epidermidisusing disc diffusion. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were attained using Clinical and Laboratory Standard Institute (CLSI) methods. The interaction between cinnamon bark extract and honey was determined using a checkerboards method. The results showed that the MICs of cinnamon bark extract and honey againstP. acnewere 256 µg/mL and 50%v/v, respectively, while those againstS. epidermidiswere 1024 µg/mL and 50%v/v, respectively. The MBC of cinnamon bark extract againstP. acnesandS. epidermidiswere more than 2048 µg/mL, whereas the MBC for honey againstP. acnesandS. epidermidiswere 100%. The combination of cinnamon bark extract and honey againstP. acnesandS. epidermidisshowed additive activity with a fractional inhibitory concentration index (FICI) value of 0.625. Therefore, the combination of cinnamon bark extract and honey has potential activity against acne-causing bacteria.
authors.affiliation: School of Pharmacy, Bandung Institute of Technology, Labtek VII, JL. Ganesha 10, Bandung 40132, West Java, Indonesia. elin_julianti@fa.itb.ac.id.
authors.forename: Elin
authors.initials: E
authors.lastname: Julianti
authors.affiliation: School of Pharmacy, Bandung Institute of Technology, Labtek VII, JL. Ganesha 10, Bandung 40132, West Java, Indonesia. kasturi_mas@yahoo.com.
authors.forename: Kasturi K
authors.initials: KK
authors.lastname: Rajah
authors.affiliation: School of Pharmacy, Bandung Institute of Technology, Labtek VII, JL. Ganesha 10, Bandung 40132, West Java, Indonesia. irda@fa.itb.ac.id.
authors.forename: Irda
authors.initials: I
authors.lastname: Fidrianny
keywords: additive activity; antibacterial activity; checkerboards method; cinnamon; honey