title: Developing species sensitivity distributions for metallic nanomaterials considering the characteristics of nanomaterials, experimental conditions, and different types of endpoints.
abstract: A species sensitivity distribution (SSD) for engineered nanomaterials (ENMs) ranks the tested species according to their sensitivity to a certain ENM. An SSD may be used to estimate the maximum acceptable concentrations of ENMs for the purpose of environmental risk assessment. To construct SSDs for metal-based ENMs, more than 1800 laboratory derived toxicity records of metallic ENMs from >300 publications or open access scientific reports were retrieved. SSDs were developed for the metallic ENMs grouped by surface coating, size, shape, exposure duration, light exposure, and different toxicity endpoints. It was found that PVP- and sodium citrate- coatings enhance the toxicity of Ag ENMs as concluded from the relevant SSDs. For the Ag ENMs with different size ranges, differences in behavior and/or effect were only observed at high exposure concentrations. The SSDs of Ag ENMs separated by both shape and exposure duration were all nearly identical. Crustaceans were found to be the most vulnerable group to metallic ENMs. In spite of the uncertainties of the results caused by limited data quality and availability, the present study provided novel information about building SSDs for distinguished ENMs and contributes to the further development of SSDs for metal-based ENMs.
authors.affiliation: Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands. Electronic address: chen@cml.leidenuniv.nl.
authors.forename: Guangchao
authors.initials: G
authors.lastname: Chen
authors.affiliation: Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands; National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
authors.forename: Willie J G M
authors.initials: WJGM
authors.lastname: Peijnenburg
authors.affiliation: Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands.
authors.forename: Yinlong
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Institute of Environmental Sciences, Leiden University, Leiden, The Netherlands.
authors.forename: Martina G
authors.initials: MG
authors.lastname: Vijver
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002951:Citrates / Q000737:chemistry; D003445:Crustacea / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D005399:Fishes; D008027:Light; D053768:Metal Nanoparticles / Q000633:toxicity*; D058086:Microalgae / Q000187:drug effects; D009348:Nematoda / Q000187:drug effects; D010271:Parasites / Q000187:drug effects; D018570:Risk Assessment; D000077559:Sodium Citrate; D013045:Species Specificity; D018675:Toxicity Tests; D015003:Yeasts / Q000187:drug effects
chemical_list: D002951:Citrates; D004785:Environmental Pollutants; D000077559:Sodium Citrate
keywords: Ecotoxicity; Engineered nanomaterials; Modeling; Risk assessment; Species sensitivity distributions