title: HHV8/KSHV-Positive Lymphoproliferative Disorders and the Spectrum of Plasmablastic and Plasma Cell Neoplasms: 2015 SH/EAHP Workshop Report-Part 3.
abstract: OBJECTIVE
  The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review immunodeficiency-related lymphoproliferative disorders with plasmablastic and plasma cell differentiation.
  
  
  METHODS
  The workshop panel reviewed human herpes virus 8 (HHV8)/Kaposi sarcoma herpesvirus (KSHV)-associated lesions and other lesions exhibiting plasma cell differentiation, including plasmablastic proliferations with features of myeloma/plasmacytoma, plasmablastic neoplasms presenting in extranodal sites and effusion-based lymphomas, and rendered a consensus diagnosis.
  
  
  RESULTS
  The spectrum of HHV8/KSHV-associated proliferations ranged from multicentric Castleman disease (MCD) to MCD with plasmablastic aggregates to HHV8+ diffuse large B-cell lymphoma and germinotrophic lymphoproliferative disorder. Comparisons across effusion-based lymphomas with and without HHV8/KSHV and plasmablastic lymphomas in immunodeficient and immunocompetent patients were discussed.
  
  
  CONCLUSIONS
  The presence or absence of HHV8/KSHV is a defining feature in disorders associated with Castleman disease, although their differential diagnosis and recognition of progression may be challenging. Plasmablastic proliferations overlap with myeloma/plasmacytoma as well as extranodal and effusion-based lymphomas. The involvement of Epstein-Barr virus is typically variable.
authors.affiliation: From the Weill Medical College of Cornell University, New York, NY.
authors.forename: Amy
authors.initials: A
authors.lastname: Chadburn
authors.affiliation: University of California Los Angeles Medical Center, Los Angeles.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Said
authors.affiliation: Stanford University School of Medicine, Stanford, CA.
authors.forename: Dita
authors.initials: D
authors.lastname: Gratzinger
authors.affiliation: Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: John K C
authors.initials: JK
authors.lastname: Chan
authors.affiliation: VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Daphne
authors.initials: D
authors.lastname: de Jong
authors.affiliation: National Institutes of Health, Bethesda, MD.
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Jaffe
authors.affiliation: Stanford University School of Medicine, Stanford, CA.
authors.forename: Yasodha
authors.initials: Y
authors.lastname: Natkunam
authors.affiliation: University of Leeds, Leeds, UK.
authors.forename: John R
authors.initials: JR
authors.lastname: Goodlad
mesh_terms: D000328:Adult; D000368:Aged; D004493:Education; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D019288:Herpesvirus 8, Human; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000473:pathology* / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D054219:Neoplasms, Plasma Cell / Q000175:diagnosis / Q000473:pathology* / Q000821:virology
keywords: Germinotropic lymphoproliferative disorder; HHV8; KSHV; Multicentric Castleman disease; Plasmablastic lymphoma; Primary effusion lymphoma