title: Design and Scaling Up of Microchemical Systems: A Review.
abstract: The past two decades have witnessed a rapid development of microreactors. A substantial number of reactions have been tested in microchemical systems, revealing the advantages of controlled residence time, enhanced transport efficiency, high product yield, and inherent safety. This review defines the microchemical system and describes its components and applications as well as the basic structures of micromixers. We focus on mixing, flow dynamics, and mass and heat transfer in microreactors along with three strategies for scaling up microreactors: parallel numbering-up, consecutive numbering-up, and scale-out. We also propose a possible methodology to design microchemical systems. Finally, we provide a summary and future prospects.
authors.affiliation: The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; email: gsluo@tsinghua.edu.cn.|Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Jisong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; email: gsluo@tsinghua.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Teixeira
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
authors.forename: Klavs F
authors.initials: KF
authors.lastname: Jensen
authors.affiliation: The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China; email: gsluo@tsinghua.edu.cn.
authors.forename: Guangsheng
authors.initials: G
authors.lastname: Luo
mesh_terms: D004867:Equipment Design; D057446:Hydrodynamics; D056656:Lab-On-A-Chip Devices; D046208:Microchip Analytical Procedures / Q000379:methods*; D013814:Thermal Conductivity
keywords: microfluidics; microreactor; mixing; reaction; scaling up; transport