title: Haplotype structure and copy number polymorphism of the beta-defensin 7 genes in diverse chicken breeds.
abstract: Beta-defensins is a family of avian peptides related to the innate immune system. Copy number variation was recently reported for the avian beta-defensin 7 gene (AvBD7) between the highly inbred Leghorn and Fayoumi lines. Here, we examined copy number variants in 35 different chicken breeds and found that 31 of them have at least the same representation of the duplicated AvBD7 allele. We also found haplotypes upstream of the AvBD6 regions that are strongly linked to the AvBD7 duplication. We observed a strong linkage disequilibrium spanning of the upstream region of the AvBD6 gene, with two SNPs being flanking markers to detect duplication of the AvBD7.
authors.affiliation: Department of Veterinary Pathobiology, Texas A & M University, College Station, 77843, TX, USA.
authors.forename: M O
authors.initials: MO
authors.lastname: Lee
authors.affiliation: School of Biosciences, University of Kent, CT2 7NJ, Canterbury, UK.
authors.forename: M N
authors.initials: MN
authors.lastname: Romanov
authors.affiliation: Russian Research Institute of Farm Animal Genetics and Breeding (RRIFAGB), Pushkin, 196601, St. Petersburg, Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Plemyashov
authors.affiliation: Russian Research Institute of Farm Animal Genetics and Breeding (RRIFAGB), Pushkin, 196601, St. Petersburg, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Dementieva
authors.affiliation: Russian Research Institute of Farm Animal Genetics and Breeding (RRIFAGB), Pushkin, 196601, St. Petersburg, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Mitrofanova
authors.affiliation: Russian Research Institute of Farm Animal Genetics and Breeding (RRIFAGB), Pushkin, 196601, St. Petersburg, Russia.
authors.forename: O Y
authors.initials: OY
authors.lastname: Barkova
authors.affiliation: Department of Veterinary Pathobiology, Texas A & M University, College Station, 77843, TX, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Womack
mesh_terms: D000818:Animals; D001947:Breeding; D002645:Chickens / Q000235:genetics*; D056915:DNA Copy Number Variations; D020440:Gene Duplication; D006239:Haplotypes; D015810:Linkage Disequilibrium; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide; D023083:beta-Defensins / Q000235:genetics*
chemical_list: D023083:beta-Defensins
keywords: copy number variants; haplotype; linkage disequilibrium; poultry breeds