title: A Clinical and Radiological Approach to the Management of Benign Mesenchymal Sinonasal Tumors.
abstract: OBJECTIVE
  Benign mesenchymal sinonasal neoplasms (BMSN) are rare and histologically heterogeneous. Differential diagnosis, appropriate management, and outcome are still a matter of debate. The aim of this study is to provide evidence for further refinement of assessment and treatment in the future.
  
  
  METHODS
  We retrospectively reviewed data on 93 patients with neuroradiologically verified BMSN treated at our university reference center during the past 22 years.
  
  
  RESULTS
  The most frequent BMSN recorded in our cohort was osteoma of the frontal sinus. Only one-third of the patients affected were symptomatic at initial presentation. The 2 other common fibro-osseous tumor entities, fibrous dysplasia and ossifying fibroma, were confirmed in 12 and 6 patients, respectively. Patients with soft tissue tumor entities such as hemangioma, glomangiopericytoma, angiofibroma, and hamartoma were all symptomatic and underwent surgical resection.
  
  
  CONCLUSIONS
  Understanding and recognizing the spectrum of appearances of benign mesenchymal sinonasal tumors will improve patient assessment and clinical management. The pathognomonic neuroradiological signs of a particular tumor entity should be actively sought as the neuroradiological features may be the diagnostic clues. Computed tomography and magnetic resonance imaging play complementary roles in identifying the morphological details and locoregional staging of benign mesenchymal sinonasal tumors.
authors.affiliation: University Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital Bern, University Hospital and University of Bern, Bern, Switzerland.
authors.forename: Lukas
authors.initials: L
authors.lastname: Anschuetz
authors.forename: Melanie
authors.initials: M
authors.lastname: Buchwalder
authors.forename: Matthias
authors.initials: M
authors.lastname: Dettmer
authors.forename: Marco D
authors.initials: MD
authors.lastname: Caversaccio
authors.forename: Franca
authors.initials: F
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D015331:Cohort Studies; D005260:Female; D018214:Fibroma, Ossifying / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008637:Mesenchymoma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010016:Osteoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D035583:Rare Diseases; D012189:Retrospective Studies; D013557:Switzerland; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Benign mesenchymal sinonasal neoplasms; Computed tomography; Fibrous dysplasia; Magnetic resonance imaging; Osteoma; Sinonasal mass