title: Neuroprotective and Antiamnesic Effects ofMitragyna inermisWilld (Rubiaceae) on Scopolamine-Induced Memory Impairment in Mice.
abstract: Aim. To assess memory improvement and neuroprotective and antioxidant effects ofMitragyna inermis(M. inermis) leaf decoction on the central nervous system.Methodology. Leaf decoction ofM. inermiswas tested on learning and memory in normal and scopolamine-induced cognitive impairment in mice using memory behavioral tests such as the Morris water maze, object recognition task, and elevated plus maze. Oxidative stress enzymes-catalase, superoxide dismutase, and the thiobarbituric acid reactive substance, a product of lipid peroxidation-were quantified. In each test, mice 18 to 25 g were divided into groups of 5.Results. The extract reversed the effects of scopolamine in mice. The extract significantly increased discrimination index in the object recognition task test and inflexion ratio in the elevated plus maze test. The times spent in target quadrant in MWM increased while the transfer latency decreased in mice treated byM. inermisat the dose of 196.5 mg/kg. The activity levels of superoxide dismutase and catalase were significantly increased, whereas the thiobarbituric acid reactive substance was significantly decreased after 8 consecutive days of treatment withM. inermisat the dose of 393 mg/kg.Conclusion. These results suggest thatM. inermisleaf extract possess potential antiamnesic effects.
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
authors.forename: David Bougolla
authors.identifier: 0000-0003-1415-5313
authors.initials: DB
authors.lastname: Pahaye
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon; Institute of Mines and Petroleum Industries, University of Maroua, P.O. Box 46, Maroua, Cameroon.
authors.forename: Elisabeth Ngo
authors.initials: EN
authors.lastname: Bum
authors.affiliation: Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.
authors.forename: Germain Sotoing
authors.initials: GS
authors.lastname: Taïwé
authors.affiliation: Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
authors.forename: Gwladys Temkou
authors.initials: GT
authors.lastname: Ngoupaye
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
authors.forename: Neteydji
authors.initials: N
authors.lastname: Sidiki
authors.affiliation: Higher Teachers' Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon.
authors.forename: Fleur Clarisse Okomolo
authors.initials: FC
authors.lastname: Moto
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon; Department of Zoology and Animal Physiology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.
authors.forename: Nadège
authors.initials: N
authors.lastname: Kouemou
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
authors.forename: Stephanie Jacqueline Kameni
authors.initials: SJ
authors.lastname: Njapdounke
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
authors.forename: Gisele
authors.initials: G
authors.lastname: Nkantchoua
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon; Department of Animal Biology and Physiology, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
authors.forename: Antoine
authors.identifier: 0000-0003-4358-6593
authors.initials: A
authors.lastname: Kandeda
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon; Higher Teachers' Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon.
authors.forename: Jean Pierre Omam
authors.initials: JP
authors.lastname: Omam
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
authors.forename: Veronique
authors.initials: V
authors.lastname: Mairaira
authors.affiliation: Department of Biological Science, Faculty of Sciences, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon; Center of Medical Research, Institute of Medical Research and Medical Plants Studies, P.O. Box 6163, Yaoundé, Cameroon.
authors.forename: Josiane Lucie
authors.identifier: 0000-0002-5580-3551
authors.initials: JL
authors.lastname: Ojong
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D032065:Mitragyna / Q000737:chemistry*; D018696:Neuroprotective Agents / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D028321:Plant Preparations / Q000494:pharmacology*; D012601:Scopolamine
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D028321:Plant Preparations; D012601:Scopolamine