title: Synthesis of Some Unique Carbamate Derivatives bearing 2-Furoyl-1-piperazine as a Valuable Therapeutic Agents.
abstract: The aim of the research work was to synthesize different biologically active carbamate derivatives bearing 2-furoyl-1-piperazine and having modest toxicity. The synthesis was completed as a multiple sequence. The structural confirmation of all the synthesized compounds was obtained by EI-MS, IR and 1H-NMR spectral data. The enzyme inhibition and antibacterial potential of the synthesized compounds was evaluated. To find the utility of the prepared compounds as possible therapeutic agents their cytotoxicity was also checked. All the compounds were active against acetylcholinesterase enzyme, especially 12 and 14 showed very good inhibitory potential relative to Eserine, a reference standard. Almost all the compounds showed good activities against both Gram-positive and Gram-negative bacterial strains.
authors.forename: Athar
authors.initials: A
authors.lastname: Abbasi
authors.forename: Ghulam
authors.initials: G
authors.lastname: Hussain
authors.forename: Aziz Ur
authors.initials: AU
authors.lastname: Rehman
authors.forename: Zahra
authors.initials: Z
authors.lastname: Siddiqui
authors.forename: Adnan Ali
authors.initials: AA
authors.lastname: Shah
authors.forename: Arif
authors.initials: A
authors.lastname: Lodhi
authors.forename: Ali
authors.initials: A
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Qurat Ul
authors.initials: QU
authors.lastname: Ain
authors.forename: Irshad
authors.initials: I
authors.lastname: Ahmad
authors.forename: Rabia
authors.initials: R
authors.lastname: Malik
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shahid
authors.forename: Zahid
authors.initials: Z
authors.lastname: Mushtaq
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002091:Butyrylcholinesterase / Q000187:drug effects; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D002219:Carbamates; D010879:Piperazines; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase