title: Lacrimal Sac Tumors--A Review.
abstract: Tumors of the lacrimal sac are rare but their recognition and early management are imperative, as they are locally invasive and potentially life-threatening. Because of their rarity, large clinical studies with statistically significant data on the natural course, management, and prognosis of these neoplasms are unavailable. Current practices are therefore based on a few case series and a small number of isolated case reports. Most tumors are primary and of epithelial origin (60-94%), of which 55% are malignant. Lacrimal sac tumors typically present with epiphora and a palpable mass over the medial canthus and are thus often erroneously diagnosed as chronic dacryocystitis. A full history with clinical and diagnostic workup is essential to plan treatment, which is often multi-disciplinary. Statistically significant associations have been shown with higher tumor staging and size with increased metastatic risk and lower survival rates. Management usually involves complete surgical resection with adjuvant radiotherapy and/or chemotherapy for malignant lesions. Long-term follow-up is required, as recurrences and metastases can occur many years after initial treatment.
authors.affiliation: Department of Cellular Pathology, Royal Liverpool and Broadgreen University Hospital Trust, Liverpool, England.
authors.forename: Yamini
authors.initials: Y
authors.lastname: Krishna
authors.affiliation: Department of Cellular Pathology, Royal Liverpool and Broadgreen University Hospital Trust, Liverpool, England.|Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, England.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Coupland
mesh_terms: D003131:Combined Modality Therapy; D019468:Disease Management; D005134:Eye Neoplasms / Q000145:classification / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007765:Lacrimal Apparatus / Q000473:pathology*; D007766:Lacrimal Apparatus Diseases / Q000145:classification / Q000175:diagnosis / Q000628:therapy
keywords: dacryocystitis; lacrimal sac tumors; secondary nasolacrimal obstruction