title: Polymeric1H MRI Probes for Visualizing Tumor In Vivo.
abstract: Magnetic resonance imaging (MRI) has become a prominent non- or low-invasive imaging technique, providing high-resolution, three-dimensional images as well as physiological information about tissues. Low-molecular-weight Gd-MRI contrast agents (CAs), such as Gd-DTPA (DTPA: diethylenetriaminepentaacetic acid), are commonly used in the clinical diagnosis, while macromolecular Gd-MRI CAs have several advantages over low-molecular-weight Gd-MRI CAs, which help minimize the dose of CAs and the risk of side effects. Accordingly, we developed chiral dendrimer Gd-MRI CAs, which showed high r1values. The association constant values (Ka) of S-isomeric dendrimer CAs to bovine serum albumin (BSA) were higher than those of R-isomeric dendrimer CAs. Besides, based on a totally new concept, we developed13C/15N-enriched multiple-resonance NMR/MRI probes, which realized highly selective observation of the probes and analysis of metabolic reactions of interest. This account summarizes our recent study on developing both chiral dendrimer Gd-MRI CAs, and self-traceable13C/15N-enriched phosphorylcholine polymer probes for early detection of tumors.
authors.affiliation: Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 6158510, JAPAN.
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Research and Educational Unit of Leaders for Integrated Medical Systems, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 6158510, JAPAN.
authors.forename: Yu
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Field of Bioresource Chemistry and Technology, Graduate School of Bioscience and Bioindustry, Tokushima University, 2-1, Minamijosanjima-cho, Tokushima, 7708506, JAPAN.
authors.forename: Hisatsugu
authors.initials: H
authors.lastname: Yamada
authors.affiliation: Professor emeritus, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 6158510, JAPAN.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Aoyama
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry; D019786:Gadolinium DTPA / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000000981:diagnostic imaging*; D010767:Phosphorylcholine / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D050091:Dendrimers; D011108:Polymers; D010767:Phosphorylcholine; D019786:Gadolinium DTPA
keywords: MRI; contrast agent; dendrimer; multiple resonance; phosphorylcholine