title: Pro(moting) the Turnover of Gluconeogenic Enzymes by a New Branch of the N-end Rule Pathway.
abstract: The N-end rule pathway is a set of protein degradation systems that link the in vivo stability of a protein to its N-terminal residue. A recent paper from Alexander Varshavsky's laboratory [1] identifies a new branch of the N-end rule pathway that specifically recognizes the N-terminal Pro residue of key gluconeogenesis enzymes.
authors.affiliation: La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Victoria, Australia. Electronic address: d.dougan@latrobe.edu.au.
authors.forename: David A
authors.initials: DA
authors.lastname: Dougan
mesh_terms: D000818:Animals; D005943:Gluconeogenesis; D005947:Glucose / Q000096:biosynthesis*; D006801:Humans; D008025:Ligases / Q000378:metabolism*
chemical_list: D008025:Ligases; D005947:Glucose
keywords: Gluconeogenesis; N-end rule; Proline; Protein degradation