title: [Clinical and pathological features in IgA nephropathy with IgG deposition in the glomerular mesangial area].
abstract: To investigate the relationship between the clinical and pathological findings in IgA nephropathy with or without IgG deposition in the glomerular mesangial area.
  
  
  
  The data were collected from 122 patients with a diagnosis of IgA nephropathy by renal biopsy in the Third Affiliated Hospital of Southern Medical University between November, 2009 and February, 2016. All the samples were examined by light microscopy, immunofluorescence and electron microscopy. According to the results of immunofluorescence assay, the patients were divided into IgA group (n=63) and IgA-IgG group (n=59). The pathological classification of IgA nephropathy was analyzed according to Oxford classification and Lee's classification. The clinical and pathological findings were compared between the two groups.
  
  
  
  Compared with the patients with IgA nephropathy but without IgG deposition, patients with IgA nephropathy with IgG deposition had higher serum creatinine, higher 24-h urine protein, higher blood uric acid, higher triglyceride levels (P<0.05) and lower eGFR (P<0.05); more of these patients were in Lee's grade IV-V, had renal tubular atrophy and/or interstitial fibrosis, and had MEST scores more than 3 (P<0.05).
  
  
  
  Patients with IgA nephropathy with IgG deposition in the glomerular mesangial have severer clinical symptoms and more serious pathological changes. Measures should be taken to control IgG deposition in patients with IgA nephropathy to delay the progress of the disease.
authors.affiliation: Institute of Nephrology and Urology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.E-mail: xuxiaomeng@foxmail.com.
authors.forename: Xiao-Meng
authors.initials: XM
authors.lastname: Xu
authors.forename: Shuang-Shuang
authors.initials: SS
authors.lastname: Zhu
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Wang
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Shao
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.forename: Jia-Min
authors.initials: JM
authors.lastname: Li
authors.forename: Hong-Lei
authors.initials: HL
authors.lastname: Wang
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Li
authors.forename: He-Qun
authors.initials: HQ
authors.lastname: Zou
mesh_terms: D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D005920:Glomerular Mesangium / Q000473:pathology*; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007668:Kidney / Q000503:physiopathology*; D011507:Proteinuria / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D007074:Immunoglobulin G; D014280:Triglycerides; D014527:Uric Acid; D003404:Creatinine