title: Insights from Ultrahigh Field Imaging in Multiple Sclerosis.
abstract: Ultrahigh-field (≥7 T) magnetic resonance (MR) imaging is being used at many leading academic medical centers to study neurologic disorders. The improved spatial resolution and anatomic detail are due to the increase in signal-to-noise and contrast-to-noise ratio at higher magnetic field strengths. Ultrahigh-field MR imaging improves multiple sclerosis (MS) lesion detection, with particular sensitivity to detect cortical lesions. The increase in magnetic susceptibility effects inherent to ultrahigh field can be used to detect pathologic features of MS lesions, including a central vein, potentially useful for diagnostic considerations, and heterogeneity among MS lesions, potentially useful in determining lesion outcomes.
authors.affiliation: Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Medical Center Boulevard, 10 Center Drive, MSC 1400, Bethesda, MD 20892, USA.
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Schindler
authors.affiliation: Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Medical Center Boulevard, 10 Center Drive, MSC 1400, Bethesda, MD 20892, USA.
authors.forename: Pascal
authors.initials: P
authors.lastname: Sati
authors.affiliation: Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Medical Center Boulevard, 10 Center Drive, MSC 1400, Bethesda, MD 20892, USA. Electronic address: reichds@ninds.nih.gov.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Reich
mesh_terms: D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000473:pathology*
keywords: MR imaging; Multiple sclerosis; Ultrahigh field imaging