title: Thermal characteristics of non-biological vessel phantoms for treatment of varicose veins using high-intensity focused ultrasound.
abstract: The ultrasonic treatment of varicose veins uses high-intensity focused ultrasound, in which a blood vessel is contracted by converting acoustic energy into thermal energy. In this study, we propose a phantom of varicose veins that can be applied for the efficient evaluation of ultrasonic treatment in varicose veins. The proposed phantom consisted of glycerol base tissue equivalent material, vessel mimic tube, and blood mimic substances. The vessel mimic tube was placed inner glycerol phantom and it was filled with blood mimic substances. Blood-mimicked substances are prepared by adjusting the concentration of the glycerol solution to be similar to the acoustic properties of the blood, and vessel-mimicking materials are selected by measuring acoustic properties and thermal shrinkage of various materials in a heat-shrinkable tube. The blood vessels surrounding the tissue are replaced with the phantom similar to glycerol-based organization, and venous blood flow is implemented using a DC motor. The heating characteristics according to the ultrasonic wave using the manufactured varicose veins phantom were evaluated. As the sound wave irradiation time and power increased, the contractility of the vessel mimicking materials and the temperature of the surrounding tissues were increased. When the blood-mimicking material was circulated, the highest temperature in the focused region and the contractility of vessel mimicking materials were reduced under the same conditions as used for sonication. The manufactured phantom may contribute to the treatment of varicose veins and can be used to predict the ultrasonic therapeutic efficiency of varicose veins.
authors.affiliation: Medical Device Evaluation Department, National Institute of Food and Drug Safety Evaluation, Cheongju, Chungcheongbuk-do, Korea.
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Inje University, Gimhae, Kyoungsangnam-do, Korea.
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Radiological Science, International University of Korea, Jinju, Kyoungsangnam-do, Korea.
authors.forename: Si-Cheol
authors.initials: SC
authors.lastname: Noh
authors.affiliation: Department of Biomedical Engineering, Inje University, Gimhae, Kyoungsangnam-do, Korea.
authors.forename: Heung-Ho
authors.identifier: http://orcid.org/0000-0001-8978-0426
authors.initials: HH
authors.lastname: Choi
mesh_terms: D006801:Humans; D006979:Hyperthermia, Induced; D019047:Phantoms, Imaging; D014464:Ultrasonic Therapy; D014648:Varicose Veins / Q000628:therapy*