title: Generating pulsatility by pump speed modulation with continuous-flow total artificial heart in awake calves.
abstract: The purpose of this study was to evaluate the effects of sinusoidal pump speed modulation of the Cleveland Clinic continuous-flow total artificial heart (CFTAH) on hemodynamics and pump flow in an awake chronic calf model. The sinusoidal pump speed modulations, performed on the day of elective sacrifice, were set at ±15 and ± 25% of mean pump speed at 80 bpm in four awake calves with a CFTAH. The systemic and pulmonary arterial pulse pressures increased to 12.0 and 12.3 mmHg (±15% modulation) and to 15.9 and 15.7 mmHg (±25% modulation), respectively. The pulsatility index and surplus hemodynamic energy significantly increased, respectively, to 1.05 and 1346 ergs/cm at ±15% speed modulation and to 1.51 and 3381 ergs/cm at ±25% speed modulation. This study showed that it is feasible to generate pressure pulsatility with pump speed modulation; the platform is suitable for evaluating the physiologic impact of pulsatility and allows determination of the best speed modulations in terms of magnitude, frequency, and profiles.
authors.affiliation: Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. fukamak@ccf.org.
authors.forename: Kiyotaka
authors.identifier: http://orcid.org/0000-0002-4852-8416
authors.initials: K
authors.lastname: Fukamachi
authors.affiliation: Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. karimoj@ccf.org.
authors.forename: Jamshid H
authors.initials: JH
authors.lastname: Karimov
authors.affiliation: Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
authors.forename: Gengo
authors.initials: G
authors.lastname: Sunagawa
authors.affiliation: Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.|R1 Engineering, Cleveland, OH, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Horvath
authors.affiliation: Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Byram
authors.affiliation: Electronics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Barry D
authors.initials: BD
authors.lastname: Kuban
authors.affiliation: Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
authors.forename: Raymond
authors.initials: R
authors.lastname: Dessoffy
authors.affiliation: Department of Cardiothoracic Anesthesiology, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Shiva
authors.initials: S
authors.lastname: Sale
authors.affiliation: Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
authors.forename: Leonard A R
authors.initials: LAR
authors.lastname: Golding
authors.affiliation: Cardiovascular Dynamics Laboratory, Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.|Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Nader
authors.initials: N
authors.lastname: Moazami
mesh_terms: D000818:Animals; D002417:Cattle; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006439:Hemodynamics; D011673:Pulsatile Flow
keywords: Heart-assist devices; Hemodynamics; Implants, experimental; Pulsatile flow; Waveform