title: Minor allele C of rs12807809 polymorphism in NRGN contributes to the severity of psychosis in patients with Schizophrenia in South Indian population.
abstract: Schizophrenia (SCZ) as a severe and complex neuropsychiatric disorder and is characterized by positive symptoms, negative symptoms and cognitive dysfunctions. Genome-wide association studies (GWAS) have identified a strong association between the single nucleotide polymorphism (SNP) rs12807809 upstream of Neurogranin (NRGN) in a European population. This evidence prompted us to conduct an association study among 1005 schizophrenia cases and 1069 controls in a South Indian Population using TaqMan Allelic discrimination method. We observed an association of rs12807809 with SCZ in this study population. Allele frequencies and genotype frequencies of rs12807809 showed significant differences between cases and control subjects [p=0.0019; OR=0.69; 95% CI=(0.55-0.87)] and (p=0.0062). Further Genotype-Phenotype correlation revealed a moderate association of rs12807809 with flat affect (p=0.039) and Hallucinations (p=0.012). The ancestral non-risk C allele contributes to the severity of psychosis (p=0.039) in this population.
authors.affiliation: Department of Genetics, University of Madras, Dr. ALM PG Institute of Basic Medical Sciences, Taramani Campus, Chennai, 600 113, India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Sudesh
authors.affiliation: Schizophrenia Research Foundation, Chennai, 600 101, India.
authors.forename: Thirunavukkarasu
authors.initials: T
authors.lastname: Priyadarshini
authors.affiliation: Schizophrenia Research Foundation, Chennai, 600 101, India.
authors.forename: Rajendran
authors.initials: R
authors.lastname: Preeti
authors.affiliation: Schizophrenia Research Foundation, Chennai, 600 101, India.
authors.forename: Sujit
authors.initials: S
authors.lastname: John
authors.affiliation: Schizophrenia Research Foundation, Chennai, 600 101, India.
authors.forename: Rangaswamy
authors.initials: R
authors.lastname: Thara
authors.affiliation: Queensland Brain Institute, The University of Queensland, Brisbane, Australia; Queensland Centre for Mental Health Research, Brisbane, Australia.
authors.forename: Bryan
authors.initials: B
authors.lastname: Mowry
authors.affiliation: Department of Genetics, University of Madras, Dr. ALM PG Institute of Basic Medical Sciences, Taramani Campus, Chennai, 600 113, India. Electronic address: akmunirajan@gmail.com.
authors.forename: Arasamabattu Kannan
authors.initials: AK
authors.lastname: Munirajan
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D051579:Neurogranin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000150:complications / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: C496649:NRGN protein, human; D051579:Neurogranin
keywords: Cases control study; GWAS replication; NRGN genotype; Schizophrenia; rs12807809