title: Validity assessment of the PROMIS fatigue domain among people living with HIV.
abstract: OBJECTIVE
  To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS®Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care.
  
  
  METHODS
  Cross-sectional and longitudinal fatigue data were collected from September 2012 through April 2013 across clinics participating in the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS). We analyzed data regarding psychometric characteristics including simulated computerized adaptive testing and differential item functioning, and regarding associations with clinical characteristics.
  
  
  RESULTS
  We analyzed data from 1597 PLWH. Fatigue was common in this cohort. Scores from the PROMIS®Fatigue Short Form and from the item bank had acceptable psychometric characteristics and strong evidence for validity, but neither performed better than shorter instruments already integrated in CNICS.
  
  
  CONCLUSIONS
  The PROMIS®Fatigue Item Bank is a valid approach to measuring fatigue in clinical care settings among PLWH, but in our analyses did not perform better than instruments associated with less respondent burden.
authors.affiliation: grid.34477.33Department of Medicine, Harborview Medical Center, University of Washington, 325 9th Ave, Box 359931, Seattle, WA USA ; grid.34477.33Harborview Medical Center, University of Washington, 325 9th Ave, Box MS 35978, Seattle, WA 98104 USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Gibbons
authors.affiliation: grid.34477.33Department of Medicine, Harborview Medical Center, University of Washington, 325 9th Ave, Box 359931, Seattle, WA USA.
authors.forename: R
authors.initials: R
authors.lastname: Fredericksen
authors.affiliation: grid.265892.2Department of Social Work, University of Alabama at Birmingham, 900 13th Street S, Suite 203, Birmingham, AL 35294 USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Batey
authors.affiliation: grid.245849.6Fenway Institute, 1340 Boylston Street, Boston, MA 02215 USA.
authors.forename: L
authors.initials: L
authors.lastname: Dant
authors.affiliation: grid.34477.33Department of Health Services, University of Washington, 1208 NE 43rd Street, Seattle, WA 98195 USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Edwards
authors.affiliation: grid.245849.6Fenway Institute, 1340 Boylston Street, Boston, MA 02215 USA ; grid.38142.3cDepartment of Medicine, Harvard Medical School, Boston, MA USA.
authors.forename: K H
authors.initials: KH
authors.lastname: Mayer
authors.affiliation: grid.266100.3Department of Medicine, University of California at San Diego, 4168 Front Street, San Diego, CA 92103 USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Mathews
authors.affiliation: grid.34477.33Center for Health Equity, Diversity and Inclusion, School of Medicine, University of Washington, 1959 Pacific Street, Seattle, WA 98195 USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Morales
authors.affiliation: grid.265892.2Department of Medicine, University of Alabama at Birmingham, 908 20th Street S, Suite 250, Birmingham, AL 35205 USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Mugavero
authors.affiliation: grid.410427.4Department of Biostatistics and Epidemiology, Augusta University, 1120 15th Street, AE-1035, Augusta, GA 30912 USA.
authors.forename: F M
authors.initials: FM
authors.lastname: Yang
authors.affiliation: grid.266100.3Department of Medicine, University of California at San Diego, 4168 Front Street, San Diego, CA 92103 USA.
authors.forename: E
authors.initials: E
authors.lastname: Paez
authors.affiliation: grid.34477.33Department of Medicine, Harborview Medical Center, University of Washington, 325 9th Ave, Box 359931, Seattle, WA USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Kitahata
authors.affiliation: grid.34477.33Department of Health Services, University of Washington, 1208 NE 43rd Street, Seattle, WA 98195 USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Patrick
authors.affiliation: grid.34477.33Department of Medicine, Harborview Medical Center, University of Washington, 325 9th Ave, Box 359931, Seattle, WA USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Crane
authors.affiliation: grid.34477.33Department of Medicine, Harborview Medical Center, University of Washington, 325 9th Ave, Box 359931, Seattle, WA USA.
authors.forename: P K
authors.initials: PK
authors.lastname: Crane
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005221:Fatigue / Q000175:diagnosis*; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000523:psychology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011594:Psychometrics / Q000379:methods; D055815:Young Adult
keywords: Fatigue; HIV; Measurement; PROMIS; Patient burden; Psychometrics; Validity