title: Roussoella solani causing keratomycosis, with an observed both sexual and asexual morphs.
abstract: We describe an 82-year-old male farmer who had diabetes mellitus with no history of ocular trauma by soil or plants and who developed a corneal infection due to a fungus. The organism was identified as Roussoella solani based on both the morphological characteristics and phylogenetic analysis using LSU and ITS nrDNA sequences. The sexual stage of R. solani is described and illustrated for the first time. The patient was treated successfully with a combination of topical and systemic voriconazole and micafungin. This case is the first report of keratomycosis caused by R. solani.
authors.affiliation: Department of Ophthalmology, Gifu University, Graduate School of Medicine, Gifu, Japan. Electronic address: mochi-gif@umin.ac.jp.
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Mochizuki
authors.affiliation: Department of Ophthalmology, Gifu University, Graduate School of Medicine, Gifu, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishida
authors.affiliation: Department of Ophthalmology, Gifu University, Graduate School of Medicine, Gifu, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Murata
authors.affiliation: Department of Ophthalmology, Gifu University, Graduate School of Medicine, Gifu, Japan; Department of Ophthalmology, Toho University, Ohashi Medical Center, Tokyo, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ishida
authors.affiliation: Department of Medical Technology, Osaka University Hospital, Osaka, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Sunada
authors.affiliation: Department of Medical Technology, Osaka University Hospital, Osaka, Japan.
authors.forename: Seishi
authors.initials: S
authors.lastname: Asari
authors.affiliation: Department of Microbiology, Tokyo Medical University, Graduate School of Medicine, Tokyo, Japan.
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ohkusu
authors.affiliation: Faculty of Agriculture and Life Science, Hirosaki University, Aomori, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000145:classification / Q000302:isolation & purification / Q000502:physiology; D054714:Echinocandins / Q000627:therapeutic use; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000382:microbiology*; D000067565:Farmers; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology*; D055666:Lipopeptides / Q000627:therapeutic use; D008297:Male; D000077551:Micafungin; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D065819:Voriconazole; D000077551:Micafungin
keywords: Keratomycosis; Micafungin; Phylogeny; Roussoella solani; Taxonomy