title: Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody.
abstract: As observed during the 2013-2016 Ebola virus disease epidemic, containment of filovirus outbreaks is challenging and made more difficult by the lack of approved vaccine or therapeutic options. Marburg and Ravn viruses are highly virulent and cause severe and frequently lethal disease in humans. Monoclonal antibodies (mAbs) are a platform technology in wide use for autoimmune and oncology indications. Previously, we described human mAbs that can protect mice from lethal challenge with Marburg virus. We demonstrate that one of these mAbs, MR191-N, can confer a survival benefit of up to 100% to Marburg or Ravn virus-infected rhesus macaques when treatment is initiated up to 5 days post-inoculation. These findings extend the small but growing body of evidence that mAbs can impart therapeutic benefit during advanced stages of disease with highly virulent viruses and could be useful in epidemic settings.
authors.affiliation: Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.|Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Chad E
authors.identifier: 0000-0001-7596-1808
authors.initials: CE
authors.lastname: Mire
authors.affiliation: Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.|Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Joan B
authors.identifier: 0000-0003-0858-1877
authors.initials: JB
authors.lastname: Geisbert
authors.affiliation: Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.|Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Viktoriya
authors.initials: V
authors.lastname: Borisevich
authors.affiliation: Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.|Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Karla A
authors.initials: KA
authors.lastname: Fenton
authors.affiliation: Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.|Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Krystle N
authors.initials: KN
authors.lastname: Agans
authors.affiliation: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
authors.forename: Andrew I
authors.identifier: 0000-0002-8722-479X
authors.initials: AI
authors.lastname: Flyak
authors.affiliation: Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA.|Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Deer
authors.affiliation: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
authors.forename: Herta
authors.identifier: 0000-0003-4823-1505
authors.initials: H
authors.lastname: Steinkellner
authors.affiliation: Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
authors.forename: Ognian
authors.initials: O
authors.lastname: Bohorov
authors.affiliation: Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
authors.forename: Natasha
authors.initials: N
authors.lastname: Bohorova
authors.affiliation: Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Goodman
authors.affiliation: Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Hiatt
authors.affiliation: Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
authors.forename: Do H
authors.identifier: 0000-0002-2725-4153
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Pauly
authors.affiliation: Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
authors.forename: Jesus
authors.initials: J
authors.lastname: Velasco
authors.affiliation: Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Whaley
authors.affiliation: Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.|Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.|Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
authors.forename: James E
authors.identifier: 0000-0002-0049-1079
authors.initials: JE
authors.lastname: Crowe
authors.affiliation: Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA. twgeisbe@utmb.edu larry.zeitlin@mappbio.com.
authors.forename: Larry
authors.identifier: 0000-0002-6857-1024
authors.initials: L
authors.lastname: Zeitlin
authors.affiliation: Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555, USA. twgeisbe@utmb.edu larry.zeitlin@mappbio.com.|Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
authors.forename: Thomas W
authors.identifier: 0000-0003-0858-1877
authors.initials: TW
authors.lastname: Geisbert
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D056738:Cross Protection; D016563:Filoviridae / Q000502:physiology*; D018702:Filoviridae Infections / Q000188:drug therapy* / Q000821:virology; D006168:Guinea Pigs; D006801:Humans; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008379:Marburg Virus Disease / Q000188:drug therapy* / Q000821:virology; D029024:Marburgvirus / Q000502:physiology*; D010865:Pilot Projects
chemical_list: D000911:Antibodies, Monoclonal