title: [Comprehensive therapeutic strategy for localized esophageal cancer].
abstract: Esophageal cancers represent a highly heterogeneous entity mixing two different tumour types : AdenoCarcinoma (ADC) and Squamous Cell Carcinoma (SSC). Developing in the same organ, they are very often considered as a unique pathology and, consequently, the same therapeutic strategy is indiscriminately applied. Esophageal cancer treatments are particularly complex and require a multidisciplinary approach. Despite impressive advances in the tumour statidifaction, surgery, radiotherapy and chemotherapy, the overall prognosis remains grim even at an early stage of the disease. In order to improve the treatment of esophageal cancers and the patientâ€™s survival, we need to consider that ADC and SCC represent two different pathologies requiring specific therapeutic strategies. This review in two parts will present recent data from clinical trials under the scope of tumour histology to set up dedicated therapeutic strategies. In this first part, we explain the restricted role of surgical resection, the prognostic factors and the results of exclusive combined chemotherapy and radiation in localized esophageal cancer.
authors.affiliation: Service de Gastroentérologie, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: D
authors.initials: D
authors.lastname: Van Daele
authors.affiliation: Service de Chirurgie digestive, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: P
authors.initials: P
authors.lastname: Honoré
authors.affiliation: Service d'Oncologie, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: J
authors.initials: J
authors.lastname: Collignon
authors.affiliation: Service de Gastroentérologie, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: M
authors.initials: M
authors.lastname: Polus
authors.affiliation: Service de Gastroentérologie, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: C
authors.initials: C
authors.lastname: Loly
authors.affiliation: Département de Cytologie et d'Anatomopathologie, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: E
authors.initials: E
authors.lastname: Mutijima
authors.affiliation: Service de Chirurgie digestive, CHR de la Citadelle, Liège, Belgique.
authors.forename: A
authors.initials: A
authors.lastname: De Roover
authors.affiliation: Département de Radiothérapie, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: P A
authors.initials: PA
authors.lastname: Coucke
authors.affiliation: Service de Gastroentérologie, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: E
authors.initials: E
authors.lastname: Louis
authors.affiliation: Département de Radiothérapie, CHU de Liège, Site Sart Tilman, Liège, Belgique.
authors.forename: P
authors.initials: P
authors.lastname: Martinive
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000628:therapy*; D006801:Humans
keywords:  Adenocarcinoma ;  Combined chemo;  Esophageal cancer ;  Squamous Cell Carcinoma ;  Surgical resection ;  Treatment ; radiation