title: The Contribution of Matrix Metalloproteinase-1 Genotypes to Hepatocellular Carcinoma Susceptibility in Taiwan.
abstract: Metalloproteinases (MMPs) are a family of proteases which have been shown to be overexpressed in various types of cancers. However, the contribution of MMP1 genotype to hepatocellular carcinoma (HCC) has not been well studied. This study aimed to evaluate the contribution of MMP1 promoter 1607 genotype to the risk of HCC in Taiwan, where HCC incidence is relatively high in the world.
  
  
  
  In this case-control study, MMP1 genotype and its interaction with consumption of cigarettes and alcohol in determining HCC risk was investigated among 298 HCC patients and 889 age- and gender-matched healthy controls.
  
  
  
  The percentages of ever smokers and ever alcohol drinkers were much higher in the case group than in the control group. The percentages of 2G/2G, 1G/2G and 1G/1G for MMP1 promoter 1607 genotype were 37.2%, 38.3% and 24.5% in the HCC group and 34.8%, 44.0% and 21.2% in the control group, respectively (p for trend=0.2048). The allelic frequency distribution analysis showed the variant 1G allele of MMP1 promoter 1607 conferred similar HCC susceptibility as the wild-type 2G allele (odds ratio (OR)=1.01, 95% confidence interval (CI)=0.84-1.22, p=0.8735). As for the gene-lifestyle interaction, there was an obvious protective effect of MMP1 promoter 1607 1G allele on the risk of HCC among non-smokers, but not non-smokers, even alcohol drinkers or non-drinkers.
  
  
  
  The 1G allele of MMP1 promoter 1607 may have a protective effect on HCC risk for non-smokers in Taiwan and further validations are needed in other population groups.
authors.affiliation: Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Yi-Liang
authors.initials: YL
authors.lastname: Lai
authors.affiliation: Department of Physiology, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Chi-Li
authors.initials: CL
authors.lastname: Gong
authors.affiliation: Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.|Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Chun-Kai
authors.initials: CK
authors.lastname: Fu
authors.affiliation: Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.|Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
authors.forename: Te-Cheng
authors.initials: TC
authors.lastname: Yueh
authors.affiliation: Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.affiliation: Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Wen-Shin
authors.initials: WS
authors.lastname: Chang
authors.affiliation: Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Chieh-Lun
authors.initials: CL
authors.lastname: Hsiao
authors.affiliation: Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Shiou-Ting
authors.initials: ST
authors.lastname: Yen
authors.affiliation: Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Hsin-Ting
authors.initials: HT
authors.lastname: Li
authors.affiliation: Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
authors.forename: Long-Bin
authors.initials: LB
authors.lastname: Jeng
authors.affiliation: Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com.|Natiosnal Defense Medical Center, Taipei, Taiwan, R.O.C.
authors.forename: Shou-Cheng
authors.initials: SC
authors.lastname: Wang
authors.affiliation: Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com.|Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.|Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
authors.forename: DA-Tian
authors.initials: DT
authors.lastname: Bau
mesh_terms: D000428:Alcohol Drinking; D000483:Alleles; D044466:Asian People / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000208:ethnology / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking; D013624:Taiwan
chemical_list: D020781:Matrix Metalloproteinase 1
keywords: Genotyping; MMP1; hepatocellular carcinoma; polymorphism