title: Neck Rhabdoid Tumors: Clinical Features and Consideration of Autologous Stem Cell Transplant.
abstract: Extrarenal malignant rhabdoid tumors (MRT) have a poor prognosis despite aggressive therapy. Adding high-dose chemotherapy with autologous stem cell rescue (HDC-ASCR) as consolidative therapy for MRT is controversial. We describe 2 patients, age 13 years and 19 months, with unresectable neck MRT. After chemotherapy and radiotherapy, both underwent HDC-ASCR and remain in remission over 4 years later. We reviewed all published cases of neck MRT, and found poorer outcomes and more variable age of presentation and time to progression than MRT at other sites. Neck MRT may represent a higher-risk subset of MRT, and addition of HDC-ASCR merits consideration.
authors.affiliation: Department of Pediatric Hematology-Oncology, Children's Hospital of San Antonio-Baylor College of Medicine, San Antonio, TX.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Wolfe
authors.affiliation: Departments of Pediatric Hematology, Oncology & Bone Marrow Transplant.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Capitini
authors.affiliation: Pathology.
authors.forename: Shahriar M
authors.initials: SM
authors.lastname: Salamat
authors.affiliation: Departments of Pediatric Hematology, Oncology & Bone Marrow Transplant.
authors.forename: Kenneth
authors.initials: K
authors.lastname: DeSantes
authors.affiliation: Human Oncology.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Bradley
authors.affiliation: Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
authors.forename: Tabassum
authors.initials: T
authors.lastname: Kennedy
authors.affiliation: Department of Pathology and Immunology, Washington University Medical School, St Louis Children's Hospital, St Louis, MO.
authors.forename: Louis P
authors.initials: LP
authors.lastname: Dehner
authors.affiliation: Departments of Pediatric Hematology, Oncology & Bone Marrow Transplant.
authors.forename: Neha J
authors.initials: NJ
authors.lastname: Patel
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D060830:Consolidation Chemotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007223:Infant; D008297:Male; D012074:Remission Induction; D018335:Rhabdoid Tumor / Q000628:therapy*; D014182:Transplantation, Autologous