title: MMP-2 and 9 in Chronic Kidney Disease.
abstract: Gelatinases are members of the matrix metalloproteinase (MMPs) family; they play an important role in the degradation of the extracellular matrix (ECM). This effect is also crucial in the development and progression of chronic kidney disease (CKD). Its expression, as well as its activity regulation are closely related to the cell signaling pathways, hypoxia and cell membrane structural change. Gelatinases also can affect the development and progression of CKD through the various interactions with tumor necrosis factors (TNFs), monocyte chemoattractant proteins (MCPs), growth factors (GFs), oxidative stress (OS), and so on. Currently, their non-proteolytic function is a hot topic of research, which may also be associated with the progression of CKD. Therefore, with the in-depth understanding about the function of gelatinases, we can have a more specific and accurate understanding of their role in the human body.
authors.affiliation: Department of Pathology and Pathophysiology, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China. 230159257@seu.edu.cn.
authors.forename: Zhengyuan
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Department of Pathology and Pathophysiology, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China. 223136077@seu.edu.cn.
authors.forename: Manoj Hang
authors.initials: MH
authors.lastname: Limbu
authors.affiliation: Department of Pathology and Pathophysiology, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China. 76wangzhi76@163.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Pathology and Pathophysiology, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China. 230149691@seu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathology and Pathophysiology, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China. 230169250@seu.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pathology and Pathophysiology, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China. zhxynanjing@163.com.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pathology and Pathophysiology, Medical School, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China. 101006254@seu.edu.cn.
authors.forename: Pingsheng
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Nephrology, Zhongda Hospital, Southeast University, Dingjiaqiao 87, Gulou District, Nanjing 210009, China. liubc64@163.com.
authors.forename: Bicheng
authors.initials: B
authors.lastname: Liu
mesh_terms: D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D018945:Monocyte Chemoattractant Proteins / Q000378:metabolism; D011485:Protein Binding; D051436:Renal Insufficiency, Chronic / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D048069:Tumor Necrosis Factors / Q000378:metabolism
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D018945:Monocyte Chemoattractant Proteins; D048069:Tumor Necrosis Factors; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
keywords: chronic kidney disease; gelatinases; matrix metalloproteinase; non-proteolytic function