title: Neuro-oncological ventral antigen 1 (NOVA1): Implications in neurological diseases and cancers.
abstract: Neuro-oncological ventral antigen 1 (NOVA1) is a RNA-binding protein that interacts with RNA containing repeats of the YCAY sequence. This protein is a brain-specific splicing factor regulating neuronal alternative splicing. It has been increasingly recognized as an important contributor to neurological disorders and carcinogenesis. In this review, we summarize the biological functions and pathological roles of NOVA1. The clinical implications of NOVA1 will also be discussed.
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xin
authors.affiliation: Department of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
authors.forename: Zheng
authors.identifier: http://orcid.org/0000-0001-6024-0194
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China.
authors.forename: Heyi
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Jeffery
authors.initials: J
authors.lastname: Ho
authors.affiliation: Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Matthew T V
authors.initials: MTV
authors.lastname: Chan
authors.affiliation: Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong.|State Key Laboratory of Digestive Disease and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong.
authors.forename: William K K
authors.initials: WKK
authors.lastname: Wu
mesh_terms: D063646:Carcinogenesis; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism / Q000473:pathology*; D000090682:Neuro-Oncological Ventral Antigen; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D009419:Nerve Tissue Proteins; D000090682:Neuro-Oncological Ventral Antigen; D016601:RNA-Binding Proteins; D012313:RNA