title: Programmable Nano-Bio Interfaces for Functional Biointegrated Devices.
abstract: A large amount of evidence has demonstrated the revolutionary role of nanosystems in the screening and shielding of biological systems. The explosive development of interfacing bioentities with programmable nanomaterials has conveyed the intriguing concept of nano-bio interfaces. Here, recent advances in functional biointegrated devices through the precise programming of nano-bio interactions are outlined, especially with regard to the rational assembly of constituent nanomaterials on multiple dimension scales (e.g., nanoparticles, nanowires, layered nanomaterials, and 3D-architectured nanomaterials), in order to leverage their respective intrinsic merits for different functions. Emerging nanotechnological strategies at nano-bio interfaces are also highlighted, such as multimodal diagnosis or "theragnostics", synergistic and sequential therapeutics delivery, and stretchable and flexible nanoelectronic devices, and their implementation into a broad range of biointegrated devices (e.g., implantable, minimally invasive, and wearable devices). When utilized as functional modules of biointegrated devices, these programmable nano-bio interfaces will open up a new chapter for precision nanomedicine.
authors.affiliation: Innovative Center for Flexible Devices, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
authors.forename: Pingqiang
authors.initials: P
authors.lastname: Cai
authors.affiliation: Innovative Center for Flexible Devices, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
authors.forename: Wan Ru
authors.initials: WR
authors.lastname: Leow
authors.affiliation: Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, P. R. China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, P. R. China.
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Wu
authors.affiliation: Innovative Center for Flexible Devices, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Chen
mesh_terms: D050997:Nanomedicine; D053758:Nanoparticles; D049329:Nanostructures; D036103:Nanotechnology
keywords: biointegrated devices; nano-bio interfaces; nanomedicine; programmable nanomaterials