title: Impact of the neural correlates of stress and cue reactivity on stress related binge eating in the natural environment.
abstract: Women with symptoms of bulimia nervosa (BN) exhibit decreased response to visual food cues in several limbic and frontal regions compared to controls. Stress causes decreased blood oxygenation level dependent (BOLD) response in these regions in non-clinical samples; there is a lack of data on this topic in BN. This study examined the impact of individual differences in neural reactivity to palatable food cues following acute stress on stress-binge trajectories in everyday life. 16 women with BN symptoms viewed palatable food cues prior to and immediately following an acute stress induction in the scanner. Participants then responded to a series of prompts assessing daily ratings of stress and binge episodes for a period of two weeks. Decreased BOLD signal was observed in response to food cues pre to post stress in the anterior cingulate cortex (ACC), amygdala, and ventromedial prefrontal cortex (vmPFC). Ecological momentary assessment data collection demonstrated that stress increased prior to binge episodes in the natural environment, and decreased following. Changes in activation in the ACC, precuneus, and dorsolateral prefrontal cortex (dlPFC) significantly moderated the relationship of stress to binge eating in daily life, such that women who exhibited decreased response reported significantly increasing stress prior to binges, while women who did not exhibit decreases reported no significant change in stress prior to binges. Individual differences in neural response to food cues under stress appear to underlie distinct antecedants to binge eating.
authors.affiliation: Department of Psychology, George Mason University, Fairfax, VA, USA. Electronic address: snowaczy@gmu.edu.
authors.forename: Sarah
authors.initials: S
authors.lastname: Fischer
authors.affiliation: Department of Psychology, George Mason University, Fairfax, VA, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Breithaupt
authors.affiliation: Department of Psychology, George Mason University, Fairfax, VA, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Wonderlich
authors.affiliation: UK2 Department of Psychiatry, University of Cambridge, Herchel Smith Building, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Margaret L
authors.initials: ML
authors.lastname: Westwater
authors.affiliation: Neuropsychiatric Research Institute, Fargo, ND, USA; University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA.
authors.forename: Ross D
authors.initials: RD
authors.lastname: Crosby
authors.affiliation: Neuropsychiatric Research Institute, Fargo, ND, USA; University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA.
authors.forename: Scott G
authors.initials: SG
authors.lastname: Engel
authors.affiliation: Department of Psychology, George Mason University, Fairfax, VA, USA.
authors.forename: James
authors.initials: J
authors.lastname: Thompson
authors.affiliation: Neuropsychiatric Research Institute, Fargo, ND, USA; University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Lavender
authors.affiliation: Neuropsychiatric Research Institute, Fargo, ND, USA; University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Wonderlich
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D002032:Bulimia / Q000150:complications*; D003463:Cues; D004777:Environment; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D011569:Psychiatric Status Rating Scales; D013315:Stress, Psychological / Q000150:complications*; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Binge; Bulimia; EMA; Neuroimaging; Stress