title: Low serum levels of uric acid and albumin in patients with Guillain-Barre syndrome.
abstract: Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain-Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate with oxidative stress in some degree. We aimed to evaluate the relationship between GBS and serum levels of UA and albumin in the present study.The serum levels of UA and albumin were determined in 203 individuals including 88 patients with GBS and 153 healthy controls (HC).We found that serum levels of UA and albumin in patients with GBS were significantly lower than those in HC group. Besides, similar phenomenon was observed when the male and female subgroups were estimated, respectively. Additionally, we found that there is no statistic difference among subgroups of GBS regarding UA and albumin. The univariate analysis revealed that both the high UA and high albumin were protective factors for patients with GBS (odds ratio [OR] 0.140; 95% confidence interval [CI]: 0.074-0.264; P < .001 and OR 0.016; 95% CI: 0.006-0.038; P < .001, respectively). It was further confirmed by the multivariable logistic regression analysis after adjusting for other potential confounding factors (OR 0.168; 95% CI: 0.055-0.514; P = .002 and OR 0.027; 95% CI: 0.011-0.071; P < .001, respectively).In conclusion, we found that patients with GBS had significantly low serum UA and albumin levels. Moreover, we demonstrated that both the high UA and high albumin were protective factors for patients with GBS.
authors.affiliation: Department of Neurology, Wenzhou Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou Department of Endocrinology, Wenzhou Department of Orthopedic Surgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou Department of Orthopedic Surgery, The Second Affiliated Hospital of Wenzhou Medical University Department of Infection and Liver Diseases, Liver Research Center Department of Cardiovascular Medicine, The Heart Center Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Brain Research Centre and Department of Biology, Southern University of Science and Technology, Shenzhen, China.
authors.forename: Zhongqian
authors.initials: Z
authors.lastname: Su
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Chen
authors.forename: Yian
authors.initials: Y
authors.lastname: Xiang
authors.forename: Bingjie
authors.initials: B
authors.lastname: Wang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Huang
authors.forename: Dehao
authors.initials: D
authors.lastname: Yang
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Weng
authors.forename: XianFeng
authors.initials: X
authors.lastname: Lin
authors.forename: Guoqian
authors.initials: G
authors.lastname: Chen
authors.forename: Wenyue
authors.initials: W
authors.lastname: Liu
authors.forename: Chenchen
authors.initials: C
authors.lastname: Zhao
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Wang
authors.forename: Shanshan
authors.initials: S
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Weiwei
authors.initials: W
authors.lastname: Quan
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Tong
authors.forename: Shengjie
authors.initials: S
authors.lastname: Wu
authors.forename: Shihao
authors.initials: S
authors.lastname: Huang
authors.forename: Peina
authors.initials: P
authors.lastname: Mei
authors.forename: Zhengzheng
authors.initials: Z
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Shengtao
authors.initials: S
authors.lastname: Hou
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020275:Guillain-Barre Syndrome / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D065840:Protective Factors; D012709:Serum Albumin / Q000032:analysis*; D014527:Uric Acid / Q000097:blood*
chemical_list: D012709:Serum Albumin; D014527:Uric Acid