title: [Comprehensive pharmacologic management of overactive bladder].
abstract: Overactive bladder (OAB) is a common and bothersome condition manifested by urgency, frequent urination, significantly impairing patients quality of life. The article presents an overview of the evidence on pharmacotherapy of neurogenic and idiopathic OAB. Selective M3 receptor blockers have been shown to be the medications of choice in treating these patients. Many studies have shown that solifenacin 10 mg is a starting dose for patients with OAB. Mirabegron (Betmiga) is the only 3-adrenergic receptor agonist approved for primary treatment of OAB patients refractory to anticholinergics or have their side effects. It seems promising to use this drug, both as monotherapy and concurrently with anticholinergic agents to improve treatment results in patients with idiopathic and neurogenic OAB.
authors.affiliation: Department of Urology and Andrology, Medical Faculty of N.I. Pirogov RNRMU of Minzdrav of Russia, Moscow.|Department of Urology, Russian Gerontology Research and Clinical Center, Moscow, Russia.
authors.forename: G G
authors.initials: GG
authors.lastname: Krivoborodov
authors.affiliation: Universita degli studi di Firenze, Florence, Italy.
authors.forename: E I
authors.initials: EI
authors.lastname: Tur
mesh_terms: D000083:Acetanilides / Q000627:therapeutic use; D058667:Adrenergic beta-3 Receptor Agonists / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D000069464:Solifenacin Succinate / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D000077409:Tamsulosin; D013844:Thiazoles / Q000627:therapeutic use; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy / Q000209:etiology; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000083:Acetanilides; D058667:Adrenergic beta-3 Receptor Agonists; D004338:Drug Combinations; D018727:Muscarinic Antagonists; D013449:Sulfonamides; D013844:Thiazoles; D000077409:Tamsulosin; D000069464:Solifenacin Succinate; C520025:mirabegron
keywords: 3-adrenergic receptor agonists; idiopathic overactive bladder; m-cholinergic receptor blockers; neurogenic overactive bladder; urge incontinence; urinary frequency