title: Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa.
abstract: The mechanisms of dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) remain unclear, although it is known that the nucleus accumbens (NAc) plays a role in its development. Based on the hypothesis that DDS and levodopa-induced dyskinesia (LID) share a pathophysiological basis, we investigated dendritic spine morphology of medium spiny neurons (MSNs) in the NAc of a rat model of LID, because spine enlargement in MSNs of the caudate/putamen has been proposed to be a morphological hallmark of LID. Spines of NAc MSNs also became enlarged in the LID model. This result suggests that excitatory supersensitivity of MSNs in the NAc is involved in the development of DDS, similar to what occurs in the caudate/putamen in LID.
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori 030-8553, Japan; Department of Pathology and Molecular Medicine, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Electronic address: operationalbigsafe@gmail.com.
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Funamizu
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori 030-8553, Japan; Department of Neurophysiology, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Electronic address: hnishijima-tky@umin.ac.jp.
authors.forename: Haruo
authors.initials: H
authors.lastname: Nishijima
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori 030-8553, Japan; Department of Neurophysiology, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Electronic address: tatsuya_ueno@med.pref.aomori.jp.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ueno
authors.affiliation: Department of Neurophysiology, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Electronic address: shinyau@hirosaki-u.ac.jp.
authors.forename: Shinya
authors.initials: S
authors.lastname: Ueno
authors.affiliation: Department of Pathology and Molecular Medicine, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Electronic address: hirokim@hirosaki-u.ac.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Mizukami
authors.affiliation: Department of Pathology and Molecular Medicine, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Electronic address: yagihasi@hirosaki-u.ac.jp.
authors.forename: Soroku
authors.initials: S
authors.lastname: Yagihashi
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, 2-1-1 Higashi-Tsukurimichi, Aomori 030-8553, Japan; Department of Neurophysiology, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Japan. Electronic address: masahiko_tomiyama@med.pref.aomori.jp.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tomiyama
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D049229:Dendritic Spines / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D015259:Dopamine Agents / Q000627:therapeutic use*; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects / Q000293:injuries; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D009714:Nucleus Accumbens / Q000473:pathology*; D016627:Oxidopamine / Q000633:toxicity*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013565:Sympatholytics / Q000633:toxicity*; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D015259:Dopamine Agents; D013565:Sympatholytics; D007980:Levodopa; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase; D001058:Apomorphine
keywords: Dendritic spine morphology; Dopamine dysregulation syndrome; Levodopa-induced dyskinesia; Nucleus accumbens