title: The role of dosimetry audit in lung SBRT multi-centre clinical trials.
abstract: Stereotactic Body Radiotherapy (SBRT) in the lung is a challenging technique which requires high quality clinical trials to answer the un-resolved clinical questions. Quality assurance of these clinical trials not only ensures the safety of the treatment of the participating patients but also minimises the variation in treatment, thus allowing the lowest number of patient treatments to answer the trial question. This review addresses the role of dosimetry audits in the quality assurance process and considers what can be done to ensure the highest accuracy of dose calculation and delivery and it's assessment in multi-centre trials.
authors.affiliation: Royal Surrey County Hospital, Guildford, UK; National Physical Laboratory, Teddington, UK; National Radiotherapy Trials QA (RTTQA) Group, Mount Vernon Hospital, Northwood, UK. Electronic address: catharine.clark@nhs.net.
authors.forename: Catharine H
authors.initials: CH
authors.lastname: Clark
authors.affiliation: Catharina Ziekenhuis, Eindhoven, The Netherlands; European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium.
authors.forename: Coen W
authors.initials: CW
authors.lastname: Hurkmans
authors.affiliation: MD Andersen Cancer Center, Houston, TX, USA; Imaging and Radiation Oncology Core (IROC), Houston, USA.
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Kry
mesh_terms: D054869:Clinical Audit; D002986:Clinical Trials as Topic; D006801:Humans; D015337:Multicenter Studies as Topic; D011874:Radiometry / Q000592:standards*; D016634:Radiosurgery
keywords: Clinical trials; Dosimetry audit; Lung SBRT