title: Optical Biometry Derived Axial Length Measurements Following Intravitreal Anti-Vascular Endothelial Growth Factor Treatment for Macular Edema.
abstract: OBJECTIVE
  To evaluate axial length (AL) alterations in patients with macular disease over the course of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment.
  
  
  METHODS
  In this prospective, comparative study, 33 patients with macular edema underwent unilaterally intravitreal anti-VEGF therapy and were followed for two months; the contralateral eyes were considered as controls. Central retinal thickness (CRT) was measured with spectral-domain optical coherence tomography and AL with an IOL-Master optical biometer.
  
  
  RESULTS
  CRT of the treated eyes decreased by 35.33 ± 65.59 μm (range, -222.00-67 μm), while AL increased by 0.008 ± 0.062 mm (range, -0.11-0.18 mm). CRT of the control group decreased by 9.82 ± 65.40 μm (range, -203-182 μm), and AL increased by 0.011 ± 0.129 mm (range, -0.20-0.67 mm). No significant correlation was detected between CRT and AL parameters (rhos=0.026, P=0.882).
  
  
  CONCLUSIONS
  Anti-VEGF administration has no significant impact on optical biometry-derived AL measurements.
authors.affiliation: a First Division of Ophthalmology, Faculty of Medicine , National and Kapodistrian University of Athens , Athens , Greece.|b Jules Gonin Eye Hospital , University of Lausanne , Lausanne , Switzerland.
authors.forename: George D
authors.initials: GD
authors.lastname: Kymionis
authors.affiliation: c Department of Opthalmology , University Hospital of Heraklion , Heraklion , Crete , Greece.
authors.forename: Athanassios
authors.initials: A
authors.lastname: Giarmoukakis
authors.affiliation: d Vardinoyiannion Eye Institute of Crete , Faculty of Medicine, University of Crete , Heraklion , Crete , Greece.
authors.forename: Ioanna K
authors.initials: IK
authors.lastname: Apostolidi
authors.affiliation: c Department of Opthalmology , University Hospital of Heraklion , Heraklion , Crete , Greece.|d Vardinoyiannion Eye Institute of Crete , Faculty of Medicine, University of Crete , Heraklion , Crete , Greece.
authors.forename: Styliani V
authors.initials: SV
authors.lastname: Blazaki
authors.affiliation: c Department of Opthalmology , University Hospital of Heraklion , Heraklion , Crete , Greece.|d Vardinoyiannion Eye Institute of Crete , Faculty of Medicine, University of Crete , Heraklion , Crete , Greece.
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Tsoulnaras
authors.affiliation: e Department of Social Medicine, Faculty of Medicine , University of Crete , Heraklion , Crete , Greece.
authors.forename: Joanna
authors.initials: J
authors.lastname: Moschandrea
authors.affiliation: d Vardinoyiannion Eye Institute of Crete , Faculty of Medicine, University of Crete , Heraklion , Crete , Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Panagopoulou
authors.affiliation: c Department of Opthalmology , University Hospital of Heraklion , Heraklion , Crete , Greece.|d Vardinoyiannion Eye Institute of Crete , Faculty of Medicine, University of Crete , Heraklion , Crete , Greece.
authors.forename: Miltiadis K
authors.initials: MK
authors.lastname: Tsilimbaris
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D058452:Axial Length, Eye / Q000000981:diagnostic imaging*; D001699:Biometry / Q000379:methods*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D058449:Intravitreal Injections; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D011446:Prospective Studies; D000069579:Ranibizumab / Q000008:administration & dosage*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*; D014792:Visual Acuity
chemical_list: D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A; D000069579:Ranibizumab
keywords: Anti-vascular endothelial growth factor; IOL Master biometry; axial length; central retinal thickness; macular edema