title: Addressing a weakness of anticancer therapy with mitosis inhibitors: Mitotic slippage.
abstract: Mitosis inhibitors, which include antimicrotubule drugs, are chemotherapy agents that induce the arrest and apoptosis of mitotic cells. Mitotic slippage, in which mitotically arrested cells exit mitosis, limits the effectiveness of mitosis inhibitors. We have discovered that the CRL2ZYG11A/Bubiquitin ligase promotes mitotic slippage. The combination of antimicrotubule drugs and a CRL2ZYG11A/Binhibitor prevents mitotic slippage to increase antimitotic efficacy.
authors.affiliation: Department of Cellular Biology, University of Georgia , Athens, GA, USA.
authors.forename: Riju S
authors.initials: RS
authors.lastname: Balachandran
authors.affiliation: Department of Cellular Biology, University of Georgia , Athens, GA, USA.
authors.forename: Edward T
authors.initials: ET
authors.lastname: Kipreos
keywords: APC/C; ZYG11A; ZYG11B; antimicrotubule drugs; antimitotic chemotherapy; cullin-RING ubiquitin ligase; cyclin B1; mitotic slippage; tetraploid checkpoint; tetraploidy