title: Effect of Training at Lactate Threshold Intensity on Maximal Time to Exhaustion, Depression and Anxiety Behaviour of Spontaneously Hypertensive Rats after Kainate-Induced Status Epilepticus.
abstract: OBJECTIVE
  The objective of the present study was to investigate the effect of treadmill training at lactate threshold intensity on maximum time to exhaustion (MTE) and heart rate (HR) as well as behavioral changes after kainate (KA)-induced status epilepticus (SE) of spontaneously hypertensive rats (SHRs).
  
  
  METHODS
  Male SHRs were divided in four groups: two sedentary (vehicle- and KA-treated) and two exercised (vehicle- and KA-treated), respectively. The exercised rats were trained on a treadmill at a speed of 20 m.min-1 and 0° elevation for 40 min.d-1, for 4 wk. Maximal time to exhaustion and HR was measured at the beginning and at the end of the training period. Status epilepticus was evoked in half of the sedentary and trained rats by a repetitive intraperitoneal injection of KA in low subconvulsive doses. The other half of the groups received saline. Sucrose preference test (SPT) for depression-like behavior and hole board test (HBT) for impulsivity were performed a month after KA/veh injection.
  
  
  RESULTS
  The maximum time of exhaustion was elongated in the SHRs at the end of the training period in comparison with the beginning. However, no effect on HR was detected in trained rats. Kainate treatment after one month of training alleviated the SE-induced anhedonia in SPT and stereotyped behavior in HBT, respectively.
  
  
  CONCLUSIONS
  Taken together, these results demonstrate that exercise exerts a beneficial influence on physical working capacity, depression and impulsive behavior in a co-morbid model of essential hypertension and SE.
authors.affiliation: Department of Physiology, Medical University of Plovdiv, 15A Vassil Aprilov Blvd., 4002 Plovdiv.
authors.forename: Katerina N
authors.initials: KN
authors.lastname: Georgieva
authors.affiliation: Department of Physiology, Medical University of Plovdiv, 15A Vassil Aprilov Blvd., 4002 Plovdiv.
authors.forename: Margarita S
authors.initials: MS
authors.lastname: Hadjieva
authors.affiliation: Department of Pharmacology and Drug Toxicology, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv.
authors.forename: Mihaela S
authors.initials: MS
authors.lastname: Shishmanova-Doseva
authors.affiliation: Department of Clinical Laboratory, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv.
authors.forename: Dora D
authors.initials: DD
authors.lastname: Terzieva
authors.affiliation: Faculty of Medicine, Medical University of Plovdiv, Plovdiv.
authors.forename: Nikola G
authors.initials: NG
authors.lastname: Georgiev
authors.affiliation: Faculty of Medicine, Medical University of Plovdiv, Plovdiv.
authors.forename: Georgi G
authors.initials: GG
authors.lastname: Andreev
authors.affiliation: Institute of Neurobiology, BAS, Sofia.
authors.forename: Jana D
authors.initials: JD
authors.lastname: Tchekalarova
mesh_terms: D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000502:physiology*; D015897:Comorbidity; D003863:Depression / Q000523:psychology*; D004195:Disease Models, Animal; D000075222:Essential Hypertension; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D005221:Fatigue; D006339:Heart Rate; D006973:Hypertension; D007175:Impulsive Behavior / Q000502:physiology; D007608:Kainic Acid / Q000633:toxicity; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology* / Q000523:psychology; D051381:Rats; D011918:Rats, Inbred SHR; D013226:Status Epilepticus / Q000139:chemically induced; D013997:Time Factors
chemical_list: D018690:Excitatory Amino Acid Agonists; D019344:Lactic Acid; D007608:Kainic Acid
keywords: SHRs; anxiety; status epilepticus; treadmill training