title: Non-coding RNAs: new biomarkers and therapeutic targets for esophageal cancer.
abstract: Esophageal cancer is one of the most common gastrointestinal malignant diseases and there is still no effective treatment. The incidence of esophageal cancer in the world is relatively high and on the increase year by year. Thus, the elaboration on the carcinogenesis of esophageal cancer and the identification of new biomarkers and therapeutic targets is quite beneficial to optimizing the current therapeutic regimen for treating such deadly disease. More and more evidence has shown that non-coding RNAs play an important role in the development and progression of multiple human cancers, including esophageal cancer. microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two functional kinds of non-coding RNAs that have been well investigated. They exert tumor suppressive or promoting effect by specifically regulating the expression of certain downstream target genes, which is tumor specific. It is also proved that miRNAs and lncRNAs level in tissue and plasma from esophageal cancer patients are closely correlated with the survival and disease progression, which could be used as a prognostic factor and therapeutic target for esophageal cancer.
authors.affiliation: Department of Thoracic Surgery, PLA General Hospital, Beijing, China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Thoracic Surgery, PLA General Hospital, Beijing, China.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Thoracic Surgery, PLA General Hospital, Beijing, China.
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Medical Science Weekly, Beijing, China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality / Q000628:therapy; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D058990:Molecular Targeted Therapy; D011379:Prognosis; D062085:RNA, Long Noncoding; D011836:Radiation Tolerance / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D062085:RNA, Long Noncoding
keywords: biomarker; esophageal cancer; lncRNAs; miRNAs; therapeutic target