title: Antibacterial and bioactive coatings on titanium implant surfaces.
abstract: Various surface modifications have been tried for enhancing osseointegration of the dental implants like mechanical and/or chemical treatments and deposition of calcium phosphate coatings. The objective of this research was to develop calcium-phosphate based thin coatings with antibacterial and bioactive properties for potential application in dental implants. Titanium (Ti) discs were immersed in different calcifying solutions: CaP (positive control), F-CaP, Zn-CaP, and FZn-CaP and incubated for 24 h. Negative control was uncoated Ti discs. Coated surfaces were characterized using X-ray diffraction, scanning electron microscopy and energy dispersive spectroscopy. Antibacterial properties were tested using Porphyromonas gingivalis because of its strong association with periodontal and peri-implant infections. Bacterial adhesion and colonization were studied at different timepoints. The coated surfaces had compositional characteristics similar to that of bone mineral and they inhibited the growth, colonization and adherence of P. gingivalis, resulted in reduced thickness of biofilms and bacterial inhibition in the culture medium as compared to the positive and negative controls (p < 0.05). There was no significant difference between the experimental groups (p > 0.05). It has been previously demonstrated that these coatings have excellent in vitro bioactivity (formed carbonate hydroxyapatite when immersed in a simulated body fluid). Such coatings can enhance osseointegration and prevent infection in implants, thereby improving the success rates of implants. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2218-2227, 2017.
authors.affiliation: Department of Biomaterials and Biomimetics, New York University College of Dentistry, 433 First Avenue, New York, New York, 10010.
authors.forename: Anupama
authors.initials: A
authors.lastname: Kulkarni Aranya
authors.affiliation: Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, 345 E 24th Street, New York, New York, 10010.
authors.forename: Smruti
authors.initials: S
authors.lastname: Pushalkar
authors.affiliation: Department of Biomaterials and Biomimetics, New York University College of Dentistry, 433 First Avenue, New York, New York, 10010.
authors.forename: Minglei
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Biomaterials and Biomimetics, New York University College of Dentistry, 433 First Avenue, New York, New York, 10010.
authors.forename: Racquel Z
authors.initials: RZ
authors.lastname: LeGeros
authors.affiliation: Department of Biomaterials and Biomimetics, New York University College of Dentistry, 433 First Avenue, New York, New York, 10010.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, 345 E 24th Street, New York, New York, 10010.
authors.forename: Deepak
authors.initials: D
authors.lastname: Saxena
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D016866:Bacteroidaceae Infections / Q000517:prevention & control; D018441:Biofilms / Q000187:drug effects; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D015921:Dental Implants / Q000382:microbiology*; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D016966:Porphyromonas gingivalis / Q000187:drug effects / Q000502:physiology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium
keywords: Porphyromonas gingivalis; antibacterial; bioactivity; dental implant; implant coatings