title: Nevi, Ambient Ultraviolet Radiation, and Thyroid Cancer Risk: A French Prospective Study.
abstract: Incidence rates have increased considerably worldwide for both differentiated thyroid cancer and cutaneous melanoma, and two-way associations between these neoplasms have been described. Whether melanoma risk factors are associated with thyroid cancer risk remains unknown.
  
  
  
  Using Cox regression modeling, we prospectively analyzed the relationship between self-reported pigmentary traits, baseline residential ultraviolet (UV) exposure, and thyroid cancer risk in 86,960 women from the E3N cohort, followed-up over 1990-2008 through biennial questionnaires. We assessed associations of pigmentary traits and UV exposure with personal history of benign thyroid diseases using logistic regression modeling. All statistical tests were two sided.
  
  
  
  In models adjusted for age and thyroid cancer risk factors, number of nevi was positively associated with thyroid cancer risk ("very many" vs. "none": hazards ratio [HR] = 1.7, 95% confidence interval [CI] = 1.0, 2.8; Ptrend = 0.01), independently of residential UV exposure or iodine intake. Risk was inversely associated with latitude and positively associated with mean daily UV level at baseline (HRs for the fourth vs. first quartile of latitude and spring/summer UVB level = 0.7, 95% CI = 0.5, 0.9; Ptrend = 0.03, and HR = 1.9, 95% CI = 1.4, 2.7; Ptrend = 0.02, respectively); associations were restricted to women with dietary iodine below the median intake. Number of nevi and UV level were also associated with personal histories of dysthyroidism and of goiter/nodules, although more weakly so.
  
  
  
  Our results suggest that number of nevi and residential UV exposure are associated with the risks of thyroid cancer and benign conditions. They point to novel pathways in thyroid cancer or melanoma etiologies and warrant replication.
authors.affiliation: From the aUniversité Paris-Saclay, University of Paris-Sud, UVSQ, Inserm, CESP, Generations and Health Team, Villejuif, France; bGustave Roussy, Villejuif, France; cHôpital Bretonneau, CHRU de Tours, Gynécologie-Obstétrique, Tours, France; and dMINES ParisTech, PSL-Research University, O.I.E. - Centre Observation, Impacts, Energy, Sophia Antipolis, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mesrine
authors.forename: Marina
authors.initials: M
authors.lastname: Kvaskoff
authors.forename: Thierno
authors.initials: T
authors.lastname: Bah
authors.forename: Lucien
authors.initials: L
authors.lastname: Wald
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
mesh_terms: D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009506:Nevus / Q000453:epidemiology / Q000209:etiology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012880:Skin Pigmentation / Q000528:radiation effects; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000209:etiology*; D014466:Ultraviolet Rays / Q000009:adverse effects*