title: An attempt for fast separation of enantiomers in nano-liquid chromatography and capillary electrochromatography.
abstract: In the present study, an attempt was made to achieve separation of enantiomers within a minute in nano-LC and CEC. In order to achieve this goal several parameters were optimized from the viewpoint of the property of chiral analytes, concentration of the chiral selector in the packing material, capillary dimensions, and separation mode. The enantiomers of several of the applied chiral sulfoxides could be resolved with the analysis time <1 min. Some instrumental obstacles hindering further reduction of analysis time are also highlighted.
authors.affiliation: Institute of Chemical Methodologies, Italian National Research Council (CNR), Monterotondo, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: D'Orazio
authors.affiliation: Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Tbilisi, Georgia.
authors.forename: Rusudan
authors.initials: R
authors.lastname: Kakava
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering "G. Natta" Politecnico di Milano, Milano, Italy.|C.N.R. Istituto di Chimica del Riconoscimento Molecolare (ICRM), Milano, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Volonterio
authors.affiliation: Institute of Chemical Methodologies, Italian National Research Council (CNR), Monterotondo, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Fanali
authors.affiliation: Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Tbilisi, Georgia.
authors.forename: Bezhan
authors.initials: B
authors.lastname: Chankvetadze
mesh_terms: D053801:Capillary Electrochromatography / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods*; D008956:Models, Chemical; D036103:Nanotechnology / Q000379:methods*; D013237:Stereoisomerism; D013454:Sulfoxides / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D013454:Sulfoxides
keywords: CEC; Chiral; Fast enantioseparation; Nano-LC; Sulfoxides