title: Microniosomes for concurrent doxorubicin and iron oxide nanoparticles loading; preparation, characterization and cytotoxicity studies.
abstract: The current work deals with developing a suitable drug delivery system of doxorubicin (DOX) for intraperitoneal chemotherapy using niosomes through formulating non-ionic surfactants consisting of Brij™ 52, span™ 60 and Solulan™ C24. Entrapping the magnetite nanoparticles in the hydrophilic parts of niosomes was accompanied with high-efficient DOX loading by the current novel remote-loading method. Cytotoxicity of the prepared formulations was evaluated in vitro against A549 and PC-12 cell lines using the colorimetric WST-1 assay test. The obtained results revealed that, the cytotoxicity of DOX increased up to 22% especially on A549 cells by the current delivery system.
authors.affiliation: a Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences , Kerman , Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Behnam
authors.affiliation: b Department of General Surgery, School of Medicine , Kerman University of Medical Sciences , Kerman , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rezazadehkermani
authors.affiliation: a Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences , Kerman , Iran.
authors.forename: Saeid
authors.initials: S
authors.lastname: Ahmadzadeh
authors.affiliation: c Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences , Tabriz , Iran.|d Department of Biotechnology , Higher Education Institute of Rab-Rashid , Tabriz , Iran.
authors.forename: Ahad
authors.initials: A
authors.lastname: Mokhtarzadeh
authors.affiliation: e Neuroscience Research Center, Kerman University of Medical Sciences , Kerman , Iran.
authors.forename: Seyed Noureddin
authors.initials: SN
authors.lastname: Nematollahi-Mahani
authors.affiliation: a Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences , Kerman , Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Pardakhty
mesh_terms: D000072283:A549 Cells; D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D006801:Humans; D008081:Liposomes; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D016716:PC12 Cells; D051381:Rats
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D058185:Magnetite Nanoparticles; D004317:Doxorubicin
keywords: Doxorubicin; cytotoxicity; intraperitoneal chemotherapy; magnetite nanoparticles; niosome