title: Subclinical cardiovascular disease assessment and its relationship with cardiovascular risk SCORE in a healthy adult population: A cross-sectional community-based study.
abstract: BACKGROUND
  The aim of this study is to evaluate the relationship and the accuracy of SCORE (Systematic Coronary Risk Evaluation Project) risk correlated to multiple methods for determining subclinical cardiovascular disease (CVD) in a healthy population.
  
  
  METHODS
  This cross-sectional study included 120 completely asymptomatic subjects, with an age range 35-75 years, and randomly selected from the general population. The individuals were evaluated clinically and biochemical, and the SCORE risk was computed. Subclinical atherosclerosis was assessed by various methods: carotid ultrasound for intima-media thickness (cIMT) and plaque detection; aortic pulse wave velocity (aPWV); echocardiography - left ventricular mass index (LVMI) and aortic atheromatosis (AA); ankle-brachial index (ABI).
  
  
  RESULTS
  SCORE mean value was 2.95±2.71, with 76% of subjects having SCORE <5. Sixty-four percent of all subjects have had increased subclinical CVD changes, and SCORE risk score was correlated positively with all markers, except for ABI. In the multivariate analysis, increased cIMT and aPWV were significantly associated with high value of SCORE risk (OR 4.14, 95% CI: 1.42-12.15, p=0.009; respectively OR 1.41, 95% CI: 1.01-1.96, p=0.039). A positive linear relationship was observed between 3 territories of subclinical CVD (cIMT, LVMI, aPWV) and SCORE risk (p<0.0001). There was evidence of subclinical CVD in 60% of subjects with a SCORE value <5.
  
  
  CONCLUSIONS
  As most subjects with a SCORE value <5 have subclinical CVD abnormalities, a more tailored subclinical CVD primary prevention program should be encouraged.
authors.affiliation: Gr. T. Popa University of Medicine and Pharmacy, 16 University Street, Iaşi, Romania.
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Mitu
authors.affiliation: Gr. T. Popa University of Medicine and Pharmacy, 16 University Street, Iaşi, Romania.
authors.forename: Mihai
authors.initials: M
authors.lastname: Roca
authors.affiliation: Gr. T. Popa University of Medicine and Pharmacy, 16 University Street, Iaşi, Romania. Electronic address: floria_mariana@yahoo.com.
authors.forename: Mariana
authors.initials: M
authors.lastname: Floria
authors.affiliation: Gr. T. Popa University of Medicine and Pharmacy, 16 University Street, Iaşi, Romania.
authors.forename: Antoniu Octavian
authors.initials: AO
authors.lastname: Petris
authors.affiliation: Gr. T. Popa University of Medicine and Pharmacy, 16 University Street, Iaşi, Romania.
authors.forename: Mariana
authors.initials: M
authors.lastname: Graur
authors.affiliation: Gr. T. Popa University of Medicine and Pharmacy, 16 University Street, Iaşi, Romania.
authors.forename: Florin
authors.initials: F
authors.lastname: Mitu
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D050197:Atherosclerosis / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D058226:Plaque, Atherosclerotic / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D063177:Pulse Wave Analysis; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: Asintomático; Asymptomatic; Aterosclerosis subclínica; Cardiovascular diseases; Enfermedades cardiovasculares; Puntuación; Riesgo; Risk; SCORE; Subclinical atherosclerosis