title: Acute Management of Moderate-Severe Traumatic Brain Injury.
abstract: Traumatic brain injury (TBI) continues to be a major public health problem. Proposed treatments have not withstood testing in clinical trials because of failure to account for different types of TBI and other weaknesses in trial design. Management goals continue to be prevention and prompt treatment of secondary insults (hypotension, hypoxia, and other physiologic derangements). This goal is best accomplished by careful attention to airway, breathing, circulation, and basic principles of intensive care unit management. Attempts to intervene prophylactically to prevent intracranial hypertension or other complications have not been beneficial and may even have deleterious effects.
authors.affiliation: Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, 6th Floor, PO Box 980631, Richmond, VA 23298-0631, USA.
authors.forename: Wittstatt Alexandra
authors.initials: WA
authors.lastname: Whitaker-Lea
authors.affiliation: Department of Neurosurgery, Virginia Commonwealth University, 417 North 11th Street, 6th Floor, PO Box 980631, Richmond, VA 23298-0631, USA. Electronic address: avaladka@gmail.com.
authors.forename: Alex B
authors.initials: AB
authors.lastname: Valadka
mesh_terms: D000070642:Brain Injuries, Traumatic / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D002534:Hypoxia, Brain / Q000209:etiology / Q000517:prevention & control; D015601:Injury Severity Score; D019586:Intracranial Hypertension / Q000209:etiology / Q000517:prevention & control; D008991:Monitoring, Physiologic
keywords: Intracranial pressure; Management; Outcome; Traumatic brain injury