title: Frequent hemodialysis: history of the modality and assessment of outcomes.
abstract: About 660,000 individuals have end-stage renal disease in the USA, the vast majority of whom are receiving standard, in-center, thrice-weekly hemodialysis (HD). The morbidity and mortality among patients receiving standard HD remain unacceptably high. Studies conducted over the past two decades have provided a substantial amount of information on the advantages and drawbacks of providing more frequent HD treatment, either in-center or at home. In this article I summarize these studies, focusing special attention on the randomized, cross-over study assessing outcomes in children who received either frequent, in-center HD or traditional, thrice-weekly, in-center HD performed by Laskin et al. (Pediatr Nephrol doi: 10.1007/s00467-017-3656-x , 2017).
authors.affiliation: Center for Devices and Radiological Health, Food and Drug Administration, 10993 New Hampshire Avenue, Building 66-G252, Silver Spring, MD, 20994, USA. douglas.silverstein@fda.hhs.gov.
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Silverstein
mesh_terms: D002648:Child; D018592:Cross-Over Studies; D006801:Humans; D007676:Kidney Failure, Chronic; D009398:Nephrology; D010865:Pilot Projects; D006435:Renal Dialysis; D013997:Time Factors
keywords: Children; End-stage kidney disease; Frequency; Hemodialysis