title: Circulating pancreatic stellate (stromal) cells in pancreatic cancer-a fertile area for novel research.
abstract: Pancreatic stellate cells (PSCs) are known to play an important role in facilitating pancreatic cancer progression-both in terms of local tumour growth as well as the establishment of metastases. We have previously demonstrated that PSCs from the primary cancer seed to distant metastatic sites. We therefore hypothesise that PSCs circulate along with pancreatic cancer cells (circulating tumour cells-CTCs) to help create a growth permissive microenvironment at distant metastatic sites. This review aims to explore the concept of circulating PSCs in pancreatic cancer and suggests future directions for research in this area.
authors.affiliation: Pancreatic Research Group, South Western Sydney Clinical School,University of New South Wales, and Ingham Institute of Applied Medical Research, Australia and.
authors.forename: Tony C Y
authors.initials: TCY
authors.lastname: Pang
authors.affiliation: Pancreatic Research Group, South Western Sydney Clinical School,University of New South Wales, and Ingham Institute of Applied Medical Research, Australia and.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Pancreatic Research Group, South Western Sydney Clinical School,University of New South Wales, and Ingham Institute of Applied Medical Research, Australia and.
authors.forename: Srinivasa
authors.initials: S
authors.lastname: Pothula
authors.affiliation: Centre for Circulating Tumour Cell Diagnostics and Research, InghamInstitute for Applied Medical Research, South Western Sydney Clinical School, University of New South Wales, and School ofMedicine, Western Sydney University, Australia.
authors.forename: Therese
authors.initials: T
authors.lastname: Becker
authors.affiliation: Pancreatic Research Group, South Western Sydney Clinical School,University of New South Wales, and Ingham Institute of Applied Medical Research, Australia and.
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
authors.affiliation: Pancreatic Research Group, South Western Sydney Clinical School,University of New South Wales, and Ingham Institute of Applied Medical Research, Australia and.
authors.forename: Romano C
authors.initials: RC
authors.lastname: Pirola
authors.affiliation: Pancreatic Research Group, South Western Sydney Clinical School,University of New South Wales, and Ingham Institute of Applied Medical Research, Australia and.
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Wilson
authors.affiliation: Pancreatic Research Group, South Western Sydney Clinical School,University of New South Wales, and Ingham Institute of Applied Medical Research, Australia and.
authors.forename: Minoti V
authors.initials: MV
authors.lastname: Apte
mesh_terms: D000818:Animals; D002450:Cell Communication; D006801:Humans; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D058954:Pancreatic Stellate Cells / Q000473:pathology*; D017154:Stromal Cells; D059016:Tumor Microenvironment