title: Antimicrobial susceptibility of pathogens isolated from surgical site infections in Japan: Comparison of data from nationwide surveillance studies conducted in 2010 and 2014-2015.
abstract: A nationwide survey was conducted in Japan from 2014 to 2015 to investigate the antimicrobial susceptibility of pathogens isolated from surgical site infections (SSI). The resulting data were compared with that obtained in an earlier survey, conducted in 2010. Seven main organisms were collected, and 883 isolates were studied. A significant reduction in methicillin resistance was observed among Staphylococcus aureus isolates, dropping from 72.5% in 2010 to 53.8% in 2014-2015 (p < 0.001). MRSA isolates with a vancomycin minimum inhibitory concentration (MIC) of 2 μg/mL accounted for 1.2% of all MRSA isolates, which was significantly lower than in 2010 (9.7%, p = 0.029). Of the Escherichia coli isolates, 23.0% produced an extended spectrum β-lactamase (ESBL) in the 2014-2015 survey, which was a significant increase from 9.5% in 2010 (p = 0.011). The geometric mean MICs for ESBL-producing isolates were 0.07 μg/mL for meropenem, 9.51 μg/mL for tazobactam/piperacillin, 0.15 μg/mL for flomoxef, and 1.56 μg/mL for gentamycin. There was a significant increase in the isolation rate of non-fragilis Bacteroides among Bacteroides fragilis group species between the two study periods (35.2% vs. 53.1%, p = 0.007). More than 90% of isolates belonging to the B. fragilis group remained susceptible to tazobactam/piperacillin, meropenem, and metronidazole. In contrast, lower levels of susceptibility were observed for cefmetazole (49.6%), moxifloxacin (61.9%), and clindamycin (46.9%). Non-fragilis Bacteroides isolates had lower rates of antibiotic susceptibility compared with B. fragilis. Overall, the surveillance data clarified trends in antimicrobial susceptibility for organisms commonly associated with SSI.
authors.affiliation: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Hyogo College of Medicine, Hyogo, Japan. Electronic address: takesuey@hyo-med.ac.jp.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takesue
authors.affiliation: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Department of Surgery, Toho University Medical Center Ohashi, Tokyo, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kusachi
authors.affiliation: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Aichi Medical University Hospital, Aichi, Japan.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
authors.affiliation: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.affiliation: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Watanabe
authors.affiliation: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyota
authors.affiliation: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwata
authors.affiliation: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Disease (JAID) and the Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Kaku
authors.affiliation: Kitasato University Institute, Tokyo, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hanaki
authors.affiliation: Japan Society for Surgical Infection, Tokyo, Japan; Department of Surgery, Toho University Medical Center Ohashi, Tokyo, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Sumiyama
authors.affiliation: Japan Society for Surgical Infection, Tokyo, Japan; Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
authors.affiliation: Department of Surgery, Surgical Oncology & Science Sapporo Medical University, Hokkaido, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Mizuguchi
authors.affiliation: Department of Surgery, Teine Keijinkai Hospital, Hokkaido, Japan.
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Ambo
authors.affiliation: Iwate Medical University, Iwate, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Konosu
authors.affiliation: Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ishibashi
authors.affiliation: Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital, Chiba, Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Matsuda
authors.affiliation: National Defense Medical College, Saitama, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hase
authors.affiliation: NTT Medical Center Tokyo, Tokyo, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Harihara
authors.affiliation: Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Okabayashi
authors.affiliation: Department of Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
authors.forename: Shiko
authors.initials: S
authors.lastname: Seki
authors.affiliation: Department of Surgery, Kouseiren Takaoka Hospital, Toyama, Japan.
authors.forename: Takuo
authors.initials: T
authors.lastname: Hara
authors.affiliation: Department of Surgery and Science, University of Toyama, Toyama, Japan.
authors.forename: Koshi
authors.initials: K
authors.lastname: Matsui
authors.affiliation: Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Matsuo
authors.affiliation: Department of Innovative Surgery, Mie University Graduate School of Medicine, Mie, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Kubo
authors.affiliation: Osaka Medical College, Department of General and Gastroenterological Surgery, Osaka, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Uchiyama
authors.affiliation: Department of Surgery, Osaka Rosai Hospital, Osaka, Japan.
authors.forename: Junzo
authors.initials: J
authors.lastname: Shimizu
authors.affiliation: Saki City Medical Center, Osaka, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Kawabata
authors.affiliation: Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohge
authors.affiliation: Department of Surgery, Mazda Hospital, Mazda Motor Corporation, Hiroshima, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Akagi
authors.affiliation: Yamaguchi University, Yamaguchi, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Oka
authors.affiliation: Tottori University Faculty of Medicine, Tottori, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Wakatsuki
authors.affiliation: University of Occupational and Environmental Health, Fukuoka, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Department of Surgery, Gastroenterology and Hepatology Center, Kitakyushu City Yahata Hospital, Fukuoka, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Okamoto
authors.affiliation: Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic susceptibility; Bacteroides fragilis group; Surgical site infections; Surveillance