title: Considerations on the Relevance of Cerebral Fusiform Aneurysms Observed During HIV Infection.
abstract: Human immunodeficiency virus (HIV)-associated ectatic cerebral vasculitis (HIV-AECV) is a rare form of vasculitis with diffuse fusiform aneurysms. Its pathophysiology remains poorly understood. Although extensively described in children, it is still incompletely studied in adults. Our objective was to present five adult cases with emphasis on imaging findings and long-term evolution. From 2006 to 2014, we included 5 HIV-infected patients presenting with fusiform cerebral aneurysms. Vessels abnormalities were assessed with brain computed tomography (CT) angiography, magnetic resonance angiography (MRA) and/or digital subtraction angiography (DSA). All patients had MR assessment of the brain. Clinical and biological data were analyzed. Fusiform aneurysms of carotid terminations extending to middle and anterior cerebral arteries were bilateral in three patients and unilateral in one. More distal fusiform aneurysms were observed in four patients and saccular aneurysms in two patients, two patients suffered from ischemic lesions while none experienced hemorrhage. Unlike recent reviews, our study underlines the low hemorrhagic potential of HIV-AECV and long-term follow-up suggests a monophasic evolution under antiretroviral medication.
authors.affiliation: Neuroradiology Department, APHP, Hôpital Pitié-Salpêtrière, 47-83 bvd de l'Hôpital, 75013, Paris, France. bruno.law-ye@aphp.fr.|Pierre et Marie Curie Faculty of Medicine, Sorbonne Universités, Paris, France. bruno.law-ye@aphp.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: Law-Ye
authors.affiliation: Radiology Department, APHP, Hôpital Raymond Poincaré, Garches, France.|Paris Ile-de-France Ouest Faculty of Medicine, Université de Versailles, Saint-Quentin-en-Yvelines, France.|CIC 1429, Raymond Hôpital Raymond Poincaré, Garches, France.
authors.forename: Robert-Yves
authors.initials: RY
authors.lastname: Carlier
authors.affiliation: Radiology Department, APHP, Hôpital Raymond Poincaré, Garches, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Richard
authors.affiliation: Neuroradiology Department, APHP, Fondation Ophtalmologique Adolphe de Rotschild, Paris, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Blanc
authors.affiliation: Rehabilitation Department, APHP, Hôpital Raymond Poincaré, Garches, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Jourdan
authors.affiliation: Infectious Diseases Department, APHP, Hôpital Raymond Poincaré, Garches, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: de Truchis
authors.affiliation: Radiology Department, APHP, Hôpital Saint-Antoine, Paris, France.
authors.forename: Flore
authors.initials: F
authors.lastname: Viry
authors.affiliation: Neuroradiology Department, APHP, Hôpital Pitié-Salpêtrière, 47-83 bvd de l'Hôpital, 75013, Paris, France.|Pierre et Marie Curie Faculty of Medicine, Sorbonne Universités, Paris, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Dormont
authors.affiliation: Neuroradiology Department, APHP, Hôpital Pitié-Salpêtrière, 47-83 bvd de l'Hôpital, 75013, Paris, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Leclercq
authors.affiliation: Neuroradiology Department, APHP, Hôpital Pitié-Salpêtrière, 47-83 bvd de l'Hôpital, 75013, Paris, France.|Pierre et Marie Curie Faculty of Medicine, Sorbonne Universités, Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Clarençon
mesh_terms: D000328:Adult; D015901:Angiography, Digital Subtraction; D002533:Cerebral Angiography; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Acquired immunodeficiency syndrome; Cerebral vasculitis; Circle of Willis; Fusiform aneurysm; Human immunodeficiency virus