title: High-density speckle contrast optical tomography (SCOT) for three dimensional tomographic imaging of the small animal brain.
abstract: High-density speckle contrast optical tomography (SCOT) utilizing tens of thousands of source-detector pairs, was developed for in vivo imaging of blood flow in small animals. The reduction in cerebral blood flow (CBF) due to local ischemic stroke in a mouse brain was transcanially imaged and reconstructed in three dimensions. The reconstructed volume was then compared with corresponding magnetic resonance images demonstrating that the volume of reduced CBF agrees with the infarct zone at twenty-four hours.
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Barcelona, Spain. Electronic address: tanja.dragojevic@icfo.eu.
authors.forename: Tanja
authors.initials: T
authors.lastname: Dragojević
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Barcelona, Spain.
authors.forename: Hari M
authors.initials: HM
authors.lastname: Varma
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Barcelona, Spain.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Hollmann
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Barcelona, Spain.
authors.forename: Claudia P
authors.initials: CP
authors.lastname: Valdes
authors.affiliation: Department of Radiology, Washington University School of Medicine,St. Louis, MO 63110, USA; Department of Physics, Washington University, St. Louis, MO 63130, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Culver
authors.affiliation: Department of Brain Ischemia and Neurodegeneration, Insitut d'Investigacions Biomèdiques de Barcelona (IIBB), Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain; Àrea de Neurociències, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Justicia
authors.affiliation: ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08015 Barcelona, Spain.
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
mesh_terms: D000465:Algorithms; D000818:Animals; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008810:Mice, Inbred C57BL; D012815:Signal Processing, Computer-Assisted; D020521:Stroke / Q000000981:diagnostic imaging* / Q000503:physiopathology; D041622:Tomography, Optical / Q000379:methods*
keywords: (110.3010) Image reconstruction techniques; (110.6150) Speckle imaging; (170.3880) Medical and biological imaging; OCIS codes