title: Assessment of intraocular pressure sensing using an implanted reflective flexible membrane.
abstract: Glaucoma is a neurodegenerative condition that is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is the main cause for the development of the disease. The symptoms of this form, such as deterioration of vision and scotomas (loss of visual fields), appear in the latter stages of the disease. Therefore, an IOP monitoring device is needed for better, simpler, and faster diagnosis, and to enable a fast treatment response. We present a theoretical assessment as well as preliminary experimental results of a simple approach for easy, optical, IOP self-monitoring. It is based on a polydimethylsiloxane membrane coated with a reflective layer and a Hartmann–Shack wavefront sensor. Nearly linear correlation is found between membrane deformation and Zernike coefficients representing defocus primary spherical aberration, with high sensitivity and negligible dependence on the measurement distance. The proposed device is expected to provide an accurate IOP measurement resolution of less than ± 0.2 ?? mm ? Hg with a pressure dependence on working distances < 0.7 ?? mm ? Hg / cm for a thick membrane; the corresponding values for a thin membrane are ± 0.45 ?? mm ? Hg and < 0.6 ?? mm ? Hg / cm , respectively, at typical IOP values—up to 40 mm Hg.
authors.affiliation: Ben-Gurion University of the Negev, Ilse Katz Institute for Nanoscale Science and Technology, Department of Electro-Optic Engineering, Beer-Sheva, Israel.
authors.forename: Andrey
authors.initials: A
authors.lastname: Nazarov
authors.affiliation: Ben-Gurion University of the Negev, Soroka University Medical Center, Department of Ophthalmology, Beer-Sheva, Israel.
authors.forename: Boris
authors.initials: B
authors.lastname: Knyazer
authors.affiliation: Ben-Gurion University of the Negev, Soroka University Medical Center, Department of Ophthalmology, Beer-Sheva, Israel.
authors.forename: Tova
authors.initials: T
authors.lastname: Lifshitz
authors.affiliation: Ben-Gurion University of the Negev, Department of Material Engineering, Beer-Sheva, Israel.
authors.forename: Mark
authors.initials: M
authors.lastname: Schvartzman
authors.affiliation: Ben-Gurion University of the Negev, Ilse Katz Institute for Nanoscale Science and Technology, Department of Electro-Optic Engineering, Beer-Sheva, Israel.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Abdulhalim
mesh_terms: D002138:Calibration; D003198:Computer Simulation; D003941:Diagnostic Techniques, Ophthalmological; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D005901:Glaucoma / Q000000981:diagnostic imaging*; D006801:Humans; D007429:Intraocular Pressure; D057230:Limit of Detection; D016014:Linear Models; D008567:Membranes, Artificial; D011312:Pressure; D019736:Prostheses and Implants; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; C013830:baysilon