title: Very Low Volume Sprint Interval Exercise Suppresses Subjective Appetite, Lowers Acylated Ghrelin, and Elevates GLP-1 in Overweight Individuals: A Pilot Study.
abstract: High-intensity exercise has been shown to elicit a transient suppression of appetite and create a more anorexigenic profile of appetite-associated hormones. It is yet to be fully elucidated whether such a response is observed following very low-volume, intermittent exercise at supramaximal intensity in those who are overweight. Eight overweight individuals (BMI 27.7 ± 1.7 kg·m²) completed resting (REST) and exercise (EX) trials in a counterbalanced order. EX consisted of 4 × 30 s "flat-out" cycling on an ergometer (adapted Wingate test). Two hours post-exercise (or REST), participants were presented with anad libitummeal. Subjective appetite measures and blood samples were obtained throughout. Subjective appetite, measured using VAS, was significantly lower immediately after exercise compared with REST (38.0 ± 28.5 mm vs. 75.1 ± 26.2 mm,p= 0.018,d= 1.09). This difference remained significant 30 min post-exercise. Acylated ghrelin concentration was suppressed in EX compared with REST immediately post-exercise (113.4 ± 43.0 pg·mL-1vs. 189.2 ± 91.8 pg·mL-1,p= 0.03,d= 1.07) and remained lower until thead libitumtest-meal. Area-under-the-curve for GLP-1 concentration was significantly greater for EX, versus REST. There was no difference in absoluteadlibitumintake or relative energy intake. As little as 4 × 30 s of "flat-out" cycling was sufficient to elicit a transient suppression of appetite and an enduring suppression of plasma acylated ghrelin. Nonetheless, food intake 2-h post-exercise was unaffected.
authors.affiliation: School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK. a.j.holliday@leedsbeckett.ac.uk.|Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds LS6 3QS, UK. a.j.holliday@leedsbeckett.ac.uk.
authors.forename: Adrian
authors.initials: A
authors.lastname: Holliday
authors.affiliation: School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham B15 2TT, UK. a.k.blannin@bham.ac.uk.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Blannin
mesh_terms: D000215:Acylation; D000328:Adult; D001066:Appetite; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D018592:Cross-Over Studies; D004032:Diet; D015444:Exercise; D005260:Female; D054439:Ghrelin / Q000097:blood*; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood*; D010865:Pilot Projects; D012146:Rest; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D054439:Ghrelin; D052216:Glucagon-Like Peptide 1
keywords: appetite hormones; food intake; high-intensity intermittent exercise; hunger; satiety