title: Association of 6-year waist circumference gain and incident hypertension.
abstract: The risk of incident hypertension with gain in waist circumference (WC) has not been fully addressed among Chinese adults.
  
  
  
  A total of 10 265 non-hypertensive participants ≥18 years old who underwent health examinations in rural China were recruited in 2007-2008 and followed up in 2013-2014. Participants were classified by gender according to categories of per cent WC gain at follow-up: ≤-2.5%, -2.5% to 2.5%, 2.5% to 5% and >5%. Relative risk (RR) and 95% CI values for effect of WC gain on the incident hypertension were calculated by using modified Poisson regression models.
  
  
  
  During 6 years of follow-up, we identified 2027 hypertension cases (1213 women). From baseline to follow-up, the prevalence of abdominal obesity increased from 21.1% to 29.6% for men and 49.8% to 61.9% for women. As compared with participants who were not abdominally obese at both baseline and follow-up, both genders who were abdominally obese at follow-up showed greater risk of hypertension regardless of abdominal obesity status at baseline. Compared with the reference group of -2.5% to 2.5% change in WC, with >5% WC gain, risk of incident hypertension was increased for men (RR=1.34, 95% CI 1.15 to 1.57) and women (RR=1.28, 95% CI 1.10 to 1.50). The hypertension risk decreased for men with WC loss ≥2.5% (RR=0.81, 95% CI 0.67 to 0.98).
  
  
  
  Abdominal obesity is seriously prevalent in China. The risk of hypertension increased significantly with increasing WC for both genders in a rural Chinese population.
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.|The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.|The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.
authors.forename: Xinping
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.
authors.forename: Chongjian
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.|Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.|The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.|Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.|The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.
authors.forename: Bingyuan
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.|Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.|The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.|The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.
authors.forename: Junmei
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.|Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.|The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, Republic of China.
authors.forename: Chengyi
authors.initials: C
authors.lastname: Han
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Pang
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, Republic of China.
authors.forename: Tianping
authors.initials: T
authors.lastname: Feng
authors.affiliation: Department of Prevention and Health Care, Military Hospital of Henan Province, Zhengzhou, Henan, Republic of China.
authors.forename: Jingzhi
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, Republic of China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Hu
mesh_terms: D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D050177:Overweight / Q000150:complications* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D055105:Waist Circumference; D015430:Weight Gain
keywords: Epidemiology; Hypertension; Obesity