title: SCUBE1: a promising biomarker in renal cell cancer.
abstract: OBJECTIVE
  To investigate the efficacy of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) as a novel biomarker of renal tumors.
  
  
  METHODS
  48 individuals were included in the study. The patient group (Group-1) consisted of 23 subjects diagnosed with renal tumor, and the control group (Group-2) of 25 healthy individuals. Patients diagnosed with renal tumor received surgical treatment consisting of radical or partial nephrectomy. Blood specimens were collected following overnight fasting. Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1), soluble urokinase plasminogen activator receptor (suPAR) and carbonic anhydrase IX (CA IX) levels were measured from plasma samples. Patients in groups 1 and 2 were compared in terms of these biochemical parameters.
  
  
  RESULTS
  The 23-member renal tumor group was made up of 17 (73.91%) male and 6 (26.08%) female patients with a mean age of 58.5±15.7 years (range 25 to 80). The 24-member healthy control group was made up of 16 (64%) male and 9 (36%) female subjects with a mean age of 52.4±9.12 years (range 40 to 67). Analysis revealed significant elevation in SCUBE-1 levels in the renal tumor group (p=0.005). No significant differences were detected between the groups with regard to CA IX or suPAR measurements (p=0.062 vs. p=0.176).
  
  
  CONCLUSIONS
  SCUBE-1 appears to represent a promising biomarker in the diagnosis and follow-up of patients with renal tumor.
authors.affiliation: Department of Urology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Ersagun
authors.initials: E
authors.lastname: Karagüzel
authors.affiliation: Program of Medical Laboratory Techniques, Karadeniz Technical University, Vocational School of Health Sciences, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Menteşe
authors.affiliation: Department of Urology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: İlke O
authors.initials: İO
authors.lastname: Kazaz
authors.affiliation: Department of Nutrition and Dietetics, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Demir
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Asım
authors.initials: A
authors.lastname: Örem
authors.affiliation: Department of Urology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Ali Ertan
authors.initials: AE
authors.lastname: Okatan
authors.affiliation: Department of Chemistry and Chemical Processing Technology, Ordu University, Ulubey Vocational School, Ordu, Turkey.
authors.forename: Diler Us
authors.initials: DU
authors.lastname: Altay
authors.affiliation: Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
authors.forename: Serap Özer
authors.initials: SÖ
authors.lastname: Yaman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D002135:Calcium-Binding Proteins; D000071231:Carbonic Anhydrase IX / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000175:diagnosis; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; D055293:Receptors, Urokinase Plasminogen Activator; C469998:SCUBE1 protein, human; D000071231:Carbonic Anhydrase IX
keywords:  Biomarkers; Carcinoma, Renal Cell 