title: Synthesis of 2,3-Dihydrobenzofurans via the Palladium Catalyzed Carboalkoxylation of 2-Allylphenols.
abstract: A new Pd-catalyzed alkene carboalkoxylation strategy for the preparation of 2,3-dihydrobenzofurans is described. This method effects the coupling of readily available 2-allylphenol derivatives with aryl triflates to generate a wide range of functionalized 2,3-dihydrobenzofurans in good yields and diastereoselectivities (up to >20:1). Use of newly developed reaction conditions that promoteanti-heteropalladation of the alkene is essential in order to generate products in high yield.
authors.affiliation: University of Michigan, Department of Chemistry, 930 N. University Ave., Ann Arbor, MI, 48109-1055, USA.
authors.forename: Johnathon T
authors.initials: JT
authors.lastname: Hutt
authors.affiliation: University of Michigan, Department of Chemistry, 930 N. University Ave., Ann Arbor, MI, 48109-1055, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Wolfe