title: Thinner Corneas Appear to Have More Striking Effects of Corneal Collagen Crosslinking in Patients with Progressive Keratoconus.
abstract: Purpose.To analyze the outcomes and difference after UVA/riboflavin corneal collagen crosslinking (CXL) in four different corneal thickness groups of patients with progressive keratoconus.Methods.Retrospective study. Eyes with progressive keratoconus after CXL were divided into 4 subgroups as follows: group 1, thinnest corneal thickness (TCT) ≤ 400µm; group 2, 400µm < TCT ≤ 450µm; group 3, 450µm < TCT ≤ 500µm; group 4, TCT ≥ 500µm. Baseline, 6-month, and 12-month visual acuity, corneal topography, TCT, and endothelial cell density were evaluated.Results.The analysis included 123 eyes of 101 patients. At 6 and 12 months after CXL, there was a mean improvement about visual acuity and keratometry values in all patients. There was a reduction in the change of maximum keratometry (Kmax) with the increase of TCT. After 1 year of treatment, it was 3.04 ± 0.75 D in group 1, 2.38 ± 0.51 D in group 2, 1.57 ± 0.35 D in group 3, and 0.31 ± 0.20 D in group 4.Conclusion.CXL is successful in halting the progression of keratoconus and there was a negative linear correlation between TCT andKmax. Advanced cases of progressive keratoconus seemed to obtain more benefits from the flatting effects of CXL.
authors.affiliation: Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China; Department of Ophthalmology, The Second People's Hospital of Liaocheng, Linqing 252600, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Ophthalmology, The Second People's Hospital of Liaocheng, Linqing 252600, China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, The Second People's Hospital of Liaocheng, Linqing 252600, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Dou
authors.affiliation: Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
authors.forename: Guoying
authors.identifier: 0000-0003-0012-2385
authors.initials: G
authors.lastname: Mu