title: Conservation surgery and radiation therapy in early breast cancer - An update.
abstract: BACKGROUND
  Multiple randomised trials and meta-analyses have supported the use of conservative surgery (CS) and radiation therapy (RT) for the treatment of early-stage breast cancer. Following lumpectomy, RT has been shown to decrease the chance of local recurrence and improve overall survival when compared with lumpectomy alone.
  
  
  OBJECTIVE
  This update outlines the rationale and outcomes for CS and RT, whether a subgroup exists in which RT may be safely omitted, the process of RT, common side effects and their management, and the latest techniques in the field.
  
  
  CONCLUSIONS
  Breast conservation remains an effective treatment for breast cancer without a survival disadvantage to a mastectomy. The combination of advanced imaging and fast three-dimensional (3D) radiotherapy planning computer systems have allowed new techniques that deliver RT more accurately, with better tumour control, fewer side effects and improved survival.
authors.forename: Ellen
authors.initials: E
authors.lastname: Tailby
authors.forename: John
authors.initials: J
authors.lastname: Boyages Am
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy / Q000379:methods / Q000592:standards*; D000072700:Conservative Treatment / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome