title: Primary Auditory Cortex is Required for Anticipatory Motor Response.
abstract: The ability of the brain to predict future events based on the pattern of recent sensory experience is critical for guiding animal's behavior. Neocortical circuits for ongoing processing of sensory stimuli are extensively studied, but their contributions to the anticipation of upcoming sensory stimuli remain less understood. We, therefore, used in vivo cellular imaging and fiber photometry to record mouse primary auditory cortex to elucidate its role in processing anticipated stimulation. We found neuronal ensembles in layers 2/3, 4, and 5 which were activated in relationship to anticipated sound events following rhythmic stimulation. These neuronal activities correlated with the occurrence of anticipatory motor responses in an auditory learning task. Optogenetic manipulation experiments revealed an essential role of such neuronal activities in producing the anticipatory behavior. These results strongly suggest that the neural circuits of primary sensory cortex are critical for coding predictive information and transforming it into anticipatory motor behavior.
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.|Department of Physiology, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jingcheng
authors.initials: J
authors.lastname: Li
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Liao
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.|Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Physiology, Third Military Medical University, Chongqing 400038, China.
authors.forename: Nian
authors.initials: N
authors.lastname: Yang
authors.affiliation: Department of Physiology, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Lv
authors.affiliation: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
authors.forename: Haohong
authors.initials: H
authors.lastname: Li
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Lu
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Ding
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xingyi
authors.initials: X
authors.lastname: Li
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Guang
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Han
authors.initials: H
authors.lastname: Qin
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Jin
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Kuan
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Physiology, Third Military Medical University, Chongqing 400038, China.
authors.forename: Chao
authors.initials: C
authors.lastname: He
authors.affiliation: Brain Research Instrument Innovation Center, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Jia
authors.affiliation: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
authors.forename: Shaoqun
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Department of Physiology, Third Military Medical University, Chongqing 400038, China.
authors.forename: Zhian
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Neurobiology, Silberman Institute of Life Sciences and the Edmond and Lily Safra Center for Brain Sciences, Hebrew University, Jerusalem 9190401, Israel.
authors.forename: Israel
authors.initials: I
authors.lastname: Nelken
authors.affiliation: Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China.|CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Chen
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000235:genetics / Q000378:metabolism; D000075402:Channelrhodopsins / Q000235:genetics / Q000378:metabolism; D003214:Conditioning, Classical; D004327:Drinking Behavior; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009042:Motivation / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism; D014161:Transduction, Genetic; D014851:Wakefulness
chemical_list: D000075402:Channelrhodopsins; D010320:Parvalbumins; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1
keywords: 2-photon imaging; anticipatory motor response; predictive coding; primary auditory cortex; rhythmic sound stimulation