title: Regio- and Diastereoselective Cross-Dehydrogenative Coupling of Tetrahydropyridines with 1,3-Dicarbonyl Compounds.
abstract: A regio- and diastereoselective cross-dehydrogenative coupling of N-carbamoyl tetrahydropyridines with a variety of 1,3-dicarbonyl compounds is described. The method exhibits good functional group tolerance, diastereoselectively generating cis-2,6- or cis-2,4-substituted tetrahydropyridines by using different types of 1,3-dicarbonyls. Moreover, a two-step sequence involving diastereoselective cross-dehydrogenative coupling followed by epimerization was also developed, allowing facile access to trans-2,6-substituted tetrahydropyridines as single isomers. Applications in natural product synthesis and divergent analogue preparation were further demonstrated.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Long
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Lu
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Xu
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
authors.forename: Kelian
authors.initials: K
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
authors.forename: Shutao
authors.initials: S
authors.lastname: Qi
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
authors.forename: Yiheng
authors.initials: Y
authors.lastname: He
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Bu
authors.affiliation: School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.|School of Chemistry and Chemical Engineering, Shandong University , Jinan 250100, China.
authors.forename: Lei
authors.identifier: 0000-0002-0839-373X
authors.initials: L
authors.lastname: Liu