title: Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua.
abstract: Three new neolignans, lycocernuasides B-D (1-3), three new serratane triterpenoids, lycernuic ketones D (8) and E (9), and lycernuic A (10), together with six known compounds, were isolated from the 75% aqueous EtOH extract of Palhinhaea cernua. Their structures and absolute configurations were established primarily by NMR, HRESIMS and circular dichroism (CD). All compounds were evaluated the inhibitory activities of xanthine oxidase. Compounds 1-3 displayed moderate inhibitory effects on xanthine oxidase with IC50values of 30.36μM, 42.65μM and 35.33μM, respectively.
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China.
authors.forename: Ping-Sheng
authors.initials: PS
authors.lastname: Xu
authors.affiliation: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Lei-Hong
authors.initials: LH
authors.lastname: Tan
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Zhen-Xing
authors.initials: ZX
authors.lastname: Zou
authors.affiliation: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Yi-Kun
authors.initials: YK
authors.lastname: Wang
authors.affiliation: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: Long
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China.
authors.forename: Gan
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China.
authors.forename: Guang
authors.initials: G
authors.lastname: Li
authors.affiliation: Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China. Electronic address: xukp395@csu.edu.cn.
authors.forename: Kang-Ping
authors.initials: KP
authors.lastname: Xu
authors.affiliation: Xiangya Hospital of Central South University, Changsha 410008, PR China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR China. Electronic address: tgs395@csu.edu.cn.
authors.forename: Gui-Shan
authors.initials: GS
authors.lastname: Tan
mesh_terms: D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D029542:Lycopodiaceae / Q000737:chemistry*; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D017705:Lignans; D014315:Triterpenes; D014969:Xanthine Oxidase
keywords: Neolignan; Palhinhaea cernua; Serratane triterpenoid; Xanthine oxidase