title: [Radiation-induced bronchiolitis obliterans with organizing pneumonia].
abstract: Bronchiolitis obliterans with organizing pneumonia is an inflammatory reaction that can occur as a consequence of various pulmonary affections. Radiotherapy is not the sole and systematic cause of bronchiolitis obliterans with organizing pneumonia. Radiation-induced should not be confused with post-radiation, dose-dependent, inflammatory pulmonary fibrosis, which is non-immunological and located within the irradiation field. The role of immunity, local inflammation and individual radiosensitivity in bronchiolitis obliterans with organizing pneumonia is not well defined. Bronchiolitis obliterans with organizing pneumonia represents 1% of irradiated patients with breast cancer. It results in fever (flu-like symptoms), a rather dry cough and dyspnea. In the post-radiation context, bronchiolitis obliterans with organizing pneumonia may be diagnosed several months and up to a year after breast irradiation. The treatment consists of prolonged steroids or immunosuppressants, which do not prevent chronicity in 15% of patients and death in up to 5% of cases, the remaining 80% of patients healing without sequelae.
authors.affiliation: Département de pharmacie, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France.
authors.forename: J
authors.initials: J
authors.lastname: Ducray
authors.affiliation: Département d'oncologie médicale, hôpital Louis-Pasteur, 4, rue Claude-Bernard, 28630 Le Coudray, France.
authors.forename: S
authors.initials: S
authors.lastname: Vignot
authors.affiliation: Centre d'imagerie médicale, 47, boulevard du Pont-Rouge, 15000 Aurillac, France.
authors.forename: A
authors.initials: A
authors.lastname: Lacout
authors.affiliation: Service de radiothérapie, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France.
authors.forename: I
authors.initials: I
authors.lastname: Pougnet
authors.affiliation: Service d'imagerie médicale, polyclinique Les Fleurs, 332, avenue Frédéric-Mistral, 83190 Ollioule, France.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Marcy
authors.affiliation: Service de radiologie, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France.
authors.forename: C
authors.initials: C
authors.lastname: Chapellier
authors.affiliation: UMR1052, Inserm, 28, rue Laennec, 69008 Lyon, France.
authors.forename: N
authors.initials: N
authors.lastname: Foray
authors.affiliation: Service d'oncologie médicale, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France.
authors.forename: A
authors.initials: A
authors.lastname: Creisson
authors.affiliation: Service de radiothérapie, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France. Electronic address: jthariat@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Thariat
mesh_terms: D000368:Aged; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D015995:Prevalence; D011832:Radiation Injuries / Q000150:complications*
keywords: BOOP; Breast cancer; Bronchiolite oblitérante avec organisation pneumonique; Bronchiolitis obliterans with organizing pneumonia; Cancer du sein; Corticostéroïdes; Radiation therapy; Radiothérapie; Steroid