title: Maternal immunization.
abstract: Pregnant women, neonates, and infants are at higher risk for severe infections due to vaccine-preventable diseases. Very young infants rarely respond well to vaccination due to poor immunogenicity and interference from maternal antibody. Maternal immunization protects the mother and fetus from disease and protects the infant through transplacental antibody transfer through the first 6 months of life. Currently, immunizations routinely recommended during pregnancy include inactivated influenza, tetanus toxoid, and acellular pertussis vaccines. Promising maternal vaccine candidates in development include a group B streptococcus vaccine and a respiratory syncytial virus vaccine. Birth Defects Research 109:379-386, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
authors.forename: Helen Y
authors.initials: HY
authors.lastname: Chu
authors.affiliation: Division of Allergy & Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.|Department of Infectious Diseases, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA.
authors.forename: Janet A
authors.initials: JA
authors.lastname: Englund
mesh_terms: D004165:Diphtheria / Q000517:prevention & control; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007114:Immunization; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000517:prevention & control; D010567:Pertussis Vaccine / Q000276:immunology; D011247:Pregnancy; D013742:Tetanus / Q000517:prevention & control; D014611:Vaccination / Q000379:methods*; D014917:Whooping Cough / Q000517:prevention & control
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D007252:Influenza Vaccines; D010567:Pertussis Vaccine
keywords: diphtheria; influenza; maternal immunization; pertussis; tetanus