title: Anti-KIR4.1 Antibodies in Chinese Patients with Central Nervous System Inflammatory Demyelinating Disorders.
abstract: The aim of this study was to explore the frequency of KIR4.1 antibodies in patients with multiple sclerosis (MS) and in control groups using a cell-based assay.
  
  
  
  A transfected HEK-293A cell line expressing KIR4.1 was established to test for the presence of KIR4.1 antibodies in blood serum. We tested 904 subjects, including 188 patients with MS, 264 patients with neuromyelitis optica spectrum disorders (NMOSD), 209 patients with other inflammatory neurologic disease (OIND), 203 patients with other noninflammatory neurological disease (OND), and 40 healthy controls.
  
  
  
  KIR4.1 antibodies were present in 23 of the 188 (12.2%) MS patients, 42 of the 264 (15.9%) NMOSD patients, 32 of the 209 (15.3%) OIND patients, 24 of the 203 (11.8%) OND patients, and 2 of the 40 (5%) healthy controls. There were no significant differences among the MS and control groups (p = 0.279).
  
  
  
  Anti-KIR4.1 antibody, as determined by a cell-based assay, is not a specific biomarker for MS.
authors.affiliation: Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience, Guangzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhong
authors.forename: Junyan
authors.initials: J
authors.lastname: Liang
authors.forename: Ailin
authors.initials: A
authors.lastname: Tao
authors.forename: Linzhan
authors.initials: L
authors.lastname: Wu
authors.forename: Xinguang
authors.initials: X
authors.lastname: Yang
authors.forename: Huiming
authors.initials: H
authors.lastname: Xu
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Huang
authors.forename: Shunzhi
authors.initials: S
authors.lastname: Zhuang
authors.forename: Youming
authors.initials: Y
authors.lastname: Long
authors.forename: Cong
authors.initials: C
authors.lastname: Gao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051401:Aquaporin 4 / Q000276:immunology; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D020278:Demyelinating Autoimmune Diseases, CNS / Q000097:blood* / Q000276:immunology*; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000097:blood / Q000276:immunology; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics / Q000276:immunology*; D014162:Transfection; D055815:Young Adult; D000098854:Kcnj10 Channel
chemical_list: D051401:Aquaporin 4; D001323:Autoantibodies; D000098854:Kcnj10 Channel; D024661:Potassium Channels, Inwardly Rectifying
keywords: Biomarker; Cell-based assay; KIR4.1 antibody; Multiple sclerosis; Neuromyelitis optica spectrum disorders