title: Using gonadotropin-releasing hormone agonist before frozen embryo transfer may improve ongoing pregnancy rates in hyperandrogenic polycystic ovary syndrome women.
abstract: Polycystic ovary syndrome (PCOS), affecting more than 5-10% of woman at reproductive childbearing age, is characterized by anovulation and hyperandrogenism. Frozen-thawed embryo transfer (ET) has been widely used for PCOS women to minimize the risk of ovarian hyperstimulation syndrome. However, the hyperandrogenic status of PCOS women deteriorates endometrial function, which has subsequently increased miscarriage rates in PCOS women. Therefore, we conducted this retrospective study to compare the pregnancy outcomes of hyperandrogenic PCOS women with (n = 29) and without (n = 31, controls) pretreatment of gonadotropin-releasing hormone (GnRH) agonist before frozen-thawed ET. We found that pretreatment with GnRH agonist before frozen-thawed ETs could not significantly improve the clinical pregnancy rate in these hyperandrogenic PCOS women. However, the ongoing pregnancy rate was significantly increased in women with GnRH agonist pretreatment (odds ratio: 3.98, 95% confidence interval: 1.12-14.20, p = 0.033). We concluded that androgen deprivation status due to pretreatment with GnRH agonist might improve the ongoing pregnancy rate in hyperandrogenic PCOS women. Additional large, well-designed prospective studies are worthwhile and necessary.
authors.affiliation: a Department of Obstetrics and Gynecology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.|b Institute of Clinical Medicine, National Yang-Ming University , Taipei , Taiwan.|c School of Medicine, National Yang-Ming University , Taipei , Taiwan.|d School of Medicine, College of Medicine, Kaohsiung Medical University , Kaohsiung , Taiwan.
authors.forename: Hsiao-Wen
authors.initials: HW
authors.lastname: Tsai
authors.affiliation: b Institute of Clinical Medicine, National Yang-Ming University , Taipei , Taiwan.|c School of Medicine, National Yang-Ming University , Taipei , Taiwan.|e Department of Obstetrics and Gynecology , Taipei Veterans General Hospital , Taipei , Taiwan.|f Department of Medical Research , China Medical University Hospital , Taichung , Taiwan.
authors.forename: Peng-Hui
authors.initials: PH
authors.lastname: Wang
authors.affiliation: a Department of Obstetrics and Gynecology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.|c School of Medicine, National Yang-Ming University , Taipei , Taiwan.|g Department of Biological Science , National Sun Yat-sen University , Kaohsiung , Taiwan , and.
authors.forename: Li-Te
authors.initials: LT
authors.lastname: Lin
authors.affiliation: a Department of Obstetrics and Gynecology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.
authors.forename: San-Nung
authors.initials: SN
authors.lastname: Chen
authors.affiliation: a Department of Obstetrics and Gynecology , Kaohsiung Veterans General Hospital , Kaohsiung , Taiwan.|c School of Medicine, National Yang-Ming University , Taipei , Taiwan.|g Department of Biological Science , National Sun Yat-sen University , Kaohsiung , Taiwan , and.|h Department of Pharmacy and Master Program , College of Pharmacy and Health Care, Tajen University , Pingtung County , Taiwan.
authors.forename: Kuan-Hao
authors.initials: KH
authors.lastname: Tsui
mesh_terms: D000328:Adult; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D017588:Hyperandrogenism / Q000503:physiopathology*; D007247:Infertility, Female / Q000503:physiopathology / Q000628:therapy*; D016729:Leuprolide / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D016729:Leuprolide
keywords: Frozen-thawed embryo transfer; hyperandrogenism; polycystic ovary syndrome; pregnancy