title: Genetic association between TAP1 and TAP2 polymorphisms and ankylosing spondylitis: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Ankylosing spondylitis (AS) is a chronic inflammatory joint disease. The transporter associated with antigen processing (TAP) has been identified to play an important role in immune response as well as the HLA-associated diseases. The aim of our meta-analysis was to investigate the contribution of TAP (TAP1 and TAP2) polymorphisms to the risk of AS.
  
  
  METHODS
  Meta-analyses were performed between 2 polymorphisms in TAP1 (TAP1-333, -637) and 3 polymorphisms in TAP2 (TAP2-379, -565, and -665) and AS.
  
  
  RESULTS
  The meta-analyses were involved with 6 studies with 415 cases and 659 controls. Significant association was found between TAP1-333Val, TAP1-637Gly, and TAP2-565Thr and AS compared with combined control group (TAP1-333Val: p = 0.009, OR = 1.40, 95% CI 1.09-1.80; TAP1-637Gly: p = 0.002, OR = 1.48, 95% CI 1.15-1.91; p = 0.03, OR = 1.38, 95% CI 1.04-1.84). Subgroup analysis shown that significant association was only found in AS when compared with HLA-B27-negative controls (TAP1-333Val: p = 0.004, OR = 1.53, 95% CI 1.14-2.06; TAP1-637Gly: p = 0.004, OR = 1.52, 95% CI 1.15-2.02; p = 0.02, OR = 1.56, 95% CI 1.09-2.24), but not in AS when compared with HLA-B27-positive controls (p > 0.05). Moreover, no significant associations were found between haplotypes in TAP1 and TAP2 in both the combined and the subgroup analyses (p > 0.05).
  
  
  CONCLUSIONS
  TAP1-333Val, TAP1-637Gly, and TAP2-565Thr were likely to be associated with AS.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Suzhou University, Suzhou, 215000, People's Republic of China.|Department of Orthopedics, Changshu First People's Hospital, Changshu, People's Republic of China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Suzhou University, Suzhou, 215000, People's Republic of China.
authors.forename: Genlin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, Changshu First People's Hospital, Changshu, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, People's Republic of China.
authors.forename: Lianghui
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Suzhou University, Suzhou, 215000, People's Republic of China. hecsmu@126.com.
authors.forename: Huilin
authors.initials: H
authors.lastname: Yang
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2 / Q000235:genetics*; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D013167:Spondylitis, Ankylosing / Q000235:genetics*
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; C073119:TAP1 protein, human; C071692:TAP2 protein, human
keywords: Ankylosing spondylitis (AS); Human leukocyte antigen-B27 HLA-B27; Meta-analysis; Transporter associated with antigen processing (TAP)