title: Porous Peptide Complexes by a Folding-and-Assembly Strategy.
abstract: Concerted folding and assembly processes are necessary for protein self-assembly, yet such a concerted strategy has rarely been attempted by synthetic chemists. In this work, we have created a new porous peptide structure through a coordination-driven folding-and-assembly strategy. A porous framework with 1.5 nm-sized pores and a PIIhelical peptide scaffold was successfully obtained by complexation of AgNTf2and tripeptide ligands containing the Gly-Pro-Pro sequence. The pores were modified in various ways with retention of the latent PIIhelical conformation of the peptide ligand.
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Sawada
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Motoya
authors.initials: M
authors.lastname: Yamagami
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Akinaga
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Miyaji
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Fujita
mesh_terms: D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D017510:Protein Folding; D013499:Surface Properties
chemical_list: D010455:Peptides
keywords: coordination; folding; peptide; porous crystal; self-assembly