title: Resolution of liver disease in transient abnormal myelopoiesis with fish oil emulsion.
abstract: Neonates with Down syndrome are at risk of developing transient abnormal myelopoiesis (TAM), which is characterized by transient clonal myeloproliferation of the blast cells. TAM can resolve spontaneously, but some patients die at an early age due to organ failure. Liver fibrosis in TAM is a life-threatening condition, but treatment options have not yet been established. Here, we report on the case of an infant with TAM complicated by liver disease, whose hyperbilirubinemia was successfully ameliorated with omega-3 fatty acid (ω3FA) lipid emulsion. Timely ω3FA lipid emulsion may be a feasible treatment for liver disease in TAM before serious liver damage develops.
authors.affiliation: Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Division of Neonatology, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Amari
authors.affiliation: Division of Neonatology, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsukamoto
authors.affiliation: Division of Neonatology, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tomizawa
authors.affiliation: Department of Pathology, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Yoshioka
authors.affiliation: Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kanamori
mesh_terms: D004314:Down Syndrome / Q000150:complications* / Q000175:diagnosis; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007955:Leukemoid Reaction / Q000150:complications* / Q000175:diagnosis; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*
chemical_list: D005217:Fat Emulsions, Intravenous; D015525:Fatty Acids, Omega-3
keywords: direct bilirubin; liver fibrosis; omega-3 fatty acid lipid emulsion; transient abnormal myelopoiesis; transient myeloproliferative disorder