title: Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer.
abstract: Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.
authors.affiliation: Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Viale Ercolani 4/2, 40138, Bologna, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giunchi
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 677 Avenue, Huntington, MA, 02115, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Jordahl
authors.affiliation: Department of Oncology, Division of Pathology, San Luigi Gonzaga Hospital, Orbassano, area, Regione Gonzole, 10, 10043, Turin, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Bollito
authors.affiliation: Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Giacomo Venezian 1, 20133, Milan, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Colecchia
authors.affiliation: Pathology Department, St Anna Hospital, Via Ravona, 20, 22020, Como, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Patriarca
authors.affiliation: Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Viale Ercolani 4/2, 40138, Bologna, Italy.
authors.forename: Antonietta
authors.initials: A
authors.lastname: D'Errico
authors.affiliation: Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Viale Ercolani 4/2, 40138, Bologna, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Vasuri
authors.affiliation: Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Viale Ercolani 4/2, 40138, Bologna, Italy.
authors.forename: Deborah
authors.initials: D
authors.lastname: Malvi
authors.affiliation: Department of Oncology, Division of Pathology, San Luigi Gonzaga Hospital, Orbassano, area, Regione Gonzole, 10, 10043, Turin, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fornari
authors.affiliation: Pathology Department, University of Modena and Reggio Emilia, Via Università, 4, 41121, Modena, Italy.
authors.forename: Luca Reggiani
authors.initials: LR
authors.lastname: Bonetti
authors.affiliation: Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Viale Ercolani 4/2, 40138, Bologna, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Corti
authors.affiliation: Department of Oncology and Pathology, University of Turin, Via Giuseppe Verdi, 8, 10124, Turin, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Papotti
authors.affiliation: Pathology Department, S. Lazzaro Hospital, Via Pietrino Belli, 26, 12051, Alba, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: DeGiuli
authors.affiliation: Medical Oncology Department, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA.
authors.forename: Massimo
authors.initials: M
authors.lastname: Loda
authors.affiliation: Pathology Department, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, via Conca 71, 60126, Ancona, Italy.
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
authors.affiliation: Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Viale Ercolani 4/2, 40138, Bologna, Italy. michelangelo.fiorentino@aosp.bo.it.
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Fiorentino
authors.affiliation: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 677 Avenue, Huntington, MA, 02115, USA.|Department of Epidemiology, Boston University School of Public Health, 715 Albany Street, T317E, Boston, MA, 02118, USA.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Rider
mesh_terms: D001284:Atrophy / Q000175:diagnosis; D002908:Chronic Disease; D006801:Humans; D008297:Male; D015588:Observer Variation; D011467:Prostate / Q000473:pathology; D019048:Prostatic Intraepithelial Neoplasia / Q000175:diagnosis*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D011472:Prostatitis / Q000175:diagnosis*
keywords: Atrophic lesions; Inflammation; PAH; Prostate