title: Impact of whey proteins on the systemic and local intestinal level of mice with diet induced obesity.
abstract: Obesity is a serious public health problem and being multifactorial is difficult to tackle. Since the intestinal ecosystem's homeostasis is, at least partially, diet-dependent, its modulation may be triggered by food components that are designed to exert a modulatory action leading to a health-promoting effect. Milk whey proteins, are considered as such promising factors since they influence satiation as well as body weight and constitute the source of biologically active peptides which may modulate health status locally and systemically. This way, whey proteins are associated with obesity. Therefore, this paper is aimed at the estimation of the impact of whey proteins using a commercially available whey protein isolate on the physiological response of mice with diet-induced obesity. The physiological response was evaluated on the local-intestinal level, scrutinizing intestinal microbiota as one of the important factors in obesity and on the systemic level, analyzing the response of the organism. Whey proteins brought about the decrease of the fat mass with a simultaneous increase of the lean mass of animals with diet induced obesity, which is a promising, health-promoting effect. Whey proteins also proved to act beneficially helping restore the number of beneficial bifidobacteria in obese animals and decreasing the calorie intake and fat mass as well as the LDL level. Overall, supplementation of the high fat diet with whey proteins acted locally by restoration of the intestinal ecosystem, thus preventing dysbiosis and its effects and also acted systemically by strengthening the organism increasing the lean mass and thus hindering obesity-related detrimental effects.
authors.affiliation: Department of Immunology and Food Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, ul. Tuwima 10, 10-748 Olsztyn, Poland. d.swiatecka@pan.olsztyn.pl.
authors.forename: D
authors.initials: D
authors.lastname: Swiątecka
authors.forename: D
authors.initials: D
authors.lastname: Złotkowska
authors.forename: L H
authors.initials: LH
authors.lastname: Markiewicz
authors.forename: A M
authors.initials: AM
authors.lastname: Szyc
authors.forename: B
authors.initials: B
authors.lastname: Wróblewska
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D002149:Energy Intake; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics / Q000378:metabolism / Q000382:microbiology; D000067816:Whey Proteins / Q000378:metabolism*
chemical_list: D000067816:Whey Proteins