title: THE ROLE OF LOW MOLECULAR WEIGHT HEPARIN IN WOMEN WITH HEREDITARY THROMBOPHILIA FOR GOOD PERINATAL OUTCOME.
abstract: The aim of the study was to establish the importance of low molecular weight
  heparin (LMWH) treatment for good pregnancy outcome in patients with hereditary thrombophilia.
  This retrospective study included 70 patients with inherited thrombophilia who gave birth at Zagreb
  University Hospital Center in the period from January 2014 to January 2015. Fifty-seven women
  were treated and 13 women were not treated with LMWH. Perinatal outcome was significantly better
  in women with hereditary thrombophilia who were treated with heparin during pregnancy as compared
  with women without LMWH (p=0.006). Regardless of heparin therapy, patients with hereditary
  thrombophilia alone had a significantly better perinatal outcome as compared with women who,
  along with hereditary thrombophilia, had a history of habitual abortions (p=0.035) or intrauterine
  fetal death (p=0.033). Women treated with heparin had better perinatal outcome if they were without
  a history of recurrent or non-recurrent fetal loss (p=0.088). In the group without LMWH, perinatal
  outcome was significantly better in women with no history of habitual abortions as compared with
  women with recurrent miscarriages (p=0.047). Administration of LMWH is justified in women with
  hereditary thrombophilia and a history of adverse perinatal outcome.
authors.forename: Vesna
authors.initials: V
authors.lastname: Sokol
authors.forename: Marina
authors.initials: M
authors.lastname: Ivanišević
authors.forename: Mislav
authors.initials: M
authors.lastname: Herman
authors.forename: Josip
authors.initials: J
authors.lastname: Đelmiš
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000517:prevention & control*; D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D019851:Thrombophilia / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight