title: Rotavirus Vaccination and the Risk of Celiac Disease or Type 1 Diabetes in Finnish Children at Early Life.
abstract: Rotavirus infection has been suggested as a trigger of type 1 diabetes (T1D)-related autoimmunity and celiac disease (CD)-related autoimmunity.
  
  
  
  We carried out a nationwide, population-based cohort study evaluating whether prevention of rotavirus infection with vaccination affects the risk of CD and T1D diagnosed during 2009-2014 in Finnish children by comparing vaccinated and unvaccinated children in a cohort born in 2009-2010. Nationwide rotavirus vaccination records were collected from healthcare databases during 2009-2011 and validated for a sample of 495 children born from July 2009 to December 2009. Incident diagnoses of CD and T1D during 2009-2014 in the cohort were identified in the National Care Register.
  
  
  
  The adjusted relative risks (with 95% confidence intervals) were 0.91 (0.69-1.20) for T1D and 0.87 (0.65-1.17) for CD in vaccinated children compared with unvaccinated, suggesting that oral rotavirus vaccination does not alter the risk of CD or T1D during 4-6 years follow-up after vaccination.
  
  
  
  Our results suggest that oral rotavirus vaccination is considered safe in the individuals at risk of CD and T1D.
authors.affiliation: From the *Institute of Clinical Medicine, University of Helsinki, and †Department of Health Protection, National Institute for Health and Welfare, Helsinki, Finland.
authors.forename: Outi
authors.initials: O
authors.lastname: Vaarala
authors.forename: Jukka
authors.initials: J
authors.lastname: Jokinen
authors.forename: Mika
authors.initials: M
authors.lastname: Lahdenkari
authors.forename: Tuija
authors.initials: T
authors.lastname: Leino
mesh_terms: D002446:Celiac Disease / Q000453:epidemiology*; D002675:Child, Preschool; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012400:Rotavirus Infections / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000009:adverse effects*; D014611:Vaccination / Q000009:adverse effects* / Q000706:statistics & numerical data*
chemical_list: D022243:Rotavirus Vaccines