title: Microbiotal-Host Interactions and Hypertension.
abstract: Hypertension, or elevated blood pressure (BP), has been extensively researched over decades and clearly demonstrated to be caused due to a combination of host genetic and environmental factors. Although much research remains to be conducted to pin-point the precise genetic elements on the host genome that control BP, new lines of evidence are emerging to indicate that, besides the host genome, the genomes of all indigenous commensal micro-organisms, collectively referred to as the microbial metagenome or microbiome, are important, but largely understudied, determinants of BP. Unlike the rigid host genome, the microbiome or the "second genome" can be altered by diet or microbiotal transplantation in the host. This possibility is attractive from the perspective of exploiting the microbiotal composition for clinical management of inherited hypertension. Thus, focusing on the limited current literature supporting a role for the microbiome in BP regulation, this review highlights the need to further explore the role of the co-existence of host and the microbiota as an organized biological unit called the "holobiont" in the context of BP regulation.
authors.affiliation: Physiological Genomics Laboratory, Center for Hypertension and Personalized Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio; and.
authors.forename: Sarah
authors.initials: S
authors.lastname: Galla
authors.affiliation: Physiological Genomics Laboratory, Center for Hypertension and Personalized Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio; and.
authors.forename: Saroj
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Physiological Genomics Laboratory, Center for Hypertension and Personalized Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio; and.
authors.forename: Blair
authors.initials: B
authors.lastname: Mell
authors.affiliation: Department of Nutritional Sciences and Medicine, The Pennsylvania State University, University Park, Pennsylvania.
authors.forename: Matam
authors.initials: M
authors.lastname: Vijay-Kumar
authors.affiliation: Physiological Genomics Laboratory, Center for Hypertension and Personalized Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio; and bina.joe@utoledo.edu.
authors.forename: Bina
authors.initials: B
authors.lastname: Joe
mesh_terms: D000818:Animals; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000382:microbiology*; D054892:Metagenome; D051379:Mice; D064307:Microbiota