title: Application of Fischer Indolization under Green Conditions using Deep Eutectic Solvents.
abstract: Indole and its derivatives captured the attention of organic chemists due to their applications in medicinal chemistry. The examples covered here are intricate polycyclic indole derivatives and these include: azapolyquinanes, cyclophanes, spirocycles and other heterocycles. We found that deep eutectic mixture such as L-(+)-tartaric acid (TA) and dimethyl urea (DMU) is useful to prepare complex unnatural indole derivatives. These conditions from time to time produced indole derivatives which are not possible by conventional methods. Various substrates containing multiple carbonyl groups were shown to undergo Fischer indolization (FI) in deep eutectic mixtures and thus expand its scope to a higher level.
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-, 400076, India.
authors.forename: Sambasivarao
authors.initials: S
authors.lastname: Kotha
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-, 400076, India.
authors.forename: Chandravathi
authors.initials: C
authors.lastname: Chakkapalli
keywords: aza-polyquinanes; bis-indole derivatives; cyclophanes; deep eutectic solvents; spirocycles