title: Prognostic significance of ACP5 expression in patients with lung adenocarcinoma.
abstract: BACKGROUND
  Tartrate-resistant acid phosphatase 5 (ACP5), which is essential for bone resorption and osteoclast differentiation, promotes cell motility through the modulation of focal adhesion kinase phosphorylation. This study seeks to elucidate the association of ACP5 expression and the clinicopathologic characteristics of patients with lung adenocarcinoma (AD).
  
  
  METHODS
  The expression of ACP5 was measured by Immunohistochemistry and Western blot analysis in lung AD and matched tumor-adjacent tissues, and the χ2test was applied to analyze the correlation between ACP5 expression and clinicopathologic features. Using the Kaplan-Meier method, univariate and multivariate regression analysis was to explore the correlation between ACP5 expression and overall survival (OS).
  
  
  RESULTS
  We found that ACP5 was frequently upregulated in lung AD tissues. The high expression of ACP5 was significantly related to lymph node status, tumor-node-metastasis (TNM) stage, and differentiation. From the results of univariate survival analysis, it indicated that the patients with high expression of ACP5 expression had a significantly lower OS than the patients with low expression of ACP5 expression. As it showed in Multivariate Cox regression analysis, the high expression of ACP5 expression was an independent prognostic factor for OS.
  
  
  CONCLUSIONS
  Our results suggest that high expression of ACP5 correlates with tumor progression and may serve as a potential prognostic biomarker in lung AD.
authors.affiliation: Department of Radiotherapy, Cangzhou Central Hospital, Cangzhou, Hebei, 061001, China.
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Gao
authors.affiliation: Department of General Internal Medicine, Tianjin Hospital, Tianjin, 300211, China.
authors.forename: Mei-Rong
authors.initials: MR
authors.lastname: Liu
authors.affiliation: Department of General Internal Medicine, Tianjin Hospital, Tianjin, 300211, China.
authors.forename: Shu-Xiang
authors.initials: SX
authors.lastname: Yang
authors.affiliation: Department of Radiotherapy, Zibo Central Hospital, Zibo, Shandong, 255020, China.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Dong
authors.affiliation: Department of General Internal Medicine, Tianjin Hospital, Tianjin, 300211, China.
authors.forename: Xiao-Feng
authors.identifier: http://orcid.org/0000-0001-7799-5147
authors.initials: XF
authors.lastname: Tan
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D000071681:Tartrate-Resistant Acid Phosphatase / Q000096:biosynthesis / Q000235:genetics*; D015854:Up-Regulation
chemical_list: D004273:DNA, Neoplasm; C000605510:ACP5 protein, human; D000071681:Tartrate-Resistant Acid Phosphatase
keywords: ACP5; biomarker; lung adenocarcinoma; prognosis; survival