title: Associations of specific psychiatric disorders with isolated focal dystonia, and monogenic and idiopathic Parkinson's disease.
abstract: Comorbidity of psychiatric disorders in patients with movement disorders is common. Often, psychiatric symptoms manifest before the onset of the movement disorder, thus not representing a mere reaction to its burden. How the disease mechanisms of psychiatric and movement disorders are related is still poorly understood. The aim of the present study was to compare prevalence rates of specific psychiatric disorders between different movement disorders including isolated focal dystonia (IFD, N = 91), monogenic Parkinson's disease (PD, N = 41), idiopathic PD (N = 45), and a sample from a Northern Germany general population (TACOS Study; N = 4075). Our results indicate an odds ratio (OR) of 2.6 [confidence interval (CI) 1.7-4.0] for general axis I disorders in IFD, an OR of 2.5 (CI 1.4-4.7) in monogenic PD, and an OR of 1.4 (CI 0.8-2.6) in idiopathic PD. More specifically, the monogenic PD group showed the highest ORs for affective disorders including depression (OR = 4.9), bipolar disorder (OR = 17.4), and hypomanic episodes (OR = 17.0), whereas IFD expressed the highest rates of anxiety disorders (OR = 3.3). Psychotic symptoms were only observed in the PD groups but not in IFD. Our findings underline the notion that psychiatric disorders are part of the phenotypic spectrum of movement disorders. Moreover, they suggest that IFD, monogenic PD, and idiopathic PD are associated with specific psychiatric disorders indicating disturbances in a different neural circuitry for sensorimotor control.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.|Helios Fachklinik Schleswig, Schleswig, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Steinlechner
authors.affiliation: Department of Neurology, Westküstenklinikum Heide, Heide, Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Hagenah
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Rumpf
authors.affiliation: Institute of Social Medicine and Prevention, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Meyer
authors.affiliation: Institute of Social Medicine and Prevention, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: John
authors.affiliation: Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.|Department of Neurology, University of Hamburg, Hamburg, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Bäumer
authors.affiliation: Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.|Department of Neurology, University of Lübeck, Lübeck, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Brüggemann
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.|Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
authors.forename: Meike
authors.initials: M
authors.lastname: Kasten
authors.affiliation: Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.|Department of Neurology, University of Hamburg, Hamburg, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Münchau
authors.affiliation: Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.affiliation: Department of Psychiatry and Psychotherapy and Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Albert-Schweitzer-Straße 11, 48149, Münster, Germany. rebekka.lencer@ukmuenster.de.
authors.forename: Rebekka
authors.initials: R
authors.lastname: Lencer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020821:Dystonic Disorders / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000145:classification / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000145:classification / Q000150:complications* / Q000453:epidemiology; D055815:Young Adult
keywords: Isolated focal dystonia; Movement disorders; Parkinson’s disease; Prevalence; Psychiatric disorders