title: The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.
abstract: The enzymology of 135 assembly lines containing primarily cis-acyltransferase modules is comprehensively analyzed, with greater attention paid to less common phenomena. Diverse online transformations, in which the substrate and/or product of the reaction is an acyl chain bound to an acyl carrier protein, are classified so that unusual reactions can be compared and underlying assembly-line logic can emerge. As a complement to the chemistry surrounding the loading, extension, and offloading of assembly lines that construct primarily polyketide products, structural aspects of the assembly-line machinery itself are considered. This review of assembly-line phenomena, covering the literature up to 2017, should thus be informative to the modular polyketide synthase novice and expert alike.
authors.affiliation: Department of Molecular Biosciences, The University of Texas at Austin , Austin, Texas 78712, United States.
authors.forename: Adrian T
authors.identifier: http://orcid.org/0000-0002-4358-7628
authors.initials: AT
authors.lastname: Keatinge-Clay
mesh_terms: D000217:Acyltransferases / Q000737:chemistry / Q000378:metabolism*; D048630:Polyketide Synthases / Q000378:metabolism; D061065:Polyketides / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D061065:Polyketides; D048630:Polyketide Synthases; D000217:Acyltransferases