title: Oxidation-Responsive, EuII/III-Based, Multimodal Contrast Agent for Magnetic Resonance and Photoacoustic Imaging.
abstract: We report, for the first time, a multimodal, oxidation-responsive contrast agent for magnetic resonance imaging and photoacoustic imaging that uses the differences in the properties between Eu in the +2 and +3 oxidation states. The enhancement of contrast inT1-weighted magnetic resonance and photoacoustic imaging was observed in the +2 but not in the +3 oxidation state, and the complex is a known chemical exchange saturation transfer agent for magnetic resonance imaging in the +3 oxidation state.
authors.affiliation: Department of Chemistry, Wayne State University , 5101 Cass Avenue, Detroit, Michigan 48202, United States.
authors.forename: Lina A
authors.initials: LA
authors.lastname: Basal
authors.affiliation: Department of Biomedical Engineering, Wayne State University , 818 W. Hancock, Detroit, Michigan 48201, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Radiology, Wayne State University , Detroit, Michigan 48201, United States.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Radiology, Wayne State University, Detroit, Michigan 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
authors.forename: E Mark
authors.initials: EM
authors.lastname: Haacke
authors.affiliation: Department of Biomedical Engineering, Wayne State University, 818 W. Hancock, Detroit, Michigan 48201, United States; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mehrmohammadi
authors.affiliation: Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, United States; Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Allen