title: Case Management of Dengue: Lessons Learned.
abstract: The global burden of dengue and its geographic distribution have increased over the past several decades. The introduction of dengue in new areas has often been accompanied by high case-fatality rates. Drawing on the experience in managing dengue cases at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, this article provides the authors' perspectives on key clinical lessons to improve dengue-related outcomes. Parallels between this clinical experience and outcomes reported in randomized controlled trials, results of efforts to disseminate practice recommendations, and suggestions for areas for further research are also discussed.
authors.affiliation: Dengue Unit, Queen Sirikit National Institute of Child Health, Bangkok, Thailand; and.
authors.forename: Siripen
authors.initials: S
authors.lastname: Kalayanarooj
authors.affiliation: Department of Cell and Molecular Biology and Institute for Immunology and Informatics, University of Rhode Island, Providence.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Rothman
authors.affiliation: Dengue Unit, Queen Sirikit National Institute of Child Health, Bangkok, Thailand ; and.|Department of Cell and Molecular Biology and Institute for Immunology and Informatics, University of Rhode Island, Providence.
authors.forename: Anon
authors.initials: A
authors.lastname: Srikiatkhachorn
mesh_terms: D015415:Biomarkers / Q000097:blood; D019090:Case Management; D002648:Child; D003715:Dengue / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D042241:Early Diagnosis; D005440:Fluid Therapy; D006801:Humans; D013785:Thailand / Q000453:epidemiology
chemical_list: D015415:Biomarkers
keywords: case management; case-fatality rate.; clinical care; dengue; hemorrhage; plasma leakage