title: MicroRNA-137 inhibits growth of glioblastoma through EGFR suppression.
abstract: Aberrant expression of certain microRNAs (miRNAs) has been shown to contribute to the development of Glioblastoma multiforme (GBM). However, the involvement of miR-137 in the carcinogenesis of GBM has not been reported. Here, we showed that miR-137 levels in GBM tissues were significantly lower than the paired normal brain tissue in patients' specimens. Moreover, low miR-137 levels in GBM tissue were associated with poor prognosis. In vitro, overexpression of miR-137 decreased GBM cell growth and increased cell apoptosis, while depletion of miR-137 enhanced cell growth and decreased cell apoptosis. Combined bioinformatics analysis and dual luciferase reporter assay showed that miR-137 may target the 3'-UTR of the epidermal growth factor receptor (EGFR) to reduce its protein translation, resulting in suppression of EGFR signaling in GBM cells. Together, our data suggest that reduction in miR-137 levels in GBM tissues may increase cell growth and decrease cell apoptosis, possibly through suppression of EGFR.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China.
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Histology and Embryology, Jinzhou Medical University Jinzhou 121001, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Histology and Embryology, Jinzhou Medical University Jinzhou 121001, China.
authors.forename: He
authors.initials: H
authors.lastname: Tian
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Miao
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China.
authors.forename: Honglei
authors.initials: H
authors.lastname: Wang
keywords: Glioblastoma multiforme (GBM); epidermal growth factor receptor (EGFR); miR-137