title: [New biomaterials and alternative stem cell sources for the reconstruction of the limbal stem cell niche].
abstract: Reconstruction of the limbal stem cell niche in patients with limbal stem cell insufficiency remains one of the most challenging tasks in the treatment of ocular surface diseases. Ex vivo expansion of limbal stem cells still has potential for optimization despite positive reports in centers worldwide. New biomaterials as well as alternative cell sources for the reconstruction of the limbal stem cell niche have been published in recent years. The aim of this review is to provide insight into new biomaterials and cell sources which may find their way into clinical routine in the upcoming decades.
authors.affiliation: Klinik für Augenheilkunde, Uniklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland. philipp.eberwein@uniklinik-freiburg.de.
authors.forename: P
authors.initials: P
authors.lastname: Eberwein
authors.affiliation: Klinik für Augenheilkunde, Uniklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Reinhard
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000473:pathology* / Q000628:therapy*; D016039:Corneal Transplantation / Q000379:methods; D004847:Epithelial Cells / Q000166:cytology / Q000637:transplantation; D019573:Epithelium, Corneal / Q000473:pathology / Q000637:transplantation; D019317:Evidence-Based Medicine; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology*; D059351:Organ Sparing Treatments / Q000379:methods; D055153:Stem Cell Niche; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D020858:Tissue and Organ Harvesting / Q000379:methods; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials
keywords: Complications; Limbal stem cell insufficiency; Ocular surface; Safety; Tissue engineering