title: Animal models for percutaneous-device-related infections: a review.
abstract: This review focuses on the construction of animal models for percutaneous-device-related infections, and specifically the role of inoculation of bacteria in such models. Infections around percutaneous devices, such as catheters, dental implants and limb prostheses, are a recurrent and persistent clinical problem. To promote the research on this clinical problem, the establishment of a reliable and validated animal model would be of keen interest. In this review, literature related to percutaneous devices was evaluated, and particular attention was paid to studies involving the use of bacteria. The design of percutaneous devices, susceptibility of various animal species, bacterial strains, amounts of bacteria, method of inoculation and methods for subsequent evaluation of the infection are discussed in detail. Given that an ideal animal model for study of percutaneous-device-related infection is still not existent, this article presents the basis for the construction of such a standardized animal model for percutaneous-device-related infection studies. The inoculation of bacteria is critical to obtain an animal model for standardized studies for percutaneous-device-related infections.
authors.affiliation: Department of Biomaterials, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Jinlong
authors.initials: J
authors.lastname: Shao
authors.affiliation: Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Eva
authors.initials: E
authors.lastname: Kolwijck
authors.affiliation: Department of Biomaterials, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
authors.affiliation: Department of Biomaterials, Radboud University Medical Centre, Nijmegen, The Netherlands.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Biomaterials, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: frank.walboomers@radboudumc.nl.
authors.forename: X Frank
authors.initials: XF
authors.lastname: Walboomers
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology* / Q000473:pathology*; D023421:Models, Animal; D016459:Prosthesis-Related Infections / Q000382:microbiology* / Q000473:pathology*
keywords: Animal models; Implants; Prostheses; Prosthesis-related infections