title: Comparison of the effects of denosumab with either active vitamin D or native vitamin D on bone mineral density and bone turnover markers in postmenopausal osteoporosis.
abstract: Osteoporosis is a worldwide health concern. Although treatment with denosumab plus the active vitamin D alfacalcidol has been found to improve femoral neck (FN) and distal forearm bone mineral density (BMD), there have been no reports on the efficacy or adverse effects of denosumab plus eldecalcitol (ELD) in primary osteoporosis patients. Fifty-six treatment-naïve post-menopausal women with primary osteoporosis were recruited and divided into denosumab plus native vitamin D or denosumab plus ELD. Ultimately, 26 subjects in the native vitamin D group and 24 in the ELD group were analyzed. Lumbar and total hip BMD significantly increased in both groups. However, there was no significant difference in the percent increase of lumbar and total hip BMD between two groups. FN-BMD was significantly increased from 6 to 12 months in the ELD group compared with baseline. This study revealed that combination therapy with denosumab and ELD could improve FN-BMD more effectively than denosumab plus native vitamin D. Thus, the addition of ELD may enhance the effects of denosumab treatment for primary osteoporosis.
authors.affiliation: a Department of Orthopaedic Surgery , Shinshu University School of Medicine , Matsumoto, Nagano , Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: a Department of Orthopaedic Surgery , Shinshu University School of Medicine , Matsumoto, Nagano , Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: b Department of Orthopedic Surgery , Kawakita General Hospital , Tokyo , Japan.
authors.forename: Mizue
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: c Center of Osteoporosis and Spinal Disorders , Kamimura Orthopaedic Clinic , Matsumoto, Nagano , Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Kamimura
authors.affiliation: a Department of Orthopaedic Surgery , Shinshu University School of Medicine , Matsumoto, Nagano , Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Ikegami
authors.affiliation: a Department of Orthopaedic Surgery , Shinshu University School of Medicine , Matsumoto, Nagano , Japan.
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Uchiyama
authors.affiliation: a Department of Orthopaedic Surgery , Shinshu University School of Medicine , Matsumoto, Nagano , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
mesh_terms: D000368:Aged; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000069448:Denosumab / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D014815:Vitamins; D014807:Vitamin D; D000069448:Denosumab; C547512:eldecalcitol
keywords: Bone mineral density; bone turnover markers; denosumab; osteoporosis; vitamin D