title: BiteStrip analysis of the effect of fluoxetine and paroxetine on sleep bruxism.
abstract: OBJECTIVE
  The relationship between sleep bruxism (SB) and selective serotonin reuptake inhibitors (SSRIs) is still under debate because of the lack of well-designed objective studies. The current study investigates possible effects of SSRIs, fluoxetine, and paroxetine on SB in patients with anxiety and depression.
  
  
  METHODS
  Thirty users of SSRIs for treatment of depression or anxiety were enrolled in the study. After clinical and anamnestic examination, 15 fluoxetine and 15 paroxetine users were included. For an objective evaluation of SB, a single-use disposable home screening device, BiteStrip, was used prior to the first SSRI intake and was repeated on the 7th and 15th days. Patients' self-reported data also were obtained for assessment of patient awareness.
  
  
  RESULTS
  BiteStrip scores were significantly higher on the 7th and 15th days than the first measurement (p<0.01). There was an increase in 26 (86.6%) patients' bruxism scores on the 7th day. There was also an increase in 27 (90%) patients' bruxism scores on the 15th day. But according to patients' self-reports, only 6 patients had an awareness that bruxism symptoms were initiated or exacerbated 15days after starting fluoxetine or paroxetine.
  
  
  CONCLUSIONS
  Fluoxetine and paroxetine, SSRIs used for the treatment of anxiety and depression, may initiate or aggravate SB. Clinicians should consider that SSRIs may be the cause of SB when SSRI users are referred to dental clinics for SB symptoms. As there is a shortage of researches on this subject, further studies are necessary to confirm the existence of SSRI-induced SB.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Çelebi University, Izmir, Turkey. Electronic address: phismer@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Isa Kara
authors.affiliation: Dept. of Oral and Maxillofacial Radiology, Faculty of Dentistry, Izmir Katip Çelebi University, Izmir, Turkey.
authors.forename: Elif Tarım
authors.initials: ET
authors.lastname: Ertaş
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Çelebi University, Izmir, Turkey.
authors.forename: Emrullah
authors.initials: E
authors.lastname: Ozen
authors.affiliation: Dept. of Oral and Maxillofacial Radiology, Faculty of Dentistry, Izmir Katip Çelebi University, Izmir, Turkey.
authors.forename: Meral
authors.initials: M
authors.lastname: Atıcı
authors.affiliation: Department of Psychiatry, Karsıyaka Government Hospital, Izmir, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Aksoy
authors.affiliation: Dept. of Orthodontics, Faculty of Dentistry, Izmir Katip Çelebi University, Izmir, Turkey.
authors.forename: Muharrem Serif
authors.initials: MS
authors.lastname: Erdogan
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Faculty of Dentistry, Izmir Katip Çelebi University, Izmir, Turkey.
authors.forename: Seyfi
authors.initials: S
authors.lastname: Kelebek
mesh_terms: D000328:Adult; D001007:Anxiety / Q000188:drug therapy; D003742:Dental Devices, Home Care; D003863:Depression / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000009:adverse effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D020186:Sleep Bruxism / Q000139:chemically induced*; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: BiteStrip; Fluoxetine; Paroxetine; Selective serotonin reuptake inhibitor (SSRI); Sleep bruxism