title: Fluorescent polymer prodrug nanoparticles with aggregation-induced emission (AIE) properties from nitroxide-mediated polymerization.
abstract: Aggregation-induced emission (AIE)-active polymer prodrug nanoparticles were readily prepared by growing short, well-defined polymer chains from an AIE dye by nitroxide-mediated polymerization, followed by co-nanoprecipitation of the resulting conjugates with similarly constructed anticancer polymer prodrugs. The nanoparticles had sharp fluorescence signal offering excellent imaging ability in living cells and their intra cellular localization to be accurately monitored.
authors.affiliation: Institut Galien Paris-Sud, Université Paris-Sud, UMR CNRS 8612, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry cedex, France. julien.nicolas@u-psud.fr.
authors.forename: Yinyin
authors.initials: Y
authors.lastname: Bao
authors.forename: Elise
authors.initials: E
authors.lastname: Guégain
authors.forename: Valérie
authors.initials: V
authors.lastname: Nicolas
authors.forename: Julien
authors.initials: J
authors.lastname: Nicolas
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D005453:Fluorescence; D006801:Humans; D008247:Lysosomes / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D009589:Nitrogen Oxides / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009589:Nitrogen Oxides; D011108:Polymers; D011355:Prodrugs