title: A Naturalistic Study of Driving Behavior in Older Adults and Preclinical Alzheimer Disease: A Pilot Study.
abstract: A clinical consequence of symptomatic Alzheimer's disease (AD) is impaired driving performance. However, decline in driving performance may begin in the preclinical stage of AD. We used a naturalistic driving methodology to examine differences in driving behavior over one year in a small sample of cognitively normal older adults with ( n = 10) and without ( n = 10) preclinical AD. As expected with a small sample size, there were no statistically significant differences between the two groups, but older adults with preclinical AD drove less often, were less likely to drive at night, and had fewer aggressive behaviors such as hard braking, speeding, and sudden acceleration. The sample size required to power a larger study to determine differences was calculated.
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: Ganesh M
authors.initials: GM
authors.lastname: Babulal
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Stout
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: Tammie L S
authors.initials: TLS
authors.lastname: Benzinger
authors.affiliation: 2 Brown University, Providence, RI, USA.
authors.forename: Brian R
authors.initials: BR
authors.lastname: Ott
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Carr
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: Mollie
authors.initials: M
authors.lastname: Webb
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: Cindy M
authors.initials: CM
authors.lastname: Traub
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Addison
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: David K
authors.initials: DK
authors.lastname: Warren
authors.affiliation: 1 Washington University in St. Louis, MO, USA.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Roe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D001334:Automobile Driving / Q000523:psychology* / Q000706:statistics & numerical data*; D003625:Data Collection / Q000295:instrumentation / Q000379:methods; D005260:Female; D006184:Habits; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008923:Missouri; D010865:Pilot Projects; D012449:Safety
keywords: Alzheimer’s disease; driving; naturalistic methodology; older adults