title: Propofol-induced acute pancreatitis.
abstract: OBJECTIVE
  Drug-induced acute pancreatitis comprises only 0.5%-2% of all cases of acute pancreatitis. Propofol is a potentially dangerous drug that can cause acute pancreatitis, but this complication is extremely rare.
  
  
  METHODS
  A 57-year-old patient developed acute pancreatitis after a planned thyroidectomy. As the common causes of acute pancreatitis were excluded, we believe that the pancreatitis was drug-induced, in this case by a single dose of propofol administered to the patient during the surgery.
  
  
  CONCLUSIONS
  We present a rare case of propofol-induced acute necrotising pancreatitis, which is to the best of our knowledge the first fatal case reported in an adult patient.
authors.affiliation: Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Csomor
authors.affiliation: Department of Clinical Pharmacy, Military University Hospital Prague, Prague, Czech Republic.|Department of Applied Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
authors.forename: I
authors.initials: I
authors.lastname: Murínová
authors.affiliation: Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, Prague, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Broulíková
authors.affiliation: Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, Prague, Czech Republic.
authors.forename: O
authors.initials: O
authors.lastname: Kučerka
authors.affiliation: Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Sedloň
authors.affiliation: Surgical Clinic, 2nd Faculty of Medicine, Charles University and Military University Hospital Prague, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Jarošek
authors.affiliation: Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Urbánek
authors.affiliation: Department of Internal Medicine, 1st Medical Faculty Charles University and Central Military Hospital Prague, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Zavoral
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced*; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D013965:Thyroidectomy / Q000379:methods
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol
keywords: adverse drug reaction; drug-induced acute pancreatitis; propofol