title: Oleic acid-derived oleoylethanolamide: A nutritional science perspective.
abstract: The fatty acid ethanolamide oleoylethanolamide (OEA) is an endogenous lipid mediator derived from the monounsaturated fatty acid, oleic acid. OEA is synthesized from membrane glycerophospholipids and is a high-affinity agonist of the nuclear transcription factor peroxisome proliferator-activated receptor α (PPAR-α). Dietary intake of oleic acid elevates circulating levels of OEA in humans by increasing substrate availability for OEA biosynthesis. Numerous clinical studies demonstrate a beneficial relationship between high-oleic acid diets and body composition, with emerging evidence to suggest OEA may mediate this response through modulation of lipid metabolism and energy intake. OEA exposure has been shown to stimulate fatty acid uptake, lipolysis, and β-oxidation, and also promote food intake control. Future research on high-oleic acid diets and body composition is warranted to confirm these outcomes and elucidate the underlying mechanisms by which oleic acid exerts its biological effects. These findings have significant practical implications, as the oleic acid-derived OEA molecule may be a promising therapeutic agent for weight management and obesity treatment.
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA 16802, USA.
authors.forename: Kate J
authors.initials: KJ
authors.lastname: Bowen
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA 16802, USA.
authors.forename: Penny M
authors.initials: PM
authors.lastname: Kris-Etherton
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA 16802, USA.
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Shearer
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA 16802, USA; Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, USA.
authors.forename: Sheila G
authors.initials: SG
authors.lastname: West
authors.affiliation: Department of Plant Science, The Pennsylvania State University, 102 Tyson Building, University Park, PA 16802, USA.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Reddivari
authors.affiliation: Richardson Center for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg, MB R3T 6C5, Canada. Electronic address: Peter.Jones@umanitoba.ca.
authors.forename: Peter J H
authors.initials: PJH
authors.lastname: Jones
mesh_terms: D000818:Animals; D001823:Body Composition / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology; D063388:Endocannabinoids / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D052756:Nutritional Sciences; D009829:Oleic Acids / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D004041:Dietary Fats; D063388:Endocannabinoids; D009829:Oleic Acids; D011956:Receptors, Cell Surface; C488250:oleoylethanolamide
keywords: Body composition; Dietary fat; Lipid metabolism; N-acylethanolamine; Oleic acid; Oleoylethanolamide