title: One-Step Transformation of Coenzyme A into Analogues by Transamidation.
abstract: Several coenzyme A (CoA) analogues are made in a single step under mild conditions via transamidation reactions catalyzed by boric acid in water. This approach offers rapid access to compounds useful for the study of a wide spectrum of enzyme catalyzed reactions, especially processes involving acyl carrier proteins (ACP) of polyketide synthases (PKS), fatty acid synthases (FAS), and nonribosomal peptide synthetases (NRPS). The CoA analogues presented are readily elaborated or extended by precedented reactions for specific applications that may be required.
authors.affiliation: Department of Chemistry, University of Alberta , Edmonton, Alberta, Canada T6G 2G2.
authors.forename: Randy
authors.initials: R
authors.lastname: Sanichar
authors.affiliation: Department of Chemistry, University of Alberta , Edmonton, Alberta, Canada T6G 2G2.
authors.forename: John C
authors.identifier: 0000-0002-2996-0326
authors.initials: JC
authors.lastname: Vederas
mesh_terms: D000213:Acyl Carrier Protein / Q000737:chemistry; D001888:Boric Acids / Q000737:chemistry*; D002384:Catalysis; D003065:Coenzyme A / Q000737:chemistry*; D003543:Cysteamine / Q000737:chemistry; D064429:Fatty Acid Synthases / Q000737:chemistry; D015394:Molecular Structure; D010453:Peptide Synthases / Q000737:chemistry; D048630:Polyketide Synthases / Q000737:chemistry; D013696:Temperature; D013995:Time; D014867:Water
chemical_list: D000213:Acyl Carrier Protein; D001888:Boric Acids; D014867:Water; D003543:Cysteamine; D048630:Polyketide Synthases; D064429:Fatty Acid Synthases; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase; C032688:boric acid; D003065:Coenzyme A