title: From dysfunctional endoplasmic reticulum-mitochondria coupling to neurodegeneration.
abstract: Over the last years, contact sites between the endoplasmic reticulum (ER) and mitochondria have attracted great attention in the study of cell homeostasis and dysfunction, especially in the context of neurodegenerative disorders. This is largely due to the critical involvement of this subcellular compartment in a plethora of vital cellular functions: Ca2+homeostasis, mitochondrial dynamics, transport, bioenergetics and turnover, ER stress, apoptotic signaling and inflammation. An increasing number of disease-associated proteins have been reported to physically associate with the ER-mitochondria interface, and cause structural and/or functional perturbations of this compartment. In the present review, we summarize current knowledge about the architecture and functions of the ER-mitochondria contact sites, and the consequences of their alteration in different neurodegenerative disorders. Special emphasis is placed on the caveats and difficulties in defining the nature and origin of the highlighted defects in ER-mitochondria communication, and their exact contribution to the neurodegenerative process.
authors.affiliation: Inserm, U1127, F-75013, Paris, France; CNRS, UMR 7225, F-75013, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France.
authors.forename: Zoi
authors.initials: Z
authors.lastname: Erpapazoglou
authors.affiliation: Inserm, U1127, F-75013, Paris, France; CNRS, UMR 7225, F-75013, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Mouton-Liger
authors.affiliation: Inserm, U1127, F-75013, Paris, France; CNRS, UMR 7225, F-75013, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, F-75013, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France. Electronic address: olga.corti@upmc.fr.
authors.forename: Olga
authors.initials: O
authors.lastname: Corti
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000473:pathology; D059865:Endoplasmic Reticulum Stress / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D063154:Mitochondrial Dynamics / Q000502:physiology; D051336:Mitochondrial Membranes / Q000378:metabolism* / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology
keywords: Alzheimer's disease; Amyotrophic lateral sclerosis; Calcium and lipid metabolism; ER-mitochondria contacts; Inflammation; Neurodegeneration; Parkinson's disease