title: Prevalence of Cryptosporidium Carriage and Disease in Children With Primary Immune Deficiencies Undergoing Hematopoietic Stem Cell Transplant in Northern Europe.
abstract: A prospective cohort study of children with primary immunodeficiencies undergoing hematopoietic stem cell transplant in the United Kingdom investigated the extent and significance of Cryptosporidium carriage in this high risk group. Three of 42 children recruited were infected with Cryptosporidium, a lower proportion than previously described. One had serious disease. The underlying immunodeficiency likely had a bearing on the clinical presentation and possible outcome of infection.
authors.affiliation: From the *Swansea University Medical School, Singleton Park, Swansea, United Kingdom; †Cryptosporidium Reference Unit, Public Health Wales Microbiology Swansea, Singleton Hospital, Sketty Lane, Swansea, United Kingdom; ‡Paediatric Immunology Department, Great North Children's Hospital, Queen Victoria Road, Newcastle upon Tyne, United Kingdom; §Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; and ¶Centre for Immunodeficiency, Institute of Child Health, University College London and Great Ormond Street Hospital, London, United Kingdom.
authors.forename: Angharad P
authors.initials: AP
authors.lastname: Davies
authors.forename: Mary
authors.initials: M
authors.lastname: Slatter
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Gennery
authors.forename: Guy
authors.initials: G
authors.lastname: Robinson
authors.forename: Nigel
authors.initials: N
authors.lastname: Crouch
authors.forename: Kristin
authors.initials: K
authors.lastname: Elwin
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Hadfield
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Cant
authors.forename: E Graham
authors.initials: EG
authors.lastname: Davies
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Chalmers
mesh_terms: D002648:Child; D002675:Child, Preschool; D003457:Cryptosporidiosis / Q000453:epidemiology* / Q000276:immunology / Q000469:parasitology / Q000628:therapy; D003458:Cryptosporidium / Q000254:growth & development / Q000302:isolation & purification*; D005060:Europe / Q000453:epidemiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000453:epidemiology* / Q000276:immunology / Q000469:parasitology / Q000628:therapy; D007223:Infant; D008297:Male; D015995:Prevalence; D011446:Prospective Studies