title: Comparison of the clinical parameters of benign prostate hyperplasia in diabetic and non diabetic patients.
abstract: OBJECTIVE
  We evaluated the correlation between benign prostate hyperplasia (BPH) measures and diabetes mellitus in men with benign prostate hyperplasia in a prospective study.
  
  
  METHODS
  Between 2008-2012, 100 diabetic and 200 non diabetic patients undergoing surgery due to benign prostate hyperplasia were enrolled in the study. The parameters evaluated for each patients included prostate volume, fasting blood glucose, HbA1c, total testosterone, total prostatic specific antigen (T-PSA), triglicerides, total cholesterol and body mass index (BMI). A questionnaire including international prostate symptom score (IPSS) was sdministered and uroflow test measuring the peak urinary flow rate was performed to appreciate the complaints of the patients objectively.
  
  
  RESULTS
  Diabetic patients are more likely to have larger prostate volume. The symptom score evaluated by IPSS and post micturition residual volume were also significantly higher in diabetic groups. The other statistically significant different parameter between two groups was total testosterone that diabetic patients tend to have lower levels. Diabetic counterparts were established to have higher BMI. No statistically significant differentiation was observed about trigliceryde and total cholesterol levels and uroflow rates.
  
  
  CONCLUSIONS
  Our study suggests a positive correlation between high prostate volume and diagnosis of diabetes mellitus in patients with benign prostatic hyperplasia. We also observed a positive correlation between symptom scores and post micturion residual volumes and diagnosis of diabetes mellitus suggesting that the presence of diabetes is related to both static and dynamic components of benign prostate hyperplasia. Additionally testosterone levels were lower in diabetic patients. Further studies need to confirm these relationship in a larger population.
authors.affiliation: Department of Urology, Derince Training and Research Hospital, Kocaeli. drleventozcan@yahoo.com.
authors.forename: Levent
authors.initials: L
authors.lastname: Ozcan
authors.forename: Huseyin
authors.initials: H
authors.lastname: Besiroglu
authors.forename: Murat
authors.initials: M
authors.lastname: Dursun
authors.forename: Emre Can
authors.initials: EC
authors.lastname: Polat
authors.forename: Alper
authors.initials: A
authors.lastname: Otunctemur
authors.forename: Emin
authors.initials: E
authors.lastname: Ozbek
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000473:pathology*; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood; D014280:Triglycerides / Q000097:blood*; D014554:Urination / Q000502:physiology
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D013739:Testosterone; D002784:Cholesterol; D017430:Prostate-Specific Antigen