title: Synovial Sarcoma: Advances in Diagnosis and Treatment Identification of New Biologic Targets to Improve Multimodal Therapy.
abstract: Synovial sarcoma is a translocation-associated soft-tissue malignancy that frequently affects adolescents and young adults. It is driven by one of the fusion oncoproteins SS18-SSX1, SS18-SSX2, or rarely, SS18-SSX4. Prognosis of patients with recurrent or metastatic disease is generally poor, and newer therapeutic strategies are needed. In this review, we present recent discoveries in the pathogenesis, diagnosis, and treatment of synovial sarcoma. We discuss potential therapeutic strategies to improve clinical outcomes in this disease.
authors.affiliation: Department of Orthopaedic Oncology - Unit 1448, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: El Beaino
authors.affiliation: Department of Sarcoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Dejka M
authors.initials: DM
authors.lastname: Araujo
authors.affiliation: Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Lazar
authors.affiliation: Department of Orthopaedic Oncology - Unit 1448, MD Anderson Cancer Center, Houston, TX, USA. plin@mdanderson.org.
authors.forename: Patrick P
authors.initials: PP
authors.lastname: Lin
mesh_terms: D001688:Biological Products / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D058990:Molecular Targeted Therapy; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D001688:Biological Products