title: Can We Just Say: Transcription Second?
abstract: The striking correlation between genome topology and transcriptional activity has for decades made researchers revisit the question, "Does form follow function, or does function follow form?" In a new study, Hug et al. address this question by comparing the timing of zygotic genome activation to the emergence of genome structures during Drosophila embryogenesis.
authors.affiliation: Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.
authors.forename: Peter Hugo Lodewijk
authors.initials: PHL
authors.lastname: Krijger
authors.affiliation: Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands. Electronic address: w.delaat@hubrecht.eu.
authors.forename: Wouter
authors.initials: W
authors.lastname: de Laat
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D016678:Genome; D015053:Zygote