title: Effect of alcohol after muscle-damaging resistance exercise on muscular performance recovery and inflammatory capacity in women.
abstract: OBJECTIVE
  To investigate the effect of acute alcohol consumption on muscular performance recovery, assessed by maximal torque production, and on inflammatory capacity, assessed by lipopolysaccharide (LPS)-stimulated cytokine production, following muscle-damaging resistance exercise in women.
  
  
  METHODS
  Thirteen recreationally resistance-trained women completed two identical exercise bouts (300 maximal single-leg eccentric leg extensions) followed by alcohol (1.09 g ethanol kg-1fat-free body mass) or placebo ingestion. Blood was collected before (PRE), and 5 (5 h-POST), 24 (24 h-POST), and 48 (48 h-POST) hours after exercise and analyzed for LPS-stimulated cytokine production (TNF-α, IL-1β, IL-6, and IL-8 and IL-10). Maximal torque production (concentric, eccentric, isometric) was measured for each leg at PRE, 24 h-POST, and 48 h-POST.
  
  
  RESULTS
  Although the exercise bout increased LPS-stimulated production of TNF-α (%change from PRE: 5 h-POST 109%; 24 h-POST 49%; 48 h-POST 40%) and decreased LPS-stimulated production of IL-8 (5 h-POST -40%; 24 h-POST -50%; 48 h-POST: -43%) and IL-10 (5 h-POST: -37%; 24 h-POST -32%; 48 h-POST -31%), consuming alcohol after exercise did not affect this response. Regardless of drink condition, concentric, eccentric, and isometric torque produced by the exercised leg were lower at 24 h-POST (concentric 106 ± 6 Nm, eccentric 144 ± 9 Nm, isometric 128 ± 8 Nm; M ± SE) compared to PRE (concentric 127 ± 7 Nm, eccentric 175 ± 11 Nm, isometric 148 ± 8 Nm). Eccentric torque production was partially recovered and isometric torque production was fully recovered by 48 h-POST.
  
  
  CONCLUSIONS
  Alcohol consumed after muscle-damaging resistance exercise does not appear to affect inflammatory capacity or muscular performance recovery in resistance-trained women. Combined with previous findings in men, these results suggest a gender difference regarding effects of alcohol on exercise recovery.
authors.affiliation: Applied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203, USA.|Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX, 76203, USA.
authors.forename: Danielle E
authors.initials: DE
authors.lastname: Levitt
authors.affiliation: Applied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203, USA.|Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX, 76203, USA.
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Luk
authors.affiliation: Department of Physiology, Louisiana State University Health Sciences Center School of Medicine, 1901 Perdido St., New Orleans, LA, 70112, USA.
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Duplanty
authors.affiliation: Applied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203, USA.|Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX, 76203, USA.
authors.forename: Brian K
authors.initials: BK
authors.lastname: McFarlin
authors.affiliation: Applied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Hill
authors.affiliation: Applied Physiology Laboratory, Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, 1155 Union Circle #310769, Denton, TX, 76203, USA. Jakob.Vingren@unt.edu.|Department of Biological Sciences, University of North Texas, 1155 Union Circle #305220, Denton, TX, 76203, USA. Jakob.Vingren@unt.edu.
authors.forename: Jakob L
authors.initials: JL
authors.lastname: Vingren
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D016207:Cytokines / Q000097:blood*; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D063806:Myalgia / Q000150:complications / Q000209:etiology*; D055070:Resistance Training / Q000009:adverse effects*; D012737:Sex Factors
chemical_list: D016207:Cytokines; D000431:Ethanol
keywords: Binge drinking; Cytokines; Lipopolysaccharide; Muscle damage; Resistance exercise