title: The Dynamics of Cardiovascular Biomarkers in non-Elite Marathon Runners.
abstract: The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples were collected at baseline (24-48 h before the race), immediately after the race (1-2 h after the race), and 48-h post-race. Amino-terminal pro-B type natriuretic peptide (NT-proBNP, a marker of myocardial strain), ST2 (a marker of extracellular matrix remodeling and fibrosis, inflammation, and myocardial strain), and high-sensitivity troponin T (hs-TnT, a marker of myocyte stress/injury) were assayed. The median (interquartile range, IQR) years of training was 7 (5-11) years and median (IQR) weekly training hours was 6 (5-8) h/week, respectively. The median (IQR) race time (h:min:s) was 3:32:44 (3:18:50-3:51:46). Echocardiographic indices were within normal ranges. Immediately after the race, blood concentration of the three cardiac biomarkers increased significantly, with 1.3-, 1.6-, and 16-fold increases in NT-proBNP, ST2, and hs-TnT, respectively. We found an inverse relationship between weekly training hours and increased ST2 (p = 0.007), and a direct relationship between race time and increased hs-TnT (p < 0.001) and ST2 (p = 0.05). Our findings indicate that preparation for and participation in marathon running may affect multiple pathways affecting the cardiovascular system. More data and long-term follow-up studies in non-elite and elite athletes are needed.
authors.affiliation: Universitat Politècnica de Catalunya, Barcelona, Spain.
authors.forename: Emma
authors.initials: E
authors.lastname: Roca
authors.affiliation: Universitat Politècnica de Catalunya, Barcelona, Spain.
authors.forename: Lexa
authors.initials: L
authors.lastname: Nescolarde
authors.affiliation: Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n 08916 Badalona, Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Lupón
authors.affiliation: Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n 08916 Badalona, Barcelona, Spain.|Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Barallat
authors.affiliation: Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
authors.affiliation: University of Ottawa Heart Institute, Ottawa, ON, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Liu
authors.affiliation: Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n 08916 Badalona, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Cruz Pastor
authors.affiliation: Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n 08916 Badalona, Barcelona, Spain. abayesgenis@gmail.com.|Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. abayesgenis@gmail.com.|CIBERCV, Madrid, Spain. abayesgenis@gmail.com.
authors.forename: Antoni
authors.initials: A
authors.lastname: Bayes-Genis
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D015415:Biomarkers / Q000097:blood; D059267:Cardiomegaly, Exercise-Induced; D002319:Cardiovascular System / Q000378:metabolism*; D004452:Echocardiography; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010807:Physical Endurance; D012420:Running; D013997:Time Factors; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Biomarkers; Hs-TnT; Marathon; NT-proBNP; ST2; Sports