title: Celiac disease prevalence in a large series of patients with Behçet's disease.
abstract: OBJECTIVE
  There are common findings between Behçet's disease (BD) and celiac disease (CD) based on similar immunological pathogenesis and there is only limited data available investigating the link between these two diseases. Furthermore, documented gastrointestinal (GI) involvement with marked upper GI symptoms in BD has been rarely reported. The aim of this study was to assess the prevalence of CD and to evaluate endoscopic findings in Turkish BD patients.
  
  
  METHODS
  A total of 210 BD patients were included in the study. All patients underwent serological testing for anti-gliadin and tissue transglutaminase antibodies. Endoscopic examinations were performed in 190 patients who accepted upper GI system endoscopy. Multiple biopsies were taken from the second portion of the duodenum in patients with positive serological assessment for CD.
  
  
  RESULTS
  A total of 4.2% of patients with BD had positive anti-gliadin and tissue transglutaminase antibody immunoglobulin A (IgA) and IgG antibodies. The prevalence of biopsy-confirmed CD was 1.05% in Turkish BD patients. The most common endoscopic findings of patients with BD were found to be antral gastritis, duodenitis and esophagitis.
  
  
  CONCLUSIONS
  Although BD and CD share many similar clinical manifestations, our results did not support a possible association between these two diseases.
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, İstanbul Bilim University, İstanbul, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Koçak
authors.affiliation: Department of Gastroenterology, Faculty of Medicine, İstanbul Bilim University, İstanbul, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Akbal
authors.affiliation: Department of Gastroenterology, Çanakkale State Hospital, Çanakkale, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Beyazit
authors.affiliation: Department of Gastroenterology, Kırşehir State Hospital, Kırşehir, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Ergül
authors.affiliation: Department of Dermatology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Karataş
authors.affiliation: Department of Gastroenterology, Hacettepe University Hospital, Ankara, Turkey.
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Köklü
authors.affiliation: Department of Dermatology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: H Meral
authors.initials: HM
authors.lastname: Ekşioğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D001528:Behcet Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D002648:Child; D004382:Duodenitis / Q000453:epidemiology; D004386:Duodenum / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D004941:Esophagitis / Q000453:epidemiology; D005260:Female; D019204:GTP-Binding Proteins / Q000276:immunology; D005756:Gastritis / Q000453:epidemiology; D005903:Gliadin / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D012698:Serologic Tests; D011503:Transglutaminases / Q000276:immunology; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D005903:Gliadin; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins
keywords: Behçet's disease; celiac disease; prevalence; upper gastrointestinal endoscopy