title: Potential mechanisms of Zika-linked microcephaly.
abstract: A recent outbreak of Zika virus (ZIKV) in Brazil is associated with microcephaly in infants born of infected mothers. As this pandemic spreads, rapid scientific investigation is shedding new light on how prenatal infection with ZIKV causes microcephaly. In this analysis we provide an overview of both microcephaly and ZIKV, explore the connection between prenatal ZIKV infection and microcephaly, and highlight recent insights into how prenatal ZIKV infection depletes the pool of neural progenitors in the developing brain. WIREs Dev Biol 2017, 6:e273. doi: 10.1002/wdev.273 For further resources related to this article, please visit the WIREs website.
authors.affiliation: Biology Department, Reed College, Portland, OR, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Merfeld
authors.affiliation: Biology Department, Reed College, Portland, OR, USA.
authors.forename: Lily
authors.initials: L
authors.lastname: Ben-Avi
authors.affiliation: Biology Department, Reed College, Portland, OR, USA.
authors.forename: Mason
authors.initials: M
authors.lastname: Kennon
authors.affiliation: Biology Department, Reed College, Portland, OR, USA.
authors.forename: Kara L
authors.identifier: 0000-0003-0667-827X
authors.initials: KL
authors.lastname: Cerveny
mesh_terms: D000818:Animals; D006801:Humans; D008831:Microcephaly / Q000209:etiology* / Q000473:pathology; D000071244:Zika Virus / Q000472:pathogenicity*; D000071243:Zika Virus Infection / Q000150:complications*