title: miRNA-370 acts as a tumor suppressor via the downregulation of PIM1 in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is a primary malignancy of liver. Nowadays HCC is one of the most common and aggressive malignancies worldwide. This study shows the aberrant up-regulation or down-regulation of miR-370correlates with the development and prognosis of different human malignancies including HCC.
  
  
  
  The HCC cell lines were used as model cell lines and the anti-tumor effect of miR-370 in vitro were examined. The level of miR-370 in HCC cells was determined by qRT-PCR and restored in GC cells by using miR-370 mimic. Moreover, the target gene of miR-370 was then identified.
  
  
  
  The expression of miR-370 in HCC cell lines was significantly lower than that in the other human liver cells. The miR-370 acted as a tumor suppressor in HCC. Moreover, it showed that miR-370 exerted anti-tumor effect by targeting PIM1 directly, a serine/threonine-specific kinase involved in the development and progression of HCC.
  
  
  
  miR-370 acted as the tumor suppressor in HCC and was a potential therapeutic target for HCC treatment.
authors.affiliation: The People's Hospital of Wuhai, Inner Mongolia, China. bnkrr524@sina.com.
authors.forename: X-P
authors.initials: XP
authors.lastname: Pan
authors.forename: H-X
authors.initials: HX
authors.lastname: Wang
authors.forename: D-M
authors.initials: DM
authors.lastname: Tong
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: L-H
authors.initials: LH
authors.lastname: Huang
authors.forename: C
authors.initials: C
authors.lastname: Wang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D051573:Proto-Oncogene Proteins c-pim-1 / Q000235:genetics / Q000378:metabolism
chemical_list: C526503:MIRN370 microRNA, human; D035683:MicroRNAs; C496634:PIM1 protein, human; D051573:Proto-Oncogene Proteins c-pim-1