title: The Contribution of Necroptosis in Neurodegenerative Diseases.
abstract: Over the past decades, cell apoptosis has been significantly reputed as an accidental, redundant and alternative manner of cell demise which partakes in homeostasis in the development of extensive diseases. Nevertheless, necroptosis, another novel manner of cell death through a caspase-independent way, especially in neurodegenerative diseases remains ambiguous. The cognition of this form of cell demise is helpful to understand other forms of morphological resemblance of necrosis. Additionally, the concrete signal mechanism in the regulation of necroptosis is beneficial to the diagnosis and treatment of neurodegenerative diseases. Recent studies have demonstrated that necroptotic inhibitor, 24(S)-Hydroxycholesterol and partial specific histone deacetylase inhibitors could alleviate pathogenetic conditions of neurodegenerative diseases via necroptosis pathway. In this review, we summarize recent researches about mechanisms and modulation of necroptotic signaling pathways and probe into the role of programmed necroptotic cell demise in neurodegenerative diseases such as Parkinson's disease, Multiple sclerosis, Amyotrophic lateral sclerosis.
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.|Medical College, Nantong University, Nantong, 226001, Jiangsu, China.
authors.forename: Lifei
authors.initials: L
authors.lastname: Shao
authors.affiliation: Department of Blood Transfusion, The Forth Affiliated Hospital of Nantong University, Yancheng, 224006, Jiangsu, China.|Center of Laboratory Medicine, Affiliate Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.|Medical College, Nantong University, Nantong, 226001, Jiangsu, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
authors.affiliation: Medical College, Nantong University, Nantong, 226001, Jiangsu, China.|Department of Neurology, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
authors.forename: Haizhen
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China. ntdxgyl@163.com.
authors.forename: Yilu
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D009336:Necrosis / Q000378:metabolism / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
keywords: Necroptosis; Neurodegenerative diseases; RIPK1; RIPK3; TNF