title: The Immaculate Carbapenemase Study.
abstract: Carbapenemase-producing organisms, or CPOs, are Gram-negative pathogens that produce a transmissible carbapenemase and are typically resistant to most (sometimes all) antibiotics. We now face a global CPO pandemic of high mortality. In this issue of theJournal of Clinical Microbiology, Karlowsky et al. (J Clin Microbiol 55:1638-1649, 2017, https://doi.org/10.1128/JCM.02316-16) report the results of an extensive global surveillance study that provide much-needed information that enhances our understanding of carbapenemase-producingEnterobacteriaceae(CPE) and which will be valuable for the development of improved strategies for CPE control and therapy of infections.
authors.affiliation: University of Louisville School of Medicine, Louisville, Kentucky, USA kenneth.thomson@louisville.edu.
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Thomson
mesh_terms: D001426:Bacterial Proteins; D004755:Enterobacteriaceae; D004756:Enterobacteriaceae Infections; D006801:Humans; D015378:Imipenem; D001618:beta-Lactamases
chemical_list: D001426:Bacterial Proteins; D015378:Imipenem; D001618:beta-Lactamases; C063912:carbapenemase