title: [Successful treatment of severe dabigatran intoxication with idarucizumab in a patient with acute kidney injury].
abstract: In the course of an uncomplicated sigmoidostomy a 63-year-old male who had severe comorbidity developed a critical bleeding due to dabigatran intoxication induced by acute kidney injury. Massive blood transfusions, tranexamic acid, Octaplex and haemodialysis were not effective. Administration of idarucizumab induced immediate clinical and paraclinical improvement. Dabigatran should be carefully administrated in patients who have any degree of renal insufficiency. Idarucizumab may be effective in severe bleeding caused by dabigatran.
authors.affiliation: christinagpoulsen@gmail.com.
authors.forename: Christina Gjerlev
authors.initials: CG
authors.lastname: Poulsen
authors.forename: Morten
authors.initials: M
authors.lastname: Bestle
authors.forename: Lene
authors.initials: L
authors.lastname: Boesby
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use*; D000991:Antithrombins / Q000506:poisoning*; D000069604:Dabigatran / Q000506:poisoning*; D062787:Drug Overdose / Q000188:drug therapy*; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013916:Thrombelastography
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000931:Antidotes; D000991:Antithrombins; C000594745:idarucizumab; D000069604:Dabigatran