title: Anti-obesity effect and protection of liver-kidney functions by Codium fragile sulphated polysaccharide on high fat diet induced obese rats.
abstract: The present study investigates the hypolipidemic effects of sulphated polysaccharide obtained from Codium fragile (CFSP) in induced obese rats (HFD). The results showed an increase in body weight of HFD rats by 21.56% as compared to control normal rats. Moreover, serum lipase activity underwent an increase which led to an increase in the levels of total cholesterol (T-Ch), triglycerides (TG) and low density lipoprotein cholesterol (LDL-Ch) in serum associeted with a decrease in the level of high density lipoprotein cholesterol (HDL-Ch) in untreated HFD rats. This diet has disrupted the antioxidant status by decreasing the activities of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX)) and subsequently an increase in thiobarbituric acid reactive substances (TBARS) level in liver and kidney of obese rats. All these disturbances are significantly corrected by CFSP administration with no fatty deposits in the liver and a protective effect against renal histological alteration. This confirms the important role of this polysaccharide in the fight against oxidative stress and the prevention of hyperlipidemia.
authors.affiliation: Laboratory of Plant Biotechnology, Faculty of Sciences of Sfax, 3038 Sfax, Tunisia. Electronic address: rihab_b86@hotmail.com.
authors.forename: Rihab Ben Abdallah
authors.initials: RBA
authors.lastname: Kolsi
authors.affiliation: Research Unit of Anatomy, Histology and Embryology, Faculty of Medicine, Sfax, Tunisia.
authors.forename: Neila
authors.initials: N
authors.lastname: Jardak
authors.affiliation: Department of Endocrinology, CHU Hedi Chaker, Sfax, Tunisia.
authors.forename: Faten
authors.initials: F
authors.lastname: Hajkacem
authors.affiliation: Biochemistry Laboratory, CHU Hedi Chaker, Sfax, Tunisia.
authors.forename: Rim
authors.initials: R
authors.lastname: Chaaben
authors.affiliation: Biodiversity Unit and Aquatic Ecosystems, Faculty of Sciences of Sfax, 3038 Sfax, Tunisia.
authors.forename: Imed
authors.initials: I
authors.lastname: Jribi
authors.affiliation: Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Tunisia.
authors.forename: Abdelfattah El
authors.initials: AE
authors.lastname: Feki
authors.affiliation: Research Unit of Anatomy, Histology and Embryology, Faculty of Medicine, Sfax, Tunisia.
authors.forename: Tarak
authors.initials: T
authors.lastname: Rebai
authors.affiliation: Biochemistry Laboratory, CHU Hedi Chaker, Sfax, Tunisia.
authors.forename: Kamel
authors.initials: K
authors.lastname: Jamoussi
authors.affiliation: Laboratory of Plant Biotechnology, Faculty of Sciences of Sfax, 3038 Sfax, Tunisia.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Fki
authors.affiliation: Laboratory of Biomass Valorization and Proteins Production in Eukaryotes, Center of Biotechnology of Sfax, University of Sfax, Tunisia.
authors.forename: Hafedh
authors.initials: H
authors.lastname: Belghith
authors.affiliation: Laboratory of Plant Biotechnology, Faculty of Sciences of Sfax, 3038 Sfax, Tunisia.
authors.forename: Karima
authors.initials: K
authors.lastname: Belghith
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D000460:Chlorophyta / Q000737:chemistry*; D059305:Diet, High-Fat / Q000009:adverse effects*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008049:Lipase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013431:Sulfates / Q000737:chemistry
chemical_list: D019440:Anti-Obesity Agents; D000975:Antioxidants; D008055:Lipids; D011134:Polysaccharides; D013431:Sulfates; D008049:Lipase
keywords: Antioxidant; Green alga; Hyperlipidemia; Liver-kidney functions