title: Comparison of enamel matrix derivative (Emdogain) and subepithelial connective tissue graft for root coverage in patients with multiple gingival recession defects: A randomized controlled clinical study.
abstract: OBJECTIVE
  The purpose of the present study was to compare the clinical efficiency of enamel matrix derivative (EMD) placed under a coronally advanced flap (CAF; test group), to a connective tissue graft (CTG) placed under a CAF (control group), in patients with multiple recession defects.
  
  
  METHODS
  Twelve patients with multiple Miller's Class I or II gingival recessions in contralateral quadrants of the maxilla were selected. The primary outcome variable was the change in depth of the buccal recession (REC), at 6 months (T6) after surgery. The secondary outcome parameters included the clinical attachment level (CAL), the probing pocket depth (PPD), and the width of keratinized gingiva (WKT) apical to the recession. Recession defects were randomly divided to the test or control group by using a computer-generated randomization list. Data were analyzed within the frame of Mixed Linear Models with the ANOVA method.
  
  
  RESULTS
  There were no statistically significantly differences observed between test and control groups in regards with the depth of buccal recession with a mean REC of 1.82 mm (CTG) and 1.72 mm (EMD) respectively. Similarly the mean PPD value was 1.3 mm for both groups at T6, while the respective value for CAL was 1.7 mm (EMD) and 1.8 mm (CTG). Statistically significant differences were observed only for the WKT, which were 3.0 mm and 3.6 mm for the test and control groups respectively (P < .001) at T6.
  
  
  CONCLUSIONS
  The use of EMD in conjunction with a CAF resulted in similar results as compared to the CTG plus CAF.
authors.forename: Angeliki
authors.initials: A
authors.lastname: Alexiou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vouros
authors.forename: Georgios
authors.initials: G
authors.lastname: Menexes
authors.forename: Antonis
authors.initials: A
authors.lastname: Konstantinidis
mesh_terms: D000328:Adult; D003238:Connective Tissue / Q000637:transplantation*; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005889:Gingival Recession / Q000601:surgery*; D005893:Gingivoplasty / Q000379:methods*; D006801:Humans; D008297:Male; D008437:Maxilla; D008875:Middle Aged; D013524:Surgical Flaps; D014092:Tooth Root / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins