title: Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells.
abstract: Fluoride is a common element in nature and our daily life, and excessive intake of this element can cause fluorosis and irreversible brain damage. The toxic effects of fluoride on the central nervous system may be attributed to the release of inflammatory cytokines and ROS. GSK3β is a key protein that modulates NF-κB activity and inflammatory cytokine levels and plays an important role in the Wnt signaling pathway. In this study, we found that fluoride altered the inflammatory status and oxidative stress by inhibiting Wnt signaling pathway activity. This study thus provides a valid basis for the fluorine-induced neuroinflammation injury theory.
authors.affiliation: Department of Neurology, Xuzhou Medical University Affiliated Hospital, No. 99 Huaihai Road, Xuzhou, Jiangsu Province, 221000, China.|Department of Neurology, Xuzhou Medical University Affiliated Hospital of Huaian, No. 62 Huaihainan Road, Huai'an, Jiangsu Province, 223002, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Neurology, Xuzhou Medical University Affiliated Hospital of Huaian, No. 62 Huaihainan Road, Huai'an, Jiangsu Province, 223002, China.
authors.forename: Lian-Dong
authors.initials: LD
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, 264000, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurology, Xuzhou Medical University Affiliated Hospital, No. 99 Huaihai Road, Xuzhou, Jiangsu Province, 221000, China.
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Li
authors.affiliation: Department of Neurology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, 264000, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ren
authors.affiliation: Department of Psychiatry and Psychology, Xuzhou Medical University Affiliated Xuzhou Oriental Hospital, No. 379 Tongshan Road, Xuzhou, Jiangsu Province, 221000, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry and Psychology, Xuzhou Medical University Affiliated Xuzhou Oriental Hospital, No. 379 Tongshan Road, Xuzhou, Jiangsu Province, 221000, China.
authors.forename: Ke-Tai
authors.initials: KT
authors.lastname: Guo
authors.affiliation: Department of Neurology, Xuzhou Medical University Affiliated Hospital, No. 99 Huaihai Road, Xuzhou, Jiangsu Province, 221000, China.
authors.forename: Hong-Xi
authors.initials: HX
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Xuzhou Medical University Affiliated Hospital, No. 99 Huaihai Road, Xuzhou, Jiangsu Province, 221000, China. gengdeqin@hotmail.com.
authors.forename: De-Qin
authors.initials: DQ
authors.lastname: Geng
authors.affiliation: Department of Psychiatry and Psychology, Xuzhou Medical University Affiliated Xuzhou Oriental Hospital, No. 379 Tongshan Road, Xuzhou, Jiangsu Province, 221000, China. amanzcy@live.cn.
authors.forename: Cai-Yi
authors.initials: CY
authors.lastname: Zhang
mesh_terms: D002460:Cell Line; D002490:Central Nervous System / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D005459:Fluorides / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced*; D017628:Microglia / Q000187:drug effects / Q000473:pathology*; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000187:drug effects*
chemical_list: D016207:Cytokines; D017382:Reactive Oxygen Species; D005459:Fluorides
keywords: DKK1; GSK3β; NaF; Wnt signaling pathway; neuroinflammation