title: The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis.
abstract: The liver is essential for the regulation of energy, protein and amino acids, as well as in other aspects of metabolism. To identify efficient indexes for evaluation of nutritional status and metabolic characteristics during different Child-Pugh stages of hepatitis B cirrhosis, 83 patients and 35 healthy individuals were enrolled in our study. We found that grip strength, triceps skinfold thickness (TSF), body fat and skeletal muscle of the patients were reduced compared to the control group (P<0.05). Ultra-high-performance liquid chromatography data combined with mass spectrometry (UPLC-MS) showed that levels of a variety of metabolites, including lysophosphatidylcholines (LysoPCs), glycerophosphocholine, ornithine and glucuronic acid were reduced in the serum of patients with hepatitis B cirrhosis (P<0.001). However, glycerophosphoserine and taurocholic acid levels were higher than in the control group (P<0.001). Moreover, grip strength was correlated with the Child-Pugh score (P<0.05). Serum albumin, total cholesterol, LDL, LysoPCs, glycerophosphocholine, ornithine, glucuronic acid, glycerophosphoserine and taurocholic acid were correlated with the Child-Pugh score (P<0.01). These findings suggested that grip strength and the above small molecular substances might be considered as sensitive and important indexes for evaluating nutritional status and metabolic characteristics of patients with hepatitis B cirrhosis, which may help assess prognosis and adjust nutritional treatment.
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, Tianjin, PR China.|Department of Gastroenterology and Hepatology, Tianjin Key Laboratory of Artificial Cells, Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin, PR China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, Tianjin, PR China.|Department of Gastroenterology and Hepatology, Tianjin Key Laboratory of Artificial Cells, Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin, PR China.
authors.forename: Weili
authors.initials: W
authors.lastname: Yin
authors.affiliation: Clinical Laboratory of Tianjin Third Central Hospital, Tianjin, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, Tianjin, PR China.|Department of Nutriology, Tianjin Third Central Hospital, Tianjin, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Nutriology, Tianjin Third Central Hospital, Tianjin, China.
authors.forename: Yumei
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Clinical Laboratory of Tianjin Third Central Hospital, Tianjin, China.
authors.forename: Shuye
authors.initials: S
authors.lastname: Liu
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, Tianjin, PR China.|Department of Gastroenterology and Hepatology, Tianjin Key Laboratory of Artificial Cells, Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin, PR China.
authors.forename: Baoxin
authors.initials: B
authors.lastname: Qian
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, Tianjin, PR China.|Department of Gastroenterology and Hepatology, Tianjin Key Laboratory of Artificial Cells, Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin, PR China.
authors.forename: Fengmei
authors.initials: F
authors.lastname: Wang
authors.affiliation: The Third Central Clinical College of Tianjin Medical University, Tianjin, PR China.|Department of Gastroenterology and Hepatology, Tianjin Key Laboratory of Artificial Cells, Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Han
mesh_terms: D002851:Chromatography, High Pressure Liquid; D020723:Glucuronic Acid / Q000378:metabolism*; D018737:Hand Strength; D006509:Hepatitis B / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism*; D008244:Lysophosphatidylcholines / Q000378:metabolism*; D013058:Mass Spectrometry; D009952:Ornithine / Q000378:metabolism*
chemical_list: D008244:Lysophosphatidylcholines; D020723:Glucuronic Acid; D009952:Ornithine