title: Management of Liddle Syndrome in Pregnancy: A Case Report and Literature Review.
abstract: Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and hypokalemia due to a gain-of-function mutation in the SCNN1B or SCNN1G genes which code for the epithelial sodium channel in the kidney. This leads to increased sodium and water reabsorption causing hypertension. We report a case of a 27-year-old pregnant woman who was admitted for hypertension and hypokalemia and later diagnosed and treated for Liddle syndrome using amiloride. Maintaining a high suspicion of Liddle syndrome in pregnancy is essential in such cases to be able to adequately and effectively treat the hypertension. Due to physiological effects of pregnancy, the dose of amiloride may need to be increased as gestational age progresses up to a maximum dose of 30 mg orally per day.
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Awadalla
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Manasi
authors.initials: M
authors.lastname: Patwardhan
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Adham
authors.initials: A
authors.lastname: Alsamsam
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Wayne State University, Detroit Medical Center, Detroit, MI, USA.
authors.forename: Nashat
authors.identifier: 0000-0002-5772-2659
authors.initials: N
authors.lastname: Imran