title: Down-regulation of adenosine monophosphate-activated protein kinase activity: A driver of cancer.
abstract: Adenosine monophosphate-activated protein kinase (AMPK), a serine/threonine protein kinase, is known as "intracellular energy sensor and regulator." AMPK regulates multiple cellular processes including protein and lipid synthesis, cell proliferation, invasion, migration, and apoptosis. Moreover, AMPK plays a key role in the regulation of "Warburg effect" in cancer cells. AMPK activity is down-regulated in most tumor tissues compared with the corresponding adjacent paracancerous or normal tissues, indicating that the decline in AMPK activity is closely associated with the development and progression of cancer. Therefore, understanding the mechanism of AMPK deactivation during cancer progression is of pivotal importance as it may identify AMPK as a valid therapeutic target for cancer treatment. Here, we review the mechanisms by which AMPK is down-regulated in cancer.
authors.affiliation: Department of Gastroenterology and Research Institute of Digestive Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Gastroenterology and Research Institute of Digestive Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Gastroenterology and Research Institute of Digestive Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Ke
authors.affiliation: Department of Gastroenterology and Research Institute of Digestive Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Lingyu
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Gastroenterology and Research Institute of Digestive Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, China.
authors.forename: Deqiang
authors.initials: D
authors.lastname: Huang
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000107:Acetylation; D015536:Down-Regulation; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D054875:Ubiquitination
chemical_list: D035683:MicroRNAs; D055372:AMP-Activated Protein Kinases
keywords: Adenosine monophosphate–activated protein kinase; energy metabolism; microRNA; phosphorylation; ubiquitination