title: Palladium-catalyzed, aminoquinoline-directed arylation of phosphonamidate and phosphinic amide sp3C-H bonds.
abstract: Aminoquinoline-directed, palladium-catalyzed sp3C-H bond arylation in phosphonamidates and phosphinic amides is reported. The reaction employs Pd(OAc)2as a catalyst at 10 mol% loading and cesium phosphate or potassium carbonate as a base in 1,2-dichlorobenzene as a solvent. The directing group can be removed under basic conditions to afford phosphonic acid esters. The chemistry described here is the first example of unactivated sp3C-H bond arylation by using a phosphorus-containing directing group.
authors.affiliation: Department of Chemistry, University of Houston, Houston, TX 77204-5003, USA. olafs@uh.edu.
authors.forename: Tung Thanh
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Olafs
authors.initials: O
authors.lastname: Daugulis