title: Role of MiRNAs in Inflammatory Bowel Disease.
abstract: Inflammatory bowel diseases (IBD), mainly including Crohn's disease and ulcerative colitis, are characterized by chronic inflammation of the gastrointestinal tract. Despite improvements in detection, drug treatment and surgery, the pathogenesis of IBD has not been clarified. A number of miRNAs have been found to be involved in the initiation, development and progression of IBD, and they may have the potential to be used as biomarkers and therapeutic targets. Here, we have summarized the recent advances about the roles of miRNAs in IBD and analyzed the contribution of miRNAs to general diagnosis, differential diagnosis and activity judgment of IBD. Furthermore, we have also elaborated the promising role of miRNAs in IBD-related cancer prevention and prognosis prediction.
authors.affiliation: The First Brigade of Student, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Cao
authors.affiliation: The First Brigade of Student, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
authors.forename: Wanli
authors.initials: W
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
authors.forename: Daiming
authors.initials: D
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China. hongliu180@126.com.
authors.forename: Liu
authors.initials: L
authors.lastname: Hong
mesh_terms: D001343:Autophagy; D015415:Biomarkers / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000502:physiology; D006706:Homeostasis / Q000235:genetics / Q000276:immunology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology / Q000503:physiopathology*; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Autophagy; Diagnosis; Immune homeostasis; Inflammatory bowel diseases; Intestinal epithelial barrier; MiRNA