title: Genetic basis of dentigerous cysts associated with supernumerary teeth: A narrative review.
abstract: In the present study, we sought to: (a) analyze the p53 gene status in dentigerous cysts (DC) associated with supernumerary teeth (ST) in a pair of siblings with ST, of whom one developed a DC; and (b) conduct a narrative review of the literature on ST associated with DC. Blood samples were obtained, and the isolated DNA was used to amplify exons 4-8 of the p53 gene using specific primers, and subsequently sequenced. No mutations were identified in the coding regions of the p53 gene. A review of the literature revealed a prevalence of DC associated with ST to be as high as 13.6%, and that 83% of the case reports performed enucleation of DC and removal of ST. Dentigerous cysts associated with ST in one sibling demonstrated that variations in phenotypes exist, and the absence of mutations cannot eliminate the potential influence of genetic risk factors.
authors.affiliation: School of Dentistry, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Anthonappa
authors.affiliation: The University of Hong Kong, Hong Kong, China.
authors.forename: Manikandan
authors.identifier: http://orcid.org/0000-0002-9156-3727
authors.initials: M
authors.lastname: Ekambaram
authors.affiliation: School of Dentistry, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Chaturi N G
authors.initials: CNG
authors.lastname: Neboda
authors.affiliation: School of Dentistry, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Nigel M
authors.initials: NM
authors.lastname: King
authors.affiliation: Private Practice, Hong Kong, China.
authors.forename: Abu-Bakr M
authors.initials: AM
authors.lastname: Rabie
mesh_terms: D002648:Child; D004247:DNA / Q000032:analysis; D016208:Databases, Factual; D003803:Dentigerous Cyst / Q000000981:diagnostic imaging / Q000235:genetics*; D005091:Exons; D016158:Genes, p53; D006801:Humans; D008297:Male; D016366:Open Reading Frames / Q000235:genetics; D014096:Tooth, Supernumerary / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics*
chemical_list: D004247:DNA
keywords: children; dentigerous cyst; p53 gene; risk factor; supernumerary teeth