title: Effect of nitric oxide to axonal degeneration in multiple sclerosis via downregulating monocarboxylate transporter 1 in oligodendrocytes.
abstract: Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS). Axonal degeneration, one of the main pathological characteristics of MS, is affected by nitric oxide (NO). In turn, NO induces mitochondrial dysfunction of neurons and glial cells. Inadequate glucose causes monocarboxylate transporter 1 (MCT1) to transfer lactate from oligodendrocytes (OLs) to neurons, which decreases MCT1 and results in energy substrate deficit (mainly lactate) in axons. The condition gradually leads to axonal degeneration. This study proposes that NO-induced MCT1 down-regulation in OLs may be involved in the pathological process of axonal degeneration, which eventually leads to MS.
authors.affiliation: Department of Physiology, Third Military Medical University, Chongqing 400038, China; Battalion 5 of Cadet Brigade, Third Military Medical University, Chongqing 400038, China.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Physiology, Third Military Medical University, Chongqing 400038, China; Battalion 5 of Cadet Brigade, Third Military Medical University, Chongqing 400038, China.
authors.forename: Minghong
authors.initials: M
authors.lastname: Lan
authors.affiliation: Department of Physiology, Third Military Medical University, Chongqing 400038, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Physiology, Third Military Medical University, Chongqing 400038, China. Electronic address: yaozhx@yahoo.com.
authors.forename: Zhongxiang
authors.initials: Z
authors.lastname: Yao
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism / Q000473:pathology*; D015536:Down-Regulation; D006801:Humans; D008928:Mitochondria / Q000473:pathology; D027501:Monocarboxylic Acid Transporters / Q000235:genetics* / Q000378:metabolism; D009103:Multiple Sclerosis / Q000209:etiology* / Q000473:pathology; D009410:Nerve Degeneration; D009569:Nitric Oxide / Q000502:physiology*; D009836:Oligodendroglia / Q000378:metabolism / Q000473:pathology
chemical_list: D027501:Monocarboxylic Acid Transporters; D009569:Nitric Oxide
keywords: Axonal degeneration; Lactate; Monocarboxylate transporter 1; Multiple sclerosis; Nitric oxide; Oligodendrocyte