title: Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity.
abstract: Interleukin-17-producing T helper (Th17) cells are critical for the host defense of bacterial and fungal pathogens and also play a major role in driving pathogenic autoimmune responses. Recent studies have indicated that the generation of Th17 cells from naïve CD4+T cells is coupled with massive cellular metabolic adaptations, necessary to cope with different energy and metabolite requirements associated with switching from a resting to proliferative state. Furthermore, Th17 cells have to secure these metabolic adaptations when facing nutrient-limiting environments, such as at the sites of inflammation. Accumulating data indicates that this metabolic reprogramming is significantly linked to the differentiation of T helper cells and, particularly, that the metabolic changes of Th17 cells and anti-inflammatory Forkhead box P3+regulatory T cells are tightly and reciprocally regulated. Thus, a better understanding of these processes could offer potential new targets for therapeutic interventions for autoimmune diseases. In this mini-review, we will highlight some of the recent advances and discoveries in the field, with a particular focus on metabolic demands of Th17 cells and their implications for autoimmunity.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne , Parkville, VIC , Australia.
authors.forename: Katrina J
authors.initials: KJ
authors.lastname: Binger
authors.affiliation: VIB Laboratory of Translational Immunomodulation, Hasselt University, BIOMED , Diepenbeek , Belgium.
authors.forename: Beatriz F
authors.initials: BF
authors.lastname: Côrte-Real
authors.affiliation: VIB Laboratory of Translational Immunomodulation, Hasselt University, BIOMED , Diepenbeek , Belgium.
authors.forename: Markus
authors.initials: M
authors.lastname: Kleinewietfeld
keywords: autoimmune diseases; glycolysis; immunometabolism; interleukin-17-producing T helper cells; oxidative phosphorylation; regulatory T cells