title: The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review.
abstract: Metabolic disease comprises a set of risk factors highly associated with obesity and insulin resistance and is a consequence of central adiposity, hyperglycemia, and dyslipidemia. Furthermore, obesity increases the risk of the development of metabolic disease due to ectopic fat deposition, low-grade inflammation, and systemic energy disorders caused by dysregulated adipose tissue function. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and has been reported to exhibit anticancer and anti-inflammatory properties. In addition, recently reported beneficial effects of piceatannol on hypercholesterolemia, atherosclerosis, and angiogenesis underscore its therapeutic potential in cardiovascular disease. However, investigation of its role in metabolic disease is still in its infancy. This review intensively summarizes in vitro and in vivo studies supporting the potential therapeutic effects of piceatannol in metabolic disease, including inhibition of adipogenesis and lipid metabolism in adipocytes, and regulation of hyperlipidemia, hyperglycemia, insulin resistance, and fatty acid-induced inflammation and oxidative stress.
authors.affiliation: 1 Department of Food Science, Purdue University , West Lafayette, Indiana, USA .
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kershaw
authors.affiliation: 1 Department of Food Science, Purdue University , West Lafayette, Indiana, USA .|2 Purdue Center for Cancer Research, Purdue University , West Lafayette, Indiana, USA .
authors.forename: Kee-Hong
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000818:Animals; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage*; D013267:Stilbenes / Q000008:administration & dosage*
chemical_list: D010936:Plant Extracts; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene
keywords: adipocytes; adipose tissue; bioavailability; insulin resistance; obesity; resveratrol