title: Staphylococcus lugdunensis: a neglected pathogen of infections involving fracture-fixation devices.
abstract: Cases of fracture-fixation device infection involving Staphylococcus lugdunensis are not frequent. The clinical characteristics and the choice of treatment strategies of these infections are not obviously known to date.
  
  
  
  We performed a review of fracture-fixation device infection involving S. lugdunensis managed by our centres.
  
  
  
  Among the 38 cases of fracture-fixation device infection involving S. lugdunensis, 53% were located in the tibia. Most of our cases (87%) were chronic infections. Purulent discharge, which occurred in 79% of cases, was the most frequent clinical symptom, followed by pain in 63%, local inflammation in 55%, and fever in 37%. Bacteremia and severe sepsis occurred in 10% and 18% of cases, respectively. Four cases (10%) were treated exclusively with antimicrobial treatment alone. Thirty-four cases (89%) were treated with a combination of surgery with antimicrobial therapy including surgical debridement, antibiotics and osteosynthesis device retention in six cases (16%), and osteosynthesis device removal in 27 cases (71%). The mean length of antibiotic treatment was 119 days. The relapse rate was high that was not related to selection of resistant strains. Polymicrobial infection had no impact on clinical outcome. A combination of surgery with antimicrobial therapy was identified as a significant prognostic factor associated with remission (p = 0.042).
  
  
  
  S. lugdunensis is probably involved in more infections than has been reported. Using appropriate microbiological methods laboratories should routinely identify the species of all coagulase-negative Staphylococci isolates involved in fracture-fixation device infection to better achieve the treatment strategies of fracture-fixation device infection involving S. lugdunensis.
authors.affiliation: , 19-21 Boulevard Jean Moulin, Marseille, 13005, France. sengpiseth@yahoo.fr.|Service de Maladies Infectieuses Tropicales et Infections Chroniques (MITIC), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. sengpiseth@yahoo.fr.|Aix-Marseille Université, Unité de recherche sur les maladies infectieuses et tropicales émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, Marseille, France. sengpiseth@yahoo.fr.
authors.forename: Piseth
authors.identifier: 0000-0002-0300-2728
authors.initials: P
authors.lastname: Seng
authors.affiliation: Service de Maladies Infectieuses Tropicales et Infections Chroniques (MITIC), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.
authors.forename: Madou
authors.initials: M
authors.lastname: Traore
authors.affiliation: Service de Microbiologie - Centre Hospitalo-Universitaire de Nîmes, Nîmes, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Lavigne
authors.affiliation: Unité d'infectiologie transversale, Centre Hospitalier du Pays d'Aix, Aix-en-Provence, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Maulin
authors.affiliation: Aix-Marseille Université, Unité de recherche sur les maladies infectieuses et tropicales émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, Marseille, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Lagier
authors.affiliation: Chirurgie Orthopédique et Traumatologique Adulte, Hôpital Privé Résidence du Parc, Marseille, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Thiery
authors.affiliation: Laboratoire de biologie médicale, Hôpital Privé La Casamance, Aubagne, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Levy
authors.affiliation: Service des Maladies infectieuses et Tropicales - Centre Hospitalo-Universitaire de Nice, Nice, France.
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Roger
authors.affiliation: Equipe Mobile d'Infectiologie, Hopital Joseph Ducuing, Toulouse, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Bonnet
authors.affiliation: Service des Maladies infectieuses et Tropicales - Centre Hospitalo-Universitaire de Nîmes, Nîmes, France.
authors.forename: Albert
authors.initials: A
authors.lastname: Sotto
authors.affiliation: , 19-21 Boulevard Jean Moulin, Marseille, 13005, France.|Service de Maladies Infectieuses Tropicales et Infections Chroniques (MITIC), IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France.|Aix-Marseille Université, Unité de recherche sur les maladies infectieuses et tropicales émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, Marseille, France.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003646:Debridement; D005260:Female; D006801:Humans; D016268:Internal Fixators / Q000009:adverse effects* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery; D057787:Staphylococcus lugdunensis
chemical_list: D000900:Anti-Bacterial Agents
keywords: Bacteria; Bone and joint infection; Fracture-fixation devices; Human; Infection; Internal fixation; Osteomyelitis; Osteosynthesis; Staphylococcus lugdunensis