title: Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges.
abstract: Green tea catechins (GTCs) are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human prostate cancer (PCa) chemoprevention. In the last decades, many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs' anticancer action can no longer be simplistically limited to their direct antioxidant/pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown that GTCs specifically interact with cellular targets, including cell surface receptors, lipid rafts, and endoplasmic reticulum, modulate gene expression through direct effect on transcription factors or indirect epigenetic mechanisms, and interfere with intracellular proteostasis at various levels. Many of the effects observed in vitro are dose and cell context dependent and take place at concentrations that cannot be achieved in vivo. Poor intestinal absorption together with an extensive systemic and enteric metabolism influence GTCs' bioavailability through still poorly understood mechanisms. Recent efforts to develop delivery systems that increase GTCs' overall bioavailability, by means of biopolymeric nanoparticles, represent the main way to translate preclinical results in a real clinical scenario for PCa chemoprevention.
authors.affiliation: Department of Medicine and Surgery, University of Parma, Via Gramsci 14, Parma 43126, Italy. valeria.naponelli@unipr.it.|Centre for Molecular and Translational Oncology (COMT), University of Parma, Parco Area delle Scienze 11/a, Parma 43124, Italy. valeria.naponelli@unipr.it.|National Institute of Biostructure and Biosystems (INBB), Viale Medaglie d'Oro 305, Rome 00136, Italy. valeria.naponelli@unipr.it.|Fondazione Umberto Veronesi, Piazza Velasca 5, Milan 20122, Italy. valeria.naponelli@unipr.it.
authors.forename: Valeria
authors.initials: V
authors.lastname: Naponelli
authors.affiliation: Department of Medicine and Surgery, University of Parma, Via Gramsci 14, Parma 43126, Italy. ileana.ramazzina@unipr.it.|Centre for Molecular and Translational Oncology (COMT), University of Parma, Parco Area delle Scienze 11/a, Parma 43124, Italy. ileana.ramazzina@unipr.it.|National Institute of Biostructure and Biosystems (INBB), Viale Medaglie d'Oro 305, Rome 00136, Italy. ileana.ramazzina@unipr.it.
authors.forename: Ileana
authors.initials: I
authors.lastname: Ramazzina
authors.affiliation: Department of Medicine and Surgery, University of Parma, Via Gramsci 14, Parma 43126, Italy. chiara.lenzi1@studenti.unipr.it.
authors.forename: Chiara
authors.initials: C
authors.lastname: Lenzi
authors.affiliation: Department of Medicine and Surgery, University of Parma, Via Gramsci 14, Parma 43126, Italy. saverio.bettuzzi@unipr.it.|Centre for Molecular and Translational Oncology (COMT), University of Parma, Parco Area delle Scienze 11/a, Parma 43124, Italy. saverio.bettuzzi@unipr.it.|National Institute of Biostructure and Biosystems (INBB), Viale Medaglie d'Oro 305, Rome 00136, Italy. saverio.bettuzzi@unipr.it.
authors.forename: Saverio
authors.initials: S
authors.lastname: Bettuzzi
authors.affiliation: Department of Medicine and Surgery, University of Parma, Via Gramsci 14, Parma 43126, Italy. federica.rizzi@unipr.it.|Centre for Molecular and Translational Oncology (COMT), University of Parma, Parco Area delle Scienze 11/a, Parma 43124, Italy. federica.rizzi@unipr.it.|National Institute of Biostructure and Biosystems (INBB), Viale Medaglie d'Oro 305, Rome 00136, Italy. federica.rizzi@unipr.it.
authors.forename: Federica
authors.initials: F
authors.lastname: Rizzi
keywords: antioxidant; chemoprevention; green tea catechins; mechanism of action; nanochemoprevention; prostate cancer