title: Expression of human epidermal growth factor receptor 2 in bladder urothelial carcinoma.
abstract: BACKGROUND
  Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. Despite many reports in the literature, the prognostic significance of this overexpression remains unclear. The aim of this study was to assess the expression of HER2 in urothelial bladder carcinomas and its association with clinical and pathological parameters.
  
  
  METHODS
  103 cases of UBC were diagnosed in our department between January 2014 and December 2015. The tumor specimens obtained by transurethral resection or cystectomy were evaluated by immunohistochemistry using HER2 antibody.
  
  
  RESULTS
  HER2 protein overexpression was present in 11.7% of cases and associated with tumor grade (p= 0.003) and pathological stage (p= 0.015). In multivariate analysis, HER2 overexpression was associated only with tumor grade (P= 0.04).
  
  
  CONCLUSIONS
  HER2 protein overexpression is noted in patients with high grade cancer. This expression may select patients for anti HER2 targeted therapy. Future larger and prospective studies will verify the frequency of HER2 alteration and the role of HER2 in the aggressive behavior.
authors.affiliation: Department of Pathology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.|Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.|Hôpital militaire Mohamed V, Hay Riad, BP10000 Rabat, Morocco.
authors.forename: Mohamed Reda
authors.identifier: 0000-0001-7325-4659
authors.initials: MR
authors.lastname: El Ochi
authors.affiliation: Department of Pathology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.|Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Oukabli
authors.affiliation: Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.|Laboratory of Biostatistics Clinical Research and Epidemiology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.
authors.forename: Elarbi
authors.initials: E
authors.lastname: Bouaiti
authors.affiliation: Department of Pathology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.|Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.
authors.forename: Hafsa
authors.initials: H
authors.lastname: Chahdi
authors.affiliation: Department of Pathology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.|Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.
authors.forename: Adil
authors.initials: A
authors.lastname: Boudhas
authors.affiliation: Department of Pathology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.|Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Allaoui
authors.affiliation: Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.|Department of Urology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Ameur
authors.affiliation: Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.|Department of Urology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abbar
authors.affiliation: Department of Pathology, Mohamed V Military Hospital, Hay Riad, Rabat, Morocco.|Faculty of Medicine and Pharmacy, Mohammed V University, Hay Riad, Rabat, Morocco.
authors.forename: Abderrahmane
authors.initials: A
authors.lastname: Al Bouzidi
keywords: Bladder; Carcinoma; HER2; Urothelial