title: p63 Adjusts Sugar Taste of Epidermal Layers.
abstract: p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting the cellular glycolic rate through a direct transcriptional regulation of the metabolic enzyme PFKFB3. This finding sheds light on mechanisms underlining p63 function in the skin and suggests a role for energetic metabolism in epidermal biology.
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester, UK. Electronic address: ia119@le.ac.uk.
authors.forename: Ivano
authors.initials: I
authors.lastname: Amelio
authors.affiliation: Medical Research Council, Toxicology Unit, Leicester, UK; Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Gerry
authors.initials: G
authors.lastname: Melino
authors.affiliation: Department of Experimental Medicine and Surgery, University of Rome "Tor Vergata", 00133 Rome, Italy; Biochemistry Laboratory, Istituto Dermopatico Immacolata (IDI-IRCCS), 00100 Rome, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Candi
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D002478:Cells, Cultured; D004040:Dietary Carbohydrates / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism*; D005786:Gene Expression Regulation; D006019:Glycolysis / Q000235:genetics; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics*; D012680:Sensitivity and Specificity; D013649:Taste / Q000235:genetics*
chemical_list: C081876:CKAP4 protein, human; D004040:Dietary Carbohydrates; D008565:Membrane Proteins