title: Emerging Roles of IL-33/ST2 Axis in Renal Diseases.
abstract: Renal diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have a great impact on health care systems worldwide. Similar to cardiovascular diseases, renal diseases are inflammatory diseases involving a variety of cytokines. Primary causes of renal injury include ischemia, uremic toxins, bacteremia, or nephrotoxicity. Inflammation represents an important component following kidney injury. Interleukin (IL)-33 is a member of the IL-1 cytokine family, which is widely expressed in epithelial barrier tissues and endothelial cells, and mediates both tissue inflammation and repair responses. IL-33 is released as a nuclear alarmin in response to tissue damage and triggers innate and adaptive immune responses by binding to its receptor, suppression of tumorigenicity 2 (ST2). Recent evidence from clinical and experimental animal studies indicates that the IL-33/ST2 axis is involved in the pathogenesis of CKD, renal graft injury, systemic lupus nephritis, and AKI. In this review, we discuss the pathological and tissue reparative roles of the IL-33/ST2 pathway in different types of renal diseases.
authors.affiliation: Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. wychen624@cgmh.org.tw.
authors.forename: Wei-Yu
authors.initials: WY
authors.lastname: Chen
authors.affiliation: Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. r5239@cgmh.org.tw.|Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. r5239@cgmh.org.tw.
authors.forename: Lung-Chih
authors.initials: LC
authors.lastname: Li
authors.affiliation: Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. jyang@adm.cgmh.org.tw.
authors.forename: Jenq-Lin
authors.initials: JL
authors.lastname: Yang
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D000072179:Interleukin-1 Receptor-Like 1 Protein / Q000378:metabolism*; D000067596:Interleukin-33 / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33
keywords: acute renal injury; chronic renal disease; inflammation; interleukin-33