title: Cut in translation: ribosome-dependent mRNA decay.
abstract: Transcription and translation are two complex mechanisms that are tightly coupled in prokaryotic cells. Even before the completion of transcription, ribosomes attach to the nascent mRNA and initiate protein synthesis. Remarkably, recent publications have indicated an association between translation and decay of certain mRNAs. In this issue ofThe EMBO Journal, Leroyet al(2017) depicts a fascinating mechanism of mRNA degradation, which involves the ribosome-associated ribonuclease Rae1 inBacillus subtilisIn a translation-dependent manner, Rae1 binds the ribosomal aminoacylation (A)-site and cleaves between specific codons of the targeted mRNA.
authors.affiliation: Department of Biochemistry, RNA Group, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Lalaouna
authors.affiliation: Department of Biochemistry, RNA Group, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Massé
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics; D014176:Protein Biosynthesis; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics; D012270:Ribosomes / Q000235:genetics*
chemical_list: D012333:RNA, Messenger