title: Comparison of ASPIRE Mechanical Thrombectomy Versus AngioJet Thrombectomy System in a Porcine Iliac Vein Thrombosis Model.
abstract: BACKGROUND
  Percutaneous mechanical thrombectomy device has become an important therapeutic armamentarium in the management of venous thromboembolism. In this study, we compare the efficacy and safety profile of the AngioJet thrombectomy device and ASPIRE thrombectomy system in a porcine venous thrombosis model.
  
  
  METHODS
  Twelve adult pigs underwent bilateral iliac venous thrombosis created by using a stent graft thrombosis model and subsequently underwent either AngioJet (n = 6) or ASPIRE mechanical thrombectomy (n = 6) 1 week later. Intravascular ultrasound (IVUS) was used to assess thrombectomy efficacy, and computed tomography was used to evaluate pulmonary embolism (PE). Hemolytic effect was measured by plasma-free hemoglobin (PfHgb). Iliac vein thrombogenicity was evaluated with radiolabeled platelet and fibrin deposition. Veins were harvested and evaluated with light microscopy and scanning electron microscopy (SEM).
  
  
  RESULTS
  Similar thrombectomy efficacy by IVUS evaluation was noted in both groups. Significant greater PE and hemolysis were identified in the AngioJet group compared to the ASPIRE group. The AngioJet group had greater reduction in WBC and platelet compared to the ASPIRE group. No difference was found in thrombogenicity, light microscopic evaluation, or SEM.
  
  
  CONCLUSIONS
  Both devices had similar thrombectomy efficacy and thrombogenicity response. The ASPIRE catheter incurred less PE and hemolysis compared to the AngioJet device. Vessel wall response by histological analysis and SEM was similar in both groups.
authors.affiliation: Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.
authors.forename: Roy J
authors.initials: RJ
authors.lastname: Weinberg
authors.affiliation: Department of Bioengineering, University of California, Los Angeles, CA.
authors.forename: Tamuru
authors.initials: T
authors.lastname: Okada
authors.affiliation: Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.
authors.forename: Aaron
authors.initials: A
authors.lastname: Chen
authors.affiliation: Department of Vascular Surgery, University Vascular Associates, Los Angeles, CA.
authors.forename: Walter
authors.initials: W
authors.lastname: Kim
authors.affiliation: Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.
authors.forename: Changyi
authors.initials: C
authors.lastname: Chen
authors.affiliation: Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX; Department of Vascular Surgery, University Vascular Associates, Los Angeles, CA. Electronic address: plin@bcm.edu.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Lin
mesh_terms: D000818:Animals; D000072226:Computed Tomography Angiography; D004195:Disease Models, Animal; D004867:Equipment Design; D006461:Hemolysis; D007084:Iliac Vein / Q000000981:diagnostic imaging / Q000648:ultrastructure; D061185:Mechanical Thrombolysis / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D008855:Microscopy, Electron, Scanning; D010690:Phlebography / Q000379:methods; D011655:Pulmonary Embolism / Q000209:etiology; D034421:Sus scrofa; D017131:Thrombectomy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D013997:Time Factors; D018084:Ultrasonography, Interventional; D020246:Venous Thrombosis / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*