title: Copper-catalyzed tandem aryl-halogen hydroxylation and CH2Cl2-based N,O-acetalization toward the synthesis of 2,3-dihydrobenzoxazinones.
abstract: The concise synthesis of 2,3-dihydro-4H-benzo[e][1,3]oxazin-4-ones has been accomplished by copper-catalyzed tandem reactions of o-halobenzamides, LiOH and dichloromethane. The aryl-halogen bond hydroxylation and subsequent N,O-acetalization on CH2Cl2are enabled under catalytic conditions which allows the generation of C(sp2)-O, C(sp3)-O and C(sp3)-N bonds to give the target products.
authors.affiliation: College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P.R. China. chemliuyunyun@jxnu.edu.cn.
authors.forename: Xuwen
authors.initials: X
authors.lastname: Chen
authors.forename: Wenyan
authors.initials: W
authors.lastname: Hao
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Liu