title: Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation.
abstract: Neuropathic pain is a chronic disease with hallmarks such as chronic allodynia and hyperalgesia. Previous studies have shown that the transforming growth factor-β superfamily acts as a protecting factor against neuropathic pain. In the current study, we found that growth and differentiation factor 10 (GDF10), which belongs to the transforming growth factor-β superfamily, is mainly expressed in the superficial layers of spinal dorsal horn neurons and it was dramatically downregulated after spinal nerve ligation and N-methyl-D-aspartate (NMDA) intrathecal infusion. Moreover, the decrease in GDF10 expression and increase in mechanical sensitivity could be blocked by MK-801, an antagonist of the NMDA receptor. These results suggest that the decreasing GDF10 may contribute toward neuropathic pain by facilitating NMDA receptor activation. Our findings shed new light on the understanding of the molecular mechanisms underlying neuropathic pain.
authors.affiliation: aState Key of Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University bDepartment of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Long
authors.initials: L
authors.lastname: Jiang
authors.forename: Botao
authors.initials: B
authors.lastname: Tan
authors.forename: Sen
authors.initials: S
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zheng
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Zaiyun
authors.initials: Z
authors.lastname: Long
authors.forename: Yamin
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000818:Animals; D016291:Dizocilpine Maleate / Q000008:administration & dosage; D055413:Growth Differentiation Factor 10 / Q000378:metabolism*; D008297:Male; D009437:Neuralgia / Q000378:metabolism*; D020671:Posterior Horn Cells / Q000378:metabolism*; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013127:Spinal Nerves / Q000293:injuries / Q000378:metabolism
chemical_list: C525786:Gdf10 protein, rat; D055413:Growth Differentiation Factor 10; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate