title: Autophagic degradation of focal adhesions underlies metastatic cancer dissemination.
abstract: Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is required for focal adhesion disassembly, Src-stimulated tumor cell motility, and metastasis.
authors.affiliation: The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA; Medical Scientist Training Program, The University of Chicago, Chicago, IL, USA; The Committee on Cancer Biology, The University of Chicago, Chicago, IL, USA.
authors.forename: Marina N
authors.initials: MN
authors.lastname: Sharifi
authors.affiliation: The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA; Medical Scientist Training Program, The University of Chicago, Chicago, IL, USA; Interdisciplinary Scientist Training Program, The University of Chicago, Chicago, IL, USA.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Mowers
authors.affiliation: The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA; The Committee on Cancer Biology, The University of Chicago, Chicago, IL, USA.
authors.forename: Kay F
authors.initials: KF
authors.lastname: Macleod
keywords: Autophagy; Src; cell motility; metastasis; paxillin