title: Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children.
abstract: Purpose. Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (MC4R) gene and rs6265 near the brain-derived neurotrophic factor (BDNF) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children. The aim of the present study is to investigate the associations between the SNPs and adiponectin that has a regulatory role in glucose and lipid metabolism.Methods. We examined the associations of the SNPs with adiponectin in Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. A total of 3503 children participated in the study.Results. The SNP rs6265 was significantly associated with adiponectin under an additive model (P= 0.02 and 0.024, resp.) after adjustment for age, gender, and BMI or obesity statuses. The SNP rs17782313 was significantly associated with low adiponectin under a recessive model. No statistical significance was found between the two SNPs and low adiponectin after correction for multiple testing.Conclusion. We demonstrate for the first time that the SNP rs17782313 nearMC4Rand the SNP rs6265 nearBDNFare associated with adiponectin in Chinese children. These novel findings provide important evidence that adiponectin possibly mediates MC4R and BDNF involved in obesity.
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Lijun
authors.identifier: 0000-0001-5876-8379
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Liwang
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Meixian
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
authors.forename: Jie
authors.identifier: 0000-0003-0630-8447
authors.initials: J
authors.lastname: Mi