title: Surgical-pathological findings in type 1 and 2 endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study on GOG-210 protocol.
abstract: To report clinical and pathologic relationships with disease spread in endometrial cancer patients.
  
  
  
  Surgical candidates with uterine cancer (adenocarcinoma or carcinosarcoma) who were eligible to participate in a surgical pathological study to create a clinically annotated tissue biorepository to support translational and clinical research studies. All patients were to undergo a hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy. From 2003-2007, open eligibility enrollment was conducted, and from 2007-2011, eligibility was restricted to enrich underrepresented patients or those at high risk.
  
  
  
  This report details clinical pathological relationships associated with extra uterine disease spread of 5866 evaluable patients including those with endometrioid histology as well as papillary serous, clear cell and carcinosarcoma histologies. Review of unrestricted enrollment was constructed in an effort to capture a cross-section population representative of endometrial cancers seen by the GOG participating members. Evaluation of this group of patients suggested the more natural incidence of different surgical pathological findings as well as demographic information. The addition of 2151 patients enrolled during the restricted time interval allowed a total of 1630 poor histotype patients available for further analysis. As expected, endometrioid (E) cancers represented the largest enrollment and particularly E grade 1 and 2 (G1 and 2) were more frequently confined to the uterus. Grade 3 (G3) endometrioid cancers as well as the poor histotype (papillary serous, clear cell and carcinosarcoma) had a much greater propensity for extant disease.
  
  
  
  This study confirms the previously reported surgical pathological findings for endometrioid cancers but in addition, using a large database of papillary serous, clear cell and carcinosarcoma, surgical pathological findings substantiate the categorization of poor histotypes for these cancers.
authors.affiliation: Department of Obstetrics & Gynecology, Medical University of South Carolina, Charleston, SC 29425, United States. Electronic address: creasman@musc.edu.
authors.forename: William T
authors.initials: WT
authors.lastname: Creasman
authors.affiliation: NRG Oncology/Gynecologic Oncology Group, Roswell Park Cancer Institute, Buffalo, NY 14263, United States.
authors.forename: Shamshad
authors.initials: S
authors.lastname: Ali
authors.affiliation: Division of Gynecologic Oncology, Washington University School of Medicine, Saint Louis, MO 63110, United States. Electronic address: mutchd@wudosis.wustl.edu.
authors.forename: David G
authors.initials: DG
authors.lastname: Mutch
authors.affiliation: Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, United States. Electronic address: rzaino@psu.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Zaino
authors.affiliation: Division of Gynecologic Oncology, Washington University School of Medicine, Saint Louis, MO 63110, United States. Electronic address: mpowell@wustl.edu.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Powell
authors.affiliation: Department of Gynecologic Oncology, The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States. Electronic address: robert-mannel@ouhsc.edu.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Mannel
authors.affiliation: Division of Gynecologic Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, United States. Electronic address: floor.backes@osumc.edu.
authors.forename: Floor J
authors.initials: FJ
authors.lastname: Backes
authors.affiliation: Department of Gynecologic Oncology, Women and Infants Hospital, Providence, RI 02905, United States. Electronic address: pdisilvestro@wihri.org.
authors.forename: Paul A
authors.initials: PA
authors.lastname: DiSilvestro
authors.affiliation: Department of Obstetrics, Gynecology and Women's Health, University of Minnesota Medical Center-Fairview, Minneapolis, MN 55455, United States. Electronic address: argenta@umn.edu.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Argenta
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Medicine, Stony Brook University Medical Center, Stony Brook, NY 11794, United States. Electronic address: michael.pearl@sbumed.org.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Pearl
authors.affiliation: Department of Gynecology, Roswell Park Cancer Institute, Buffalo, NY 14263, United States. Electronic address: shashi.lele@roswellpark.org.
authors.forename: Shashikant B
authors.initials: SB
authors.lastname: Lele
authors.affiliation: Department of Gynecologic Oncology, University of Colorado Cancer Center - Anschutz Cancer Pavilion, Aurora, CO 80045, United States. Electronic address: saketh.guntupalli@ucdenver.edu.
authors.forename: Saketh R
authors.initials: SR
authors.lastname: Guntupalli
authors.affiliation: Department of Obstetrics & Gynecology, Case Western Reserve University, Cleveland, OH 44106, United States. Electronic address: steven.waggoner@uhhospitals.org.
authors.forename: Steven
authors.initials: S
authors.lastname: Waggoner
authors.affiliation: Division of Gynecologic Oncology, Women's Cancer Center of Nevada, Las Vegas, NV 89169, United States. Electronic address: nspirtos@wccenter.com.
authors.forename: Nick
authors.initials: N
authors.lastname: Spirtos
authors.affiliation: Department of Gynecology Oncology, University of North Carolina at Chapel Hill, Raleigh, NC 27607, United States. Electronic address: jboggess@med.unc.edu.
authors.forename: John F
authors.initials: JF
authors.lastname: Boggess
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, United States. Electronic address: edwarp@mail.magee.edu.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Edwards
authors.affiliation: NRG Oncology/Gynecologic Oncology Group, Roswell Park Cancer Institute, Buffalo, NY 14263, United States. Electronic address: gfiliaci@gogstats.org.
authors.forename: Virginia L
authors.initials: VL
authors.lastname: Filiaci
authors.affiliation: Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. Electronic address: david.miller@utsouthwestern.edu.
authors.forename: David S
authors.initials: DS
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology* / Q000601:surgery*; D003430:Cross-Sectional Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D014481:United States / Q000453:epidemiology
keywords: Poor histotypes; Surgical-pathology