title: Characteristics of diurnal ventricular premature complex variation in right ventricular outflow tract arrhythmias after catheter ablation.
abstract: Diurnal variations in ventricular tachyarrhythmias (VAs) have been demonstrated in idiopathic arrhythmogenic heart disease. The electrophysiological characteristics of diurnal variations in idiopathic right ventricular outflow tract (RVOT) VA have not previously been elucidated. Sixty-two consecutive patients undergoing catheter ablation for idiopathic RVOT VA (mean age: 42.8 ± 12.3 years, 35 females) were enrolled. The diurnal variation type (group 1, n = 36) was defined as those patients who had most ventricular premature contractions (VPCs) during the night hours by preprocedure Holter recordings. Group 2 (n = 26) was defined as those patients who did not have significant VPC variations. The baseline characteristics and electrophysiological properties were collected and analyzed, and the rates of recurrence after catheter ablation were compared between the 2 groups. In this study, heart rate variability analysis demonstrated lower low frequency/high frequency ratios in group 1 than in group 2 (3.95 ± 3.08 vs 6.26 ± 5.33; P = 0.042). There were no significant differences in baseline characteristics, echocardiography and electrophysiological characteristics between the 2 groups. During a mean follow-up period of 13.5 ± 11.0 months, a total of 16 patients had VA recurrences, including 13 patients from group 1 and 3 patients from group 2 (36.1% vs 12.5%, P = 0.039). This study demonstrated the effect of the autonomic nervous system in idiopathic RVOT VAs and that the diurnal variation type leads to a higher recurrence rate after catheter ablation.
authors.affiliation: Division of Cardiology, Kaohsiung Medical University Hospital Division of Cardiology, Taipei Veterans General Hospital Institute of Clinical Medicine, and Cardiovascular Research Center, Faculty of Medicine, College of Medicine, National Yang-Ming Medical University, Taipei Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Shih-Jie
authors.initials: SJ
authors.lastname: Jhuo
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Lo
authors.forename: Shih-Lin
authors.initials: SL
authors.lastname: Chang
authors.forename: Yenn-Jiang
authors.initials: YJ
authors.lastname: Lin
authors.forename: Fa-Po
authors.initials: FP
authors.lastname: Chung
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Hu
authors.forename: Tze-Fan
authors.initials: TF
authors.lastname: Chao
authors.forename: Ta-Chuan
authors.initials: TC
authors.lastname: Tuan
authors.forename: Jo-Nan
authors.initials: JN
authors.lastname: Liao
authors.forename: Chin-Yu
authors.initials: CY
authors.lastname: Lin
authors.forename: Yao-Ting
authors.initials: YT
authors.lastname: Chang
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Lin
authors.forename: Rohit
authors.initials: R
authors.lastname: Walia
authors.forename: Abigail Louise D
authors.initials: ALD
authors.lastname: Te
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamada
authors.forename: Sunu Budhi
authors.initials: SB
authors.lastname: Raharjo
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Tang
authors.forename: Kun-Tai
authors.initials: KT
authors.lastname: Lee
authors.forename: Wen-Ter
authors.initials: WT
authors.lastname: Lai
authors.forename: Shih-Ann
authors.initials: SA
authors.lastname: Chen
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D017115:Catheter Ablation; D002940:Circadian Rhythm; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012008:Recurrence; D017180:Tachycardia, Ventricular / Q000503:physiopathology* / Q000601:surgery; D016896:Treatment Outcome; D016278:Ventricular Function, Right; D018879:Ventricular Premature Complexes / Q000503:physiopathology* / Q000601:surgery