title: Mucosal IgA and IFN-γ+CD8 T cell immunity are important in the efficacy of live Salmonella enteria serovar Choleraesuis vaccines.
abstract: Salmonellosis, a disease caused by non-typhoidal Salmonella strains which can be transmitted from swine to humans, is one of the leading public health problems around the world. Paratyphoid of swine is controlled by vaccinating swine with Salmonella enterica serovar Choleraesuis (S. Choleraesuis) live vaccine strain C500 in China. Although the vaccine has good prophylactic efficacy, the mechanism of immunogenicity is unclear. Using a C500-derived paratyphoid thermo-stable live vaccine (PTSL vaccine), we demonstrated that the PTSL vaccine induces strong primary and memory immune responses in piglets. Mucosal IgA and IFN-γ+/CD8+T cells induced by the PTSL vaccine play key roles in the protection of the host from Salmonella infection. Our findings have important implications on the development of new and improved vaccines against salmonellosis and using live-attenuated Salmonella as vaccine carriers.
authors.affiliation: Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, State Key Laboratory for Agrobiotechnology, National Animal Protozoa Laboratory &College of Veterinary Medicine, China Agricultural University, Beijing, China.|China Institute of Veterinary Drug Control, Beijing, China.
authors.forename: Liangquan
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, State Key Laboratory for Agrobiotechnology, National Animal Protozoa Laboratory &College of Veterinary Medicine, China Agricultural University, Beijing, China.|Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, State Key Laboratory for Agrobiotechnology, National Animal Protozoa Laboratory &College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yin
authors.affiliation: Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, State Key Laboratory for Agrobiotechnology, National Animal Protozoa Laboratory &College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Xianyong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, Jiangsu, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Chunjuan
authors.initials: C
authors.lastname: Huang
authors.affiliation: Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, State Key Laboratory for Agrobiotechnology, National Animal Protozoa Laboratory &College of Veterinary Medicine, China Agricultural University, Beijing, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Suo
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000378:metabolism; D007371:Interferon-gamma / Q000378:metabolism; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000517:prevention & control*; D019779:Salmonella enterica / Q000276:immunology*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D013601:T-Lymphocytes / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D014613:Vaccines, Attenuated; D007371:Interferon-gamma