title: Synthesis and Characterization of Novel Anchorlipids for Tethered Bilayer Lipid Membranes.
abstract: Tethered bilayer lipid membranes are versatile solid-supported model membrane systems. Core to these systems is an anchorlipid that covalently links a lipid bilayer to a support. The molecular structure of these lipids can have a significant impact on the properties of the resulting bilayer. Here, the synthesis of anchorlipids containing ester groups in the tethering part is described. The lipids are used to form bilayer membranes, and the resulting structures are compared with membranes formed using conventional anchorlipids or sparsely tethered membranes. All membranes showed good electrical sealing properties; the disulphide-terminated anchorlipids could be used in a sparsely tethered system without significantly reducing the sealing properties of the lipid bilayers. The sparsely tethered systems also allowed for higher ion transport across the membrane, which is in good correlation with higher hydration of the spacer region as seen by neutron scattering.
authors.affiliation: Flinders Centre for Nanoscalce Science and Technology and School of Chemical and Physical Sciences, Flinders University , Adelaide 5042, Australia.
authors.forename: Jakob
authors.initials: J
authors.lastname: Andersson
authors.affiliation: Flinders Centre for Nanoscalce Science and Technology and School of Chemical and Physical Sciences, Flinders University , Adelaide 5042, Australia.
authors.forename: Jacqueline J
authors.initials: JJ
authors.lastname: Knobloch
authors.affiliation: Flinders Centre for Nanoscalce Science and Technology and School of Chemical and Physical Sciences, Flinders University , Adelaide 5042, Australia.
authors.forename: Michael V
authors.initials: MV
authors.lastname: Perkins
authors.affiliation: Australian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organisation , Locked Bag 2001, Kirrawee DC, New South Wales 2234, Australia.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Holt
authors.affiliation: Flinders Centre for Nanoscalce Science and Technology and School of Chemical and Physical Sciences, Flinders University , Adelaide 5042, Australia.
authors.forename: Ingo
authors.identifier: 0000-0002-5933-6495
authors.initials: I
authors.lastname: Köper
mesh_terms: D008051:Lipid Bilayers; D015394:Molecular Structure
chemical_list: D008051:Lipid Bilayers