title: A neural mass model of cross frequency coupling.
abstract: Electrophysiological signals of cortical activity show a range of possible frequency and amplitude modulations, both within and across regions, collectively known as cross-frequency coupling. To investigate whether these modulations could be considered as manifestations of the same underlying mechanism, we developed a neural mass model. The model provides five out of the theoretically proposed six different coupling types. Within model components, slow and fast activity engage in phase-frequency coupling in conditions of low ambient noise level and with high noise level engage in phase-amplitude coupling. Between model components, these couplings can be coordinated via slow activity, giving rise to more complex modulations. The model, thus, provides a coherent account of cross-frequency coupling, both within and between components, with which regional and cross-regional frequency and amplitude modulations could be addressed.
authors.affiliation: Brain and Cognition Research Unit, KU Leuven, Leuven, Belgium.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Chehelcheraghi
authors.affiliation: Brain and Cognition Research Unit, KU Leuven, Leuven, Belgium.|Center for Cognitive Science, TU Kaiserslautern, Kaiserslautern, Germany.
authors.forename: Cees
authors.initials: C
authors.lastname: van Leeuwen
authors.affiliation: Brain and Cognition Research Unit, KU Leuven, Leuven, Belgium.
authors.forename: Erik
authors.initials: E
authors.lastname: Steur
authors.affiliation: Brain and Cognition Research Unit, KU Leuven, Leuven, Belgium.
authors.forename: Chie
authors.initials: C
authors.lastname: Nakatani
mesh_terms: D001921:Brain / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*