title: Molecular Analysis of Genetic Markers for Non-Hodgkin Lymphomas.
abstract: Molecular analysis complements the clinical and histopathologic tools used to diagnose and subclassify hematologic malignancies. The presence of clonal antigen-receptor gene rearrangements can help to confirm the diagnosis of a B or T cell lymphoma and can serve as a fingerprint of that neoplasm to be used in identifying concurrent disease at disparate sites or recurrence at future time points. Certain lymphoid malignancies harbor a characteristic chromosomal translocation, a finding that may have significant implications for an individual's prognosis or response to therapy. The polymerase chain reaction (PCR) is typically used to detect antigen-receptor gene rearrangements as well as specific translocations that can be supplemented by fluorescence in situ hybridization (FISH) and karyotype analysis. © 2017 by John Wiley & Sons, Inc.
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Lynette M
authors.initials: LM
authors.lastname: Sholl
authors.affiliation: Yale New Haven Hospital, New Haven, Connecticut.
authors.forename: Janina
authors.initials: J
authors.lastname: Longtine
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Frank C
authors.initials: FC
authors.lastname: Kuo
mesh_terms: D004252:DNA Mutational Analysis / Q000379:methods*; D015321:Gene Rearrangement / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D005819:Genetic Markers
keywords: antigen receptor gene rearrangements; lymphoma; translocations