title: Receptor of Advanced Glycation End Products Gene Polymorphism and Primary Open-Angle Glaucoma.
abstract: OBJECTIVE
  The purpose of this study was to investigate the potential association between primary open-angle glaucoma and receptor of advanced glycation end products (AGER) polymorphisms in a Greek population.
  
  
  METHODS
  This is a case-control study of 106 patients with primary open-angle glaucoma and 120 healthy control subjects of Greek origin surveyed for AGER polymorphisms (rs1051993 and rs2070600) and a potential correlation to primary open-angle glaucoma.
  
  
  RESULTS
  AGER polymorphisms showed no statistically significant difference between patients with primary open-angle glaucoma and healthy controls.
  
  
  CONCLUSIONS
  Our study did not find any significant association between AGER polymorphism and primary open-angle glaucoma. Since we cannot reject the possibility that oxidative stress is a crucial factor for the development of primary open-angle glaucoma, further studies may be needed to confirm the importance of the AGER gene in the glaucoma pathogenesis.
authors.affiliation: Electrophysiology Laboratory, 1st Department of Ophthalmology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Marilita M
authors.initials: MM
authors.lastname: Moschos
authors.forename: Irini
authors.initials: I
authors.lastname: Chatziralli
authors.forename: Anna
authors.initials: A
authors.lastname: Sioziou
authors.forename: Maria
authors.initials: M
authors.lastname: Gazouli
mesh_terms: D000368:Aged; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics* / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: C000593871:AGER protein, human; D000067759:Receptor for Advanced Glycation End Products; D004247:DNA
keywords: Advanced glycation end products; Genetics; Glaucoma; Open angle; Polymorphisms