title: Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing.
abstract: A-to-I RNA editing is an important process for generating molecular diversity in the brain through modification of transcripts encoding several proteins important for neuronal signaling. We investigated the relationships between the extent of editing at multiple substrate transcripts (5HT2C, MGLUR4, CADPS, GLUR2, GLUR4, and GABRA3) in brain tissue obtained from adult humans and rhesus macaques. Several patterns emerged from these studies revealing conservation of editing across primate species. Additionally, variability in the human population allows us to make novel inferences about the co-regulation of editing at different editing sites and even across different brain regions.
authors.affiliation: Vanderbilt Brain Institute and Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN, USA. richard.t.oneil@vanderbilt.edu.
authors.forename: Richard T
authors.initials: RT
authors.lastname: O'Neil
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.
authors.forename: Michael V
authors.initials: MV
authors.lastname: Morabito
authors.affiliation: Departments of Pharmacology, Molecular Physiology and Biophysics, and the Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Emeson
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D006801:Humans; D008253:Macaca mulatta; D017072:Neostriatum / Q000378:metabolism; D017393:RNA Editing / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D016601:RNA-Binding Proteins; C000595356:ADAR protein, human; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase