title: Metabolic control of myofibers: promising therapeutic target for obesity and type 2 diabetes.
abstract: Mammalian skeletal muscles are composed of two major fibre types (I and II) that differ in terms of size, metabolism and contractile properties. In general, slow-twitch type I fibres are rich in mitochondria and have a greater insulin sensitivity than fast-twitch type II skeletal muscles. Although not widely appreciated, a forced induction of the slow skeletal muscle phenotype may inhibit the progress of obesity and diabetes. This potentially forms the basis for targeting slow/oxidative myofibers in the treatment of obesity. In this context, a better understanding of the molecular basis of fibre-type specification and plasticity may help to identify potential therapeutic targets for obesity and diabetes.
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, China.|University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Yehui
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, China.|Hunan Co-Innovation Center of Safety Animal Production, CICSAP, Changsha, China.
authors.forename: Fengna
authors.initials: F
authors.lastname: Li
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, China.
authors.forename: Bie
authors.initials: B
authors.lastname: Tan
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, China.|Hunan Co-Innovation Center of Safety Animal Production, CICSAP, Changsha, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Yao
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences; National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, China.|Laboratory of Animal Nutrition and Human Health, School of Biology, Hunan Normal University, Changsha, China.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D058990:Molecular Targeted Therapy / Q000639:trends; D009119:Muscle Contraction / Q000502:physiology; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism*; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000628:therapy*; D014157:Transcription Factors; D014158:Transcription, Genetic; D015533:Transcriptional Activation / Q000502:physiology; D060449:Wnt Signaling Pathway / Q000502:physiology
chemical_list: D014157:Transcription Factors
keywords: Obesity; myofibers; signalling pathways; type 2 diabetes