title: Brugada-Phenocopy Induced by Propafenone Overdose and Successful Treatment: A Case Report.
abstract: BACKGROUND
  Brugada syndrome is an inherited arrhythmogenic disease that may cause sudden cardiac death due to ventricular fibrillation in young adults. Brugada syndrome caused by propafenone intoxication has been noted rarely in the literature. We report a rare case, Brugada phenocopy due to propafenone intoxication and its treatment.
  
  
  METHODS
  A 15-year-old girl having a seizure was brought to the emergency room. She took 1.5 g propafenone (Rythmol, Abbott, Chicago, IL, USA) for suicidal intention. She had metabolic acidosis. Long QRS interval and ST elevation in leads V1 through V3 were seen on electrocardiography. After bicarbonate infusion for 4 hours, haemodynamic and neurologic findings were recovered, and all electrocardiography abnormalities disappeared. The Brugada-like electrocardiography pattern was not recognized in her surface and 24-hour Holter electrocardiography at follow-up. Ajmaline challenge test was negative 2 weeks later.
  
  
  CONCLUSIONS
  Absence of symptoms and documented ventricular tachycardia, negative challenge test, and a negative family history demonstrated that the Brugada phenocopy was a transient finding in this case and related to propafenone intoxication.
authors.affiliation: Department of Pediatric Cardiology, Ankara Children's Hematology and Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Emre
authors.initials: ME
authors.lastname: Arı
authors.affiliation: Department of Pediatric Cardiology, Ankara Children's Hematology and Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Ekici
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use; D053840:Brugada Syndrome / Q000209:etiology*; D002641:Chicago; D004562:Electrocardiography / Q000379:methods; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D008874:Midazolam / Q000494:pharmacology / Q000627:therapeutic use; D011405:Propafenone / Q000009:adverse effects*; D012640:Seizures / Q000188:drug therapy / Q000209:etiology; D026941:Sodium Channel Blockers / Q000009:adverse effects; D013406:Suicide, Attempted / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D026941:Sodium Channel Blockers; D011405:Propafenone; D008874:Midazolam
keywords: Brugada-like electrocardiography pattern; children Brugada phenocopy.; propafenone