title: Human Genomic Signatures of Brain Oscillations During Memory Encoding.
abstract: Memory encoding is an essential step for all learning. However, the genetic and molecular mechanisms underlying human memory encoding remain poorly understood, and how this molecular framework permits the emergence of specific patterns of brain oscillations observed during mnemonic processing is unknown. Here, we directly compare intracranial electroencephalography recordings from the neocortex in individuals performing an episodic memory task with human gene expression from the same areas. We identify genes correlated with oscillatory memory effects across 6 frequency bands. These genes are enriched for autism-related genes and have preferential expression in neurons, in particular genes encoding synaptic proteins and ion channels, supporting the idea that the genes regulating voltage gradients are involved in the modulation of oscillatory patterns during successful memory encoding across brain areas. Memory-related genes are distinct from those correlated with other forms of cognitive processing and resting state fMRI. These data are the first to identify correlations between gene expression and active human brain states as well as provide a molecular window into memory encoding oscillations in the human brain.
authors.affiliation: Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Stefano
authors.initials: S
authors.lastname: Berto
authors.affiliation: Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Guang-Zhong
authors.initials: GZ
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: James
authors.initials: J
authors.lastname: Germi
authors.affiliation: Department of Neurosurgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Bradley C
authors.initials: BC
authors.lastname: Lega
authors.affiliation: Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Konopka
mesh_terms: D001931:Brain Mapping; D058256:Brain Waves / Q000235:genetics* / Q000502:physiology; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology; D000069280:Electrocorticography; D005260:Female; D015870:Gene Expression / Q000502:physiology; D053263:Gene Regulatory Networks; D056726:Genetic Association Studies; D023281:Genomics / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008433:Mathematics; D061212:Memory, Episodic; D019579:Neocortex / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen