title: Association of arginase I or nitric oxide-related factors with job strain in healthy workers.
abstract: This study evaluated the associations between job strain and arginase I in 378 healthy Japanese factory workers by a cross-sectional study measuring nitric oxide (NO)-related parameters (arginase I, L-arginine, exhaled nitric oxide (FeNO), and NOx), clinical parameters, and job strain using a Japanese version of the Job Content Questionnaire by Karasek. Arginase I and FEV1% were negatively correlated with job strain and positively correlated with job control and social support. FeNO and hs-CRP were negatively correlated with job strain. Multiple regression analysis showed negative association of arginase I with job strain and positive association with job control and social support in females. It is concluded that serum levels of arginase I may be useful biomarkers for the diagnosis of job stress in healthy female workers, although many factors can be influencing the data.
authors.affiliation: Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Keiki
authors.identifier: http://orcid.org/0000-0002-3561-2600
authors.initials: K
authors.lastname: Ogino
authors.affiliation: Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Eguchi
authors.affiliation: Department of Public Health, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Nagaoka
mesh_terms: D000328:Adult; D001119:Arginase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006282:Health Personnel; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D009784:Occupational Diseases / Q000097:blood* / Q000201:enzymology; D013315:Stress, Psychological / Q000097:blood* / Q000201:enzymology
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide; C574619:ARG1 protein, human; D001119:Arginase