title: Assessment of prognostic scores of brain metastases from lung adenocarcinoma with EGFR mutations.
abstract: The aim of this study was to analyze prognostic factors and evaluate the value of four prognostic scores including RPA, DS-GPA BS-BM, GGS for the EGFR mutant BM patients from lung adenocarcinoma treated with EGFR-TKI. Data of NSCLC were retrospectively reviewed from August 2010 to June 2015 using the medical database of Shanxi Provincial Cancer Hospital. Patients with BM from lung adenocarcinoma with mutant EGFR treated by EGFR-TKI or a combination of EGFR-TKI and WBRT were included. Potential prognostic factors were statistically examined. The C-index of each prognostic score was calculated. A total of 1063 BM patients with lung adenocarcinoma that had been identified with EGFR mutations were reviewed. A total of 104 patients that had been diagnosed with BM were confirmed to have mutant EGFR in primary tumors. These patients received treatment with EGFR-TKI or EGFR-TKI with WBRT to BM. The potential predictive factors in multivariable analysis included KPS (70 vs.70-80 vs. 90-100) and number of brain metastatic lesions. In the log-rank test, the indexes of RPA, DS-GPA BS-BM, and GGS were all significant predictors of OS. The C-indexes of each prognostic score were 0.79, 0.76, 0.77, and 0.74 in DS-GPA, RPA, GGS, and BS-BM, respectively. The indexes of RPA, DS-GPA BS-BM, GGS were applicable for asessing survival stratification in brain metastases from lung adenocarcinoma with presented EGFR mutations in our independent population. The DS-GPA appears to be the best predictive value. However, all four of the indexes could not evaluate the exact independent prognostic factors in multivariable analysis. A prognostic index specific for this group of patients was needed for targeted lung cancer therapy.
authors.affiliation: Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China. 3420010@163.com.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Jianhong
authors.initials: J
authors.lastname: Lian
authors.affiliation: Department of Pathology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China. jinhongxing1960@126.com.|Department of Medical Imageology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China. jinhongxing1960@126.com.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Weili
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Xiaqin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Sufang
authors.initials: S
authors.lastname: Jia
authors.affiliation: Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Jia
authors.affiliation: Department of Medical Imageology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Jiwei
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Chemotherapy, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Songyan
authors.initials: S
authors.lastname: Han
authors.affiliation: Department of Chemotherapy, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Pathology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Xi
authors.affiliation: Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, 030013, People's Republic of China.
authors.forename: Shengmin
authors.initials: S
authors.lastname: Lan
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics / Q000556:secondary* / Q000628:therapy*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D059248:Chemoradiotherapy; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D017567:Karnofsky Performance Status; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: Brain metastasis; Lung adenocarcinoma; Prognostic scores