title: Structure-efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds.
abstract: New derivatives of cyclodextrins were prepared in order to determine the relative importance of the structural key elements involved in the degradation of organophosphorus nerve agents. To avoid a competitive inclusion between the organophosphorus substrate and the iodosobenzoate group, responsible for its degradation, the latter group had to be covalently bound to the cyclodextrin scaffold. Although the presence of the α nucleophile iodosobenzoate was a determinant in the hydrolysis process, an imidazole group was added to get a synergistic effect towards the degradation of the agents. The degradation efficiency was found to be dependent on the relative position of the heterocycle towards the reactive group as well as on the nature of the organophosphorus derivative.
authors.affiliation: Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Letort
authors.affiliation: Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
authors.forename: Michaël
authors.initials: M
authors.lastname: Bosco
authors.affiliation: Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Cornelio
authors.affiliation: Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Brégier
authors.affiliation: DGA Maîtrise NRBC, Département Evaluation des effets des agents chimiques, 91710 Vert le Petit, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Daulon
authors.affiliation: Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Gouhier
authors.affiliation: Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
authors.forename: François
authors.initials: F
authors.lastname: Estour
keywords: cyclodextrin; decontamination; enzyme mimic; nerve agents; organophosphorus pesticides