title: Redox-responsive self-assembly of β-cyclodextrin and ferrocene double-headed amphiphilic molecules.
abstract: We present a redox-responsive self-assembly based on a unimolecular platform. Three double-headed amphiphilic molecules composed of β-cyclodextrin (β-CD) and ferrocene (Fc) each with an alkyl chain as a linker (βCD-Cm-Fc, m = 2, 6, and 10) were synthesized, and their self-assembly behaviors were investigated. The molecules self-assembled into polydisperse micelles that transformed into vesicles upon oxidization of the Fc moieties to Fc+. 2D1H NMR results suggest that although the three molecules formed aggregates with similar morphologies, their molecular configurations were different because of the different lengths of the alkyl chains. When the linker was a C2chain, no host-guest complexes were formed, whereas host-guest recognition was detected for linker lengths of C6and C10. For the oxidized state samples, there were no host-guest interactions for linker lengths of C2and C6, whereas the alkyl chain was locked in the cavity of β-CD by host-guest inclusion for the molecule with a C10linker. Moreover, reversible redox-responsive self-assemblies based on the three β-CD derivatives with a terminal Fc were successfully achieved. Our results enrich the field of β-CD/Fc reversible self-assembly systems, and provide a possible unimolecular host-guest complexation model in host-guest chemistry.
authors.affiliation: School of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, 100048, P. R. China. xubaoc@btbu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Shanshan
authors.initials: S
authors.lastname: Hao
authors.forename: Qiaoya
authors.initials: Q
authors.lastname: Zhai
authors.forename: Huichuang
authors.initials: H
authors.lastname: Guo
authors.forename: Baocai
authors.initials: B
authors.lastname: Xu
authors.forename: Haiming
authors.initials: H
authors.lastname: Fan