title: Long-term outcomes of children with symptomatic congenital cytomegalovirus disease.
abstract: To assess long-term outcomes of children with symptomatic congenital cytomegalovirus (CMV) disease detected at birth.
  
  
  
  We used Cox regression to assess risk factors for intellectual disability (intelligence quotient <70), sensorineural hearing loss (SNHL; hearing level ⩾25 dB in any audiometric frequency) and vision impairment (best corrected visual acuity >20 or based on ophthalmologist report).
  
  
  
  Among 76 case-patients followed through median age of 13 (range: 0-27) years, 56 (74%) had SNHL, 31 (43%, n=72) had intellectual disability and 18 (27%, n=66) had vision impairment; 28 (43%, n=65) had intellectual disability and SNHL with/without vision impairment. Microcephaly was significantly associated with each of the three outcomes. Tissue destruction and dysplastic growth on head computed tomography scan at birth was significantly associated with intellectual disability and SNHL.
  
  
  
  Infants with symptomatic congenital CMV disease may develop moderate to severe impairments that were associated with presence of microcephaly and brain abnormalities.
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Lanzieri
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Leung
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Caviness
authors.affiliation: National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: W
authors.initials: W
authors.lastname: Chung
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: M
authors.initials: M
authors.lastname: Flores
authors.affiliation: Texas Children's Hospital, Houston, TX, USA.
authors.forename: P
authors.initials: P
authors.lastname: Blum
authors.affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Bialek
authors.affiliation: Texas Children's Hospital, Houston, TX, USA.|P3S Corporation, San Antonio, TX, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Miller
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.|Texas Children's Hospital, Houston, TX, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Vinson
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.|Texas Children's Hospital, Houston, TX, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Turcich
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.|Texas Children's Hospital, Houston, TX, USA.
authors.forename: R G
authors.initials: RG
authors.lastname: Voigt
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.|Texas Children's Hospital, Houston, TX, USA.
authors.forename: G
authors.initials: G
authors.lastname: Demmler-Harrison
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital* / Q000503:physiopathology; D005260:Female; D005845:Georgia; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D008831:Microcephaly / Q000000981:diagnostic imaging*; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000453:epidemiology; D055815:Young Adult