title: The Role of Carboplatin in the Neoadjuvant Chemotherapy Treatment of Triple Negative Breast Cancer.
abstract: Triple negative breast (TNBC) cancer constitutes a heterogeneous group of disease with histologic and molecular differences. Complete pathologic response to neoadjuvant chemotherapy (NACT) in TNBC is associated with improved outcomes. Efforts have been made in identifying drug combinations that will increase the response rate to preoperative chemotherapy. In this review we present recent studies that have incorporated carboplatin (Cb) in the NACT of TNBC. We discuss the homologous recombination deficiency score and the somatic or germline mutation for BRCA as potential biomarkers for future selection of patients that could benefit from the addition of Cb to NACT.
authors.affiliation: Breast Cancer Research, Memorial Cancer Institute, Memorial Healthcare System , Hollywood, FL.
authors.forename: Aurelio Bartolome
authors.initials: AB
authors.lastname: Castrellon
authors.affiliation: Surgical Oncology Services & Pancreaticobiliary Center, Memorial Cancer Institute, Memorial Healthcare System , Hollywood, FL.
authors.forename: Ihor
authors.initials: I
authors.lastname: Pidhorecky
authors.affiliation: Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX.
authors.forename: Vicente
authors.initials: V
authors.lastname: Valero
authors.affiliation: Hematology/Oncology and Medical Director of Memorial Cancer Institute, Memorial Healthcare System , Hollywood, FL, USA.
authors.forename: Luis Estuardo
authors.initials: LE
authors.lastname: Raez
keywords: Breast cancer; neoadjuvant chemotherapy; platinum agents