title: Haematological cancers: improving outcomes. A summary of updated NICE service guidance in relation to Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS).
abstract: Haematological malignancies are a diverse group of cancers that affect the blood, bone marrow and lymphatic systems. Laboratory diagnosis of haematological malignancies is dependent on combining several technologies, including morphology, immunophenotyping, cytogenetics and molecular genetics correlated clinical details and classification according to the current WHO guidelines. The concept of the Specialised Integrated Haematological Malignancy Diagnostic Services (SIHMDS) has evolved since the UK National Institute for Health and Care Excellence (NICE) Improving Outcomes Guidance (IOG) in 2003 and subsequently various models of delivery have been established. As part of the 2016 update to the NICE IOG, these models were systematically evaluated and recommendations produced to form the basis for quality standards for future development of SIHMDS. We provide a summary of the systematic review and recommendations. Although the recommendations pertain to the UK National Health Service (NHS), they have relevance to the modern delivery of diagnostic services internationally.
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: John A
authors.identifier: http://orcid.org/0000-0001-6819-3476
authors.initials: JA
authors.lastname: Snowden
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Susan
authors.initials: S
authors.lastname: O'Connell
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: James
authors.initials: J
authors.lastname: Hawkins
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Dalley
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Jack
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Deepak
authors.initials: D
authors.lastname: Mannari
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: McNamara
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Mike
authors.initials: M
authors.lastname: Scott
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Geoff
authors.initials: G
authors.lastname: Shenton
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Soilleux
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: Fergus
authors.initials: F
authors.lastname: Macbeth
mesh_terms: D000293:Adolescent; D000328:Adult; D002173:Cancer Care Facilities; D003362:Cost-Benefit Analysis; D055088:Early Detection of Cancer; D005260:Female; D019337:Hematologic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012017:Referral and Consultation; D013048:Specimen Handling; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology; D055815:Young Adult
keywords: CYTOGENETICS; FLOW CYTOMETRY; HAEMATO-ONCOLOGY; HAEMATOPATHOLOGY; MOLECULAR GENETICS