title: Encapsulation systems for the delivery of hydrophilic nutraceuticals: Food application.
abstract: Increased health risk associated with the sedentary life style is forcing the food manufacturers to look for food products with specific or general health benefits e.g. beverages enriched with nutraceuticals like catechin, curcumin rutin. Compounds like polyphenols, flavonoids, vitamins are the good choice of bioactive compounds that can be used to fortify the food products to enhance their functionality. However due to low stability and bioavailability of these bioactives (both hydrophobic and hydrophilic) within the heterogeneous food microstructure and in the Gastro Intestinal Tract (GIT), it becomes extremely difficult to pass on the real health benefits to the consumers. Recent developments in the application of nano-delivery systems for food product development is proving to be a game changer which has raised the expectations of the researchers, food manufacturers and consumers regarding possibility of enhancing the functionality of bioactives within the fortified food products. In this direction, nano/micro delivery systems using lipids, surfactants and other materials (carbohydrates, polymers, complexes, protein) have been fabricated to stabilize and enhance the biological activity of the bioactive compounds. In the present review, current status of the various delivery systems that are used for the delivery of hydrophilic bioactives and future prospects for using other delivery systems that have been not completely explored for the delivery of hydrophilic bioactives e.g. niosomes; bilosomes, cubosomes are discussed.
authors.affiliation: School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. Electronic address: a.nayak.1@bham.ac.uk.
authors.forename: N P
authors.initials: NP
authors.lastname: Aditya
authors.affiliation: School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: Yadira Gonzalez
authors.initials: YG
authors.lastname: Espinosa
authors.affiliation: School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: Ian T
authors.initials: IT
authors.lastname: Norton
mesh_terms: D002214:Capsules; D019587:Dietary Supplements; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D055951:Functional Food; D057927:Hydrophobic and Hydrophilic Interactions
chemical_list: D002214:Capsules
keywords: Bioactives; Bioavailability; Delivery; Food; Hydrophilic; Nanoparticles; Stability