title: Contribution of Hormonal Cytology in Girls and Adolescents to Reproductive Health: A Traditional Technique Monitoring Recent Problems.
abstract: OBJECTIVE
  To study the contribution of hormonal cytology in contemporary disturbances of fertility.
  
  
  METHODS
  Over a 10-year period (2006-2015), 6,688 vaginal fornix cytologies of 2,350 patients were investigated. For a more detailed analysis, a 3-year period from 2013 to 2015 was chosen. Four hundred and fifty-two patients were investigated, many of them several times and for a period longer than the 3 years analyzed.
  
  
  RESULTS
  The main disorders examined and treated via a gentle hormonal medication support and life style corrections by a pediatric gynecologist were: pubertas praecox - thelarche praecox and early menarche; dysfunctional juvenile metrorrhagia; central and peripheral endocrine disorders; eating disorders - anorexia mentalis and bulimia; obesity; excessive sport activities; autoimmune disorders, and others. Normalization of the menstrual cycle was achieved while monitoring progress with a series of hormonal cytologies in a majority of patients.
  
  
  CONCLUSIONS
  Hormonal cytology is a non-invasive and economical method, illustrating the direct effect of steroid on target cells. It contributes to reproductive health support by: (a) indicating the possible need and type of steroid therapy; (b) monitoring the normalization of cycle disturbances; (c) ruling out or indicating the need for more detailed steroid metabolism investigation. Thus, it represents a basic but valuable means of examination in child and adolescent gynecology.
authors.affiliation: Institute of Pathology, 1st Faculty of Medicine, Charles University and Faculty General Hospital, Prague, Czech Republic.
authors.forename: Jaroslava
authors.initials: J
authors.lastname: Dušková
authors.forename: Barbara
authors.initials: B
authors.lastname: Goldová
authors.forename: Lenka
authors.initials: L
authors.lastname: Matiášková
authors.forename: Alena
authors.initials: A
authors.lastname: Beková
authors.forename: Jana
authors.initials: J
authors.lastname: Skřenková
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003581:Cytodiagnosis / Q000379:methods*; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D005298:Fertility; D006801:Humans; D007223:Infant; D007247:Infertility, Female / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008597:Menstrual Cycle / Q000187:drug effects; D008875:Middle Aged; D065006:Papanicolaou Test; D011237:Predictive Value of Tests; D011372:Progestins / Q000008:administration & dosage*; D015203:Reproducibility of Results; D060728:Reproductive Health; D013997:Time Factors; D016896:Treatment Outcome; D014621:Vagina / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D014626:Vaginal Smears; D055815:Young Adult
chemical_list: D004967:Estrogens; D011372:Progestins
keywords: Disorders of food intake; Disorders of menstrual cycle; Endocrine cytology; Hormonal cytology; Pediatric gynecology; Pubertas praecox; Reproductive health