title: Efficient construction of C-N and C-S bonds in 2-iminothiazoles via cascade reaction of enaminones with potassium thiocyanate.
abstract: A novel and highly efficient protocol has been developed for the regioselective synthesis of 2-iminothiazole derivatives with potential biochemical interest by the reaction of enaminones, potassium thiocyanate (KSCN), and N-bromo succinimide (NBS) under mild conditions. The reaction proceeds via the formation of α-bromo enaminones as a versatile intermediate followed by thiocyanation/intramolecular cyclization in a one pot manner. The developed method is particularly attractive due to various advantages including operational simplicity, mild conditions, being catalyst free, and high bond-forming efficiency. The proposed protocol explores the synthetic routes of thiazoles by using various functional enaminones.
authors.affiliation: Key Laboratory of Natural Pharmaceutical and Chemical Biology of Yunnan Province, School of Science Honghe, University Mengzi, Yunnan 661100, China. orangekaka@126.com.
authors.forename: Xue-Bing
authors.initials: XB
authors.lastname: Chen
authors.forename: Xue-Quan
authors.initials: XQ
authors.lastname: Wang
authors.forename: Jia-Na
authors.initials: JN
authors.lastname: Song
authors.forename: Qing-Li
authors.initials: QL
authors.lastname: Yang
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu