title: Near Fatal Poisoning by Isoniazid and Rifampicin.
abstract: Since six decades, Isoniazid and Rifampicin are used as first line drugs for treatment of tuberculosis. The minimum acute lethal or toxic dose of Rifampicin is not well established. However, non-fatal acute overdoses in adults have been reported with doses ranging from 9 to 12 gm and fatal acute overdoses with doses ranging from 14 to 60 gm. Isoniazid, if acutely ingested, even 1.5 to 2 gram may cause toxicity in adults. We report a case of Pott's spine on ATT, who took massive overdose of Rifampicin (>18 gm) and Isoniazid (>12 gm) and reported late (almost 36 hours) after ingestion. He was treated successfully with pyridoxine, hemodialysis and supportive care.
authors.affiliation: Senior Consultant and Head, Department of Internal Medicine.
authors.forename: Arun
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Consultant, Department of Pathology.
authors.forename: Samiksha
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Associate Consultant, Critical Care.
authors.forename: Ritu
authors.initials: R
authors.lastname: Bansal
authors.affiliation: Resident, Critical Care.
authors.forename: Meghraj
authors.initials: M
authors.lastname: Meena
authors.affiliation: Clinical Director, Narayana Multispeciality Hospital, Jaipur, Rajasthan.
authors.forename: Mala
authors.initials: M
authors.lastname: Airun
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000506:poisoning*; D062787:Drug Overdose / Q000150:complications*; D006801:Humans; D007538:Isoniazid / Q000506:poisoning*; D008297:Male; D012293:Rifampin / Q000506:poisoning*; D012720:Severity of Illness Index; D014399:Tuberculosis, Spinal / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin