title: Paraoxonase and Arylesterase Levels in Behcet's Disease and Their Relations with the Disease Activity.
abstract: The aim of this study was to determine the paraoxonase (PON) and arylesterase (ARE) enzyme activity levels in Behcet's disease (BD) and to investigate whether they are associated with the disease activity. Twenty-six patients (study group) with active BD and 28 healthy controls (control group) were included in this study. While the patients who had at least one of the symptoms related to genital ulcer, skin lesions, active uveitis, arthritis, thrombophlebitis, or central nervous system involvement in addition to oral ulcers were considered as the active group, the patients who did not show clinical symptoms in the last one month due to the medical treatment were considered as the inactive group in the clinical evaluation of patients with BD. The PON and ARE levels were found to be significantly lower in the study group than the control group (p < 0.05). The PON levels of the active and inactive groups were 96.23 ± 57.84 and 112.2 ± 65.14, respectively. The ARE levels of the active and inactive groups were 30.49 ± 5.81 and 30.85 ± 6.40, respectively. No significant correlations were found between clinical findings and the activity levels of PON and ARE in the active patient group (p > 0.05). The activities of the antioxidant PON and ARE enzymes are reduced in BD. Therefore, it may be useful to add antioxidant therapy to the conventional treatment of the disease.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Erzurum Regional Training and Research Hospital, Erzurum, Turkey. drayhankul@gmail.com.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kul
authors.affiliation: Department of Physical Medicine and Rehabilitation, Medical Faculty, Ataturk University, Erzurum, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Uzkeser
authors.affiliation: Department of Biochemistry, Medical Faculty, Ataturk University, Erzurum, Turkey.
authors.forename: Nurinnisa
authors.initials: N
authors.lastname: Ozturk
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood*; D001528:Behcet Syndrome / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D000975:Antioxidants; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase
keywords: Antioxidant; Arylesterase; Behcet’s disease; Paraoxonase