title: Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation.
abstract: A 48-year-old man with hepatitis C virus (HCV) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. His course was complicated by fever, diarrhea, abdominal pain, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Biopsies of the colon and skin were consistent with acute graft-versus-host disease. Donor-derived lymphocytes were present in the peripheral blood. The patient was treated with corticosteroids and cyclosporine; however, he had minimal response to intensive immunosuppressive therapy. Extracorporeal photopheresis was initiated as a salvage therapy. He had a dramatic response, and his rash, diarrhea, and pancytopenia resolved. He is maintained on minimal immunosuppression 24 months later.
authors.affiliation: Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Brown
authors.affiliation: University of Texas Southwestern Medical School, Dallas, TX.
authors.forename: Cathy
authors.initials: C
authors.lastname: Gentry
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Suntrea T G
authors.initials: ST
authors.lastname: Hammer
authors.affiliation: Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Christine S
authors.initials: CS
authors.lastname: Hwang
authors.affiliation: Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Vusirikala
authors.affiliation: Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Prapti A
authors.initials: PA
authors.lastname: Patel
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Karén
authors.initials: K
authors.lastname: Matevosyan
authors.affiliation: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Shannan R
authors.initials: SR
authors.lastname: Tujios
authors.affiliation: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Arjmand R
authors.initials: AR
authors.lastname: Mufti
authors.affiliation: Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Collins