title: Nitric oxide: A new possible biomarker in heart failure? Relationship with pulmonary hypertension secondary to left heart failure.
abstract: Heart failure (HF) is a growing medical problem and it is of interest to study new biomarkers for better characterisation. In this sense, nitric oxide, reactive oxygen species (ROS), NADPH, and superoxide dismutase (SOD) were evaluated, along with their possible predictive value in patients with HF. An analysis was also performed on the potential differences between patients with and without secondary pulmonary hypertension (SPH), considered to have a worse prognosis. A significant decrease of nitric oxide and SOD was noted in HF, whereas ROS and NADPH were increased. These results agree with the pathophysiological changes characteristic of HF. It was also demonstrated that in patients with HF and SPH that nitric oxide and SOD were decreased when compared to HF without SPH, whereas ROS and NADPH were increased. Therefore, our results suggest that nitric oxide, ROS, NADPH, and SOD, could be considered as possible markers in HF, and could also characterise patients with SPH.
authors.affiliation: Unidad de Insuficiencia Cardíaca, Hospital Central, Mendoza, Argentina.
authors.forename: Roberto Jorge
authors.initials: RJ
authors.lastname: Bonafede
authors.affiliation: Laboratorio de Farmacología Experimental Básica y Traslacional, Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, UNCuyo, Mendoza, Argentina.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Calvo
authors.affiliation: Sección Ecocardiografía, Servicio de Cardiología, Hospital Central, Mendoza, Argentina.
authors.forename: Julia María Valeria
authors.initials: JMV
authors.lastname: Fausti
authors.affiliation: Servicio de Nutrición, Hospital Central, Mendoza, Argentina.
authors.forename: Sonia
authors.initials: S
authors.lastname: Puebla
authors.affiliation: Servicio de Cardiología, Hospital Luis Lagomaggiore, Mendoza, Argentina; Área de Medicina Interna, Facultad de Ciencias Médicas, UNCuyo, Mendoza, Argentina.
authors.forename: Adolfo Juan
authors.initials: AJ
authors.lastname: Gambarte
authors.affiliation: Unidad de Insuficiencia Cardíaca, Hospital Central, Mendoza, Argentina; Instituto de Medicina y Biología Experimental de Cuyo, Consejo Nacional de Investigación Científica y Tecnológica (IMBECU-CONICET), Mendoza, Argentina. Electronic address: wmanucha@yahoo.com.ar.
authors.forename: Walter
authors.initials: W
authors.lastname: Manucha
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000503:physiopathology; D009249:NADP / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D009249:NADP; D013482:Superoxide Dismutase
keywords: Biomarcadores; Biomarkers; Heart failure; Hipertensión pulmonar; Insuficiencia cardíaca; Pulmonary hypertension