title: Tumor Acidity/NIR Controlled Interaction of Transformable Nanoparticle with Biological Systems for Cancer Therapy.
abstract: Precisely controlling the interaction of nanoparticles with biological systems (nanobio interactions) from the injection site to biological targets shows great potential for biomedical applications. Inspired by the ability of nanoparticles to alter their physicochemical properties according to different stimuli, we explored the tumor acidity and near-infrared (NIR) light activated transformable nanoparticleDATAT-NPIR&DOX. This nanoparticle consists of a tumor acidity-activated TAT [the TAT lysine residues' amines was modified with 2,3-dimethylmaleic anhydride (DA)], a flexible chain polyphosphoester core coencapsulated a NIR dye IR-780, and DOX (doxorubicin). The physicochemical properties of the nanoparticle can be controlled in a stepwise fashion using tumor acidity and NIR light, resulting in adjustable nanobio interactions. The resulting transformable nanoparticleDATAT-NPIR&DOXefficiently avoids the interaction with mononuclear phagocyte system (MPS) ("stealth" state) due to the masking of the TAT peptide during blood circulation. Once it has accumulated in the tumor tissues,DATAT-NPIR&DOXis reactivated by tumor acidity and transformed into the "recognize" state in order to promote interaction with tumor cells and enhance cellular internalization. Then, this nanoparticle is transformed into "attack" state under NIR irradiation, achieving the supersensitive DOX release from the flexible chain polyphosphoester core in order to increase the DOX-DNA interaction. This concept provides new avenues for the creation of transformable drug delivery systems that have the ability to control nanobio interactions.
authors.affiliation: Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology , Guangzhou, Guandong 510006, P. R. China.|School of Medical Engineering, Hefei University of Technology , Hefei, Anhui, 230009, P. R. China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Li
authors.affiliation: School of Medical Engineering, Hefei University of Technology , Hefei, Anhui, 230009, P. R. China.
authors.forename: Yinchu
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology , Guangzhou, Guandong 510006, P. R. China.
authors.forename: Jinzhi
authors.initials: J
authors.lastname: Du
authors.affiliation: School of Medical Engineering, Hefei University of Technology , Hefei, Anhui, 230009, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tao
authors.affiliation: Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology , Guangzhou, Guandong 510006, P. R. China.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Du
authors.affiliation: Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology , Guangzhou, Guandong 510006, P. R. China.|School of Medical Engineering, Hefei University of Technology , Hefei, Anhui, 230009, P. R. China.
authors.forename: Xianzhu
authors.identifier: 0000-0002-1006-0950
authors.initials: X
authors.lastname: Yang
authors.affiliation: Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology , Guangzhou, Guandong 510006, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D045744:Cell Line, Tumor; D004396:Coloring Agents / Q000737:chemistry; D018736:DNA Adducts / Q000008:administration & dosage / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000737:chemistry*; D015696:Gene Products, tat / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry; D007259:Infrared Rays; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D009369:Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009842:Oligopeptides / Q000737:chemistry*; D010316:Particle Size; D000067996:RAW 264.7 Cells
chemical_list: C548458:2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium; D000970:Antineoplastic Agents; D004396:Coloring Agents; D018736:DNA Adducts; D005456:Fluorescent Dyes; D015696:Gene Products, tat; D007211:Indoles; D009842:Oligopeptides; C031902:doxorubicin-DNA; D004317:Doxorubicin
keywords: NIR-responsive; Nanobio interaction; activated TAT targeting; cancer therapy; tumor acidity-responsive