title: Unveiling the Impact of the Genomic Architecture on the Evolution of Vertebrate microRNAs.
abstract: Eukaryotic genomes frequently exhibit interdependency between transcriptional units, as evidenced by regions of high gene density. It is well recognized that vertebrate microRNAs (miRNAs) are usually embedded in those regions. Recent work has shown that the genomic context is of utmost importance to determine miRNA expression in time and space, thus affecting their evolutionary fates over long and short terms. Consequently, understanding the inter- and intraspecific changes on miRNA genomic architecture may bring novel insights on the basic cellular processes regulated by miRNAs, as well as phenotypic evolution and disease-related mechanisms.
authors.affiliation: Departamento de Genética e Biologia Evolutiva, Universidade de São Paulo São Paulo, Brazil.
authors.forename: Gustavo S
authors.initials: GS
authors.lastname: França
authors.affiliation: Department of Anesthesiology, Clinic of the University of Munich, Ludwig Maximilian University of Munich Munich, Germany.
authors.forename: Ludwig C
authors.initials: LC
authors.lastname: Hinske
authors.affiliation: Centro de Oncologia Molecular, Hospital Sírio-Libanês São Paulo, Brazil.
authors.forename: Pedro A F
authors.initials: PA
authors.lastname: Galante
authors.affiliation: Departamento de Genética e Biologia Evolutiva, Universidade de São Paulo São Paulo, Brazil.
authors.forename: Maria D
authors.initials: MD
authors.lastname: Vibranovski
keywords: expression breadth; host gene; intergenic region; intragenic; new and old miRNAs; target interactions