title: Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health.
abstract: Mycotoxins are secondary metabolites of fungi that grow on a variety of substrates. Due to their high consumption of cereals and their sensitivity, pigs are highly impacted by the presence of mycotoxins. At the European level, regulations and recommendations exist for several mycotoxins in pig feed. Among these toxins, fumonisin B1(FB1), and deoxynivalenol (DON) have a great impact on the intestine and the immune system. Indeed, the intestine is the first barrier to food contaminants and can be exposed to high concentrations of mycotoxins upon ingestion of contaminated feed. FB1and DON alter the intestinal barrier, impair the immune response, reduce feed intake and weight gain. Their presence in feed increases the translocation of bacteria; mycotoxins can also impair the immune response and enhance the susceptibility to infectious diseases. In conclusion, because of their effect on the intestine, FB1and DON are a major threat to pig health, welfare and performance.
authors.affiliation: ToxAlim Research Centre in Food Toxicology, INRA, UMR 1331, ENVT, INP Purpan, 180 chemin de Tournefeuille, BP93173, 31027 Toulouse, Cedex 03 France.|BIOMIN Research Center, Technopark 1, 3430 Tulln, Austria.
authors.forename: Alix
authors.initials: A
authors.lastname: Pierron
authors.affiliation: ToxAlim Research Centre in Food Toxicology, INRA, UMR 1331, ENVT, INP Purpan, 180 chemin de Tournefeuille, BP93173, 31027 Toulouse, Cedex 03 France.
authors.forename: Imourana
authors.initials: I
authors.lastname: Alassane-Kpembi
authors.affiliation: ToxAlim Research Centre in Food Toxicology, INRA, UMR 1331, ENVT, INP Purpan, 180 chemin de Tournefeuille, BP93173, 31027 Toulouse, Cedex 03 France.
authors.forename: Isabelle P
authors.initials: IP
authors.lastname: Oswald
keywords: Barrier function; Deoxynivalenol; Feed contamination; Fumonisin B1; Immune response; Intestine; Pig