title: A novel and useful predictive indicator of prognosis in ST-segment elevation myocardial infarction, the prognostic nutritional index.
abstract: OBJECTIVE
  The prognostic impact of poor nutritional status and cardiac cachexia in myocardial infarction is not clearly understood. Recent studies have implied a prognostic value of the prognostic nutritional index (PNI) in colorectal surgeries and postoperative septic complications. The present study aimed to evaluate the prognostic value of PNI in ST-segment elevation myocardial infarction (STEMI) patients.
  
  
  RESULTS
  We evaluated the in-hospital and long-term (3 years) prognostic impact of PNI on 1823 patients with STEMI undergoing primary percutaneous coronary intervention. Patients with lower PNI had significantly higher in-hospital and long-term mortality and major adverse cardiac events. After adjustment for all confounders, the in-hospital mortality rates were 7.9 times higher at the lower PNI level (95% CI: 5.0-15.8) than those at the higher PNI level. The long-term mortality rates were also 6.4 times higher at the lower PNI level (95% CI: 4.4-12.4) than those at the higher PNI level.
  
  
  CONCLUSIONS
  The present study demonstrated that the PNI, calculated based on the serum albumin level and lymphocyte count, is an independent prognostic factor for mortality in patients with STEMI.
authors.affiliation: Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey. Electronic address: drmuhammedkeskin@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Keskin
authors.affiliation: Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
authors.forename: M I
authors.initials: MI
authors.lastname: Hayıroğlu
authors.affiliation: Yeshiva University, Albert Einstein College of Medicine and Montefiore Medical Center, Department of Allergy/Immunology, Bronx, NY, USA.
authors.forename: T
authors.initials: T
authors.lastname: Keskin
authors.affiliation: Duzce University, Department of Cardiology, Duzce, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Kaya
authors.affiliation: Texas A&M University, Department of Cardiology, TX, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Tatlısu
authors.affiliation: Trakya University, Department of Cardiology, Edirne, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Altay
authors.affiliation: Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
authors.forename: A O
authors.initials: AO
authors.lastname: Uzun
authors.affiliation: Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
authors.forename: E B
authors.initials: EB
authors.lastname: Börklü
authors.affiliation: Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
authors.forename: T S
authors.initials: TS
authors.lastname: Güvenç
authors.affiliation: Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
authors.forename: I I
authors.initials: II
authors.lastname: Avcı
authors.affiliation: Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
authors.forename: Ö
authors.initials: Ö
authors.lastname: Kozan
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D018655:Lymphocyte Count; D008297:Male; D044342:Malnutrition / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000401:mortality; D010865:Pilot Projects; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D000072657:ST Elevation Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D012709:Serum Albumin / Q000032:analysis; D000075462:Serum Albumin, Human; D013997:Time Factors; D014421:Turkey
chemical_list: C422455:ALB protein, human; D015415:Biomarkers; D012709:Serum Albumin; D000075462:Serum Albumin, Human
keywords: Mortality; Myocardial infarction; Prognosis; Prognostic nutritional index