title: Obstetric care in women with genetic disorders.
abstract: The management of pregnant women who are themselves affected with genetic diseases is an increasingly relevant and important issue. Improvements in early diagnosis and management of genetic disease, as well as advances in assisted reproductive technology have impacted pregnancy rates in a cohort of women who may not have otherwise been able to conceive. A multidisciplinary approach is key to the management of pregnant women with complex health conditions, including genetic diseases. Pertinent issues should be addressed in the preconception, antepartum, intrapartum and postpartum periods to optimize maternal and fetal health. Additionally, counseling regarding risk of inheritance in offspring and options for prenatal diagnosis should be reviewed if available. This reviews aims to help provide background and insight into the management strategies for various commonly encountered and complex genetic conditions in the setting of pregnancy.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, 550 16th St, 7th Floor, University of California, San Francisco, CA 94143, USA. Electronic address: Shilpa.chetty@ucsf.edu.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Chetty
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, 550 16th St, 7th Floor, University of California, San Francisco, CA 94143, USA.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Norton
mesh_terms: D003376:Counseling; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics / Q000628:therapy*; D011295:Prenatal Care; D011296:Prenatal Diagnosis; D027724:Reproductive Techniques, Assisted
keywords: Turner syndrome; connective tissue disorder; cystic fibrosis; fatty oxidation disorders; phenylketonuria