title: Comparison of imipenem and meropenem antibiotics for the MALDI-TOF MS detection of carbapenemase activity.
abstract: A comparison of carbapenem molecules for the detection of carbapenemase-producing bacteria by MALDI-TOF MS showed that imipenem exhibited higher sensitivity (97%) and specificity (100%) scores for Pseudomonas aeruginosa than meropenem. However, meropenem was more efficient (98% sensitivity and 100% specificity) against Enterobacteriaceae.
authors.affiliation: Department of Microbiology, Faculty of Medicine and University Hospital in Plzen,Charles University, Plzen, Czech Republic; Biomedical Center, Faculty of Medicine, Charles University, Plzen, Czech Republic.
authors.forename: Veronika
authors.initials: V
authors.lastname: Rotova
authors.affiliation: Department of Microbiology, Faculty of Medicine and University Hospital in Plzen,Charles University, Plzen, Czech Republic; Biomedical Center, Faculty of Medicine, Charles University, Plzen, Czech Republic. Electronic address: c.papagiannitsis@gmail.com.
authors.forename: Costas C
authors.initials: CC
authors.lastname: Papagiannitsis
authors.affiliation: Department of Microbiology, Faculty of Medicine and University Hospital in Plzen,Charles University, Plzen, Czech Republic; Biomedical Center, Faculty of Medicine, Charles University, Plzen, Czech Republic.
authors.forename: Anna
authors.initials: A
authors.lastname: Skalova
authors.affiliation: Department of Microbiology, Faculty of Medicine and University Hospital in Plzen,Charles University, Plzen, Czech Republic; Biomedical Center, Faculty of Medicine, Charles University, Plzen, Czech Republic.
authors.forename: Katerina
authors.initials: K
authors.lastname: Chudejova
authors.affiliation: Department of Microbiology, Faculty of Medicine and University Hospital in Plzen,Charles University, Plzen, Czech Republic; Biomedical Center, Faculty of Medicine, Charles University, Plzen, Czech Republic.
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Hrabak
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000032:analysis / Q000378:metabolism*; D001431:Bacteriological Techniques / Q000379:methods; D015780:Carbapenems / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology; D015378:Imipenem / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013845:Thienamycins / Q000493:pharmacokinetics*; D001618:beta-Lactamases / Q000032:analysis / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; C063912:carbapenemase; D000077731:Meropenem
keywords: Carbapenems; Enterobacteriaceae; GES; IMP; Pseudomonas aeruginosa; VIM