title: [Generation of GABAergic interneuron-specific PGC-1α knockout mice].
abstract: OBJECTIVE
  To generate mice which are specific for peroxisomproliferator-activated receptor-γ coactivator-1(PGC-1α) knockout in the GABAergic interneuron.
  
  
  METHODS
  Conditional mice specific for PGC-1αf/+were introduced from the Jackson Laboratory, USA and initially inbred to obtain homozygote PGC-1αf/fmice. The PGC-1αf/fconditional mice were further crossed with Dlx5/6-Cre-IRES-EGFP transgenic mice to achieve specific knockout of PGC-1α in the GABAergic interneuron.
  
  
  RESULTS
  The offspring with specific knockout PGC-1α gene were successful for the generation of GABAergic interneuron, with the resulting genotype being PGC-1αf/f;Dlx5/6-Cre-IRES-EGFP.
  
  
  CONCLUSIONS
  The PGC-1αf/f;Dlx5/6-Cre-IRES-EGFPmice were obtained through a proper crossing strategy, which has provided a suitable platform for studying the function of PGC-1α in neuropsychiatric diseases.
authors.affiliation: School of Medical Science, Jiangsu University, Zhenjiang, Jiangsu 212013, China. weiningzhang99@gmail.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Wang
authors.forename: Xianlu
authors.initials: X
authors.lastname: Chang
authors.forename: Jinjun
authors.initials: J
authors.lastname: Qian
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wang
authors.forename: Yucong
authors.initials: Y
authors.lastname: Wang
authors.forename: Chi
authors.initials: C
authors.lastname: Feng
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Wang
authors.forename: Peihui
authors.initials: P
authors.lastname: Xia
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Danping
authors.initials: D
authors.lastname: Wu
authors.forename: Weining
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007395:Interneurons / Q000378:metabolism*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D019636:Neurodegenerative Diseases / Q000235:genetics*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Q000235:genetics*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D005680:gamma-Aminobutyric Acid