title: Positive surgical margin in robot-assisted radical prostatectomy: correlation with pathology findings and risk of biochemical recurrence.
abstract: BACKGROUND
  To analyze the correlation of surgical margin status with other findings on final pathology and risk of biochemical recurrence (BCR) in patients undergoing robot-assisted radical prostatectomy (RALP).
  
  
  METHODS
  Bundang Prostatectomy Database was reviewed to identify patients who underwent RARP from 2007 to 2011 and had a positive surgical margin (PSM) on final pathology. Pathology findings were reviewed. BCR-free survival was calculated using the Kaplan-Meier method. Cox univariable and multi-variable regression models were used to find the correlation between clinicopathologic factors and BCR.
  
  
  RESULTS
  Eight hundred and fifteen patients were included in the analysis: 118 (14.48%) had apical positive margin, 152 (18.65%) had a positive margin in another site, and 545 (66.87%) had negative surgical margins. In patients with only apical PSM, stratified by clinical stage, Kaplan-Meier analysis demonstrated significant difference in BCR-free survival between the groups (log rank P<0.001). Multivariable Cox proportional hazards model showed maximal percentage of positive core is the strongest predictor of BCR (HR=3.131, P<0.001). Multivariable Cox proportional hazards model showed PSM is one of the powerful predictor of postoperative BCR (HR=3.123, P<0.001).
  
  
  CONCLUSIONS
  PSM after RALP is one of the powerful predictor of BCR and apical PSM is relatively less powerful predictor of BCR. Maximal percentage of positive core is the most powerful preoperative predictors of BCR. Clinical stage and biopsy Gleason score are also associated with pathologic outcomes and BCR free survival rates in patients with positive apical margin only.
authors.affiliation: Department of Urology, Hanyang University Hospital, Seoul, South Korea.
authors.forename: Jung-Ki
authors.initials: JK
authors.lastname: Jo
authors.affiliation: Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.
authors.forename: Sung-Kyu
authors.initials: SK
authors.lastname: Hong
authors.affiliation: Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.
authors.forename: Seok-Soo
authors.initials: SS
authors.lastname: Byun
authors.affiliation: Department of Urology, Royal Melbourne Hospital, Melbourne, Australia.
authors.forename: Homayoun
authors.initials: H
authors.lastname: Zargar
authors.affiliation: Department of Urology, University Hospitals Case Medical Center, Cleveland, OH, USA.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Autorino
authors.affiliation: Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea - selee@snubh.org.
authors.forename: Sang-Eun
authors.initials: SE
authors.lastname: Lee
mesh_terms: D000368:Aged; D001706:Biopsy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D000072662:Margins of Excision; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D012371:Robotics / Q000379:methods*; D016019:Survival Analysis