title: How Factors Involved in the Resolution of Crystal-Induced Inflammation Target IL-1β.
abstract: One of the main clinical features characterizing crystal-induced inflammation is its spontaneous resolution. The aim of this review is to outline the various factors involved in the self-limiting course of crystal-induced inflammation focusing on their effect on IL-1β production. Endogenous molecules that are induced or locally recruited by the process itself, inhibitory proteins naturally present in the joint and exogenous dietary factors are discussed. Aside from the classical well-known molecules involved in the resolution of crystal-induced acute attack such as TGFβ, IL-10, IL-1Ra, and lipoproteins, particular attention is paid to recently uncovered mechanisms such as the aggregation of neutrophil extracellular traps, the release of ectosomes from neutrophil surface, and alpha-1-anti-trypsin-mediated IL-1 inhibition.
authors.affiliation: Rheumatology Unit, Department of Medicine - DIMED, University of Padova Padova, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Oliviero
authors.affiliation: Rheumatology Unit, Department of Medicine - DIMED, University of Padova Padova, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Scanu
keywords: crystal-induced inflammation; dietary factors; interleukin-1; lipoproteins; neutrophil extracellular traps; transforming growth factor