title: Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer.
abstract: Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, USA. syun@hms.harvard.edu and Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea.
authors.forename: Seonghoon
authors.identifier: http://orcid.org/0000-0002-1145-0336
authors.initials: S
authors.lastname: Kim
authors.affiliation: Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea.
authors.forename: HyeongChan
authors.initials: H
authors.lastname: Jo
authors.affiliation: Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea.
authors.forename: Mijeong
authors.identifier: http://orcid.org/0000-0001-5655-8650
authors.initials: M
authors.lastname: Jeon
authors.affiliation: Division of Gastroenterology, Dept. of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, Catholic University, Korea.
authors.forename: Myung-Gyu
authors.identifier: http://orcid.org/0000-0003-4083-5187
authors.initials: MG
authors.lastname: Choi
authors.affiliation: Department of Materials Science and Engineering, Pohang University of Science and Technology, Korea.
authors.forename: Sei Kwang
authors.identifier: http://orcid.org/0000-0002-7718-6259
authors.initials: SK
authors.lastname: Hahn
authors.affiliation: Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, USA. syun@hms.harvard.edu and Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea.
authors.forename: Seok-Hyun
authors.identifier: http://orcid.org/0000-0002-8903-5909
authors.initials: SH
authors.lastname: Yun
mesh_terms: D000818:Animals; D060807:Bioluminescence Resonance Energy Transfer Techniques; D006801:Humans; D008156:Luciferases / Q000737:chemistry / Q000378:metabolism*; D010778:Photochemotherapy; D048790:Renilla / Q000201:enzymology; D012395:Rose Bengal / Q000737:chemistry / Q000378:metabolism*; D026082:Singlet Oxygen / Q000378:metabolism*
chemical_list: D026082:Singlet Oxygen; D012395:Rose Bengal; D008156:Luciferases