title: Severe brachycephalic obstructive airway syndrome is associated with hypercoagulability in dogs.
abstract: We evaluated whether dogs with severe brachycephalic obstructive airway syndrome (BOAS) developed a hypercoagulable state similar to people with obstructive sleep apnea. Five dogs with grade 3 BOAS were included as well as 5 healthy control Labrador Retrievers. Venous blood samples were collected from each dog for performance of thromboelastography and determination of hematocrit and platelet count. Groups were compared using a t-test, with p < 0.05 considered significant. Thromboelastography results identified that all BOAS dogs were hypercoagulable compared to the Labradors, having significantly shortened clotting time with increased angle, maximal amplitude, and clot rigidity. BOAS dogs also had evidence of delayed fibrinolysis. These results are consistent with, but more severe than, those previously documented in apparently healthy Bulldogs. Together, these findings support the presence of a hypercoagulable state in brachycephalic dogs, and suggest that this state is amplified by increasing severity of BOAS.
authors.affiliation: Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA.
authors.forename: Courtney
authors.initials: C
authors.lastname: Crane
authors.affiliation: Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Rozanski
authors.affiliation: Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Abelson
authors.affiliation: Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA.
authors.forename: Armelle
authors.initials: A
authors.lastname: deLaforcade
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D003398:Craniosynostoses / Q000150:complications / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D005260:Female; D008297:Male; D015508:Nasal Obstruction / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D013916:Thrombelastography / Q000662:veterinary; D019851:Thrombophilia / Q000209:etiology / Q000662:veterinary*
keywords: Brachycephalic; dogs; hypercoagulability; thromboelastography