title: The SPOR Domain, a Widely Conserved Peptidoglycan Binding Domain That Targets Proteins to the Site of Cell Division.
abstract: Sporulation-related repeat (SPOR) domains are small peptidoglycan (PG) binding domains found in thousands of bacterial proteins. The name "SPOR domain" stems from the fact that several early examples came from proteins involved in sporulation, but SPOR domain proteins are quite diverse and contribute to a variety of processes that involve remodeling of the PG sacculus, especially with respect to cell division. SPOR domains target proteins to the division site by binding to regions of PG devoid of stem peptides ("denuded" glycans), which in turn are enriched in septal PG by the intense, localized activity of cell wall amidases involved in daughter cell separation. This targeting mechanism sets SPOR domain proteins apart from most other septal ring proteins, which localize via protein-protein interactions. In addition to SPOR domains, bacteria contain several other PG-binding domains that can exploit features of the cell wall to target proteins to specific subcellular sites.
authors.affiliation: Department of Microbiology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yahashiri
authors.affiliation: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Jorgenson
authors.affiliation: Department of Microbiology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA david-weiss@uiowa.edu.
authors.forename: David S
authors.initials: DS
authors.lastname: Weiss
mesh_terms: D001419:Bacteria / Q000166:cytology / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology*; D010457:Peptidoglycan / Q000378:metabolism*; D011485:Protein Binding; D000072417:Protein Domains; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins; D010457:Peptidoglycan
keywords: FtsN; cell division; divisome; murein