title: Restoration of Tear Secretion in a Murine Dry Eye Model by Oral Administration of Palmitoleic Acid.
abstract: Sea buckthorn (Hippophae rhamnoides)-derived products have traditionally been used as food and medicinal ingredients in Eastern countries. The purpose of this study was to investigate the effect of oral intake of sea buckthorn oil products on tear secretion using a murine dry eye model. Orally administered sea buckthorn pulp oil (not seed oil) restored aqueous tear secretion to its normal value under a dry eye condition. Palmitoleate (C16:1), a fatty acid present in sea buckthorn pulp oil, preserved tear secretion and suppressed inflammatory cytokines in the lacrimal gland to the same extent as that by pulp oil. These results suggest that an oral intake of sea buckthorn pulp oil has a potency to preserve tear secretion capacity in the dry eye state and palmitoleate, its main constituent fatty acid, is an active component of the oil. This effect may enable a potent diet-based treatment for the prevention of dry eye.
authors.affiliation: Gifu Shellac Manufacturing Co., Ltd., Gifu 500-8618, Japan. qqwp4kyq.izt@gmail.com.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Gifu Shellac Manufacturing Co., Ltd., Gifu 500-8618, Japan. rmshibuya@gmail.com.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Mori
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan. sono.hisayo2@gmail.com.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Imada
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan. e.oonishi@a5.keio.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Izuta
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan. snoopy-naoko@mvh.biglobe.ne.jp.
authors.forename: Michiko
authors.initials: M
authors.lastname: Shibuya
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan. tsubota@z3.keio.jp.
authors.forename: Hisayo
authors.initials: H
authors.lastname: Sakaguchi
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan. gsm.rd@gifushellac.co.jp.
authors.forename: Erina
authors.initials: E
authors.lastname: Oonishi
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan. gsm.rd2@gifushellac.co.jp.|Department of Allergy and Clinical Immunology, National Research Institute for Child Health & Development, Tokyo 157-8535, Japan. gsm.rd2@gifushellac.co.jp.
authors.forename: Naoko
authors.initials: N
authors.lastname: Okada
authors.affiliation: Department of Allergy and Clinical Immunology, National Research Institute for Child Health & Development, Tokyo 157-8535, Japan. matsumoto-k@ncchd.go.jp.
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan. tsubota@z3.keio.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D015352:Dry Eye Syndromes / Q000188:drug therapy*; D005227:Fatty Acids / Q000008:administration & dosage / Q000097:blood; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005260:Female; D031281:Hippophae / Q000737:chemistry*; D051379:Mice; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013666:Tears / Q000378:metabolism*
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D010938:Plant Oils; C008757:palmitoleic acid
keywords: dry eye; fatty acid; ophthalmology