title: [Right ventricular diastolic function in patients with lung diseases in the absence or presence of pulmonary hypertension].
abstract: OBJECTIVE
  To investigate the indicators of filling of the right ventricle (RV) in patients with chronic lung diseases with and without pulmonary hypertension (PH) compared to healthy individuals.
  
  
  METHODS
  365 people (198 men); mean age 64.6±8.0 years) were examined and divided into a group of patients with respiratory pathology without and with PH (n=124 and n=138, respectively) and a comparison group that included individuals without cardiovascular and respiratory diseases (n=103). All underwent echocardiography with examination of RV filling flows (Et, At, Et/At), data of the spectral tissue Doppler imaging of the fibrous ring of the tricuspid valve (e't, a't, e't/a't), and early tricuspid flow propagation velocity (ETFPV).
  
  
  RESULTS
  All the groups were found to have an e't/a't decrease to 0.75 (0.63-0.90) - 0.8 (0.63-1.0; p=0.26). The groups showed no noticeable differences in indicators, such as Еt/Аt, e't/a't, and Еt/e't ratios, although the increased size of the right heart was noted in patients without PH along with the ETFPV decrease from 33.5 (28-39) to 31.5 (24.5-36) cm/sec, which continued to substantially decline to 27.1 (24-35) cm/sec in patients with PH (p<0.0001).
  
  
  CONCLUSIONS
  Patients with chronic lung disease even without the development of PH exhibited a decreased ETFPV along with the increased size of the right heart. Another indicator of RV diastolic function is a tricuspid valve annular velocity ratio in early and late diastole; the e't/a't ratio was not considerably different in the groups, although its decline was observed in all the groups probably due to age-related changes. Thus, RV diastolic function should be comprehensively evaluated in patients with lung disease regardless of the presence of PH.
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Sumin
authors.affiliation: Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.
authors.forename: O G
authors.initials: OG
authors.lastname: Arkhipov
mesh_terms: D000367:Age Factors; D000368:Aged; D003971:Diastole; D015150:Echocardiography, Doppler / Q000379:methods; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology; D008171:Lung Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D014261:Tricuspid Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000175:diagnosis / Q000503:physiopathology