title: BiOSS LIM C: thin-strut cobalt-chromium version of the dedicated bifurcation stent.
abstract: Coronary bifurcation lesions pose therapeutic challenges during percutaneous coronary interventions. Dedicated bifurcation stents are one of the treatment options available. Areas covered: This paper will analyze the results of the BiOSS (Bifurcation Optimization Stent System) Clinical Program with a special focus on the cobalt-chromium BiOSS LIM C stent which has recently been introduced into the market (CE 2016). The stent is characterized by a strut thickness of 70 µm and sirolimus concentration of 1.4 µg/mm2. Expert commentary: The first BiOSS stent was a bare metal one, but shortly after a paclitaxel-eluting version was introduced - BiOSS Expert stent (CE 2010). After acceptable results of BiOSS Expert stent were obtained in registries as well as in the randomized clinical trial POLBOS I, a way for improvement was to change paclitaxel into the - olimus drug. Sirolimus has been chosen and the BiOSS LIM stent was developed (CE 2012). BiOSS LIM is the dedicated bifurcation stent with stainless steel platform that releases sirolimus (1.4 µg/mm2) from the surface of a biodegradable coating comprised of a copolymer of lactic and glycolic acids. Nevertheless, the idea to reduce late lumen loss and as a result TLR rate by using thinner struts appeared. Therefore, presently first-in-man registry with BiOSS LIM C is ongoing.
authors.affiliation: a Department of Invasive Cardiology , Central Clinical Hospital of the Ministry of the Interior and Administration , Warsaw , Poland.|b Polish Academy of Science , Mossakowski Medical Research Centre , Warsaw , Poland.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Gil
authors.affiliation: a Department of Invasive Cardiology , Central Clinical Hospital of the Ministry of the Interior and Administration , Warsaw , Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Bil
authors.affiliation: a Department of Invasive Cardiology , Central Clinical Hospital of the Ministry of the Interior and Administration , Warsaw , Poland.|b Polish Academy of Science , Mossakowski Medical Research Centre , Warsaw , Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kaczynski
authors.affiliation: c American Heart of Poland , Center for Cardiovascular Research and Development , Katowice , Poland.
authors.forename: Krzysztof P
authors.initials: KP
authors.lastname: Milewski
mesh_terms: D002857:Chromium; D003035:Cobalt; D003327:Coronary Disease / Q000473:pathology / Q000628:therapy*; D054855:Drug-Eluting Stents; D004867:Equipment Design; D006801:Humans; D020123:Sirolimus / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D002857:Chromium; D003035:Cobalt; D020123:Sirolimus
keywords: BiOSS LIM C; Dedicated bifurcation stent; cobalt-chromium; sirolimus-eluting stent