title: Fever after peripheral blood stem cell infusion in haploidentical transplantation with post-transplant cyclophosphamide.
abstract: OBJECTIVE
  Noninfection-related fever can occur after peripheral blood stem cell infusion in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide. The objective of this study was to analyze the incidence of fever and characterize some clinical features of affected patients.
  
  
  METHODS
  A retrospective case-series study with 40 patients who received haploidentical hematopoietic stem cell transplantation was carried out.
  
  
  RESULTS
  Thirty-three patients (82.5%) developed fever; no baseline characteristic was associated with its development. Median time to fever onset was 25.5h (range, 9.5-100h) and median peak temperature was 39.0°C (range, 38.1-40.5°C). Not a single patient developed hemodynamic or respiratory compromise that required admission to the intensive care unit. Fever was not explained by infection in any case. Ninety-one percent of the febrile episodes resolved within 96h of cyclophosphamide administration. No significant difference in overall survival, event-free survival, or graft versus host disease-free/relapse-free survival was found in the group of febrile individuals after peripheral blood stem cell infusion.
  
  
  CONCLUSIONS
  Fever after peripheral blood stem cell infusion in this clinical setting was common; it usually subsides with cyclophosphamide administration. The development of fever was not associated with an adverse prognosis.
authors.affiliation: Hematology Department, Hospital Pablo Tobón Uribe, Medellín, Colombia. Electronic address: mabju@yahoo.com.
authors.forename: Marcos
authors.initials: M
authors.lastname: Arango
authors.affiliation: Hematology Department, Hospital Pablo Tobón Uribe, Medellín, Colombia.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Combariza
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D000072916:Peripheral Blood Stem Cells / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D000075442:Transplantation, Haploidentical / Q000379:methods*; D055815:Young Adult
chemical_list: D003520:Cyclophosphamide
keywords: Cyclophosphamide; Fever; Haploidentical hematopoietic stem cell transplantation; Peripheral blood stem cell transplantation; Prognosis