title: Regression of Established Cardiac Fibrosis in Hypertensive Heart Disease.
abstract: Established cardiac fibrosis (ECF) with symptomatic heart failure preserved ejection fraction represents an ever-increasing segment of the hypertensive population. The regression of ECF with attendant improvement in myocardial stiffness and symptomatic failure represents an unmet health care need. Is the regression of ECF in hypertensive heart disease feasible and will stiffness and symptomatic failure be improved? What is the cellular/molecular signaling involved in its regression? What incremental knowledge is needed to proceed effectively? These issues are addressed in this Review.
authors.affiliation: Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors.forename: Karl T
authors.initials: KT
authors.lastname: Weber
authors.affiliation: Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors.forename: Yao
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Division of Endocrinology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors.forename: Ivan C
authors.initials: IC
authors.lastname: Gerling
authors.affiliation: Department of Microbiology, Immunology & Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
authors.forename: Ramareddy V
authors.initials: RV
authors.lastname: Guntaka
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D009202:Cardiomyopathies / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005355:Fibrosis; D006333:Heart Failure / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D058628:Myofibroblasts / Q000378:metabolism / Q000473:pathology; D012074:Remission Induction; D015398:Signal Transduction; D016896:Treatment Outcome; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents
keywords: blood pressure; cardiac fibrosis; hypertension; hypertensive heart disease; molecular signaling with fibrogenic and fibrolytic axes; myocardial stiffness; myofibroblast secretome