title: Single-step transepithelial photorefractive keratectomy in high myopia: qualitative and quantitative visual functions.
abstract: OBJECTIVE
  To investigate quantitative and qualitative optical outcomes of single-step transepithelial photorefractive keratectomy (TransPRK) in high myopia.
  
  
  METHODS
  In a prospective interventional case-series, 30 eyes with high myopia (-6.00 to -8.75 D) with (up to -3.00 D) or without astigmatism were enrolled from Bina Eye Hospital, Tehran, Iran. One-step TransPRK was performed with aberration-free aspherical optimized profile and SCHWIND AMARIS 500 laser. One-year follow-up results for refraction, visual acuities, vector analysis, ocular wave-front (OWF) and corneal wave-front (CWF) higher order aberrations (HOA), contrast sensitivity (CS), and post-operative haze were assessed.
  
  
  RESULTS
  After the surgery, both photopic and mesopic CSs significantly improved (bothP<0.001). We detected significant induction of OWF coma and trefoil (P<0.001 for both) HOAs; CWF coma (P=0.002), spherical (P<0.001), and tetrafoil (P=0.003) HOAs in 6 mm analysis diameter; and CWF trefoil (P=0.04) HOA in 4 mm analysis diameter. The range of mean induction observed for various HOAs was 0.005-0.11 µm. The 86.7% of eyes reached an uncorrected distance visual acuity of 20/20 or better; 96.7% of eyes were within ±0.5 D of targeted spherical refraction. In vector analysis, mean correction index value was 1.03 and mean index of success was 0.22. By 12mo after the operation, no eye lost any number of corrected distance visual acuity lines. We detected no corneal haze greater than 1+throughout the follow-up.
  
  
  CONCLUSIONS
  Our findings show promising effects of single-step TransPRK on quality of vision in high myopic eyes. It also improves refraction and visual acuity.
authors.affiliation: Bina Eye Hospital, Tehran 1634764651, Iran; TransPRK Research Group, Tehran 1586863813, Iran; Universal Council of Ophthalmology (UCO), Universal Scientific Education and Research Network (USERN), Tehran 1417613151, Iran.
authors.forename: Soheil
authors.initials: S
authors.lastname: Adib-Moghaddam
authors.affiliation: Bina Eye Hospital, Tehran 1634764651, Iran; TransPRK Research Group, Tehran 1586863813, Iran; Universal Council of Ophthalmology (UCO), Universal Scientific Education and Research Network (USERN), Tehran 1417613151, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Soleyman-Jahi
authors.affiliation: Bina Eye Hospital, Tehran 1634764651, Iran; TransPRK Research Group, Tehran 1586863813, Iran; Universal Council of Ophthalmology (UCO), Universal Scientific Education and Research Network (USERN), Tehran 1417613151, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Adili-Aghdam
authors.affiliation: Universal Council of Ophthalmology (UCO), Universal Scientific Education and Research Network (USERN), Tehran 1417613151, Iran; SCHWIND Eye-Tech-Solutions, Kleinostheim D-63797, Germany; Instituto de Oftalmobiología Aplicada, University of Valladolid, Valladolid 8-47002, Spain.
authors.forename: Samuel
authors.initials: S
authors.lastname: Arba Mosquera
authors.affiliation: Bina Eye Hospital, Tehran 1634764651, Iran; TransPRK Research Group, Tehran 1586863813, Iran; Universal Council of Ophthalmology (UCO), Universal Scientific Education and Research Network (USERN), Tehran 1417613151, Iran.
authors.forename: Niloofar
authors.initials: N
authors.lastname: Hoorshad
authors.affiliation: Bina Eye Hospital, Tehran 1634764651, Iran; TransPRK Research Group, Tehran 1586863813, Iran; Universal Council of Ophthalmology (UCO), Universal Scientific Education and Research Network (USERN), Tehran 1417613151, Iran.
authors.forename: Salar
authors.initials: S
authors.lastname: Tofighi
keywords: contrast sensitivity; high myopia; higher order aberrations; single-step transepithelial photorefractive keratectomy; transepithelial photorefractive keratectomy; vector analysis