title: Intestinal and neurological involvement in Behcet disease: a clinical case.
abstract: BACKGROUND
  Behcet's disease (BD) is a chronic immune-mediated, inflammatory disorder which may affect a number of different systems (oral and genital mucosa, eyes, skin, vascular district, joints, gastrointestinal tract and nervous system). Neurological manifestations are present in 5-10%, and gastrointestinal tract involvement in 10-15% of cases. The simultaneous involvement of two systems, neurological and gastrointestinal tract, is very rare and represents the aim of our case report.
  
  
  METHODS
  We describe a case of a 12-year-old girl with neurological (endocranial hypertension, papilledema, retinal vasculitis) and gastrointestinal tract (terminal ileum and cecum inflammation) involvement and with a history of recurrent oral aphthosis; therefore, according to both International Criteria for Behcet's Disease (ICBD) and Paediatric Behcet's Disease criteria (PEDBD) the diagnosis of BD was confirmed.
  
  
  CONCLUSIONS
  This case report is one of the few described in literature with simultaneous involvement of the two systems, neurological and gastrointestinal tract, in paediatric BD. The diagnosis is really difficult because there is no specific diagnostic test. We think that our clinical case should help clinicians to suspect a BD with an unusual onset.
authors.affiliation: Department of Human Pathology in Adulthood and Childhood "G. Barresi", Unit of Pediatrics, University of Messina, Messina, Italy. rgallizzi@unime.it.
authors.forename: Romina
authors.initials: R
authors.lastname: Gallizzi
authors.affiliation: Department of Human Pathology in Adulthood and Childhood "G. Barresi", Unit of Pediatrics, University of Messina, Messina, Italy.
authors.forename: Dominique
authors.initials: D
authors.lastname: De Vivo
authors.affiliation: Department of Human Pathology in Adulthood and Childhood "G. Barresi", Unit of Pediatrics, University of Messina, Messina, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Valenti
authors.affiliation: Department of Human Pathology in Adulthood and Childhood "G. Barresi", Unit of Pediatrics, University of Messina, Messina, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Pidone
authors.affiliation: Department of Human Pathology in Adulthood and Childhood "G. Barresi", Unit of Pediatric Surgery, University of Messina, Messina, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Romeo
authors.affiliation: Department of Human Pathology in Adulthood and Childhood "G. Barresi", Section of Anatomic Pathology, University of Messina, Messina, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: Caruso
authors.affiliation: Department of Human Pathology in Adulthood and Childhood "G. Barresi", Unit of Pediatrics, University of Messina, Messina, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Romano
mesh_terms: D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D001707:Biopsy, Needle; D002648:Child; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000601:surgery; D007150:Immunohistochemistry; D007813:Laparotomy / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D009422:Nervous System Diseases / Q000150:complications* / Q000000981:diagnostic imaging* / Q000628:therapy; D011379:Prognosis; D035583:Rare Diseases; D018570:Risk Assessment