title: Frequency of uterine sarcomas in patients admitted for uterine fibroid surgery.
abstract: To estimate the frequency of unsuspected uterine sarcoma identified postoperatively in women undergoing surgery for presumed benign uterine fibroids at a single university hospital.
  
  
  
  This was a retrospective single-center study; the records of all 2275 patients with uterine fibroids and uterine sarcomas from 2003 to 2015 were reviewed. Descriptive statistics were used to analyze demographic and clinical characteristics. To calculate confidence intervals (CIs), the Clopper-Pearson Exact method was applied.
  
  
  
  Preoperatively, 2269 patients had presumed benign uterine fibroids, and six patients had suspected uterine sarcoma. Among the 2269 patients who underwent surgery for presumed uterine fibroids, endometrial stromal sarcoma was histopathologically revealed in only one patient [0.044%, 95% CI: (0.001-0.25)] after laparoscopic subtotal hysterectomy with morcellation. All six patients who were preoperatively diagnosed having uterine sarcoma underwent direct conventional cancer treatment. Histopathologic analyses confirmed four cases of uterine leiomyosarcoma, one high-grade undifferentiated uterine sarcoma, and one embryonal rhabdomyosarcoma. Altogether, seven women were diagnosed as having uterine sarcomas over this twelve-year period.
  
  
  
  In our institution, the frequency of unsuspected uterine sarcomas was 1/2269 (0.044%) among women who underwent myomectomies and hysterectomies to treat presumed benign uterine fibroids.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Germany.
authors.forename: Liselotte
authors.initials: L
authors.lastname: Mettler
authors.affiliation: Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Germany.
authors.forename: Nicolai
authors.initials: N
authors.lastname: Maass
authors.affiliation: Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Germany.
authors.forename: Khulkar
authors.initials: K
authors.lastname: Abdusattarova
authors.affiliation: Institute of Medical Informatics and Statistics, University Hospital Schleswig-Holstein, Christian Albrecht-University, Kiel, Germany.
authors.forename: Astrid
authors.initials: A
authors.lastname: Dempfle
authors.affiliation: Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Germany.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Alkatout
keywords: Uterine fibroids; hysterectomy uterine sarcoma.; myomectomy