title: Novel ethanol-induced pectin-xanthan aerogel coatings for orthopedic applications.
abstract: In this study, we developed a novel high methoxyl pectin-xanthan aerogel coating on medical-grade stainless steel, prepared by ethanol-induced gelation and subsequent supercritical drying. Two non-steroidal anti-inflammatory drugs, i.e. diclofenac sodium and indomethacin, were incorporated into the aerogel coating. Electrochemical analyses were performed on the coated samples using electrochemical impedance spectroscopy and cyclic polarization techniques. The results showed that all passivated samples were highly resistant to general corrosion. The release of both non-steroidal anti-inflammatory drugs was complete after 24h, as confirmed by the plateau in the drug release profiles as well as by IR spectroscopy after the final release point. The potential of samples for use in orthopedic applications was evaluated on a human bone-derived osteoblast cell and all samples were shown to be biocompatible. The increased viability of some samples indicates the high potential of the developed approach for future evaluation of possible clinical use.
authors.affiliation: University of Maribor, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia.
authors.forename: Gabrijela
authors.initials: G
authors.lastname: Horvat
authors.affiliation: University of Maribor, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia; University of Tirana, Faculty of Natural Sciences, Boulevard "Zogu I", 1001 Tirana, Albania.
authors.forename: Klodian
authors.initials: K
authors.lastname: Xhanari
authors.affiliation: University of Maribor, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia.
authors.forename: Matjaž
authors.initials: M
authors.lastname: Finšgar
authors.affiliation: University of Maribor, Faculty of Medicine, Institute of Biomedical Sciences, Taborska ulica 8, SI-2000 Maribor, Slovenia.
authors.forename: Lidija
authors.initials: L
authors.lastname: Gradišnik
authors.affiliation: University of Maribor, Faculty of Medicine, Institute of Biomedical Sciences, Taborska ulica 8, SI-2000 Maribor, Slovenia.
authors.forename: Uroš
authors.initials: U
authors.lastname: Maver
authors.affiliation: University of Maribor, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia.
authors.forename: Željko
authors.initials: Ž
authors.lastname: Knez
authors.affiliation: University of Maribor, Faculty of Chemistry and Chemical Engineering, Smetanova ulica 17, 2000 Maribor, Slovenia. Electronic address: zoran.novak@um.si.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Novak
mesh_terms: D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003343:Corrosion; D004008:Diclofenac / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D000431:Ethanol; D005782:Gels; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage; D008422:Materials Testing; D010006:Osteoblasts / Q000187:drug effects; D010368:Pectins / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D005782:Gels; D011135:Polysaccharides, Bacterial; D004008:Diclofenac; D000431:Ethanol; D010368:Pectins; C002563:xanthan gum; D007213:Indomethacin
keywords: Coatings; Electrochemistry; Local drug delivery; Polysaccharide aerogel; Total hip arthroplasty