title: Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction.
abstract: Tanshinone IIA, extracted fromSalvia miltiorrhizaBunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone IIA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration. The number of hypertrophic and apoptotic dorsal root ganglion (L6-S1) cells was less after treatment with tanshinone IIA. The effects of tanshinone IIA were similar to intravenous injection of 30 mg/kg methylprednisolone. These findings suggested that tanshinone IIA improved functional recovery after spinal cord injury-induced lower urinary tract dysfunction by remodeling the spinal pathway involved in lower urinary tract control.
authors.affiliation: Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China; School of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Yang
authors.affiliation: Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Xing
authors.identifier: 0000-0002-7836-8716
authors.initials: X
authors.lastname: Yu
authors.affiliation: School of Materials Science and Engineering, Tsinghua University, Beijing, China.
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Mu
authors.affiliation: Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: He
keywords: detrusor-sphincter dyssynergia; dorsal root ganglion; lower urinary tract dysfunction; nerve regeneration; neural regeneration; neurogenic bladder; spinal cord injury; spinal pathway; tanshinone IIA; urodynamics