title: Resistance to Ceftazidime-Avibactam in Klebsiella pneumoniae Due to Porin Mutations and the Increased Expression of KPC-3.
authors.affiliation: Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA rhumphries@mednet.ucla.edu.
authors.forename: Romney M
authors.initials: RM
authors.lastname: Humphries
authors.affiliation: Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.
authors.forename: Peera
authors.identifier: 0000-0001-6182-9136
authors.initials: P
authors.lastname: Hemarajata
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D053961:Azabicyclo Compounds / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D002442:Ceftazidime / Q000494:pharmacology*; D004338:Drug Combinations; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018272:Porins / Q000235:genetics; D000073336:Whole Genome Sequencing; D065093:beta-Lactamase Inhibitors / Q000494:pharmacology*; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D053961:Azabicyclo Compounds; D001426:Bacterial Proteins; D004338:Drug Combinations; C092233:OmpK36 protein, Klebsiella pneumoniae; D018272:Porins; C000595613:avibactam, ceftazidime drug combination; D065093:beta-Lactamase Inhibitors; D002442:Ceftazidime; C107197:beta-lactamase SHV-11; C107198:beta-lactamase SHV-12; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae
keywords: KPC; OmpK35; OmpK36; ceftazidime-avibactam; resistance