title: Evaluation of structured lipids with behenic acid in the prevention of obesity.
abstract: Obesity affects all social classes, making it necessary to develop effective products that aid weight loss or help prevent weight gain. The objective of this work was to study the anti-obesity effects of structured lipids (SL) obtained by enzymatic interesterification, based on olive oil, soy oil and fully hydrogenated crambe oil. Twenty-four C57Bl/6 mice were distributed into four experimental groups according to the diet consumed: Control Diet (CD), Structured Lipids Diet (SLD), High-fat Control Diet (HCD), High-fat Structured Lipids Diet (HSLD). The animals that were fed SLs presented a smaller weight gain, despite a larger intake of the diet. The lowest weight gain was reflected in reduced amounts of adipose tissue and lower liver weight. A significant increase in lipids excreted by the animals in the feces was observed, despite there being no sign of toxicity or presence of diarrhea. The animals that consumed the HSLD presented lower total and LDL-cholesterol, increased HDL-cholesterol and increased hepatic arachidonic acid and docosahexaenoic acid levels. In addition, they did not develop hepatic steatosis. The study therefore showed that SLs could play a major role in combating or preventing obesity and other resultant diseases, without producing side effects.
authors.affiliation: Department of Food Science, School of Food Engineering, State University of Campinas, Monteiro Lobato street, 80, 13083-862 Campinas, SP, Brazil. Electronic address: deborakono@hotmail.com.
authors.forename: Débora Kono Taketa
authors.initials: DK
authors.lastname: Moreira
authors.affiliation: Clinical Pharmacology and Gastroenterology Unit, Medical Science Faculty, São Fransciso University, Av. São Francisco de Assis, 218, 12916-900, Bragança Paulista, SP, Brazil. Electronic address: pa.s.santos@hotmail.com.
authors.forename: Paola Souza
authors.initials: PS
authors.lastname: Santos
authors.affiliation: Clinical Pharmacology and Gastroenterology Unit, Medical Science Faculty, São Fransciso University, Av. São Francisco de Assis, 218, 12916-900, Bragança Paulista, SP, Brazil. Electronic address: alessandra.gambero@usf.edu.br.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gambero
authors.affiliation: Department of Food Science, School of Food Engineering, State University of Campinas, Monteiro Lobato street, 80, 13083-862 Campinas, SP, Brazil; Department of Food and Nutrition, School of Food Engineering, State University of Campinas, Monteiro Lobato St. 80, 13083-862 Campinas, SP, Brazil. Electronic address: macedoga@gmail.com.
authors.forename: Gabriela Alves
authors.initials: GA
authors.lastname: Macedo
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D016718:Arachidonic Acid; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat; D004281:Docosahexaenoic Acids / Q000494:pharmacology; D004734:Energy Metabolism; D005227:Fatty Acids / Q000494:pharmacology*; D005234:Fatty Liver / Q000517:prevention & control; D005243:Feces / Q000737:chemistry; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000517:prevention & control*; D000069463:Olive Oil / Q000737:chemistry; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain
chemical_list: D019440:Anti-Obesity Agents; D001786:Blood Glucose; D005227:Fatty Acids; D007328:Insulin; D000069463:Olive Oil; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D002784:Cholesterol; C007547:behenic acid
keywords: Anti-obesity lipids; Arachidonic acid; Behenic acid; Docosahexaenoic acid; High-fat diet, hepatic steatosis