title: Comparative Diagnostic Accuracy of the ACE-III, MIS, MMSE, MoCA, and RUDAS for Screening of Alzheimer Disease.
abstract: Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD).
  
  
  
  We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties of the following tests were compared: Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination III (ACE-III), Memory Impairment Screen (MIS), Montreal Cognitive Assessment (MoCA), and Rowland Universal Dementia Assessment Scale (RUDAS).
  
  
  
  All tests yielded high diagnostic accuracy, with the ACE-III achieving the best diagnostic properties. The area under the curve was 0.897 for the ACE-III, 0.889 for the RUDAS, 0.874 for the MMSE, 0.866 for the MIS, and 0.856 for the MoCA. The Mini-ACE score from the ACE-III showed the highest diagnostic capacity (area under the curve 0.939). Memory scores of the ACE-III and of the RUDAS showed a better diagnostic accuracy than those of the MMSE and of the MoCA. All tests, especially the ACE-III, conveyed a higher diagnostic accuracy in patients with full primary education than in the less educated group. Implementing normative data improved the diagnostic accuracy of the ACE-III but not that of the other tests.
  
  
  
  The ACE-III achieved the highest diagnostic accuracy. This better discrimination was more evident in the more educated group.
authors.affiliation: Department of Neurology, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, Spain.
authors.forename: Jordi A
authors.initials: JA
authors.lastname: Matías-Guiu
authors.forename: María
authors.initials: M
authors.lastname: Valles-Salgado
authors.forename: Teresa
authors.initials: T
authors.lastname: Rognoni
authors.forename: Frank
authors.initials: F
authors.lastname: Hamre-Gil
authors.forename: Teresa
authors.initials: T
authors.lastname: Moreno-Ramos
authors.forename: Jorge
authors.initials: J
authors.lastname: Matías-Guiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D003430:Cross-Sectional Studies; D061827:Dimensional Measurement Accuracy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D011446:Prospective Studies; D015203:Reproducibility of Results
keywords: Addenbrooke’s Cognitive Examination; Alzheimer disease; Memory Impairment Screen; Mini-Mental State Examination; Montreal Cognitive Assessment; Neuropsychological assessment; Rowland Universal Dementia Assessment Scale; Screening