title: Metabolomics for biomarker discovery in the diagnosis, prognosis, survival and recurrence of colorectal cancer: a systematic review.
abstract: Colorectal cancer (CRC) remains an incurable disease. There are no effective noninvasive techniques that have achieved colorectal cancer (CRC) diagnosis, prognosis, survival and recurrence in clinic. To investigate colorectal cancer metabolism, we perform an electronic literature search, from 1998 to January 2016, for studies evaluating the metabolomic profile of patients with CRC regarding the diagnosis, recurrence, prognosis/survival, and systematically review the twenty-three literatures included. QUADOMICS tool was used to assess the quality of them. We highlighted the metabolism perturbations based on metabolites and pathway. Metabolites related to cellular respiration, carbohydrate, lipid, protein and nucleotide metabolism were significantly altered in CRC. Altered metabolites were also related to prognosis, survival and recurrence of CRC. This review could represent the most comprehensive information and summary about CRC metabolism to date. It certificates that metabolomics had great potential on both discovering clinical biomarkers and elucidating previously unknown mechanisms of CRC pathogenesis.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Kui
authors.initials: K
authors.lastname: Deng
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Zhuozhong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Libing
authors.initials: L
authors.lastname: Ma
authors.affiliation: Harbin Medical University, Harbin, P.R. China.
authors.forename: Margarita S
authors.initials: MS
authors.lastname: Openkova
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Harbin Medical University, Harbin, P.R. China.
authors.forename: Kang
authors.initials: K
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D055432:Metabolomics / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000378:metabolism; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor
keywords: CRC; biomarkers; metabolomics; pathway; systematic review