title: First four failures of cefathiamidine to treat urogenital gonorrhoea in Guangzhou, China, 2014-15.
abstract: Neisseria gonorrhoeae has a remarkable ability to develop resistance to all available therapeutic antimicrobials. This report describes the first four cases of verified failure to treat gonorrhoea using 1000mg cefathiamidine intramuscularly in Guangzhou, China; for each case, the patient was clinically cured after treatment with 500mg ceftriaxone intramuscularly. Enhanced monitoring of clinical treatment failures, finding new effective treatments and updating treatment guidelines are all of utmost importance to curb the spread of drug-resistant gonorrhoea.
authors.affiliation: Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, 56 Hengfu Road, Guangzhou 510095, China.
authors.forename: Jingyao
authors.initials: J
authors.lastname: Liang
authors.affiliation: Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, 56 Hengfu Road, Guangzhou 510095, China.
authors.forename: Ridong
authors.initials: R
authors.lastname: Yang
authors.affiliation: Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, 56 Hengfu Road, Guangzhou 510095, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, 56 Hengfu Road, Guangzhou 510095, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Bi
authors.affiliation: Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, 56 Hengfu Road, Guangzhou 510095, China.
authors.forename: Xingdong
authors.initials: X
authors.lastname: Ye
authors.affiliation: Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, 56 Hengfu Road, Guangzhou 510095, China.
authors.forename: Xibao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, 56 Hengfu Road, Guangzhou 510095, China.
authors.forename: Wenling
authors.initials: W
authors.lastname: Cao
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002681:China; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C018866:cefathiamidine