title: lncRNA-Encoded Polypeptide SPAR(s) with mTORC1 to Regulate Skeletal Muscle Regeneration.
abstract: Although prematurely baptized as non-coding, some lncRNAs encode polypeptides with regulatory functions that are implicated in various biological processes. Matsumoto et al. (2017) recently report in Nature that LINC00961 generates SPAR polypeptide that acts via the lysosome to suppress amino-acid-mediated mTORC1 activity, thereby modulating skeletal muscle regenerative response following injury.
authors.affiliation: Stem Cells and Development, Department of Developmental & Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 rue du Dr. Roux, 75015, Paris, France. Electronic address: shahragim.tajbakhsh@pasteur.fr.
authors.forename: Shahragim
authors.initials: S
authors.lastname: Tajbakhsh
mesh_terms: D018482:Muscle, Skeletal; D010455:Peptides; D062085:RNA, Long Noncoding; D012038:Regeneration
chemical_list: D010455:Peptides; D062085:RNA, Long Noncoding