title: Proteomics and irritable bowel syndrome.
abstract: Irritable bowel syndrome (IBS) is a gastrointestinal disease that according to Rome IV criteria is subdivided into four subtypes. The pathophysiology of this disease is not well understood due to numerous factors playing multiple roles in disease development, such as diet, stress and hormones. IBS has a variety of symptoms and overlaps with many other gastrointestinal and non-gastrointestinal diseases. Area covered: This review aims to present an overview of implementation of proteomics in experimental studies in the field of IBS. Expert commentary: Proteomics is commonly used for biomarker discovery in and has also been extensively used in IBS research. The necessity of a sensitive and specific biomarker for IBS is apparent, but despite the intensive research performed in this field, an appropriate biomarker is not yet available.
authors.affiliation: a Gastroenterology Unit , Evangelismos Hospital , Athens , Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Tsigaridas
authors.affiliation: b Hepatogastroenterology Unit, Second Department of Internal Medicine and Research Institute, Attikon University General Hospital, Medical School , National and Kapodistrian University of Athens , Athens , Greece.
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Papanikolaou
authors.affiliation: c Department of Basic Medical Sciences, Laboratory of Biology Medical School , National and Kapodistrian University of Athens , Athens , Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Vaiopoulou
authors.affiliation: d Proteomics Research Unit , Biomedical Research Foundation of the Academy of Athens (IIBEAA) , Athens , Greece.
authors.forename: Athanasios K
authors.initials: AK
authors.lastname: Anagnostopoulos
authors.affiliation: a Gastroenterology Unit , Evangelismos Hospital , Athens , Greece.
authors.forename: Nikos
authors.initials: N
authors.lastname: Viazis
authors.affiliation: e Gastroenterology Unit, 2nd Department of Surgery, 'Aretaieio' University Hospital, Medical School , National and Kapodistrian University of Athens , Athens , Greece.
authors.forename: George
authors.initials: G
authors.lastname: Karamanolis
authors.affiliation: a Gastroenterology Unit , Evangelismos Hospital , Athens , Greece.
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Karamanolis
authors.affiliation: d Proteomics Research Unit , Biomedical Research Foundation of the Academy of Athens (IIBEAA) , Athens , Greece.
authors.forename: George T
authors.initials: GT
authors.lastname: Tsangaris
authors.affiliation: a Gastroenterology Unit , Evangelismos Hospital , Athens , Greece.
authors.forename: Gerasimos J
authors.initials: GJ
authors.lastname: Mantzaris
authors.affiliation: c Department of Basic Medical Sciences, Laboratory of Biology Medical School , National and Kapodistrian University of Athens , Athens , Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Gazouli
mesh_terms: D015415:Biomarkers / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D020543:Proteome / Q000737:chemistry* / Q000378:metabolism; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: Genetics; IBS; biomarkers; pathophysiology; proteomics