title: Recent Developments and Challenges in Optimization-Based Process Synthesis.
abstract: This article first reviews recent developments in process synthesis and discusses some of the major challenges in the theory and practice in this area. Next, the article reviews key concepts in optimization-based conceptual design, namely superstructure representations, multilevel models, optimization methods, and modeling environments. A brief review of the synthesis of major subsystems and flowsheets is presented. Finally, the article closes with a critical assessment and future research challenges for the process synthesis area.
authors.affiliation: Center for Advanced Process Decision Making, Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; email: grossmann@cmu.edu.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Center for Advanced Process Decision Making, Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213; email: grossmann@cmu.edu.
authors.forename: I E
authors.initials: IE
authors.lastname: Grossmann
mesh_terms: D000465:Algorithms; D002616:Chemical Engineering / Q000295:instrumentation / Q000379:methods*; D060326:Chemistry Techniques, Synthetic / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D008956:Models, Chemical
keywords: conceptual design; distillation sequences; heat exchanger networks; mathematical programming; process flowsheets; process synthesis; reactor networks; superstructures