title: Near-infrared light-mediated DOX-UCNPs@mHTiO2nanocomposite for chemo/photodynamic therapy and imaging.
abstract: Recently, incorporating multiple components into one nanoplatform for anticancer theranostics has attracted most attention. Herein, a rattle-structured nanocomposite by using UCNPs (NaYF4:Yb,Tm@NaYF4) as core coated with hollow mesoporous TiO2(UCNPs@mHTiO2) was constructed as the nanocarrier. First, UCNPs@SiO2@TiO2was prepared, by a selective etching method to remove SiO2shell, to make sure the hollow mesoporous structure and high surface area (347m2g-1) of UCNPs@mHTiO2. Under near-infrared (NIR) light irradiation, the UV emission can excite TiO2to produce ROS and to realize photodynamic therapy (PDT). In addition, the hollow structure offers space to store antitumor drug molecules (doxorubicin, DOX) and this nanocomposite also exhibits the improved DOX release in mildly acidic environment, which could greatly promote chemotherapy efficiency. Moreover, the luminescence resonance energy transfer (LRET) from UCNPs to DOX, owing to the effective distance restricted by the cavity, can be used to monitor the intercellular drug release kinetics. HeLa cells were used as the model cancer cells and the detailed cell experiments show the enhanced cytotoxicity, ascribing to the synergistic effect of chemotherapy and PDT. Therefore, the novel multifunctional nanocomposite, combining with chemotherapy, PDT, and imaging, should be a potential candidate in anticancer field.
authors.affiliation: College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, PR China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Chen
authors.affiliation: College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, PR China. Electronic address: linhuiming@hrbnu.edu.cn.
authors.forename: Huiming
authors.initials: H
authors.lastname: Lin
authors.affiliation: College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, PR China.
authors.forename: Ruihan
authors.initials: R
authors.lastname: Tong
authors.affiliation: College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, PR China.
authors.forename: Na
authors.initials: N
authors.lastname: An
authors.affiliation: College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, PR China. Electronic address: qufengyu@hrbnu.edu.cn.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Qu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003952:Diagnostic Imaging / Q000379:methods*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers; D065546:Drug Liberation; D005459:Fluorides / Q000737:chemistry*; D006367:HeLa Cells / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007259:Infrared Rays; D007700:Kinetics; D053761:Nanocomposites / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010778:Photochemotherapy / Q000379:methods; D017382:Reactive Oxygen Species / Q000819:agonists; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology; D015019:Yttrium / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D017382:Reactive Oxygen Species; C525362:sodium yttriumtetrafluoride; C009495:titanium dioxide; D015019:Yttrium; D004317:Doxorubicin; D014025:Titanium; D005459:Fluorides
keywords: Chemotherapy; Hollow mesoporous structure; NIR; Photodynamic therapy; TiO(2); UCNPs