title: [Progress in research on meiotic genes underlying primary ovarian insuffiency].
abstract: Primary ovarian insuffiency (POI), which accounts for female infertility, is characterized by amenorrhea before the age of 40 and high serum level of follicular stimulating hormone (>40 U/L) at two measurements taken at least one month apart. The disorder is believed to have a strong genetic component. A large number of candidate genes have been proposed, though few of them were extensively studied. With the rapid evolvement of genome sequencing technology, recent research raised the possibility that the genes involved in essential steps of meiosis such as chromosome synapsis and recombination play an important role in the pathogenesis of POI. Clarifying the genetic pathogenesis of POI not only can enhance understanding of the molecular mechanism of reproductive functions and infertility, but also provide accurate information for genetic counseling for such patients.
authors.affiliation: Department of Medical Genetics, Molecular Diagnostic Laboratory, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. labwangjian@126.com.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000235:genetics; D008540:Meiosis; D016649:Primary Ovarian Insufficiency / Q000235:genetics* / Q000378:metabolism
chemical_list: D005640:Follicle Stimulating Hormone