title: Mycoplasma genitalium: a mycoplasma still underestimated.
abstract: Three men referred to the emergency department with suspected sexually transmitted infection like urethritis. After collection of several clinical specimens, they are sent home with a probabilistic treatment. Mycoplasma genitalium research is performed in first line, as Neisseria gonorrhoeae and Chlamydia trachomatis, and comes back positive. Patients are recalled in order to evaluate probabilistic treatment efficiency. M. genitalium, still underestimated because of its recent discovery, is responsible for 10 to 35% of non gonococcal acute and chronical urethritis. Its research is performed by PCR from urogenital specimens like genital swab or first void urine. Until recently, M. genitalium treatment included azithromycin 1g, antibiotic recommended in association with ceftriaxone in the probabilistic treatment of sexually transmitted infections. However, since the discovery of therapeutic failures and the emergence of resistance to azithromycin monodose, azithromycin in extended treatment (500 mg on the first day followed by 250 mg daily during 4 days) is now recommended as first-line agent when M. genitalium is well identified. A control by PCR is expected 4 or 5 weeks after treatment.
authors.affiliation: Laboratoire de biologie, Hôpital d'instruction des armées Bégin, Saint-Mandé, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Plantamura
authors.affiliation: Laboratoire de biologie, Hôpital d'instruction des armées Bégin, Saint-Mandé, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Bigaillon
authors.affiliation: Laboratoire de biologie, Hôpital d'instruction des armées Bégin, Saint-Mandé, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Bousquet
authors.affiliation: Laboratoire de biologie, Hôpital d'instruction des armées Bégin, Saint-Mandé, France.
authors.forename: Déborah
authors.initials: D
authors.lastname: Delaune
authors.affiliation: Laboratoire de biologie, Hôpital d'instruction des armées Bégin, Saint-Mandé, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Larréché
authors.affiliation: Laboratoire de biologie, Hôpital d'instruction des armées Percy, Clamart, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Bugier
authors.affiliation: Laboratoire de biologie, Hôpital d'instruction des armées Bégin, Saint-Mandé, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Mérens
authors.affiliation: Service de maladies infectieuses, Hôpital d'instruction des armées Bégin, Saint-Mandé, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Ficko
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D009175:Mycoplasma Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D045704:Mycoplasma genitalium / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D012749:Sexually Transmitted Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents
keywords: Mycoplasma genitalium; azithromycin; sexually transmitted infections; urethritis