title: iPS cell technologies and their prospect for bone regeneration and disease modeling: A mini review.
abstract: Bone disorders are a group of varied acute and chronic traumatic, degenerative, malignant or congenital conditions affecting the musculoskeletal system. They are prevalent in society and, with an ageing population, the incidence and impact on the population's health is growing. Severe persisting pain and limited mobility are the major symptoms of the disorder that impair the quality of life in affected patients. Current therapies only partially treat the disorders, offering management of symptoms, or temporary replacement with inert materials. However, during the last few years, the options for the treatment of bone disorders have greatly expanded, thanks to the advent of regenerative medicine. Skeletal cell-based regeneration medicine offers promising reparative therapies for patients. Mesenchymal stem (stromal) cells from different tissues have been gradually translated into clinical practice; however, there are a number of limitations. The introduction of reprogramming methods and the subsequent production of induced pluripotent stem cells provides a possibility to create human-specific models of bone disorders. Furthermore, human-induced pluripotent stem cell-based autologous transplantation is considered to be future breakthrough in the field of regenerative medicine. The main goal of the present paper is to review recent applications of induced pluripotent stem cells in bone disease modeling and to discuss possible future therapy options. The present article contributes to the dissemination of scientific and pre-clinical results between physicians, mainly orthopedist and thus supports the translation to clinical practice.
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia.
authors.forename: Maria
authors.initials: M
authors.lastname: Csobonyeiova
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia.
authors.forename: Stefan
authors.initials: S
authors.lastname: Polak
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Comenius University and Children's University Hospital, Limbova 1, 831 01 Bratislava, Slovakia.
authors.forename: Radoslav
authors.initials: R
authors.lastname: Zamborsky
authors.affiliation: Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia; Regenmed Ltd., Medena 29, 811 02 Bratislava, Slovakia.
authors.forename: Lubos
authors.initials: L
authors.lastname: Danisovic
keywords: Bone disorders; Disease modeling; Induced pluripotent stem cells; Regenerative medicine; Reprogramming