title: Integration of PET/MR Hybrid Imaging into Radiation Therapy Treatment.
abstract: Hybrid PET/MR imaging is in early development for treatment planning. This article briefly reviews research and clinical applications of PET/MR imaging in radiation oncology. With improvements in workflow, more specific tracers, and fast and robust acquisition protocols, PET/MR imaging will play an increasingly important role in better target delineation for treatment planning and have clear advantages in the evaluation of tumor response and in a better understanding of tumor heterogeneity. With advances in treatment delivery and the potential of integrating PET/MR imaging with research on radiomics for radiation oncology, quantitative and physiologic information could lead to more precise and personalized RT.
authors.affiliation: Department of Radiation Oncology, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27599, USA.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhu
authors.affiliation: Department of Radiation Oncology, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27599, USA.
authors.forename: Shiva
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27599, USA. Electronic address: terence_wong@med.unc.edu.
authors.forename: Terence Z
authors.initials: TZ
authors.lastname: Wong
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D009369:Neoplasms / Q000532:radiotherapy*; D049268:Positron-Emission Tomography / Q000379:methods*; D018787:Radiation Oncology / Q000379:methods; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*
keywords: Hybrid PET/MR imaging; MRI-based treatment planning; Normal tissue toxicity; PET tracers; Radiation therapy; Tumor heterogeneity; Tumor response