title: Outcomes in Children Born to Women with Rheumatic Diseases.
abstract: Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are the most prevalent autoimmune rheumatic diseases, predominantly occurring in women during childbearing years. Research has focused on assessing the risk of immediate complications during SLE and RA pregnancies, with studies documenting a higher risk of adverse obstetric outcomes, such as preterm births and infants small for gestational age. Until recently, little was known regarding the long-term health of children born to affected women. We present a review of the current evidence regarding the risk of adverse health outcomes in SLE and RA offspring, and potential mechanisms involved in their pathogenesis.
authors.affiliation: Division of Clinical Epidemiology, McGill University Health Centre, Pine Avenue, Montreal, Québec H3A 1A1, Canada; Division of Rheumatology, McGill University Health Centre, Cedar Avenue, Montreal, Québec H3G 1A4, Canada. Electronic address: evelyne.vinet@mcgill.ca.
authors.forename: Évelyne
authors.initials: É
authors.lastname: Vinet
authors.affiliation: Division of Clinical Epidemiology, McGill University Health Centre, Pine Avenue, Montreal, Québec H3A 1A1, Canada; Division of Rheumatology, McGill University Health Centre, Cedar Avenue, Montreal, Québec H3G 1A4, Canada.
authors.forename: Sasha
authors.initials: S
authors.lastname: Bernatsky
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000453:epidemiology*; D002648:Child; D016207:Cytokines / Q000276:immunology; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D065886:Neurodevelopmental Disorders / Q000453:epidemiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000276:immunology; D012216:Rheumatic Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology
chemical_list: D018501:Antirheumatic Agents; D001323:Autoantibodies; D016207:Cytokines
keywords: Children; Long-term outcomes; Pregnancy; Rheumatoid arthritis; Systemic lupus erythematosus