title: Diet-derived changes by sourdough-fermented rye bread in exhaled breath aspiration ion mobility spectrometry profiles in individuals with mild gastrointestinal symptoms.
abstract: The potential of utilising exhaled breath volatile organic compound (VOC) profiles in studying diet-derived metabolic changes was examined. After a four-week initial diet period with white wheat bread (WW), seven participants received in randomised order high-fibre diets containing sourdough whole grain rye bread (WGR) or white wheat bread enriched with bioprocessed rye bran (WW + BRB), both for 4 weeks. Alveolar exhaled breath samples were analysed with ChemPro®100i analyser (Environics OY, Mikkeli, Finland) at the end of each diet period in fasting state and after a standardised meal. The AIMS signal intensities in fasting state were different after the WGR diet as compared to other diets. The result suggests that WGR has metabolic effects not completely explained by the rye fibre content of the diet. This study encourages to utilise the exhaled breath VOC profile analysis as an early screening tool in studying physiological functionality of foods.
authors.affiliation: a Institute of Public Health and Clinical Nutrition, Ita-Suomen Yliopisto Kuopion Kampus , Kuopio, Finland.
authors.forename: Kaisa
authors.initials: K
authors.lastname: Raninen
authors.affiliation: a Institute of Public Health and Clinical Nutrition, Ita-Suomen Yliopisto Kuopion Kampus , Kuopio, Finland.
authors.forename: Jenni
authors.initials: J
authors.lastname: Lappi
authors.affiliation: b Department of Environmental and Biological Sciences , University of Eastern Finland , Kuopio, Finland.
authors.forename: Mikko
authors.initials: M
authors.lastname: Kolehmainen
authors.affiliation: a Institute of Public Health and Clinical Nutrition, Ita-Suomen Yliopisto Kuopion Kampus , Kuopio, Finland.
authors.forename: Marjukka
authors.initials: M
authors.lastname: Kolehmainen
authors.affiliation: a Institute of Public Health and Clinical Nutrition, Ita-Suomen Yliopisto Kuopion Kampus , Kuopio, Finland.
authors.forename: Hannu
authors.initials: H
authors.lastname: Mykkänen
authors.affiliation: c VTT Technical Research Centre of Finland , Espoo, Finland.
authors.forename: Kaisa
authors.initials: K
authors.lastname: Poutanen
authors.affiliation: a Institute of Public Health and Clinical Nutrition, Ita-Suomen Yliopisto Kuopion Kampus , Kuopio, Finland.
authors.forename: Olavi
authors.initials: O
authors.lastname: Raatikainen
mesh_terms: D000328:Adult; D001939:Bread / Q000145:classification*; D001944:Breath Tests; D004032:Diet; D004043:Dietary Fiber / Q000378:metabolism; D005260:Female; D005285:Fermentation; D005767:Gastrointestinal Diseases / Q000178:diet therapy*; D006801:Humans; D000075663:Ion Mobility Spectrometry / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012434:Secale / Q000737:chemistry
chemical_list: D004043:Dietary Fiber
keywords: Exhaled breath; VOC profile; aspiration ion mobility spectrometry; diet; rye