title: Matrix metalloproteases expression in different histological types of colorectal polyps.
abstract: BACKGROUND
  Colorectal carcinoma (CC) may begin as benign polyps, which may be classified in different histological types with a different risk to develop cancer. Matrix metalloproteases (MMPs) are able to degrade all components in the extracellular matrix and are important tissue-remodeling enzymes and key elements in tumor invasion and metastasis. The aim of this study was to investigate the expression and clinical relevance of MMPs in different histological types of colorectal polyps.
  
  
  METHODS
  The expression levels of MMP-1, 2, 7, 9, 11, 13 and 14 were analyzed by real-time PCR, Western-blot and immunohistochemistry in 50 patients with different histological types of colorectal polyps, 28 of which developed CC.
  
  
  RESULTS
  The results indicate that hyperplastic polyps had the lowest levels of MMP-1 and MMP-7, tubular polyps showed higher levels of both MMP-7 and MMP-14, and tubulovillous adenoma showed higher levels of MMP-1, MMP-7 and MMP-14.
  
  
  CONCLUSIONS
  MMP expression was decreased in hyperplastic, tubular and tubulovillous adenoma polyps from patients who developed CC. Our findings suggest that MMP expression may be a pathological marker of colorectal polyps and for cancer susceptibility, which may improve strategies for CC prevention based on screening colonoscopy.
authors.affiliation: Unidad de Investigación, Fundación Hospital de Jove.
authors.forename: Noemi
authors.initials: N
authors.lastname: Eiró
authors.affiliation: Unidad de Investigación y Servicio de Anatomía Pat, Fundación Hospital de Jove.
authors.forename: Luis O
authors.initials: LO
authors.lastname: González
authors.affiliation: Unidad de Investigación, Fundación Hospital de Jove.
authors.forename: Sandra
authors.initials: S
authors.lastname: Cid
authors.affiliation: Unidad de Investigación y Servicio de Cirugía Gene, Fundación Hospital de Jove.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Andicoechea
authors.affiliation: Unidad de Investigación y Servicio de Cirugía Gene, Fundación Hospital de Jove, España.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Vizoso
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D003111:Colonic Polyps / Q000201:enzymology* / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D006801:Humans; D008297:Male; D020782:Matrix Metalloproteinases / Q000096:biosynthesis* / Q000235:genetics*; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; D020782:Matrix Metalloproteinases