title: Bilateral Triple-Negative Invasive Breast Cancer with aBRCA2Mutation, and Glioblastoma: A Case Report and Literature Review.
abstract: Breast cancer is the second leading cause of death among women in North America. Glioblastoma is the most common primary malignant central nervous system tumor in adults. The majority of hereditary breast cancers are associated with deleterious mutations in theBRCA1andBRCA2genes. Although few case reports have described the incidence of glioblastoma in patients previously diagnosed with breast cancer, any association betweenBRCA2mutations and glioblastoma has not been demonstrated to date. Herein, we report a woman who is a carrier of a familialBRCA2mutation, and was previously diagnosed with triple-negative breast cancer (TNBC) and subsequently with a second primary TNBC and glioblastoma. Further investigation is required to define the possible relationship between these two aggressive malignances and theBRCA2mutation, which might be critical for the proper management and treatment of this disease.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Joan C. Edwards School of Medicine at Marshall University/Edward Comprehensive Care Center, Huntington, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Raufi
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Joan C. Edwards School of Medicine at Marshall University/Edward Comprehensive Care Center, Huntington, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Alsharedi
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Joan C. Edwards School of Medicine at Marshall University/Edward Comprehensive Care Center, Huntington, USA.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Khelfa
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Joan C. Edwards School of Medicine at Marshall University/Edward Comprehensive Care Center, Huntington, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Tirona
keywords: BRCA2 genes; Glioblastoma; Triple-negative breast neoplasms