title: An Updated Review of Cribriform Carcinomas with Emphasis on Histopathological Diagnosis and Prognostic Significance.
abstract: Cribriform is a histopathological term used to describe a neoplastic epithelial proliferation in the form of large nests perforated by many quite rounded different-sized spaces. This growth pattern may be seen in carcinomas arising in different organs, and shows important prognostic implications. Therefore, recent data in literature suggest that cribriform carcinoma is a histologically and clinically distinctive type of tumour that should be separated from other similar tumour types. In this article, the pathology of cribriform adenocarcinoma of the prostate, lung, breast, stomach, colon, thyroid, and skin is discussed with particular reference to morphologic and immunohistochemical features, differential diagnosis, and clinical behaviour.
authors.affiliation: Department of Human Pathology G. Barresi, University of Messina , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Branca
authors.affiliation: Department of Human Pathology G. Barresi, University of Messina , Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ieni
authors.affiliation: Department of Human Pathology G. Barresi, University of Messina , Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Barresi
authors.affiliation: Department of Human Pathology G. Barresi, University of Messina , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tuccari
authors.affiliation: Department of Human Pathology G. Barresi, University of Messina , Italy.
authors.forename: Rosario Alberto
authors.initials: RA
authors.lastname: Caruso
keywords: Cribriform carcinoma; differential diagnosis; histopathology; immunohistochemistry; prognosis