title: Efficacy of Hearing Aids on the Cognitive Status of Patients with Alzheimer's Disease and Hearing Loss: A Multicenter Controlled Randomized Trial.
abstract: This study evaluated the cognitive benefit of hearing aids (HA) in older patients with Alzheimer's disease (AD) and hearing loss (HL) after a 6- and 12-month period of utilization.
  
  
  
  A multicenter double-blind randomized placebo-controlled trial was conducted in patients aged more than 65 years. A group was equipped with active HA for 6 months (active group) and a second group had placebo HA for 6 months (placebo group) followed by a secondary activation phase for a further 6 months (semi crossover procedure). Both groups were retested after a 12-month period. The primary endpoint was the change from baseline of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS Cog) after a 6-month period in both groups and after 6 months of secondary HA activation in the placebo group. A smaller cognitive decline should be obtained with HA use; an increase in ADAS Cog score of less than 6 points was defined a success.
  
  
  
  Fifty-one patients aged 68 to 99 years were included; 38 attended the 6-month visit: 18 in the active group and 20 in the placebo group. At 6 months, 14 (82.4%) successes were noticed in the active group, and 15 (88.2%) in the placebo group (p = 1.0); delta ADAS Cog in the active group was 1.8±5.3 and 1.3±5.3 in the placebo group (p = 0.8). In the placebo group, after the secondary HA activation, no significant improvement was observed.
  
  
  
  No significant effect of HA use was observed after 6 months of follow-up in patients with AD and HL.
authors.affiliation: Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre Bénite, France.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Nguyen
authors.affiliation: Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre Bénite, France.|University Claude Bernard Lyon 1, Faculty of Medicine Lyon Sud, Pierre Bénite, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Bonnefoy
authors.affiliation: Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre Bénite, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Adrait
authors.affiliation: Clinical Research Unit, Pole IMER, Hospices Civils de Lyon, Lyon, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Gueugnon
authors.affiliation: Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre Bénite, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Petitot
authors.affiliation: Department of Audiology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Collet
authors.affiliation: Clinical Research Unit, Pole IMER, Hospices Civils de Lyon, Lyon, France.
authors.forename: Adeline
authors.initials: A
authors.lastname: Roux
authors.affiliation: University Claude Bernard Lyon 1, Faculty of Medicine Lyon Sud, Pierre Bénite, France.|Department of Audiology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.|Institute of Sciences and Techniques for Rehabilitation (ISTR), Lyon 1 University, University of Lyon, Lyon, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Perrot
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000534:rehabilitation; D001299:Audiometry; D003072:Cognition Disorders / Q000209:etiology* / Q000534:rehabilitation; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006310:Hearing Aids; D034381:Hearing Loss / Q000150:complications* / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests
keywords: Alzheimer’s disease; hearing aids; hearing loss; non-pharmacological treatment; randomized controlledclinical trial