title: PostoperativeHelicobacter pyloriInfection as a Prognostic Factor for Gastric Cancer Patients after Curative Resection.
abstract: OBJECTIVE
  Few studies have evaluated the effect ofHelicobacter pyloriinfection on the prognosis of patients diagnosed with gastric cancer (GC) after curative surgery. We investigated the association between theH. pyloriinfection status and clinical outcome after surgery.
  
  
  METHODS
  We assessed theH. pyloristatus of 314 patients who underwent curative resection for GC. TheH. pyloristatus was examined using a rapid urease test 2 months after resection. Patients were followed for 10 years after surgery.
  
  
  RESULTS
  AnH. pyloriinfection was observed in 128 of 314 patients. The median follow-up period was 93.5 months. A Kaplan-Meier analysis indicated that patients withH. pylorihad a higher cumulative survival rate than those who were negative forH. pylori. Patients with stage II cancer who tested negative forH. pyloriwere associated with a poor outcome. In a multivariate analysis,H. pylori-negative status was a significant independent prognostic factor for poor overall survival.
  
  
  CONCLUSIONS
  Having a negativeH. pyloriinfection status seems to indicate poor prognosis for patients with GC who have undergone curative resection. Further prospective controlled studies are needed to evaluate the mechanism by whichH. pyloriaffects GC patients after curative surgery in Korea.
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Da Hyun
authors.initials: DH
authors.lastname: Jung
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Yong Chan
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jie-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyunsoo
authors.initials: H
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jun Chul
authors.initials: JC
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sung Kwan
authors.initials: SK
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sang Kil
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyoung-Il
authors.initials: HI
authors.lastname: Kim
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Hyung
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Noh
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005773:Gastroscopy / Q000401:mortality*; D016481:Helicobacter Infections / Q000382:microbiology / Q000401:mortality*; D016480:Helicobacter pylori; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000382:microbiology / Q000401:mortality*; D011379:Prognosis; D056910:Republic of Korea; D013274:Stomach Neoplasms / Q000401:mortality* / Q000601:surgery; D015996:Survival Rate
keywords: General surgery; Helicobacter pylori; Prognosis; Stomach neoplasms