title: Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity.
abstract: Although acute myeloid leukaemia (AML) is assumed to be driven by transformed haematopoietic stem and progenitor cells, we have described recently a new pathway leading to AML from T-cell progenitors. Furthermore, we could identify a subgroup of human AML with gene expression profile suggesting T-lymphoid origin and potentially novel treatment.
authors.affiliation: Institute of Molecular Tumor Biology, University of Münster , Münster, Germany.
authors.forename: Melinda
authors.initials: M
authors.lastname: Czeh
authors.affiliation: Institute of Molecular Tumor Biology, University of Münster , Münster, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Rosenbauer
keywords: Leukemia; T-cell progenitors; lineage plasticity; myeloid differentiation