title: Redox-Neutral Dual Functionalization of Electron-Deficient Alkenes.
abstract: Visible-light photoredox catalysis has been utilized in a new multicomponent reaction forming β-functionalized δ-diketones under mild conditions in an operationally convenient manner. Single-electron reduction of in situ generated carboxylic acid derivatives forms acyl radicals that react further via 1,2-acylalkylation of olefins in an intermolecular, three-components cascade reaction, giving valuable synthetic entities from readily available starting materials. A diverse set of substrates has been used, demonstrating robust methodology with broad substrate scope.
authors.affiliation: Department of Chemistry and Molecular Biology, Gothenburg University, 41296, Gothenburg, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Pettersson
authors.affiliation: Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Pepparedsleden 1, 43183, Mölndal, Sweden.
authors.forename: Giulia
authors.initials: G
authors.lastname: Bergonzini
authors.affiliation: Department of Chemistry and Molecular Biology, Gothenburg University, 41296, Gothenburg, Sweden.
authors.forename: Carlo
authors.initials: C
authors.lastname: Cassani
authors.affiliation: Department of Chemistry and Molecular Biology, Gothenburg University, 41296, Gothenburg, Sweden.
authors.forename: Carl-Johan
authors.identifier: http://orcid.org/0000-0003-1983-9378
authors.initials: CJ
authors.lastname: Wallentin
keywords: acyl radicals; carboxylic acids; cascade transformation; multicomponent reactions; photoredox catalysis