title: A new phthalide from the endophytic fungus Xylaria sp. GDG-102.
abstract: A new phthalide derivative, xylarphthalide A (1), along with two known compounds (-)-5-carboxylmellein (2) and (-)-5-methylmellein (3), were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from the Chinese medicinal plant Sophora tonkinensis. Their structures were identified by MS and NMR experiments, and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compound 1-3 showed antibacterial activities against Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Shigella dysenteriae with MIC values of 12.5-25 μg/mL.
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Zheng
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Feihua
authors.initials: F
authors.lastname: Yao
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Liang
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Liu
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Weifeng
authors.initials: W
authors.lastname: Xu
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Liu
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: a State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources , College of Chemistry and Pharmaceutical Sciences, Guangxi Normal University , Guilin , P.R. China.
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Yang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001572:Benzofurans / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D060026:Endophytes / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000382:microbiology; D029909:Sophora / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013098:Xylariales / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans
keywords: Xylaria sp.; antibacterial activity; endophytic fungus; phthalide