title: [Modern view on etiology, pathogenesis and treatment of chronic pelvic pain syndrome].
abstract: The manuscript presents the analysis of scientific manuscripts written by Russian and foreign researchers devoted to chronic pelvic pain syndrome (CPPS) studies. In spite of widespread disease, there is no clear understanding on etiopathogenetic mechanisms of CPPS development and it is shown that besides infectious process cardiovascular, neuronal, locomotor, endocrine and immune systems are involved into pathological process of CPPS. Mentioned factors complicate the doctors task on effective therapy choice and stress the reasonability of complex approach to CPPS treatment. Combination drug containing affinity purified antibodies to endothelial NO-synthase and prostate-specific antigen in released-active form influences different pathogenetic mechanisms of CPPS and thereby reveals pronounced clinical efficacy.
authors.affiliation: Urology department of I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Vinarov
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000906:Antibodies / Q000627:therapeutic use; D002908:Chronic Disease; D004338:Drug Combinations; D006801:Humans; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000276:immunology; D017699:Pelvic Pain / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D017430:Prostate-Specific Antigen / Q000276:immunology; D011472:Prostatitis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D013577:Syndrome
chemical_list: D000317:Adrenergic alpha-Antagonists; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000906:Antibodies; D004338:Drug Combinations; D052250:Nitric Oxide Synthase Type III; D017430:Prostate-Specific Antigen
keywords: antibodies to endothelial NO-synthase in released-active form; antibodies to prostate-specific antigen in released-active form; chronic pelvic pain syndrome