title: [Clinical significance of hypersensitive C-reactive protein, fribrinogen and D-dimmer in connective tissue disease-related interstitial lung disease].
abstract: OBJECTIVE
  To investigate the clinical significance of plasma levels of hypersensitive C-reactive protein (hs-CRP), fibriogen and D-dimmer (D-DI) in patients with connective tissue disease (CTD)-related interstitial lung disease (CTD-ILD).
  
  
  METHODS
  Sixty-nine patients with interstitial lung disease admitted in Zhujiang Hospital between January, 2010 and April, 2016, including 29 with CTD-ILD and 40 with non-CTD-ILD were analyzed for plasma levels of hs-CRP, fibriogen and D-DI, with 25 healthy subjects as the control group.
  
  
  RESULTS
  The plasma level of hs-CRP, fibriogen and D-DI in patients with CTD-ILD and non-CTD-ILD were all significantly higher than those in the control group. The patients with CTD-ILD had a significantly higher hs-CRP level than those with non-CTD-ILD, but the levels of fibriogen and D-DI were comparable between the two groups. Correlation analysis indicated that Hs-CRP level was positively correlated with the levels of D-DI (r=0.539, P<0.01) and fibrinogen (r=0.534, P<0.01).
  
  
  CONCLUSIONS
  Hs-CRP, fibriogen and D-DI levels show an important value in clinical diagnosis of CTD, and an obvious elevation of hs-CRP is correlated with the CTD.
authors.affiliation: Department of Respiratory, Zhujiang Hospital , Southern Medical University, Guangzhou 510282, China.E-mail: 269665687@qq.com.
authors.forename: Si-Jie
authors.initials: SJ
authors.lastname: Yuan
authors.forename: Hai-Ting
authors.initials: HT
authors.lastname: Xie
authors.forename: Zhong-Li
authors.initials: ZL
authors.lastname: Li
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003240:Connective Tissue Diseases / Q000097:blood*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005340:Fibrinogen; D002097:C-Reactive Protein