title: Diagnosis in vascular dementia, applying 'Cochrane diagnosis rules' to 'dementia diagnostic tools'.
abstract: In this issue ofClinical Science, Biesbroek and colleagues describe recent work on magnetic resonance imaging (MRI)-based cerebral lesion location and its association with cognitive decline. The authors conclude that diagnostic neuroimaging in dementia should shift from whole-brain evaluation to focused quantitative analysis of strategic brain areas. This commentary uses the review of lesion location mapping to discuss broader issues around studies of dementia test strategies. We draw upon work completed by the Cochrane Dementia and Cognitive Improvement Group designed to improve design, conduct and reporting of dementia biomarker studies.
authors.affiliation: Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K. terry.quinn@glasgow.ac.uk.
authors.forename: Terence J
authors.initials: TJ
authors.lastname: Quinn
authors.affiliation: Cochrane Dementia and Cognitive Improvement Group, Cochrane, Oxford, U.K.
authors.forename: Jenny
authors.initials: J
authors.lastname: McCleery
mesh_terms: D015415:Biomarkers; D001921:Brain; D003704:Dementia; D015140:Dementia, Vascular; D006801:Humans; D008279:Magnetic Resonance Imaging; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers
keywords: biomarkers; dementia; sensitivity/specificity; test accuracy; vascular cognitive impairment