title: Targeting Rabs as a novel therapeutic strategy for cancer therapy.
abstract: Rab GTPases constitute the largest family of small GTPases. Rabs regulate not only membrane trafficking but also cell signaling, growth and survival, and development. Increasingly, Rabs and their effectors are shown to be overexpressed or subject to loss-of-function mutations in a variety of disease settings, including cancer progression. This review provides an overview of dysregulated Rab proteins in cancer, and highlights the signaling and secretory pathways in which they operate, with the aim of identifying potential avenues for therapeutic intervention. Recent progress and perspectives for direct and/or indirect targeting of Rabs are also summarized.
authors.affiliation: Oncology Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Qin
authors.affiliation: Oncology Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China.
authors.forename: Jiongyi
authors.initials: J
authors.lastname: Wang
authors.affiliation: Oncology Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Oncology Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Oncology Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China. Electronic address: jiangbinwcr@sjtu.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Oncology Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China. Electronic address: zhangyanjie@shsmu.edu.cn.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction; D020691:rab GTP-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D020691:rab GTP-Binding Proteins