title: N-Trifluoromethylation of Nitrosoarenes with Sodium Triflinate.
abstract: A highly efficient N-trifluoromethylation of nitrosoarenes is reported. The inexpensive and convenient Langlois reagent (sodium triflinate) is employed as a CF3-radical source in combination with a copper catalyst and an oxidant. N-Trifluoromethylated hydroxylamines are obtained in high yields within 1 h at room temperature. The addition of hydroquinone was found to be instrumental to prevent the formation of side products. The method is high-yielding, is scalable, and displays a high functional group tolerance.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, Sweden.
authors.forename: Angela
authors.identifier: 0000-0001-6517-8879
authors.initials: A
authors.lastname: van der Werf
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, Sweden.
authors.forename: Matic
authors.identifier: 0000-0002-7826-9953
authors.initials: M
authors.lastname: Hribersek
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University , SE-106 91 Stockholm, Sweden.
authors.forename: Nicklas
authors.identifier: 0000-0002-9085-0476
authors.initials: N
authors.lastname: Selander