title: Long-Term Outcomes of 560 Consecutive Patients Treated With Transcatheter Aortic Valve Implantation and Propensity Score-Matched Analysis of Early- Versus New-Generation Valves.
abstract: Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis in patients at high or prohibitive surgical risk. Nevertheless, long-term clinical and echocardiographic data are still lacking. We carried out an analysis of 560 consecutive patients who underwent TAVI at our institution from 2008 to 2016 to evaluate temporal changes in TAVI characteristics, predictors of 1-year and long-term outcomes, and to compare the performance of the early- and new-generation valve systems. With time, we have adopted lower risk threshold for patient selection and have been using conscious sedation and transfemoral access preferentially (p <0.001 for all). The incidence of greater than mild PVL decreased from 16% to 7.6%, p = 0.029. Within 5 years, 47% of the patients died, the majority (78%) due to noncardiac causes. Independent predictors of 1-year death included periprocedural aspects (i.e., vascular complications, stroke, and PVL), whereas death occurring later than 1 year was solely related to baseline co-morbidities. Transvalvular gradients and residual regurgitation remained nonclinically significant for up to 5 years of follow-up. New-generation valves were associated with less PVL compared with propensity score-matched early-generation valves (p <0.001). In conclusion, TAVI utilization at our institution has progressed to include lower risk patients with transfemoral access becoming applicable in the great majority. Poor long-term survival is attributable to population factors rather than to procedural factors. Intermediate- and long-term hemodynamics are excellent. PVL has diminished significantly with the new-generation valves. Efforts to improve long- and short-term outcomes remain a therapeutic challenge.
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Amos
authors.initials: A
authors.lastname: Levi
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Uri
authors.initials: U
authors.lastname: Landes
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Abid R
authors.initials: AR
authors.lastname: Assali
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Katia
authors.initials: K
authors.lastname: Orvin
authors.affiliation: "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Cardiothoracic Surgery, "Rabin Medical Center," Petah Tikva, Israel.
authors.forename: Ram
authors.initials: R
authors.lastname: Sharony
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Hanna
authors.initials: H
authors.lastname: Vaknin-Assa
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Hamdan
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Shapira
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Schwartzenberg
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; Department of Cardiothoracic Surgery, "Rabin Medical Center," Petah Tikva, Israel.
authors.forename: Pablo
authors.initials: P
authors.lastname: Codner
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Aviv A
authors.initials: AA
authors.lastname: Shaul
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Mordechai
authors.initials: M
authors.lastname: Vaturi
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ariel
authors.initials: A
authors.lastname: Gutstein
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Alexander
authors.initials: A
authors.lastname: Sagie
authors.affiliation: Cardiology Department, "Rabin Medical Center," Petah Tikva, Israel; "Sackler" School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: ran.kornowski@gmail.com.
authors.forename: Ran
authors.initials: R
authors.lastname: Kornowski
mesh_terms: D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000601:surgery*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D061330:Multidetector Computed Tomography; D011183:Postoperative Complications / Q000453:epidemiology*; D057216:Propensity Score; D011474:Prosthesis Design; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods*; D016896:Treatment Outcome