title: Multidrug ResistantPseudomonasMycotic Pseudoaneurysm following Cardiac Transplant Bridged by Ventricular Assistant Device.
abstract: Mycotic pseudoaneurysm of aorta following cardiac surgery is rare but is highly fatal if it is unrecognized and untreated. Here, we report a case of a 45-year-old male patient who presented with rapidly progressive multiple pseudoaneurysms of the ascending aorta infected with multidrug resistant (MDR)Pseudomonas aeruginosa at5 weeks after cardiac transplantation, on a background of prior bridging therapy with left ventricular assistant device (LVAD). The patient was successfully treated with the newer cephalosporin, Ceftolozane/Tazobactam, in combination with surgery. This is the first reported case of mycotic pseudoaneurysm infected with MDRPseudomonas. This case also highlights the importance of high vigilance and timely multimodality treatment in the diagnosis and management of mycotic pseudoaneurysm following cardiac transplant, especially in patients who had LVAD.
authors.affiliation: Infection Management Unit, The Prince Charles Hospital, Brisbane, QLD 4032, Australia; School of Medicine, University of Queensland, Brisbane, QLD, Australia.
authors.forename: C
authors.identifier: 0000-0002-5443-7000
authors.initials: C
authors.lastname: Aye
authors.affiliation: Department of Pharmacy, The Prince Charles Hospital, Brisbane, QLD 4032, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.affiliation: Infection Management Unit, The Prince Charles Hospital, Brisbane, QLD 4032, Australia; School of Medicine, University of Queensland, Brisbane, QLD, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Horvath