title: A new p-hydroxybenzoic acid derivative from an endophytic fungus Penicillium sp. of Nerium indicum.
abstract: A new p-hydroxybenzoic acid derivative named 4-(2'R, 4'-dihydroxybutoxy) benzoic acid (1) was isolated from the fermentation of Penicillium sp. R22 in Nerium indicum. The structure was elucidated by means of spectroscopic (HR-ESI-MS, NMR, IR, UV) and X-ray crystallographic methods. The antibacterial and antifungal activity of compound 1 was tested, and the results showed that compound 1 revealed potent antifungal activity against Colletotrichum gloeosporioides, Alternaria alternata, and Alteranria brassicae with MIC value of 31.2 μg/ml.
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry , Ministry of Education, Shaanxi University of Science and Technology , Xi'an 710021 , China.
authors.forename: Yang-Min
authors.initials: YM
authors.lastname: Ma
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry , Ministry of Education, Shaanxi University of Science and Technology , Xi'an 710021 , China.
authors.forename: Ke
authors.initials: K
authors.lastname: Qiao
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry , Ministry of Education, Shaanxi University of Science and Technology , Xi'an 710021 , China.|b School of Food and Biological Engineering , Shaanxi University of Science and Technology , Xi'an 710021 , China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Kong
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry , Ministry of Education, Shaanxi University of Science and Technology , Xi'an 710021 , China.
authors.forename: Lin-Xin
authors.initials: LX
authors.lastname: Guo
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry , Ministry of Education, Shaanxi University of Science and Technology , Xi'an 710021 , China.
authors.forename: Meng-Yun
authors.initials: MY
authors.lastname: Li
authors.affiliation: a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry , Ministry of Education, Shaanxi University of Science and Technology , Xi'an 710021 , China.
authors.forename: Chao
authors.initials: C
authors.lastname: Fan
mesh_terms: D000528:Alternaria; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020231:Colletotrichum; D005285:Fermentation; D062385:Hydroxybenzoates / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D030007:Nerium / Q000382:microbiology*; D010407:Penicillium / Q000737:chemistry*
chemical_list: C000625273:4-(2'R,4'-dihydroxybutoxy)benzoic acid; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001565:Benzoates; D062385:Hydroxybenzoates
keywords: 4-(2′R, 4′-dihydroxybutoxy) benzoic acid; Endophytic fungi; Penicillium sp; antimicrobial activity