title: Analysis on regulatory network linked to Hpa gene in invasion and metastasis of colon cancer.
abstract: Our purpose was to discuss the biological function of Hpa gene and its regulatory network in invasion and metastasis of colon cancer. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes database were used to perform functional annotation and pathway analysis on Hpa gene. Gene Ontology analysis results showed that Hpa plays a significant role in cellular component, molecular function and biological process; and combined with Kyoto Encyclopedia of Genes and Genomes database, regulatory network of angiogenesis of colon cancer was drawn out. Through analysis of regulatory network linked to angiogenesis in invasion and metastasis of colon cancer, the study lays foundation for further prevention, diagnosis and treatment of colon cancer.
authors.affiliation: Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No.195, Tongbai Road, Zhongyuan District, Zhengzhou, Henan Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No.195, Tongbai Road, Zhongyuan District, Zhengzhou, Henan Province, China.
authors.forename: Huili
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No.195, Tongbai Road, Zhongyuan District, Zhengzhou, Henan Province, China.
authors.forename: Xingguo
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No.195, Tongbai Road, Zhongyuan District, Zhengzhou, Henan Province, China.
authors.forename: Kunkun
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No.195, Tongbai Road, Zhongyuan District, Zhengzhou, Henan Province, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No.195, Tongbai Road, Zhongyuan District, Zhengzhou, Henan Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No.195, Tongbai Road, Zhongyuan District, Zhengzhou, Henan Province, China.
authors.forename: Tingyu
authors.initials: T
authors.lastname: Wen
keywords: Angiogenesis; GO analysis; Hpa gene; Invasion and metastasis of colon cancer; Network pathway