title: Polymer Dots for Photoelectrochemical Bioanalysis.
abstract: Different from the most extensively used inorganic quantum dots (Qdots) for the current state-of-the-art photoelectrochemical (PEC) bioanalysis, this work reports the first demonstration of polymer dots (Pdots) for novel PEC bioanalysis. The semiconducting Pdots were prepared via the reprecipitation method and then immobilized onto the transparent indium tin oxide glass electrode for PEC biodetection of the model molecule l-cysteine. The experimental results revealed that the as-fabricated Pdots exhibited excellent and interesting PEC activity and good analytical performance of rapid response, high stability, wide linear range, and excellent selectivity. In particular, the PEC sensor could easily discriminate l-cysteine from reduced l-glutathione (l-GSH). This work manifested the great promise of Pdots in the field of PEC bioanalysis, and it is believed that our work could inspire the development of numerous functional Pdots with unique properties for innovative PEC bioanalytical purposes in the future.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, Jiangsu 210023, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, Jiangsu 210023, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, Jiangsu 210023, China.
authors.forename: Wei-Wei
authors.identifier: 0000-0002-8179-4775
authors.initials: WW
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, Jiangsu 210023, China.
authors.forename: De-Chen
authors.identifier: 0000-0002-2845-3621
authors.initials: DC
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, Jiangsu 210023, China.
authors.forename: Jing-Juan
authors.identifier: 0000-0001-9579-9318
authors.initials: JJ
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, Jiangsu 210023, China.
authors.forename: Hong-Yuan
authors.initials: HY
authors.lastname: Chen
mesh_terms: D003545:Cysteine / Q000032:analysis; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods; D005449:Fluorenes / Q000737:chemistry / Q000528:radiation effects; D008027:Light; D008298:Maleates / Q000737:chemistry / Q000528:radiation effects; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D010777:Photochemistry / Q000295:instrumentation* / Q000379:methods; D017319:Photosensitizing Agents / Q000737:chemistry / Q000528:radiation effects; D011108:Polymers / Q000737:chemistry* / Q000528:radiation effects; D011137:Polystyrenes / Q000737:chemistry / Q000528:radiation effects; D011166:Porphyrins / Q000737:chemistry / Q000528:radiation effects
chemical_list: C509964:5,10,15,20-tetraphenylporphyrin; D005449:Fluorenes; D008298:Maleates; D017319:Photosensitizing Agents; D011108:Polymers; D011137:Polystyrenes; D011166:Porphyrins; C556103:poly((9,9-dioctylfluorenyl-2,7-diyl)-co-(1,4-benzo-(2,1',3)-thiadiazole)); C521900:poly(styrene-co-maleic anhydride); D003545:Cysteine