title: Emerging infectious diseases: A proactive approach.
abstract: Infectious diseases are now emerging or reemerging almost every year. This trend will continue because a number of factors, including the increased global population, aging, travel, urbanization, and climate change, favor the emergence, evolution, and spread of new pathogens. The approach used so far for emerging infectious diseases (EIDs) does not work from the technical point of view, and it is not sustainable. However, the advent of platform technologies offers vaccine manufacturers an opportunity to develop new vaccines faster and to reduce the investment to build manufacturing facilities, in addition to allowing for the possible streamlining of regulatory processes. The new technologies also make possible the rapid development of human monoclonal antibodies that could become a potent immediate response to an emergency. So far, several proposals to approach EIDs have been made independently by scientists, the private sector, national governments, and international organizations such as the World Health Organization (WHO). While each of them has merit, there is a need for a global governance that is capable of taking a strong leadership role and making it attractive to all partners to come to the same table and to coordinate the global approach.
authors.affiliation: Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115.
authors.forename: David E
authors.initials: DE
authors.lastname: Bloom
authors.affiliation: Center for Global Health, Cincinnati Children's Hospital, Cincinnati, OH 45229.
authors.forename: Steven
authors.initials: S
authors.lastname: Black
authors.affiliation: GlaxoSmithKline Vaccines, 53100 Siena, Italy rino.r.rappuoli@gsk.com.
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
mesh_terms: D057231:Climate Change; D021821:Communicable Diseases, Emerging / Q000276:immunology / Q000517:prevention & control*; D014943:Global Health; D006801:Humans; D014612:Vaccines / Q000627:therapeutic use*; D014944:World Health Organization
chemical_list: D014612:Vaccines
keywords: Ebola; Zika; emerging infectious diseases; human monoclonals; vaccines