title: Immunomodulatory Magnetic Microspheres for Augmenting Tumor-Specific Infiltration of Natural Killer (NK) Cells.
abstract: The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. IMM-MS composed of recombinant interferon gamma (IFN-γ), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared IMM-MS exhibited a sustained IFN-γ release and highly sensitive MR T2contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition of IMM-MS significantly increased NK-cell infiltration into the liver tumor site.
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
authors.forename: Wooram
authors.identifier: http://orcid.org/0000-0002-4614-0530
authors.initials: W
authors.lastname: Park
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Gordon
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
authors.forename: Soojeong
authors.initials: S
authors.lastname: Cho
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.
authors.forename: Kathleen R
authors.initials: KR
authors.lastname: Harris
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.|Robert H. Lurie Comprehensive Cancer Center , Chicago, Illinois 60611, United States.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Larson
authors.affiliation: Department of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois 60611, United States.|Robert H. Lurie Comprehensive Cancer Center , Chicago, Illinois 60611, United States.
authors.forename: Dong-Hyun
authors.identifier: http://orcid.org/0000-0001-6815-3319
authors.initials: DH
authors.lastname: Kim
mesh_terms: D000818:Animals; D007371:Interferon-gamma; D007694:Killer Cells, Natural; D008113:Liver Neoplasms; D008279:Magnetic Resonance Imaging; D008863:Microspheres; D011817:Rabbits
chemical_list: D007371:Interferon-gamma
keywords: and image-guided therapy; cancer immunotherapy; interferon-gamma (IFN-γ); microspheres; natural killer (NK) cells infiltration