title: Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis.
abstract: The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat (VNTR) polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios (ORs) with 95% confidence intervals (CIs). A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL (OR = 1.17, 95% CI = 1.02-1.33) and 2 allele vs. L allele (OR = 1.18, 95% CI = 1.00-1.40). Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and Hospital-Based subgroup (i.e., study samples obtained from hospital inpatients). In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.
authors.affiliation: Department of Gastroenterology, Second Hospital of Gansu Province, Lanzhou, China.|Department of Medicine, School of Second Clinical Medicine, Northwest University for Nationalities, Lanzhou, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology, Liangzhou Hospital, Wuwei, China.
authors.forename: Jiemin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Second Hospital of Gansu Province, Lanzhou, China.|Department of Medicine, School of Second Clinical Medicine, Northwest University for Nationalities, Lanzhou, China.
authors.forename: Fuhua
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Liangzhou Hospital, Wuwei, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pathogenic Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Jian
authors.identifier: http://orcid.org/0000-0002-4884-5905
authors.initials: J
authors.lastname: Han
mesh_terms: D016481:Helicobacter Infections / Q000235:genetics* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein