title: Abnormal wiring of CCK+basket cells disrupts spatial information coding.
abstract: The function of cortical GABAergic interneurons is largely determined by their integration into specific neural circuits, but the mechanisms controlling the wiring of these cells remain largely unknown. This is particularly true for a major population of basket cells that express the neuropeptide cholecystokinin (CCK). Here we found that the tyrosine kinase receptor ErbB4 was required for the normal integration into cortical circuits of basket cells expressing CCK and vesicular glutamate transporter 3 (VGlut3). The number of inhibitory synapses made by CCK+VGlut3+basket cells and the inhibitory drive they exerted on pyramidal cells were reduced in conditional mice lacking ErbB4. Developmental disruption of the connectivity of these cells diminished the power of theta oscillations during exploratory behavior, disrupted spatial coding by place cells, and caused selective alterations in spatial learning and memory in adult mice. These results suggest that normal integration of CCK+basket cells in cortical networks is key to support spatial coding in the hippocampus.
authors.affiliation: Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom.|Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Del Pino
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain.
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Brotons-Mas
authors.affiliation: Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom.|MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, United Kingdom.
authors.forename: André
authors.initials: A
authors.lastname: Marques-Smith
authors.affiliation: Neurocentre Magendie INSERM U1215, 33077 Bordeaux, France.
authors.forename: Aline
authors.initials: A
authors.lastname: Marighetto
authors.affiliation: Neurocentre Magendie INSERM U1215, 33077 Bordeaux, France.
authors.forename: Andreas
authors.initials: A
authors.lastname: Frick
authors.affiliation: Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom.|Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain.|MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, United Kingdom.
authors.forename: Oscar
authors.initials: O
authors.lastname: Marín
authors.affiliation: Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, United Kingdom.|Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d'Alacant 03550, Spain.|MRC Centre for Neurodevelopmental Disorders, King's College London, London SE1 1UL, United Kingdom.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rico
mesh_terms: D026922:Amino Acid Transport Systems, Acidic / Q000378:metabolism; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000378:metabolism / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology*; D002766:Cholecystokinin / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D059330:GABAergic Neurons / Q000378:metabolism / Q000502:physiology*; D007395:Interneurons / Q000378:metabolism / Q000502:physiology; D008124:Locomotion / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D000071037:Place Cells / Q000502:physiology; D065808:Prepulse Inhibition / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology; D066247:Receptor, ErbB-4 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D065853:Spatial Learning / Q000502:physiology*; D065852:Spatial Memory / Q000502:physiology*; D013826:Theta Rhythm / Q000502:physiology
chemical_list: D026922:Amino Acid Transport Systems, Acidic; D002766:Cholecystokinin; D066247:Receptor, ErbB-4; C504941:Slc17a8 protein, mouse