title: Peripheral arterial stiffness is associated with higher baseline plasma uric acid: A prospective cohort study.
abstract: This prospective cohort study aimed at identifying association between uric acid (UA) and peripheral arterial stiffness. A prospective cohort longitudinal study was performed according to an average of 4.8 years' follow-up. The demographic data, anthropometric parameters, peripheral arterial stiffness (carotid-radial pulse-wave velocity, cr-PWV) and biomarker variables including UA were examined at both baseline and follow-up. Pearson's correlations were used to identify the associations between UA and peripheral arterial stiffness. Further logistic regressions were employed to determine the associations between UA and arterial stiffness. At the end of follow-up, 1447 subjects were included in the analyses. At baseline, cr-PWV (r= 0.200,p< 0.001) was closely associated with UA. Furthermore, the follow-up cr-PWV (r= 0.145,p< 0.001) was also strongly correlated to baseline UA in Pearson's correlation analysis. Multiple regressions also indicated the association between follow-up cr-PWV (β= 0.493,p= 0.013) and baseline UA level. Logistic regressions revealed that higher baseline UA level was an independent predictor of arterial stiffness severity assessed by cr-PWV at follow-up cross-section. Peripheral arterial stiffness is closely associated with higher baseline UA level. Furthermore, a higher baseline UA level is an independent risk factor and predictor for peripheral arterial stiffness.
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China; Department of Health Care and Geriatrics, Lanzhou General Hospital of Lanzhou Military Command, Lanzhou 730050, Gansu Province, China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xiaona
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Cao
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Wenkai
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wu
keywords: BMI, body mass index; Community-based; Cr, creatinine; DBP, diastolic blood pressure; FBG, fasting blood glucose; Follow-up; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MetS, metabolic syndrome; OR, odds ratio; PWV, pulse-wave velocity; Peripheral arterial stiffness; SBP, systolic blood pressure; UA, uric acid; Uric acid, risk factor; cr-PWV, carotid-radial PWV