title: In vivo toxicity evaluation of aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb. fruit.
abstract: Terminalia bellirica (Gaertn.) Roxb. (Family: Combretaceae), known as Bhibhitaki in Sanskrit and locally known as Behera in India is one of the oldest medicinal plants which has widely been used in the traditional system of medicine, especially in Ayurveda for centuries. The dried fruit of Terminalia bellirica is used for treating various ailments. Aqueous acetone extract of Terminalia bellirica (Gaertn.) Roxb fruits (AATB), showed antioxidant potential in our screening study is selected for the present in vivo toxicity evaluation. Acute administration of AATB was done in female Wistar Albino rats as a single dose up to 2000 mg/kg body weight. At the end of the study, Blood was collected for biochemical and hematological analyses, while histological examinations were performed on liver and kidney. There was no alteration in the behavioral pattern, food and water intake in the treated animals. The relative organ weight, biochemical parameters, hematological parameters and histopathological analysis were also found normal. All the parameters of the toxicity evaluation were found to be normal and the data suggests aqueous acetone extract of Terminalia bellirica fruit is safe, to be used as a traditional herbal formulation for its antioxidant potential and other health benefits.
authors.affiliation: School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.
authors.forename: Kuriakose
authors.initials: K
authors.lastname: Jayesh
authors.affiliation: School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.
authors.forename: Lal Raisa
authors.initials: LR
authors.lastname: Helen
authors.affiliation: School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.
authors.forename: A
authors.initials: A
authors.lastname: Vysakh
authors.affiliation: School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India.
authors.forename: Eldhose
authors.initials: E
authors.lastname: Binil
authors.affiliation: School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala, India. Electronic address: mslathasbs@yahoo.com.
authors.forename: M S
authors.initials: MS
authors.lastname: Latha
mesh_terms: D000096:Acetone; D000818:Animals; D005260:Female; D005638:Fruit / Q000737:chemistry*; D007194:India; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D029766:Terminalia / Q000737:chemistry*; D018675:Toxicity Tests
chemical_list: D010936:Plant Extracts; D000096:Acetone
keywords: Acute toxicity study; Aqueous acetone extract; Lethal dose; Terminalia bellirica