title: L-Glutamine Supplementation Alleviates Constipation during Late Gestation of Mini Sows by Modifying the Microbiota Composition in Feces.
abstract: Constipation occurs frequently in both sows and humans, particularly, during late gestation. The microbial community of the porcine gut, the enteric microbiota, plays a critical role in functions that sustain intestinal health. Hence, microbial regulation during pregnancy may be important to prevent host constipation. The present study was conducted to determine whether L-glutamine (Gln) supplementation improved intestinal function and alleviated constipation by regulation of enteric microbiota. 16S rRNA sequences obtained from fecal samples from 9 constipated sows (3 in the constipation group and 6 in the 1.0% Gln group) were assessed from gestational day 70 to 84. Comparative analysis showed that the abundance of intestinal-friendly microbiota, that is, Bacteroidetes (P= 0.007) and Actinobacteria (P= 0.037), was comparatively increased in the 1.0% Gln group, while the abundance of pernicious bacteria,Oscillospira(P< 0.001) andTreponema(P= 0.011), was decreased. Dietary supplementation with 1.0% Gln may ameliorate constipation of sows by regulated endogenous gut microbiota.
authors.affiliation: Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
authors.forename: Yuanyuan
authors.identifier: 0000-0002-9171-5129
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
authors.forename: Taofeng
authors.initials: T
authors.lastname: Lu
authors.affiliation: Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
authors.forename: Lingxia
authors.initials: L
authors.lastname: Han
authors.affiliation: Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
authors.forename: Yinjie
authors.initials: Y
authors.lastname: Niu
authors.affiliation: Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
authors.forename: Hongyan
authors.identifier: 0000-0001-6398-3073
authors.initials: H
authors.lastname: Chen
mesh_terms: D039903:Actinobacteria / Q000187:drug effects; D000818:Animals; D041963:Bacteroidetes / Q000187:drug effects; D003248:Constipation / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D019587:Dietary Supplements; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D005973:Glutamine / Q000008:administration & dosage*; D006801:Humans; D011247:Pregnancy; D013552:Swine
chemical_list: D005973:Glutamine