title: Chronic Pancreatitis-Like Change in BRCA2 Mutation Carriers.
abstract: Pancreatic intraepithelial neoplasia lesions can appear as chronic pancreatitis-like changes on endoscopic ultrasound (EUS). The aim of our study was to determine if BRCA2 mutation carriers were more likely than noncarriers to demonstrate chronic pancreatitis-like changes on EUS.
  
  
  
  Patients with BRCA2 mutations referred for EUS were identified (cases) from an endoscopy database. Controls were matched with cases in a 2:1 ratio for sex, date EUS was performed, endoscopist, and echoendoscope. Data were extracted from medical records, EUS reports, and EUS images. Rosemont classification was used to categorize chronic pancreatitis-like changes.
  
  
  
  During the study period, 37 BRCA2 mutation carriers and 92 controls underwent EUS. Compared with controls, BRCA2 mutation carriers had a higher prevalence of solid pancreas lesions (16.2% vs 1.08%; P = 0.005), pancreatic cysts (21.6% vs 6.1%; P = 0.01), Rosemont "consistent with chronic pancreatitis" definition changes (13.5% vs 1%; P = 0.002), and Rosemont "suggestive of chronic pancreatitis" definition changes (16.2% vs 2.1%; P = 0.003). After adjusting for age, alcohol use, and smoking, BRCA2 mutation carriers were almost 25 times more likely to demonstrate chronic pancreatitis-like changes.
  
  
  
  Chronic pancreatitis-like changes, along with solid and cystic pancreatic lesions, were significantly more common in BRCA2 mutation carriers than in noncarriers.
authors.affiliation: From the Divisions of *Gastroenterology, †Surgical Oncology, and ‡Medical Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
authors.forename: Meir
authors.initials: M
authors.lastname: Mizrahi
authors.forename: Jennifer F
authors.initials: JF
authors.lastname: Tseng
authors.forename: Daniel
authors.initials: D
authors.lastname: Wong
authors.forename: Nadine
authors.initials: N
authors.lastname: Tung
authors.forename: Mariam F
authors.initials: MF
authors.lastname: Eskander
authors.forename: Tyler M
authors.initials: TM
authors.lastname: Berzin
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Pleskow
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Sawhney
mesh_terms: D000328:Adult; D000368:Aged; D024682:BRCA2 Protein / Q000235:genetics*; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D019160:Endosonography; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010179:Pancreas / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D050500:Pancreatitis, Chronic / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human