title: Sex Differences in Severe Aortic Stenosis　- Clinical Presentation and Mortality.
abstract: There is a paucity of data on the sex differences in the prevalence, clinical presentation, and prognosis of aortic stenosis (AS).
  
  
  
  A total of 3,815 consecutive patients with severe AS were enrolled in the multicenter CURRENT AS registry between January 2003 and December 2011. The registry included 1,443 men (38%) and 2,372 women (62%). Women were much older than men (79±10 vs. 75±10 years, P<0.0001), and the ratio of women to men increased with age. The cumulative 5-year incidence of all-cause death was significantly higher in men than in women (47% vs. 41%, P=0.003), although women were more symptomatic and much older. The 5-year mortality was similar between men and women at age <65 years (16% vs. 15%, P=0.99), whereas it was significantly higher in men than in women at age ≥65 years (65-74 years, 38% vs. 19%, P<0.0001; 75-84 years, 55% vs. 34%, P<0.0001; ≥85 years: 82% vs. 72%, P=0.03).
  
  
  
  A large Japanese multicenter registry of consecutive patients with severe AS included a much higher proportion of women than men, with the female:male sex ratio increasing with age. The 5-year mortality rate of women was lower than that of men. Lower 5-year mortality rates in women were consistently seen across all age groups >65 years.
authors.affiliation: Department of Cardiology, Japanese Red Cross Wakayama Medical Center.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Toyofuku
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Taniguchi
authors.affiliation: Department of Clinical Epidemiology, Hyogo College of Medicine.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morimoto
authors.affiliation: Department of Cardiology, Kokura Memorial Hospital.
authors.forename: Kyohei
authors.initials: K
authors.lastname: Yamaji
authors.affiliation: Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Furukawa
authors.affiliation: Department of Cardiology, Japanese Red Cross Wakayama Medical Center.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Cardiology, Japanese Red Cross Wakayama Medical Center.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tamura
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shiomi
authors.affiliation: Department of Cardiology, Kokura Memorial Hospital.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ando
authors.affiliation: Division of Cardiology, Shimada Municipal Hospital.
authors.forename: Norio
authors.initials: N
authors.lastname: Kanamori
authors.affiliation: Department of Cardiology, Shizuoka City Shizuoka Hospital.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Murata
authors.affiliation: Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitai
authors.affiliation: Department of Cardiovascular Medicine, Kurashiki Central Hospital.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kawase
authors.affiliation: Department of Cardiology, Tenri Hospital.
authors.forename: Chisato
authors.initials: C
authors.lastname: Izumi
authors.affiliation: Department of Cardiology, Tenri Hospital.
authors.forename: Makoto
authors.initials: M
authors.lastname: Miyake
authors.affiliation: Division of Cardiology, Nara Hospital, Kinki University Faculty of Medicine.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Mitsuoka
authors.affiliation: Department of Cardiology, Mitsubishi Kyoto Hospital.
authors.forename: Masashi
authors.initials: M
authors.lastname: Kato
authors.affiliation: Department of Cardiology, Kindai University Hospital.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hirano
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Matsuda
authors.affiliation: Department of Cardiovascular Center, Osaka Red Cross Hospital.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Inada
authors.affiliation: Department of Cardiology, Koto Memorial Hospital.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Murakami
authors.affiliation: Department of Cardiology, Shizuoka General Hospital.
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Takeuchi
authors.affiliation: Department of Cardiology, Nishikobe Medical Center.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Yamane
authors.affiliation: Department of Cardiology, National Hospital Organization Kyoto Medical Center.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ishii
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
authors.forename: Eri
authors.initials: E
authors.lastname: Minamino-Muta
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
authors.forename: Takao
authors.initials: T
authors.lastname: Kato
authors.affiliation: Cardiovascular Center, Tazuke Kofukai Medical Research Institute, Kitano Hospital.
authors.forename: Moriaki
authors.initials: M
authors.lastname: Inoko
authors.affiliation: Department of Cardiology, Hikone Municipal Hospital.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: Department of Cardiology, Kansai Electric Power Hospital.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Komasa
authors.affiliation: Department of Cardiology, Kansai Electric Power Hospital.
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Ishii
authors.affiliation: Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center.
authors.forename: Kozo
authors.initials: K
authors.lastname: Hotta
authors.affiliation: Department of Cardiology, Japanese Red Cross Otsu Hospital.
authors.forename: Nobuya
authors.initials: N
authors.lastname: Higashitani
authors.affiliation: Department of Cardiology, Saiseikai Noe Hospital.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kato
authors.affiliation: Department of Cardiology, Shiga Medical Center for Adults.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Inuzuka
authors.affiliation: Department of Cardiology, Hamamatsu Rosai Hospital.
authors.forename: Chiyo
authors.initials: C
authors.lastname: Maeda
authors.affiliation: Department of Cardiology, Japanese Red Cross Otsu Hospital.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Jinnai
authors.affiliation: Department of Cardiology, Hirakata Kohsai Hospital.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Morikami
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
authors.forename: Naritatsu
authors.initials: N
authors.lastname: Saito
authors.affiliation: Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine.
authors.forename: Kenji
authors.initials: K
authors.lastname: Minatoya
authors.affiliation: Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012042:Registries; D012720:Severity of Illness Index; D012727:Sex Characteristics; D012737:Sex Factors
keywords: Aortic stenosis; Aortic valve replacement; Mortality; Sex difference