title: RESIDUAL INTRARETINAL EDEMA AFTER 25-GAUGE VITRECTOMY AND MACULAR PUCKER REMOVAL: Is Intraoperative Sustained-release Dexamethasone a Real Treatment Option?
abstract: OBJECTIVE
  To investigate the efficacy and safety of intraoperative slow-release dexamethasone implant and 25-gauge (G) vitrectomy plus epiretinal membrane removal in patients affected by idiopathic macular pucker.
  
  
  METHODS
  In this randomized, clinical, multicenter study, 60 eyes of 60 pseudophakic eyes having idiopathic macular pucker were enrolled. Thirty eyes underwent 25-G pars plana vitrectomy and internal limiting membrane peeling ("Control group"), whereas 30 eyes underwent 25-G pars plana vitrectomy and internal limiting membrane peeling combined with dexamethasone implant ("DEX group"). Best-corrected visual acuity was investigated using Snellen visual acuity ratio. Anatomical outcomes (foveal thickness and total macular volume) were analyzed with spectral domain optical coherence tomography.
  
  
  RESULTS
  After 6-month follow-up, best-corrected visual acuity significantly increased in each group (P < 0.05), but there were no significant differences between groups (P = 0.60). Foveal thickness showed a significant decrease in both groups (P < 0.05), but no differences were seen between groups (P = 0.80). Finally, also total macular volume decreased significantly in both groups at the last follow-up visit (P < 0.05), but both groups a showed similar trend (P = 0.12).
  
  
  CONCLUSIONS
  Intraoperative sustained-release dexamethasone implant, a powerful antiinflammatory agent with significant efficacy in vitrectomized eyes, did not result in a significant change in macular thickness and volume compared with the vitrectomy alone without dexamethasone implant at 6-month follow-up. These data support the hypothesis that its etiology does not seem to be mainly related to an inflammatory process.
authors.affiliation: Department of Surgical, Medical and Molecular Pathology and of Critical, University of Pisa, Pisa, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Guidi
authors.affiliation: Department of Surgical, Medical and Molecular Pathology and of Critical, University of Pisa, Pisa, Italy.
authors.forename: Giamberto
authors.initials: G
authors.lastname: Casini
authors.affiliation: Unit of Surgical Retina, "G. B. Bietti" Foundation, IRCCS, Rome, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Ripandelli
authors.affiliation: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.|National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona.
authors.forename: Paolo
authors.initials: P
authors.lastname: Piaggi
authors.affiliation: Department of Surgical, Medical and Molecular Pathology and of Critical, University of Pisa, Pisa, Italy.
authors.forename: Flavio
authors.initials: F
authors.lastname: Dalle Lucche
authors.affiliation: Department of Surgical, Medical and Molecular Pathology and of Critical, University of Pisa, Pisa, Italy.
authors.forename: Mariasole
authors.initials: M
authors.lastname: Sartini
authors.affiliation: Department of Surgical, Medical and Molecular Pathology and of Critical, University of Pisa, Pisa, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Loiudice
authors.affiliation: Department of Surgical, Medical and Molecular Pathology and of Critical, University of Pisa, Pisa, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Nasini
authors.affiliation: Unit of Surgical Retina, "G. B. Bietti" Foundation, IRCCS, Rome, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Stirpe
authors.affiliation: Unit of Surgical Retina, "G. B. Bietti" Foundation, IRCCS, Rome, Italy.|Operative Unit of Ophthalmology, Azienda Ospedaliera Carlo Poma di Mantova, Mantova, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Lazzeri
mesh_terms: D000368:Aged; D001485:Basement Membrane / Q000601:surgery; D003692:Delayed-Action Preparations; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008266:Macula Lutea / Q000473:pathology / Q000601:surgery; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000601:surgery*; D012189:Retrospective Studies; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations; D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone