title: Acquired Fanconi syndrome in two dogs following long-term consumption of pet jerky treats in Japan: case report.
abstract: Renal Fanconi syndrome has recently been associated with the ingestion of pet jerky treats from China in mostly small breed dogs in North America, Australia and Europe. We report here about two dogs with Fanconi syndrome following pet jerky treats exposure in Japan. A mixed-breed dog and a French bulldog showed weight loss, polyuria and polydipsia. For years, the owners had been feeding large quantities of pet jerky treats containing chicken prepared in China. Diagnostics revealed glycosuria without hyperglycemia, severe aminoaciduria, and in one case also ketonuria, hypokalemia and metabolic acidosis. A diagnosis of Fanconi syndrome associated with long-term consumption of Chinese pet jerky treats was made. Both dogs recovered fully following withdrawal of the pet jerky treats and supportive care. Fanconi syndrome of dogs in association with the consumption of pet jerky treats of Chinese origin can cause a broad proximal tubular defect with glycosuria and generalized amino aciduria, and should be also considered in Asia. Jerky treats associated Fanconi syndrome can be completely reversible following withdrawal of the treats and supportive care to correct the metabolic abnormalities.
authors.affiliation: Laboratory of Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yabuki
authors.affiliation: Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Iwanaga
authors.affiliation: Section of Medical Genetics, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104-6010, U.S.A.
authors.forename: Urs
authors.initials: U
authors.lastname: Giger
authors.affiliation: Laboratory of Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Sawa
authors.affiliation: Laboratory of Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan.
authors.forename: Moeko
authors.initials: M
authors.lastname: Kohyama
authors.affiliation: Laboratory of Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Kohrimoto, Kagoshima 890-0065, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
mesh_terms: D000821:Animal Feed / Q000009:adverse effects*; D000818:Animals; D002645:Chickens; D002681:China; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D005198:Fanconi Syndrome / Q000209:etiology* / Q000662:veterinary*; D005260:Female; D007564:Japan; D008297:Male
keywords: Fanconi syndrome; glycosuria/glucosuria; jerky treats; kidney; renal tubular defect