title: Multiple clear-cell sarcomas of small intestine with parotid gland metastasis: A case report.
abstract: Clear-cell sarcoma is a rare, malignant soft tissue tumor that displays melanocytic differentiation with a distinct molecular profile. It is rarely localized in the gastrointestinal tract. Herein we reported a case of multiple synchronous clear-cell sarcomas of the gastrointestinal tract with parotid gland metastasis. A 51-year-old male patient presented with a growing painless mass under the right ear. A preoperative positron emission tomography/computed tomography showed multiple intestinal masses and a mass in the right parotid with increased glucose uptake, and he underwent operative treatment with resection of three tumors in the jejunum and ileum and then received a right parotidectomy. Postoperative pathological examination showed that cells in the intestinal tumor were consistent with clear-cell sarcoma of the gastrointestinal tract, and the malignant cells in the parotid gland were similar to the intestinal tumor. Immunohistochemical studies revealed positive expression of HMB-45, Melan-A, and S-100. EWSR1 gene fusion transcripts were undetectable by fluorescencein situhybridization.
authors.affiliation: Hao Su, Peng Wang, Lei Shi, Hai-Tao Zhou, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Su
authors.affiliation: Hao Su, Peng Wang, Lei Shi, Hai-Tao Zhou, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Liu
authors.affiliation: Hao Su, Peng Wang, Lei Shi, Hai-Tao Zhou, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Ren
authors.affiliation: Hao Su, Peng Wang, Lei Shi, Hai-Tao Zhou, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Hao Su, Peng Wang, Lei Shi, Hai-Tao Zhou, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: Hao Su, Peng Wang, Lei Shi, Hai-Tao Zhou, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Zhou
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology; D058965:MART-1 Antigen / Q000378:metabolism; D008297:Male; D058950:Melanoma-Specific Antigens / Q000378:metabolism; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010306:Parotid Gland / Q000473:pathology*; D000072078:Positron Emission Tomography Computed Tomography; D009418:S100 Proteins / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D018227:Sarcoma, Clear Cell / Q000175:diagnosis* / Q000473:pathology*; D058951:gp100 Melanoma Antigen
chemical_list: D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D009418:S100 Proteins; D058951:gp100 Melanoma Antigen
keywords: Clear-cell sarcomas; Clear-cell sarcomas of the gastrointestinal tract; Immunohistochemistry; Parotid gland metastasis