title: Intravitreal Dexamethasone Implant for Treatment of Serous Macular Detachment in Central Retinal Vein Occlusion.
abstract: To evaluate the effect of intravitreal dexamethasone implant (Ozurdex) treatment on serous macular detachment (SMD) in patients with nonischemic central retinal vein occlusion (CRVO).
  
  
  
  Retrospective, interventional, noncomparative case series was conducted. Twenty-four eyes of 24 patients with macular edema (ME) and SMD secondary to nonischemic CRVO made up the study population. Patients who had received intravitreal triamcinolone and/or antivascular endothelial growth factor treatment and/or had undergone retinal photocoagulation were excluded from the study. After Ozurdex injection, visual and anatomical responses were observed.
  
  
  
  The mean follow-up time was 9.96 ± 2.44 months (minimum 7, maximum 14). After injection of Ozurdex, ME and SMD regressed except for 1 patient. Twenty cases showed relapse within a 5.45 ± 1.43 months mean time. Seventeen of them had SMD. Eight cases revealed a second relapse and 1 case revealed a third relapse after retreatments. The mean time for the second relapse was 5.50 ± 1.19 months. The height of SMD was found to be lower in all follow-up examinations-including relapses-than baseline measurements. The median SMD value decreased from 247.5 μm (minimum 80, maximum 745) at baseline to 0 μm (minimum 0, maximum 426) at the final examination (P < 0.001). No eyes lost vision at any control visit. The mean best corrected visual acuity increased from 0.89 ± 0.31 logMAR at baseline to 0.62 ± 0.31 logMAR at the final examination (P < 0.01). No local or systemic complication was observed.
  
  
  
  In this case series, Ozurdex was found as a safe and effective treatment for SMD and ME associated with nonischemic CRVO.
authors.affiliation: Department of Ophthalmology, Bezmialem Vakif University School of Medicine , Istanbul, Turkey .
authors.forename: Ahmet
authors.initials: A
authors.lastname: Elbay
authors.affiliation: Department of Ophthalmology, Bezmialem Vakif University School of Medicine , Istanbul, Turkey .
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozdemir
authors.affiliation: Department of Ophthalmology, Bezmialem Vakif University School of Medicine , Istanbul, Turkey .
authors.forename: Arif
authors.initials: A
authors.lastname: Koytak
authors.affiliation: Department of Ophthalmology, Bezmialem Vakif University School of Medicine , Istanbul, Turkey .
authors.forename: Arif
authors.initials: A
authors.lastname: Melikov
mesh_terms: D000368:Aged; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004343:Drug Implants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy*; D008297:Male; D011247:Pregnancy; D012170:Retinal Vein Occlusion / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D004343:Drug Implants; D003907:Dexamethasone
keywords: VEGF; anti-inflammatory; efficacy; interleukins; retina