title: Ischemic Conditioning in Kidney Transplantation.
abstract: Ischemia-reperfusion injury is a composite of the injury sustained during a period of reduced or absent blood flow to a tissue or organ and the additional insult sustained on reperfusion, which limits the amount of tissue that can be salvaged. Ischemia-reperfusion injury is the predominant insult during kidney transplantation, contributing to graft dysfunction, increased rates of acute rejection, and reduced rejection-free graft survival. In this review, we discuss the potential therapeutic benefits of a cost-effective and low-risk intervention, ischemic preconditioning, and its potential for improving kidney function following transplantation.
authors.affiliation: 1 Wessex Kidney Centre, Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom.|2 Research & Development, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
authors.forename: Kristin
authors.initials: K
authors.lastname: Veighey
authors.affiliation: 3 Clinical Pharmacology, Centre for Clinical Pharmacology, University College London, London, United Kingdom.
authors.forename: Raymond
authors.initials: R
authors.lastname: MacAllister
mesh_terms: D000818:Animals; D018572:Disease-Free Survival; D006084:Graft Rejection / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D019194:Ischemic Preconditioning / Q000379:methods*; D016030:Kidney Transplantation / Q000009:adverse effects*; D055031:Primary Graft Dysfunction / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D012039:Regional Blood Flow; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: heart disease; ischemia–reperfusion injury; renal