title: Molecular characterization of lysyl oxidase-mediated extracellular matrix remodeling during mouse decidualization.
abstract: The establishment of decidualization is a prerequisite of successful pregnancy. Lysyl oxidase (Lox) is a copper-containing amine oxidase which catalyzes cross-linking of collagen and elastin in the ECM. Lox is expressed in the subluminal stroma surrounding the implanting blastocyst on day 5 of pregnancy. From days 6 to 8, the signals for Lox mRNA and protein are strongly detected in the decidual cells. The expression of Lox is under the control of estrogen via the GSK-3β/β-catenin/c-myc pathway. Dtprp is decreased by the inhibition of Lox activity. Furthermore, the inhibition of Lox activity decreases stromal cell migration and embryo adhesion. Our findings highlight the crucial role of Lox in endometrial stromal cells and deepen our understanding of decidualization.
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Shu-Yun
authors.initials: SY
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Jia-Qi
authors.initials: JQ
authors.lastname: Yan
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Song
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Yue-Fang
authors.initials: YF
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Min-Jie
authors.initials: MJ
authors.lastname: Song
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Jia-Wen
authors.initials: JW
authors.lastname: Qin
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Zeng-Ming
authors.initials: ZM
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
authors.forename: Xiao-Huan
authors.initials: XH
authors.lastname: Liang
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000378:metabolism*; D002465:Cell Movement; D003656:Decidua / Q000502:physiology*; D010064:Embryo Implantation; D004967:Estrogens / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D011247:Pregnancy; D011388:Prolactin / Q000031:analogs & derivatives* / Q000378:metabolism; D008249:Protein-Lysine 6-Oxidase / Q000235:genetics* / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D017154:Stromal Cells / Q000166:cytology; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism
chemical_list: C489796:Dtprp protein, mouse; D004967:Estrogens; D016326:Extracellular Matrix Proteins; C489428:Myc protein, mouse; D016271:Proto-Oncogene Proteins c-myc; D051176:beta Catenin; C077112:Lox protein, mouse; D011388:Prolactin; D008249:Protein-Lysine 6-Oxidase
keywords: Lox; decidualization; uterus