title: Exposing HIV's weaknesses.
abstract: The viral restriction factor SERINC5 inhibits HIV-1 infection via unknown mechanisms. Sood and co-workers now show that SERINC5 suppresses HIV-1 fusogenicity and increases sensitivity to neutralizing antibodies by perturbing the folding of the fusion machinery. This work advances our understanding of host-virus interactions and provides a compelling case for considering the host immune system in studies of restriction factor mechanisms.
authors.affiliation: From the Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, tedburyp@missouri.edu.|Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, and.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Tedbury
authors.affiliation: From the Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, sarafianoss@missouri.edu.|Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri, and.|the Department of Biochemistry, University of Missouri, Columbia, Missouri 65212.
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Sarafianos
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008565:Membrane Proteins / Q000276:immunology*; D017510:Protein Folding; D053586:Virus Internalization
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D008565:Membrane Proteins; C000602387:SERINC5 protein, human