title: Impact of dexmedetomidine on hemodynamic changes during and after coronary artery bypass grafting.
abstract: OBJECTIVE
  To determine the effect of dexmedetomidine (Dex) on hemodynamic changes during cardiopulmonary pump and postoperative period in coronary artery bypass grafting (CABG).
  
  
  METHODS
  This study is designed as a double-blinded, randomized clinical trial.
  
  
  METHODS
  University hospital and single center.
  
  
  METHODS
  patients candidate for elective CABG.
  
  
  METHODS
  Dex 0.5 μg/kg/h or placebo was infused from the initiation of anesthesia up to extubation in Intensive Care Unit (ICU).
  
  
  METHODS
  Heart rate (HR) and blood pressure (BP), pain score, and total morphine dose requirement were monitored and compared during cardiac pump up to 12 h postoperative in ICU.
  
  
  RESULTS
  Mean arterial pressure was significantly higher in Dex group in postoperation period at 1 (P = 0.010) and 2 h (P = 0.002) compared to control group. HR was significantly lower in Dex group in postcardiopulmonary bypass (CPB) time at 0 h (P = 0.001), 1 h (P = 0.0016), and 2 h (P = 0.001), and then in postoperative period in ICU at 1 h (P = 0.025), 2 h (P = 0.0012), and 4 h (P = 0.0025) compared to control group. Postoperative pain score was significantly lower during 12 h after surgery.
  
  
  CONCLUSIONS
  Dex could effectively blunt hemodynamic response to surgical stress, particularly during CPB pump and afterward. Infusion of Dex maintains BP at higher range and HR at lower range compared to placebo.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Hashemian
authors.affiliation: Department of Anesthesiology and Pain Medicine, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ahmadinejad
authors.affiliation: Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Amir
authors.initials: SA
authors.lastname: Mohajerani
authors.affiliation: Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mirkheshti
mesh_terms: D001026:Coronary Artery Bypass; D020927:Dexmedetomidine / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine