title: Efficacy of steroid therapy based on symptomatic and functional improvement in patients with vestibular neuritis: a prospective randomized controlled trial.
abstract: The aim of this study was to examine the efficacy of methylprednisolone in vestibular neuritis (VN) by objective and subjective measures. This prospective controlled randomized study was conducted at one tertiary hospital. Twenty-nine VN patients were randomized to either the steroid (n = 15) or the control (n = 14) group. The steroid group received methylprednisolone for 2 weeks, whereas control patients did not; both groups underwent regular vestibular exercises and were prescribed a Ginkgo biloba. Vestibular function tests including caloric test, video head impulse test (vHIT), and sensory organization test (SOT) were performed, and dizziness handicap index (DHI) was determined at enrollment; all tests were repeated at 1 and 6 months after enrollment. Both groups showed statistically significant improvements in caloric weakness and vHIT gain at 1- and 6-month follow-up evaluations compared to the initial examination; however, differences were not significant. The rates of normalization of canal paresis at 1 and 6 months were 50 and 64% in the control group and 33 and 60% in the steroid group, respectively, with no differences between the two groups. The rates of vHIT normalization at 1 and 6 months after treatment were 57 and 78% in the control group and 53 and 87% in the steroid group, respectively, with no differences between the two groups. Finally, there were no significant differences in the improvement of composite scores of SOT and the DHI scores between the two groups. In this prospective RCT, methylprednisolone had no additional benefit in patients with VN who underwent vestibular exercises and received a Ginkgo biloba.
  
  
  BACKGROUND
  Clinicaltrials.gov Identifier, NCT02098330; Trial title, The Efficacy of Steroid Therapy in Vestibular Neuritis.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Kyungpook National University, Daegu, South Korea.
authors.forename: Myung Hoon
authors.initials: MH
authors.lastname: Yoo
authors.affiliation: Department of Otolaryngology, Hanil General Hospital, Seoul, South Korea.
authors.forename: Chan Joo
authors.initials: CJ
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Shin Ae
authors.initials: SA
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Marn Joon
authors.initials: MJ
authors.lastname: Park
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Joong Ho
authors.initials: JH
authors.lastname: Ahn
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea.
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Chung
authors.affiliation: Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, 88 Olympicro-43-gil, Songpa-gu, Seoul, 138-736, South Korea. dzness@amc.seoul.kr.
authors.forename: Hong Ju
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D002150:Caloric Tests / Q000379:methods; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D064087:Head Impulse Test / Q000379:methods; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014717:Vertigo / Q000175:diagnosis / Q000209:etiology; D020338:Vestibular Neuronitis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D014722:Vestibule, Labyrinth / Q000503:physiopathology
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone
keywords: Caloric test; Head impulse test; Methylprednisolone; Steroid; Vertigo; Vestibular neuritis