title: Clinicopathology of EpCAM and EGFR in Human Epithelial Ovarian Carcinoma.
abstract: The objective of this study was to explore the expression of EpCAM and EGFR in human epithelial ovarian cancer (EOC) and their correlation with clinicopathological parameters. The protein expression levels of epithelial cell adhesion molecule (EpCAM) and epidermal growth factor receptor (EGFR) were evaluated by immunohistochemistry in formalin-fixed paraffin-embedded specimens from 30 patients with epithelial ovarian carcinoma and 15 normal ovary tissues. Clinicopathological characteristics were gathered by retrospective review of the patients' files. The correlation between EpCAM and EGFR expression, as well as their association with clinical pathological parameters were investigated. The SPSS 17.0 package was used to perform statistical analyses. The positive expression rates of EpCAM and EGFR were significantly elevated in epithelial ovarian cancer tissues than in normal ovary tissues. The positive expressions of EpCAM and EGFR in EOC were associated with International Federation of Gynecology and Obstetrics (FIGO) stage and tumor differentiation, lymph node metastasis. Spearman correlation analysis demonstrated a significant positive association between EpCAM and EGFR expression in EOC. The co-expression of EpCAM and EGFR may play an important role in the carcinogenesis of EOC and might provide a promising molecular therapeutic target.
authors.affiliation: epartment of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
authors.forename: Jingying
authors.initials: J
authors.lastname: Zheng
authors.affiliation: School of Nursing, Jilin University, Changchun, Jilin 130021, China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, People's Hospital of Jilin Province, Changchun, Jilin 130021, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, Jilin 130041, China.
authors.forename: Shuhua
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, Jilin 130041, China.
authors.forename: Manhua
authors.initials: M
authors.lastname: Cui
keywords: EGFR; EpCAM; Epithelial ovarian cancer; Immunohistochemistry