title: [Association of inflammatory genes with neuroticism, anxiety and depression in male patients with coronary heart disease].
abstract: OBJECTIVE
  To explore the relationship of depression and its endophenotypes (neuroticism and trait anxiety) with inflammatory genes in patients with coronary heart disease (CHD).
  
  
  METHODS
  A sample consisted of 78 male CHD patients with depression, 91 CHD patients without depression and 127 healthy men. Polymorphisms of the genes encoding interleukine-4 (IL-4 -589 C/T), interleukine-6 (IL-6 -174 G/C), tumor-necrosis factor alpha (TNF-α -308 G/A) and C-reactive protein (CRP -717A/G) were studied.
  
  
  RESULTS
  There was the association between the IL-6 -174 G/C and depression comorbid to CHD (р=0.01; OR=2.3 CI 95% 1.2-4.3). The frequency of the 'high expression' allele G in this group was higher compared to controls. The association between IL-4 -589 C/T and CHD was found. Compared to the control group, the frequency of the IL-4 -589CC genotype was higher in patients regardless of whether they had symptoms of depression (р=0.007; OR=2.1 CI 95% 1.2-3.4). No association between the TNF-α -308G/A and the CRP -717A/G with depression in CHD was observed. There were no differences between neuroticism and anxiety scores in patients with different IL-4 -589 C/T, IL-6 -174 G/C, TNF-α -308 G/A, CRP -717A/G genotypes.
  
  
  CONCLUSIONS
  The finding of the association between the IL-6 -174G/C and depression, comorbid to CHD, is in line with literature on a role of IL-6 in the development of depression in patients with CHD.
authors.affiliation: Mental Health Research, Moscow, Russia.
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.affiliation: Sechenov First Moscow Medical University, Moscow, Russia.
authors.forename: B A
authors.initials: BA
authors.lastname: Volel
authors.affiliation: Mental Health Research, Moscow, Russia.
authors.forename: G I
authors.initials: GI
authors.lastname: Korovaitseva
authors.affiliation: Mental Health Research, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Kasparov
authors.affiliation: Mental Health Research, Moscow, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Kondratiev
authors.affiliation: Sechenov First Moscow Medical University, Moscow, Russia.
authors.forename: F Yu
authors.initials: FY
authors.lastname: Kopylov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001007:Anxiety / Q000235:genetics*; D001008:Anxiety Disorders / Q000235:genetics*; D002097:C-Reactive Protein / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics*; D003863:Depression / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D000075384:Neuroticism; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: C508598:IL4 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D002097:C-Reactive Protein