title: Management and investigation of neonatal encephalopathy: 2017 update.
abstract: This review discusses an approach to determining the cause of neonatal encephalopathy, as well as current evidence on resuscitation and subsequent management of hypoxic-ischaemic encephalopathy (HIE). Encephalopathy in neonates can be due to varied aetiologies in addition to hypoxic-ischaemia. A combination of careful history, examination and the judicious use of investigations can help determine the cause. Over the last 7 years, infants with moderate to severe HIE have benefited from the introduction of routine therapeutic hypothermia; the number needed to treat for an additional beneficial outcome is 7 (95% CI 5 to 10). More recent research has focused on optimal resuscitation practices for babies with cardiorespiratory depression, such as delayed cord clamping after establishment of ventilation and resuscitation in air. Around a quarter of infants with asystole at 10 min after birth who are subsequently cooled have normal outcomes, suggesting that individualised decision making on stopping resuscitation is needed, based on access to intensive treatment unit and early cooling. The full benefit of cooling appears to have been exploited in our current treatment protocols of 72 hours at 33.5°C; deeper and longer cooling showed adverse outcome. The challenge over the next 5-10 years will be to assess which adjunct therapies are safe and optimise hypothermic brain protection in phase I and phase II trials. Optimal care may require tailoring treatments according to gender, genetic risk, injury severity and inflammatory status.
authors.affiliation: Department of Neonatology, Institute for Women's Health, University College London, UK.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Martinello
authors.affiliation: Department of Neonatal and Paediatric Neurology, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Hart
authors.affiliation: Department of Inherited Metabolic Diseases, Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK.
authors.forename: Sufin
authors.initials: S
authors.lastname: Yap
authors.affiliation: Department of Neonatology, Institute for Women's Health, University College London, UK.
authors.forename: Subhabrata
authors.initials: S
authors.lastname: Mitra
authors.affiliation: Department of Neonatology, Institute for Women's Health, University College London, UK.
authors.forename: Nicola J
authors.identifier: http://orcid.org/0000-0002-5783-0828
authors.initials: NJ
authors.lastname: Robertson
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications*; D002658:Developmental Disabilities / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D016896:Treatment Outcome
keywords: hypoxic ischaemic encephalopathy; neonatal encephalopathy; neuroprotection; resuscitation of the newborn