title: GABA spectra and remote distractor effect in progressive supranuclear palsy: A pilot study.
abstract: Disturbances of the gamma-aminobutyric-acid (GABA) system have been suspected of contributing to the pathophysiology of progressive supranuclear palsy (PSP). The ability to rapidly resolve competitive action decisions, such as shifting the gaze to one particular stimulus rather than another, can be predicted by the concentration of GABA in the region of the frontal cortex relevant to eye movements. For this reason, our study measured GABA levels in seven PSP patients and eight healthy controls, using proton magnetic resonance spectroscopy, and assessed the relationship of these measurements to the remote distractor effect (RDE), an eye-movement paradigm investigating competitive action decisions. No significant differences were found in either frontal-eye-field GABA levels or RDE between PSP patients and controls.
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic; Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, 75013 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bonnet
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Rusz
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic; Department of Neurosurgery, Hospital Na Homolce, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Hanuška
authors.affiliation: MR-unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Dezortová
authors.affiliation: MR-unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: F
authors.initials: F
authors.lastname: Jírů
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic; Department of Cybernetics, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Sieger
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Jech
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Klempíř
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Roth
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic.
authors.forename: O
authors.initials: O
authors.lastname: Bezdíček
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Serranová
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Dušek
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic.
authors.forename: T
authors.initials: T
authors.lastname: Uher
authors.affiliation: AP-HP, Hospital de Bicêtre, Department of Neurology, 94270 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Flammand-Roze
authors.affiliation: MR-unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Hájek
authors.affiliation: Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic. Electronic address: eruzi@lf1.cuni.cz.
authors.forename: E
authors.initials: E
authors.lastname: Růžička
mesh_terms: D000368:Aged; D005133:Eye Movements; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000000981:diagnostic imaging / Q000503:physiopathology; D010775:Photic Stimulation; D010865:Pilot Projects; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D012438:Saccades; D013494:Supranuclear Palsy, Progressive / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D014794:Visual Fields; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid
keywords: Distraction; Eye movements; GABA; Magnetic resonance; Progressive supranuclear palsy; Spectroscopy