title: Autologous platelet-rich plasma versus readymade growth factors in skin rejuvenation: A split face study.
abstract: BACKGROUND
  The escalating urge for a youthful-looking skin instigates continuous innovations with minimally invasive procedures. Readymade growth factors and autologous platelet-rich plasma (PRP) represent such therapeutic interventions.
  
  
  OBJECTIVE
  Compare the efficacy and safety of PRP to readymade growth factors in skin rejuvenation.
  
  
  METHODS
  Twenty adult females with Fitzpatrick skin types III-IV and Glogau photoaging types II and III were enrolled in this study. They underwent a split face therapy where each side was randomly assigned to treatment by either readymade growth factors (area A) or autologous PRP (area B). All patients received six sessions at 2-weeks interval. Evaluation was carried out using Global Aesthetic Improvement Scale (GAIS) and optical coherence tomography (OCT). Patients were followed up for 6 months.
  
  
  RESULTS
  Both procedures yielded significant improvement regarding both GAIS (skin turgor and overall vitality) and OCT (epidermal and dermal thickness) assessment. Significant negative correlation was detected between patients' age, sun exposure, and GAIS. Burning sensation was significantly higher in area A. Patient satisfaction was significantly higher in area B. Improvement was more sustained in area B on follow-up.
  
  
  CONCLUSIONS
  Platelet-rich plasma is effective and safe for skin rejuvenation, comparable to readymade growth factors with noticeable higher longevity.
authors.affiliation: Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Heba I
authors.identifier: http://orcid.org/0000-0003-0318-1655
authors.initials: HI
authors.lastname: Gawdat
authors.affiliation: Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Amira M
authors.initials: AM
authors.lastname: Tawdy
authors.affiliation: Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Rehab A
authors.initials: RA
authors.lastname: Hegazy
authors.affiliation: Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Mohga M
authors.initials: MM
authors.lastname: Zakaria
authors.affiliation: Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Ryham S
authors.initials: RS
authors.lastname: Allam
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008875:Middle Aged; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D012060:Rejuvenation; D012867:Skin
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: 
  OCT
  ; 
  PRP
  ; efficacy; readymade growth factors; skin rejuvenation