title: Functional evidence that progenitor cells near sites of inflammation are precursors for aggressive prostate cancer.
abstract: While chronic inflammation has been causally associated with several epithelial malignancies, whether it causally contributes to the development of prostate cancer has remained unclear. We recently reported that progenitor-like inflammation-associated luminal cells marked by low expression of Cluster of Differentiation 38 (CD38) can initiate human prostate cancer and predict poor outcome.
authors.affiliation: Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Preston D
authors.initials: PD
authors.lastname: Crowell
authors.affiliation: Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA; Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Goldstein
keywords: CD38; Luminal; Prostate cancer; stem cell