title: Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a Toy Poodle.
abstract: A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact ulna. After fixation by a locking plate and screws, adipose-derived mesenchymal stem-cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture was healed at 9 weeks after surgery. In the present case, the mesenchymal stem-cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea.
authors.forename: Jaeyong
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Yongsun
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
authors.forename: Oh-Kyeong
authors.initials: OK
authors.lastname: Kweon
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea.
authors.forename: Byung-Jae
authors.initials: BJ
authors.lastname: Kang
mesh_terms: D000818:Animals; D055419:Bone Morphogenetic Protein 7 / Q000627:therapeutic use*; D004285:Dogs / Q000293:injuries* / Q000601:surgery; D005599:Fractures, Ununited / Q000601:surgery / Q000628:therapy / Q000662:veterinary*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary*
chemical_list: D055419:Bone Morphogenetic Protein 7
keywords: adipose-derived mesenchymal stromal cells; bone morphogenetic protein 7; dogs; ununited fractures