title: Vascular impairment as a pathological mechanism underlying long-lasting cognitive dysfunction after pediatric traumatic brain injury.
abstract: Traumatic brain injury (TBI) is the leading cause of death and disability in children. Indeed, the acute mechanical injury often evolves to a chronic brain disorder with long-term cognitive, emotional and social dysfunction even in the case of mild TBI. Contrary to the commonly held idea that children show better recovery from injuries than adults, pediatric TBI patients actually have worse outcome than adults for the same injury severity. Acute trauma to the young brain likely interferes with the fine-tuned developmental processes and may give rise to long-lasting consequences on brain's function. This review will focus on cerebrovascular dysfunction as an important early event that may lead to long-term phenotypic changes in the brain after pediatric TBI. These, in turn may be associated with accelerated brain aging and cognitive dysfunction. Finally, since no effective treatments are currently available, understanding the unique pathophysiological mechanisms of pediatric TBI is crucial for the development of new therapeutic options.
authors.affiliation: CNRS UMR 5287, INCIA, University of Bordeaux, France.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Ichkova
authors.affiliation: CNRS UMR 5287, INCIA, University of Bordeaux, France.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Rodriguez-Grande
authors.affiliation: CNRS UMR 5287, INCIA, University of Bordeaux, France; Department of Pediatric Neurology, University Children's Hospital of Bordeaux, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Bar
authors.affiliation: Department of Pediatric Neurology, University Children's Hospital of Bordeaux, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Villega
authors.affiliation: CNRS UMR 5287, INCIA, University of Bordeaux, France.
authors.forename: Jan Pieter
authors.initials: JP
authors.lastname: Konsman
authors.affiliation: CNRS UMR 5287, INCIA, University of Bordeaux, France; Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address: jerome.badaut@u-bordeaux.fr.
authors.forename: Jerome
authors.initials: J
authors.lastname: Badaut
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D000070642:Brain Injuries, Traumatic / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D060825:Cognitive Dysfunction / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D010372:Pediatrics; D013997:Time Factors; D057772:Vascular System Injuries / Q000473:pathology* / Q000503:physiopathology
keywords: Cerebrovascular dysfunction; Development; Neurovascular unit; Pediatric; Traumatic brain injury