title: Effect of liver cirrhosis on long-term outcomes after acute respiratory failure: A population-based study.
abstract: OBJECTIVE
  To assessed the effect of liver cirrhosis (LC) on the poorly understood long-term mortality risk after first-ever mechanical ventilation (1-MV) for acute respiratory failure.
  
  
  METHODS
  All patients in Taiwan given a 1-MV between 1997 and 2013 were identified in Taiwan's Longitudinal Health Insurance Database 2000. Each patient with LC was individually matched, using a propensity-score method, to two patients without LC. The primary outcome was death after a 1-MV.
  
  
  RESULTS
  A total of 16653 patients were enrolled: 5551 LC-positive (LC[Pos]) patients, including 1732 with cryptogenic LCs and 11102 LC-negative (LC[Neg]) controls. LC[Pos]patients had more organ failures and were more likely to be admitted to medical department than were LC[Neg]controls. LC[Pos]patients had a significantly lower survival rate (AHR = 1.38, 95%CI: 1.32-1.44). Moreover, the mortality risk was significantly higher for patients with non-cryptogenic LC than for patients with cryptogenic LC (AHR = 1.43, 95%CI: 1.32-1.54) and patients without LC (AHR = 1.56, 95%CI: 1.32-1.54). However, there was no significant difference between patients with cryptogenic and without LC (HR = 1.05, 95%CI: 0.98-1.12).
  
  
  CONCLUSIONS
  LC, especially non-cryptogenic LC, significantly increases the risk of death after a 1-MV.
authors.affiliation: Chih-Cheng Lai, Chien-Ming Chao, Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan.
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Lai
authors.affiliation: Chih-Cheng Lai, Chien-Ming Chao, Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan.
authors.forename: Chung-Han
authors.initials: CH
authors.lastname: Ho
authors.affiliation: Chih-Cheng Lai, Chien-Ming Chao, Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan.
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Cheng
authors.affiliation: Chih-Cheng Lai, Chien-Ming Chao, Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan.
authors.forename: Chien-Ming
authors.initials: CM
authors.lastname: Chao
authors.affiliation: Chih-Cheng Lai, Chien-Ming Chao, Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan.
authors.forename: Chin-Ming
authors.initials: CM
authors.lastname: Chen
authors.affiliation: Chih-Cheng Lai, Chien-Ming Chao, Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan.
authors.forename: Willy
authors.initials: W
authors.lastname: Chou
mesh_terms: D000368:Aged; D000465:Algorithms; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012121:Respiration, Artificial / Q000009:adverse effects*; D012128:Respiratory Distress Syndrome / Q000150:complications*; D012189:Retrospective Studies; D013624:Taiwan; D016896:Treatment Outcome
keywords: Liver cirrhosis; Mechanical ventilation; Outcome