title: Readily Accessible 1,2-Amino Ether Ligands for Enantioselective Intramolecular Carbolithiation.
abstract: A new class of chiral 1,2-amino ether ligands, readily accessible from naturally occurring α-amino- or α-hydroxy acids, was found to provide high levels of both conversion and stereocontrol (up to 95:5 er) in intramolecular carbolithiation reactions, outperforming the benchmark ligand (-)-sparteine. The ligand could be used in a substoichiometric amount (0.25 equiv) without significant loss of enantioselectivity.
authors.affiliation: Université du Maine and CNRS UMR 6283, Institut des Molécules et Matériaux du Mans , Faculté des Sciences et Techniques, avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Guyon
authors.affiliation: Université du Maine and CNRS UMR 6283, Institut des Molécules et Matériaux du Mans , Faculté des Sciences et Techniques, avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Boussonnière
authors.affiliation: Université du Maine and CNRS UMR 6283, Institut des Molécules et Matériaux du Mans , Faculté des Sciences et Techniques, avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France.
authors.forename: Anne-Sophie
authors.identifier: 0000-0003-4704-4724
authors.initials: AS
authors.lastname: Castanet