title: Light up detection of heparin based on aggregation-induced emission and synergistic counter ion displacement.
abstract: Heparin is a widely used anticoagulant and the quantification of heparin concentration is pivotal for clinical use. However, previous fluorescent probes for heparin detection are usually based on fluorophores with aggregation-caused quenching (ACQ) properties, which severely restrict their applications for quantitative measurement of heparin in a wide range. Herein, we develop an aggregation-induced emission (AIE) probe HPQ-TBP-I for light up detection of heparin based on the electrostatic interaction-triggered formation of the HPQ-TBP/heparin complex and simultaneous displacement of the fluorescence quencher iodide ion. A linear relationship from 0 to 14 μM of heparin accompanied with a low detection limit of 22 nM was achieved, which fully covers the whole clinical dose range (1.7-10 μM). It is anticipated that this easily accessible and sensitive AIE probe is promising for clinical applications.
authors.affiliation: State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China. msqinaj@scut.edu.cn.
authors.forename: Shiwu
authors.initials: S
authors.lastname: Li
authors.forename: Meng
authors.initials: M
authors.lastname: Gao
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.forename: Rongrong
authors.initials: R
authors.lastname: Hu
authors.forename: Zujin
authors.initials: Z
authors.lastname: Zhao
authors.forename: Anjun
authors.initials: A
authors.lastname: Qin
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang