title: Structural and Functional State of Erythrocyte Membranes in Mice at Different Stages of Experimental Parkinson's Disease Induced by Administration of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP).
abstract: We studied some structural and functional parameters of erythrocyte membranes in mice at the late presymptomatic and early symptomatic stages of experimental Parkinson's disease induced by administration of MPTP (hemolysis, microviscosity of different regions of the lipid bilayer, LPO intensity, activity of antioxidant enzymes, and kinetic properties of acetylcholinesterase). At the presymptomatic stage, significant deviations of the studied parameters from the normal were observed; they were similar in direction and magnitude to those in humans with Parkinson's disease. At the early symptomatic stage, most parameters tended to normal. Microviscosity of bulk lipids increased at the presymptomatic stage and decreased after appearance of clinical symptoms. This dynamics probably reflects activation of compensatory mechanisms aimed at inhibition of oxidative stress triggered by the development of the pathological process.
authors.affiliation: N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia. bcp_lfat@mail.ru.
authors.forename: L D
authors.initials: LD
authors.lastname: Fatkullina
authors.affiliation: N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: E M
authors.initials: EM
authors.lastname: Molochkina
authors.affiliation: N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Kozachenko
authors.affiliation: N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: L G
authors.initials: LG
authors.lastname: Nagler
authors.affiliation: N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: E B
authors.initials: EB
authors.lastname: Burlakova
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D004910:Erythrocyte Membrane / Q000378:metabolism* / Q000473:pathology; D007700:Kinetics; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress; D020734:Parkinsonian Disorders / Q000097:blood* / Q000139:chemically induced; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D008315:Malondialdehyde; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D013482:Superoxide Dismutase; D000110:Acetylcholinesterase
keywords: acetylcholinesterase; erythrocytes; experimental Parkinson’s disease; oxidative stress; structure of membrane