title: Synthesis of Enantiomerically Pure (8S,9S,10R,6Z)-Trihydroxyoctadec-6-enoic Acid.
abstract: We have accomplished the asymmetric synthesis of (8S,9S,10R,6Z)-trihydroxyoctadec-6-enoic acid in optically pure form and determined the absolute configuration of the natural product on the basis of the stereodetermined chiral building block 7, which was prepared by the catalytic enantioselective allylic oxidation of 4,5-epoxycyclohex-1-ene using an S-configured N,N-bidentate ligand-copper catalyst.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kobe University , Nada, Kobe 657-8501, Japan.
authors.forename: Jogula
authors.initials: J
authors.lastname: Srinivas
authors.affiliation: Department of Chemistry, Graduate School of Science, Kobe University , Nada, Kobe 657-8501, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Namito
authors.affiliation: Department of Chemistry, Graduate School of Science, Kobe University , Nada, Kobe 657-8501, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Matsubara
authors.affiliation: Department of Chemistry, Graduate School of Science, Kobe University , Nada, Kobe 657-8501, Japan.
authors.forename: Masahiko
authors.identifier: 0000-0002-1716-6686
authors.initials: M
authors.lastname: Hayashi