title: [Drug interaction of voriconazole-cyclosporine in children undergoing hematopoietic stem cell transplantation (2013-2014)].
abstract: BACKGROUND
  Drug interactions (DI) in patients receiving hematopoietic stem cell transplantation (HSCT) are common and clinically significant, highlighting: anticonvulsants, voriconazole (VCZ) and cyclosporine (CsA), which require monitoring.
  
  
  OBJECTIVE
  To describe the interactions between CsA-VCZ in children undergoing HSCT.
  
  
  METHODS
  Retrospective, descriptive study in immunocompromised children hospitalized since January 2013 to December 2014 at Bone Marrow Transplant Unit, Hospital Dr. Luis Calvo Mackenna, who received CsA and VCZ.
  
  
  RESULTS
  The median age was 5 years (3-6) and the median weight was 20 kg (17-30). Sixtythree baseline drug levels were analyzed, of those, 27 were CsA drug levels obtained previous to using VCZ and 36 were CsA drug levels collected concomitantly with VCZ. In the group CsA previous to VCZ, the CsA dose was 4.6 ± 2.6 (mg/ kg/ day) and the CsA average level was 188.8 ± 84.1 (μg/ml). In the group of CsA concomitantly with VCZ, the dose of CsA was 5.5 ± 3.0 (mg/ kg/day) (p = 0.07) and CsA average level was significantly higher: 232.5 ± 106.7 (μg/ml) (p = 0.04).
  
  
  CONCLUSIONS
  This study shows an increased level of CsA when it is used together with VCZ. Therapeutic drug monitoring could improve the management of the DI and optimize the co-administration of CsA and VCZ.
authors.affiliation: Departamento de Pediatría Unidad de Investigación, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Romina
authors.initials: R
authors.lastname: Valenzuela
authors.affiliation: Departamento de Pediatría Unidad de Investigación, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Torres
authors.affiliation: Departamento de Pediatría Unidad de Investigación, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Carolina
authors.initials: C
authors.lastname: Salas
authors.affiliation: Departamento de Pediatría Unidad de Investigación, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: Iván
authors.initials: I
authors.lastname: Gajardo
authors.affiliation: Unidad de Trasplante de Medula Ósea, Hospital Dr. Luis Calvo Mackenna, Chile.
authors.forename: Julia
authors.initials: J
authors.lastname: Palma
authors.affiliation: Unidad de Trasplante de Medula Ósea, Hospital Dr. Luis Calvo Mackenna, Chile.
authors.forename: Paula
authors.initials: P
authors.lastname: Catalán
authors.affiliation: Departamento de Pediatría Unidad de Investigación, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
authors.forename: M Elena
authors.initials: ME
authors.lastname: Santolaya
authors.affiliation: Unidad de Farmacia, Hospital Dr. Luis Calvo Mackenna, Chile.
authors.forename: Jorge
authors.initials: J
authors.lastname: Morales
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage* / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage* / Q000097:blood; D004347:Drug Interactions; D016903:Drug Monitoring; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors; D065819:Voriconazole / Q000008:administration & dosage* / Q000097:blood
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D065819:Voriconazole