title: Molecular Design and Medicinal Applications of Nano-Nitric Oxide Delivery Systems.
abstract: BACKGROUND
  Nitric oxide (NO) plays important regulatory roles in a plethora of biological functions and thus holds tremendous potential to be exploited for clinical uses. However, the chemistries in the molecular design of nano-nitric oxide delivery systems is currently lacking.
  
  
  OBJECTIVE
  The overarching aim of this review is to provide the readers with the fundamentals that relate to the design of NO release molecules (NORMs), loading and releasing mechanism, as well as delivery of NORMs for nanotherapeutics.
  
  
  METHODS
  We conducted a thorough literature search on the design and synthesis of NORMs, as well as the current state-of-the-art NO compatible delivery platforms to address various clinical needs.
  
  
  RESULTS
  N-diazeniumdiolate and S-nitrosothiol based NO molecules are among the most widely used NORMs for anti-cancer and anti-microbial applications. The innovative integration of these NORMs with cytocompatible organic and inorganic nanocarriers enabled controlled spatiotemporal delivery and release of NO at the targeted diseased sites.
  
  
  CONCLUSIONS
  We have provided a comprehensive summary of the fundamental chemistries underpinning the molecular design of the NORMs and critically assessed the recent advancements of nano-NO delivery systems for advanced biomedical applications.
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
authors.forename: Kim Truc
authors.initials: KT
authors.lastname: Nguyen
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
authors.forename: Zhuoran
authors.initials: Z
authors.lastname: Wu
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
authors.forename: Tiantian
authors.initials: T
authors.lastname: Huang
authors.affiliation: School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.|School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
authors.forename: Chor Yong
authors.initials: CY
authors.lastname: Tay
mesh_terms: D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D065546:Drug Liberation / Q000528:radiation effects; D006801:Humans; D008027:Light; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D020030:Nitric Oxide Donors / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004337:Drug Carriers; D020030:Nitric Oxide Donors
keywords: Nitric oxide; biomedical applications; controlled delivery; molecular design; nano-biomaterials; therapeutic
  gas.