title: Proximal-Type Epithelioid Sarcoma: Report of an Unusual Case in the Uterine Cervix.
abstract: Epithelioid sarcoma is a rare malignant mesenchymal neoplasm (less than 1% of all sarcomas) with epithelioid morphology. Among the 2 subtypes, proximal represents only one-third of cases and commonly involves deep tissues of pelvic region, including the perineum, genital area, and groin, and occurs more frequently in older patients who present a more aggressive course. In the female genital tract, proximal-type epithelioid sarcoma (PES) mainly affects the vulva and is extremely uncommon in the uterus. To our knowledge, only a few cases of PES involving the cervix and uterine body have been previously reported in the literature. We report a 23-year-old woman who presented with abnormal vaginal bleeding. She was found to have a cervical mass, which was resected and diagnosed as a hemangioendothelioma. However, 2 months later, the mass recurred and the histopathological analysis at our institution demonstrated a PES confined to the uterine cervix. It is important to include this neoplasm in the differential diagnosis of epithelioid tumors that can involve the female genital tract because it has a significant impact on prognosis and treatment.
authors.affiliation: 1 Hospital Universitario Fundación Santa Fe de Bogotá, Bogota DC, Colombia.
authors.forename: David Alfonso
authors.initials: DA
authors.lastname: Suárez-Zamora
authors.affiliation: 1 Hospital Universitario Fundación Santa Fe de Bogotá, Bogota DC, Colombia.
authors.forename: Luis Eduardo
authors.initials: LE
authors.lastname: Barrera-Herrera
authors.affiliation: 1 Hospital Universitario Fundación Santa Fe de Bogotá, Bogota DC, Colombia.|2 Universidad de los Andes, Bogota DC, Colombia.
authors.forename: Paula Andrea
authors.initials: PA
authors.lastname: Rodríguez-Urrego
authors.affiliation: 1 Hospital Universitario Fundación Santa Fe de Bogotá, Bogota DC, Colombia.|2 Universidad de los Andes, Bogota DC, Colombia.
authors.forename: Mauricio Alfonso
authors.initials: MA
authors.lastname: Palau-Lázaro
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D035583:Rare Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012509:Sarcoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D014592:Uterine Hemorrhage / Q000209:etiology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: mesenchymal neoplasm; proximal-type epithelioid sarcoma; uterine cervix