title: An Unusual Diterpene-Enhygromic Acid and Deoxyenhygrolides from a Marine Myxobacterium, Enhygromyxa sp.
abstract: Three new compounds, enhygromic acid (1) and deoxyenhygrolides A (2) and B (3), were isolated from a marine myxobacterium,Enhygromyxasp. Compound1was found to be an acrylic acid derivative with a rare polycyclic carbon skeleton, decahydroacenaphthylene, by spectroscopic analyses. Compounds2and3were deoxy analogs of the known γ-alkylidenebutenolides, enhygrolides. Compound1exhibited cytotoxicity against B16 melanoma cells and anti-bacterial activity againstBacillus subtilis, and enhanced the NGF-induced neurite outgrowth of PC12 cells.
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan. ttomura@agr.nagoya-u.ac.jp.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Tomura
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan. nagashima.shiori@d.mbox.nagoya-u.ac.jp.
authors.forename: Shiori
authors.initials: S
authors.lastname: Nagashima
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan. yamazaki.satoshi@a.mbox.nagoya-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamazaki
authors.affiliation: Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Kanagawa 210-8681, Japan. takashi_iizuka@ajinomoto.com.
authors.forename: Takashi
authors.initials: T
authors.lastname: Iizuka
authors.affiliation: R & D Planning Department, Ajinomoto Co., Inc., Chuo-ku, Tokyo 104-8315, Japan. ryosuke_fudou@ajinomoto.com.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Fudou
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan. ojika@agr.nagoya-u.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ojika
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D009231:Myxococcales / Q000737:chemistry*; D016501:Neurites / Q000737:chemistry; D016716:PC12 Cells; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes
keywords: NGF-enhancing activity; antibacterial activity; cytotoxicity; diterpene; marine myxobacterium