title: Prognostic significance of latent membrane protein 1 expression in non-Hodgkin lymphoma: A meta-analysis.
abstract: BACKGROUND
  The prognostic value of latent membrane protein 1 (LMP1) in non-Hodgkin lymphoma (NHL) has been evaluated in several studies. However, the conclusions remain controversial.
  
  
  METHODS
  We searched relevant literatures from Embase, PubMed, and China National Knowledge Infrastructure Platform databases and performed a meta-analysis to evaluate the prognostic significance of LMP1 expression in NHL. Pooled hazard ratio (HR), 95% confidence interval (CI), and P value were calculated. Nine relevant studies were analyzed in this meta-analysis. We performed a pooled analysis to assess the association between LMP1 expression and overall survival of NHL patients.
  
  
  RESULTS
  Our results revealed that LMP1-positive NHL patients had significantly poorer outcomes than LMP1-negative patients (HR = 2.13, 95% CI = 1.31-3.46, Pheterogeneity = 0.005, I = 63.5%). Furthermore, in the subgroup analysis stratified by country, a statistically significant association was found among Chinese (HR = 2.80, 95% CI = 1.53-5.15, Pheterogeneity = 0.342, I = 6.9%); however, no statistically significant relations were found among Japanese (HR = 1.55, 95% CI = 0.74-3.24, Pheterogeneity = 0.020, I = 65.7%).
  
  
  CONCLUSIONS
  The expression of LMP1 can be considered a poor predictor of survival in patients with NHL. In addition, LMP1 expression assessment could provide more detailed information for patients with NHL and could be used to optimize therapeutic schemes.
authors.affiliation: Department of Medical Oncology, Chinese PLA General Hospital Department of Medical Oncology, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Xiao
authors.forename: Hui-Xia
authors.initials: HX
authors.lastname: Zhao
mesh_terms: D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000378:metabolism* / Q000821:virology; D011379:Prognosis; D014763:Viral Matrix Proteins / Q000378:metabolism*
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins