title: Synthetic approaches to radiochemical probes for imaging of bacterial infections.
abstract: This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes for tomographic imaging. These molecular probes encompass leukocytes, antibodies, small molecules, peptides, antibiotics, macrolides, vitamins, oligomers and siderophores. Although this technique has shown to be a valuable tool for non-invasive infection imaging, more development is required to create easy-to-radiolabel kit solutions/procedures for the preparation of the probes.
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.
authors.forename: Jyotibon
authors.initials: J
authors.lastname: Dutta
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.
authors.forename: Tricia
authors.initials: T
authors.lastname: Naicker
authors.affiliation: University of Pretoria & Steve Biko Academic Hospital, Crn Malherbe and Steve Biko Rd, Pretoria, 0001, South Africa.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebenhan
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.
authors.forename: Hendrik G
authors.initials: HG
authors.lastname: Kruger
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa; Science for Life Laboratory, Drug Discovery and Development Platform and Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute SE-171 77 Stockholm, Sweden.
authors.forename: Per I
authors.initials: PI
authors.lastname: Arvidsson
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa. Electronic address: govenderthav@icloud.com.
authors.forename: Thavendran
authors.initials: T
authors.lastname: Govender
mesh_terms: D000818:Animals; D001419:Bacteria / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000000981:diagnostic imaging*; D006801:Humans; D015335:Molecular Probes / Q000032:analysis / Q000138:chemical synthesis; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000138:chemical synthesis; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D015335:Molecular Probes; D019275:Radiopharmaceuticals