title: Head and neck sweat gland adenocarcinoma: A population-based perspective of a rare entity.
abstract: Head and neck sweat gland adenocarcinoma (HNSGA) is an extremely rare malignancy. We present the first population-based analysis regarding this entity.
  
  
  
  Retrospective population-based analysis.
  
  
  
  Using the Surveillance, Epidemiology, and End Results registry from 2000 to 2013, we extracted 627 cases of HNSGA. Data were analyzed for incidence trends, demographic and clinicopathologic traits, and predictors of disease-specific survival (DSS).
  
  
  
  The majority HNSGA cases were white, male, and 60 to 79 years old. The incidence was 0.036 per 100,000 people. Tumors most often presented as localized disease and histological grade II/III. The skin of the face was the most common primary site (43.4%), followed by the scalp and neck (31.6%). Overall 5-, 10-, and 20-year DSS were 94.6%, 89.6%, and 79.8%, respectively. Ethnicity did not affect survival, whereas a younger age at diagnosis and female sex conferred an advantage at 10 years (P = 0.0386) and 5 years (P = 0.0191), respectively. The origin of the HNSGA (apocrine vs. eccrine) did not affect outcomes. Regional and distant disease predicted worse DSS at 5, 10, and 20 years (P = 0.0026, P < 0.001, P < 0.001, respectively). Compared to grade I/II disease, grade III/IV dramatically worsened 5-, 10-, and 20-year DSS (P = 0.0035, P < 0.0001, P = 0.0011, respectively). Scalp and neck HNSGA exhibited the poorest 20-year DSS compared to other primary sites (P = 0.0024).
  
  
  
  We present the largest cohort of HNSGA. Significant poor prognostic indicators include older age, higher tumor grade, greater extent of invasion, and primary site of the scalp or neck.
  
  
  
  4. Laryngoscope, 127:2757-2762, 2017.
authors.affiliation: Department of Otolaryngology and Facial Plastic Surgery, Rowan University School of Osteopathic Medicine, Stratford.
authors.forename: Aykut A
authors.initials: AA
authors.lastname: Unsal
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Varesh R
authors.initials: VR
authors.lastname: Patel
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Sei Y
authors.initials: SY
authors.lastname: Chung
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.
authors.forename: Albert H
authors.initials: AH
authors.lastname: Zhou
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.|Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey.
authors.forename: Soly
authors.initials: S
authors.lastname: Baredes
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery.|Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey.|Department of Neurological Surgery.|Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.
authors.forename: Jean Anderson
authors.identifier: 0000-0003-2893-7818
authors.initials: JA
authors.lastname: Eloy
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013544:Sweat Gland Neoplasms / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D055815:Young Adult
keywords: SEER; Surveillance, Epidemiology, and End Results; Sweat gland adenocarcinoma; apocrine adenocarcinoma; eccrine adenocarcinoma; head and neck cancer; head and neck sweat gland adenocarcinoma; incidence; population-based; survival