title: Helicobacter pylori Strains and Gastric MALT Lymphoma.
abstract: This article summarizes the main findings concerningHelicobacter pyloriassociated with gastric MALT lymphoma (GML). Considered together, GML strains based on their virulence factor profile appear to be less virulent than those associated with peptic ulcers or gastric adenocarcinoma. A particular Lewis antigen profile has been identified in GML strains and could represent an alternative adaptive mechanism to escape the host immune response thereby allowing continuous antigenic stimulation of infiltrating lymphocytes.
authors.affiliation: INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France. pauline.floch@u-bordeaux.fr.
authors.forename: Pauline
authors.initials: P
authors.lastname: Floch
authors.affiliation: INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France. francis.megraud@chu-bordeaux.fr.
authors.forename: Francis
authors.initials: F
authors.lastname: Mégraud
authors.affiliation: INSERM, Univ. Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France. philippe.lehours@u-bordeaux.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lehours
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology*; D013274:Stomach Neoplasms / Q000209:etiology*; D037521:Virulence Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D008070:Lipopolysaccharides; C074689:VacA protein, Helicobacter pylori; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori
keywords: Helicobacter pylori; MALT lymphoma; cag pathogenicity island; pathogenesis; virulence marker