title: Malnutrition and Quality of Life in Patients with Non-Small-Cell Lung Cancer.
abstract: Progressive weight loss, common reduces performance and quality of life in patients with advanced lung cancer. However, there is a paucity of studies that focus on nutritional status and quality of life of non-small cell lung cancer (NSCLC) patients. The present study seeks to determine the nutritional status, and its relation to quality of life, of NSCLC patients. One hundred and eighty NSCLC patients (mean age 62.8 ± 9.6 years) were evaluated during therapy at the Lower Silesian Center of Lung Diseases in Wroclaw, Poland. Nutritional status was evaluated by means of the Mini-Nutritional Assessment (MNA) and quality of life by means of two instruments developed by the European Organization for the Research and Treatment of Cancer (EORTC): QLQ-C30 and QLQ-LC13 questionnaires. The MNA revealed that up to 51.1% of patients were undernourished, 23.9% were at risk of malnutrition, and only 25.0% showed a normal nutrition. The well-nourished respondents evaluated their quality of life better in all functional scales (33.3 vs. 41.7 vs. 66.7, respectively) and presented less intensive symptoms in general QLQ-C30 and specific LC13 questionnaires. In univariate analysis, malnutrition significantly correlated with decreased quality of life and the intensity of symptoms in both questionnaires. In multivariate analysis, malnutrition was an independent determinant of decreased quality of life in physical functioning domain (β = -0.015; p < 0.001). We conclude that malnutrition has an impact on quality of life and on the presentation of symptoms in NSCLC patients. Therefore, nutritional care should be integrated into the global oncology as an adjunct to symptomatic treatment.
authors.affiliation: Lower Silesian Oncology Center, Home Hospice, 12 Hirszfeld Square, Wroclaw, 53-413, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Polański
authors.affiliation: Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Streetd, Wroclaw, 51-618, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Jankowska-Polańska
authors.affiliation: Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Streetd, Wroclaw, 51-618, Poland.
authors.forename: Izabella
authors.initials: I
authors.lastname: Uchmanowicz
authors.affiliation: Division of Surgical Procedures, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, Wroclaw, 51-618, Poland. mariusz.chabowski@gmail.com.|Department of Surgery, Fourth Military Teaching Hospital, 5 Weigla Street, Wroclaw, 50-981, Poland. mariusz.chabowski@gmail.com.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Chabowski
authors.affiliation: Division of Surgical Procedures, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, Wroclaw, 51-618, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Janczak
authors.affiliation: Department of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 213 Borowska Street, Wroclaw, 50-556, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
authors.affiliation: Department of Nervous System Diseases, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, Wroclaw, 51-618, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Rosińczuk
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D044342:Malnutrition / Q000150:complications*; D008875:Middle Aged; D011044:Poland; D011788:Quality of Life; D011795:Surveys and Questionnaires
keywords: Malnutrition, Mini-nutritional assessment; Non-small cell lung cancer; Nutrition; Quality of life