title: Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes.
abstract: This study measured the antiplasmodial activity of nine zinc-dipicolylamine (ZnDPA) complexes against three strains of Plasmodium falciparum, the causative parasite of malaria. Growth inhibition assays showed significant activity against all tested strains, with 50% inhibitory concentrations between 5 and 600nM and almost no toxic effect against host cells including healthy red blood cells. Fluorescence microscopy studies with a green-fluorescent ZnDPA probe showed selective targeting of infected red blood cells. The results suggest that ZnDPA coordination complexes are promising antiplasmodial agents with potential for targeted malaria treatment.
authors.affiliation: Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Rice
authors.affiliation: Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: María
authors.initials: M
authors.lastname: de Lourdes Betancourt Mendiola
authors.affiliation: Department of Tropical Medicine, J Bennett Johnston Building, 1430 Tulane Avenue, Tulane University, New Orleans, LA 70112, USA.
authors.forename: Claribel
authors.initials: C
authors.lastname: Murillo-Solano
authors.affiliation: Department of Biological Science, Galvin Life Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Checkley
authors.affiliation: Department of Biological Science, Galvin Life Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: Ferdig
authors.affiliation: Department of Tropical Medicine, J Bennett Johnston Building, 1430 Tulane Avenue, Tulane University, New Orleans, LA 70112, USA.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Pizarro
authors.affiliation: Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA. Electronic address: smith.115@nd.edu.
authors.forename: Bradley D
authors.initials: BD
authors.lastname: Smith
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D016466:CHO Cells; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D006224:Cricetinae; D003412:Cricetulus; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008288:Malaria / Q000188:drug therapy; D008856:Microscopy, Fluorescence; D009942:Organometallic Compounds / Q000737:chemistry*; D010847:Picolines / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D056831:Coordination Complexes; D009942:Organometallic Compounds; D010847:Picolines; C509592:zinc(II) dipicolylamine
keywords: Antiplasmodial drugs; Fluorescence microscopy; Malaria; Zinc dipicolylamine