title: Crosstalk between the Secretory and Autophagy Pathways Regulates Autophagosome Formation.
abstract: The induction of autophagy by nutrient deprivation leads to a rapid increase in the formation of autophagosomes, unique organelles that replenish the cellular pool of nutrients by sequestering cytoplasmic material for degradation. The urgent need for membranes to form autophagosomes during starvation to maintain homeostasis leads to a dramatic rearrangement of intracellular membranes. Here we discuss recent findings that have begun to uncover how different parts of the secretory pathway directly and indirectly contribute to autophagosome formation during starvation.
authors.affiliation: Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0668, USA.
authors.forename: Saralin
authors.initials: S
authors.lastname: Davis
authors.affiliation: Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0668, USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093-0668, USA. Electronic address: sfnovick@ucsd.edu.
authors.forename: Susan
authors.initials: S
authors.lastname: Ferro-Novick
mesh_terms: D000818:Animals; D000071182:Autophagosomes / Q000378:metabolism*; D001343:Autophagy; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D055571:Secretory Pathway
keywords: autophagosome formation; autophagy; secretory pathway