title: MESONEPHRIC ADENOCARCINOMA OF ENDOCERVIX WITH LOBULAR MESONEPHRIC HYPERPLASIA: CASE REPORT.
abstract: Mesonephric adenocarcinoma is a rare variant of cervical adenocarcinoma. We
  present a case of mesonephric adenocarcinoma of endocervix with cervical and vaginal lobular mesonephric
  hyperplasia in a 57-year-old woman. Vaginal bleeding persisting for 12 months was the only
  symptom. Histopathologic findings and characteristic immunophenotype are crucial for the diagnosis.
  The tumor was composed of papillary formation with a central fi brovascular stroma, villoglandular and
  densely compact tubular structures containing intraluminal eosinophilic secretion, and coated with
  one or more rows of cylindrical atypical epithelial cells. There were 30 pathologic mitotic shapes found
  per 10 HPF. The tumor invaded nearly full-thickness of cervical stroma with positive lymphovascular
  space invasion and clear margins. The case demonstrated characteristic cytokeratin 7, vimentin and
  epithelial membrane antigen positivity and high Ki-67 proliferation index (60%). Estrogen receptors,
  progesterone receptors and carcinoembryonic antigen were negative. Intratubular lumen secretion was
  periodic acid-Schiff positive with periodic acid-Schiff negative carcinoma cells. Diff erential diagnoses
  include adenoma malignum, well-diff erentiated villoglandular adenocarcinoma, endometrioid adenocarcinoma,
  serous adenocarcinoma, mesonephric adenocarcinoma with a sarcomatous component,
  clear-cell carcinoma and mesonephric hyperplasia. Radical hysterectomy with bilateral salpingo-oophorectomy,
  pelvic and para-aortic lymphadenectomy was performed. Three years after the surgery,
  the patient remains well. There has not been any evidence of local or distant recurrence. There are no
  specific recommendations for the treatment of this rare disease. It remains uncertain whether surgical
  approach is sufficient or the treatment should include additional radio/chemotherapy.
authors.forename: Mario
authors.initials: M
authors.lastname: Puljiz
authors.forename: Damir
authors.initials: D
authors.lastname: Danolić
authors.forename: Lucija
authors.initials: L
authors.lastname: Kostić
authors.forename: Ilija
authors.initials: I
authors.lastname: Alvir
authors.forename: Darko
authors.initials: D
authors.lastname: Tomica
authors.forename: Ivica
authors.initials: I
authors.lastname: Mamić
authors.forename: Ivana Vlastelica
authors.initials: IV
authors.lastname: Munivrana
authors.forename: Marko
authors.initials: M
authors.lastname: Puljiz
authors.forename: Danko Velimir
authors.initials: DV
authors.lastname: Vrdoljak
authors.forename: Melita Perić
authors.initials: MP
authors.lastname: Balja
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology*