title: Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States.
abstract: Resistance to reverse transcriptase and protease inhibitors was frequently detected in HIV from black men who have sex with men (MSM) enrolled in the HIV prevention trials network (HPTN) 061 study. In this study, integrase strand transfer inhibitor (INSTI) resistance was analyzed in black MSM enrolled in HPTN 061 (134 infected at enrollment and 23 seroconverters) and a follow-up study, HPTN 073 (eight seroconverters). The ViroSeq HIV-1 Integrase Genotyping Kit (Abbott Molecular) was used for analysis. Major INSTI resistance mutations were not detected in any of the samples. HIV from 14 (8.4%) of the 165 men, including 4 (12.9%) of 31 seroconverters, had accessory or polymorphic INSTI-associated mutations. The most frequently detected mutation was E157Q. These findings are promising because INSTI-based regimens are now recommended for first-line antiretroviral treatment and because long-acting cabotegravir is being evaluated for pre-exposure prophylaxis.
authors.affiliation: 1 Bureau of Primary Health Care, Health Resources and Services Administration , Rockville, Maryland.
authors.forename: Iris
authors.initials: I
authors.lastname: Chen
authors.affiliation: 2 Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Yinfeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 2 Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Cummings
authors.affiliation: 3 Infectious Disease Research, Abbott Diagnostics , Abbott Park, Illinois.
authors.forename: Gavin A
authors.initials: GA
authors.lastname: Cloherty
authors.affiliation: 4 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, Washington.
authors.forename: Matthew
authors.initials: M
authors.lastname: Connor
authors.affiliation: 4 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, Washington.
authors.forename: Geetha
authors.initials: G
authors.lastname: Beauchamp
authors.affiliation: 5 Science Facilitation Department, FHI 360 , Durham, North Carolina.
authors.forename: Sam
authors.initials: S
authors.lastname: Griffith
authors.affiliation: 5 Science Facilitation Department, FHI 360 , Durham, North Carolina.
authors.forename: Scott
authors.initials: S
authors.lastname: Rose
authors.affiliation: 6 Southwest Care Center , Santa Fe, New Mexico.
authors.forename: Joel
authors.initials: J
authors.lastname: Gallant
authors.affiliation: 7 Bridge HIV , San Francisco Department of Public Health, San Francisco, California.
authors.forename: Hyman M
authors.initials: HM
authors.lastname: Scott
authors.affiliation: 8 Department of Family Medicine, University of California Los Angeles , Los Angeles, California.
authors.forename: Steven
authors.initials: S
authors.lastname: Shoptaw
authors.affiliation: 9 Department of Global Health, Emory University Rollins School of Public Health , Atlanta, Georgia .
authors.forename: Carlos
authors.initials: C
authors.lastname: Del Rio
authors.affiliation: 10 Department of Epidemiology and Biostatistics, The George Washington University , Washington, District of Columbia.
authors.forename: Irene
authors.initials: I
authors.lastname: Kuo
authors.affiliation: 11 Department of Medicine, Harlem Hospital, Columbia University , Mailman School of Public Health, New York, New York.
authors.forename: Sharon
authors.initials: S
authors.lastname: Mannheimer
authors.affiliation: 12 Laboratory of Infectious Disease Prevention, Lindsley F. Kimball Research Institute , New York Blood Center, New York, New York.
authors.forename: Hong-Van
authors.initials: HV
authors.lastname: Tieu
authors.affiliation: 13 Institute for Global Health & Infectious Diseases, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Hurt
authors.affiliation: 14 School of Health Professions, New York Institute of Technology , Old Westbury, New York.
authors.forename: Sheldon D
authors.initials: SD
authors.lastname: Fields
authors.affiliation: 15 School of Social Welfare, University at Albany, State University of New York , Albany, New York.
authors.forename: Darrell P
authors.initials: DP
authors.lastname: Wheeler
authors.affiliation: 16 Fenway Health/Infectious Disease Division, The Fenway Institute , Beth Israel Deaconess Medical Center, Boston, Massachusetts.|17 Department of Medicine, Harvard Medical School , Boston, Massachusetts.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
authors.affiliation: 12 Laboratory of Infectious Disease Prevention, Lindsley F. Kimball Research Institute , New York Blood Center, New York, New York.
authors.forename: Beryl A
authors.initials: BA
authors.lastname: Koblin
authors.affiliation: 2 Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, Maryland.
authors.forename: Susan H
authors.initials: SH
authors.lastname: Eshleman
mesh_terms: D044383:Black People; D024882:Drug Resistance, Viral; D005838:Genotype; D060005:Genotyping Techniques; D015658:HIV Infections / Q000821:virology*; D019427:HIV Integrase / Q000235:genetics*; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D014481:United States; D001741:Black or African American
chemical_list: D019427:HIV Integrase
keywords: HIV integrase; drug resistance; integrase inhibitor; men who have sex with men