title: Reprogramming Interferon Regulatory Factor Signaling in Cardiometabolic Diseases.
abstract: Interferon regulatory factors (IRFs) are evolutionarily conserved proteins expressed not only in immune cells but also in other tissues and organs outside the immune system. In this review, we discuss mechanisms responsible for IRF-mediated innate immune responses and the function and mechanism of IRFs in cardiometabolic diseases. We focus on the role of IRFs in innate immunity and cardiometabolic homeostasis, and highlight reprogrammed IRF signaling.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.|Institute of Model Animal, Wuhan University, Wuhan, People's Republic of China; and.|Medical Research Institute, School of Medicine, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Yaxing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China; lihl@whu.edu.cn.|Institute of Model Animal, Wuhan University, Wuhan, People's Republic of China; and.|Medical Research Institute, School of Medicine, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Hongliang
authors.initials: H
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000276:immunology / Q000378:metabolism; D000818:Animals; D001808:Blood Vessels / Q000276:immunology / Q000378:metabolism; D001921:Brain / Q000276:immunology / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D050835:Interferon Regulatory Factors / Q000378:metabolism*; D008099:Liver / Q000276:immunology / Q000378:metabolism; D018482:Muscle, Skeletal / Q000276:immunology / Q000378:metabolism; D009206:Myocardium / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D050835:Interferon Regulatory Factors