title: Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data.
abstract: Heparanase promotes tumorigenesis, angiogenesis, and metastasis. Here, we conducted a study based on systematic review and the Cancer Genome Atlas (TCGA) data that examined heparanase expression in clinical samples to determine its prognostic value. According to the meta-analysis and TCGA data, we found that heparanase expression was up-regulated in most breast cancer specimens, and elevated heparanase expression was associated with increased lymph node metastasis, larger tumor size, higher histological grade, and poor survival. These results suggest that targeting heparanase might improve treatments for breast cancer patients.
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Sun
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Ganlin
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.|School of Graduates, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Jiayun
authors.initials: J
authors.lastname: Nian
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Neurology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.
authors.forename: Shijian
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Guowang
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Peiyu
authors.initials: P
authors.lastname: Cheng
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.|School of Graduates, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yan
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.|School of Graduates, Beijing University of Chinese Medicine, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Meng
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Oncology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.|Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005966:Glucuronidase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D063868:Patient Outcome Assessment; D011379:Prognosis; D017594:Publication Bias; D000099175:Heparanase
chemical_list: D014408:Biomarkers, Tumor; D005966:Glucuronidase; D000099175:Heparanase
keywords: breast cancer; heparanase; prognosis