title: Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor.
abstract: Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug release from the gel. Drug release and skin permeation experiments show its potential for topical administration.
authors.affiliation: Departament de Farmacologia, Toxicologia i Química Terapèutica, Universitat de Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain. mlperez@ub.edu.
authors.forename: David
authors.initials: D
authors.lastname: Limón
authors.forename: Claire
authors.initials: C
authors.lastname: Jiménez-Newman
authors.forename: Ana C
authors.initials: AC
authors.lastname: Calpena
authors.forename: Arántzazu
authors.initials: A
authors.lastname: González-Campo
authors.forename: David B
authors.initials: DB
authors.lastname: Amabilino
authors.forename: Lluïsa
authors.initials: L
authors.lastname: Pérez-García
mesh_terms: D000287:Administration, Topical; D002412:Cations / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D065546:Drug Liberation / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D007093:Imidazoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D046911:Macromolecular Substances / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010316:Particle Size; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects
chemical_list: D002412:Cations; D020100:Hydrogels; D007093:Imidazoles; D046911:Macromolecular Substances; D015842:Serine Proteinase Inhibitors