title: Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals With and Without Psoriasis.
abstract: <p>BACKGROUND: HIV-associated psoriasis is well-documented. Genetic, cellular, and cytokine profiles have been used as evidence to suggest psoriasis activates antiviral pathways. There has been a lack of epidemiologic evidence investigating whether psoriasis patients have lower HIV viral counts compared to non-psoriasis patients.</p> <p>OBJECTIVE: Compare the viral load set point of HIV positive patients with and without psoriasis.</p> <p>METHODS: A retrospective matched cohort study of HIV positive patients with and without psoriasis using the Kaiser Permanente Southern California Health Plan database.</p> <p>RESULTS: We identified 101 HIV-positive psoriasis cases; 19 met inclusion criteria and were matched with 3-5 control patients; 94 total patients were analyzed. The mean age was 41.4 (12.07) years and 83% were male. Overall, the median log of the viral load of cases was slightly higher than controls (4.3 vs 4.2; P less than 0.01).</p> <p>CONCLUSIONS: The serum viral load set point of patients with HIV and psoriasis was slightly higher than the viral load set point of HIV patients without psoriasis.</p> <p><em>J Drugs Dermatol. 2017;16(4):372-377.</em></p>.
authors.forename: Jashin J
authors.initials: JJ
authors.lastname: Wu
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Gilbert
authors.forename: Michael
authors.initials: M
authors.lastname: Batech
authors.forename: Iviensan F
authors.initials: IF
authors.lastname: Manalo
authors.forename: William J
authors.initials: WJ
authors.lastname: Towner
authors.forename: Rui André Saraiva
authors.initials: RA
authors.lastname: Raposo
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Nixon
authors.forename: Wilson
authors.initials: W
authors.lastname: Liao
mesh_terms: D000328:Adult; D000368:Aged; D002140:California; D016022:Case-Control Studies; D005260:Female; D006678:HIV / Q000302:isolation & purification*; D015658:HIV Infections / Q000097:blood* / Q000150:complications / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000150:complications; D012189:Retrospective Studies; D019562:Viral Load; D055815:Young Adult