title: Association between diverticulosis and colonic neoplastic lesions in individuals with a positive faecal immunochemical test.
abstract: BACKGROUND
  The association between diverticulosis and colonic neoplastic lesions has been suggested, but data in literature are conflicting. This study aimed to investigate such a relationship in patients participating in a colorectal cancer screening program who underwent high-quality colonoscopy.
  
  
  METHODS
  Data from consecutive individuals 50-75 years of age with a positive faecal immunological test were considered. Diverticulosis was categorised as present or absent. The prevalence of neoplastic lesions (adenoma, advanced adenoma, and cancer) between individuals with and those without diverticula was compared. A multivariate analysis was performed.
  
  
  RESULTS
  Overall, data from 970 consecutive individuals were evaluated, and diverticulosis was detected in 354 (36.5%) cases. At least one adenoma was detected in 490 (50.5%) people, at least one advanced adenoma in 264 (27.2%), multiple adenoma in 71 (7.3%), whilst a cancer was diagnosed in 48 (4.9%) cases. At univariate analysis, the adenoma detection rate in patients with diverticula was significantly higher than in controls (55.9% vs 47.4%;p= 0.011). At multivariate analysis, presence of diverticulosis was an independent risk factor for both adenoma detection rate (OR = 1.58; 95% CI = 1.14-2.18;p= 0.006) and advanced adenoma (OR = 1.57; 95% CI = 1.10-2.24;p= 0.013), but not for colorectal cancer.
  
  
  CONCLUSIONS
  In a colorectal screening setting, the adenoma detection rate was significantly higher in individuals with diverticulosis than in controls.
authors.affiliation: Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Morini
authors.affiliation: Gastroenterology Unit, 'Sapienza' University of Rome, Polo Pontino Hospital, Latina, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Ridola
authors.affiliation: Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Hassan
authors.affiliation: Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Lorenzetti
authors.affiliation: Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Boggi
authors.affiliation: Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Napoli
authors.affiliation: Oncology Unit, 'Sapienza' University of Rome, Polo Pontino Hospital, Latina, Italy.
authors.forename: Silverio
authors.initials: S
authors.lastname: Tomao
authors.affiliation: Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Zullo
keywords: Diverticulosis; adenoma; advanced adenoma; colorectal cancer