title: Efficacy of palivizumab prophylaxis on the frequency of RSV-associated lower respiratory tract infections in preterm infants: determination of the ideal target population for prophylaxis.
abstract: Respiratory syncytial virus (RSV) prophylaxis in high-risk infants is an effective intervention for the prevention of severe disease. The aim of this study was to determine the ideal target preterm population that might benefit from palivizumab prophylaxis by establishing the main risk factors for acute RSV-related infections. Former premature infants born with a gestational age ≤37 weeks and ≤1 year of age at the beginning of the RSV season and admitted with respiratory infection were included. RSV status was evaluated by RSV strip test in all infants. RSV-positive and -negative infants were compared in terms of demographic features, risk factors, requirement of hospitalisation and palivizumab administration. A total of 202 preterm infants under 1 year of age were enrolled. The RSV test was positive in 34 (16.8%) infants. Maternal age was significantly lower in RSV-positive infants compared with RSV-negative infants (p = 0.03). RSV-positive infants were found to be significantly discharged during the RSV season (p = 0.03). RSV-positive infants required significantly higher rates of hospitalisation and need for mechanical ventilation. Of the RSV-positive infants, 28 (82%) had a gestational age ≥29 weeks. Seventeen (77%) RSV-positive infants that required hospitalisation were ≥29 weeks of gestation. All infants with a gestational age ≥29 weeks and without palivizumab prophylaxis developed RSV infection. Palivizumab prophylaxis should be implemented into guidelines to cover preterm infants with a gestational age >29 weeks. Palivizumab prophylaxis should also be considered in high-risk infants ≤6 months of age during the RSV season.
authors.affiliation: Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey. drmerih@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Cetinkaya
authors.affiliation: Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: T K
authors.initials: TK
authors.lastname: Oral
authors.affiliation: Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Karatekin
authors.affiliation: Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Cebeci
authors.affiliation: Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Babayigit
authors.affiliation: Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Yesil
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D000069455:Palivizumab / Q000627:therapeutic use*; D065129:Pre-Exposure Prophylaxis; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D000069455:Palivizumab
keywords: Lower Respiratory Tract Infection; Palivizumab; Preterm Infant; Respiratory Syncytial Virus; Respiratory Syncytial Virus Infection