title: Dictating genomic destiny: Epigenetic regulation of pancreatic neuroendocrine tumours.
abstract: Pancreatic neuroendocrine tumours are a diverse group of neoplasms with an increasingly well-defined genomic basis. Despite this, much of what drives this disease is still unknown and epigenetic influences represent the next tier of gene, and hence disease modifiers that are of unquestionable importance. Moreover, they are of arguably more significance than the genes themselves given their malleable nature and potential to be exploited for not only diagnosis and prognosis, but also therapy. This review summarises what is known regarding the key epigenetic modifiers of disease through the domains of diagnosis, prognosis and treatment.
authors.affiliation: Centre for Endocrine Surgery, University College London Hospital, London, United Kingdom. Electronic address: jgundara@med.usyd.edu.au.
authors.forename: Justin S
authors.initials: JS
authors.lastname: Gundara
authors.affiliation: Centre for Endocrine Surgery, University College London Hospital, London, United Kingdom.
authors.forename: Karim
authors.initials: K
authors.lastname: Jamal
authors.affiliation: Centre for Endocrine Surgery, University College London Hospital, London, United Kingdom.
authors.forename: Tom
authors.initials: T
authors.lastname: Kurzawinski
mesh_terms: D000818:Animals; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D006801:Humans; D018358:Neuroendocrine Tumors / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics*
keywords: Epigenetic; Methylation; Neuroendocrine tumour; PNET; miRNA