title: Gene-Diet Interaction and Precision Nutrition in Obesity.
abstract: The rapid rise of obesity during the past decades has coincided with a profound shift of our living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical inactivity. Genetic predisposition to obesity may have interacted with such an obesogenic environment in determining the obesity epidemic. Growing studies have found that changes in adiposity and metabolic response to low-calorie weight loss diets might be modified by genetic variants related to obesity, metabolic status and preference to nutrients. This review summarized data from recent studies of gene-diet interactions, and discussed integration of research of metabolomics and gut microbiome, as well as potential application of the findings in precision nutrition.
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. yheianza@tulane.edu.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Heianza
authors.affiliation: Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. lqi1@tulane.edu.|Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. lqi1@tulane.edu.
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
mesh_terms: D031204:Caloric Restriction / Q000379:methods*; D005247:Feeding Behavior; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D053858:Metabolic Networks and Pathways; D054647:Nutrigenomics / Q000379:methods*; D009752:Nutritional Status; D009765:Obesity / Q000178:diet therapy* / Q000235:genetics; D057185:Sedentary Behavior
keywords: gene-diet interactions; obesity; weight loss