title: Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury.
abstract: Hepatic ischemia-reperfusion injury (HIRI) is a major cause of hepatic failure and death after liver trauma, haemorrhagic shock, resection surgery and liver transplantation. AMP-activated protein kinase (AMPK) is an energy sensitive kinase that plays crucial roles in the regulation of metabolic homeostasis. In HIRI, ischemia induces the decline of ATP and the increased ratio of AMP/ATP, which promotes the phosphorylation and activation of AMPK. Three AMPK kinases, liver kinase B1 (LKB1), Ca2+/calmodulin-depedent protein kinase kinase β (CaMKKβ) and TGF-β-activated kinase-1 (TAK1), are main upstream kinases for the phosphorylation of AMPK. In addition to the changed AMP/ATP ratio, the activated CaMKKβ by increased intracelluar Ca2+and the overproduction of reactive oxygen species (ROS) are also involved in the activation of AMPK during HIRI. The activated AMPK might provide protective benefits in HIRI via prevention of energy decline, inhibition of inflammatory response, suppression of hepatocyte apoptosis and attenuation of oxidative stress. Thus, AMPK might become a novel target for the pharmacological intervention of HIRI.
authors.affiliation: Department of Pathophysiology, Chongqing Medical University Chongqing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Pathophysiology, Chongqing Medical University Chongqing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: Hepatology Center, Xiamen Hospital of Traditional Chinese Medicine Xiamen, Fujian Province, China.
authors.forename: Xianqiong
authors.initials: X
authors.lastname: Gong
authors.affiliation: Department of Pathophysiology, Chongqing Medical University Chongqing, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Ge
authors.affiliation: Hospital of Chongqing University of Arts and Sciences Chongqing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Pathophysiology, Chongqing Medical University Chongqing, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Pathophysiology, Chongqing Medical UniversityChongqing, China; Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical UniversityChongqing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
keywords: AMP-activated protein kinase; apoptosis; hepatic ischemia-reperfusion injury; inflammation; oxidative stress