title: Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings.
abstract: Residual dipolar couplings (RDC) emerged to be an important structural parameter for organic and biomolecules. Herein, a new helical polyisocyanopeptide (l,l-PIAF-OBn) that forms lyotropic liquid crystals (LLC) in CDCl3is proposed as a novel weakly orienting medium for acquiring residual dipolar couplings (RDCs) of organic molecules. We demonstrate its application for the structural elucidation of strychnine and triptolide.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, P. R. China.
authors.forename: Gao-Wei
authors.initials: GW
authors.lastname: Li
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, P. R. China.
authors.forename: Jiang-Ming
authors.initials: JM
authors.lastname: Cao
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zong
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Hu
authors.affiliation: College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
authors.forename: Mao-Lin
authors.initials: ML
authors.lastname: Hu
authors.affiliation: School of Pharmaceutical Sciences, South Central University for Nationalities, Wuhan, 430074, P. R. China.|College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, 325035, P. R. China.
authors.forename: Xinxiang
authors.initials: X
authors.lastname: Lei
authors.affiliation: Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Roessle-Strasse 10, 13125, Berlin, Germany.
authors.forename: Han
authors.initials: H
authors.lastname: Sun
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, P. R. China.
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D004224:Diterpenes / Q000737:chemistry; D004852:Epoxy Compounds / Q000737:chemistry; D050866:Liquid Crystals / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry; D013331:Strychnine / Q000737:chemistry
chemical_list: D004224:Diterpenes; D004852:Epoxy Compounds; D010455:Peptides; D010616:Phenanthrenes; C001899:triptolide; D013331:Strychnine
keywords: NMR spectroscopy; liquid crystals; polyisocyanodipeptides; residual dipolar couplings; small organic molecules