title: Rituximab therapy in necrotizing autoimmune myopathy associated with anti-SRP antibody: A clinical case review.
abstract: Necrotizing autoimmune myopathy (NAM) is a rare and emerging entity of idiopathic inflammatory myopathy (IIM). They have been associated with connective tissue disorders, viral infections, malignancy, anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase protein (with or without the use of statins). Anti-SRP associated NAM has different clinical and histological characteristics that differentiate them from other IIM, resulting in a poor prognosis. Very few cases treated with rituximab have been published, with varying clinical response. Here we describe a case of anti-SRP associated NAM refractory to conventional immunosuppressants and its successful long-term management with the combination of rituximab, corticosteroids and methotrexate.
authors.affiliation: Servicio de Reumatología, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España. Electronic address: fnovmed@hotmail.es.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Nóvoa Medina
authors.affiliation: Servicio de Neurología, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: José
authors.initials: J
authors.lastname: Gutiérrez Martínez
authors.affiliation: Servicio de Radiodiagnóstico, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: Yeray
authors.initials: Y
authors.lastname: González González
authors.affiliation: Servicio de Radiodiagnóstico, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Romero Díaz
authors.affiliation: Servicio de Reumatología, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: Sergio
authors.initials: S
authors.lastname: Machín García
authors.affiliation: Servicio de Reumatología, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rosas Romero
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009220:Myositis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D000069283:Rituximab / Q000627:therapeutic use*; D018271:Signal Recognition Particle / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007166:Immunosuppressive Agents; D018271:Signal Recognition Particle; D000069283:Rituximab
keywords: Anti-signal recognition particle; Miopatías necrosantes autoinmunes; Necrotizing autoimmune myopathy; Partícula de reconocimiento de la señal; Rituximab