title: Enantioselective total synthesis of (+)-arborescidine C and related tetracyclic indole alkaloids using organocatalysis.
abstract: A concise and enantioselective synthesis of the tetracyclic indoles, including the naturally occurring compounds (+)-arborescidine C and (+)-arborescidine B, was achieved by the key step of Pictet-Spengler cyclization reaction with a Jacobsen-type thiourea organocatalyst. The synthetic process was further demonstrated in a pot-economy strategy and was achieved in a one-pot operation.
authors.affiliation: Department of Chemistry and Biochemistry, National Chung Cheng University, Chia-Yi 621, Taiwan, Republic of China. chebch@ccu.edu.tw.
authors.forename: Vishal M
authors.initials: VM
authors.lastname: Sheth
authors.forename: Bor-Cherng
authors.initials: BC
authors.lastname: Hong
authors.forename: Gene-Hsiang
authors.initials: GH
authors.lastname: Lee
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D026121:Indole Alkaloids; C483924:arborescidine C