title: From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2.
abstract: Zinc cluster proteins are a large family of transcriptional regulators with a wide range of biological functions. The zinc cluster proteins Ecm22, Upc2, Sut1 and Sut2 have initially been identified as regulators of sterol import in the budding yeastSaccharomyces cerevisiae. These proteins also control adaptations to anaerobic growth, sterol biosynthesis as well as filamentation and mating. Orthologs of these zinc cluster proteins have been identified in several species ofCandida. Upc2 plays a critical role in antifungal resistance in these important human fungal pathogens. Upc2 is therefore an interesting potential target for novel antifungals. In this review we discuss the functions, mode of actions and regulation of Ecm22, Upc2, Sut1 and Sut2 in budding yeast andCandida.
authors.affiliation: Division of Biosciences, Brunel University London, Uxbridge UB8 3PH, UK. ifeoluwapo.joshua@brunel.ac.uk.
authors.forename: Ifeoluwapo Matthew
authors.initials: IM
authors.lastname: Joshua
authors.affiliation: Division of Biosciences, Brunel University London, Uxbridge UB8 3PH, UK. thomas.hoefken@brunel.ac.uk.
authors.forename: Thomas
authors.initials: T
authors.lastname: Höfken
mesh_terms: D002176:Candida albicans / Q000737:chemistry / Q000378:metabolism*; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism; D008958:Models, Molecular; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D016335:Zinc Fingers
chemical_list: D005656:Fungal Proteins; D012097:Repressor Proteins; D014157:Transcription Factors
keywords: Candida; anaerobic; antifungal; budding yeast; filamentation; mating; sterol biosynthesis; sterol uptake; transcription factor; zinc cluster protein