title: Multiple cutaneous reticulohistiocytosis with T-cell large granular lymphocyte clonopathy.
abstract: A 63-year-old Caucasian man presented with a 4-month history of disseminated asymptomatic reddish-brown papulonodular lesions. A skin biopsy showed dermal infiltration with CD68+histiocytes, predominantly with eosinophilic cytoplasm, some with a ground-glass cytoplasm, and a small number of giant cells. The diagnosis of multiple cutaneous reticulohistiocytosis was made. Bone marrow immunophenotyping due to peripheral blood lymphocytosis revealed the presence of a monoclonal population of CD3+, CD8+CD57+large granular lymphocytes. The present case suggests the coexistence of multiple cutaneous reticulohistiocytosis with an underlying disorder.
authors.affiliation: Department of Dermatology, University General Hospital of Heraklion, Heraklion, Crete, Greece.
authors.forename: Pavlos
authors.initials: P
authors.lastname: Papadantonakis
authors.affiliation: Department of Haematology, University General Hospital of Heraklion, Heraklion, Crete, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Kaparou
authors.affiliation: Department of Haematology, University General Hospital of Heraklion, Heraklion, Crete, Greece.
authors.forename: Helen A
authors.initials: HA
authors.lastname: Papadaki
authors.affiliation: Department of Haematopathology, Evangelismos Hospital, Athens, Greece.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Marinos
authors.affiliation: Department of Dermatology, University General Hospital of Heraklion, Heraklion, Crete, Greece.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Krasagakis
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D017252:CD3 Complex / Q000378:metabolism; D018959:CD57 Antigens / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000145:classification* / Q000378:metabolism / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000175:diagnosis* / Q000473:pathology
chemical_list: D017252:CD3 Complex; D018959:CD57 Antigens
keywords: lymphoproliferative disease; multicentric reticulohistiocytosis; multiple cutaneous reticulohistiocytosis