title: The Promus Premier everolimus-eluting platinum chromium stent with durable polymer evaluated in a real world all-comer population in Rotterdam cardiology hospital (the P-SEARCH registry).
abstract: BACKGROUND
  A new-generation everolimus eluting platinum-chromium stent (EePCS), offering improved radial strength, radiopacity and conformability compared to everolimus-eluting cobalt-chromium stents (EeCCS), was evaluated with regard to safety and efficacy in an all-comer cohort.
  
  
  METHODS
  A total of 1000 consecutive all-comer patients (including acute coronary syndrome, multivessel disease, calcified lesions) treated with an EePCS (Promus Premier™, Boston Scientific, Natick, Massachusetts) from May 2013 to October 2014 were compared to 1000 consecutive patients treated with an EeCCS (Xience Prime™, Abbott Vascular, Santa Clara, California) from April 2012 to May 2013. Patients were clinically followed for 1year.
  
  
  RESULTS
  Mean age was 66±12years with diabetes in 20.7%, previous infarction in 22.7%, and ACS as the indication in 71.2% of patients. The mean number of stents per patient was 1.8±1.13. Total stented length was 35±25mm. Lesion classification was B2/C in 73.9% of patients. At 1year the primary endpoint of major adverse cardiac events (all-cause mortality, myocardial infarction [MI], ischemia-driven target vessel revascularization [TVR]) was reached in 11.7% in the EePCS cohort and 10.9% in the EeCCS cohort (adjusted HR 1.01 [0.77-1.33]; p=0.95). No significant differences were noted in the individual clinical endpoints all-cause mortality (6.8% versus 6.4%), MI (2.2% versus 2.3%), and TVR (4.3% versus 3.7%) in the respective EePCS and EeCCS cohorts. Stent thrombosis occurred in 0.8% and 1.0% respectively.
  
  
  CONCLUSIONS
  In all-comer patients undergoing percutaneous coronary intervention, the use of EePCS was associated with similar 1-year clinical outcome as compared to EeCCS.
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Miguel E
authors.initials: ME
authors.lastname: Lemmert
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Nicolas M
authors.initials: NM
authors.lastname: van Mieghem
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Robert-Jan
authors.initials: RJ
authors.lastname: van Geuns
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Roberto
authors.initials: R
authors.lastname: Diletti
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Rutger J
authors.initials: RJ
authors.lastname: van Bommel
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Ron T
authors.initials: RT
authors.lastname: van Domburg
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Peter P
authors.initials: PP
authors.lastname: de Jaegere
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Evelyn
authors.initials: E
authors.lastname: Regar
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Felix
authors.initials: F
authors.lastname: Zijlstra
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Eric
authors.initials: E
authors.lastname: Boersma
authors.affiliation: Thoraxcenter, Erasmus Medical Center, Rotterdam, Netherlands. Electronic address: j.daemen@erasmusmc.nl.
authors.forename: Joost
authors.initials: J
authors.lastname: Daemen
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000401:mortality / Q000601:surgery; D002857:Chromium; D015331:Cohort Studies; D054855:Drug-Eluting Stents / Q000592:standards* / Q000639:trends; D000068338:Everolimus / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality / Q000601:surgery; D009426:Netherlands / Q000453:epidemiology; D062645:Percutaneous Coronary Intervention / Q000592:standards* / Q000639:trends; D010984:Platinum; D011108:Polymers; D011446:Prospective Studies; D012042:Registries
chemical_list: D011108:Polymers; D002857:Chromium; D010984:Platinum; D000068338:Everolimus
keywords: All-comer registry; Cobalt-chromium stent; Drug eluting stent(s); Everolimus-eluting stent; Platinum-chromium stent