title: Identification of Mutagenic Aromatic Amines in River Samples with Industrial Wastewater Impact.
abstract: Aromatic amines are one of the most important classes of compounds contributing to surface water mutagenicity due to their widespread occurrence as precursors and transformation products of dyes, pharmaceuticals, agrochemicals, and other compound classes. In this study, we implemented a workflow including novel analytical and data evaluation methods aiming to identify aromatic amines in six mutagenic wastewater effluents from a chemical-industrial area in Germany, collected by the passive sampler Blue Rayon. We identified 14 amines including the two potent mutagenic aromatic amines 2,3- and 2,8-phenazinediamine, which were reported for the first time as environmental contaminants. These two isomers accounted between 4.2 and 86% of the mutagenicity of the blue rayon extracts and may be byproducts of dye production at the studied site.
authors.affiliation: Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15, 04318 Leipzig, Germany.|Department of Ecosystem Analyses, Institute for Environmental Research, RWTH Aachen University , Worringerweg 1, 52074 Aachen, Germany.
authors.forename: Melis
authors.identifier: 0000-0001-6510-5864
authors.initials: M
authors.lastname: Muz
authors.affiliation: Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15, 04318 Leipzig, Germany.
authors.forename: Janek Paul
authors.initials: JP
authors.lastname: Dann
authors.affiliation: Synchem UG & Co. KG, Am Kies 2, 34587 Felsberg-Altenburg, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Jäger
authors.affiliation: Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15, 04318 Leipzig, Germany.|Department of Ecosystem Analyses, Institute for Environmental Research, RWTH Aachen University , Worringerweg 1, 52074 Aachen, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Brack
authors.affiliation: Department Effect-Directed Analysis, Helmholtz Centre for Environmental Research - UFZ , Permoserstrasse 15, 04318 Leipzig, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Krauss
mesh_terms: D000588:Amines; D009152:Mutagenicity Tests; D009153:Mutagens; D045483:Rivers; D062065:Wastewater; D014874:Water Pollutants, Chemical
chemical_list: D000588:Amines; D009153:Mutagens; D062065:Wastewater; D014874:Water Pollutants, Chemical