title: The Impact of Weight on Arthroscopic Osteochondral Talar Reconstruction.
abstract: BACKGROUND
  The purpose of the study was to assess the functional and radiologic outcomes after AT-AMIC (arthroscopic talus autologous matrix-induced chondrogenesis) in 2 weight groups of patients with osteochondral lesions of the talus (OLTs): patients with BMI <25 (Healthy Weight Group [HG]) and with BMI ≥25 (Overweight Group [OG]).
  
  
  METHODS
  Thirty-seven patients were evaluated. HG was composed of 21 patients (BMI = 21.90 ± 1.94), whereas OG consisted of 16 patients (BMI = 27.41 ± 1.98). All patients were treated with AT-AMIC repair for OLTs. Magnetic resonance imaging (MRI), computed tomography (CT), Visual Analgoue Scale (VAS) for pain, American Orthopaedic Foot & Ankle Society (AOFAS) Ankle and Hindfoot score and Short-Form Health Survey (SF-12) were administered preoperatively (T0) and at 6 (T1), 12 (T2), and 24 (T3) months postoperatively.
  
  
  RESULTS
  In both groups, we found a significant difference for clinical and radiologic parameters with analysis of variance for repeated measures through 4 time points ( P < .001). In HG, AOFAS increased at every follow-up ( P < .05), whereas in OG, AOFAS improved only between T2and T3( P = .0104). In OG we found a significant difference comparing CT and MRI at each follow-up; in HG this difference was found only at T0( P < .0001) and T1( P = .0492). Finally, OG presented a significantly larger lesion measured with MRI at T0( P = .033).
  
  
  CONCLUSIONS
  OLTs in overweight patients were characterized by a larger preoperative size. At final follow-up, both groups showed a significant clinical improvement. AT-AMIC can be considered a safe and reliable procedure, regardless of weight, with a significant improvement also in quality of life.
  
  
  METHODS
  Level III, comparative study.
authors.affiliation: 1 IRCCS Istituto Ortopedico Galeazzi, UO CASCO, Piede e Caviglia, Milan, Italy.
authors.forename: Federico Giuseppe
authors.initials: FG
authors.lastname: Usuelli
authors.affiliation: 1 IRCCS Istituto Ortopedico Galeazzi, UO CASCO, Piede e Caviglia, Milan, Italy.|2 Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Maccario
authors.affiliation: 3 Università Vita-Salute San Raffaele, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Ursino
authors.affiliation: 4 Seconda Università degli Studi di Napoli, Naples, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Serra
authors.affiliation: 1 IRCCS Istituto Ortopedico Galeazzi, UO CASCO, Piede e Caviglia, Milan, Italy.|2 Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: D'Ambrosi
mesh_terms: D000843:Ankle Joint / Q000503:physiopathology*; D001182:Arthroscopy / Q000379:methods*; D001835:Body Weight / Q000502:physiology*; D002358:Cartilage, Articular / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D011788:Quality of Life; D013628:Talus / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology*
keywords: ankle arthroscopy; autologous matrix–induced chondrogenesis; body mass index; bone marrow edema; osteochondral talar lesions; quality of life