title: Retrospective Study Looking at Cinacalcet in the Management of Hyperparathyroidism after Kidney Transplantation.
abstract: Objectives.The primary objective of this study is to evaluate the use of cinacalcet in the management of hyperparathyroidism in kidney transplant recipients. The secondary objective is to identify baseline factors that predict cinacalcet use after transplantation.Methods.In this single-center retrospective study, we conducted a chart review of all patients having been transplanted from 2003 to 2012 and having received cinacalcet up to kidney transplantation and/or thereafter.Results.Twenty-seven patients were included with a mean follow-up of 2.9 ± 2.4 years. Twenty-one were already taking cinacalcet at the time of transplantation. Cinacalcet was stopped within the first month in 12 of these patients of which 7 had to restart therapy. The main reason for restarting cinacalcet was hypercalcemia. Length of treatment was 23 ± 26 months. There were only 3 cases of mild hypocalcemia. There was no statistically significant association between baseline factors and cinacalcet status a year later.Conclusions.Discontinuing cinacalcet within the first month of kidney transplantation often leads to hypercalcemia. Cinacalcet appears to be an effective treatment of hypercalcemic hyperparathyroidism in kidney transplant recipients. Further studies are needed to evaluate safety and long-term benefits.
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Habib
authors.initials: H
authors.lastname: Mawad
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Hugues
authors.initials: H
authors.lastname: Bouchard
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Duy
authors.initials: D
authors.lastname: Tran
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Denis
authors.initials: D
authors.lastname: Ouimet
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Jean-Philippe
authors.identifier: 0000-0001-7876-0446
authors.initials: JP
authors.lastname: Lafrance
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Robert Zoël
authors.initials: RZ
authors.lastname: Bell
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Bezzaoucha
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Anne
authors.initials: A
authors.lastname: Boucher
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Suzon
authors.initials: S
authors.lastname: Collette
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Vincent
authors.initials: V
authors.lastname: Pichette
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Lynne
authors.initials: L
authors.lastname: Senécal
authors.affiliation: Division of Nephrology, Maisonneuve-Rosemont Hospital and the Department of Medicine, University of Montreal, Montreal, QC, Canada.
authors.forename: Michel
authors.identifier: 0000-0002-4856-5057
authors.initials: M
authors.lastname: Vallée