title: Malaria Genomics in the Era of Eradication.
abstract: The first reference genome assembly for thePlasmodium falciparummalaria parasite was completed over a decade ago, and the impact of this and other genomic resources on malaria research has been significant. Genomic resources for other malaria parasites are being established, even asP. falciparumcontinues to be the focus of development of new genomic methods and applications. Here we review the impact and applications of genomic data on malaria research, and discuss future needs and directions as genomic data generation becomes less expensive and more decentralized. Specifically, we focus on how population genomic strategies can be utilized to advance the malaria eradication agenda.
authors.affiliation: Genome Sequencing and Analysis Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Neafsey
authors.affiliation: Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115.|Infectious Disease Initiative, Broad Institute of MIT and Harvard, Cambridge Massachusetts 02142.|School of Nursing and Health Sciences, Simmons College, Boston, MA 02115.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Volkman
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology; D035843:Biomedical Research / Q000639:trends; D060740:Disease Eradication; D014644:Genetic Variation; D018503:Genome, Protozoan / Q000235:genetics*; D023281:Genomics / Q000639:trends*; D006801:Humans; D008288:Malaria / Q000235:genetics / Q000469:parasitology / Q000517:prevention & control / Q000635:transmission; D010961:Plasmodium / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D000073336:Whole Genome Sequencing / Q000379:methods