title: Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris.
abstract: Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients.
authors.affiliation: Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.
authors.forename: Tomio
authors.initials: T
authors.lastname: Umemoto
authors.affiliation: Department of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko, Tochigi, 321-2593, Japan. tyasu@dokkyomed.ac.jp.
authors.forename: Takanori
authors.initials: T
authors.lastname: Yasu
authors.affiliation: Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.|Department of Internal Medicine, Nerima Hikarigaoka General Hospital, Nerima, Tokyo, 179-0072, Japan.
authors.forename: Kenshiro
authors.initials: K
authors.lastname: Arao
authors.affiliation: Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.
authors.forename: Nahoko
authors.initials: N
authors.lastname: Ikeda
authors.affiliation: Department of Cardiology, Dokkyo Medical University Nikko Medical Center, Nikko, Japan.
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Horie
authors.affiliation: Department of Cardiology, Dokkyo Medical University Nikko Medical Center, Nikko, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sugimura
authors.affiliation: Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.|Department of Internal Medicine, Nerima Hikarigaoka General Hospital, Nerima, Tokyo, 179-0072, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kawakami
authors.affiliation: Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Fujita
authors.affiliation: Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan.
authors.forename: Shin-Ichi
authors.initials: SI
authors.lastname: Momomura
mesh_terms: D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D018056:Hemorheology / Q000502:physiology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D017035:Pravastatin / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin
keywords: Angina pectoris; Endothelial function; Hemorheology; Postprandial; Statin