title: Peripheral Nerve Block as a Supplement to Light or Deep General Anesthesia in Elderly Patients Receiving Total Hip Arthroplasty: A Prospective Randomized Study.
abstract: Peripheral nerve block combined with general anesthesia is a preferable anesthesia method for elderly patients receiving hip arthroplasty. The depth of sedation may influence patient recovery. Therefore, we investigated the influence of peripheral nerve blockade and different intraoperative sedation levels on the short-term recovery of elderly patients receiving total hip arthroplasty.
  
  
  
  Patients aged 65 years and older undergoing total hip arthroplasty were randomized into 3 groups: a general anesthesia without lumbosacral plexus block group, and 2 general anesthesia plus lumbosacral plexus block groups, each with a different level of sedation (light or deep). The extubation time and intraoperative consumption of propofol, sufentanil, and vasoactive agent were recorded. Postoperative delirium and early postoperative cognitive dysfunction were assessed using the Confusion Assessment Method and Mini-Mental State Examination, respectively. Postoperative analgesia was assessed by the consumption of patient-controlled analgesics and visual analog scale scores. Discharge time and complications over a 30-day period were also recorded.
  
  
  
  Lumbosacral plexus block reduced opioid intake. With lumbosacral plexus block, intraoperative deep sedation was associated with greater intake of propofol and vasoactive agent. In contrast, patients with lumbosacral plexus block and intraoperative light sedation had lower incidences of postoperative delirium and postoperative cognitive decline, and earlier discharge readiness times. The 3 groups showed no difference in complications within 30 days of surgery.
  
  
  
  Lumbosacral plexus block reduced the need for opioids and offered satisfactory postoperative analgesia. It led to better postoperative outcomes in combination with intraoperative light sedation (high bispectral index).
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Mei
authors.forename: Hanning
authors.initials: H
authors.lastname: Zha
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Lu
authors.forename: Xinqi
authors.initials: X
authors.lastname: Cheng
authors.forename: Shishou
authors.initials: S
authors.lastname: Chen
authors.forename: Xuesheng
authors.initials: X
authors.lastname: Liu
authors.forename: Yuanhai
authors.initials: Y
authors.lastname: Li
authors.forename: Erwei
authors.initials: E
authors.lastname: Gu
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000768:Anesthesia, General / Q000379:methods; D019644:Arthroplasty, Replacement, Hip; D003072:Cognition Disorders / Q000453:epidemiology; D015897:Comorbidity; D003693:Delirium / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008161:Lumbosacral Region; D008297:Male; D009407:Nerve Block / Q000379:methods; D061646:Operative Time; D011183:Postoperative Complications / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid