title: Classic congenital adrenal hyperplasia.
abstract: Congenital adrenal hyperplasia is attributed to inherited enzyme defects in the adrenal cortex. The classical form results in reduced production of cortisol and aldosterone, accompanied by an increase in production of adrenal cortical androgens. This causes virilisation in girls, adrenocortical failure and early puberty in both sexes. This article describes the genetics, clinical picture, diagnostics and treatment.
authors.affiliation: Endokrinologisk avdeling Akershus universitetssykehus og Campus Ahus Institutt for klinisk medisin Universitetet i Oslo.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Nermoen
authors.affiliation: Medisinsk avdeling Haukeland universitetssykehus og Klinisk institutt 2 Universitetet i Bergen.
authors.forename: Eystein S
authors.initials: ES
authors.lastname: Husebye
authors.affiliation: Barne-og ungdomsklinikken Oslo universitetssykehus, Rikshospitalet *   Nåværende adresse: Frambu kompetansesenter for sjeldne diagnoser.
authors.forename: Anne Grethe
authors.initials: AG
authors.lastname: Myhre
authors.affiliation: Medisinsk avdeling Haukeland universitetssykehus og Klinisk institutt 2 Universitetet i Bergen.
authors.forename: Kristian
authors.initials: K
authors.lastname: Løvås
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology; D013255:Steroid 21-Hydroxylase / Q000235:genetics; D014770:Virilism / Q000209:etiology
chemical_list: D005938:Glucocorticoids; D013255:Steroid 21-Hydroxylase