title: Genome Sequence of the Fungal Strain 14919 Producing 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor FR901512.
abstract: Fungal strain 14919 was originally isolated from a soil sample collected at Mt. Kiyosumi, Chiba Prefecture, Japan. It produces FR901512, a potent and strong 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. The genome sequence of fungal strain 14919 was determined and annotated to improve the productivity of FR901512.
authors.affiliation: Biotechnology Labs, Astellas Pharma, Inc., Ibaraki, Japan hiroya.ito@astellas.com.|Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Itoh
authors.affiliation: Biotechnology Labs, Astellas Pharma, Inc., Ibaraki, Japan.|Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsui
authors.affiliation: Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.|Fermlab, Inc., Tokyo, Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Kumagai
authors.affiliation: Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.|National Institute of Genetics, Shizuoka, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Arita
authors.affiliation: Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.|Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Hokkaido, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Machida
authors.affiliation: Biotechnology Labs, Astellas Pharma, Inc., Ibaraki, Japan.|Technology Research Association of Highly Efficient Gene Design (TRAHED), Hokkaido, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Shibata