title: Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.
abstract: Messenger RNA (mRNA) modification provides an additional layer of gene regulation in cells. In this issue of Cancer Cell, Zhang et al. report that ALKBH5, a demethylase of the mRNA modification N6-methyladenosine, regulates proliferation and self-renewal of glioblastoma stem-like cells by modulating pre-mRNA stability and expression of the FOXM1 gene.
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Deobrat
authors.initials: D
authors.lastname: Dixit
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: drjeremyrich@gmail.com.
authors.forename: Jeremy N
authors.initials: JN
authors.lastname: Rich
authors.affiliation: Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: czhao@sbpdiscovery.org.
authors.forename: Jing Crystal
authors.initials: JC
authors.lastname: Zhao
mesh_terms: D063646:Carcinogenesis; D002471:Cell Transformation, Neoplastic; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D008745:Methylation; D012333:RNA, Messenger
chemical_list: D012333:RNA, Messenger