title: Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities.
abstract: BACKGROUND
  SnCl2·2H2O has been used as a convenient precatalyst for the one-pot and rapid synthesis of 2-substituted quinolines under ultrasound irradiation in water. The reaction involved a 3-component reaction of aniline, aldehydes, and ethyl 3,3-diethoxypropionate in the presence of aerial oxygen to give the desired products in good yields.
  
  
  CONCLUSIONS
  Several of these compounds showed antibacterial activities when tested against gram-positive and gram-negative species. One compound i.e. 4b showed promising activities across both the species.
authors.affiliation: Department of Chemistry, K.L. University, Vaddeswaram Guntur-522502, Andhra Pradesh, India.
authors.forename: A S G
authors.initials: ASG
authors.lastname: Prasad
authors.affiliation: Department of Chemistry, K.L. University, Vaddeswaram Guntur-522502, Andhra Pradesh, India.
authors.forename: T Bhaskara
authors.initials: TB
authors.lastname: Rao
authors.affiliation: Department of Chemistry and The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Rambabu
authors.affiliation: Department of Chemistry, Krishna University, Machilipatnam-521001, Andhra Pradesh, India.
authors.forename: Mandava V Basaveswara
authors.initials: MVB
authors.lastname: Rao
authors.affiliation: Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India.
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D017971:Tin Compounds / Q000737:chemistry*; D000069453:Ultrasonic Waves; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D011804:Quinolines; D017971:Tin Compounds; D014867:Water; C023599:stannous chloride; C037219:quinoline
keywords: Antibacterial; MCRs; SnCl2; quinoline; ultrasound; water.