title: Asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides with α,β-ynones: a straightforward approach to spirooxindoles incorporating 2,5-dihydropyrroles and pyrroles.
abstract: An organocatalytic asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides and α,β-ynones has been developed. This reaction afforded spiro[dihydropyrrole-2,3'-oxindole] products in high chemical yields with excellent stereoselectivities (up to 99% yields, >20 : 1 dr and >99% ee). Notably, a series of important spiro[pyrrole-oxindole] derivatives were readily obtained via oxidation of the cycloadducts, thus extending the diversity of the products.
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China. bmwang@dlut.edu.cn.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhu
authors.forename: Shiqi
authors.initials: S
authors.lastname: Wu
authors.forename: Xiaoze
authors.initials: X
authors.lastname: Bao
authors.forename: Longchen
authors.initials: L
authors.lastname: Cui
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jingping
authors.initials: J
authors.lastname: Qu
authors.forename: Hongbo
authors.initials: H
authors.lastname: Chen
authors.forename: Baomin
authors.initials: B
authors.lastname: Wang