title: Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid.
abstract: BACKGROUND
  It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no report on the effect of HSP70 and IL-8 on the blisters of burn patients.
  
  
  OBJECTIVE
  This study aimed to evaluate the serial quantitative changes of HSP70 and IL-8 in burn blisters.
  
  
  METHODS
  Twenty-five burn patients were included, for a total of 36 cases: twenty cases on the first day, six cases on the second, five cases on the third, three cases on the fourth, and two cases on the fifth. A correlation analysis was performed to determine the relationship between the concentration of HSP70 and IL-8 and the length of the treatment period.
  
  
  RESULTS
  The HSP70 concentration was the highest on the first day, after which it decreased down to near zero. Most HSP70 was generated during the first 12 hours after the burn accident. There was no correlation between the concentration of HSP70 on the first day and the length of the treatment period. No measurable concentration of IL-8 was detected before 5 hours, but the concentration started to increase after 11 hours. The peak value was measured on the fourth day.
  
  
  CONCLUSIONS
  While HSP70 increased in the first few hours and decreased afterwards, IL-8 was produced after 11 hours and increased afterward in burn blister fluid. These findings provide new evidence on serial changes of inflammatory mediators in burn blister fluid.
authors.affiliation: Department of Emergency Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Kicheol
authors.initials: K
authors.lastname: Yoo
authors.affiliation: Department of Emergency Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Kang Yeol
authors.initials: KY
authors.lastname: Suh
authors.affiliation: Department of Emergency Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Gi Hun
authors.initials: GH
authors.lastname: Choi
authors.affiliation: Department of Anesthesiology and Pain Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: In-Suk
authors.initials: IS
authors.lastname: Kwak
authors.affiliation: Department of Plasticsurgery, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Dong Kook
authors.initials: DK
authors.lastname: Seo
authors.affiliation: Department of Surgery, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Dohern
authors.initials: D
authors.lastname: Kym
authors.affiliation: Burn Institute, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Hyeon
authors.initials: H
authors.lastname: Yoon
authors.affiliation: Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Yong Se
authors.initials: YS
authors.lastname: Cho
authors.affiliation: Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Hye One
authors.initials: HO
authors.lastname: Kim
keywords: Heat-shock protein 70; Interleukin-8; Partial thickness burn; Partial thickness burn blister; Wounds and injuries