title: Iron Mapping in Multiple Sclerosis.
abstract: Increased iron deposition in cerebral deep gray matter has been considered a global marker for neurodegeneration in multiple sclerosis (MS); it scales with disease duration and severity. Iron accumulation in white matter and MS lesions might be more directly related to disease activity and has been discussed as a contributor to the inflammatory and neurodegenerative cascade. New insights into iron and MS are expected from MR imaging. We discuss findings from MR iron mapping proposed. Because of the confounding magnetic properties of myelin, iron mapping in white matter remains an unresolved issue.
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria. Electronic address: stefan.ropele@medunigraz.at.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ropele
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Enzinger
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Fazekas
mesh_terms: D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000378:metabolism*; D066127:White Matter
chemical_list: D007501:Iron
keywords: Biomarker; Ferritin; Iron; MR imaging; Magnetic susceptibility; Multiple sclerosis; Neurodegeneration