title: Office-based simple frailty score and central blood pressure predict mild cognitive impairment in an apparently healthy Japanese population: J-SHIPP study.
abstract: Frailty is associated with cognitive impairment and can be used to identify people at high risk for dementia. We developed a simple frailty (SF) score using a combination of low hand grip strength (<32.5 kg in men, <19.5 kg in women), and short one-leg standing time (<20 seconds). These can be easily measured in the clinician's office when seeing patients. We investigated the possible association between SF score and mild cognitive impairment (MCI) in a cross-sectional study with 838 independent middle-aged to elderly participants (319 men, mean age 65.1years). In total, 118 participants were diagnosed with MCI. A SF score of 2 was significantly associated with the presence of MCI (odds ratio 4.6, 95% confidence interval: 1.9-6.9, p = 0.0001) even after adjustment for age and sex. Stepwise regression analyses showed that a SF score of 2 was associated with the presence of MCI, independently of central pulse pressure and silent cerebral infarcts. These findings indicate that the SF score is a useful frailty parameter to predict MCI in an apparently independent population.
authors.affiliation: Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Maya
authors.initials: M
authors.lastname: Ohara
authors.affiliation: Faculty of Collaborative Regional Innovation, Ehime University, Ehime Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kohara
authors.affiliation: Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Okada
authors.affiliation: Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ochi
authors.affiliation: Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Tokihisa
authors.initials: T
authors.lastname: Nagai
authors.affiliation: Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Ohyagi
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.affiliation: Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Michiya
authors.initials: M
authors.lastname: Igase
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D001835:Body Weight; D001921:Brain / Q000000981:diagnostic imaging*; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D003430:Cross-Sectional Studies; D005260:Female; D000073496:Frailty / Q000453:epidemiology*; D015577:Geriatric Assessment / Q000379:methods*; D064368:Healthy Volunteers; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio