title: Ropivacaine versus levobupivacaine in peripheral nerve block: A PRISMA-compliant meta-analysis of randomized controlled trials.
abstract: BACKGROUND
  To determine which is more potent in peripheral nerve block between ropivacaine and levobupivacaine.
  
  
  METHODS
  A literature search was performed in the EMBASE, Medline, the Cochrane Library, and the Web of Science. The trials that were found were then evaluated for eligibility. The Cochrane Collaboration's Review Manager software was used to perform the meta-analyses.
  
  
  RESULTS
  Twelve studies including 556 patients were included for final analysis. No statistically significant difference was observed between the 2 drugs with respect to onset time of surgical anesthesia, onset time of sensory block, onset time of motor block, duration of motor block, and patients overall satisfaction. Levobupivacaine provided more long-term anesthesia (weighted mean difference [WMD], -2.94; 95% confidence interval [CI], -5.56 to -0.32; I = 93%) and significantly lower incidence of postoperative rescue analgesia (odds ratio [OR], 2.11; 95% CI 1.18-3.74; I = 21%) than ropivacaine. There was a trend toward greater duration of sensory block in the levobupivacaine group (WMD, -1.16; 95% CI, -1.89 to -0.43; I = 14%).
  
  
  CONCLUSIONS
  Levobupivacaine is more potent than ropivacaine in peripheral nerve block to some extent. Otherwise, more rigorous randomized control trials are required in the future.
authors.affiliation: Department of Orthopedics, Tianjin Medical University General Hospital, Heping District, Tianjin Department of Orthopaedics, Henan Provincial People's Hospital, Zhengzhou, China.
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Wei
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jiaxiao
authors.initials: J
authors.lastname: Shi
authors.forename: Han
authors.initials: H
authors.lastname: Ding
authors.forename: Haoshuai
authors.initials: H
authors.lastname: Tang
authors.forename: Pengyuan
authors.initials: P
authors.lastname: Zheng
authors.forename: Yanzheng
authors.initials: Y
authors.lastname: Gao
authors.forename: Shiqing
authors.initials: S
authors.lastname: Feng
mesh_terms: D000577:Amides; D000698:Analgesia; D000779:Anesthetics, Local; D002045:Bupivacaine / Q000031:analogs & derivatives*; D006801:Humans; D000077554:Levobupivacaine; D009407:Nerve Block; D017060:Patient Satisfaction; D016032:Randomized Controlled Trials as Topic; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D000077554:Levobupivacaine; D002045:Bupivacaine