title: Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.
abstract: We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques and experimental data. In the second part, it is further developed to account for the formation of solid aggregates in the flow and at the membrane surface. Simulations of various types of aggregates highlight the main benefits of discrete multi-physics and indicate the potential of this approach for coupling the hydrodynamics with phenomena such as clotting and calcification in biological valves.
authors.affiliation: School of Chemical Engineering, University of Birmingham, Birmingham, United Kingdom.
authors.forename: Mostapha
authors.initials: M
authors.lastname: Ariane
authors.affiliation: INSA Euro-Méditerranée, Université Euro-Méditerranéenne de Fès, Fez, Morocco.
authors.forename: Mohamed Hatem
authors.initials: MH
authors.lastname: Allouche
authors.affiliation: LivaNova-Sorin, Saluggia, Vercelli, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bussone
authors.affiliation: LivaNova-Sorin, Saluggia, Vercelli, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Giacosa
authors.affiliation: Laboratoire Interdisciplinaire Carnot de Bourgogne, Université de Bourgogne Franche-Comté, Dijon, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bernard
authors.affiliation: School of Chemical Engineering, University of Birmingham, Birmingham, United Kingdom.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Barigou
authors.affiliation: School of Chemical Engineering, University of Birmingham, Birmingham, United Kingdom.
authors.forename: Alessio
authors.initials: A
authors.lastname: Alexiadis
mesh_terms: D001775:Blood Circulation; D001807:Blood Vessel Prosthesis; D057446:Hydrodynamics; D008955:Models, Cardiovascular