title: A highly enantioselective Friedel-Crafts reaction of 3,5-dimethoxylphenol with nitroolefins mediated by a bifunctional quinine derived thiourea catalyst.
abstract: A useful enantioselective Friedel-Crafts reaction of 3,5-dimethoxylphenol with nitroolefins catalyzed by a bifunctional quinine derived thiourea catalyst 9 was developed. The Michael addition products could be obtained in good to high yields (68-92%) and with excellent enantioselectivities (89-98% ee). Such a reaction is exceptionally attractive in virtue of its simple protocol, ready availability of the starting materials, and practical applications of the products.
authors.affiliation: Zhejiang Provincial Key Laboratory for Chemical & Biological Processing Technology of Farm Products, School of Biological and Chemical Engineering/School of Light Industry, Zhejiang University of Science and Technology, Hangzhou, 310023, China. chemhanxy@zust.edu.cn yjwang@zust.edu.cn.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Han
authors.forename: Can
authors.initials: C
authors.lastname: Ye
authors.forename: Fenfen
authors.initials: F
authors.lastname: Chen
authors.forename: Qu
authors.initials: Q
authors.lastname: Chen
authors.forename: Yongjiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zeng
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry; D011803:Quinine / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000475:Alkenes; C015155:phloroglucinol dimethyl ether; D011803:Quinine; D010696:Phloroglucinol; D013890:Thiourea