title: TLRgeting Evasion of Immune Pathways in Glioblastoma.
abstract: Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. (2016) now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.
authors.affiliation: Unit of Molecular Neuro-Oncology, Foundation IRCCS Neurological Institute Carlo Besta, 20133 Milan, Italy. Electronic address: gaetano.finocchiaro@istituto-besta.it.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Finocchiaro
mesh_terms: D001932:Brain Neoplasms; D005909:Glioblastoma / Q000276:immunology*; D006801:Humans; D014411:Neoplastic Stem Cells; D015398:Signal Transduction