title: Parathyroid Hormone-Related Peptide: A Novel Endocrine Cardioprotective "Conditioning Mimetic".
abstract: An as-yet limited body of evidence suggests that calcium-regulating endocrine hormones-in particular, parathyroid hormone-related peptide (PTHrP)-may have unappreciated cardioprotective effects. The current review focuses on the concept that PTHrP may, via modulation of classic cardioprotective signaling pathways, provide a novel strategy to attenuate myocardial ischemia-reperfusion injury.
authors.affiliation: 1 Department of Internal Medicine, George Washington University, Washington, DC, USA.
authors.forename: Tanuka
authors.initials: T
authors.lastname: Datta
authors.affiliation: 2 Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, USA.|3 Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA.|4 Department of Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Karin
authors.initials: K
authors.lastname: Przyklenk
authors.affiliation: 2 Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI, USA.|5 Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Nabanita S
authors.initials: NS
authors.lastname: Datta
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000494:pharmacology / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control; D044162:Parathyroid Hormone-Related Protein / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D002316:Cardiotonic Agents; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein
keywords: heart; ischemia; mitogen-activated protein kinase phosphatase 1; parathyroid hormone–related peptide; reperfusion