title: Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole.
abstract: OBJECTIVE
  Ovarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as estrogen and progesterone receptors (ER/PR).
  
  
  METHODS
  A 29-year-old woman presented with incidental finding of large bilateral adnexal masses and elevated CA 125. Biopsy proved anaplastic ovarian ependymoma with high ER/PR expression. She underwent sub-optimal surgical debulking followed by adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP) which resulted in a partial response. Due to extensive residual disease she has been maintained on anastrozole for over fifteen months without increased tumor burden. Targeted somatic mutation testing was negative for all high risk clinically useful variants.
  
  
  CONCLUSIONS
  Aromatase inhibitors may be considered in patients with extra-axial anaplastic ependymoma and can produce prolonged stable disease.
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Unit 1362, P.O. Box 301439, Houston, TX 77230-1439, USA.
authors.forename: Justin Wayne
authors.initials: JW
authors.lastname: Gorski
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Unit 1362, P.O. Box 301439, Houston, TX 77230-1439, USA.
authors.forename: Jolyn Sharpe
authors.initials: JS
authors.lastname: Taylor
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 0085, Houston, TX 77230-1439, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 0085, Houston, TX 77230-1439, USA.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Unit 1362, P.O. Box 301439, Houston, TX 77230-1439, USA.
authors.forename: Amir Anthony
authors.initials: AA
authors.lastname: Jazaeri
keywords: Aromatase inhibitor; Ovarian anaplastic ependymoma