title: Yangonindimers A-C, three new kavalactone dimers from Piper methysticum (kava).
abstract: Three new kavalactone dimers, designated as yangonindimers A-C (1-3), along with one known analogue were isolated from the roots of Piper methysticum. Their structures were elucidated via extensive analysis of their 1D, 2D NMR and mass spectroscopic data. All these dimers possess a skeleton featuring a cyclobutane ring connecting two kavalactone units. Compounds 1-4 were evaluated for their cytotoxic activities against human tumour cell lines NCI-H46, SW480 and HepG2, but none showed significant activity.
authors.affiliation: a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , China.|b College of Life Sciences , University of Chinese Academy of Sciences , Beijing , China.
authors.forename: Jia-Ling
authors.initials: JL
authors.lastname: Song
authors.affiliation: a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , China.|b College of Life Sciences , University of Chinese Academy of Sciences , Beijing , China.
authors.forename: Bai-Lin
authors.initials: BL
authors.lastname: Li
authors.affiliation: a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , China.|b College of Life Sciences , University of Chinese Academy of Sciences , Beijing , China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: c College Of Traditional Chinese Medicine , Southern Medical University , Guangzhou , China.
authors.forename: Ling-Hui
authors.initials: LH
authors.lastname: Nie
authors.affiliation: a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , China.|b College of Life Sciences , University of Chinese Academy of Sciences , Beijing , China.
authors.forename: Jia
authors.initials: J
authors.lastname: Niu
authors.affiliation: d Intern , High School Junior of Davis Senior High School , Davis , CA , USA.
authors.forename: David
authors.initials: D
authors.lastname: Chiu
authors.affiliation: a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , China.
authors.forename: Zhi-Fang
authors.initials: ZF
authors.lastname: Xu
authors.affiliation: a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , China.
authors.forename: Jie-Wei
authors.identifier: http://orcid.org/0000-0003-0555-6086
authors.initials: JW
authors.lastname: Wu
authors.affiliation: a Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization , South China Botanical Garden, Chinese Academy of Sciences , Guangzhou , China.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Qiu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D003503:Cyclobutanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D020901:Kava / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D003503:Cyclobutanes; D007783:Lactones; C000625598:yangonindimer A; C000625599:yangonindimer B; C000625600:yangonindimer C
keywords: Kavalactone dimers; Piper methysticum; cytotoxic activities; yangonindimers A-C