title: Evaluation of Skeletal Muscle Function in Lung Transplant Candidates.
abstract: Lung transplantation (LTx) is offered to older and more complex patients who may be at higher risk of skeletal muscle dysfunction, but the clinical implications of this remain uncertain. The study aims were to characterize deficits in skeletal muscle mass, strength and physical performance, and examine the associations of these deficits with clinical outcomes.
  
  
  
  Fifty LTx candidates (58% men; age, 59 ± 9 years) were prospectively evaluated for skeletal muscle deficits: muscle mass using bioelectrical impedance, quadriceps, respiratory muscle and handgrip strength, and physical performance with the Short Physical Performance Battery. Comparisons between number of muscle deficits (low muscle mass, quadriceps strength and physical performance) and 6-minute walk distance (6MWD), London Chest Activity of Daily Living Questionnaire, and quality of life were assessed using one-way analysis of variance. Associations with pretransplant and posttransplant delisting/mortality, hospital duration, and 3-month posttransplant 6MWD were evaluated using Fisher exact test and Spearman correlation.
  
  
  
  Deficits in quadriceps strength (n = 27) and physical performance (n = 24) were more common than muscle mass (n = 8). LTx candidates with 2 or 3 muscle deficits (42%) compared with those without any deficits (26%) had worse 6MWD = -109 m (95% confidence interval [CI], -175 to -43), London Chest Activity of Daily Living Questionnaire = 18 (95% CI, 7-30), and St. George's Activity Domain = 12 (95% CI, 2-21). Number of muscle deficits was associated with posttransplant hospital stay (r = 0.34, P = 0.04), but not with delisting/mortality or posttransplant 6MWD.
  
  
  
  Deficits in quadriceps muscle strength and physical performance are common in LTx candidates and further research is needed to assess whether modifying muscle function pretransplant can lead to improved clinical outcomes.
authors.affiliation: 1 Department of Medicine, Respirology, University of Toronto, Toronto, ON, Canada. 2 Lung Transplant Program, University Health Network, Toronto, ON, Canada. 3 Critical Care, University Health Network, Toronto, ON, Canada. 4 Respirology, West Park Health Care Center, Toronto, ON, Canada. 5 Department of Physical Therapy, University of Toronto, Toronto, ON, Canada.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Rozenberg
authors.forename: Lianne G
authors.initials: LG
authors.lastname: Singer
authors.forename: Margaret
authors.initials: M
authors.lastname: Herridge
authors.forename: Roger
authors.initials: R
authors.lastname: Goldstein
authors.forename: Lisa
authors.initials: L
authors.lastname: Wickerson
authors.forename: Noori A
authors.initials: NA
authors.lastname: Chowdhury
authors.forename: Sunita
authors.initials: S
authors.lastname: Mathur
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D017079:Exercise Tolerance; D005260:Female; D018737:Hand Strength; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology / Q000601:surgery*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D053580:Muscle Strength; D009929:Organ Size; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D052097:Quadriceps Muscle / Q000473:pathology / Q000503:physiopathology*; D011788:Quality of Life; D012132:Respiratory Muscles / Q000473:pathology / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D000070857:Walk Test