title: Mercury, omega-3 fatty acids, and seafood intake are not associated with heart rate variability or QT interval.
abstract: Mercury (Hg), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) concentrations differ across seafood types. Our aim was to investigate the association of Hg, EPA, and DHA, as well as avid consumption of diverse seafood types, with cardiovascular variables heart rate variability (HRV) and QT interval duration (QTc) in a contemporary population. We measured HRV and QTc by Holter monitor, EPA and DHA in plasma, total Hg in whole blood, and possible confounders in 94 avid seafood consumers from Long Island, NY. Participants had mean Hg of 8.4 mcg/L, mean EPA of 1.2%, and mean DHA of 3.7% of total fatty acids. Adjusted for possible confounders, EPA+DHA, Hg, and total seafood consumption were not associated with HRV or QTc. Associations with consumption of specific seafood types were suggested (eg, tuna steak with QTc and anchovies with HRV) but require verification.
authors.affiliation: a Department of Medicine , Stony Brook University School of Medicine , Stony Brook , New York , USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Miller
authors.affiliation: b School of Marine and Atmospheric Science , Stony Brook University , Stony Brook , New York , USA.
authors.forename: Roxanne
authors.initials: R
authors.lastname: Karimi
authors.affiliation: b School of Marine and Atmospheric Science , Stony Brook University , Stony Brook , New York , USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Silbernagel
authors.affiliation: c Stony Brook University School of Medicine , Stony Brook , New York , USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Kostrubiak
authors.affiliation: d Department of Emergency Medicine , Stony Brook University School of Medicine , Stony Brook , New York , USA.
authors.forename: Frederick
authors.initials: F
authors.lastname: Schiavone
authors.affiliation: e US Food and Drug Administration , Center for Veterinary Medicine , Silver Spring , Maryland , USA.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: f Department of Family, Population, and Preventive Medicine , Stony Brook University School of Medicine , Stony Brook , New York , USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: g Division of Cardiology, Electrophysiology Section, Department of Medicine , Stony Brook University School of Medicine , Stony Brook , New York , USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Rashba
authors.affiliation: f Department of Family, Population, and Preventive Medicine , Stony Brook University School of Medicine , Stony Brook , New York , USA.|h Stony Brook University Program in Public Health , Stony Brook , New York , USA.
authors.forename: Jaymie R
authors.initials: JR
authors.lastname: Meliker
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004032:Diet; D004281:Docosahexaenoic Acids / Q000097:blood*; D015118:Eicosapentaenoic Acid / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008628:Mercury / Q000097:blood*; D008875:Middle Aged; D009518:New York; D017747:Seafood / Q000706:statistics & numerical data*
chemical_list: D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D008628:Mercury
keywords: Cardiovascular; DHA; EPA; fish