title: Chemical Modification of Cyclodextrin and Amylose by Click Reaction and Its Application to the Synthesis of Poly-alkylamine-Modified Antibacterial Sugars.
abstract: Cyclodextrin (CD) can be chemically modified into desired and sophisticated functional molecules. However, poly-modification often produces complicated mixtures, resulting in a low yield of the desired product. As the most promising procedure to solve such problems and to achieve poly-modification of the CD molecule, we present here the Huisgen 1,3-dipolar cycloaddition, known as a click reaction. This review will describe the results of our microwave-assisted click reaction for the poly-modification of CD and amylose molecules, and its application to the study of synthetic membrane active antibacterial derivatives.
authors.affiliation: Life Science and Applied Chemistry, Graduate School of Engineering,  Nagoya Institute of Technology.
authors.forename: Hatsuo
authors.initials: H
authors.lastname: Yamamura
mesh_terms: D000688:Amylose / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry*; D057930:Click Chemistry; D061565:Cycloaddition Reaction; D003505:Cyclodextrins / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D003505:Cyclodextrins; D011073:Polyamines; D000688:Amylose