title: Association of serum uric acid with increased risk of cancer among hypertensive Chinese.
abstract: Several large prospective studies show an association between serum uric acid (SUA) and cancer, however there is a lack of evidence in China. We aimed to investigate the effects of SUA levels on cancer incidence and mortality in China. This study included 20,577 adult hypertensive patients with valid SUA measurements who participated in the China Stroke Primary Prevention Trial where subjects were randomly assigned to receive a double-blind treatment of either 10 mg enalapril (n = 10,286) or 10.8 mg enalapril-folic acid (n = 10,291). Subjects were prospectively followed for a median of 4.5 years. Cox proportional hazards models were used to calculate hazards ratios (HR) of cancer risk associated with SUA. A total of 232 participants developed cancer. SUA was independently associated with increased cancer risk in the enalapril group [HR: 1.12, (95% CI: 1.03-1.22)]. Compared to the lowest tertile, combined subjects with SUA levels from the upper two tertiles had a higher risk of cancer in the enalapril group [T2 + T3: HR: 1.58, (95% CI: 1.02-2.47)]. In cancer site-specific analyses, a positive association of SUA levels with digestive cancer and all fatal cancer was also observed [HR: 1.18, (95% CI: 1.09-1.27); HR: 1.15, (95% CI: 1.03-1.28), respectively] in the enalapril group. Interestingly, SUA levels were not associated with the risk of cancer or related mortality in the enalapril folic acid group. Our results suggest that elevated SUA is independently and positively associated with the risk of total cancer incidence, digestive cancer incidence and cancer mortality among hypertensive Chinese.
authors.affiliation: National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Juan
authors.identifier: 0000-0002-2520-0768
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Sun Yat-Sen University Cancer Center, Collaborative Innovation center for Cancer medicine, Guangzhou, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Xianglin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Xianhui
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Radiology, Sun Yat-Sen University Cancer Center, Collaborative Innovation center for Cancer medicine, Guangzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing Cancer Hospital, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Oncology, First People's Hospital, Lianyungang, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Oncology, Second People's Hospital, Lianyungang, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lei
authors.affiliation: National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Binyan
authors.initials: B
authors.lastname: Wang
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Colorectal Surgery, Peking University Cancer Hospital and Institute, Peking-Tsinghua Center for Life Sciences, Beijing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Gu
authors.affiliation: National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Fan Fan
authors.initials: FF
authors.lastname: Hou
authors.affiliation: Department of Cardiology, Peking University First Hospital, No. 8 Xishiku St, Xicheng District, Beijing, 100034, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
authors.affiliation: Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
authors.forename: Xiping
authors.identifier: 0000-0002-3821-9257
authors.initials: X
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000473:pathology; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Chinese; cancer incidence; cancer mortality; hypertension; serum uric acid