title: Combined Effect of Obesity and Mobility Limitation with Incidence of Type 2 Diabetes and Mortality in Chinese Elderly.
abstract: This article aims to examine the effect of mobility limitation and obesity on the risk of new incidence of type 2 diabetes mellitus (T2DM) and mortality. The design was a cohort study (n = 1075) among adults aged 60 years and older. Obesity was defined as body-mass index greater than or equal to 28 kg/m2. Mobility limitation was defined as participants scoring in the top 20% on the timed up and go test or in the slowest 20% for the 4-m walking test. The mean age of the study population was 67.4 ± 5.4 years (age range: 60-86 years), and 57.4% were women. Overall, 5.1% of women and 1.9% of men had both obesity and mobility limitations. During 3-year follow-up, the new incidence of T2DM was 2.98% and the adjusted risk of the new incidence of T2DM was progressively greater in obese subjects without mobility limitation, but not greater in the single mobility limitation subjects. The combination of mobility limitation and obesity (odds ratio = 10.3, 95% confidence interval = 2.25-70.13) has a significantly higher risk than obesity only or mobility limitation only. What is more, obesity with mobility limitation could be an independent predictor of 3-year mortality compared with the other subjects. We demonstrated the associations between obesity and mobility limitation and thus the increased risk of developing, with the combination over time, T2DM and mortality.
authors.affiliation: 1 Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University , Tianjin, China .|2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Li
authors.initials: L
authors.lastname: Kang
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Liye
authors.initials: L
authors.lastname: Jia
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Peipei
authors.initials: P
authors.lastname: Han
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Liyuan
authors.initials: L
authors.lastname: Fu
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Hairui
authors.initials: H
authors.lastname: Yu
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Chen
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Lin
authors.initials: L
authors.lastname: Hou
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Xing
authors.initials: X
authors.lastname: Yu
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Jianing
authors.initials: J
authors.lastname: Song
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Ruiming
authors.initials: R
authors.lastname: He
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Tingting
authors.initials: T
authors.lastname: Miao
authors.affiliation: 2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Yang
authors.affiliation: 3 Nutritional Epidemiology Institute, Tianjin Medical University , Tianjin, China .|4 School of Public Health, Tianjin Medical University , Tianjin, China .
authors.forename: Kaijun
authors.initials: K
authors.lastname: Niu
authors.affiliation: 5 Department of Rehabilitation Medicine, Tianjin Hospital , Tianjin, China .
authors.forename: Liancheng
authors.initials: L
authors.lastname: Wang
authors.affiliation: 1 Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University , Tianjin, China .|2 Department of Rehabilitation Medicine, Tianjin Medical University , Tianjin, China .
authors.forename: Qi
authors.initials: Q
authors.lastname: Guo
mesh_terms: D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000401:mortality*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D009765:Obesity / Q000150:complications* / Q000401:mortality*; D016016:Proportional Hazards Models
keywords: T2DM; mobility limitation; obesity