title: Building Capability for Clinical Pharmacology Research in Sub-Saharan Africa.
abstract: A strong scientific rationale exists for conducting clinical pharmacology studies in target populations because local factors such as genetics, environment, comorbidities, and diet can affect variability in drug responses. However, clinical pharmacology studies are not widely conducted in sub-Saharan Africa, in part due to limitations in technical expertise and infrastructure. Since 2012, a novel public-private partnership model involving research institutions and a pharmaceutical company has been applied to developing increased capability for clinical pharmacology research in multiple African countries.
authors.affiliation: Novartis Pharma and Novartis Institutes for Biomedical Research, Basel, Switzerland and Cambridge, Massachusetts, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Gutierrez
authors.affiliation: Novartis Pharma and Novartis Institutes for Biomedical Research, Basel, Switzerland and Cambridge, Massachusetts, USA.
authors.forename: G
authors.initials: G
authors.lastname: Pillai
authors.affiliation: Novartis Pharma and Novartis Institutes for Biomedical Research, Basel, Switzerland and Cambridge, Massachusetts, USA.
authors.forename: S
authors.initials: S
authors.lastname: Felix
authors.affiliation: Novartis Pharma and Novartis Institutes for Biomedical Research, Basel, Switzerland and Cambridge, Massachusetts, USA.
authors.forename: F
authors.initials: F
authors.lastname: Romero
authors.affiliation: Kenya Medical Research Institute (KEMRI)/Strathmore University (SU), Nairobi, Kenya.
authors.forename: K O
authors.initials: KO
authors.lastname: Onyango
authors.affiliation: Kintampo Health Research Center, Kintampo, Ghana.
authors.forename: S
authors.initials: S
authors.lastname: Owusu-Agyei
authors.affiliation: Kintampo Health Research Center, Kintampo, Ghana.
authors.forename: K P
authors.initials: KP
authors.lastname: Asante
authors.affiliation: University of Cape Town, Cape Town, South Africa.
authors.forename: K I
authors.initials: KI
authors.lastname: Barnes
authors.affiliation: University of Cape Town, Cape Town, South Africa.
authors.forename: P
authors.initials: P
authors.lastname: Sinxadi
authors.affiliation: University of Cape Town, Cape Town, South Africa.
authors.forename: E
authors.initials: E
authors.lastname: Allen
authors.affiliation: Ifakara Health Institute, Bagamoyo, Tanzania.
authors.forename: S
authors.initials: S
authors.lastname: Abdulla
authors.affiliation: African Institute of Biomedical Science & Technology, Harare, Zimbabwe.
authors.forename: C
authors.initials: C
authors.lastname: Masimirembwa
authors.affiliation: African Institute of Biomedical Science & Technology, Harare, Zimbabwe.
authors.forename: M
authors.initials: M
authors.lastname: Munyoro
authors.affiliation: Addis Ababa University/Regional Bioequivalence Center, Addis Ababa, Ethiopia.
authors.forename: G
authors.initials: G
authors.lastname: Yimer
authors.affiliation: Addis Ababa University/Regional Bioequivalence Center, Addis Ababa, Ethiopia.
authors.forename: T
authors.initials: T
authors.lastname: Gebre-Mariam
authors.affiliation: Novartis Pharma and Novartis Institutes for Biomedical Research, Basel, Switzerland and Cambridge, Massachusetts, USA.
authors.forename: J
authors.initials: J
authors.lastname: Spector
authors.affiliation: Kenya Medical Research Institute (KEMRI)/Strathmore University (SU), Nairobi, Kenya.
authors.forename: B
authors.initials: B
authors.lastname: Ogutu
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D035843:Biomedical Research / Q000379:methods / Q000639:trends*; D002986:Clinical Trials as Topic / Q000379:methods; D006801:Humans; D007391:International Cooperation; D010597:Pharmacogenetics / Q000379:methods / Q000639:trends; D010601:Pharmacology, Clinical / Q000379:methods / Q000639:trends*; D055818:Public-Private Sector Partnerships / Q000639:trends*