title: Gleason Score within Prostate Abnormal Areas Defined by Multiparametric Magnetic Resonance Imaging Did Not Vary According to the PIRADS Score.
abstract: BACKGROUND
  We aim to correlate multiparametric magnetic resonance imaging (mpMRI) of the prostate reporting (Prostate Imaging Reporting and Data System [PI-RADS] version 2) with the Gleason score into both radical prostatectomy (RP) specimen and MRI fusion-targeted biopsies (FTB).
  
  
  METHODS
  mpMRI of 74 patients who underwent an RP after FTB were retrospectively reviewed. The Gleason score distribution was compared according to the PI-RADS score using the Kruskal-Wallis test. Results were compared to those of the mpMRI-guided biopsy of the same anatomical zone. For comparison, 903 RP specimen and their corresponding classical biopsies were also reviewed. Cohen's kappa concordance test was used to compare biopsies and prostatectomy specimen analyses.
  
  
  RESULTS
  An exact match between Gleason grade in RP specimen and FTB was found in 62% of the cases. There was no significant difference in Gleason score ≤7 (3 + 4) vs. ≥7 (4 + 3) distribution according to the PI-RADS scores (p = 0.096). Overall, Kappa coefficients were similar with MRI-targeted biopsies compared to classical biopsies (κ = 0.378, 95% CI [0.194-0.563], and κ = 0.316, 95% CI [0.259-0.374], respectively).
  
  
  CONCLUSIONS
  PI-RADS score was not associated with significant differences regarding Gleason score distribution within target. Moreover, concordance of Gleason score in both MRI-targeted and classical biopsies with those within target in RP specimen was weak.
authors.affiliation: Department of Urology, Hospital Foch, Suresnes, France.
authors.forename: Hakim
authors.initials: H
authors.lastname: Slaoui
authors.forename: Yann
authors.initials: Y
authors.lastname: Neuzillet
authors.forename: Tarek
authors.initials: T
authors.lastname: Ghoneim
authors.forename: Mathieu
authors.initials: M
authors.lastname: Rouanne
authors.forename: Abdelali
authors.initials: A
authors.lastname: Abdou
authors.forename: Pierre Marie
authors.initials: PM
authors.lastname: Lugagne-Delpon
authors.forename: Antoine
authors.initials: A
authors.lastname: Scherrer
authors.forename: Camelia
authors.initials: C
authors.lastname: Radulescu
authors.forename: Christian
authors.initials: C
authors.lastname: Delancourt
authors.forename: Vincent
authors.initials: V
authors.lastname: Molinié
authors.forename: Thierry
authors.initials: T
authors.lastname: Lebret
mesh_terms: D000368:Aged; D001706:Biopsy; D003661:Decision Support Techniques; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011237:Predictive Value of Tests; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies
keywords: Gleason; Magnetic resonance imaging; Prostate cancer; Radical prostatectomy; Targeted biopsy