title: Sarcopenia is associated with disability status-results from the KORA-Age study.
abstract: We estimated the prevalence of sarcopenia and its impact on disability in older people. Sarcopenia was found to contribute to higher disability scores. However, our study was not able to show any influence of sarcopenia on the rate of functional decline. This directs attention to an accurate diagnosis of sarcopenia as the onset may be influenced, but its rate may not.
  
  
  
  The objectives of this study using data from a population-based cohort were to estimate the prevalence of sarcopenia in older people in Germany and to test the hypothesis that sarcopenia is associated with disability in older adults.
  
  
  
  Cross-sectional (n = 927) and longitudinal analyses (n = 859) of participants aged ≥65 years at baseline from southern Germany enrolled in the Cooperative Health Research in the Region Augsburg (KORA)-Age study (2009-2012). Sarcopenia was defined based on the European Working Group on Sarcopenia in Older People (EWGSOP) algorithm which includes the presence of both low muscle mass and low muscle function (strength or performance). Disability status was measured by the Health Assessment Questionnaire-Disability Index (HAQ-DI). The presence of disability was defined as HAQ-DI >0. Directed acyclic graphs (DAGs) were constructed to identify potential confounders. The effect of sarcopenia on disability was analyzed using linear mixed effect models with disability values as a continuous outcome.
  
  
  
  The overall prevalence of sarcopenia was 5.7% (men 4.0%, women 7.5%) and increased with age. The 3-year incidence of disability was 32.7%. After adjustment for potential confounders, presence of sarcopenia was significantly associated with higher disability scores (0.142 [confidence interval 0.029-0.254]).
  
  
  
  The prevalence of sarcopenia is consistent with estimates from other European studies using this algorithm. Our results suggest that sarcopenia can contribute to higher disability scores in older adults. However, our study was not able to show any influence of sarcopenia on the rate of functional decline using the EWGSOP diagnostic algorithm for sarcopenia. This directs attention to an accurate diagnosis of sarcopenia as the onset may be influenced, but its rate may not.
authors.affiliation: Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany. amanda.phillips@med.uni-muenchen.de.|German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-Universität München, Munich, Germany. amanda.phillips@med.uni-muenchen.de.
authors.forename: A
authors.identifier: http://orcid.org/0000-0002-2510-2690
authors.initials: A
authors.lastname: Phillips
authors.affiliation: Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany.|German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Strobl
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Munich, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Vogt
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Munich, Germany.|Department for Psychosomatic Medicine and Psychotherapy, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
authors.forename: K-H
authors.initials: KH
authors.lastname: Ladwig
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Munich, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Thorand
authors.affiliation: Institute for Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany.|German Center for Vertigo and Balance Disorders, Ludwig-Maximilians-Universität München, Munich, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Grill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D006233:Persons with Disabilities / Q000706:statistics & numerical data*; D005260:Female; D005684:Gait / Q000502:physiology; D015577:Geriatric Assessment / Q000379:methods; D005858:Germany / Q000453:epidemiology; D018737:Hand Strength / Q000502:physiology; D006306:Health Surveys; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D015995:Prevalence; D055948:Sarcopenia / Q000453:epidemiology* / Q000503:physiopathology / Q000534:rehabilitation; D012680:Sensitivity and Specificity; D012959:Socioeconomic Factors
keywords: Disability; EWGSOP; Muscle mass; Older people; Sarcopenia