title: Independent validation of the adjusted GAPSS: Role of thrombotic risk assessment in the real-life setting.
abstract: Objective The objective of this report is to independently validate the adjusted Global Antiphospholipid Syndrome Score (aGAPSS) to predict thrombosis in a cohort of patients with APS and/or autoimmune disease. Methods This retrospective cohort study included 319 consecutive patients with APS and/or autoimmune disease. Data on clinical manifestations, conventional cardiovascular risk factors and aPL profile were collected. The aGAPSS was calculated for each patient by adding together the points corresponding to the risk factors. Results Among the 319 patients included (mean age: 48.0; SD 15.47), conducted over a mean period of 52 months (range: 19-394), 219 fulfilled the current APS classification criteria (PAPS diagnosed in 130 patients and APS associated autoimmune disease (aAPS) in 89 patients), and 100 patients with autoimmune disease without APS (AD). A total of 201 patients (63.0%) had a history of one or several thrombotic manifestations, 189 (86.3%) of them APS patients: 118 PAPS (mean age: 50.14; SD 15.47) and 71 aAPS (mean age: 48.13; SD 15.81). Higher aGAPSS baseline values were seen in patients with thrombosis 6.58 (SD 3.36) when compared with those without 4.90 (SD 4.33) ( p = 0.001). Conclusions This study has shown that even when anti-phosphatidylserine/prothrombin antibodies (aPS/PT) are not computed in an adjusted model of GAPSS (aGAPSS), this score represents an improvement in assessment of the risk prediction of thrombosis in APS patients and/or autoimmune disease. However, cut-off values may differ from other kinds of cohorts, which suggests that baseline characteristics in divergent groups of patients can account for differences in cut-off values of GAPSS.
authors.affiliation: 1 Department of Hematology, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Fernandez Mosteirin
authors.affiliation: 2 Department of Internal Medicine, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Saez Comet
authors.affiliation: 1 Department of Hematology, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Salvador Osuna
authors.affiliation: 1 Department of Hematology, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Calvo Villas
authors.affiliation: 2 Department of Internal Medicine, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Velilla Marco
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology*
chemical_list: D017152:Antibodies, Antiphospholipid
keywords: Antiphospholipid antibodies; autoimmune disease; lupus anticoagulant; thrombosis