title: SCA31 Flies Perform in a Balancing Act between RAN Translation and RNA-Binding Proteins.
abstract: In this issue of Neuron, Ishiguro et al. (2017) explore the toxicity of RAN translation in spinocerebellar ataxia 31. Using a Drosophila model, the authors demonstrate that TDP-43 and other RNA-binding proteins act as chaperones to regulate the formation of toxic RNA aggregates.
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, TX 77006, USA. Electronic address: grjackso@bcm.edu.
authors.forename: George R
authors.initials: GR
authors.lastname: Jackson
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D012313:RNA; D016601:RNA-Binding Proteins; D020754:Spinocerebellar Ataxias / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins; D012313:RNA
keywords: Drosophila; RNA chaperone; TDP-43; ataxia