title: Daidzein plus isolase associated with zinc improves clinical symptoms and quality of life in patients with LUTS due to benign prostatic hyperplasia: Results from a phase I-II study.
abstract: OBJECTIVE
  In the last years there is a growing interest in nutraceutical substances that seems able to improve clinical symptoms in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). In this paper, we evaluated both efficacy and safety of a combination of daidzein with isolase and zinc in patients with LUTS due to BPH.
  
  
  METHODS
  In a phase I-II study clinical trial we enrolled patients with clinical and instrumental diagnosis of LUTS associated to BPH that received a six-month treatment with a combination of daidzein with isolase and zinc (1 tablet/day). Clinical, laboratory and instrumental analyses were carried out at the time of admission (T0) and 6 months after the ending of the treatment (T1). The Italian version of International Prostatic Symptom Score (IPSS), International Index of Erectile Function (IIEF-5) and Quality of Well-Being (QoL) questionnaires were used. The development of adverse drug reactions (ADRs) and drug interactions (DDIs) were recorded using the Naranjo scale and drug interaction probability scale. Student's t test and Anova test were used for statistical analysis, and the threshold of statistical significance was set at P &lt; 0.05.
  
  
  RESULTS
  We enrolled 71 patients, 62 (87.3%) completed the follow-up and we documented a significant differences between T0 and T1 in terms of IPSS [21.5 ± 1.2 vs 16.2 ± 1.5; (-4.8); p &lt; 0.001], Cmax [9.7 ± 3.7 vs 15.3 ± 2.5; (+5.6); p &lt; 0.001] and QoL [0.56 ± 0.15 vs 0.84 ± 0.19; (+0.28); p &lt; 0.001]. In contrast, no significant difference were recorded in terms of IIEF-5 [p = 0.50] and PSA [p = 0.67]. Finally, we did not record any significant ADRs or DDIs during the study.
  
  
  CONCLUSIONS
  In this study, we documented that a combination of daidzein with isolase and zinc, reduces the clinical symptoms of LUTS and improves the quality of life in patients with BPH, without the development of ADRs or DDIs.
authors.affiliation: Department of Urology, Santa Chiara Regional Hospital, Trento. daniele.tiscione@apss.tn.it.
authors.forename: Daniele
authors.initials: D
authors.lastname: Tiscione
authors.forename: Luca
authors.initials: L
authors.lastname: Gallelli
authors.forename: Irene
authors.initials: I
authors.lastname: Tamanini
authors.forename: Lorenzo Giuseppe
authors.initials: LG
authors.lastname: Luciani
authors.forename: Paolo
authors.initials: P
authors.lastname: Verze
authors.forename: Alessandro
authors.initials: A
authors.lastname: Palmieri
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Mirone
authors.forename: Riccardo
authors.initials: R
authors.lastname: Bartoletti
authors.forename: Gianni
authors.initials: G
authors.lastname: Malossini
authors.forename: Tommaso
authors.initials: T
authors.lastname: Cai
mesh_terms: D000368:Aged; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage* / Q000009:adverse effects; D007558:Italy; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009930:Organic Chemicals / Q000008:administration & dosage* / Q000009:adverse effects; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D011788:Quality of Life; D016896:Treatment Outcome; D015032:Zinc / Q000008:administration & dosage*
chemical_list: D007529:Isoflavones; D009930:Organic Chemicals; C000633006:isolase; C004742:daidzein; D015032:Zinc