title: East Meets West-Impact of Ethnicity on Donor Match Rates in the Ezer Mizion Bone Marrow Donor Registry.
abstract: HLA haplotype frequencies in a volunteer bone marrow donor registry should reflect the frequencies of potential transplant recipients served by that registry, a challenge in a country with diverse subethnicities of immigrants from Eastern and Western cultures, such as Israel. We evaluated the likelihood of finding suitable donors for hypothetical patients drawn from defined subethnicities in the Ezer Mizion Bone Marrow Donor Registry (EM BMDR) from donors both within and outside the registry now and during the coming decade. On average, bioinformatics modeling predicts that, given current donor recruitment trends, 6/6 high-resolution HLA match rates for Israelis, which currently stand at 40% to 55% for most subethnicities, will rise by up to 1% per year over the next decade. Subethnicities with historically lower rates of interethnic admixture are less likely to find matches outside of their designated group but will benefit from expansion of the registry, whereas ethnically directed drives will enhance matching rates for currently underrepresented subethnicities. Donor searches for the same cohort using a large extramural registry was of only slight benefit for most of the 19 EM BMDR subethnicities evaluated, confirming that local donor registries that reflect the ethnic diversity of the community being served are best equipped to serve the needs of their respective communities. Contemporary trends of an increasingly multiethnic admixture in Israel may impact the effect of ethnic profiling in assessing future match rates for EM BMDR.
authors.affiliation: Bioinformatics Research, National Marrow Donor Program, Minneapolis, Minnesota. Electronic address: mhalagan@nmdp.org.
authors.forename: Michael
authors.initials: M
authors.lastname: Halagan
authors.affiliation: Ezer Mizion Bone Marrow Donor Registry, Petah-Tikva, Israel.
authors.forename: Sigal
authors.initials: S
authors.lastname: Manor
authors.affiliation: Ezer Mizion Bone Marrow Donor Registry, Petah-Tikva, Israel.
authors.forename: Nira
authors.initials: N
authors.lastname: Shriki
authors.affiliation: Ezer Mizion Bone Marrow Donor Registry, Petah-Tikva, Israel; Bone Marrow Transplant Unit, Schneider Children's Medical Center of Israel, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Isaac
authors.initials: I
authors.lastname: Yaniv
authors.affiliation: Ezer Mizion Bone Marrow Donor Registry, Petah-Tikva, Israel.
authors.forename: Bracha
authors.initials: B
authors.lastname: Zisser
authors.affiliation: Bioinformatics Research, National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Abeer
authors.initials: A
authors.lastname: Madbouly
authors.affiliation: Bioinformatics Research, National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Martin
authors.initials: M
authors.lastname: Maiers
authors.affiliation: Bone Marrow Transplant Unit, Schneider Children's Medical Center of Israel, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Jerry
authors.initials: J
authors.lastname: Stein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D046148:Donor Selection; D005260:Female; D006680:HLA Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012042:Registries; D014019:Tissue Donors
chemical_list: D006680:HLA Antigens
keywords: Bone marrow donor registry; HLA; Haplotype and allele frequencies; Jewish population; Match rates; Registry modeling