title: Inappropriate implantable cardioverter-defibrillator shocks in Brugada syndrome: Pattern in primary and secondary prevention.
abstract: BACKGROUND
  Inappropriate implantable cardioverter-defibrillator (ICD) shocks is a common complication in Brugada syndrome. However, the incidence in recipients of ICD for primary and secondary prevention is unknown.
  
  
  RESULTS
  We compared the rate of inappropriate shocks in patients with Brugada syndrome that had an ICD for primary and secondary prevention. We studied 51 patients, 86.5% of whom were males. Their mean age at diagnosis was 47 ± 11 years. Eighteen (35%) were asymptomatic, while 25 (49%) experienced syncope prior to implantation. Eight (16%) patients were resuscitated from ventricular fibrillation before implantation. During a mean follow-up of 78 ± 46 months, none of the asymptomatic patients experienced appropriate therapy, whereas 21.6% of symptomatic patients had ≥1 shock. Inappropriate shock occurred in 7 (13.7%) patients, with a mean IS of 6.57 ± 6.94 shocks per patient occurring 16.14 ± 10.38 months after implantation. There was a trend towards higher incidence of inappropriate shock in the asymptomatic group (p = 0.09). The interval from implantation to inappropriate shock occurrence was 13.91 ± 12.98 months. The risk of IS at 3 years was 13.7%, which eventually plateaued over the time.
  
  
  CONCLUSIONS
  Inappropriate shock is common in Brugada syndrome during the early periods after an ICD implantation, and seems to be more likely in asymptomatic patients. This finding may warrant a review of the indications for ICD implantation, especially in the young and apparently healthy population of patients with Brugada syndrome.
authors.affiliation: Clinique Paul Picquet, Service de cardiologie, Sens, France. Electronic address: aimebonny@yahoo.fr.
authors.forename: Aimé
authors.initials: A
authors.lastname: Bonny
authors.affiliation: Department of Internal Medicine, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Talle
authors.affiliation: Centre Hospitalier d'Aix en Provence, Service de cardiologie, Aix en Provence, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Vaugrenard
authors.affiliation: Centre Hospitalier d'Aix en Provence, Service de cardiologie, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Taieb
authors.affiliation: Statprest, Biostatistics Unit, Paris, France.
authors.forename: Marcus
authors.initials: M
authors.lastname: Ngantcha
keywords: Brugada syndrome; Implantable cardioverter-defibrillator; Inappropriate shock