title: Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode.
abstract: As artificial prostheses become more refined, they are most often used as a therapeutic option for hand amputation. By contrast to extra- or intraneural interfaces, regenerative nerve electrodes are designed to enable electrical interfaces with regrowing axonal bundles of injured nerves, aiming to achieve high selectivity for recording and stimulation. However, most of the developed designs pose an obstacle to the regrowth mechanisms due to low transparency and cause impairment to the nerve regeneration.
  
  
  
  Here we present the double-aisle electrode, a new type of highly transparent, non-obstructive regenerative electrode. Using a double-side thin-film polyimide planar multi-contact electrode, two nerve fascicles can regenerate without physical impairment through two electrically isolated aisles.
  
  
  
  We show that this electrode can be used to selectively record and stimulate fascicles, acutely as well as chronically, and allow regeneration in nerve gaps of several millimeters without impairment.
  
  
  
  This multi-aisle regenerative electrode may be suitable for neuroprosthetic applications, such as prostheses, for the restoration of hand function after amputation or severe nerve injuries.
authors.affiliation: Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Delgado-Martínez
authors.forename: M
authors.initials: M
authors.lastname: Righi
authors.forename: D
authors.initials: D
authors.lastname: Santos
authors.forename: A
authors.initials: A
authors.lastname: Cutrone
authors.forename: S
authors.initials: S
authors.lastname: Bossi
authors.forename: S
authors.initials: S
authors.lastname: D'Amico
authors.forename: J
authors.initials: J
authors.lastname: Del Valle
authors.forename: S
authors.initials: S
authors.lastname: Micera
authors.forename: X
authors.initials: X
authors.lastname: Navarro
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D004567:Electrodes, Implanted; D005260:Female; D008839:Microelectrodes; D008904:Miniaturization / Q000379:methods*; D009416:Nerve Regeneration / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley