title: Persistence of a t(11;14)-positive clone in a patient with mantle cell lymphoma for 20 years.
abstract: We report here a patient with extremely indolent mantle cell lymphoma (MCL) who had progressed and required immunochemotherapy 20 years after diagnostic splenectomy. Non-nodal, indolent MCL patients may progress after such an extraordinary long indolent phase, and we recommend lifelong follow up for such cases.
authors.affiliation: Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Otsuka
authors.affiliation: Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan.
authors.forename: Momoko
authors.identifier: 0000-0003-4171-2162
authors.initials: M
authors.lastname: Nishikori
authors.affiliation: Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kitano
authors.affiliation: Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Oka
authors.affiliation: Department of Hematology Kobe City Medical Center General Hospital Kobe Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ishikawa
authors.affiliation: Department of Pathology Kyoto University Hospital Kyoto Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Haga
authors.affiliation: Department of Hematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan.
authors.forename: Akifumi
authors.initials: A
authors.lastname: Takaori-Kondo
keywords: Cyclin D1; Sox11; Splenectomy; mantle cell lymphoma; somatic hypermutation analysis