title: Cyclic ether synthesis from diols using trimethyl phosphate.
abstract: Cyclic ethers have been effectively synthesized via the intramolecular cyclization of diols using trimethyl phosphate and NaH. The present cyclization could proceed at room temperature to produce 5-7 membered cyclic ethers in good to excellent yields. Substrates possessing a chiral secondary hydroxy group were transformed into the corresponding chiral cyclic ethers along with the retention of their stereochemistries.
authors.affiliation: Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan. sajiki@gifu-pu.ac.jp sawama@gifu-pu.ac.jp.
authors.forename: Shota
authors.initials: S
authors.lastname: Asai
authors.forename: Maho
authors.initials: M
authors.lastname: Kato
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Monguchi
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Sawama