title: Prostate organogenesis: tissue induction, hormonal regulation and cell type specification.
abstract: Prostate organogenesis is a complex process that is primarily mediated by the presence of androgens and subsequent mesenchyme-epithelial interactions. The investigation of prostate development is partly driven by its potential relevance to prostate cancer, in particular the apparent re-awakening of key developmental programs that occur during tumorigenesis. However, our current knowledge of the mechanisms that drive prostate organogenesis is far from complete. Here, we provide a comprehensive overview of prostate development, focusing on recent findings regarding sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation.
authors.affiliation: Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
authors.forename: Roxanne
authors.initials: R
authors.lastname: Toivanen
authors.affiliation: Departments of Medicine, Genetics and Development, Urology, and Systems Biology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA mshen@columbia.edu.
authors.forename: Michael M
authors.identifier: 0000-0002-4042-1657
authors.initials: MM
authors.lastname: Shen
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004848:Epithelium / Q000196:embryology; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D038081:Organogenesis; D011467:Prostate / Q000033:anatomy & histology / Q000166:cytology* / Q000196:embryology*; D012727:Sex Characteristics
chemical_list: D006728:Hormones
keywords: Androgen signaling; Development; Differentiation; Induction; Prostate