title: Electronic cigarettes: age-specific generation-resolved pulmonary doses.
abstract: Particle size-number distributions of aerosol from e-cigarettes (0 and 14 mg mL-1nicotine) were compared with conventional cigarettes. Results were used to provide age-specific (9-21 years) dosimetry estimates applying the MMPD model. After a 2-s puff, total number doses (DTot) were highest for 9 years of age (6.01 × 1010-1.31 × 1011particles) and lowest for 18 years of age (4.69 × 1010-1.06 × 1011particles). Such doses represented about 19-45 and 25-100% of the relevant daily doses of not smoking individuals, respectively, in tracheobronchial (TB) and alveolar (A) regions. DTotfor the e-cigarettes were about double that for conventional cigarette. Deposition densities and daily volume of e-cigarette liquid deposited per unit surface area were maximum at lobar bronchi, highest for 9 years and lowest for 21 years age.
authors.affiliation: DIT, INAIL Settore Ricerca, Certificazione e Verifica, via R. Ferruzzi 38/40, 00133, Rome, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Manigrasso
authors.affiliation: Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, via Di Biasio 43, 03043, Cassino, Italy.|Queensland University of Technology, Brisbane, Australia.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Buonanno
authors.affiliation: Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, via Di Biasio 43, 03043, Cassino, Italy.
authors.forename: Fernanda Carmen
authors.initials: FC
authors.lastname: Fuoco
authors.affiliation: Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, via Di Biasio 43, 03043, Cassino, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Stabile
authors.affiliation: DIT, INAIL Settore Ricerca, Certificazione e Verifica, via R. Ferruzzi 38/40, 00133, Rome, Italy. p.avino@inail.it.|Department of Agriculture, Environment and Food, University of Molise, via De Sanctis, 86100, Campobasso, Italy. p.avino@inail.it.
authors.forename: Pasquale
authors.identifier: http://orcid.org/0000-0003-4030-7624
authors.initials: P
authors.lastname: Avino
mesh_terms: D000336:Aerosols; D066300:Electronic Nicotine Delivery Systems; D006801:Humans; D008168:Lung; D009538:Nicotine; D010316:Particle Size; D012907:Smoking
chemical_list: D000336:Aerosols; D009538:Nicotine
keywords: Aerosol; Age-specific; Deposition dose; E-cigarette; Human respiratory system; MPPD