title: Alginate-polyvinyl alcohol based interpenetrating polymer network for prolonged drug therapy, Optimization and in-vitro characterization.
abstract: A new natural and synthetic polymeric blend to form interpenetrating polymer network (IPN) hydrogels was synthesized utilizing sodium alginate and PVA as polymers by free radical polymerization employing 2-Acylamido-2-methylpropane-sulfonic acid as monomer (AMPS) and tramadol HCl as model drug through 32level full factorial design to evaluate the impact of selected independent factors i.e. polymer (sodium alginate) and monomer (AMPS) contents on swelling index at 18th hour, percent drug release at 18th hour, time required for 80% drug release and drug entrapment efficiency as dependent variables. FTIR, SEM, sol-gel analysis, equilibrium swelling studies and in-vitro release kinetics were performedfor in-vitro characterization of formulated IPN hydrogels. In-vitro studies carried out at pH 1.2 and pH 7.4 revealed pH independent swelling and drug release from polymeric IPN, providing controlled drug release for an extended period of time with improved entrapment efficiency, thereby concluding that this polymeric blend may be a promising system for the prolonged drug delivery.
authors.affiliation: Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur 63100, Punjab, Pakistan.
authors.forename: Hina
authors.initials: H
authors.lastname: Anwar
authors.affiliation: Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur 63100, Punjab, Pakistan. Electronic address: ma786_786@yahoo.com.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Ahmad
authors.affiliation: Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur 63100, Punjab, Pakistan.
authors.forename: Muhammad Usman
authors.initials: MU
authors.lastname: Minhas
authors.affiliation: Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur 63100, Punjab, Pakistan.
authors.forename: Sahrish
authors.initials: S
authors.lastname: Rehmani
mesh_terms: D000464:Alginates / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D006603:Hexuronic Acids; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D011108:Polymers; D011142:Polyvinyl Alcohol / Q000737:chemistry*
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D020100:Hydrogels; D011108:Polymers; D011142:Polyvinyl Alcohol
keywords: AMPS [PubChem65360]; EGDMA [PubChem CID:7355]; Interpenetrating polymer network; Na-alginate [PubChem CID: 6850754]; PVA [PubChem CID: 11199]; Prolonged drug delivery; Release kinetics; SHS [PubChem CID: 23665763]; Sodium alginate; Swelling index; TramadolHCl[PubChemCID: 63013]