title: Tamoxifen-Dependent Induction of AGR2 Is Associated with Increased Aggressiveness of Endometrial Cancer Cells.
abstract: Tamoxifen treatment in breast cancer patients is associated with increased risk of endometrial malignancies. Significantly, higher AGR2 expression was found in endometrial cancers that developed in women previously treated with tamoxifen compared to those who had not been exposed to tamoxifen. An association of elevated AGR2 level with myometrial invasion occurrence and invasion depth was also found. In vitro analyses identified a stimulatory effect of AGR2 on cellular proliferation. Although adverse tamoxifen effects on endometrial cells remain elusive, our work identifies elevated AGR2 as a candidate tamoxifen-dependent mechanism of action responsible for increased incidence of endometrial cancer.
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Hrstka
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Podhorec
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Nenutil
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Lucia
authors.initials: L
authors.lastname: Sommerova
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Joanna
authors.initials: J
authors.lastname: Obacz
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Durech
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Faktor
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Bouchal
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Skoupilova
authors.affiliation: a Masaryk Memorial Cancer Institute , RECAMO , Brno , Czech Republic.
authors.forename: Borivoj
authors.initials: B
authors.lastname: Vojtesek
mesh_terms: D000072283:A549 Cells; D000230:Adenocarcinoma / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018931:Antineoplastic Agents, Hormonal / Q000633:toxicity*; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D016889:Endometrial Neoplasms / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D004717:Endometrium / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D009088:Mucoproteins; D009361:Neoplasm Invasiveness; D015513:Oncogene Proteins; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D012189:Retrospective Studies; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects; D013629:Tamoxifen / Q000633:toxicity*; D014162:Transfection; D015854:Up-Regulation
chemical_list: C502296:AGR2 protein, human; D018931:Antineoplastic Agents, Hormonal; D009088:Mucoproteins; D015513:Oncogene Proteins; D011506:Proteins; D013629:Tamoxifen
keywords: AGR2; Breast cancer; Endometrial cancer; Tamoxifen