title: Ventricular Tachycardia as a Complication of Ledipasvir and Sofosbuvir Treatment for HCV Infection.
abstract: We experienced two patients with serious arrhythmias associated with the administration of ledipasvir (LDV) and sofosbuvir (SOF). Neither patient took amiodarone, an agent for which concomitant use is prohibited. One patient was 82 years old and hypertensive; the other was 72 years old and had no cardiovascular risk factors such as hypertension or diabetes mellitus. The arrhythmias were both serious ventricular tachycardia (VT) that converted spontaneously to sinus rhythm, without treatment, and both patients had good outcomes. These cases suggest that LDV/SOF may be associated with an increased risk of heart-related events.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Japan.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Nirei
authors.forename: Hitomi
authors.initials: H
authors.lastname: Nakamura
authors.forename: Shunichi
authors.initials: S
authors.lastname: Matsuoka
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Yamana
authors.forename: Shunichi
authors.initials: S
authors.lastname: Yoda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirayama
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Moriyama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005449:Fluorenes / Q000009:adverse effects* / Q000627:therapeutic use; D006526:Hepatitis C / Q000188:drug therapy*; D006801:Humans; D012307:Risk Factors; D000069474:Sofosbuvir / Q000009:adverse effects* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000139:chemically induced*
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D005449:Fluorenes; C586541:ledipasvir; D000069474:Sofosbuvir