title: Default mode and task-positive networks connectivity during the N-Back task in remitted depressed patients with or without emotional residual symptoms.
abstract: Clinical remission of depression may be associated with emotional residual symptoms. We studied the association of emotional blunting, rumination with neural networks dynamics in remitted depressed patients and cognitive performance during an N-Back task. Twenty-six outpatients in remission of depression (Hamilton Depressive rating scale score <7) performed an N-Back task during fMRI assessment. All patients had been treated by paroxetine for a minimum of 4 months. Two subgroups of patients [Nonemotionally blunted (NEB) = 14 and emotionally blunted (EB) = 12] were determined. To identify functional network maps across participants, the Network Detection using Independent Component Analysis approach was employed. Within and between Task Positive Network (TPN) and Default Mode Network (DMN) connectivity were assessed and related to variability of performance on the N-Back task and rumination. EB and NEB patients were not different for the level of accurate responses at the N-Back. However over the entire working memory task, the negative correlation between DMN and TPN was significantly lower in the EB than NEB group and was differently related to cognitive performance and rumination. The stronger the negative correlation between DMN and TPN was, the less variable the reaction time during 3-Back task in NEB patients. Moreover the greater the negative correlation between DMN and TPN was, the lower the rumination score in EB patients. Emotional blunting may be associated with compromised monitoring of rumination and cognitive functioning in remitted depressed patients through altered cooperation between DMN and TPN. The study suggests clinical remission in depression is associated with biological heterogeneity. Hum Brain Mapp 38:3491-3501, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du cerveau et de la moelle (ICM)-Hôpital Pitié Salpêtrière, Boulevard de l'hôpital, Paris, France.
authors.forename: Pauline
authors.identifier: http://orcid.org/0000-0001-8640-8581
authors.initials: P
authors.lastname: Delaveau
authors.affiliation: Department of Radiology, Universidade Federal do Rio de Janeiro, Medical School, Rio de Janeiro, Brazil.
authors.forename: Tiago
authors.initials: T
authors.lastname: Arruda Sanchez
authors.affiliation: Department of Psychiatry, Clinical Research Center in Psychiatry, Hospital Santa Casa de Misericórdia do Rio de Janeiro, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Steffen
authors.affiliation: Institut de Recherches Internationales Servier, Suresnes, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Deschet
authors.affiliation: Institut de Recherches Internationales Servier, Suresnes, France.
authors.forename: Maritza
authors.initials: M
authors.lastname: Jabourian
authors.affiliation: IHU-A-ICM, Bioinformatics/Biostatistics Plateform, Paris, France.|INSERM U1146, CNRS UMR7371, laboratoire d'imagerie biomédicale, Sorbonne université, UPMC université, Paris 60 UMCR2, Hôpital de la Pitié-Salpêtrière, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Perlbarg
authors.affiliation: Department of Radiology, Universidade Federal do Rio de Janeiro, Medical School, Rio de Janeiro, Brazil.
authors.forename: Emerson Leandro
authors.initials: EL
authors.lastname: Gasparetto
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du cerveau et de la moelle (ICM)-Hôpital Pitié Salpêtrière, Boulevard de l'hôpital, Paris, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Dubal
authors.affiliation: Institut Brésilien du Cerveau, INBRACER, RJ, Brazil, Université Catholique de Rio de Janeiro, Brazil.
authors.forename: Jorge
authors.initials: J
authors.lastname: Costa E Silva
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du cerveau et de la moelle (ICM)-Hôpital Pitié Salpêtrière, Boulevard de l'hôpital, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Fossati
keywords: depressive disorder; fMRI; neural networks; task performance; working memory