title: Assessment of the immunogenicity of gonadotrophins during controlled ovarian stimulation.
abstract: OBJECTIVE
  Gonadotrophin hormones are used for the controlled ovarian stimulation (COS) as part of the in vitro fertilization techniques. Therapeutic proteins have the potential to induce an unwanted immune response.
  
  
  METHODS
  The presence of anti-FSH, anti-LH and anti-hCG antibodies were determined in patients from two different clinical trials after the repeated administration of hMG or FSH.
  
  
  RESULTS
  In the first study, 27 subjects were screening for the presence of anti-FSH antibodies. From the 27 patients, only one patient showed the presence of low levels of antibodies. In a second study, 25 patients were screened for the presence of anti-FSH, anti-LH and anti-hCG antibodies. At the end of the study, no patients showed the presence of antibodies.
  
  
  CONCLUSIONS
  The results of this study suggest that repeated treatment cycles with FSH or hMG in patients undergoing COS for in vitro fertilization can be safely and effectively applied without concerns for immunogenicity.
authors.affiliation: Kymos Pharma Services, Parc Tecnològic del Valles, Barcelona, Spain.
authors.forename: Carles
authors.identifier: http://orcid.org/0000-0003-4509-1228
authors.initials: C
authors.lastname: Morte
authors.affiliation: Kymos Pharma Services, Parc Tecnològic del Valles, Barcelona, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Celma
authors.affiliation: Klinik für gyn. Endokrinologie und Reproduktionsmedizin, University of Basel, Basel, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: De Geyter
authors.affiliation: Division of Assisted Reproduction, First Department of Ob/Gyn, Semmelweis University, Budapest, Hungary.
authors.forename: Janos
authors.initials: J
authors.lastname: Urbancsek
authors.affiliation: Department of Obstet-Gynec.-Reproduction, Institut Universitari Dexeus, Barcelona, Spain.
authors.forename: Buenaventura
authors.initials: B
authors.lastname: Coroleu Lletget
authors.affiliation: IBSA Institut Biochimique SA, Pambio-Noranco, Switzerland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Cometti
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000276:immunology*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral; D007986:Luteinizing Hormone / Q000276:immunology*; D010062:Ovulation Induction; D011446:Prospective Studies; D013030:Spain
chemical_list: D000906:Antibodies; D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: 
  FSH
  ; 
  LH
  ; 
  hCG
  ; ADA; antibodies