title: The emerging role of retromer in neuroprotection.
abstract: Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism development and physiology. Retromer is a master controller of integral membrane protein sorting and transport through one of the major sorting station within eukaryotic cells, the endosomal network. Subtle de-regulation of retromer is an emerging theme in the pathoetiology of Parkinson's disease. Here we summarise recent advances in defining the neuroprotective role of retromer and how its de-regulation may contribute to Parkinson's disease by interfering with: lysosomal health and protein degradation, association with accessory proteins including the WASH complex and mitochondrial health.
authors.affiliation: School of Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD, UK.
authors.forename: Kirsty J
authors.initials: KJ
authors.lastname: McMillan
authors.affiliation: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
authors.forename: Hendrick C
authors.initials: HC
authors.lastname: Korswagen
authors.affiliation: School of Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD, UK. Electronic address: pete.cullen@bristol.ac.uk.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Cullen
mesh_terms: D000818:Animals; D021982:Cell-Matrix Junctions / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D000066829:Neuroprotection; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology; D021381:Protein Transport; D059748:Proteolysis
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport