title: Molecular Imaging and Oral Cancer Diagnosis and Therapy.
abstract: Oral cancer is known as one of relatively common type of cancer worldwide. Despite the easy access of the oral cavity to examination, oral tumors are diagnosed in more advanced stages of the disease. Imaging techniques have been recently emerged as non-invasive approaches to detect molecular and cellular changes in living cells and organisms. These techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) could help physicians to screen patients with oral tumors particularly oral squamous cell carcinoma (OSCC) in early stage of the disease. In this review, we discuss that early detection and diagnosis of oral tumors through using more robust and precise imaging techniques and a variety of cellular/molecular biomarkers not only could lead to more effective and less aggressive form of treatment for the disease but also could improve survival rates and lower treatment costs. J. Cell. Biochem. 118: 3055-3060, 2017. © 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Oral and Maxillofacial Radiology, School of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Keshavarzi
authors.affiliation: Department of Oral and Maxillofacial Radiology, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Mansoreh
authors.identifier: 0000-0002-8178-8105
authors.initials: M
authors.lastname: Darijani
authors.affiliation: School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Momeni
authors.affiliation: Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Pouya
authors.initials: P
authors.lastname: Moradi
authors.affiliation: Department of Oral and Maxillofacial Radiology, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Ebrahimnejad
authors.affiliation: Department of Molecular Biotechnology, Royan Institute for Biotechnology, Cell Science Research Center, ACECR, Isfahan, Iran.
authors.forename: Aria
authors.initials: A
authors.lastname: Masoudifar
authors.affiliation: Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Hamed
authors.identifier: 0000-0002-9399-8281
authors.initials: H
authors.lastname: Mirzaei
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy; D006801:Humans; D057054:Molecular Imaging / Q000379:methods*; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor
keywords: DIAGNOSIS; IMAGING TECHNIQUE; ORAL CANCER; THERAPY