title: Insights and Lessons from a Scientific Conference on Non-Invasive Delivery of Macromolecules.
abstract: A growing share of the pharmaceutical development pipeline is occupied by macromolecule drugs, which are primarily administered by injection. Despite decades of attempts, non-invasive delivery of macromolecules has seen only a few success stories. Potential benefits of non-invasive administration include better patient acceptance and adherence and potentially better efficacy and safety. Greater inter-disciplinary dialogue and collaboration are integral to realizing these benefits.
authors.affiliation: Catalent Pharma Solutions, 14 Schoolhouse Road, Somerset, New Jersey, 08873, USA. ronak.savla@catalent.com.
authors.forename: Ronak
authors.identifier: 0000-0002-0907-4714
authors.initials: R
authors.lastname: Savla
authors.affiliation: Department of Pharmacy & Pharmacology, University of Bath, Bath, UK.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Mrsny
authors.affiliation: Departments of Biomedical Engineering and Pharmaceutics, Purdue University, West Lafayette, Indiana, USA.
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Aubert
authors.affiliation: Catalent Pharma Solutions, 14 Schoolhouse Road, Somerset, New Jersey, 08873, USA.
authors.forename: Cornell
authors.initials: C
authors.lastname: Stamoran
mesh_terms: D001812:Blood-Brain Barrier / Q000378:metabolism; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D046911:Macromolecular Substances / Q000008:administration & dosage* / Q000737:chemistry; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D046911:Macromolecular Substances; D004364:Pharmaceutical Preparations
keywords: blood-brain barrier; drug delivery; in vitro models; macromolecules; permeation enhancers