title: Triconoids A-D, Four Limonoids Possess Two Rearranged Carbon Skeletons from Trichilia connaroides.
abstract: Four limonoids, triconoids A-C (1-3) possessing a new rearranged mexicanolide skeleton and triconoid D (4) furnishing a new rearranged 1,2-seco-phragmalin skeleton, were isolated from the Nepalese plant Trichilia connaroides. Two rearranged limonoid skeletons sharing an F ring of methyl 5-oxotetrahydrofuran-2-carboxylate were postulated to be formed biosynthetically via a very unique chemical cascade. Their structures were fully accomplished by spectroscopic data, single-crystal X-ray diffraction, and electrostatic circular dichroism analysis.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
authors.forename: Yao-Yue
authors.initials: YY
authors.lastname: Fan
authors.affiliation: Nepal Academy of Science and Technology, Khumaltar, Lalitpur , GPO Box 3323, Kathmandu, Nepal.
authors.forename: Sajan L
authors.initials: SL
authors.lastname: Shyaula
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
authors.forename: Jian-Min
authors.identifier: 0000-0002-4053-4870
authors.initials: JM
authors.lastname: Yue
mesh_terms: D001669:Biochemical Phenomena; D053898:Biosynthetic Pathways; D036701:Limonins / Q000096:biosynthesis* / Q000737:chemistry; D029582:Meliaceae / Q000378:metabolism*
chemical_list: D036701:Limonins