title: [Spiolto Respimat® : tiotropium-olodaterol fixed combination for therapy of chronic obstructive pulmonary disease (COPD)].
abstract: Chronic Obstructive Pulmonary Disease (COPD) is a chronic airway disease that can be prevented and treated. The recommendations for therapy include bronchodilators from two classes (LAMA (Long Acting Muscarinic Antagonists) and LABA (Long Acting Beta2 Agonists)). Spiolto Respimat® is a LAMA/LABA combination therapy and comprises tiotropium (Spiriva®) and olodaterol (a LABA). Clinical studies show that Spiolto Respimat® is able to improve lung function tests (Increased FEV1, decreased hyperinflation and residual volume) and quality of life as compared to tiotropium or olodaterol. Studies also suggest that COPD exacerbations are decreased in patients treated by Spiolto Respimat® as compared to those treated with olodaterol (results of studies with exacerbations as primary outcome are not available yet). Safety of Spiolto Respimat® appears similar to tiotropium or olodaterol. Spiolto Respimat® indications is maintenance therapy for COPD. Reimbursement in Belgium requires that patients still display symptoms although already treated and that he/she has been previously treated by a LAMA.
authors.affiliation: Département des Sciences Biomédicales et Précliniques et Service de Pneumologie, ULG et CHU de Liège, Site du Sart Tilman, 4000 Liège, Belgique.
authors.forename: D
authors.initials: D
authors.lastname: Cataldo
mesh_terms: D000280:Administration, Inhalation; D001530:Belgium; D048588:Benzoxazines / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D007349:Insurance, Health, Reimbursement; D018727:Muscarinic Antagonists; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D011788:Quality of Life; D000069447:Tiotropium Bromide / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D048588:Benzoxazines; D001993:Bronchodilator Agents; D004338:Drug Combinations; D018727:Muscarinic Antagonists; C000611386:tiotropium-olodaterol; D000069447:Tiotropium Bromide
keywords:  Anticholinergics ;  Beta;  Bronchial obstruction ;  Bronchodilation;  COPD ;  LABA ;  LAMA ; mimetics 