title: Persistent intestinal bleeding due to severe CMV-related thrombocytopenia in a preterm newborn.
abstract: The optimal threshold for neonatal platelet transfusions in sick newborns is still uncertain. We report a congenital cytomegalovirus (CMV) infection in a premature neonate with severe thrombocytopenia who subsequently presented with necrotizing enterocolitis and intestinal bleeding. The baby recovered after platelet transfusions were discontinued and the therapy was switched from intravenous ganciclovir to oral valganciclovir. We discuss both measures, speculating on the key role of platelet transfusions.
authors.affiliation: a Dipartimento Integrato Materno-Infantile , Terapia Intensiva Neonatale, Azienda Ospedaliero-Universitaria Policlinico , Modena , Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Berardi
authors.affiliation: a Dipartimento Integrato Materno-Infantile , Terapia Intensiva Neonatale, Azienda Ospedaliero-Universitaria Policlinico , Modena , Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Spaggiari
authors.affiliation: a Dipartimento Integrato Materno-Infantile , Terapia Intensiva Neonatale, Azienda Ospedaliero-Universitaria Policlinico , Modena , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cattelani
authors.affiliation: a Dipartimento Integrato Materno-Infantile , Terapia Intensiva Neonatale, Azienda Ospedaliero-Universitaria Policlinico , Modena , Italy.
authors.forename: Maria Federica
authors.initials: MF
authors.lastname: Roversi
authors.affiliation: b Struttura Complessa di Microbiologia e Virologia, Azienda Ospedaliero-Universitaria Policlinico , Modena , Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Pecorari
authors.affiliation: c Unità Operativa di Microbiologia , Azienda Ospedaliero-Universitaria Policlinico S. Orsola Malpighi , Bologna , Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Lazzarotto
authors.affiliation: a Dipartimento Integrato Materno-Infantile , Terapia Intensiva Neonatale, Azienda Ospedaliero-Universitaria Policlinico , Modena , Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ferrari
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage; D002585:Cesarean Section; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital* / Q000188:drug therapy; D020345:Enterocolitis, Necrotizing / Q000150:complications / Q000628:therapy; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000628:therapy; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000628:therapy / Q000821:virology*; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000628:therapy / Q000821:virology*; D000077562:Valganciclovir
chemical_list: D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir
keywords: Cytomegalovirus; congenital infection; intestinal bleeding; newborn; thrombocytopenia