title: Alcohol use disorders among people living with HIV/AIDS in Southern Brazil: prevalence, risk factors and biological markers outcomes.
abstract: Alcohol abuse is an important public health problem, frequently unrecognized among people living with HIV/AIDS (PLWHA), and requires investigation and intervention. It is usually associated with lower adherence to highly active antiretroviral therapy (HAART). It can also produce adverse clinical outcomes, such as changes in certain HIV markers, particularly CD4 cell counts and HIV viral loads (VLs). Thus, this study aimed to evaluate the prevalence of alcohol abuse among PLWHA, its associated risk factors and effects on CD4 cell counts and HIV VLs in southern Brazil.
  
  
  
  Between December 2012 and July 2013, 343 patients were interviewed at a reference hospital in southern Brazil. The instrument used was the Alcohol Use Disorder Identification Test (AUDIT), and a cutoff of eight points or more was applied. Socioeconomic, demographic, clinical and laboratory data were also collected. The statistical analysis included a Poisson regression to evaluate the factors associated with alcohol use disorder, and a linear regression was performed to assess the relationship between AUDIT scores and CD4 cell counts and HIV VLs.
  
  
  
  Alcohol abuse was present in 28.6% of the respondents, and possible dependence was present in 5%. The risk factors identified included being male, mixed or black skin color, low education and the use of intravenous or inhaled drugs. A higher AUDIT score was associated with a lower CD4 cell count but was not associated with higher HIV VL values.
  
  
  
  Our results show the importance of screening for alcohol abuse in this group. The prevalence of alcohol abuse was high, and it was associated with socioeconomic factors and the use of illicit drugs. Moreover, AUDIT score negatively affected CD4 cell counts as well.
authors.affiliation: Faculty of Medicine, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil. cmossdasilva@gmail.com.
authors.forename: Cláudio Moss
authors.initials: CM
authors.lastname: da Silva
authors.affiliation: Faculty of Medicine, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil.
authors.forename: Raúl Andrés
authors.initials: RA
authors.lastname: Mendoza-Sassi
authors.affiliation: Faculty of Medicine, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil.
authors.forename: Luisa Dias
authors.initials: LD
authors.lastname: da Mota
authors.affiliation: Faculty of Medicine, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil.
authors.forename: Maíba Mikhael
authors.initials: MM
authors.lastname: Nader
authors.affiliation: Faculty of Medicine, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil.
authors.forename: Ana Maria Barral
authors.initials: AM
authors.lastname: de Martinez
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications* / Q000453:epidemiology; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D015415:Biomarkers; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012959:Socioeconomic Factors; D019562:Viral Load; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Alcohol induced disorders; Brazil; HIV/Aids; Immunologic markers; Prevalence; Risk factors