title: Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers.
abstract: Aggregation of amphiphiles through the action of hydrophobic interactions is a common feature in soft condensed matter systems and is of particular importance in the context of biophysics as it underlies both the generation of functional biological machinery as well as the formation of pathological misassembled states of proteins. Here we explore the aggregation behaviour of amphiphilic polymers using lattice Monte Carlo calculations and show that the distribution of hydrophobic residues within the polymer sequence determines the facility with which dry/wet interfaces can be created and that such interfaces drive the aggregation process.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
authors.forename: Patrick
authors.initials: P
authors.lastname: Varilly
authors.affiliation: Department of Chemistry, MIT, Cambridge, Massachusetts 02139, USA.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Willard
authors.affiliation: Department Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, United Kingdom.
authors.forename: Julius B
authors.initials: JB
authors.lastname: Kirkegaard
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
authors.forename: Tuomas P J
authors.initials: TP
authors.lastname: Knowles
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: David
authors.initials: D
authors.lastname: Chandler