title: Current detection technologies for circulating tumor cells.
abstract: Circulating tumor cells (CTCs) are cancer cells that circulate in the blood stream after being naturally shed from original or metastatic tumors, and can lead to a new fatal metastasis. CTCs have become a hotspot research field during the last decade. Detection of CTCs, as a liquid biopsy of tumors, can be used for early diagnosis of cancers, earlier evaluation of cancer recurrence and chemotherapeutic efficacy, and choice of individual sensitive anti-cancer drugs. Therefore, CTC detection is a crucial tool to fight against cancer. Herein, we classify the currently reported CTC detection technologies, introduce some representative samples for each technology, conclude the advantages and limitations, and give a future perspective including the challenges and opportunities of CTC detection.
authors.affiliation: CAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 ZhongGuan West Road, Ningbo, Zhejiang 315201, China. aiguo@nimte.ac.cn.
authors.forename: Zheyu
authors.initials: Z
authors.lastname: Shen
authors.forename: Aiguo
authors.initials: A
authors.lastname: Wu
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D001775:Blood Circulation; D006801:Humans; D017705:Lignans; D057230:Limit of Detection; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D009360:Neoplastic Cells, Circulating; D061848:Optical Imaging / Q000379:methods; D010316:Particle Size; D013057:Spectrum Analysis / Q000379:methods; D013499:Surface Properties
chemical_list: D017705:Lignans