title: A selective and light-up fluorescent probe for β-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative.
abstract: An aggregation induced emission (AIE) based bioimaging probe, TPE-Gal, was designed for light-up imaging of β-galactosidase in living cells. The applicability of TPE-Gal in imaging endogenous β-galactosidase activity was confirmed in OVCAR-3 cells.
authors.affiliation: Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, P. R. China. wangjg@iccas.ac.cn.
authors.forename: Guoyu
authors.initials: G
authors.lastname: Jiang
authors.forename: Guanjie
authors.initials: G
authors.lastname: Zeng
authors.forename: Wenping
authors.initials: W
authors.lastname: Zhu
authors.forename: Yongdong
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaobiao
authors.initials: X
authors.lastname: Dong
authors.forename: Guanxin
authors.initials: G
authors.lastname: Zhang
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Fan
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wang
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Wu
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D005260:Female; D005456:Fluorescent Dyes / Q000032:analysis / Q000737:chemistry*; D005690:Galactose / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008027:Light; D015394:Molecular Structure; D061848:Optical Imaging; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013267:Stilbenes / Q000737:chemistry*; D013329:Structure-Activity Relationship; D001616:beta-Galactosidase / Q000032:analysis* / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D013267:Stilbenes; C000617116:tetraphenylethylene; D001616:beta-Galactosidase; D005690:Galactose