title: Tissue Engineering Therapy for Atrophic Maxilla Using Minimally Manipulated CD90 and CD105 Bone Marrow Stem Cells: A Case Report.
abstract: Bone deficiencies in the jaws of edentulous patients limit the possibility of successful placement and osseointegration of endosseous implants. Bone resorption is defined as a vertical and horizontal loss of quality and quantity in the residual bone ridges; lack of bone structure requires bone grafting procedures to enable implant placement and to improve the function, predictability, and longevity of implants. The objective of this case study was to demonstrate the feasibility of a novel cell therapy treatment for localized jaw bone defects with tissue repair cells composed of a mixture of bone marrow-derived cells, including CD90+ mesenchymal stem cells and CD105+ monocytes/macrophages, and xenograft blocks, in what would be a safe and efficacious approach to the regeneration of localized craniofacial bone defects. The use of stem cells represents an alternative that could offer improved results, better quality histologically, and greater quantity in millimeters of tissue in bone regeneration.
authors.forename: Erick
authors.initials: E
authors.lastname: Valdivia
authors.forename: Gerardo
authors.initials: G
authors.lastname: Mendoza-Azpur
authors.forename: Jhon
authors.initials: J
authors.lastname: Pando
authors.forename: Heydi
authors.initials: H
authors.lastname: Cornejo
authors.forename: Antonio
authors.initials: A
authors.lastname: Carrasco
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: David
authors.initials: D
authors.lastname: Kim
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001284:Atrophy; D016026:Bone Marrow Transplantation; D001861:Bone Regeneration / Q000502:physiology; D054893:Cone-Beam Computed Tomography; D003758:Dental Implantation, Endosseous / Q000379:methods*; D000071063:Endoglin; D005240:Feasibility Studies; D064593:Heterografts; D006801:Humans; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009066:Mouth, Edentulous / Q000000981:diagnostic imaging / Q000601:surgery; D018800:Thy-1 Antigens; D023822:Tissue Engineering
chemical_list: C064206:ENG protein, human; D000071063:Endoglin; D018800:Thy-1 Antigens