title: Selective entrainment of gamma subbands by different slow network oscillations.
abstract: Theta oscillations (4-12 Hz) are thought to provide a common temporal reference for the exchange of information among distant brain networks. On the other hand, faster gamma-frequency oscillations (30-160 Hz) nested within theta cycles are believed to underlie local information processing. Whether oscillatory coupling between global and local oscillations, as showcased by theta-gamma coupling, is a general coding mechanism remains unknown. Here, we investigated two different patterns of oscillatory network activity, theta and respiration-induced network rhythms, in four brain regions of freely moving mice: olfactory bulb (OB), prelimbic cortex (PLC), parietal cortex (PAC), and dorsal hippocampus [cornu ammonis 1 (CA1)]. We report differential state- and region-specific coupling between the slow large-scale rhythms and superimposed fast oscillations. During awake immobility, all four regions displayed a respiration-entrained rhythm (RR) with decreasing power from OB to CA1, which coupled exclusively to the 80- to 120-Hz gamma subband (γ2). During exploration, when theta activity was prevailing, OB and PLC still showed exclusive coupling of RR with γ2and no theta-gamma coupling, whereas PAC and CA1 switched to selective coupling of theta with 40- to 80-Hz (γ1) and 120- to 160-Hz (γ3) gamma subbands. Our data illustrate a strong, specific interaction between neuronal activity patterns and respiration. Moreover, our results suggest that the coupling between slow and fast oscillations is a general brain mechanism not limited to the theta rhythm.
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.|Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.|Department of Neurology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
authors.forename: Mareva
authors.initials: M
authors.lastname: Ciatipis
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.|Department of Molecular Sensory Systems, Research Center Caesar, 53175 Bonn, Germany.
authors.forename: Thérèse
authors.initials: T
authors.lastname: Wolfenstetter
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Jakob
authors.initials: J
authors.lastname: Jessberger
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Carola
authors.initials: C
authors.lastname: Müller
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Ponsel
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Yevgenij
authors.initials: Y
authors.lastname: Yanovsky
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany; jurij.brankack@physiologie.uni-heidelberg.de.
authors.forename: Jurij
authors.initials: J
authors.lastname: Brankačk
authors.affiliation: Brain Institute, Federal University of Rio Grande do Norte, RN 59056-450 Natal, Brazil.
authors.forename: Adriano B L
authors.identifier: 0000-0002-9877-7816
authors.initials: ABL
authors.lastname: Tort
authors.affiliation: Institute for Physiology and Pathophysiology, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Draguhn
keywords: cross-frequency coupling; gamma subbands; neocortex; respiration; theta