title: Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Review of the Phenotype and Associated Specific Features.
abstract: Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic disease that is associated with inflammatory bowel disease (IBD) in approximately 70% of cases. Although the pathogenesis is still unknown for both diseases, there is increasing evidence to indicate that they share a common underlying predisposition. Herein, we review the epidemiology, diagnosis, disease pathogenesis, and specific clinical features of the PSC-IBD phenotype. Patients with PSC-IBD have a distinct IBD phenotype with an increased incidence of pancolitis, backwash ileitis, and rectal sparing. Despite often having extensive colonic involvement, these patients present with mild intestinal symptoms or are even asymptomatic, which can delay the diagnosis of IBD. Although the IBD phenotype has been well characterized in PSC patients, the natural history and disease behavior of PSC in PSC-IBD patients is less well defined. There is conflicting evidence regarding the course of IBD in PSC-IBD patients who receive liver transplantation and their risk of recurrent PSC. IBD may also be associated with an increased risk of cholangiocarcinoma in PSC patients. Overall, the PSC-IBD population has an increased risk of developing colorectal neoplasia compared to the conventional IBD population. Lifelong annual surveillance colonoscopy is currently recommended.
authors.affiliation: Division of Gastroenterology, Surgical Department, Hospital Beatriz Ângelo, Loures, Portugal.
authors.forename: Carolina
authors.initials: C
authors.lastname: Palmela
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
authors.forename: Farhad
authors.initials: F
authors.lastname: Peerani
authors.affiliation: Division of Internal Medicine, Mount Sinai St. Luke's and Mount Sinai West Hospitals, New York, NY, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Castaneda
authors.affiliation: Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Joana
authors.initials: J
authors.lastname: Torres
authors.affiliation: Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Itzkowitz
mesh_terms: D015209:Cholangitis, Sclerosing / Q000150:complications* / Q000473:pathology; D003106:Colon / Q000473:pathology; D015179:Colorectal Neoplasms / Q000209:etiology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D010641:Phenotype; D012307:Risk Factors
keywords: Cholangitis, sclerosing; Colorectal neoplasms; Diagnosis; Inflammatory bowel disease; Liver transplantation