title: Chinese Data of Efficacy of Low- and High-Dose Iodine-131 for the Ablation of Thyroid Remnant.
abstract: Chinese data on the efficacy of low- and high-dose radioiodine for thyroid remnant are still absent. The aim of the study was to investigate whether a low dose of radioiodine is as effective as a high dose for remnant ablation in Chinese patients.
  
  
  
  Patients presenting for radioiodine ablation in the authors' department were included. Inclusion criteria were aged ≥16 years, total or near-total thyroidectomy, tumor-node-metastasis (TNM) stage of pT1-3, any N stage, and M0. All patients were randomly allocated to either the high-dose group of 3700 MBq or the low-dose group of 1850 MBq for remnant ablation. The response to treatment was defined as successful or unsuccessful after a six- to nine-month interval. Ablation was considered to be successful if patients fulfilled the following criteria: no tracer uptake in the thyroid bed on diagnosis whole-body scanning and a negative level of serum thyroglobulin.
  
  
  
  There were 327 patients enrolled between January 2013 and December 2014. More than 95% had papillary thyroid cancer. Data could be analyzed for 278 cases (Mage= 44 years; 71.6% women), 155 in the low-dose group and 123 in the high-dose group. The rate of initial successful ablation was 84.2% in all patients, 82.6% in the low-dose group, and 86.2% in the high-dose group. There was no difference between the two groups (p = 0.509).
  
  
  
  In Chinese patients with differentiated thyroid carcinoma, the low dose of 1850 MBq radioiodine activity is as effective as a high dose of 3700 MBq for thyroid remnant ablation.
authors.affiliation: Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .
authors.forename: Fang
authors.initials: F
authors.lastname: Feng
authors.affiliation: Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .
authors.forename: Hongliang
authors.initials: H
authors.lastname: Fu
authors.affiliation: Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .
authors.forename: Shuqi
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .
authors.forename: Suyun
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Nuclear Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China .
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002291:Carcinoma, Papillary / Q000208:ethnology / Q000532:radiotherapy / Q000601:surgery*; D002681:China; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000628:therapy*; D011446:Prospective Studies; D013954:Thyroglobulin / Q000097:blood; D000077273:Thyroid Cancer, Papillary; D013961:Thyroid Gland / Q000528:radiation effects / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000208:ethnology / Q000532:radiotherapy / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes; C000614965:Iodine-131; D013954:Thyroglobulin
keywords: China; prospective study; radioiodine; remnant ablation; thyroid carcinoma