title: Association of the genetic markers for myocardial infarction with sudden cardiac death.
abstract: OBJECTIVE
  Investigate the association of rs17465637 gene MIAF3 (1q41), rs1376251 gene TAS2R50 (12p13), rs4804611 gene ZNF627 (19p13), rs619203 gene ROS1 (6q22), rs1333049 (9p21), rs10757278 (9p21), rs2549513 (16q23), rs499818 (6p24) associated with myocardial infarction available from the international genome-wide studies with sudden cardiac death (SCD) in a case-control study.
  
  
  METHODS
  A sample of SCD cases (n=285) was formed using the WHO criteria; the control sample (n=421) was selected according to sex and age. DNA was isolated by phenol-chloroform extraction from the myocardial tissue of SCD cases and blood of control cases. The groups were genotyped for the selected SNPs by real-time PCR using TaqMan probes (Applied Biosystems, United States).
  
  
  RESULTS
  No statistically significant differences in the genotype and allelic frequencies of studied single nucleotide polymorphisms between sudden cardiac death cases and control were detectable in general group. By separating the groups of sex and age differences in the genotype frequencies of rs1333049, rs10757278 and rs499818 are statistical significance. Genotypes CC of rs1333049 and GG of rs10757278 are associated with an increased sudden cardiac death risk in men (p=0.019, OR=1.7, 95% CI 1.1-2.8; p=0.011, OR=1.8, 95% CI 1.2-2.8, respectively). Genotype AG of rs499818 is associated with an increased sudden cardiac death risk in the women over 50 years old (p=0.009, OR=2.4, 95% CI 1.3-4.6).
  
  
  CONCLUSIONS
  Polymorphisms rs1333049 and rs10757278 are associated with SCD in men and rs499818 in the women aged over 50 years.
authors.affiliation: Federal State Budgetary of Scientific Institution "Institution of Internal and Preventive Medicine", Novosibirsk, Russia. Electronic address: ivanova_a_a@mail.ru.
authors.forename: Anastasiya A
authors.initials: AA
authors.lastname: Ivanova
authors.affiliation: Federal State Budgetary of Scientific Institution "Institution of Internal and Preventive Medicine", Novosibirsk, Russia. Electronic address: medik11@mail.ru.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Maksimov
authors.affiliation: Federal State Budgetary of Scientific Institution "Institution of Internal and Preventive Medicine", Novosibirsk, Russia. Electronic address: orlovpavel86@gmail.com.
authors.forename: Pavel S
authors.initials: PS
authors.lastname: Orlov
authors.affiliation: Federal State Budgetary of Scientific Institution "Institution of Internal and Preventive Medicine", Novosibirsk, Russia. Electronic address: dinara2084@mail.ru.
authors.forename: Dinara E
authors.initials: DE
authors.lastname: Ivanoshchuk
authors.affiliation: Novosibirsk Regional Office of Forensic Medical Examination, Novosibirsk, Russia.
authors.forename: Sergei V
authors.initials: SV
authors.lastname: Savchenko
authors.affiliation: Federal State Budgetary of Scientific Institution "Institution of Internal and Preventive Medicine", Novosibirsk, Russia. Electronic address: mvoevoda@ya.ru.
authors.forename: Mikhail I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D004247:DNA / Q000235:genetics*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D015996:Survival Rate / Q000639:trends
chemical_list: D005819:Genetic Markers; D011518:Proto-Oncogene Proteins; D004247:DNA; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human
keywords: 9p21; Sudden cardiac death; rs1376251; rs17465637; rs2549513; rs4804611; rs499818; rs619203