title: SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN MACULA-INVOLVING CYTOMEGALOVIRUS RETINITIS.
abstract: OBJECTIVE
  To evaluate the microstructural features of cytomegalovirus (CMV) retinitis by spectral domain optical coherence tomography (OCT).
  
  
  METHODS
  Subjects were patients with macula-involving CMV retinitis with OCT imaging. The leading edge of retinitis in the macula was identified based on fundus imaging, and OCT findings were longitudinally evaluated in three areas: within the area of active retinitis, at the leading edge of retinitis, and just beyond the leading edge of retinitis.
  
  
  RESULTS
  Optical coherence tomography imaging of macular CMV retinitis identified vitreous cells in 10 eyes (100%), posterior vitreous detachment in four eyes (40%), broad-based vitreomacular traction in one eye (10%), epiretinal membrane in eight eyes (80%), and lamellar hole-associated epiretinal proliferation associated with an atrophic hole in one eye (10%). Retinal architectural disruption, disruption of inner retinal layers, disruption of the external limiting membrane, and ellipsoid zone abnormalities were noted within the area of retinitis in all eyes and decreased in frequency and severity at and beyond the leading edge of retinitis, although all 10 eyes (100%) exhibited one of these abnormalities, especially outer retinal microabnormalities, beyond the leading edge of retinitis.
  
  
  CONCLUSIONS
  Microstructural abnormalities were frequently noted on OCT of CMV retinitis, including within the retina beyond the leading edge of retinitis identified by corresponding fundus imaging. Outer retinal abnormalities were noted more frequently than inner retinal abnormalities beyond the leading edge of retinitis. These findings provide insight into the effects of CMV retinitis on retinal microstructure and potentially on vision and highlight the potential utility of OCT for monitoring microprogression of macula-involving CMV retinitis.
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
authors.forename: Mrinali P
authors.initials: MP
authors.lastname: Gupta
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
authors.forename: Sarju
authors.initials: S
authors.lastname: Patel
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
authors.forename: Anton
authors.initials: A
authors.lastname: Orlin
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Marlow
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
authors.forename: Ru-Ik
authors.initials: RI
authors.lastname: Chee
authors.affiliation: Albert Einstein College of Medicine, New York, New York.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Nadelmann
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.|Department of Ophthalmology, Illinois Eye & Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois.
authors.forename: R V Paul
authors.initials: RVP
authors.lastname: Chan
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
authors.forename: Donald J
authors.initials: DJ
authors.lastname: DʼAmico
authors.affiliation: Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
authors.forename: Szilard
authors.initials: S
authors.lastname: Kiss
mesh_terms: D000328:Adult; D017726:Cytomegalovirus Retinitis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D019773:Epiretinal Membrane / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity; D014822:Vitreous Body / Q000473:pathology; D055815:Young Adult