title: The relationship of serum alanine aminotransferase normal-range levels to arterial stiffness and metabolic syndrome in non-drinkers and drinkers: a Chinese community-based analysis.
abstract: BACKGROUND
  Few studies have investigated the relationship between carotid-femoral pulse wave velocity (cfPWV) and serum alanine aminotransferase (ALT) normal-range levels across the world. The current analysis was designed to explore the relationship of serum ALT normal-range levels to cfPWV and metabolic syndrome (Mets) in non-drinkers and drinkers in a Chinese community-dwelling population.
  
  
  METHODS
  There were 2202 participants with serum ALT levels within normal range enrolled for the current analysis.
  
  
  RESULTS
  Median (range) age of participants was 53 (18-96) years, 51.5% were males, and 31.2% were drinkers. Prevalence of Mets was 29.4%. Median (range) of cfPWV was 10.1 (2.4-32.7) m/s. Hazard ratios for prevalence of Mets, central obesity and high triglyceride significantly increased with elevated levels of serum ALT in both non-drinkers and drinkers (p < 0.05 for all). Hazard ratios for prevalence of cfPWV > 10 m/s, high blood pressure and high blood glucose significantly increased with elevated levels of serum ALT in non-drinkers (p < 0.05 for all), but not in drinkers (p ≥ 0.05 for all).
  
  
  CONCLUSIONS
  In a Chinese community-dwelling population, prevalence of Mets and its components (including central obesity and high TG) increased with an elevation in serum ALT levels within normal range in both non-drinkers and drinkers, while cfPWV and other components of Mets, such as high blood pressure and glucose, increased with an elevation in serum ALT levels in non-drinkers, but not in drinkers.
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China.|Department of Cardiology and Hainan Branch, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Shihui
authors.initials: S
authors.lastname: Fu
authors.affiliation: Department of Cardiology and Hainan Branch, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China. lleim@sina.com.
authors.forename: Leiming
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China. sci301@126.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood*; D064829:Alcohol Abstinence / Q000706:statistics & numerical data*; D000428:Alcohol Drinking / Q000097:blood / Q000453:epidemiology*; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D057187:Independent Living; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000453:epidemiology; D015995:Prevalence; D016016:Proportional Hazards Models; D063177:Pulse Wave Analysis; D014280:Triglycerides / Q000097:blood; D014652:Vascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D000410:Alanine Transaminase
keywords: Alanine aminotransferase; Alcohol intake; Arterial stiffness; Chinese community-based analysis; Metabolic syndrome