title: Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis.
abstract: Background. Previous studies have revealed that gene polymorphisms of inflammatory factors may influence the development or progression of periodontitis, a main cause of tooth loss in adults; however, due to limitations of individual studies, inconsistent findings were reported.Objective. To meta-analytically investigate the relationship between periodontitis and the Interleukin-4 (IL-4) and Interleukin-4 receptor (IL-4R) gene polymorphisms.Methods. Databases were searched for relevant case-control studies. After study selection based on the predefined selection criteria, methodological quality assessment and data extraction were conducted independently by two reviewers, before subsequent statistical analyses.Results. 37 studies involving 4,385 patients and 5,168 controls were included. All the studied IL-4 polymorphisms were not significantly associated with periodontitis, except the -33C/T (CT versus CC: OR = 0.50, 95% CI = 0.28-0.88) associated with reduced AgP susceptibility. Positive association was found between IL-4R Q551 polymorphism and periodontitis susceptibility in three genetic models (R versus Q: OR = 1.59, 95% CI = 1.14-2.22; QR versus QQ: OR = 1.84, 95% CI = 1.21-2.80; RR + QR versus QQ: OR = 1.82, 95% CI = 1.22-2.72).Conclusions. A positive association exists between the IL-4R Q551R polymorphism and occurrence of CP. The IL-4 -33 CT genotype is negatively associated with the occurrence of AgP.
authors.affiliation: Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
authors.forename: Xiao-Wei
authors.identifier: 0000-0003-1975-5932
authors.initials: XW
authors.lastname: Jia
authors.affiliation: Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
authors.forename: Ya-Di
authors.identifier: 0000-0002-7030-5710
authors.initials: YD
authors.lastname: Yuan
authors.affiliation: Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
authors.forename: Zhong-Xiong
authors.identifier: 0000-0001-6726-4949
authors.initials: ZX
authors.lastname: Yao
authors.affiliation: Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
authors.forename: Chang-Jing
authors.identifier: 0000-0002-2616-9766
authors.initials: CJ
authors.lastname: Wu
authors.affiliation: Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
authors.forename: Xiang
authors.identifier: 0000-0002-8647-9715
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
authors.forename: Xue-Hong
authors.initials: XH
authors.lastname: Chen
authors.affiliation: Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
authors.forename: Ying-Mei
authors.identifier: 0000-0003-4897-6080
authors.initials: YM
authors.lastname: Lin
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Xiang-Yu
authors.identifier: 0000-0001-5669-3502
authors.initials: XY
authors.lastname: Meng
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Xian-Tao
authors.identifier: 0000-0003-1262-725X
authors.initials: XT
authors.lastname: Zeng
authors.affiliation: Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou 510800, China.
authors.forename: Jun
authors.identifier: 0000-0003-3478-5881
authors.initials: J
authors.lastname: Shao
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics* / Q000276:immunology; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics* / Q000276:immunology; D008957:Models, Genetic; D011110:Polymorphism, Genetic
chemical_list: C508598:IL4 protein, human; C504000:IL4R protein, human; D053662:Interleukin-4 Receptor alpha Subunit; D015847:Interleukin-4