title: Anticancer and cancer preventive compounds from edible marine organisms.
abstract: A direct impact of food on health, which demonstrates that dietary habit is one of the most important determinants of chronic diseases such as cancers, has led to an increased interest of the consumers toward natural bioactive compounds as functional ingredients or nutraceuticals. Epidemiological studies revealed that the populations of many Asian countries with high consumption of fish and seafood have low prevalence of particular type of cancers such as lung, breast, colorectal and prostate cancers. This observation has led to extensive investigations of the benefits of compounds present in edible marine organisms such as fish, marine invertebrates (mollusks, echinoderms) and marine algae as cancer chemopreventive agents. Interestingly, many of these marine organisms not only constitute as seafood delicacy but also as ingredients used in folk medicine of some East and Southeast Asian countries. The results of the investigations on extracts and compounds from fish (cods, anchovy, eel and also fish protein hydrolysates), mollusks (mussel, oyster, clams and abalone), as well as from sea cucumbers on the in vivo/in vitro anticancer/antitumor activities can, in part, support the health benefits of these edible marine organisms.
authors.affiliation: Laboratório de Química Orgânica, Departamento de Ciências Químicas e Farmacêuticas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n- 4450-208, Matosinhos, Portugal.
authors.forename: Marta
authors.initials: M
authors.lastname: Correia-da-Silva
authors.affiliation: Laboratório de Química Orgânica, Departamento de Ciências Químicas e Farmacêuticas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n- 4450-208, Matosinhos, Portugal.
authors.forename: Emília
authors.initials: E
authors.lastname: Sousa
authors.affiliation: Laboratório de Química Orgânica, Departamento de Ciências Químicas e Farmacêuticas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n- 4450-208, Matosinhos, Portugal.
authors.forename: Madalena M M
authors.initials: MMM
authors.lastname: Pinto
authors.affiliation: Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n- 4450-208, Matosinhos, Portugal. Electronic address: ankijjoa@icbas.up.pt.
authors.forename: Anake
authors.initials: A
authors.lastname: Kijjoa
mesh_terms: D000818:Animals; D059001:Aquatic Organisms; D006801:Humans; D009369:Neoplasms / Q000178:diet therapy* / Q000473:pathology / Q000517:prevention & control; D017747:Seafood
keywords: Antitumor; Cancer chemoprevention; Fish and fish protein hydrolysates; Mollusk; Sea cucumber; Seafood