title: A Single Center Analysis of the Positivity of Hepatitis B Antibody after Neonatal Vaccination Program in Korea.
abstract: The antibody to hepatitis B surface antigen (anti-HBs) seropositivity rate after 3 doses of hepatitis B virus (HBV) vaccination during infancy period is known to be higher than 90%. However, a considerable number of vaccines do not form protective anti-HBs or chronologic decrease of anti-HBs. We retrospectively collected data of HBV serologic test results in 20,738 individuals from 2000 to 2015. After exclusion criteria were applied, 19,072 individuals were included. We analyzed the anti-HBs seropositivity rate, anti-HBs disappearance rate, anti-HBs positive seroconversion rate after receiving a booster vaccine, and the difference in anti-HBs positivity between the 2 groups; group A (born before 2005, while both recombinant vaccines and plasma-derived vaccines were used) and group B (born after 2005, when only recombinant vaccines were used by national regulation). The anti-HBs seropositivity rate was 55.8%, but there was a significant difference in the rate of seropositivity for anti-HBs between the group A and B (53.0% vs. 78.1%, P < 0.001). There was no significant age-adjusted difference in the mean seropositivity rate between the 2 groups (P = 0.058). In addition, the anti-HBs positivity rate was significantly lower in the group A as compared with the group B during infancy (83.1% vs. 92.1%, P < 0.001). A total of 1,106 anti-HBs-positive subjects underwent serologic tests more than twice. Of these, 217 subjects (19.6%) showed anti-HBs disappearance. After booster vaccinations, 87.4% (83/95) achieved seroconversion from seronegative to seropositive. Our results highlight the importance of lifelong protection against HBV and the possible necessity of booster vaccination after adolescent period.
authors.affiliation: Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. kyjoo@hanyang.ac.kr.
authors.forename: Yong Joo
authors.identifier: http://orcid.org/0000-0002-2654-5397
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Database and Bioinformatics Laboratory, College of Electrical and Computer Engineering, Chungbuk National University, Cheongju, Korea.
authors.forename: Peipei
authors.identifier: http://orcid.org/0000-0001-5761-9814
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, College of Medicine, Chungbuk National University, Cheongju, Korea.
authors.forename: Jong Myeon
authors.identifier: http://orcid.org/0000-0002-1659-8516
authors.initials: JM
authors.lastname: Hong
authors.affiliation: Database and Bioinformatics Laboratory, College of Electrical and Computer Engineering, Chungbuk National University, Cheongju, Korea.
authors.forename: Keun Ho
authors.identifier: http://orcid.org/0000-0003-0394-9054
authors.initials: KH
authors.lastname: Ryu
authors.affiliation: Biostatistics Consulting and Research Lab, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Eunwoo
authors.identifier: http://orcid.org/0000-0001-5175-7095
authors.initials: E
authors.lastname: Nam
authors.affiliation: Biostatistics Consulting and Research Lab, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Mi Soo
authors.identifier: http://orcid.org/0000-0002-9535-7226
authors.initials: MS
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D017589:Immunization Programs; D007117:Immunization, Secondary; D008297:Male; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000276:immunology; D056910:Republic of Korea; D012189:Retrospective Studies; D014611:Vaccination; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D011994:Recombinant Proteins
keywords: Booster; Children; Hepatitis B antibody; Plasma-derived Vaccine; Recombinant DNA Vaccine; South Korea