title: Naftopidil Improves Symptoms in a Rat Model of Tranilast-Induced Interstitial Cystitis.
abstract: OBJECTIVE
  The effect of naftopidil on symptoms of tranilast-induced interstitial cystitis (IC) was examined in rats.
  
  
  METHODS
  Thirty-two female rats were divided into four groups (control, naftopidil, tranilast, and combination groups). Rats in the control group were fed a standard diet, while rats in the naftopidil, tranilast, and combination groups were fed diets containing naftopidil, tranilast, or naftopidil + tranilast, respectively. After 4 weeks of treatment, locomotor activity was measured and continuous cystometry was performed.
  
  
  RESULTS
  During the light period, locomotor activity was lower in the tranilast group than in the control, naftopidil, and combination groups. During the dark period, locomotor activity was higher in the naftopidil group than in the other three groups. The combination group showed higher locomotor activity than the tranilast group, but significantly lower activity than the naftopidil group. Continuous cystometry revealed that the interval between bladder contractions was shorter in the tranilast group than in the other three groups. The combination group also had a shorter interval between contractions than the control group.
  
  
  CONCLUSIONS
  Naftopidil improved the symptoms of tranilast-induced IC, such as reduced locomotor activity due to pelvic pain and a shortened interval between bladder contractions. Therefore, naftopidil may be a potential treatment for IC.
authors.affiliation: Southern Knights' Laboratory LLP, Okinawa, Japan.
authors.forename: Kimio
authors.initials: K
authors.lastname: Sugaya
authors.affiliation: Southern Knights' Laboratory LLP, Okinawa, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Nishijima
authors.affiliation: Southern Knights' Laboratory LLP, Okinawa, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kadekawa
authors.affiliation: Southern Knights' Laboratory LLP, Okinawa, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Ashitomi
authors.affiliation: Faculty of Medicine, The Institute for Animal Experiments, University of the Ryukyus, Okinawa, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ueda
authors.affiliation: Department of Biochemistry, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D018926:Anti-Allergic Agents / Q000009:adverse effects*; D018856:Cystitis, Interstitial / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D062367:ortho-Aminobenzoates / Q000009:adverse effects*
chemical_list: D000317:Adrenergic alpha-Antagonists; D018926:Anti-Allergic Agents; D004338:Drug Combinations; D009281:Naphthalenes; D010879:Piperazines; D062367:ortho-Aminobenzoates; C012293:tranilast; C064357:naftopidil
keywords: interstitial cystitis; naftopidil; tranilast