title: Diversity-Oriented Synthesis of Spiroannulated Benzofuran-3-one Scaffold of Leptosphaerin C and Congeners via Aryne Insertion.
abstract: A concise synthesis of functionalized cyclohexenone-fused spirobenzofuran-3-ones under mild reaction conditions was developed. The reaction proceeds via insertion of aryne into the C-O bond followed by a regioselective intramolecular conjugate addition. The use of silyl-protected acid was crucial for the transformation. This protocol was successfully applied for the synthesis of leptosphaerin C core and its novel analogues.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Ranjeet A
authors.initials: RA
authors.lastname: Dhokale
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Santosh B
authors.identifier: 0000-0002-5859-0838
authors.initials: SB
authors.lastname: Mhaske