title: Diversity and functions of intestinal mononuclear phagocytes.
abstract: The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mφ) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these subsets play several non-redundant roles in the regulation of intestinal immune responses. While much remains to be learnt, recent findings also underline how the various populations of MNP adapt to deal with the challenges specific to their environment. Understanding these processes should help target individual subsets for 'fine tuning' immunological responses within the intestine, a process that may be of relevance both for the treatment of inflammatory bowel disease (IBD) and for optimized vaccine design.
authors.affiliation: Section of Immunology and Vaccinology, Danish Technical University Veterinary Institute, Copenhagen, Denmark.|Section of Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Joeris
authors.affiliation: Section of Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Müller-Luda
authors.affiliation: Section of Immunology and Vaccinology, Danish Technical University Veterinary Institute, Copenhagen, Denmark.|Section of Immunology, Department of Experimental Medical Science, Lund University, Lund, Sweden.
authors.forename: W W
authors.initials: WW
authors.lastname: Agace
authors.affiliation: Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, Scotland, UK.
authors.forename: A McI
authors.initials: AM
authors.lastname: Mowat
mesh_terms: D000818:Animals; D006801:Humans; D018928:Immunity, Mucosal; D056747:Immunomodulation; D007167:Immunotherapy / Q000379:methods*; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000628:therapy; D007413:Intestinal Mucosa / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology*; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines