title: Novel mechanism of PCNA control through acetylation of its sliding surface.
abstract: Recent findings revealed a new unexpected regulatory mechanism that controls the proliferating cell nuclear antigen (PCNA). Multiple positively-charged lysine residues located on the ring inner surface are neutralized by acetylation and required for cellular resistance to Desoxyribonucleic acid (DNA) damage. Here, we summarize the key observations, discuss implications, and perspectives linked to cancer, as well as challenges for future work.
authors.affiliation: Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center , New York, NY, USA.
authors.forename: Pierre
authors.initials: P
authors.lastname: Billon
authors.affiliation: St-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Centre de Recherche du CHU de Québec-Axe Oncologie , Quebec City, QC, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Côté
keywords: Cancer mutations; DNA damage; DNA polymerases; DNA replication; PCNA; lysine acetylation; sliding surface