title: A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia.
abstract: During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.
authors.affiliation: Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy; INBB, National Institute for Biostructures and Biosystems, 00136 Rome, Italy; National Cancer Research Center, IRCCS Istituto Oncologico "Giovanni Paolo II," 70124 Bari, Italy.
authors.forename: Oihane
authors.initials: O
authors.lastname: Garcia-Irigoyen
authors.affiliation: Department of Interdisciplinary Medicine, "Aldo Moro" University of Bari, 70124 Bari, Italy; INBB, National Institute for Biostructures and Biosystems, 00136 Rome, Italy; National Cancer Research Center, IRCCS Istituto Oncologico "Giovanni Paolo II," 70124 Bari, Italy. Electronic address: antonio.moschetta@uniba.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Moschetta
mesh_terms: D001647:Bile Acids and Salts; D002779:Cholestasis; D019446:Endotoxemia; D006801:Humans; D058847:Inflammasomes; D018160:Receptors, Cytoplasmic and Nuclear
chemical_list: D001647:Bile Acids and Salts; D058847:Inflammasomes; D018160:Receptors, Cytoplasmic and Nuclear
keywords: FXR; bile acids; cholestasis; inflammasome; nuclear receptors; sepsis