title: [Tissue engineering of urinary bladder using acellular matrix].
abstract: BACKGROUND
  Tissue engineering has become a new promising strategy for repairing damaged organs of the urinary system, including the bladder. The basic idea of tissue engineering is to integrate cellular technology and advanced bio-compatible materials to replace or repair tissues and organs.
  
  
  OBJECTIVE
  of the study is the objective reflection of the current trends and advances in tissue engineering of the bladder using acellular matrix through a systematic search of preclinical and clinical studies of interest.
  
  
  METHODS
  Relevant studies, including those on methods of tissue engineering of urinary bladder, was retrieved from multiple databases, including Scopus, Web of Science, PubMed, Embase. The reference lists of the retrieved review articles were analyzed for the presence of the missing relevant publications. In addition, a manual search for registered clinical trials was conducted in clinicaltrials.gov.
  
  
  CONCLUSIONS
  Following the above search strategy, a total of 77 eligible studies were selected for further analysis. Studies differed in the types of animal models, supporting structures, cells and growth factors. Among those, studies using cell-free matrix were selected for a more detailed analysis.
  
  
  CONCLUSIONS
  Partial restoration of urothelium layer was observed in most studies where acellular grafts were used for cystoplasty, but no the growth of the muscle layer was observed. This is the main reason why cellular structures are more commonly used in clinical practice.
authors.affiliation: Sechenov First Moscow State Medical University, Research Institute for Uronephrology and Human Reproductive Health, Moscow, Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Glybochko
authors.affiliation: Scientific Center on Expertise of Medical Application Products of Minzdrav of Russia, Moscow, Russia.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Olefir
authors.affiliation: Sechenov First Moscow State Medical University, Research Institute for Uronephrology and Human Reproductive Health, Moscow, Russia.
authors.forename: Yu G
authors.initials: YG
authors.lastname: Alyaev
authors.affiliation: Sechenov First Moscow State Medical University, Research Institute for Uronephrology and Human Reproductive Health, Moscow, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Butnaru
authors.affiliation: Sechenov First Moscow State Medical University, Research Institute for Uronephrology and Human Reproductive Health, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Bezrukov
authors.affiliation: Scientific Center on Expertise of Medical Application Products of Minzdrav of Russia, Moscow, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Chaplenko
authors.affiliation: Sechenov First Moscow State Medical University, Research Institute for Uronephrology and Human Reproductive Health, Moscow, Russia.
authors.forename: T M
authors.initials: TM
authors.lastname: Zharikova
mesh_terms: D000818:Animals; D009130:Muscle, Smooth / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D001743:Urinary Bladder / Q000166:cytology* / Q000502:physiology; D019459:Urothelium / Q000166:cytology / Q000502:physiology
keywords: acellular matrix; bladder reconstruction agencies; tissue engineering