title: Toxic megacolon as a rare complication following atropine therapy due to organophosphate poisoning: A case report.
abstract: The main therapeutic basis for a case of organophosphate poisoning is a combination therapy which includes atropine as an anticholinergic drug and pralidoxime. If the poisoning is severe, a high dose of this combination of medicines may be needed, but this may cause serious side effects: paralytic ileus or even megacolon; however, these gastrointestinal events are very rare. Here, we report a case of organophosphate poisoning where atropine therapy was given and led to drug-associated toxic megacolon.
authors.affiliation: 1 Department of Forensic Medicine and Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Mostafazadeh
authors.affiliation: 2 Department of Forensic Medicine and Toxicology, Ardabil University of Medical Sciences, Ardabil, Iran.
authors.forename: Esmaeil
authors.initials: E
authors.lastname: Farzaneh
authors.affiliation: 3 Fellowship in Clinical Toxicology, Tabriz University of Medical Sciences,Tabriz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Paeezi
authors.affiliation: 4 Rasoul-e-Akram Hospital Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Nikkhah
mesh_terms: D000931:Antidotes / Q000009:adverse effects / Q000627:therapeutic use; D001285:Atropine / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D008297:Male; D008532:Megacolon, Toxic / Q000209:etiology*; D008875:Middle Aged; D062025:Organophosphate Poisoning / Q000150:complications* / Q000209:etiology* / Q000503:physiopathology; D011220:Pralidoxime Compounds / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000931:Antidotes; D011220:Pralidoxime Compounds; D001285:Atropine; C028797:pralidoxime
keywords: Organophosphate; atropine; poisoning; toxic megacolon