title: Modelling osteoblast adhesion on surface-engineered biomaterials: optimisation of nanophase grain size.
abstract: A double-layered model is proposed for numerically simulating osteoblast adhesion on surface-engineered biomaterials. The proposed model consists of molecular and cellular motions based on theoretical and experimental evidence and creates predictive simulations from sparse experimental data. The comparison of numerical solutions and experimental data reveals that the proposed model can explain the nonlinear behaviour of osteoblast adhesion on material surfaces in respect to nanophase grain size (0-100 nm). The model further provides insight into the optimisation of nanophase grain size on the surface of the biomaterial.
authors.affiliation: a Research School of Engineering, The Australian National University , Canberra , Australia.|c Department of Immunology and Infectious Diseases , The Australian National University , Canberra , Australia.
authors.forename: Song
authors.initials: S
authors.lastname: Chen
authors.affiliation: a Research School of Engineering, The Australian National University , Canberra , Australia.
authors.forename: Cheuk Y
authors.initials: CY
authors.lastname: Lee
authors.affiliation: b Trauma and Orthopaedic Research Laboratory , The Australian National University , Canberra , Australia.|c Department of Immunology and Infectious Diseases , The Australian National University , Canberra , Australia.
authors.forename: Rachel W
authors.initials: RW
authors.lastname: Li
authors.affiliation: b Trauma and Orthopaedic Research Laboratory , The Australian National University , Canberra , Australia.
authors.forename: Paul N
authors.initials: PN
authors.lastname: Smith
authors.affiliation: a Research School of Engineering, The Australian National University , Canberra , Australia.
authors.forename: Qing H
authors.initials: QH
authors.lastname: Qin
mesh_terms: D000537:Aluminum Oxide / Q000494:pharmacology; D001672:Biocompatible Materials / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry*; D009716:Numerical Analysis, Computer-Assisted; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects; D010316:Particle Size; D013499:Surface Properties; D014025:Titanium / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; C009495:titanium dioxide; D014025:Titanium; D000537:Aluminum Oxide
keywords: Mathematical model; cell adhesion; material surface; nanophase grain size; osteoblast