title: Marizomib for central nervous system-multiple myeloma.
abstract: Marizomib, a natural marine product, is an irreversible proteasome inhibitor currently under investigation in relapsed-refractory multiple myeloma (RRMM) and malignant glioma. Central nervous system-multiple myeloma (CNS-MM) is a rare manifestation of extra-medullary disease with few therapeutic options, highlighting the unmet clinical need in these patients. Marizomib demonstrated encouraging activity in RRMM and has emerging clinical activity in glioma, making it a potential CNS-MM therapeutic intervention. Herein, we present two patients with RRMM and CNS involvement who benefited from marizomib-based therapy. These cases provide the first proof of principle for further exploring marizomib in CNS-MM patients.
authors.affiliation: M&S Greenebaum Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
authors.forename: Ashraf
authors.initials: A
authors.lastname: Badros
authors.affiliation: M&S Greenebaum Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
authors.forename: Zeba
authors.initials: Z
authors.lastname: Singh
authors.affiliation: Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Binod
authors.initials: B
authors.lastname: Dhakal
authors.affiliation: M&S Greenebaum Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
authors.forename: Young
authors.initials: Y
authors.lastname: Kwok
authors.affiliation: Triphase Accelerator, San Diego, CA, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: MacLaren
authors.affiliation: Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Richardson
authors.affiliation: Triphase Accelerator, San Diego, CA, USA.
authors.forename: Mohit
authors.initials: M
authors.lastname: Trikha
authors.affiliation: Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Parameswaran
authors.initials: P
authors.lastname: Hari
mesh_terms: D000328:Adult; D016543:Central Nervous System Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007783:Lactones / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology; D011758:Pyrroles / Q000627:therapeutic use*
chemical_list: D007783:Lactones; D011758:Pyrroles; C475865:marizomib
keywords: central nervous system relapse; clinical studies; marizomib; multiple myeloma