title: [Chagas disease in the central nervous system in patient infected with HIV: diagnostic and therapeutic difficulties].
abstract: Chagas disease (ChD), caused by the protozoan Trypanosoma cruzi, is an endemic anthropozoonosis in Latin America, linked to deficients socio-economic and cultural aspects and is considered one of the neglected tropical diseases. We report a fatal case of Chagas disease reactivation with central nervous system involvement in a patient with HIV infection, whose diagnosis was confirmed by positive PCR (polymerase chain reaction) test of blood, with treatment response efficiency with benznidazol and management and etiologic treatment was difficult due to limited number of antitrypanosomal drugs and the occurrence of frequent and serious adverse effects.
authors.affiliation: Hospital de Enfermedades Infecciosas Francisco Javier Muñiz, Buenos Aires, Argentina.
authors.forename: Federico
authors.initials: F
authors.lastname: Simioli
authors.affiliation: Hospital de Enfermedades Infecciosas Francisco Javier Muñiz, Buenos Aires, Argentina.
authors.forename: Milagro
authors.initials: M
authors.lastname: Sánchez-Cunto
authors.affiliation: Instituto Nacional de Parasitología Dr. Mario Fatala Chaben, Buenos Aires, Argentina.
authors.forename: Elsa
authors.initials: E
authors.lastname: Velázquez
authors.affiliation: Hospital de Enfermedades Infecciosas Francisco Javier Muñiz, Buenos Aires, Argentina.
authors.forename: Susana
authors.initials: S
authors.lastname: Lloveras
authors.affiliation: Hospital de Enfermedades Infecciosas Francisco Javier Muñiz, Buenos Aires, Argentina.
authors.forename: Tomás
authors.initials: T
authors.lastname: Orduna
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000469:parasitology; D000328:Adult; D020808:Central Nervous System Protozoal Infections / Q000175:diagnosis* / Q000469:parasitology; D014355:Chagas Disease / Q000175:diagnosis*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging