title: Data Triumph at C.
abstract: Despite historical controversy, pharmacologic ascorbate is emerging as promising cancer therapy via pro-oxidant chemistry. In this issue of Cancer Cell, Schoenfeld et al. describe how intracellular iron pools and reactive oxygen species drive pharmacologic ascorbate's selective toxicity to cancer cells in vitro, in mice, and in humans.
authors.affiliation: Molecular and Clinical Nutrition Section, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1372, USA. Electronic address: markl@mail.nih.gov.
authors.forename: Mark
authors.initials: M
authors.lastname: Levine
authors.affiliation: Molecular and Clinical Nutrition Section, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1372, USA.
authors.forename: Pierre-Christian
authors.initials: PC
authors.lastname: Violet
mesh_terms: D000818:Animals; D001205:Ascorbic Acid; D006801:Humans; D007501:Iron; D051379:Mice; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species; D007501:Iron; D001205:Ascorbic Acid