title: The effects of septoplasty surgery on serum oxidative stress levels.
abstract: The aim of this study is to compare the total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) serum levels in patients who have undergone septoplasty (NSD). Forty-six patients (mean age 33.7) aged between 18 and 50 years who were diagnosed with nasal septal deviation (NSD) were included in the study. The TAS, TOS, and PON1 levels were compared in the serum samples obtained 1 month before the septoplasty and 3 months after surgery. There was a significant increase in mean TAS after septoplasty (1.041 vs. 1.124 mmol/L, p = 0.011). The mean TOS decreased significantly after septoplasty (20.631 vs. 5.946 mmol/L, p = 0.011). The mean pre- and postoperative PON1 levels were similar (326.93 ± 215.22 vs. 275.20 ± 167.76 U/L, p = 0.253). Increased TAS and decreased TOS after septoplasty show that patients with NSD are under oxidative stress that is relieved following septoplasty.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hitit University, üctutlar mah.ahcılar 16.sokak. Ada apt.10/15, 19000, Corum, Turkey. draekinci@hotmail.com.
authors.forename: Adnan
authors.initials: A
authors.lastname: Ekinci
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hitit University, üctutlar mah.ahcılar 16.sokak. Ada apt.10/15, 19000, Corum, Turkey.
authors.forename: Duran
authors.initials: D
authors.lastname: Karataş
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hitit University, üctutlar mah.ahcılar 16.sokak. Ada apt.10/15, 19000, Corum, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Yetiş
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Hitit University, Corum, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Demir
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Hitit University, üctutlar mah.ahcılar 16.sokak. Ada apt.10/15, 19000, Corum, Turkey.
authors.forename: Muge
authors.initials: M
authors.lastname: Ozcan
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000097:blood / Q000151:congenital / Q000503:physiopathology / Q000601:surgery*; D009300:Nasal Septum / Q000002:abnormalities* / Q000601:surgery*; D009667:Nose Deformities, Acquired; D016877:Oxidants / Q000097:blood; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011184:Postoperative Period; D057234:Preoperative Period; D012225:Rhinoplasty; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016877:Oxidants; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Paraoxonase; Septoplasty; Total antioxidant status; Total oxidant status