title: Treatment of infections during pregnancy: Progress and challenges.
abstract: BACKGROUND
  Emergence of Zika virus as a pathogen with important implications for perinatal outcomes highlights the need to identify safe and effective strategies for prevention and treatment of maternal infections.
  
  
  METHODS
  While substantial progress has been made in this area in recent years, significant regulatory and health systems barriers must still be overcome to identify and deliver evidence-based drug therapies for pregnant women.
  
  
  RESULTS
  We review progress and outstanding challenges associated with the identification and implementation of new treatment options for maternal infections.
  
  
  CONCLUSIONS
  We describe several strategies in use to optimize the application of existing evidence.Birth Defects Research 109:387-390, 2017.© 2017 Wiley Periodicals, Inc.
authors.affiliation: Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Noguchi
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Beigi
mesh_terms: D000328:Adult; D002675:Child, Preschool; D003140:Communicable Disease Control / Q000379:methods* / Q000639:trends; D003141:Communicable Diseases / Q000628:therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008288:Malaria / Q000517:prevention & control; D000072138:Mosquito Vectors; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology* / Q000628:therapy*; D011256:Pregnancy Outcome / Q000453:epidemiology; D016896:Treatment Outcome; D000071244:Zika Virus / Q000472:pathogenicity
keywords: infection; pharmacokinetics; pregnancy; registries