title: Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?
abstract: Amplification of the candidate oncogeneTLOC1/SEC62in tumors correlates with reduced patient survival. The recently reported role of SEC62 as an autophagy receptor that controls endoplasmic reticulum (ER) size and function might open new scenarios for understanding the phenotypes and treat SEC62hightumors, which are characterized by high ER stress tolerance.
authors.affiliation: Università della Svizzera italiana, Lugano, Switzerland; Institute for Research in Biomedicine, Bellinzona, Switzerland; Department of Biology, Swiss Federal Institute of Technology, Zurich, Switzerland.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Bergmann
authors.affiliation: Università della Svizzera italiana, Lugano, Switzerland; Institute for Research in Biomedicine, Bellinzona, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
authors.forename: Fiorenza
authors.initials: F
authors.lastname: Fumagalli
authors.affiliation: Università della Svizzera italiana, Lugano, Switzerland; Institute for Research in Biomedicine, Bellinzona, Switzerland; Department of Biology, Swiss Federal Institute of Technology, Zurich, Switzerland.
authors.forename: Marisa
authors.initials: M
authors.lastname: Loi
authors.affiliation: Università della Svizzera italiana, Lugano, Switzerland; Institute for Research in Biomedicine, Bellinzona, Switzerland; École Polytechnique Fédérale de Lausanne, School of Life Sciences, Lausanne, Switzerland.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Molinari
keywords: Autophagy receptor; ER-phagy; LIR; SEC62; TLOC1; cancer; endoplasmic reticulum; oncogene; recovER-phagy; selective autophagy; tumor