title: Pharmacotherapy and Immunotherapy of Conjunctival Tumors.
abstract: Conjunctiva and cornea tumors represent a large spectrum of conditions ranging from benign lesions to aggressive and life-threatening malignancies. Topical pharmacotherapies and immunotherapies have recently acquired a relevant role in the management of conjunctival tumors and, in the past 2 decades, there has been a shift from surgery alone toward the use of these agents, both as a sole therapy or as adjunct to surgery (before or after surgery). The 3 main agents that have been used for topical medical treatment of conjunctival tumors are mitomycin-C, 5-fluorouracil, and interferon-α2b. Advantages of topical pharmacotherapies and immunotherapies include the ability to treat the entire ocular surface and prevention of surgical side effects and complications. The aim of this review is to summarize the current use of topical pharmacotherapy and immunotherapy in the management of conjunctival tumors.
authors.affiliation: Department of Ophthalmology, University of Padova, Padova.|G.B. Bietti Foundation, IRCCS, Ocular Oncology and Toxicology Research Unit, Rome, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Midena
authors.affiliation: Department of Ophthalmology, University of Padova, Padova.
authors.forename: Luisa
authors.initials: L
authors.lastname: Frizziero
authors.affiliation: Department of Ophthalmology, University of Padova, Padova.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Parrozzani
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents
keywords: conjunctiva; cornea; immunotherapy; management of conjunctival tumors; topical pharmacotherapies