title: The Variation of Hemodynamic Parameters Through PiCCO in the Early Stage After Severe Burns.
abstract: To investigate early hemodynamics of severely burned patients via PiCCO and to discuss clinical significance of hemodynamic monitoring for burn shock resuscitation, 55 extensive burn patients were enrolled in this retrospective study. The fluid resuscitation was guided according to Chinese General Formula and adjusted with urinary output of 0.5-1.0 ml/h/kg as a resuscitation goal. All patients were diagnosed within a relatively stable condition during burn shock stage, and they received PiCCO monitoring within 6 hours after burn. The preload parameter intrathoracic blood volume index was low at first, then returned to normal. The flow parameter cardiac index and myocardial contractility parameter dPmax were gradually changed from low level in the early stage to high level in the fluid reabsorption stage. The afterload parameter systemic vascular resistance index had completely opposite tendency. The lung-related parameters extravascular lung water index and pulmonary vascular permeability index were roughly in the normal range. The change of cardiac index had a linear regression relationship with dPmax and systemic vascular resistance index but had no significant relationship with intrathoracic blood volume index. Under effective fluid resuscitation, the early hemodynamics after burn is still in dynamically changing status, characterized as transition from low cardiac output (CO)-high vascular resistance in early shock stage to high CO-low vascular resistance in fluid reabsorption stage. CO mainly depends on the myocardial contractility and vascular resistance, but not on the blood volume. Excessive fluid resuscitation cannot get normal CO. The normal value of hemodynamics cannot be used as end point of burn shock resuscitation. Dynamic observation of hemodynamics is of great importance.
authors.affiliation: From the *Department of Burn Surgery, The Second Military Medical University affiliated Changhai Hospital, Shanghai, China; †Department of Plastic Surgery, The First People's Hospital of Zhengzhou, Zhengzhou, Henan, China; ‡No. 73901 Troop of PLA, Shanghai, China; and §No. 72510 Troop of PLA, Zhanjiang, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Gong
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: He
authors.forename: Gong-Cheng
authors.initials: GC
authors.lastname: Liu
authors.forename: Shi-Hui
authors.initials: SH
authors.lastname: Zhu
authors.forename: Guang-Yi
authors.initials: GY
authors.lastname: Wang
authors.forename: Zhao-Fan
authors.initials: ZF
authors.lastname: Xia
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D002302:Cardiac Output / Q000502:physiology*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D008875:Middle Aged; D011674:Pulse; D012189:Retrospective Studies; D012769:Shock / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D013997:Time Factors