title: Changes in blood anti-oxidation enzyme levels in MPTP-treated monkeys.
abstract: Oxidative stress has been implicated in a range of neurodegenerative diseases, in particular, Parkinson's disease (PD). However, the pathogenic mechanism of its influence on PD progression remains unclear. In order to clarify this, PD models are generated by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intramuscular injection in eight rhesus monkeys. During the of progress PD pathogenesis, the activities of some major antioxidant enzymes, such as serum superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione-s-transferase (GST), were measured, which show continuously decrease. While, the GSH and MDA content, as well as the expression of gamma-glutamylcysteine synthetase (GCS) and glutathione-s-transferase pi (GST-pi) exhibit robust increase. Taken together, this study shows the dynamic changes of antioxidant enzymes and lipid peroxidation in blood of PD monkeys during its progress, which will be important for the diagnosis and treatment of PD.
authors.affiliation: Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
authors.forename: Like
authors.initials: L
authors.lastname: Li
authors.affiliation: Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
authors.forename: Liangqin
authors.initials: L
authors.lastname: Shi
authors.affiliation: Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Liu
authors.affiliation: Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
authors.forename: Qihui
authors.initials: Q
authors.lastname: Luo
authors.affiliation: Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.affiliation: Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Liu
authors.affiliation: Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Chen
authors.affiliation: National Experimental Macaque Reproduce Laboratory, Ya'an, Sichuan 625014, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Laboratory of Animal Disease Model, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, China; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan 625014, China. Electronic address: chzhli75@163.com.
authors.forename: Zhengli
authors.initials: Z
authors.lastname: Chen
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage; D000818:Animals; D005979:Glutathione Peroxidase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D007273:Injections, Intramuscular; D015227:Lipid Peroxidation; D008253:Macaca mulatta; D009043:Motor Activity / Q000187:drug effects; D018384:Oxidative Stress; D020734:Parkinsonian Disorders / Q000097:blood* / Q000201:enzymology* / Q000473:pathology; D065842:Pars Compacta / Q000187:drug effects / Q000473:pathology; D012333:RNA, Messenger / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D012333:RNA, Messenger; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase
keywords: Antioxidant; Behavior; MPTP; Monkey; Oxidative stress; Parkinson’s disease