title: Trends in occupational disparities for exposure to carcinogenic, mutagenic and reprotoxic chemicals in France 2003-10.
abstract: To explore trends in social and occupational inequalities in terms of exposure to carcinogenic, mutagenic and reprotoxic chemicals (CMR) for French employees. Our study assessed data from the French national cross-sectional survey of occupational hazards (SUMER) that was conducted in 2003 and 2010. We included all of the 27 CMR agents that were classified by the International Agency for Research on Cancer or European Union regulations as being known or presumed to have CMR potential in humans. Trends in prevalence and degree of exposure were examined using multilevel logistic regression analysis. The number of employees exposed to CMR agents decreased by 17.5% between 2003 and 2010. The only CMR entities for which exposure rates increased are not considered to be proven CMRs according to the European Union regulations. With the exception of apprentices, there was an overall decrease in exposure prevalence for all employees. This decrease occurred, however, to different extents. The decrease in the risk of exposure to CMR agents was much greater for those on permanent contracts, managers, and in enterprises with more than 500 employees. Nonetheless, in situations where there was potential for exposure, companies with fewer than 10 employees were in fact able to decrease the degree of risk more than the others. Our results confirm the relevance of reinforcing regulatory restrictions for CMR products, while also indicating that monitoring of trends in disparities will allow public health policy makers to better evaluate progress made toward reducing disparities that affect vulnerable populations.
authors.affiliation: Laboratoire SAF, ISFA, Université Lyon, Université Lyon 1, Lyon, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Havet
authors.affiliation: ENS Lyon, GATE-UMR 5824-CNRS, Université Lyon, Lyon, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Penot
authors.affiliation: GATE-UMR 5824-CNRS, Cancer Centre Léon Bérard, Direction de la Recherche Clinique et de l'innovation, Université Lyon, Lyon, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Morelle
authors.affiliation: GATE-UMR 5824-CNRS, Cancer Centre Léon Bérard, Direction de la Recherche Clinique et de l'innovation, Université Lyon, Lyon, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Perrier
authors.affiliation: IFSTTAR, UMRESTTE, Centre Hospitalier Lyon Sud Service des Maladies Professionnelles, Hospices Civils de Lyon, UMR-T9405, Université Lyon, Université Lyon 1, Lyon, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Charbotel
authors.affiliation: Department Cancer and Environment, Centre Léon Bérard, Université Lyon, Lyon, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Fervers
mesh_terms: D000293:Adolescent; D000328:Adult; D002273:Carcinogens / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000008:administration & dosage*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D002273:Carcinogens; D009153:Mutagens