title: Self-Assembled Novel BODIPY-Based Palladium Supramolecules and Their Cellular Localization.
abstract: Four new palladium metal supramolecules with triangular/square architectures derived from boron dipyrromethane (BODIPY) ligands were synthesized by self-assembly and fully characterized by1H and31P NMR, electrospray ionization mass spectrometry, and single-crystal X-ray diffraction. These supramolecules were more cytotoxic to brain cancer (glioblastoma) cells than to normal lung fibroblasts. Their cytotoxicity to the glioblastoma cells was higher than that of a benchmark metal-based chemotherapy drug, cisplatin. The characteristic green fluorescence of the BODIPY ligands in these supramolecules permitted their intracellular visualization using confocal microscopy, and the compounds were localized in the cytoplasm and on the plasma membrane.
authors.forename: Gajendra
authors.identifier: http://orcid.org/0000-0002-0098-8288
authors.initials: G
authors.lastname: Gupta
authors.affiliation: Division of Molecular Medicine, Bose Institute , P-1/12, CIT Scheme-VII M, Kolkata 700054, India.
authors.forename: Abhishek
authors.identifier: http://orcid.org/0000-0002-7241-5120
authors.initials: A
authors.lastname: Das
authors.forename: Kyoung Chul
authors.initials: KC
authors.lastname: Park
authors.forename: Artur
authors.initials: A
authors.lastname: Tron
authors.affiliation: Convergence Materials Laboratory, Korea Institute of Energy Research , Daejeon 305-343, Republic of Korea.
authors.forename: Hyunuk
authors.identifier: http://orcid.org/0000-0002-2668-8267
authors.initials: H
authors.lastname: Kim
authors.forename: Junyoung
authors.identifier: http://orcid.org/0000-0001-9965-5709
authors.initials: J
authors.lastname: Mun
authors.affiliation: Division of Molecular Medicine, Bose Institute , P-1/12, CIT Scheme-VII M, Kolkata 700054, India.
authors.forename: Nripendranath
authors.initials: N
authors.lastname: Mandal
authors.affiliation: Department of Chemistry, University of Ulsan , Ulsan 680-749, Republic of Korea.
authors.forename: Ki-Whan
authors.initials: KW
authors.lastname: Chi
authors.forename: Chang Yeon
authors.identifier: http://orcid.org/0000-0002-1131-9071
authors.initials: CY
authors.lastname: Lee
mesh_terms: D001896:Boron Compounds / Q000737:chemistry / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000187:drug effects; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008024:Ligands; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010165:Palladium / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D008024:Ligands; D046911:Macromolecular Substances; D009942:Organometallic Compounds; D010165:Palladium