title: Prognostic Effect of Complex Karyotype, Monosomal Karyotype, and Chromosome 17 Abnormalities in B-Cell Acute Lymphoblastic Leukemia.
abstract: The effect of monosomal karyotype (MK), complex karyotype (CK), and chromosome 17 abnormalities (abnl 17) on prognosis in B-cell acute lymphoid leukemia (B-ALL) has not yet been established.
  
  
  
  We conducted a retrospective analysis of prognostic factors on 237 adult patients with B-ALL treated at our institution.
  
  
  
  Older age (older than 60 years), higher white blood cell count (> 30), and abnl 17 were associated with shorter overall survival in univariate analysis, but multivariable analysis only identified older age as an independent poor prognostic actor. There was a significant correlation between abnl 17 and older age.
  
  
  
  In contrast to the patients with acute myeloid leukemia, our results show that MK and CK do not play a predictive role in patients with B-ALL, but further study is required to determine whether specific changes on chromosome 17 might have prognostic value when investigated separately.
authors.affiliation: Department of Laboratory Hematology and Pathology, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada.
authors.forename: Priya
authors.initials: P
authors.lastname: Khoral
authors.affiliation: Department of Biostatistics, University Health Network, Toronto, Ontario, Canada.
authors.forename: Eshetu G
authors.initials: EG
authors.lastname: Atenafu
authors.affiliation: Department of Laboratory Hematology and Pathology, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Craddock
authors.affiliation: Department of Hematology and Medical Oncology, University Health Network, Toronto, Ontario, Canada.
authors.forename: Aaron
authors.initials: A
authors.lastname: Schimmer
authors.affiliation: Department of Laboratory Hematology and Pathology, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada. Electronic address: hong.chang@uhn.on.ca.
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000473:pathology*; D002648:Child; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D006801:Humans; D059785:Karyotype; D007621:Karyotyping / Q000379:methods; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
keywords: Cytogenetic risk analysis; Multivariate analysis; Oncogenes; Risk groups; p53