title: Calofolic acids A-F, chromanones from the bark of Calophyllum scriblitifolium with vasorelaxation activity.
abstract: Vasorelaxation activity guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of 6 chromanones (calofolic acids A-F, 1-6). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. All isolated chromanones showed dose-dependent vasorelaxation activity on isolated rat aorta.
authors.affiliation: Hoshi University Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan.
authors.forename: Alfarius Eko
authors.initials: AE
authors.lastname: Nugroho
authors.affiliation: Hoshi University Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan.
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Sasaki
authors.affiliation: Hoshi University Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Kaneda
authors.affiliation: Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: A Hamid A
authors.initials: AHA
authors.lastname: Hadi
authors.affiliation: Hoshi University Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan. Electronic address: moritah@hoshi.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects; D029759:Calophyllum / Q000737:chemistry* / Q000378:metabolism; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D002867:Chromones; D010936:Plant Extracts; D014665:Vasodilator Agents
keywords: Calofolic acids; Calophyllum scriblitifolium; Chromanones; Vasorelaxation activity