title: Bisphenol A Exposure during Pregnancy Alters the Mortality and Levels of Reproductive Hormones and Genes in Offspring Mice.
abstract: The present study investigated the reproductive toxicity of bisphenol A (BPA) exposure to the mother on the offspring mice. BPA was given to pregnant mice at 50 mg/kg, 500 mg/kg, and 2500 mg/kg BW BPA daily by gavage during the whole gestation period. The offspring mice were sacrificed at 8 weeks of age. Results showed that exposure of BPA to the mother increased the mortality (P< 0.05). Maternal exposure of BPA reduced the levels of T (♂) and FSH (♀) (P< 0.01) and elevated E2(♀) level in the adult offspring (P< 0.01). BPA exposure caused testicular damage as shown by less Leydig cells and ovarian injury as shown by more vacuoles and less corpus granules in the adult offspring mice. Immunohistochemistry revealed that maternal exposure of BPA increased Bax and decreased Bcl-2 at the protein levels in testicular and ovary tissues in the offspring mice. BPA significantly reduced the expression of StAR in male offspring (P< 0.05). Interestingly, the mRNA levels of Cyp11a were significantly decreased in 50 mg/kg groups and were increased in 500 mg/kg group in the males. Reduced Kitlg and elevated Amh at the mRNA levels were detected in the female offspring.
authors.affiliation: College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China.
authors.forename: Shuang
authors.identifier: 0000-0002-3271-9541
authors.initials: S
authors.lastname: Ma
authors.affiliation: College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China.
authors.forename: Wanyu
authors.initials: W
authors.lastname: Shi
authors.affiliation: College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China.
authors.forename: Xiaodan
authors.identifier: 0000-0001-8133-0455
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China.
authors.forename: Pengyan
authors.identifier: 0000-0002-9981-7648
authors.initials: P
authors.lastname: Song
authors.affiliation: College of Animal Science and Technology, Agricultural University of Hebei, Baoding 071001, China; College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China.
authors.forename: Xiuhui
authors.identifier: 0000-0001-6757-3776
authors.initials: X
authors.lastname: Zhong
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D004968:Estrogens, Non-Steroidal / Q000378:metabolism; D005260:Female; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D010053:Ovary / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012098:Reproduction / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000293:injuries / Q000378:metabolism*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds