title: OnabotulinumtoxinA injections in detrusor facilitate self-catheterisation in a patient with paraplegia and bladder outlet dyssynergia.
abstract: This case report describes the case of improvement of clean intermittent catheterisation procedures after each intradetrusor administration of onabotulinumtoxinA in a 45-year-old man with L1 paraplegia with neurogenic detrusor overactivity and bladder outlet dyssynergia.On three occasions, improvement on clean intermittent catheterisation procedures appeared 10 to 14 days after intradetrusor injections of onabotulinumtoxinA and lasted for 9 months. We hypothesise a possible influence of intravesical injections of onabotulinumtoxinA on the storage reflex. We also discuss the possibility of a dispersion of onabotulinumtoxinA towards contiguous structures such as the urethral sphincter.
authors.affiliation: Department of Urology, Universitair Ziekenhuis Gent, Gent, Belgium.
authors.forename: François
authors.initials: F
authors.lastname: Hervé
authors.affiliation: Department of Physical Medicine and Orthopedic Surgery, Universitair Ziekenhuis Gent, Gent, Belgium.
authors.forename: Annick
authors.initials: A
authors.lastname: Viaene
authors.affiliation: Department of Urology, Universitair Ziekenhuis Gent, Gent, Belgium karel.everaert@uzgent.be.
authors.forename: Karel
authors.initials: K
authors.lastname: Everaert
mesh_terms: D000283:Administration, Intravesical; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000150:complications; D013119:Spinal Cord Injuries / Q000150:complications; D014521:Urethra; D001750:Urinary Bladder, Neurogenic / Q000628:therapy*; D053201:Urinary Bladder, Overactive / Q000628:therapy*; D014546:Urinary Catheterization / Q000379:methods*; D014549:Urinary Incontinence / Q000628:therapy*
chemical_list: D019274:Botulinum Toxins, Type A
keywords: Catheter care; Drugs and medicines; Neurological injury; Neurology, Continence; Neurology, Spinal cord; Urinary and genital tract disorder; Urology