title: Association between high birth weight and hypertension in children and adolescents: a cross-sectional study in China.
abstract: This study aims to examine the relationship between high birth weight (HBW) and blood pressure and assess whether HBW leads to increased hypertension during childhood and adolescence. All the participants aged 6-18 years with HBW were selected from a cross-sectional study from seven provinces in China. Nine thousand nine hundred and sixty-two children were randomly sampled with matched data. Basic information of students was collected with a standardized student and guardian questionnaire. High blood pressure was defined according to sex-, age- and height-specific references. Multi-variance logistic regression was used to estimate the odds ratio (OR) of high blood pressure and HBW after adjustment for confounding factors. The overall mean of systolic BP and diastolic BP in HBW group were significantly higher than normal group in both genders and urban/rural area. Corresponding overall prevalence of high BP, elevated SBP and elevated DBP in HBW group were also higher than normal group in both genders, respectively (boys: 19.41% vs 16.16%; 10.12% vs 8.16%; 14.86% vs 12.71%; girls: 14.95% vs 12.66%; 8.19% vs 6.56%; 11.13% vs 9.86%). In addition, birth weight was positively associated with high BP, elevated SBP and elevated DBP in children and adolescents of both sexes (boys: OR 1.25, 1.27, 1.20; girls: OR 1.21, 1.27, 1.15). However, the positive association was attenuated and even reversed after adjustment for potential confounding variables. In this study, HBW may lead to higher childhood blood pressure, but no association between HBW and childhood hypertension was observed.
authors.affiliation: School of Public Health &Institute of Child and Adolescent Health, Peking University, Beijing, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Dong
authors.affiliation: School of Public Health &Institute of Child and Adolescent Health, Peking University, Beijing, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zou
authors.affiliation: School of Public Health &Institute of Child and Adolescent Health, Peking University, Beijing, China.
authors.forename: Z P
authors.initials: ZP
authors.lastname: Yang
authors.affiliation: School of Public Health &Institute of Child and Adolescent Health, Peking University, Beijing, China.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Wang
authors.affiliation: Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Jing
authors.affiliation: Department of Maternal and Child Health, School of Public Health, Central South University, Changsha, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Luo
authors.affiliation: School of Public Health, Tianjin Medical University, Tianjin, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Luo
authors.affiliation: School of Public Health and Management, Chongqing Medical University, Chongqing, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Public Health, Ningxia Medical University, Yinchuan, China.
authors.forename: H P
authors.initials: HP
authors.lastname: Zhao
authors.affiliation: Liaoning Health and Family Planning Inspection, Shenyang, China.
authors.forename: D H
authors.initials: DH
authors.lastname: Pan
authors.affiliation: School of Public Health &Institute of Child and Adolescent Health, Peking University, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001724:Birth Weight; D001794:Blood Pressure; D016009:Chi-Square Distribution; D002648:Child; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors