title: Dysregulation of LncRNAs in Placenta and Pathogenesis of Preeclampsia.
abstract: BACKGROUND
  Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain largely undefined. The placenta plays a critical role in the fetal development by carrying out the barrier, fetal-maternal exchange, and endocrine functions during pregnancy. Accumulated data indicated that the expression of multiple long noncoding RNA (LncRNA) is dysregulated in preeclamptic placentas. Moreover, manipulation of LncRNA expression led to functional alterations in trophoblast cell cultures, including changes in proliferation, differentiation, apoptosis, and migration.
  
  
  OBJECTIVE
  This article reviews published data on this subject and provides detailed information on the regulation and function of LncRNAs IGF2/H19, MEG3, SPRY4-IT1, HOTAIR, MALAT1, and FLT1P1 and CEACAMP8 in placental trophoblasts. The potential mechanisms underlying the action of these LncRNAs are also discussed to facilitate a better understanding on the potential role of these LncRNAs for the pathogenesis of preeclampsia.
  
  
  CONCLUSIONS
  It is elaborated that some lncRNAs probably contribute to the pathogenesis of preeclampsia through methylation, Notch-EGFL7 signaling pathway and Wnt/β-catenin pathway.
authors.affiliation: Department of Obstetrics, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Xuejing
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Obstetrics, Lianyungang Maternity and Child Healthcare Hospital of Jiangsu, Lianyungang 222006, China.
authors.forename: Xiucui
authors.initials: X
authors.lastname: Luo
authors.affiliation: Laboratory of the Animal Center, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Quansheng
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Yuhuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 71004, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Department of Obstetrics, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Long
mesh_terms: D017209:Apoptosis; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D010920:Placenta / Q000737:chemistry / Q000166:cytology*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D062085:RNA, Long Noncoding / Q000235:genetics*; D015398:Signal Transduction; D014327:Trophoblasts / Q000166:cytology
chemical_list: D062085:RNA, Long Noncoding
keywords: LncRNA; Preeclampsia; non-coding RNA; pathogenesis; placenta; trophoblast