title: Radiologically Isolated Syndrome: MR Imaging Features Suggestive of Multiple Sclerosis Prior to First Symptom Onset.
abstract: Remarkable advances in the understanding of the biology of multiple sclerosis have been achieved through the use of conventional and novel MR imaging techniques of the central nervous system. With improvements in access by patients and utilization of MR imaging technology in health care, an increasing number of unanticipated structural anomalies are being appreciated. In certain instances, white matter abnormalities within the brain and spinal cord are discovered in subjects with no prior history of neurologic symptoms supportive of inflammatory demyelinating events.
authors.affiliation: Neuroinnovation Program, Multiple Sclerosis and Neuroimmunology Imaging Program, Department of Neurology and Neurotherapeutics, Clinical Center for Multiple Sclerosis, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8806, USA. Electronic address: darin.okuda@utsouthwestern.edu.
authors.forename: Darin T
authors.initials: DT
authors.lastname: Okuda
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D013116:Spinal Cord / Q000000981:diagnostic imaging / Q000473:pathology
keywords: MR imaging; Multiple sclerosis; Radiologically isolated syndrome