title: Physicochemical characterizations of functional hybrid liposomal nanocarriers formed using photo-sensitive lipids.
abstract: With recent advances in the field of diagnostics and theranostics, liposomal technology has secured a fortified position as a potential nanocarrier. Specifically, radiation/photo-sensitive liposomes containing photo-polymerizable cross-linking lipids are intriguing as they can impart the vesicles with highly interesting properties such as response to stimulus and improved shell stability. In this work, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine (DTPE) is used as a photo-polymerizable lipid to form functional hybrid-liposomes as it can form intermolecular cross-linking through the diacetylenic groups. Hybrid-liposomes were formulated using mixtures of DTPE and saturated lipids of different chain lengths (dipalmitoylphosphatidylcholine (DPPC) and dimirystoilphosphatidylcholine (DMPC)) at different molar ratios. The physico-chemical characteristics of the liposomes has been studied before and after UV irradiation using a combination of techniques: DSC, QCM-D and solid-state NMR. The results signify the importance of a subtle modification in alkyl chain length on the phase behavior of the hybrid-liposomes and on the degree of crosslinking in the shell.
authors.affiliation: Institute for Materials Research (IMO), Hasselt University, Wetenschapspark 1 and Agoralaan D, 3590 Diepenbeek, Belgium.|IMEC, associated lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Sumit
authors.initials: S
authors.lastname: Kumar Pramanik
authors.affiliation: Institute for Materials Research (IMO), Hasselt University, Wetenschapspark 1 and Agoralaan D, 3590 Diepenbeek, Belgium.|IMEC, associated lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Patricia
authors.initials: P
authors.lastname: Losada-Pe Rez
authors.affiliation: Institute for Materials Research (IMO), Hasselt University, Wetenschapspark 1 and Agoralaan D, 3590 Diepenbeek, Belgium.|IMEC, associated lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Gunter
authors.initials: G
authors.lastname: Reekmans
authors.affiliation: Institute for Materials Research (IMO), Hasselt University, Wetenschapspark 1 and Agoralaan D, 3590 Diepenbeek, Belgium.|IMEC, associated lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Robert
authors.initials: R
authors.lastname: Carleer
authors.affiliation: Institute for Materials Research (IMO), Hasselt University, Wetenschapspark 1 and Agoralaan D, 3590 Diepenbeek, Belgium.|IMEC, associated lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: D'Olieslaeger
authors.affiliation: Institute for Materials Research (IMO), Hasselt University, Wetenschapspark 1 and Agoralaan D, 3590 Diepenbeek, Belgium.|IMEC, associated lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Dirk
authors.initials: D
authors.lastname: Vanderzande
authors.affiliation: Institute for Materials Research (IMO), Hasselt University, Wetenschapspark 1 and Agoralaan D, 3590 Diepenbeek, Belgium.|IMEC, associated lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Adriaensens
authors.affiliation: Institute for Materials Research (IMO), Hasselt University, Wetenschapspark 1 and Agoralaan D, 3590 Diepenbeek, Belgium.|IMEC, associated lab IMOMEC, Wetenschapspark 1, 3590 Diepenbeek, Belgium.
authors.forename: Anitha
authors.initials: A
authors.lastname: Ethirajan
mesh_terms: D055598:Chemical Phenomena; D004337:Drug Carriers / Q000737:chemistry*; D008027:Light; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D055668:Photochemical Processes; D000068936:Theranostic Nanomedicine; D013818:Thermogravimetry
chemical_list: D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes