title: Colonization resistance: The deconvolution of a complex trait.
abstract: Carbapenemase-producing Enterobacteriaceae are an emerging threat to hospitals worldwide, and antibiotic exposure is a risk factor for developing fecal carriage that may lead to nosocomial infection. Here, we review how antibiotics reduce colonization resistance against Enterobacteriaceae to pinpoint possible control points for curbing their spread. Recent work identifies host-derived respiratory electron acceptors as a critical resource driving a post-antibiotic expansion of Enterobacteriaceae within the large bowel. By providing a conceptual framework for colonization resistance against Enterobacteriaceae, these mechanistic insights point to the metabolism of epithelial cells as a possible target for intervention strategies.
authors.affiliation: From the Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California 95616.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Olsan
authors.affiliation: From the Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California 95616.
authors.forename: Mariana X
authors.initials: MX
authors.lastname: Byndloss
authors.affiliation: From the Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California 95616.
authors.forename: Franziska
authors.initials: F
authors.lastname: Faber
authors.affiliation: From the Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California 95616.
authors.forename: Fabian
authors.initials: F
authors.lastname: Rivera-Chávez
authors.affiliation: From the Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California 95616.
authors.forename: Renée M
authors.initials: RM
authors.lastname: Tsolis
authors.affiliation: From the Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California 95616 ajbaumler@ucdavis.edu.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Bäumler
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001424:Bacterial Infections / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000235:genetics; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007422:Intestines / Q000382:microbiology* / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Escherichia coli (E. coli); Klebsiella pneumonia; Salmonella enterica; antibiotic resistance; antibiotics; microbiome