title: Barriers preventing the adoption of comprehensive cancer genomic profiling in the clinic.
abstract: Comprehensive cancer genomic profiling provides the opportunity to expose the various molecular aberrations potentially driving tumor progression. Consequently, the identity of these genetic drivers can be utilized to match a patient to the most appropriate targeted therapy, thereby increasing the probability of improved clinical outcome. Despite its capability of informing patient care, the adoption of comprehensive cancer genomic profiling in the clinic has not been widespread. The barriers surrounding its universal acceptance are attributed to both physician and patient perspectives. Areas covered: The following report discusses the various obstacles in place, including those related to clinical utility, education, insurance coverage, and clinical trials, which can deter physicians and patients from utilizing genomic profiling for therapeutic decision-making. Expert commentary: The authors review the recent growth and potential of clinical utility studies over the last two years, provide a suggestive framework for educational support, and comment on the use of social media to enhance clinical trial recruitment.
authors.affiliation: a The Jackson Laboratory for Genomic Medicine, Clinical Genomics , Farmington , CT , USA.
authors.forename: Cara M
authors.initials: CM
authors.lastname: Statz
authors.affiliation: a The Jackson Laboratory for Genomic Medicine, Clinical Genomics , Farmington , CT , USA.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Patterson
authors.affiliation: a The Jackson Laboratory for Genomic Medicine, Clinical Genomics , Farmington , CT , USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Mockus
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000592:standards; D003365:Costs and Cost Analysis; D005820:Genetic Testing / Q000191:economics / Q000706:statistics & numerical data*; D015894:Genome, Human; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D057285:Precision Medicine / Q000191:economics / Q000523:psychology / Q000706:statistics & numerical data*; D017422:Sequence Analysis, DNA / Q000191:economics / Q000706:statistics & numerical data
chemical_list: D014408:Biomarkers, Tumor
keywords: Cancer; clinical utility; genomic profiling; next generation sequencing; targeted therapy