title: Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members.
authors.affiliation: Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States.
authors.forename: Phuong
authors.initials: P
authors.lastname: Pham
authors.affiliation: Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States.
authors.forename: Samir A
authors.initials: SA
authors.lastname: Afif
authors.affiliation: Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan; Laboratory of Host Defence, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan; World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Shimoda
authors.affiliation: Laboratory of Host Defence, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan; World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Maeda
authors.affiliation: World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita 565-0871, Japan; Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sakaguchi
authors.affiliation: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, United States.
authors.forename: Lars C
authors.initials: LC
authors.lastname: Pedersen
authors.affiliation: Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, United States; Department of Chemistry, University of Southern California, Los Angeles, CA 90089, United States. Electronic address: mgoodman@usc.edu.
authors.forename: Myron F
authors.initials: MF
authors.lastname: Goodman
mesh_terms: D000071478:APOBEC Deaminases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D005810:Multigene Family; D009154:Mutation; D054730:Protein Interaction Domains and Motifs; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D000071478:APOBEC Deaminases
keywords: AID X-ray crystal structure; Antibody diversity; C-deamination motif selectivity; IgV somatic hypermutation