title: Pd-Catalyzed Autotandem Reactions with N-Tosylhydrazones. Synthesis of Condensed Carbo- and Heterocycles by Formation of a C-C Single Bond and a C═C Double Bond on the Same Carbon Atom.
abstract: A new Pd-catalyzed autotandem reaction is introduced that consists of the cross-coupling of a benzyl bromide with a N-tosylhydrazone followed by an intramolecular Heck reaction with an aryl bromide. During the process, a single and a double C-C bond are formed on the same carbon atom. Two different arrangements for the reactive functional groups are possible, rendering great flexibility to the transformation. The same strategy led to 9-methylene-9H-fluorenes, 9-methylene-9H-xanthenes, 9-methylene-9,10-dihydroacridines, and also dihydropyrroloisoquinoline and dihydroindoloisoquinoline derivatives.
authors.affiliation: Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo , c/Julián Clavería 8, Oviedo 33006, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Paraja
authors.affiliation: Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo , c/Julián Clavería 8, Oviedo 33006, Spain.
authors.forename: Carlos
authors.identifier: 0000-0002-6246-2994
authors.initials: C
authors.lastname: Valdés