title: Long non-coding RNA GAS5 inhibits tumorigenesis via miR-137 in melanoma.
abstract: Melanoma is the leading cause of death in patients with skin cancer. In the present study, we aimed to prove the functions and molecular mechanisms of lncRNA-GAS5 in melanoma. Herein, we found that the expression of GAS5 was down-regulated in melanoma tissues compared to adjacent normal tissues. GAS5 was significantly associated with distal metastasis and TNM stage in melanoma. Furthermore, we found that GAS5 suppressed melanoma cell proliferation, migration and invasion. Then, we found thatmiR-137 was decreased in melanoma tissues compared to adjacent normal tissues and was correlated with GAS5. Using a luciferase reporter gene assay, we also demonstrated that GAS5 positively regulated miR-137 transcription. Finally, we suggested that GAS5 inhibited the growth of melanoma through miR-137in vivo. Therefore, our research demonstrated that the GAS5/miR-137 axis could be a potential therapeutic target for the treatment of melanoma.
authors.affiliation: Department of Burns and Plastic Surgery, The General Hospital of Jinan Military Command 25 Shifan Road, Jinan 250031, Shandong, P. R. China.
authors.forename: Donghui
authors.initials: D
authors.lastname: Bian
authors.affiliation: Department of Burns and Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University 105 Jiefang Road, Jinan 250013, Shandong, P. R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Burns and Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University 105 Jiefang Road, Jinan 250013, Shandong, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Burns and Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University 105 Jiefang Road, Jinan 250013, Shandong, P. R. China.
authors.forename: Peilong
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Burns and Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University 105 Jiefang Road, Jinan 250013, Shandong, P. R. China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Song
keywords: lncRNA-GAS5; melanoma; miR-137; migration and invasion; proliferation