title: Cardiac hyaluronan may be associated with the persistence of atrial fibrillation.
abstract: Hyaluronan (HA), a primary component of the extracellular matrix, is associated with several cardiovascular diseases. However, its precise cardiac origin and role in atrial fibrillation (AF) remain unclear. We investigated chamber-specific HA levels in patients with paroxysmal AF (PAF) or persistent AF (PSAF). The levels of HA, a diacron-reactive oxygen metabolite (dROM) as a marker for oxidative stress, at different cardiac sites, and peripheral brain natriuretic peptide (BNP) levels were measured in patients with PAF (n = 50) or PSAF (n = 35). HA levels in the coronary sinus (CS-HA) were significantly higher than those other sites, in both PAF and PSAF patients, and CS-HA levels were significantly higher in PSAF patients than in PAF patients [37.1 (interquartile range, 31.2-48.3) vs. 30.6 (23.7-40.2) pg/mL, P < 0.01]. CS-HA levels were correlated with CS-dROM levels and peripheral BNP levels in PSAF patients (r = 0.417, P = 0.03 and r = 0.579, P < 0.001, respectively), but not in PAF patients (r = -0.115, P = 0.421 and r = 0.048, P = 0.740, respectively). CS-HA levels were elevated in both PAF and PSAF patients and were correlated with cardiac oxidative stress and BNP levels in PSAF patients. Cardiac HA may be associated with the persistence of AF.
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Okada
authors.affiliation: Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. ykashima@shinshu-u.ac.jp.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kashima
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tomita
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takeuchi
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Oguchi
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshie
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Shoin
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Morio
authors.initials: M
authors.lastname: Shoda
authors.affiliation: Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nitta
authors.affiliation: Department of Cardiovascular Medicine, Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kuwahara
authors.affiliation: Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
mesh_terms: D001281:Atrial Fibrillation / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000378:metabolism; D004452:Echocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D006820:Hyaluronic Acid
keywords: Atrial fibrillation; Brain natriuretic peptide; Hyaluronan; Inflammation; Oxidative stress