title: Physical activity and not sedentary time per se influences on clustered metabolic risk in elderly community-dwelling women.
abstract: BACKGROUND
  Whether amount of time spent in sedentary activities influences on clustered metabolic risk in elderly, and to what extent such an influence is independent of physical activity behavior, remain unclear. Therefore, the aim of the study was to examine cross-sectional associations of objectively assessed physical activity and sedentary behavior on metabolic risk outcomes in a sample of elderly community-dwelling women.
  
  
  METHODS
  Metabolic risk outcomes including waist circumference, systolic and diastolic blood pressures, fasting levels of plasma glucose, HDL-cholesterol and triglycerides were assessed in 120 community-dwelling older women (65-70 yrs). Accelerometers were used to retrieve daily sedentary time, breaks in sedentary time, daily time in light (LPA) and moderate-to-vigorous physical activity (MVPA), and total amount of accelerometer counts. Multivariate regression models were used to examine influence of physical activity and sedentary behavior on metabolic risk outcomes including a clustered metabolic risk score.
  
  
  RESULTS
  When based on isotemporal substitution modeling, replacement of a 10-min time block of MVPA with a corresponding time block of either LPA or sedentary activities was associated with an increase in clustered metabolic risk score (β = 0.06 to 0.08, p < 0.05), and an increase in waist circumference (β = 1.78 to 2.19 p < 0.01). All associations indicated between sedentary time and metabolic risk outcomes were lost once variation in total accelerometer counts was adjusted for.
  
  
  CONCLUSIONS
  Detrimental influence of a sedentary lifestyle on metabolic health is likely explained by variations in amounts of physical activity rather than amount of sedentary time per se. Given our findings, increased amounts of physical activity with an emphasis on increased time in MVPA should be recommended in order to promote a favorable metabolic health profile in older women.
authors.affiliation: School of Health Sciences, Örebro University, Örebro, Sweden.
authors.forename: Andreas
authors.initials: A
authors.lastname: Nilsson
authors.affiliation: School of Health Sciences, Örebro University, Örebro, Sweden.
authors.forename: Britta
authors.initials: B
authors.lastname: Wåhlin-Larsson
authors.affiliation: School of Health Sciences, Örebro University, Örebro, Sweden.
authors.forename: Fawzi
authors.initials: F
authors.lastname: Kadi
mesh_terms: D000368:Aged; D016000:Cluster Analysis; D015444:Exercise; D005260:Female; D006801:Humans; D008659:Metabolic Diseases / Q000453:epidemiology*; D012307:Risk Factors; D057185:Sedentary Behavior