title: The Correlation of CD206, CD209, and Disease Severity in Behçet's Disease with Arthritis.
abstract: The purpose of this study was to clarify the role of pattern recognition receptors in Behçet's disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by flow cytometry, and cytokine levels, interleukin- (IL-) 18, IL-23, and IL-17A, were compared in plasma. The analysis was performed in active (n= 13) and inactive (n= 13) stages of BD patients. Rheumatoid arthritis patients (n= 19), as a disease control, and healthy control (HC) (n= 19) were enrolled. The frequencies of CD11b+ and CD32+ cells were significantly increased in active BD patients compared to HC. Disease severity score was correlated to CD11c+, CD206+, and CD209+ in whole leukocytes and CD11b+, CD11c+, CD206+, CD209+, and Dectin-1+ in granulocytes. The plasma levels of IL-17A were significantly different between HC and active BD. IL-18 showed significant difference between active and inactive BD patients. From this study, we concluded the expressions of several pattern recognition receptors were correlated to the joint symptoms of BD.
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Bunsoon
authors.identifier: 0000-0002-3439-6176
authors.initials: B
authors.lastname: Choi
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Chang-Hee
authors.initials: CH
authors.lastname: Suh
authors.affiliation: Department of Rheumatology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Hyoun-Ah
authors.initials: HA
authors.lastname: Kim
authors.affiliation: Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Hasan M
authors.identifier: 0000-0002-1090-7322
authors.initials: HM
authors.lastname: Sayeed
authors.affiliation: Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea; Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Seonghyang
authors.identifier: 0000-0002-4718-4818
authors.initials: S
authors.lastname: Sohn
mesh_terms: D000328:Adult; D001168:Arthritis / Q000097:blood*; D001528:Behcet Syndrome / Q000097:blood*; D039481:CD11b Antigen / Q000097:blood; D039521:CD11c Antigen / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D020381:Interleukin-17 / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D053759:Interleukin-23 / Q000097:blood; D037181:Lectins, C-Type / Q000097:blood*; D008297:Male; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000097:blood*; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood*; D017452:Receptors, IgG / Q000097:blood; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D039481:CD11b Antigen; D039521:CD11c Antigen; D015815:Cell Adhesion Molecules; D020381:Interleukin-17; D020382:Interleukin-18; D053759:Interleukin-23; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D017452:Receptors, IgG; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin