title: Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats.
abstract: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats.
  The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH.
  No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed.
  Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.
authors.affiliation: PhD, Full Professor, Researcher, Faculty of Pharmaceutical Sciences, Pontifícia Universidade Católica de Campinas (PUC-Campinas), Brazil. Conception of the study, interpretation of data.
authors.forename: Pedro Paulo
authors.initials: PP
authors.lastname: Barros
authors.affiliation: PhD, Full Professor, Researcher, Faculty of Pharmaceutical Sciences, PUC-Campinas, Brazil. Conception of the study, interpretation of data.
authors.forename: Gisele Mara Silva
authors.initials: GM
authors.lastname: Gonçalves
authors.affiliation: PhD, Full Professor, Researcher, Faculty of Pharmaceutical Sciences, PUC-Campinas, Brazil. Conception of the study, interpretation of data.
authors.forename: Gustavo Henrique da
authors.initials: GH
authors.lastname: Silva
authors.affiliation: Graduate student, School of Medicine, FAPIC, PUC-Campinas, Brazil. Interpretation of data.
authors.forename: Maria Clara Villaça Dias
authors.initials: MC
authors.lastname: Bastos
authors.affiliation: Graduate student, School of Medicine, FAPIC, PUC-Campinas, Brazil. Interpretation of data.
authors.forename: Loren Nogaroto
authors.initials: LN
authors.lastname: Ramos
authors.affiliation: Graduate student, School of Medicine, FAPIC, PUC-Campinas, Brazil. Interpretation of data.
authors.forename: Marilia Marinello
authors.initials: MM
authors.lastname: Fernandes
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001219:Aspartate Aminotransferases / Q000097:blood; D002338:Carotenoids / Q000494:pharmacology*; D006498:Hepatectomy / Q000379:methods*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology / Q000601:surgery*; D008115:Liver Regeneration / Q000187:drug effects; D000077276:Lycopene; D008297:Male; D008940:Mitotic Index; D018384:Oxidative Stress / Q000187:drug effects; D017208:Rats, Wistar; D015203:Reproducibility of Results; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D002338:Carotenoids; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000077185:Resveratrol; D000077276:Lycopene