title: Prevalence and risk factors of hyperuricemia: results of the Kailuan cohort study.
abstract: OBJECTIVE
  The objective of this study is to determine the serum uric acid (SUA) level and the prevalence of hyperuricemia (HUA) in Chinese population.
  
  
  METHODS
  We conducted a cross-sectional study among 100,226 employees (79.9% male) of the Kailuan Group using physical examination data in 2006-2007. HUA was defined as SUA >356.9 μmol/L (6.0 mg/dL) for women and SUA >416.4 μmol/L (7.0 mg/dL) for men. We investigated crude and age adjusted HUA prevalence and compared characteristics of subjects with and without HUA in men and women using multivariate logistic regression.
  
  
  RESULTS
  SUA levels were 244.9 ± 71.5 μmol/L in women and 302.0 ± 83.5 μmol/L in men. About 8290 (8.27%) subjects were diagnosed with HUA. Age-adjusted prevalence of HUA was 8.02% in the total sample (6.87% in women and 8.57% in men). The SUA level and HUA prevalence showed U-shaped or J-shaped associations with age. Multivariate logistic regression revealed age, waist circumference, total cholesterol, triglyceride, hypertension and non-alcoholic fatty liver disease history, prolonged sitting, alcohol consumption, and oral diuretics were independent risk factors of HUA, while long sleep duration was protective against HUA.
  
  
  CONCLUSIONS
  The prevalence of HUA is 6.87% and 8.57% in Chinese women and men. HUA is likely related with life style and metabolic disorders.
authors.affiliation: a Department of Rheumatology and Immunology , Kailuan General Hospital , Tangshan , Hebei Province , China.
authors.forename: Liufu
authors.initials: L
authors.lastname: Cui
authors.affiliation: b Key Laboratory of Neurological and Biological Function of Hebei Province, Kailuan General Hospital , Tangshan , Hebei Province , China.
authors.forename: Lingmin
authors.initials: L
authors.lastname: Meng
authors.affiliation: c Department of Rheumatology and Immunology , Peking University People's Hospital , Beijing , China.
authors.forename: Guanying
authors.initials: G
authors.lastname: Wang
authors.affiliation: d Department of Neurology , Kailuan General Hospital , Tangshan , Hebei Province , China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Yuan
authors.affiliation: c Department of Rheumatology and Immunology , Peking University People's Hospital , Beijing , China.
authors.forename: Zhanguo
authors.initials: Z
authors.lastname: Li
authors.affiliation: c Department of Rheumatology and Immunology , Peking University People's Hospital , Beijing , China.
authors.forename: Rong
authors.initials: R
authors.lastname: Mu
authors.affiliation: e Department of Cardiology , Kailuan General Hospital , Tangshan , Hebei Province , China.
authors.forename: Shouling
authors.initials: S
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000453:epidemiology*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011187:Posture; D015995:Prevalence; D012307:Risk Factors; D012890:Sleep; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid
keywords: Serum uric acid; cross-sectional study; hyperuricemia; influencing factor