title: Low-Dose Cyclosporine A in the Treatment of Severe Atopic Dermatitis Complicated by Chronic Hepatitis C Virus Infection.
abstract: Atopic dermatitis (AD) is the most frequent chronic inflammatory skin disorder in children and is usually accompanied by genetic and environmental factors. Effective management and treatment of AD is challenging and often requires systemic immunosuppressive therapy when refractory to topical treatments. We report a rare association between chronic hepatitis C virus (HCV) and severe AD, management of which required systemic cyclosporine because of its favorable effects on inflammatory and viral-related clinical outcomes.
authors.affiliation: Department of Dermatology, Columbia University Medical Center, New York.
authors.forename: Maria
authors.identifier: http://orcid.org/0000-0002-3872-1415
authors.initials: M
authors.lastname: Gnarra
authors.affiliation: Institute of Dermatology, Policlinico A. Gemelli, Catholic University, Rome, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: De Simone
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Policlinico A. Gemelli, Catholic University, Rome, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Garcovich
authors.affiliation: Institute of Dermatology, Policlinico A. Gemelli, Catholic University, Rome, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Garcovich
mesh_terms: D000293:Adolescent; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus