title: Erythropoiesis with endurance training: dynamics and mechanisms.
abstract: The purpose of the present study was to characterize the progression of red blood cell volume (RBCV) expansion and potential volumetric and endocrine regulators of erythropoiesis during endurance training (ET). Nine healthy, untrained volunteers (age = 27 ± 4 yr) underwent supervised ET consisting of 3-4 × 60 min cycle ergometry sessions per week for 8 wk. Plasma volume (PV), RBCV, and overnight fasting hematological markers were determined before and atweeks 2,4, and8of ET. In addition, plasma erythropoietin (EPO), cortisol, copeptin, and proatrial natriuretic peptide concentrations were measured during a 3-h morning period at baseline and postexercise atweeks 1and8PV increased from baseline (2,405 ± 335 ml) atweeks 2,4, and8(+374 ± 194, +505 ± 156, and +341 ± 160 ml, respectively,P< 0.001). Increases in RBCV from baseline (1,737 ± 442 ml) were manifested atweek 4(+109 ± 114 ml,P= 0.030) andweek 8(+205 ± 109 ml,P= 0.001). Overnight fasting plasma EPO concentration increased from baseline (11.3 ± 4.8 mIU/ml) atweek 2(+2.5 ± 2.8 mIU·ml-1,P= 0.027) and returned to baseline concentration atweeks 4and8Higher 3-h-postexercise EPO concentration was observed atweek 1(11.6 mIU/ml) compared withweek 8(8.4 ± 3.9 mIU/ml,P= 0.009) and baseline (9.0 ± 4.2 mIU/ml,P= 0.019). Linear relationships between EPO concentration and hematocrit (β = -56.2,P< 0.001) and cortisol (β = 0.037,P< 0.001) were detected throughout the ET intervention. In conclusion, ET leads to mild, transient increases in circulating EPO concentration, concurring with early PV expansion and lowered hematocrit, preceding gradual RBCV enhancement.
authors.affiliation: Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland.|Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: David
authors.initials: D
authors.lastname: Montero
authors.affiliation: Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland.|Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen, Denmark; and.
authors.forename: Andreas
authors.initials: A
authors.lastname: Breenfeldt-Andersen
authors.affiliation: Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Oberholzer
authors.affiliation: Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Haider
authors.affiliation: Department of Clinical Biochemistry, Copenhagen, and Aarhus University, Aarhus, Denmark.
authors.forename: Jens P
authors.initials: JP
authors.lastname: Goetze
authors.affiliation: Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland.
authors.forename: Anne-Kristine
authors.initials: AK
authors.lastname: Meinild-Lundby
authors.affiliation: Zurich Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland; carsten.lundby@regionh.dk.
authors.forename: Carsten
authors.initials: C
authors.lastname: Lundby
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood; D001642:Bicycling; D001823:Body Composition; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000378:metabolism / Q000502:physiology*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance; D005260:Female; D006020:Glycopeptides / Q000097:blood; D006400:Hematocrit; D006439:Hemodynamics; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010807:Physical Endurance; D010953:Plasma Volume; D013997:Time Factors; D055815:Young Adult
chemical_list: C554270:EPO protein, human; D006020:Glycopeptides; C048197:copeptins; D004921:Erythropoietin; D009320:Atrial Natriuretic Factor; D006854:Hydrocortisone
keywords: erythropoietin; exercise training; plasma volume; red blood cell volume