title: Microcephaly Case Fatality Rate Associated with Zika Virus Infection in Brazil: Current Estimates.
abstract: Considering the currently confirmed cases of microcephaly and related deaths associated with Zika virus in Brazil, the estimated case fatality rate is 8.3% (95% confidence interval: 7.2-9.6). However, a third of the reported cases remain under investigation. If the confirmation rates of cases and deaths are the same in the future, the estimated case fatality rate will be as high as 10.5% (95% confidence interval: 9.5-11.7).
authors.affiliation: From the *Departamento de Pediatria da Faculdade de Medicina da Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Puericultura e Pediatria Martagão Gesteira (IPPMG), Rio de Janeiro, Brazil; †Departamento de Pediatria, Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil; and ‡Departamento de Medicina Preventiva, Instituto de Estudos em Saúde Coletiva (IESC) da Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
authors.forename: Antonio José Ledo Alves da
authors.initials: AJ
authors.lastname: Cunha
authors.forename: Maria Clara
authors.initials: MC
authors.lastname: de Magalhães-Barbosa
authors.forename: Fernanda
authors.initials: F
authors.lastname: Lima-Setta
authors.forename: Roberto de Andrade
authors.initials: RA
authors.lastname: Medronho
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Prata-Barbosa
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D005333:Fetus; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008831:Microcephaly / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000821:virology; D054238:Perinatal Mortality / Q000639:trends*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000821:virology; D016019:Survival Analysis; D000071244:Zika Virus / Q000472:pathogenicity / Q000502:physiology; D000071243:Zika Virus Infection / Q000150:complications / Q000453:epidemiology* / Q000401:mortality / Q000821:virology