title: Efficacy of a new spot-on formulation of selamectin plus sarolaner against Ancylostoma tubaeforme and Toxocara cati in cats.
abstract: The efficacy of a new spot-on formulation of selamectin plus sarolaner for cats was evaluated against induced infections with Ancylostoma tubaeforme (hookworm) and Toxocara cati (roundworm). Five laboratory studies were conducted using adult, purpose-bred cats. Four of the studies were designed to evaluate efficacy of the combination against A. tubaeforme, the dose-limiting gastrointestinal nematode species for selamectin. In two of these studies non-interference between selamectin and sarolaner was also evaluated. The fifth study evaluated efficacy of the combination against mixed infections of A. tubaeforme and T. cati. The hookworm isolates in three studies were of US origin, as was the roundworm isolate. In the two remaining studies, cats were inoculated with a hookworm isolate of European origin. Cats were inoculated with 150 (±50) to 200 (±50) infective hookworm larvae 30-42days prior to treatment and with 400 infective roundworm eggs 60days prior to treatment. Cats were ranked by pre-treatment faecal egg counts and randomly allocated to different treatment groups. In all studies, cats were treated at the minimum label dose to provide 6.0mg selamectin per kg bodyweight. All animals were euthanized 7-10days after treatment for worm counts. Efficacy was calculated based on the reduction of the geometric mean worm counts in the treated groups versus the placebo-treated control groups. The efficacy against adult hookworms was 99.2%, 94.3% and 100% in three of these studies, and was lower in the remaining two studies. The efficacy against T. cati was 100%. Furthermore, non-interference between sarolaner and selamectin was demonstrated. Thus, a single topical application of the new spot-on formulation of selamectin plus sarolaner at the minimum label dose is effective in the treatment of adult hookworm and roundworm infections in cats.
authors.affiliation: Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, B-1930 Zaventem, Belgium. Electronic address: thomas.geurden@zoetis.com.
authors.forename: Thomas
authors.initials: T
authors.lastname: Geurden
authors.affiliation: Zoetis, Veterinary Medicine Research and Development, 333 Portage Street Kalamazoo, MI 49007, USA.
authors.forename: Adriano F
authors.initials: AF
authors.lastname: Vatta
authors.affiliation: Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, B-1930 Zaventem, Belgium.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Slootmans
authors.affiliation: Zoetis, Veterinary Medicine Research and Development, 333 Portage Street Kalamazoo, MI 49007, USA.
authors.forename: Vickie L
authors.initials: VL
authors.lastname: King
authors.affiliation: Zoetis, Veterinary Medicine Research and Development, Mercuriusstraat 20, B-1930 Zaventem, Belgium.
authors.forename: Dan
authors.initials: D
authors.lastname: Lin
authors.affiliation: Zoetis, Veterinary Medicine Research and Development, 333 Portage Street Kalamazoo, MI 49007, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: McTier
authors.affiliation: Zoetis, Veterinary Medicine Research and Development, 333 Portage Street Kalamazoo, MI 49007, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Rugg
mesh_terms: D000722:Ancylostoma; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D005260:Female; D007555:Isoxazoles / Q000008:administration & dosage*; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D011897:Random Allocation; D014119:Toxocara; D014120:Toxocariasis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000977:Antiparasitic Agents; D007555:Isoxazoles; D007559:Ivermectin; C414354:selamectin
keywords: Ancylostoma tubaeforme; Cat; Isoxazoline; Sarolaner; Selamectin; Topical Toxocara cati