title: Extracorporeal shock wave lithotripsy is safe and effective for pediatric patients with chronic pancreatitis.
abstract: Background and aimsPancreatic extracorporeal shock wave lithotripsy (P-ESWL) is recommended as the first-line treatment for pancreatic stones. However, how well P-ESWL performs in pediatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for pediatric patients with chronic pancreatitis.MethodsThis prospective observational study was conducted in patients with painful chronic pancreatitis who underwent P-ESWL. Patients aged under 18 years were included in the pediatric group; patients aged over 18 years who underwent P-ESWL in the same period were assigned to the control group. For investigation of long-term follow-up, the pediatric group were matched with patients from the control group in a 1:1 ratio. The primary outcomes were P-ESWL complications and pain relief. The secondary outcomes included: stone clearance, physical and mental health, quality of life score, and growth and developmental state.ResultsFrom March 2011 to March 2015, P-ESWL was performed in 1135 patients (72 in the pediatric group, 1063 in the control group). No significant differences were observed in the occurrence of P-ESWL complications between the two groups (11.1 % vs. 12.8 %;P= 0.68). Among the 67 pediatric patients (93.1 %) who underwent follow-up for 3.0 years (range 1.3 - 5.2), complete pain relief was achieved in 52 patients (52 /67; 77.6 %); this value was not significantly different from that of the matched controls (55 /69; 79.7 %;P= 0.94).ConclusionsP-ESWL is safe and effective for pediatric patients with chronic pancreatitis. It can promote significant pain relief and stone clearance, and can benefit growth and development.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Ya-Wei
authors.initials: YW
authors.lastname: Bi
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Ji
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xin
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Pan
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Zhuan
authors.initials: Z
authors.lastname: Liao
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Du
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Jin-Huan
authors.initials: JH
authors.lastname: Lin
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Xiang-Peng
authors.initials: XP
authors.lastname: Zeng
authors.affiliation: Department of Surgery, Jinling Hospital, Nanjing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Ye
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Zou
authors.affiliation: Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Zhongda Hospital, Southeast University, Nanjing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xie
authors.affiliation: Department of Gastroenterology, Air Force General Hospital, Beijing, China.
authors.forename: Bai-Rong
authors.initials: BR
authors.lastname: Li
authors.affiliation: Department of Traditional Chinese Medicine, Jiangdu Hospital, Yangzhou, China.
authors.forename: Zhao-Hong
authors.initials: ZH
authors.lastname: Zheng
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Zhao-Shen
authors.initials: ZS
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
authors.forename: Liang-Hao
authors.initials: LH
authors.lastname: Hu
mesh_terms: D015746:Abdominal Pain / Q000209:etiology / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D020347:Lithiasis / Q000150:complications / Q000628:therapy*; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010147:Pain Measurement; D050500:Pancreatitis, Chronic / Q000209:etiology / Q000628:therapy*; D011446:Prospective Studies; D011788:Quality of Life; D055815:Young Adult