title: Intracranial self-stimulation-reward induces neurite extension in PC12m3 cells and activation of the p38 MAPK pathway.
abstract: Factors that trigger emotional expression may be divided into two patterns according to the type of motivation, acquiring reward (pleasure) and avoiding aversion (punishment). Repeated exposure to certain external stimuli accompanied by aberrant motivation may produce psychiatric diseases such as bipolar disorder and addiction via dysregulation of the central nervous system. However, neurobiological underpinnings of such diseases have not been clarified, especially at the neuronal level. In the present study, plasma from rats undergoing intracranial self-stimulation (ICSS) produced neurite outgrowth in PC12-variant cells (PC12m3). Stimulated PC12m3 cells also exhibited heightened activity of the p38 MAPK pathway. These findings indicate that reward states lead to not only morphological changes but also increases in p38 MAPK activity at the neuronal level in the central nervous system.
authors.affiliation: Department of Pharmacy, Okayama University Hospital Pharmacy, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. Electronic address: ygomita@gmail.com.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Gomita
authors.affiliation: Department of Pharmacy, Okayama University Hospital Pharmacy, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Esumi
authors.affiliation: Department of Pharmacy, Okayama University Hospital Pharmacy, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Sugiyama
authors.affiliation: Department of Pharmacy, Okayama University Hospital Pharmacy, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
authors.affiliation: Department of Occupational Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, 1-1 Gakuenmachi, Mihara City, Hiroshima 722-0053, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Koike
authors.affiliation: Department Occupational Therapy, School of Health of Science, Kibi, International University, 8 Iga-machi Takahashi City, Okayama 716-8508, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Motoda
authors.affiliation: Department of Pharmacy, Okayama University Hospital Pharmacy, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sendo
authors.affiliation: Department Occupational Therapy, School of Health of Science, Kibi, International University, 8 Iga-machi Takahashi City, Okayama 716-8508, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kano
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology*; D016501:Neurites / Q000378:metabolism / Q000502:physiology*; D016716:PC12 Cells; D051381:Rats; D017208:Rats, Wistar; D012201:Reward; D012653:Self Stimulation; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D048051:p38 Mitogen-Activated Protein Kinases
keywords: Emotionality; Intracranial self-stimulation reward; Motivation; PC12-variant cells; p38 MAPK pathway