title: [Over-expressions of p-eIF4E and p-4EBP1 are associated with poor prognosis in nasopharyngeal carcinoma].
abstract: Objective To observe the expressions of phosphorylated eukaryotic translation initiation factor 4E (p-eIF4E) and phospho-eIF4E-binding protein 1 (p-4EBP1) and investigate their associations with clinicopathological features and prognosis in nasopharyngeal carcinoma (NPC). Methods We detected the expressions of p-eIF4E and p-4EBP1 proteins by immunohistochemistry in NPC tissues (n=314 cases), and analyzed the associations between the expressions of p-eIF4E and p-4EBP1 proteins and clinicopathological features and prognosis in NPC by SPSS16.0. Results Positive rates of p-eIF4E and p-4EBP-1 proteins in NPC were 74.2% (233/314) and 72.9% (229/314), respectively. There were significantly higher expressions of p-eIF4E and p-4EBP-1 proteins in the cases with lymph node metastasis than in those without lymph node metastasis. However, no significant correlations were observed between the expressions of p-eIF4E and p-4EBP-1 proteins and the age, gender, histological type, and clinical stage. There was significantly positive relationship between p-eIF4E and p-4EBP1 protein expressions in NPC. The overall survival rates were higher in the NPC patients with negative expressions of p-eIF4E and p-4EBP1 proteins than in those with positive expressions. The positive expressions of p-eIF4E and p-4EBP1 proteins were identified as the independent poor prognostic factors in NPC. Conclusion The over-expression of p-eIF4E and p-4EBP-1 proteins may be closely related to the occurrence, development and adverse prognosis of NPC. Hence, p-eIF4E and p-4EBP1 proteins are expected to be molecular markers for clinical diagnosis and prognosis of NPC.
authors.affiliation: Department of Biochemistry, Changzhi Medical College, Changzhi 046000; Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Obstetrics, Heping Hospital, Changzhi Medical College, Changzhi 046000, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry, Changzhi Medical College, Changzhi 046000, China.
authors.forename: Yiqiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry, Changzhi Medical College, Changzhi 046000, China.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Pei
authors.affiliation: Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011, China. *Corresponding author, E-mail: fansonqing2003@hotmail.com.
authors.forename: Songqing
authors.initials: S
authors.lastname: Fan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018797:Cell Cycle Proteins; D039561:Eukaryotic Initiation Factor-4E / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D011379:Prognosis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; C087000:EIF4EBP1 protein, human; D039561:Eukaryotic Initiation Factor-4E; D010750:Phosphoproteins