title: Polymers as Carriers of Gentamicin in Traumatology and Orthopedic Surgery - Current State Of Knowledge.
abstract: Osteomyelitis in patients undergoing surgery because of injuries and diseases of the musculoskeletal system is a serious clinical, economic and social problem. It is one of the greatest therapeutic challenges in traumatology and orthopedic surgery. To achieve the best results in the treatment of osteomyelitis, surgical debridement and intravenous antibiotic therapy is supported by local antibiotic delivery. Many different substances can be used as drug carriers. In this study we present and compare some polymers used as carriers of gentamicin. Some of them, such as poly(methyl methacrylate), are well known and have been used for 30 years, and others, such as polycaprolactone, polyacrylic acid, polyanhydrides, poly-trimethylene carbonate, polylactide, polyglycolide and poly(trimethylene carbonate), are perspectives for the future. In this study, we have tried to briefly present all of these polymers and compare some of their features. We have concentrated on the pharmacokinetics and bioactivity of such implants, which are important aspects for their potential practical use.
authors.affiliation: University Clinical Hospital in Wroclaw, Wroclaw Medical University, Wrocław, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Witkowski
authors.affiliation: University Clinical Hospital in Wroclaw, Wroclaw Medical University, Wrocław, Poland.|Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Wrocław, Poland.
authors.forename: Witold
authors.initials: W
authors.lastname: Wnukiewicz
authors.affiliation: University Clinical Hospital in Wroclaw, Wroclaw Medical University, Wrocław, Poland.|Department of Traumatology, Clinic of Traumatology and Hand Surgery, Wroclaw Medical University, Wrocław, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Reichert
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001672:Biocompatible Materials; D004337:Drug Carriers; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D019637:Orthopedic Procedures / Q000009:adverse effects*; D010019:Osteomyelitis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D011108:Polymers; D019736:Prostheses and Implants; D014194:Traumatology
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D005839:Gentamicins; D011108:Polymers
keywords: drug carriers; gentamicin; osteomyelitis; polymers