title: [Autoimmune encephalitis induced by antibodies against GABA-A receptor].
abstract: Among autoimmune encephalitides, a prevalent group are those associated with antibodies against the N-Methyl-D-aspartate receptor, which present with behavior abnormalities, psychosis, seizures and abnormal movements. A new variant, mediated by antibodies against the GABA-A receptor, was recen-tly described. We report a 66-years-old female with this form of encephalitis whose main manifestation was the presence of severe seizures leading to status epilepticus. The patient had a good response to immunomodulatory therapy with intravenous methylprednisolone, azathioprine and anticonvulsants. The laboratory tests initially detected anti-thyroid peroxidase antibodies which lead to the misdiagnosis of Hashimoto Encephalitis, which was ruled out after the detection of antibodies against GABA-A receptor. No malignancy was detected.
authors.affiliation: Departamento Neurología, Clínica Las Condes, Santiago, Chile.
authors.forename: Pablo
authors.initials: P
authors.lastname: González R
authors.affiliation: Departamento Neurología, Clínica Las Condes, Santiago, Chile.
authors.forename: Lorena
authors.initials: L
authors.lastname: Hudson A
authors.affiliation: Departamento Neurología, Clínica Las Condes, Santiago, Chile.
authors.forename: Esteban
authors.initials: E
authors.lastname: Basáez M
authors.affiliation: Departamento Neurología, Clínica Las Condes, Santiago, Chile.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Miranda C
mesh_terms: D000368:Aged; D000906:Antibodies / Q000276:immunology; D004660:Encephalitis / Q000000981:diagnostic imaging / Q000276:immunology*; D005260:Female; D050031:Hashimoto Disease / Q000000981:diagnostic imaging / Q000276:immunology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D011963:Receptors, GABA-A / Q000276:immunology*; D012640:Seizures / Q000276:immunology
chemical_list: D000906:Antibodies; D011963:Receptors, GABA-A