title: A large giant cell tumor of the larynx: case report and review of the literature.
abstract: BACKGROUND
  Giant cell tumors (GCTs) are typically found in the metaphyseal-epiphyseal area of long bones but can also occur in the head and neck region. GCT of the larynx is a rare entity with only 42 reported cases in the international literature. Furthermore, to the best of our knowledge this is the largest laryngeal GCT reported in the literature to date. GCT of the larynx can present with dysphonia, dyspnea, and/or dysphagia and should be considered in the differential diagnosis of a neck mass.
  
  
  METHODS
  This case report describes a giant cell tumor of the left thyroid cartilage in a 30-year-old man who initially presented with dysphonia and dysphagia. Computed tomography (CT) revealed a 5 × 5.7 cm mass centered on the left thyroid cartilage, which was further diagnosed by histopathology as giant cell tumour by open biopsy. The patient was counselled on treatment options and it was decided to proceed with a surgical approach. The patient consented to and successfully underwent a total laryngectomy (TL). Currently the patient has no evidence of disease at 13 months follow-up, has an optimal prosthetic voice, and is able to tolerate all textures of foods.
  
  
  CONCLUSIONS
  GCTs of the larynx have a good prognosis and can be treated successfully through complete resection of the tumor, negating the need for adjunctive therapy such as radiation, chemo or denosumab therapy.
authors.affiliation: College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
authors.forename: Andrew
authors.initials: A
authors.lastname: Arndt
authors.affiliation: College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
authors.forename: Rachelle
authors.initials: R
authors.lastname: LeBlanc
authors.affiliation: Clinical Professor and Division Head: Otolaryngology - Head & Neck Surgery, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. p.spafford@sasktel.net.
authors.forename: Peter
authors.initials: P
authors.lastname: Spafford
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D005870:Giant Cell Tumors / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
keywords: Case report; Giant cell tumor; Larynx; Thyroid cartilage