title: Complement Components Are Expressed by Infiltrating Macrophages/Activated Microglia Early Following Viral Infection.
abstract: The individual innate immune components, interleukin-6 and complement component C3, play a role in the development of acute seizures in the Theiler's murine encephalomyelitis virus-induced seizure model. We examined the mRNA expression of various other complement components, cytokines, chemokines, and major histocompatibility complex antigens both within brain and in isolated ramified microglial and infiltrating macrophage/activated microglial cell populations over a time course covering the first 3 days postinfection. We found that complement component C3 showed the greatest increase in expression in brain of all of the complement components assayed and its level of expression was higher in infiltrating macrophages/activated microglia than in ramified microglial cells.
authors.affiliation: Department of Pathology, University of Utah School of Medicine , Salt Lake City, Utah.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Libbey
authors.affiliation: Department of Pathology, University of Utah School of Medicine , Salt Lake City, Utah.
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Cusick
authors.affiliation: Department of Pathology, University of Utah School of Medicine , Salt Lake City, Utah.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Doty
authors.affiliation: Department of Pathology, University of Utah School of Medicine , Salt Lake City, Utah.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Fujinami
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D018188:Cardiovirus Infections / Q000276:immunology*; D003176:Complement C3 / Q000096:biosynthesis*; D020869:Gene Expression Profiling; D007155:Immunologic Factors / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000276:immunology*; D017945:Theilovirus / Q000276:immunology*; D013997:Time Factors
chemical_list: D003176:Complement C3; D007155:Immunologic Factors
keywords: Theiler's murine encephalomyelitis virus; complement; innate immune response; picornavirus; seizures; viral encephalitis