title: Highly palatable food access during adolescence increased anxiety-/depression-like behaviors in male, but not in female, rats.
abstract: OBJECTIVE
  This study was conducted to examine the sexual dimorphic effects of highly palatable food (HPF) access during adolescence on the neurochemistry and depression-/anxiety-like behaviors of rats.
  
  
  METHODS
  Male and female Sprague-Dawley pups had free access to chocolate cookie rich in fat (HPF) from postnatal day 28 in addition to ad libitum chow, and the control groups received only chow. The food conditions were continued throughout the entire experimental period, and the neurochemical and behavioral measurements were performed during young adulthood. Rats were subjected to the ambulatory activity, elevated plus maze, and forced swim tests. Corticosterone levels during 2 h of restraint stress were analyzed with radioimmunoassay, and ΔFosB and brain-derived neurotrophic factor (BDNF) expression in the nucleus accumbens (NAc) with Western blot analysis.
  
  
  RESULTS
  Cookie access did not affect body weight gain and total caloric intake in both sexes; however, it increased retroperitoneal fat depot only in males. The time spent in open arms during elevated plus maze test was decreased and immobility during forced swim test was increased in cookie-fed males, but not in cookie-fed females. Main effect of food condition on the stress-induced corticosterone increase was observed in males, but not in females, and cookie access increased BDNF expression in the NAc only in males.
  
  
  CONCLUSIONS
  Increased BDNF expression in the NAc and fat depot, in addition to the stress axis dysfunction, may play roles in the pathophysiology of depression- and/or anxiety-like behaviors induced by cookie access.
authors.affiliation: a Department of Oral and Maxillofacial Surgery , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: a Department of Oral and Maxillofacial Surgery , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea.|b Department of Brain Science , Daegu Gyeongbuk Institute of Science & Technology , Dae Gu 711-873 , Korea.
authors.forename: Doyun
authors.initials: D
authors.lastname: Kim
authors.affiliation: c Department of Physiology , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea.
authors.forename: Kyungpyo
authors.initials: K
authors.lastname: Park
authors.affiliation: a Department of Oral and Maxillofacial Surgery , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea.
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Lee
authors.affiliation: a Department of Oral and Maxillofacial Surgery , Dental Research Institute, Seoul National University School of Dentistry , Seoul 110-768 , Korea.
authors.forename: Jeong Won
authors.initials: JW
authors.lastname: Jahng
mesh_terms: D000818:Animals; D001007:Anxiety / Q000097:blood* / Q000209:etiology; D001522:Behavior, Animal; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D003863:Depression / Q000097:blood* / Q000209:etiology; D004032:Diet; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D018782:Maze Learning; D009714:Nucleus Accumbens / Q000378:metabolism; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013315:Stress, Psychological / Q000097:blood / Q000150:complications; D015430:Weight Gain
chemical_list: C000628854:Bdnf protein, rat; D019208:Brain-Derived Neurotrophic Factor; D003345:Corticosterone
keywords: Corticosterone; Food intake; Nucleus accumbens; Stress