title: A review of the importance of immune responses in luminal B breast cancer.
abstract: Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative. We hypothesize that a profound immunosuppressive tumor and/or lymph node milieu is prognostic and impacts on responses to therapies.
authors.affiliation: School of Biomedical Sciences, Curtin University, Bentley, Perth, WA, Australia; CHIRI Biosciences, Curtin University, Perth, WA, Australia.
authors.forename: Delia J
authors.initials: DJ
authors.lastname: Nelson
authors.affiliation: School of Biomedical Sciences, Curtin University, Bentley, Perth, WA, Australia; CHIRI Biosciences, Curtin University, Perth, WA, Australia.
authors.forename: Briony
authors.initials: B
authors.lastname: Clark
authors.affiliation: School of Biomedical Sciences, Curtin University, Bentley, Perth, WA, Australia; CHIRI Biosciences, Curtin University, Perth, WA, Australia.
authors.forename: Kylie
authors.initials: K
authors.lastname: Munyard
authors.affiliation: School of Biomedical Sciences, Curtin University , Bentley, Perth, WA, Australia.
authors.forename: Vincent
authors.initials: V
authors.lastname: Williams
authors.affiliation: School of Biomedical Sciences, Curtin University, Bentley, Perth, WA, Australia; CHIRI Biosciences, Curtin University, Perth, WA, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Groth
authors.affiliation: Western Diagnostics Pathology , Myaree, Perth, WA, Australia.
authors.forename: Jespal
authors.initials: J
authors.lastname: Gill
authors.affiliation: Western Diagnostics Pathology , Myaree, Perth, WA, Australia.
authors.forename: Henry
authors.initials: H
authors.lastname: Preston
authors.affiliation: Breast Cancer Research Centre-WA, Hollywood Private Hospital, Nedlands, WA, Australia; Curtin Medical School, Curtin University, Perth, WA, Australia.
authors.forename: Arlene
authors.initials: A
authors.lastname: Chan
keywords: Anticancer immunity; checkpoint molecules; luminal B breast cancer; predictive; prognostic