title: [Coffee in Cancer Chemoprevention].
abstract: Coffee consumption is associated with a reduced risk of several diseases including cancer. Its chemopreventive effect has been studied in vitro, in animal models, and more recently in humans. Several modes of action have been proposed, namely, inhibition of oxidative stress and damage, activation of metabolizing liver enzymes involved in carcinogen detoxification processes, and anti-inflammatory effects. The antioxidant activity of coffee relies partly on its chlorogenic acid content and is increased during the roasting process. Maximum antioxidant activity is observed for medium-roasted coffee. The roasting process leads to the formation of several components, e.g., melanoidins, which have antioxidant and anti-inflammatory properties. Coffee also contains two specific diterpenes, cafestol and kahweol, which have anticarcinogenic properties. Roasted coffee is a complex mixture of various chemicals. Previous studies have reported that the chemopreventive components present in coffee induce apoptosis, inhibit growth and metastasis of tumor cells, and elicit antiangiogenic effects. A meta-analysis of epidemiological studies showed that coffee consumption is associated with a lower risk of developing various malignant tumors. This review summarizes the molecular mechanisms and the experimental and epidemiological evidence supporting the chemopreventive effect of coffee.Key words: coffee - chemoprevention - antioxidative enzyme - detoxification enzyme - anti-inflammatory effect The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Submitted: 11. 9. 2016Accepted: 24. 11. 2016.
authors.forename: J
authors.initials: J
authors.lastname: Neuwirthová
authors.forename: B
authors.initials: B
authors.lastname: Gál
authors.forename: P
authors.initials: P
authors.lastname: Smilek
authors.forename: P
authors.initials: P
authors.lastname: Urbánková
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D018890:Chemoprevention / Q000379:methods; D003069:Coffee; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology*
chemical_list: D000975:Antioxidants; D003069:Coffee