title: AIDing-targeted protein degradation in Drosophila.
abstract: Conditional protein depletion is highly desirable for investigating protein functions in complex organisms. In this issue, Bence and colleagues combined auxin-inducible degradation with CRISPR, establishing an elegant tool to control protein levels. They achieve precise spatio-temporal control of protein degradation during Drosophila oogenesis and early embryogenesis by combining suitable GAL4 drivers (spatial control) with auxin feeding protocols (temporal control).
authors.affiliation: Muscle Dynamics Group, Max Planck Institute of Biochemistry, Martinsried, Germany.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Muscle Dynamics Group, Max Planck Institute of Biochemistry, Martinsried, Germany.|Developmental Biology Institute of Marseille (IBDM), CNRS, UMR 7288, Aix-Marseille Université, France.
authors.forename: Frank
authors.initials: F
authors.lastname: Schnorrer
mesh_terms: D000818:Animals; D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D004330:Drosophila / Q000196:embryology / Q000378:metabolism*; D047108:Embryonic Development; D007210:Indoleacetic Acids / Q000378:metabolism*; D009866:Oogenesis; D011506:Proteins / Q000378:metabolism*
chemical_list: D007210:Indoleacetic Acids; D011506:Proteins