title: Correlations Between MMPs and TIMPs Levels in Aqueous Humor from High Myopia and Cataract Patients.
abstract: To study the relationships between matrix metalloproteinases (MMP)-2, MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMP)-1, TIMP-2, and TIMP-3 aqueous humor levels in patients with high myopia or cataract.
  
  
  
  MMPs and TIMPs protein levels in 65 aqueous humor samples collected from patients with high myopia or cataract during cataract or clear lens extraction surgery were measured with the Luminex xMAP Technology. The relationship between MMPs and TIMPs levels was analyzed with Spearman's correlation test.
  
  
  
  MMP-2 levels, but not MMP-3 levels, were increased in the aqueous humor from high-myopia patients. Levels of TIMP-1, -2, and -3 were positively and very significantly correlated with the MMP-2 levels (TIMP-1: r=0.626, p < 0.001; TIMP-2: r = 0.545, p < 0.001; TIMP-3: r = 0.439, p < 0.001). TIMP-2 and-3 levels did not significantly correlate with MMP-3 levels (TIMP-2: r = 0.175, p > 0.05; TIMP-3: r = 0.127, p > 0.05) and TIMP-1 levels only marginally correlated with MMP-3 levels (r = 0.278, 0.01< P < 0.05).
  
  
  
  Compared to the present findings with the relationship of MMPs and TIMPs in other fields of medicine, our results are consistent with the homeostasis hypothesis that the increase of TIMPs serves as a compensation reaction to inhibit the excessive degradation caused by the increase of MMPs and limits the development of myopia.
authors.affiliation: a Department of Ophthalmology , Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine , Shanghai , P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jia
authors.affiliation: b Departments of Ophthalmology and Pathology , New York Eye and Ear Infirmary of Mount Sinai , New York , NY USA.
authors.forename: Dan-Ning
authors.initials: DN
authors.lastname: Hu
authors.affiliation: a Department of Ophthalmology , Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine , Shanghai , P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: a Department of Ophthalmology , Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine , Shanghai , P. R. China.
authors.forename: Jibo
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000328:Adult; D001082:Aqueous Humor / Q000201:enzymology*; D058452:Axial Length, Eye / Q000473:pathology; D002386:Cataract / Q000201:enzymology*; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D008875:Middle Aged; D047728:Myopia, Degenerative / Q000201:enzymology*; D013223:Statistics as Topic; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism; D019717:Tissue Inhibitor of Metalloproteinase-3 / Q000378:metabolism; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*
chemical_list: C560822:TIMP1 protein, human; C560823:TIMP2 protein, human; C088390:TIMP3 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D019717:Tissue Inhibitor of Metalloproteinase-3; D019714:Tissue Inhibitor of Metalloproteinases; D019716:Tissue Inhibitor of Metalloproteinase-2; D020782:Matrix Metalloproteinases; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
keywords: Aqueous humor; MMPs; TIMPs; correlation study; myopia