title: Assessing Initial Response to High-Frequency Jet Ventilation in Premature Infants With Hypercapnic Respiratory Failure.
abstract: BACKGROUND
  High-frequency jet ventilation (HFJV) has been used in conjunction with conventional ventilation for infants with respiratory failure. We sought to identify parameters that were associated with successful application of HFJV in patients with hypercapnic respiratory failure.
  
  
  METHODS
  A single-center, retrospective review of infants who received HFJV was conducted. Subjects were enrolled if birthweight was ≤2,000 g and capillary PCO2was ≥55 mm Hg. Ventilator parameters and physiologic data were recorded at 1 h before HFJV initiation and at hours 1, 4, and 6 following conversion. Subjects were classified as responders if capillary PCO2was reduced by ≥10% after 1 h of HFJV. Data included peak inspiratory pressure, PEEP, capillary PCO2, and oxygen saturation index (equal to mean airway pressure × FIO2× 100/SpO2). Because the data were not normally distributed, they are reported as median (interquartile range), and the Mann-Whitney test was used to assess differences in continuous data between groups. Categorical data were analyzed using a chi-square and Fisher exact test.
  
  
  RESULTS
  Thirty-four premature infants (n= 24 male) were studied. Twenty-five subjects were classified as responders and demonstrated a significant reduction of capillary PCO2and FIO2and increased pH within the first hour. The non-responders demonstrated a higher conventional ventilation peak inspiratory pressure (25 cm H2O vs 19 cm H2O,P= .005) and had a greater postmenstrual age (30 weeks vs 26.5 weeks,P= .01). This group had a higher oxygen saturation index (7.25 vs 3.36,P= .03) and FIO2requirements (0.6 vs 0.35,P= .038) at 4 h.
  
  
  CONCLUSIONS
  We identified that lower postmenstrual age, improvements in capillary PCO2and pH at 1 h, and a reduction of FIO2were associated with good response to HFJV. These data may help to identify patients who are likely to benefit from HFJV in the neonatal intensive care unit.
authors.affiliation: Department of Respiratory Care, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Craig R
authors.initials: CR
authors.lastname: Wheeler
authors.affiliation: Department of Respiratory Care, Boston Children's Hospital, Boston, Massachusetts.|Division of Critical Care Medicine, Department of Anesthesia, Preoperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Craig D
authors.initials: CD
authors.lastname: Smallwood
authors.affiliation: Department of Respiratory Care, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Iris
authors.initials: I
authors.lastname: O'Donnell
authors.affiliation: Department of Respiratory Care, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gagner
authors.affiliation: Division of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Martha C
authors.initials: MC
authors.lastname: Sola-Visner
mesh_terms: D002245:Carbon Dioxide / Q000032:analysis; D005260:Female; D005865:Gestational Age; D006611:High-Frequency Jet Ventilation / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D012123:Pulmonary Ventilation / Q000502:physiology; D012121:Respiration, Artificial / Q000379:methods*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide
keywords: chronic lung disease; high-frequency jet ventilation; high-frequency oscillatory ventilation; mechanical ventilation; prematurity; respiratory distress syndrome