title: Efficacy of Intravenous Administration of Landiolol in Patients With Acute Heart Failure and Supraventricular Tachyarrhythmia.
abstract: BACKGROUND
  Patients with acute heart failure (HF) complicated by supraventricular tachyarrhythmia (SVT) often receive continuous intravenous infusion of landiolol or diltiazem for rate control. It is unclear whether the interval from initiation of infusion to commencement of oral beta-blocker (BB) therapy differs for these two drugs.
  
  
  METHODS
  From January 2013 to July 2015, 94 consecutive patients were hospitalized for acute HF complicated by SVT. After 35 patients were excluded, the remaining 59 were divided into groups treated with diltiazem or landiolol. We investigated the blood pressure, heart rate, New York Heart Association classification, brain natriuretic peptide, chest X-ray film, echocardiographic findings (ejection fraction (EF)), time until commencement of oral BB therapy, and hospital stay.
  
  
  RESULTS
  There were no significant between-group differences of heart rate, blood pressure, or the severity of HF. The time until commencing oral BB therapy was significantly shorter in the landiolol group compared with the diltiazem group (median: 2 vs. 4 days, P = 0.002), but there was no significant difference in hospital stay. This interval was significantly shorter in patients with a reduced EF in the landiolol group (median: 2 days) compared with those with a reduced EF in the diltiazem group (median: 5 days, P = 0.008), and patients with a preserved EF in the landiolol group tended to have a shorter interval (median: 2 days) than those with a preserved EF in the diltiazem group (median: 4 days, P = 0.092).
  
  
  CONCLUSIONS
  Switching to oral BBs was accomplished earlier with landiolol than with diltiazem.
authors.affiliation: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kiuchi
authors.affiliation: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Aikawa
authors.affiliation: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Hisatake
authors.affiliation: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kabuki
authors.affiliation: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Oka
authors.affiliation: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Dobashi
authors.affiliation: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujii
authors.affiliation: Department of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Ikeda
keywords: Beta-blocker; Blood pressure; Calcium channel blocker; Heart rate; Hospital stay