title: Synthesis of Chrysogeside B from Halotolerant Fungus Penicillium and Its Antimicrobial Activities Evaluation.
abstract: Chrysogeside B, a natural cerebroside, was efficiently synthesized from commercial feedstocks. The bioassays showed that compounds 4, 5 and 6 exhibited enhanced biological activities compared Chrysogeside B. Further studies revealed that free hydroxyl groups and glycosidic bond have significant impact on the antimicrobial activities. The synthesis of Chrysogeside B and analogues designed to allow identification of the features of this glycolipid required for recognition by tested bacteria and Hela cells is described.
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Ruiquan
authors.initials: R
authors.lastname: Liu
authors.affiliation: Nutrichem Company Limited, No. 27 Life Sciences Park Road, Changping District, Beijing 102206, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Qibo
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Liao
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.affiliation: China Crop Protection Industry Association, Anhuili Siqu Building 16#, Chaoyang District, Beijing 100723, P.R. China.
authors.forename: Cong
authors.initials: C
authors.lastname: Lv
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Zheng
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Jiangchun
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Bian
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Applied Chemistry, China Agricultural University, No. 2 West Yuanmingyuan Road, Beijing 100193, P.R. China.
authors.forename: Shangzhong
authors.initials: S
authors.lastname: Liu
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002554:Cerebrosides / Q000138:chemical synthesis / Q000737:chemistry*; D021902:Enterobacter aerogenes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D002554:Cerebrosides