title: Factors Influencing the Gross Motor Outcome of Intensive Therapy in Children with Cerebral Palsy and Developmental Delay.
abstract: The study was designed to identify factors influencing the short term effect of intensive therapy on gross motor function in children with cerebral palsy or developmental delay. Retrospectively, total Gross Motor Function Measure-88 (GMFM-88) scores measured during the first and last weeks of intensive therapy were analyzed (n = 103). Good and poor responder groups were defined as those in the top and bottom 25% in terms of score difference, respectively. The GMFM-88 score increased to 4.67 ± 3.93 after 8 weeks of intensive therapy (P < 0.001). Gross Motor Function Classification System (GMFCS) level (I-II vs. IV-V; odds ratio [OR] = 7.763, 95% confidence interval [CI] = 2.177-27.682, P = 0.002) was a significant factor in a good response to therapy. Age (≥ 36 months; OR = 2.737, 95% CI = 1.003-7.471, P = 0.049) and GMFCS level (I-II vs. IV-V; OR = 0.189, 95% CI = 0.057-0.630, P = 0.007; and III vs. IV-V; OR = 0.095, 95% CI = 0.011-0.785, P = 0.029) were significantly associated with a poor response. GMFCS level is the most important prognostic factor for the effect of intensive therapy on gross motor function. In addition, age ≥ 36 months, is associated with a poor outcome.
authors.affiliation: Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea. byhong@catholic.ac.kr.
authors.forename: Bo Young
authors.identifier: http://orcid.org/0000-0001-9290-6173
authors.initials: BY
authors.lastname: Hong
authors.affiliation: Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Leechan
authors.identifier: http://orcid.org/0000-0001-7375-3626
authors.initials: L
authors.lastname: Jo
authors.affiliation: Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Joon Sung
authors.identifier: http://orcid.org/0000-0001-7457-593X
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Seong Hoon
authors.identifier: http://orcid.org/0000-0002-5475-4153
authors.initials: SH
authors.lastname: Lim
authors.affiliation: Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
authors.forename: Jung Min
authors.identifier: http://orcid.org/0000-0001-5975-8519
authors.initials: JM
authors.lastname: Bae
mesh_terms: D002547:Cerebral Palsy / Q000503:physiopathology / Q000534:rehabilitation / Q000628:therapy*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000503:physiopathology / Q000534:rehabilitation / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis; D012720:Severity of Illness Index
keywords: Cerebral Palsy; Developmental Disabilities; Early Intervention; Rehabilitation