title: Comparison of two prognostic scores (BSI and FACED) in a Spanish cohort of adult patients with bronchiectasis and improvement of the FACED predictive capacity for exacerbations.
abstract: Bronchiectasis (BE) is a chronic and heterogeneous respiratory disease that requires a multidimensional scoring system to properly assess severity. The aim of this study was to compare the severity stratification by 2 validated scores (BSI and FACED) in a BE cohort and to determine their predictive capacity for exacerbations and hospitalizations. Moreover, we proposed a modified version of FACED which was created to better predict the risk of exacerbations in clinical practice. We performed a prospective cohort study including BE patients >18 years old with a follow-up period of 1-year. One-hundred eighty-two patients (40% males; mean age 68) were studied. Patients were stratified according to the number of exacerbations during the follow-up, and according to BSI and FACED scores. BSI classified most of our patients as severe 99 (54.4%) or moderate 47 (25.8%), while FACED mainly classified as mild 108 (59.3%) or moderate 61 (33.5%). BSI and FACED showed an area under ROC curve (AUC) for exacerbations of 0.808 and 0.734; and for hospitalizations (due to BE exacerbations) of 0.893 and 0.809, respectively. Subsequently, we modified FACED by adding previous exacerbations (Exa-FACED) and this new score classified patients as mild 48.4%, moderate 34.6% and severe 17.0%, with an improved AUC for exacerbations (0.760) and hospitalizations (0.820). Despite previous validations of BSI and FACED, they classified our patients very differently. As expected, FACED showed poor prognostic capacity for exacerbations. We support the Exa-FACED score to predict the risk future exacerbations for been easy to use in clinical practice.
authors.affiliation: Fundació Clínic, IDIBAPS, CIBERES, Servicio de Neumología, Hospital Clinic de Barcelona, Barcelona, España.
authors.forename: Edmundo
authors.initials: E
authors.lastname: Rosales-Mayor
authors.affiliation: Fundació Clínic, IDIBAPS, CIBERES, Servicio de Neumología, Hospital Clinic de Barcelona, Barcelona, España.
authors.forename: Eva
authors.initials: E
authors.lastname: Polverino
authors.affiliation: Facultad de Medicina, Universidad de Barcelona, Barcelona, España.
authors.forename: Laura
authors.initials: L
authors.lastname: Raguer
authors.affiliation: Fundació Clínic, IDIBAPS, CIBERES, Servicio de Neumología, Hospital Clinic de Barcelona, Barcelona, España.
authors.forename: Victoria
authors.initials: V
authors.lastname: Alcaraz
authors.affiliation: Fundació Clínic, IDIBAPS, CIBERES, Servicio de Neumología, Hospital Clinic de Barcelona, Barcelona, España.
authors.forename: Albert
authors.initials: A
authors.lastname: Gabarrus
authors.affiliation: Fundació Clínic, IDIBAPS, CIBERES, Servicio de Neumología, Hospital Clinic de Barcelona, Barcelona, España.
authors.forename: Otavio
authors.initials: O
authors.lastname: Ranzani
authors.affiliation: CIBERES, Instituto de Investigación Sanitaria La Fe, Servicio de Neumología, Hospital Universitario y Politécnico La Fe de Valencia, Valencia, España.
authors.forename: Rosario
authors.initials: R
authors.lastname: Menendez
authors.affiliation: Fundació Clínic, IDIBAPS, CIBERES, Servicio de Neumología, Hospital Clinic de Barcelona, Barcelona, España.
authors.forename: Antoni
authors.identifier: http://orcid.org/0000-0002-5649-7699
authors.initials: A
authors.lastname: Torres
mesh_terms: D000368:Aged; D001987:Bronchiectasis / Q000473:pathology* / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013030:Spain