title: A Foldamer-Based Organocatalyst for Direct Arylations of Unactivated Arenes.
abstract: It was demonstrated that a simple yet well-folded pyridone dimer, possessing two convergently aligned electron-rich O atoms for potassium binding, can serve as a highly efficient organocatalyst for catalyzing transition-metal-free arylations of unactivated aromatic C-H bonds with aryl halides in the presence of t-BuOK. A wide range of aryl iodides could be cross-coupled with unactivated arenes in moderate to excellent yields. The experiments using radical-scavenging reagents confirm the participation of radicals in this catalytic transformation.
authors.affiliation: School of Chemistry and Chemical Engineering, University of Jinan , Jinan, Shandong, 255022, China.
authors.forename: Huaiqing
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Institute of Bioengineering and Nanotechnology , 31 Biopolis Way, The Nanos, 138669, Singapore.
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.affiliation: Institute of Bioengineering and Nanotechnology , 31 Biopolis Way, The Nanos, 138669, Singapore.
authors.forename: Changliang
authors.initials: C
authors.lastname: Ren
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, 510641, China.
authors.forename: Wei
authors.identifier: 0000-0002-6113-2459
authors.initials: W
authors.lastname: Zeng
authors.affiliation: Institute of Bioengineering and Nanotechnology , 31 Biopolis Way, The Nanos, 138669, Singapore.
authors.forename: Huaqiang
authors.identifier: 0000-0002-8246-2000
authors.initials: H
authors.lastname: Zeng