title: Guaiane-Type Sesquiterpenoids from Alismatis Rhizoma and Their Anti-inflammatory Activity.
abstract: Twelve guaiane-type sesquiterpenoids, including four new ones, 10-O-methyl-orientalol A (1), 10-O-ethyl-alismoxide (2), 3β,4β-expoxy-chrysothol (3), orientalol G (4), and a new norsesquiterpenoid, orientalol H (5), were isolated from Chinese Alismatis Rhizoma, the dried rhizome of Alisma orientale. The structures of new compounds were elucidated on the basis of spectroscopic data. Moreover, the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells of all compounds was tested.
authors.affiliation: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Fan
authors.forename: Yong
authors.initials: Y
authors.lastname: Xue
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Xing-De
authors.initials: XD
authors.lastname: Wu
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism; D027343:Rhizome / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C421026:guaiane; D009569:Nitric Oxide