title: [Prenatal diagnosis of 22q11 microdeletion syndrome].
abstract: OBJECTIVE
  To establish a method for the prenatal diagnosis of 22q11 microdeletion syndrome.
  
  
  METHODS
  BACs-on-Beads (BoBs) and fluorescence in situ hybridization (FISH) were performed on a fetus for whom amniotic chromosomal culturing has failed and a pair of twin fetuses suspected for 22q11 deletion syndrome.
  
  
  RESULTS
  22q11 microdeletion was detected in all 3 fetuses by prenatal BoBs as well as FISH, with only one red signal detected at the DiGeorge/VCFS N25 site and two green signals on the 22q13.3 ARSA site.
  
  
  CONCLUSIONS
  The combination of prenatal BoBs and FISH can provide a method for the prenatal diagnosis of 22q11 microdeletion.
authors.affiliation: Fujian Hospital for Material and Child Health Care, Fuzhou, Fujian 350001, China. ipxiu304@126.com.
authors.forename: Meiying
authors.initials: M
authors.lastname: Cai
authors.forename: Hailong
authors.initials: H
authors.lastname: Huang
authors.forename: Na
authors.initials: N
authors.lastname: Lin
authors.forename: Nan
authors.initials: N
authors.lastname: Guo
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Wu
authors.forename: Linjuan
authors.initials: L
authors.lastname: Su
authors.forename: Liangpu
authors.initials: L
authors.lastname: Xu
mesh_terms: D000328:Adult; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D004062:DiGeorge Syndrome / Q000175:diagnosis / Q000196:embryology / Q000235:genetics*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis