title: CT and histopathologic characteristics of lung adenocarcinoma with pure ground-glass nodules 10 mm or less in diameter.
abstract: OBJECTIVE
  To evaluate CT and histopathologic features of lung adenocarcinoma with pure ground-glass nodule (pGGN) ≤10 mm in diameter.
  
  
  METHODS
  CT appearances of 148 patients (150 lesions) who underwent curative resection of lung adenocarcinoma with pGGN ≤10 mm (25 atypical adenomatous hyperplasias, 42 adenocarcinoma in situs, 38 minimally invasive adenocarcinomas, and 45 invasive pulmonary adenocarcinomas) were analyzed for lesion size, density, bubble-like sign, air bronchogram, vessel changes, margin, and tumour-lung interface. CT characteristics were compared among different histopathologic subtypes. Univariate and multivariate analysis were used to assess the relationship between CT characteristics of pGGN and lesion invasiveness, respectively.
  
  
  RESULTS
  There were statistically significant differences among histopathologic subtypes in lesion size, vessel changes, and tumour-lung interface (P<0.05). Univariate analysis revealed significant differences of vessel changes, margin and tumour-lung interface between preinvasive and invasive lesions (P<0.05). Logistic regression analysis showed that the vessel changes, unsmooth margin and clear tumour-lung interface were significant predictive factors for lesion invasiveness, with odds ratios (95% CI) of 2.57 (1.17-5.62), 1.83 (1.25-2.68) and 4.25 (1.78-10.14), respectively.
  
  
  CONCLUSIONS
  Invasive lesions are found in 55.3% of subcentimeter pGGNs in our cohort. Vessel changes, unsmooth margin, and clear lung-tumour interface may indicate the invasiveness of lung adenocarcinoma with subcentimeter pGGN.
  
  
  CONCLUSIONS
  • Invasive lesions were found in 55.3% of lung adenocarcinomas with subcentimeter pGGNs • Lesion size, vessel changes, and tumour-lung interface showed different among histopathologic subtypes • Vessel changes, unsmooth margin and clear tumour-lung interface were predictors for lesion invasiveness.
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.|Department of Radiology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Radiology, Navy General Hospital, 28 Fucheng Road, Beijing, 100048, China.
authors.forename: Shu-Ping
authors.initials: SP
authors.lastname: Tian
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Jing
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Yang
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.affiliation: Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. zhaoshaohong@aliyun.com.
authors.forename: Shao-Hong
authors.initials: SH
authors.lastname: Zhao
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000000981:diagnostic imaging / Q000473:pathology; D016017:Odds Ratio; D011230:Precancerous Conditions / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Adenocarcinoma; Ground-glass nodule; Histopathology; Lung neoplasms; Tomography, X-ray computed