title: Invasive aspergillosis related to ibrutinib therapy for chronic lymphocytic leukemia.
abstract: We report a case of invasive pulmonary aspergillosis in a patient taking ibrutinib, a Bruton's tyrosine kinase inhibitor used to treat refractory chronic lymphocytic leukemia. We hypothesize that ibrutinib promoted this infection by suppressing innate immune responses againstAspergillus. Clinicians should be aware of potentialAspergillusinfections in patients treated with this drug.
authors.affiliation: Division of Pulmonary & Critical Care Medicine, Veterans Affairs Portland Health Care System, Oregon Health & Science University, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States; Department of Medicine, Veterans Affairs Portland Health Care System, Oregon Health & Science University, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Arthurs
authors.affiliation: Department of Medicine, Veterans Affairs Portland Health Care System, Oregon Health & Science University, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States.
authors.forename: Kathy
authors.initials: K
authors.lastname: Wunderle
authors.affiliation: Department of Pathology, Veterans Affairs Portland Health Care System, Oregon Health & Science University, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States.
authors.forename: Maylee
authors.initials: M
authors.lastname: Hsu
authors.affiliation: Division of Pulmonary & Critical Care Medicine, Veterans Affairs Portland Health Care System, Oregon Health & Science University, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States; Department of Medicine, Veterans Affairs Portland Health Care System, Oregon Health & Science University, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States.
authors.forename: Suil
authors.initials: S
authors.lastname: Kim
keywords: Aspergillus; BAL, Bronchoalveolar lavage; BTK, Bruton's tyrosine kinase; Bruton's tyrosine kinase; CLL, Chronic lymphocytic leukemia; Chronic lymphocytic leukemia; Ibrutinib; Invasive aspergillosis; TLR, Toll-like receptor