title: The relationship of plasma creatinine (as eGFR) and high-sensitivity cardiac troponin and NT-proBNP concentrations in a hospital and community outpatient population.
abstract: OBJECTIVE
  While persons with overt renal failure have a well-described rise in troponin and NT-proBNP, it is less well described what the relationship is between cardiac markers and persons with impaired renal function, not requiring dialysis.
  
  
  METHODS
  We have collected ALL samples referred to our pathology practice over a 24h period and measured hs-cTnI, hs-cTnT, NT-proBNP, calculated the eGFR, and related our measurements to clinical outcomes.
  
  
  RESULTS
  For both men and women, for all of hs-cTnI, hs-cTnT and NT-proBNP, there was a graded response, as renal function worsened, the concentration of the cardiac marker increased.
  
  
  CONCLUSIONS
  There is a graded inverse relationship between eGFR and the concentrations of hs-cTnI, hs-cTnT and NT-proBNP. For women only there appeared to be an increase in mortality at lowest eGFR.
authors.affiliation: Department of Chemical Pathology, The Canberra Hospital, Canberra, ACT 2605, Australia; Australian National University Medical School, Canberra, ACT 2601, Australia.
authors.forename: Julia M
authors.initials: JM
authors.lastname: Potter
authors.affiliation: Department of Chemical Pathology, The Canberra Hospital, Canberra, ACT 2605, Australia.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Simpson
authors.affiliation: Department of Chemical Pathology, The Canberra Hospital, Canberra, ACT 2605, Australia.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kerrigan
authors.affiliation: Department of Chemical Pathology, The Canberra Hospital, Canberra, ACT 2605, Australia; Australian National University Medical School, Canberra, ACT 2601, Australia.
authors.forename: Emma
authors.initials: E
authors.lastname: Southcott
authors.affiliation: Department of Chemical Pathology, The Canberra Hospital, Canberra, ACT 2605, Australia.
authors.forename: Marie M
authors.initials: MM
authors.lastname: Salib
authors.affiliation: University of Canberra, ACT 2601, Australia; NSW Health Pathology, Chatswood, NSW 2067, Australia.
authors.forename: Gus
authors.initials: G
authors.lastname: Koerbin
authors.affiliation: Department of Chemical Pathology, The Canberra Hospital, Canberra, ACT 2605, Australia; Australian National University Medical School, Canberra, ACT 2601, Australia. Electronic address: peter.hickman@act.gov.au.
authors.forename: Peter E
authors.initials: PE
authors.lastname: Hickman
mesh_terms: D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010045:Outpatients; D051437:Renal Insufficiency / Q000097:blood*; D019209:Troponin C / Q000097:blood*
chemical_list: D015415:Biomarkers; D019209:Troponin C; D020097:Natriuretic Peptide, Brain; D003404:Creatinine
keywords: Cardiac troponin; NT-proBNP; eGFR