title: Parasitic Infections in Pregnancy Decrease Placental Transfer of Antipneumococcus Antibodies.
abstract: Many factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. However, little is known about the effect of maternal parasitic infection on placental antibody transfer. To investigate this, we selected from a parent study of 576 pregnant Kenyan women four groups of women with term deliveries (≥37 weeks), including uninfected women (n= 30) and women with solo infections with malaria (n= 30), hookworm (n= 30), or schistosomiasis (n= 10). Maternal plasma at delivery and infant cord blood were tested via multiplex fluorescent bead assay for IgG against 10 pneumococcal serotypes (PnPs 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F), diphtheria toxoid, andHaemophilus influenzaetype B. Infants born to mothers with prenatal malaria, hookworm, orSchistosoma haematobiuminfections were associated with a significantly reduced ratio of maternal to infant cord blood antibody concentration forStreptococcus pneumoniaeserotypes 1, 4, 5, 6B, 7F, 9V, and 18C compared to infants of uninfected mothers. Anti-diphtheria toxoid and anti-H. influenzaetype B IgG ratios were not significantly different among infection groups. Prenatal parasitic infections decrease the transfer of maternal IgG antibodies to infants for several serotypes ofS. pneumoniae.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA noahmck@stanford.edu.
authors.forename: Noah D
authors.identifier: http://orcid.org/0000-0001-6277-2733
authors.initials: ND
authors.lastname: McKittrick
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, Lucille Packard Children's Hospital at Stanford School of Medicine, Stanford, California, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Vu
authors.affiliation: Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: Indu
authors.initials: I
authors.lastname: Malhotra
authors.affiliation: Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
authors.forename: Charles H
authors.initials: CH
authors.lastname: King
authors.affiliation: Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya.
authors.forename: Francis
authors.initials: F
authors.lastname: Mutuku
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, Lucille Packard Children's Hospital at Stanford School of Medicine, Stanford, California, USA.
authors.forename: A Desiree
authors.initials: AD
authors.lastname: LaBeaud
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood / Q000378:metabolism*; D001692:Biological Transport; D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007231:Infant, Newborn; D007630:Kenya; D008297:Male; D008431:Maternal-Fetal Exchange; D010272:Parasitic Diseases / Q000473:pathology*; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000473:pathology*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
keywords: humoral immunity; parasites; placental antibody transfer; pregnancy