title: A Complex Interplay: Cognitive Behavioural Therapy for Severe Health Anxiety in Addison's Disease to Reduce Emergency Department Admissions.
abstract: BACKGROUND
  Addison's disease (AD) is a rare chronic illness caused by adrenocortical insufficiency. Due to the pivotal role of the regulating hormone cortisol in AD, there is a common symptom overlap between the presentation of anxiety and adrenal crisis. Previous literature has identified the prevalence of anxiety in endocrinological disorders, however there is a paucity of research examining the complex interplay between AD and anxiety.
  
  
  OBJECTIVE
  This paper describes a single case study of a patient with severe health anxiety and co-morbid AD. The aims of the study were to establish if standard cognitive behavioural therapy for health anxiety in AD can lead to a reduction in psychological distress, and whether this approach is an effective intervention for the reduction of Emergency Department admissions.
  
  
  METHODS
  A single case design was used, with pre- and post-measures of health anxiety, general anxiety and depression. Data on Emergency Department admissions prior to and following treatment were used to assess change in this domain.
  
  
  RESULTS
  Reliable and clinically significant reductions were seen across all measures, from severe to sub-clinical levels. There was a complete amelioration of Emergency Department admissions in the 12 months following completion of treatment.
  
  
  CONCLUSIONS
  This preliminary study provides a sound rationale for further research into AD complicated by anxiety. Findings support the clinical utility of the cognitive behavioural therapy model for complex presentations of AD, offering a potential treatment option where anxiety is elevated and interfering with self-management and leading to high levels of health service use.
authors.affiliation: Department of Psychology,University of Bath,Bath,UK.
authors.forename: Jo
authors.initials: J
authors.lastname: Daniels
authors.affiliation: Department of Psychology,University of Bath,Bath,UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sheils
mesh_terms: D000224:Addison Disease / Q000150:complications / Q000523:psychology* / Q000628:therapy*; D000328:Adult; D001007:Anxiety / Q000209:etiology / Q000523:psychology* / Q000628:therapy*; D015928:Cognitive Behavioral Therapy; D015897:Comorbidity; D003863:Depression / Q000150:complications / Q000628:therapy; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D013315:Stress, Psychological / Q000628:therapy
chemical_list: D006854:Hydrocortisone
keywords: Addison's disease; Emergency Department; cognitive behaviour therapy