title: The Relationship between Serum Carbonic Anhydrase I-II Autoantibody Levels and Diabetic Retinopathy in Type 1 Diabetes Patients.
abstract: OBJECTIVE
  To investigate the relationship between serum carbonic anhydrase I-II (CA-I and II) autoantibody levels and diabetic retinopathy (DRP) in cases with type 1 diabetes.
  
  
  METHODS
  A total of 37 type-1 diabetic patients, 17 with DRP (group 1) and 20 without (group 2), and 38 healthy control subjects (group 3) were included. CA-I and CA-II autoantibody levels were measured in serum samples obtained from each of the three groups and compared statistically. Additionally, the correlation between CA-I and CA-II autoantibody levels and the presence of diabetic macular edema was examined.
  
  
  RESULTS
  Mean measured CA-I autoantibody levels were 0.145±0.072, 0.117±0.047, and 0.138±0.061 ABSU in group 1, group 2, and group 3, respectively (p=0.327). The average CA-II autoantibody levels achieved in the same groups were 0.253±0.174, 0.155±0.137, and 0.131±0.085 ABSU, respectively (p=0.005). No significant difference was obtained between the subgroups of group 1, with macular edema (n=8) and without (n=9), in terms of both CA-I and CA-II autoantibody levels (p=0.501, p=0.178, respectively).
  
  
  CONCLUSIONS
  A significant correlation was observed between the development of DRP and serum CA-II autoantibody levels in type 1 diabetic cases. However, there was no correlation between the autoantibody levels and the presence of diabetic macular edema in cases with DRP.
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Ophthalmology, Trabzon, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Türk
authors.affiliation: Of State Hospital, Ophthalmology Clinic, Trabzon, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Mollamehmetoğlu
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Biochemistry, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Biochemistry, Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Menteşe
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Internal Medicine, Trabzon, Turkey.
authors.forename: İrfan
authors.initials: İ
authors.lastname: Nuhoğlu
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Internal Medicine, Trabzon, Turkey.
authors.forename: Cihangir
authors.initials: C
authors.lastname: Erem
authors.affiliation: Karadeniz Technical University Faculty of Medicine, Department of Ophthalmology, Trabzon, Turkey.
authors.forename: Halil İbrahim
authors.initials: Hİ
authors.lastname: İmamoğlu
keywords: Carbonic anhydrase I; carbonic anhydrase II; diabetes mellitus; diabetic retinopathy