title: Reference values for fasting serum resistin in healthy children and adolescents.
abstract: BACKGROUND
  Resistin is a hormone, mainly produced in macrophages and monocytes, believed to play an important role in the inflammatory response. It has been linked to several chronic diseases such as heart failure, inflammatory bowel disease, and insulin resistance. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum resistin concentrations.
  
  
  METHODS
  A total of 1191 healthy, non-obese Danish schoolchildren (727 girls) aged 6-18years (median 11.9) were included. Fasting serum resistin concentrations were quantitated by Human Resistin ELISA Development kit, Duo Set (R&D Systems) following optimization.
  
  
  RESULTS
  The overall median resistin concentration was 8.93ng/mL (interquartile range (IQR): 6.19-13.33, range 1.57-35.84) in boys and 10.42ng/mL (IQR: 7.25-15.68, range 1.60-44.00) in girls. The resistin concentration correlated to relative BMI in both boys (p=0.02) and girls (p<0.0001). Percentiles for each age group were calculated alongside smoothed percentile curves and an age correlated increase was demonstrated, albeit only in girls (p=0.02) and not in boys (p=0.35).
  
  
  CONCLUSIONS
  Fasting serum resistin concentrations differ between sexes in healthy children and adolescents and are correlated both with the sex- and age adjusted BMI, and in girls to age.
authors.affiliation: The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark. Electronic address: ulrik.lausten-thomsen@aphp.fr.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Lausten-Thomsen
authors.affiliation: Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Michael
authors.initials: M
authors.lastname: Christiansen
authors.affiliation: Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Paula Louise
authors.initials: PL
authors.lastname: Hedley
authors.affiliation: The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Tenna Ruest Haarmark
authors.initials: TRH
authors.lastname: Nielsen
authors.affiliation: The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Cilius Esmann
authors.initials: CE
authors.lastname: Fonvig
authors.affiliation: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Oluf
authors.initials: O
authors.lastname: Pedersen
authors.affiliation: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
authors.forename: Torben
authors.initials: T
authors.lastname: Hansen
authors.affiliation: The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, The Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jens-Christian
authors.initials: JC
authors.lastname: Holm
mesh_terms: D000293:Adolescent; D001774:Blood Chemical Analysis / Q000592:standards*; D002648:Child; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011627:Puberty; D012016:Reference Values; D052243:Resistin / Q000097:blood*; D012737:Sex Factors
chemical_list: D052243:Resistin
keywords: Adipokines; Adolescents; Children; Humans; Reference values; Resistin