title: Efficacy and safety of multimodal analgesic techniques for preventing chronic postsurgery pain under different surgical categories: a meta-analysis.
abstract: The purpose of this meta-analysis was to compare the efficacy and safety of regional anesthesia to manage chronic postsurgery pain. A systematic search of PubMed, EmBase, and the Cochrane Central Register of Controlled Trials was performed to identify randomized controlled trials that focused on chronic pain frequency, analgesic consumption, and adverse effects under different surgical categories. We collected 21 trials assessing 1,980 patients for our meta-analysis. The summary of relative risks (RRs) and standard mean differences (SMDs) were calculated to measure the treatment effect of regional anesthesia. Results indicated that regional anesthesia significantly reduced the frequency of postsurgery pain (RR, 0.69; 95% confidence interval [CI], 0.56-0.85; p < 0.001). The results showed significant differences in overall patient satisfaction between applications with and without regional anesthesia (SMD, 1.95; 95%CI, 0.83-3.06; p = 0.001); however in other results, there were no significant differences between the two groups. Subgroup analysis suggested that regional anesthesia treatment might differ according to country. In conclusion, our study indicated that regional anesthesia was effective and safe in reducing the frequency of postsurgery pain and improved overall patient satisfaction; however, studies on the long-term efficacy and safety of regional anesthesia are still required to further confirm these findings.
authors.affiliation: Department of Anesthesiology, First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology, Guangzhou Panyu Central Hopital of Panyu District, Guangzhou, 511400, Guangdong Province, China.
authors.forename: Youling
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Anesthesiology, First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China.
authors.forename: Jiying
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Department of Anesthesiology, First People's Hospital of Foshan, Foshan, 528000, Guangdong Province, China.
authors.forename: Xianjie
authors.initials: X
authors.lastname: Wen
authors.affiliation: Department of Anesthesiology, Eighth People's Hospital of Guangzhou, Guangzhou, 510060, Guangdong Province, China. gz8hcht@126.com.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Chen
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000758:Anesthesia / Q000009:adverse effects / Q000379:methods; D002908:Chronic Disease; D006801:Humans; D059408:Pain Management / Q000009:adverse effects / Q000379:methods; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000517:prevention & control*; D017060:Patient Satisfaction; D016896:Treatment Outcome
chemical_list: D000700:Analgesics