title: The association between retinal nerve fibre layer thickness and corpus callosum index in different clinical subtypes of multiple sclerosis.
abstract: The objective of this paper is to evaluate the association between physical disability in multiple sclerosis (MS) patients, the thickness of the retinal nerve fibre layer (RNFL) and corpus callosum volumes, as expressed by the corpus callosum index (CCI). This study was based on a cohort of 212 MS patients and 52 healthy control subjects, who were age and gender matched. The MS patients included 144 women and 177 relapsing-remitting MS (RRMS) patients. Peripapillary and volumetric optical coherence tomography (OCT) scans of the macula were performed using spectral-domain OCT technology. All magnetic resonance imaging (MRI) scans were performed using 1.5-T systems. CCI and RNFL were lower in MS than healthy control subjects (0.341 versus 0.386, p < 0.01 and 92.1 versus 105.0, p < 0.01). In addition, CCI correlated with RNFL (r = 0.464, p < 0.01). This was also true for the subgroup of patients with no history of optic neuritis (ON). There is a correlation between the thickness of the RNFL and CCI values in MS patients with no history of ON, which suggests that OCT might be a suitable marker for neurodegeneration in MS clinical trials.
authors.affiliation: Faculty of Medicine Neurology Department, Yuzuncu Yil University, 65000, Kampus Van, Turkey. vedatcilingir@yahoo.com.
authors.forename: Vedat
authors.initials: V
authors.lastname: Cilingir
authors.affiliation: Faculty of Medicine Ophthalmology Department, Yuzuncu Yil University, Van, Turkey.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Batur
authors.affiliation: Faculty of Medicine Radiology Department, Yuzuncu Yil University, Van, Turkey.
authors.forename: Mehmet Deniz
authors.initials: MD
authors.lastname: Bulut
authors.affiliation: Faculty of Medicine Neurology Department, Yuzuncu Yil University, 65000, Kampus Van, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Milanlioglu
authors.affiliation: Faculty of Medicine Neurology Department, Yuzuncu Yil University, 65000, Kampus Van, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Yılgor
authors.affiliation: Faculty of Medicine Radiology Department, Yuzuncu Yil University, Van, Turkey.
authors.forename: Abdussamet
authors.initials: A
authors.lastname: Batur
authors.affiliation: Faculty of Medicine Ophthalmology Department, Yuzuncu Yil University, Van, Turkey.
authors.forename: Tekin
authors.initials: T
authors.lastname: Yasar
authors.affiliation: Faculty of Medicine Neurology Department, Yuzuncu Yil University, 65000, Kampus Van, Turkey.
authors.forename: Temel
authors.initials: T
authors.lastname: Tombul
mesh_terms: D000328:Adult; D001369:Axons / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000473:pathology*; D009412:Nerve Fibers / Q000473:pathology*; D009902:Optic Neuritis / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods
keywords: Atrophy; Corpus callosum; Disability; Multiple sclerosis; Optical coherence tomography; Rentinal nerve fibre layer