title: Genome-wide association studies reveal additional related loci for fatty acid composition in a Duroc pig multigenerational population.
abstract: The aim of the present study was to detect quantitative trait loci affecting fatty acid composition in back fat and intramuscular fat in a Duroc pig population comprising seventh-generation pedigrees using genome-wide association studies (GWAS). In total, 305 animals were genotyped using single nucleotide polymorphisms (SNPs) array and five selected SNPs from regions containing known candidate genes related to fatty acid synthesis or metabolism. In total, 24 genome-wide significant SNP regions were detected in 12 traits, and 76 genome-wide suggestive SNP regions were detected in 33 traits. The Sus scrofa chromosome (SSC) 7 at 10.3 Mb was significantly associated with C17:0 in intramuscular fat, while the SSC9 at 13.6 Mb was significantly associated with C14:0 in intramuscular fat. The SSC12 at 1.0 Mb was significantly associated with C14:0 in back fat and the SSC14 at 121.0 Mb was significantly associated with C18:0 in intramuscular fat. These regions not only replicated previously reported loci containing some candidate genes involved in fatty acid composition (fatty acid synthase and stearoyl-CoA desaturase) but also included several additional related loci.
authors.affiliation: National Livestock Breeding Center, Nishigo, Fukushima, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Sato
authors.affiliation: National Livestock Breeding Center, Nishigo, Fukushima, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Uemoto
authors.affiliation: National Livestock Breeding Center, Nishigo, Fukushima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kikuchi
authors.affiliation: Miyazaki Branch of National Livestock Breeding Center, Kobayashi, Miyazaki, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Egawa
authors.affiliation: National Livestock Breeding Center, Nishigo, Fukushima, Japan.
authors.forename: Kimiko
authors.initials: K
authors.lastname: Kohira
authors.affiliation: National Livestock Breeding Center, Nishigo, Fukushima, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Saito
authors.affiliation: National Livestock Breeding Center, Nishigo, Fukushima, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Sakuma
authors.affiliation: Miyazaki Branch of National Livestock Breeding Center, Kobayashi, Miyazaki, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Miyashita
authors.affiliation: National Livestock Breeding Center, Nishigo, Fukushima, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Arata
authors.affiliation: Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001823:Body Composition / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics; D064429:Fatty Acid Synthases / Q000235:genetics; D005227:Fatty Acids / Q000378:metabolism*; D056726:Genetic Association Studies; D055106:Genome-Wide Association Study / Q000662:veterinary*; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D009132:Muscles / Q000378:metabolism*; D010375:Pedigree; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D013230:Stearoyl-CoA Desaturase / Q000235:genetics; D034421:Sus scrofa / Q000235:genetics* / Q000378:metabolism*
chemical_list: D005227:Fatty Acids; D013230:Stearoyl-CoA Desaturase; D064429:Fatty Acid Synthases
keywords: 
  GWAS
  ; Duroc pigs; fatty acid composition; known candidate genes