title: Cardioprotective effect of magnetic hydrogel nanocomposite loaded N,α-L-rhamnopyranosyl vincosamide isolated from Moringa oleifera leaves against doxorubicin-induced cardiac toxicity in rats: in vitro and in vivo studies.
abstract: Cardioprotective effect of N, α-L-rhamnopyranosyl vincosamide (VR), isolated from the leaves of Moringa oleifera plant in doxorubicin (Dox)-induced cardiac toxicity rats was evaluated. Twelve (12) rats were randomly selected into three groups; two rats received distilled water in the control group, five rats in group I received varying concentration of VR treatment, and group II containing five rats received varying concentration of VR-loaded magnetic hydrogel nanocomposite. Malondialdehyde (MDA), glutathione peroxidase (GSH) and superoxide dismutase (SOD) enzymes activities level were analysed after two weeks. In addition, the expression of three heart failure markers; beta major histocompatibility complex (β-MHC), atrial natriuretic peptide (ANP), and B type natriuretic peptide (BNP) were also evaluated. It was observed that the level of these markers expression decreases with an increase in VR concentration (p < 0.05). The reduced GSH and SOD level were increased after VR administration, this extract also reduced the initially increased MDA level in cardiac tissue. Pharmacokinetic parameters evaluation showed that nanogel treated rats possesses a significantly increased VR plasma concentration, Cmax, Kel, t½(a),t½(el),Kaand AUC. The result of this study indicated that VR may help to lower the dosage level, and reduces the treatment course in cardiovascular diseases (CVD). Our conclusion proposes the cardio-protective ability of the isolated VR and its beneficial effect via free radical scavenging properties.
authors.affiliation: a Department of Cardiology , Lorestan University of Medical Sciences , Khorramabad , Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Cheraghi
authors.affiliation: a Department of Cardiology , Lorestan University of Medical Sciences , Khorramabad , Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Namdari
authors.affiliation: a Department of Cardiology , Lorestan University of Medical Sciences , Khorramabad , Iran.
authors.forename: Hadis
authors.initials: H
authors.lastname: Daraee
authors.affiliation: b Department of Medical Biotechnology , School of Advanced Technologies in Medicine, Tehran University of Medical sciences , Tehran , Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Negahdari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D066126:Cardiotoxicity; D004317:Doxorubicin / Q000009:adverse effects; D020100:Hydrogels / Q000737:chemistry*; D026121:Indole Alkaloids / Q000494:pharmacology*; D058185:Magnetite Nanoparticles / Q000737:chemistry; D029588:Moringa oleifera / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; D020100:Hydrogels; D026121:Indole Alkaloids; D058185:Magnetite Nanoparticles; C000598491:vincosamide; D004317:Doxorubicin
keywords: Cardioprotective; Moringa oleifera; cardiac toxicity; doxorubicin; pharmacokinetics