title: [Application of array comparative genomic hybridization in prenatal diagnosis of a case with 5q35 deletion syndrome].
abstract: OBJECTIVE
  To use combined G-banding and array-comparative genomic hybridization (aCGH) for the prenatal diagnosis of a fetus with 5q35 deletion syndrome.
  
  
  METHODS
  Chromosomal karotypes of the fetus and parents were analyzed with G-banding analysis. aCGH was performed to detect minor chromosomal structural abnormalities.
  
  
  RESULTS
  The karyotype of the fetus was ascertained as 46, XY, t(5;10)(q35;p13), and the karyotypes of the parents were normal. aCGH has identified a de novo 1.68 Mb deletion at 5q35.2q35.3 and a 1.44 Mb duplication at 10p14p13.
  
  
  CONCLUSIONS
  aCGH has a higher resolution and greater accuracy for mapping chromosomal aberrations and is a useful supplement for G banding karyptyping analysis.
authors.affiliation: Department of Urology, the First People's Hospital of Zhengzhou, Zhengzhou,Henan 450004 China. fengzhanqi448590@sina.com; liuhongyanqhhy@126.com.
authors.forename: Zhanqi
authors.initials: Z
authors.lastname: Feng
authors.forename: Heping
authors.initials: H
authors.lastname: Hu
authors.forename: Changqing
authors.initials: C
authors.lastname: Mao
authors.forename: Dingzhan
authors.initials: D
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Shiling
authors.initials: S
authors.lastname: Liu
authors.forename: Zhian
authors.initials: Z
authors.lastname: Jing
authors.forename: Hongyan
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D055028:Comparative Genomic Hybridization; D003410:Cri-du-Chat Syndrome / Q000175:diagnosis / Q000196:embryology / Q000235:genetics*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D011296:Prenatal Diagnosis; D014314:Trisomy / Q000175:diagnosis / Q000235:genetics*