title: Thyroid-Stimulating Hormone, Thyroid Hormones, and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study.
abstract: Background:The effects of thyroid-stimulating hormone (TSH) and thyroid hormones on the development of human papillary thyroid cancer (PTC) remain poorly understood.Methods:The study population consisted of 741 (341 women, 400 men) histologically confirmed PTC cases and 741 matched controls with prediagnostic serum samples stored in the Department of Defense Serum Repository. Concentrations of TSH, total T3, total T4, and free T4 were measured in serum samples. Conditional logistic regression models were used to calculate ORs and 95% confidence intervals (CI).Results:The median time between blood draw and PTC diagnosis was 1,454 days. Compared with the middle tertile of TSH levels within the normal range, serum TSH levels below the normal range were associated with an elevated risk of PTC among women (OR, 3.74; 95% CI, 1.53-9.19) but not men. TSH levels above the normal range were associated with an increased risk of PTC among men (OR, 1.96; 95% CI, 1.04-3.66) but not women. The risk of PTC decreased with increasing TSH levels within the normal range among both men and women (Ptrend= 0.0005 and 0.041, respectively).Conclusions:We found a significantly increased risk of PTC associated with TSH levels below the normal range among women and with TSH levels above the normal range among men. An inverse association between PTC and TSH levels within the normal range was observed among both men and women.Impact:These results could have significant clinical implications for physicians who are managing patients with abnormal thyroid functions and those with thyroidectomy.Cancer Epidemiol Biomarkers Prev; 26(8); 1209-18. ©2017 AACR.
authors.affiliation: Department of Surgery, Yale School of Medicine, Yale Cancer Center, New Haven, Connecticut.
authors.forename: Huang
authors.initials: H
authors.lastname: Huang
authors.affiliation: Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Department of Preventive Medicine & Biostatistics, Bethesda, Maryland.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rusiecki
authors.affiliation: Yale School of Public Health, New Haven, Connecticut.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.affiliation: Yale School of Public Health, New Haven, Connecticut.|Cancer Institute & Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yingtai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Yale School of Public Health, New Haven, Connecticut.
authors.forename: Shuangge
authors.initials: S
authors.lastname: Ma
authors.affiliation: Yale School of Public Health, New Haven, Connecticut.|Epidemiology Program, University of Hawaii Cancer Center, Hawaii.
authors.forename: Herbert
authors.initials: H
authors.lastname: Yu
authors.affiliation: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
authors.forename: Mary H
authors.initials: MH
authors.lastname: Ward
authors.affiliation: Endocrine Neoplasia Institute, Miami Cancer Center, Miami, Florida.
authors.forename: Robert
authors.initials: R
authors.lastname: Udelsman
authors.affiliation: Department of Surgery, Yale School of Medicine, Yale Cancer Center, New Haven, Connecticut. yawei.zhang@yale.edu.|Yale School of Public Health, New Haven, Connecticut.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000453:epidemiology*; D013972:Thyrotropin / Q000378:metabolism*
chemical_list: D013972:Thyrotropin