title: Cholesterol metabolism in pathogenesis of osteoarthritis disease.
abstract: Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder associated with mechanical stress and aging but also a 'metabolic syndrome' in which several risk factors work together to contribute to disease initiation and/or development. One such metabolic risk factor could be high cholesterol levels in the body. Even though high cholesterol level is a well-known risk factor for cardiovascular disorders, its possible role in musculoskeletal diseases, particularly OA, is not clear. The authors discuss the fundamental viewpoints on cholesterol involvement in the pathogenesis of OA, stressing the need for understanding the molecular mechanisms behind this association. This is the area of research needed to provide knowledge on how one should live to prevent OA development as well as to suggest new targets for drug therapy.
authors.affiliation: Institute of Health and Biomedical Innovation, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Qld, Australia.
authors.forename: Saba
authors.initials: S
authors.lastname: Farnaghi
authors.affiliation: Institute of Health and Biomedical Innovation, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Qld, Australia.
authors.forename: Ross
authors.initials: R
authors.lastname: Crawford
authors.affiliation: Institute of Health and Biomedical Innovation, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Qld, Australia.
authors.forename: Yin
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Institute of Health and Biomedical Innovation, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Qld, Australia.
authors.forename: Indira
authors.initials: I
authors.lastname: Prasadam
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism*; D018752:Diet, Fat-Restricted; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism; D007596:Joints / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D010003:Osteoarthritis / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D018384:Oxidative Stress; D012307:Risk Factors; D040242:Risk Reduction Behavior; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D018501:Antirheumatic Agents; D018836:Inflammation Mediators; D002784:Cholesterol
keywords: cholesterol; mitochondria; osteoarthritis; oxidative stress and cartilage