title: Norfloxacin and metronidazole topical formulations for effective treatment of bacterial infections and burn wounds.
abstract: BACKGROUND
  Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination withCurcuma longain various topical (ointments, gels, and creams) and transdermal drug delivery systems.
  
  
  OBJECTIVE
  Keeping these facts in consideration, we have made an another attempt to prepare semisolid formulations containing 1% w/w of norfloxacin and metronidazole with different bases like Carbopol, polyethylene glycol, and hydroxypropylmethyl cellulose for effective treatment of bacterial infections and burn wounds. The prepared formulations were evaluated for physicochemical parameters,in vitrodrug release, antimicrobial activity, and burn wound healing properties.
  
  
  RESULTS
  The prepared formulations were compared with Silver Sulfadiazine cream 1%, USP. Antimicrobial activity of norfloxacin semisolid formulations was found to be equally effective against both aerobic and anaerobic bacteria in comparison to a marketed formulation of Silver Sulfadiazine 1% cream, USP. Based on the burn wound healing property, the prepared norfloxacin semisolid formulation was found to be in good agreement with marketed Silver Sulfadiazine 1% cream, USP.
  
  
  CONCLUSIONS
  These findings suggest formulations containing norfloxacin and metronidazole may also prove as an effective alternative for existing remedies in the treatment of bacterial infections and burn wounds.
authors.affiliation: School of Pharmacy and Biomedical Sciences, The University of Newcastle , Newcastle, Callaghan, Australia.
authors.forename: Kamal
authors.initials: K
authors.lastname: Dua
authors.affiliation: Amity Institute of Pharmacy, Amity University Uttar Pradesh , Lucknow, India.
authors.forename: Venkata Ramana
authors.initials: VR
authors.lastname: Malipeddi
authors.affiliation: Department of Pharmaceutics, Sinhgad Technical Education Society, Smt. Kashibai Navale College of Pharmacy , Pune, Maharashtra, India.
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Madan
authors.affiliation: School of Medicine, The University of Newcastle , Newcastle, Callaghan, Australia.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Gupta
authors.affiliation: Department of Pathology, Perdana University , Serdang, Selangor, Malaysia.
authors.forename: Srikumar
authors.initials: S
authors.lastname: Chakravarthi
authors.affiliation: Laureate Institute of Pharmacy , Kangra, Himachal Pradesh, India.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Awasthi
authors.affiliation: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo , São Paulo, Brazil.
authors.forename: Irene Satiko
authors.initials: IS
authors.lastname: Kikuchi
authors.affiliation: Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo , São Paulo, Brazil.
authors.forename: Terezinha
authors.initials: T
authors.lastname: De Jesus Andreoli Pinto
keywords: burns; gels; infection; norfloxacin; ointments; transdermal