title: Tablet compression tooling - Impact of punch face edge modification.
abstract: The influence of punch face edge geometry modification on tablet compression and the properties of the resultant tablets produced on a rotary press were investigated. The results revealed that tablets produced from the punches with radius edge face geometry consistently displayed better physical quality; higher tensile strength and lower capping tendency. Modification of the angled edge of the bevel face to the curved edge of the radius face, enabled deeper punch penetration in the die cavity during the compression cycle, bringing about greater compact densification. Improved die fill packing increased interparticulate bond formation and helped to dissipate destructive elasticity within the compact, consequently reduced tablet expansion during the decompression phase. The positive impact of punch face edge modification was also more noticeable at a higher turret speed. The application of the precompression force along with dwell time extension amplified the tableting performance of radius edge punch face design to a greater extent when compared to bevel edge punch face design. This could be attributed to the enhanced packing efficiency at both precompression and main compression stages.
authors.affiliation: GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore.
authors.forename: Parthiban
authors.initials: P
authors.lastname: Anbalagan
authors.affiliation: GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore.
authors.forename: Paul Wan Sia
authors.initials: PWS
authors.lastname: Heng
authors.affiliation: GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive, 117543, Singapore. Electronic address: phalcv@nus.edu.sg.
authors.forename: Celine Valeria
authors.initials: CV
authors.lastname: Liew
mesh_terms: D004339:Drug Compounding; D004548:Elasticity; D011312:Pressure; D013607:Tablets; D013718:Tensile Strength
chemical_list: D013607:Tablets
keywords: Capping; Powder compaction; Punch face; Tablet compression tooling