title: Correspondence between fMRI and electrophysiology during visual motion processing in human MT.
abstract: Changes in brain neuronal activity are reflected by hemodynamic responses mapped through Blood Oxygenation Level Dependent (BOLD) functional magnetic resonance imaging (fMRI), a primary tool to measure brain functioning non-invasively. However, the exact relationship between hemodynamics and neuronal function is still a matter of debate. Here, we combine 3T BOLD fMRI and High Frequency Band (HFB) electrocorticography (ECoG) signals to investigate the relationship between neuronal activity and hemodynamic responses in the human Middle Temporal complex (hMT+), a higher order brain area involved in visual motion processing. We modulated the ECoG HFB and fMRI BOLD responses with a visual stimulus moving at different temporal frequencies, and compared measured BOLD responses to estimated BOLD responses that were predicted from the temporal profile of the HFB power change. We show that BOLD responses under an electrode over hMT+ can be well predicted not only be the strength of the neuronal response but also by the temporal profile of the HFB responses recorded by this electrode. Our results point to a linear relationship between BOLD and neuronal activity in hMT+, extending previous findings on primary cortex to higher order cortex.
authors.affiliation: Department of Neurosurgery and Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Anna
authors.initials: A
authors.lastname: Gaglianese
authors.affiliation: Department of Neurosurgery and Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Mariska J
authors.initials: MJ
authors.lastname: Vansteensel
authors.affiliation: Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, 3584 CS, The Netherlands.
authors.forename: Ben M
authors.initials: BM
authors.lastname: Harvey
authors.affiliation: Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, 3584 CS, The Netherlands; Spinoza Center for Neuroimaging, Amsterdam, The Netherlands.
authors.forename: Serge O
authors.initials: SO
authors.lastname: Dumoulin
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: N.Petridou@umcutrecht.nl.
authors.forename: Natalia
authors.initials: N
authors.lastname: Petridou
authors.affiliation: Department of Neurosurgery and Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Nick F
authors.initials: NF
authors.lastname: Ramsey
mesh_terms: D000328:Adult; D000069280:Electrocorticography / Q000379:methods*; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D000069336:Neurovascular Coupling / Q000502:physiology*; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000502:physiology*
keywords: 3T fMRI; Blood Oxygenation Level Dependent (BOLD); Brain; Electrocorticography (ECoG); Neurovascular coupling; hMT+