title: Review of hypoxaemia in anaesthetized horses: predisposing factors, consequences and management.
abstract: OBJECTIVE
  To discuss how hypoxaemia might be harmful and why horses are particularly predisposed to developing it, to review the strategies that are used to manage hypoxaemia in anaesthetized horses, and to describe how successful these strategies are and the adverse effects associated with them.
  
  
  METHODS
  Google Scholar and PubMed, using the search terms horse, pony, exercise, anaesthesia, hypoxaemia, oxygen, mortality, morbidity and ventilation perfusion mismatch.
  
  
  CONCLUSIONS
  Although there is no evidence that hypoxaemia is associated with increased morbidity and mortality in anaesthetized horses, most anaesthetists would agree that it is important to recognise and prevent or treat it. Favourable anatomical and physiological adaptations of a horse for exercise adversely affect gas exchange once the animal is recumbent. Hypoxaemia is recognised more frequently in horses than in other domestic species during general anaesthesia, although its incidence in healthy horses remains unreported. Management of hypoxaemia in anaesthetized horses is challenging and often unsuccessful. Positive pressure ventilation strategies to address alveolar atelectasis in humans have been modified for implementation in recumbent anaesthetized horses, but are often accompanied by unpredictable and unacceptable cardiopulmonary adverse effects, and some strategies are difficult or impossible to achieve in adult horses. Furthermore, anticipated beneficial effects of these techniques are inconsistent. Increasing the inspired fraction of oxygen during anaesthesia is often unsuccessful since much of the impairment in gas exchange is a direct result of shunt. Alternative approaches to the problem involve manipulation of pulmonary blood away from atelectatic regions of the lung to better ventilated areas. However, further work is essential, with particular focus on survival associated with general anaesthesia in horses, before any technique can be accepted into widespread clinical use.
authors.affiliation: Institute of Biodiversity, Animal Health and Comparative Medicine, School of Veterinary Medicine, University of Glasgow, Glasgow, UK. Electronic address: adam.auckburally@glasgow.ac.uk.
authors.forename: Adam
authors.initials: A
authors.lastname: Auckburally
authors.affiliation: Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
authors.forename: Görel
authors.initials: G
authors.lastname: Nyman
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D015984:Causality; D006734:Horse Diseases / Q000209:etiology* / Q000628:therapy; D006736:Horses; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D010100:Oxygen / Q000008:administration & dosage; D056888:Patient Positioning / Q000009:adverse effects / Q000662:veterinary; D001261:Pulmonary Atelectasis; D012119:Respiration
chemical_list: D010100:Oxygen
keywords: anaesthesia; horses; hypoxaemia; management