title: Physiologically Based Pharmacokinetic Modeling of Drug Transporters to Facilitate Individualized Dose Prediction.
abstract: Physiologically based pharmacokinetic modeling is a commonly used strategy in the drug development and regulatory submissions. This commentary provides a critical overview of the current status of physiologically based pharmacokinetic methodologies to predict transporter-mediated pharmacokinetics, in addition to the impact of disease and genetics with respect to local and systemic concentration.
authors.affiliation: Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993. Electronic address: Aleksandra.Galetin@manchester.ac.uk.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Galetin
authors.affiliation: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993.
authors.forename: Shiew-Mei
authors.initials: SM
authors.lastname: Huang
mesh_terms: D001692:Biological Transport / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D010599:Pharmacokinetics; D057285:Precision Medicine / Q000379:methods
chemical_list: D004364:Pharmaceutical Preparations
keywords: pharmacokinetic/pharmacodynamic models; transporters