title: Four New Nanaomycins Produced by Streptomyces hebeiensis Derived from Lichen.
abstract: Four new nanaomycins (1 - 4), together with two known compounds, nanaomycin αA (5) and nanaomycin βA (6) were isolated from a fermentation broth of Streptomyces hebeiensis derived from lichen. The structures of the new nanaomycins 1 - 4 were established using comprehensive NMR spectroscopic data analysis as well as UV, IR, and MS data. The antimicrobial activities of 1 - 6 were evaluated against Gram-positive bacteria and fungus. Compounds 5 and 6 showed antimicrobial activities against the test microorganisms, while 1 - 4 were inactive at 100 μg/ml.
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
authors.forename: Chengbin
authors.initials: C
authors.lastname: Liu
authors.affiliation: Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lei
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
authors.forename: Xiu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
authors.forename: Qingjuan
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.affiliation: Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
authors.forename: Xueshi
authors.initials: X
authors.lastname: Huang
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008011:Lichens / Q000378:metabolism*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000302:isolation & purification*; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry*; D000095622:Benzoisochromanequinones
chemical_list: D000890:Anti-Infective Agents; D009285:Naphthoquinones; C008638:nanaomycin A; D000095622:Benzoisochromanequinones
keywords: 
  Streptomyces hebeiensis
  ; Antimicrobial activity; Lichen; Nanaomycin