title: Factors that influence the neurobiological effects of exercise likely extend beyond age and intensity in people with major depression.
abstract: We recently conducted a comprehensive systematic review of neurobiological effects of exercise on major depressive disorder. A subsequent letter suggested that we should consider children and adolescent and raised the importance of how intensity may mediate neurobiological response in people with depression. Here, we discuss these comments regarding our review, in addition to proposing that other factors, such type, duration, frequency, and adherence, may also importantly influence neurobiological response, based on recent meta-analyses demonstrating these other aspects of physical activity also moderate dropout rates and effect sizes from exercise upon depression.
authors.affiliation: Mestrado em Saúde e Desenvolvimento Humano, Unilasalle, Canoas, Brazil; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Electronic address: felipe.schuch@unilasalle.edu.br.
authors.forename: Felipe Barreto
authors.initials: FB
authors.lastname: Schuch
authors.affiliation: Programa de Pós-graduação em Ciências do Exercício e do Esporte, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Andrea Camaz
authors.initials: AC
authors.lastname: Deslandes
authors.affiliation: Health Service and Population Research Department, Institute of Psychiatry, King's College London, London, UK; Physiotherapy Department, South London and Maudsley NHS Foundation Trust, London, UK.
authors.forename: Brendon
authors.initials: B
authors.lastname: Stubbs
authors.affiliation: Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Natan Pereira
authors.initials: NP
authors.lastname: Gosmann
authors.affiliation: Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Cristiano Tschiedel Belem da
authors.initials: CTBD
authors.lastname: Silva
authors.affiliation: Mestrado em Saúde e Desenvolvimento Humano, Unilasalle, Canoas, Brazil; Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Marcelo Pio de Almeida
authors.initials: MPA
authors.lastname: Fleck
mesh_terms: D003863:Depression; D003865:Major Depressive Disorder; D015444:Exercise; D005081:Exercise Therapy; D006801:Humans
keywords: Adherence; Depression; Exercise; Intensity; Neurobiological