title: Copper(i)-catalyzed ring-opening cyanation of cyclopropanols.
abstract: A copper(i)-catalyzed ring-opening cyanation of cyclopropanols was developed. The reaction provides an alternative method to achieve β-cyano ketones efficiently. This reaction exhibits good functional group compatibility under mild conditions and can be scaled up to the gram scale. Preliminary mechanistic studies suggest that the reaction might go through a free radical process.
authors.affiliation: School of Chemistry and Chemical Engineering, School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China. hjxu@hfut.edu.cn.
authors.forename: Yi-Si
authors.initials: YS
authors.lastname: Feng
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Shu
authors.forename: Ping
authors.initials: P
authors.lastname: Cao
authors.forename: Tao
authors.initials: T
authors.lastname: Xu
authors.forename: Hua-Jian
authors.initials: HJ
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry*
chemical_list: D004988:Ethers, Cyclic; D007659:Ketones; D009570:Nitriles; C043657:cyclopropanol; D003300:Copper