title: Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow.
abstract: Differentiation of hematopoietic stem cells into distinct cell types was thought to occur through a series of discrete, stable progenitor states. Work from Velten et al. (2017) now shows that hematopoietic cells differentiate via a mechanism of continuous lineage priming and thus represent a CLOUD-HSPC.
authors.affiliation: Department of Medicine, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511, USA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: karen.hirschi@yale.edu.
authors.forename: Karen K
authors.initials: KK
authors.lastname: Hirschi
authors.affiliation: Department of Medicine, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511, USA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: stefania.nicoli@yale.edu.
authors.forename: Stefania
authors.initials: S
authors.lastname: Nicoli
authors.affiliation: Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Walsh
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology; D014197:Trees