title: Ion channelopathies and migraine pathogenesis.
abstract: Migraine is a common neurological disorder that affects approximately 12-20% of the general adult population. Migraine pathogenesis is complex and not wholly understood. Molecular genetic investigations, imaging and biochemical studies, have unveiled a number of interconnected neurological pathways which seem to have a cause and effect component integral to its cause. Much weight of migraine attack initiation can be placed on the initial trigger and the pathways involved in its neuronal counter reaction. Ion channels play a large role in the generation, portrayal and mitigation of the brains response to external triggers. Several genetic studies have identified and implicated a number of ion channelopathy genes which may contribute to this generalised process. This review will focus on the genetics of migraine with particular emphasis placed on the potentially important role genes HEPH (responsible for iron transport and homeostasis) and KCNK18 (important for the transport and homeostasis of potassium) play in migraine cause.
authors.affiliation: Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
authors.forename: Cassie L
authors.initials: CL
authors.lastname: Albury
authors.affiliation: Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
authors.forename: Shani
authors.initials: S
authors.lastname: Stuart
authors.affiliation: Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
authors.forename: Larisa M
authors.initials: LM
authors.lastname: Haupt
authors.affiliation: Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia. lyn.griffiths@qut.edu.au.
authors.forename: Lyn R
authors.initials: LR
authors.lastname: Griffiths
mesh_terms: D000328:Adult; D053447:Channelopathies / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008881:Migraine Disorders / Q000235:genetics* / Q000473:pathology; D059226:Nociceptive Pain / Q000235:genetics* / Q000473:pathology; D015221:Potassium Channels / Q000235:genetics* / Q000502:physiology
chemical_list: C492164:HEPH protein, human; C476574:KCNK18 protein, human; D008565:Membrane Proteins; D015221:Potassium Channels
keywords: HEPH; Hephaestin; Ion channelopathies; KCNK18; Migraine; TRESK