title: Acute Kidney Disease After Total Hip and Knee Arthroplasty: Incidence and Associated Factors.
abstract: The development of acute kidney disease (AKD) following total joint arthroplasty has not been well characterized in the literature. We sought to calculate the incidence and identify risk factors associated with postoperative AKD for patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA).
  
  
  
  A total of 1000 consecutive cases (860 unique patients, including revisions) of TKA or THA performed between January 2010 and May 2016 were identified. Seventy-nine cases were excluded due to pre-existing kidney dysfunction and 23 additional cases were excluded due to incomplete data, resulting in 898 cases included in the study. There were 492 females and 406 males with a mean age of 58.1 years (range, 14-93 years). The Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease criteria and serum creatinine values were used to determine AKD status. Multiple logistic regression modeling was used to identify postoperative AKD risk factors.
  
  
  
  Overall incidence of postoperative AKD was 6.8% (n = 61). Use of perioperative angiotensin receptor blocker (ARBs) or angiotensin-converting enzyme inhibitors (ACEi) (odds ratio [OR] = 2.09; P = .030), increasing body mass index (BMI) (OR = 1.58 per 10 kg/m2; P = .014), and use of vancomycin perioperatively (OR = 1.91; P = .021) were associated with increased odds of development of postoperative AKD.
  
  
  
  A 6.8% incidence rate of postoperative AKD was noted in patients undergoing TKA or THA. Perioperative use of ARBs/ACEi, perioperative vancomycin use, and increased BMI were associated with increased odds of postoperative AKD.
authors.affiliation: The Ohio State University College of Medicine, Columbus, Ohio.
authors.forename: Eric X
authors.initials: EX
authors.lastname: Jiang
authors.affiliation: Department of Orthopaedics, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
authors.forename: Hrishikesh C
authors.initials: HC
authors.lastname: Gogineni
authors.affiliation: Department of Orthopaedics, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
authors.forename: Joel L
authors.initials: JL
authors.lastname: Mayerson
authors.affiliation: Department of Orthopaedics, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Glassman
authors.affiliation: Department of Orthopaedics, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Magnussen
authors.affiliation: Department of Orthopaedics, Wexner Medical Center, The Ohio State University, Columbus, Ohio.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Scharschmidt
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D014640:Vancomycin; D055815:Young Adult
chemical_list: D014640:Vancomycin
keywords: RIFLE criteria; acute kidney disease; complications; risk factors; total joint arthroplasty