title: Laser interstitial thermotherapy application for breast surgery: Current situation and new trends.
abstract: While breast specialists debate on therapeutic de-escalation in breast cancer, the treatment of benign lesions is also discussed in relation to new percutaneous ablation techniques. The purpose of these innovations is to minimize potential morbidity. Laser Interstitial ThermoTherapy (LITT) is an option for the ablation of targeted nodules. This review evaluated the scientific publications investigating the LITT approach in malignant and benign breast disease. Three preclinical studies and eight clinical studies (2 studies including fibroadenomas and 6 studies including breast cancers) were reviewed. Although the feasibility and safety of LITT have been confirmed in a phase I trial, heterogeneous inclusion criteria and methods seem to be the main reason for LITT not being yet an extensively used treatment option. In conclusion, further development is necessary before this technique can be used in daily practice.
authors.affiliation: Université de Lille - Faculté de Médecine, F-59000, Lille, France; Service de gynécologie-obstétrique - CHU Lille, F-59000, Lille, France; Inserm, U1189, ONCOTHAI-1 Avenue Oscar Lambret, 59037, Lille Cedex, France. Electronic address: yohan.kerbage@gmail.com.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Kerbage
authors.affiliation: Université de Lille - Faculté de Médecine, F-59000, Lille, France; Inserm, U1189, ONCOTHAI-1 Avenue Oscar Lambret, 59037, Lille Cedex, France. Electronic address: nacim.betrouni@inserm.fr.
authors.forename: Nacim
authors.initials: N
authors.lastname: Betrouni
authors.affiliation: Université de Lille - Faculté de Médecine, F-59000, Lille, France; Service de gynécologie-obstétrique - CHU Lille, F-59000, Lille, France; Inserm, U1189, ONCOTHAI-1 Avenue Oscar Lambret, 59037, Lille Cedex, France. Electronic address: pierre.collinet@chru-lille.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Collinet
authors.affiliation: Université de Lille - Faculté de Médecine, F-59000, Lille, France; Service de gynécologie-obstétrique - CHU Lille, F-59000, Lille, France. Electronic address: henri.azais@chru-lille.fr.
authors.forename: Henri
authors.initials: H
authors.lastname: Azaïs
authors.affiliation: Université de Lille - Faculté de Médecine, F-59000, Lille, France; Inserm, U1189, ONCOTHAI-1 Avenue Oscar Lambret, 59037, Lille Cedex, France. Electronic address: serge.mordon@inserm.fr.
authors.forename: Serge
authors.initials: S
authors.lastname: Mordon
authors.affiliation: Inserm, U1189, ONCOTHAI-1 Avenue Oscar Lambret, 59037, Lille Cedex, France. Electronic address: anne-sophie.vignion@inserm.fr.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Dewalle-Vignion
authors.affiliation: Université de Lille - Faculté de Médecine, F-59000, Lille, France; Service de gynécologie-obstétrique - CHU Lille, F-59000, Lille, France; Inserm, U1189, ONCOTHAI-1 Avenue Oscar Lambret, 59037, Lille Cedex, France. Electronic address: benmerlot@gmail.com.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Merlot
mesh_terms: D001941:Breast Diseases / Q000628:therapy*; D001943:Breast Neoplasms / Q000628:therapy*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods / Q000639:trends*; D053685:Laser Therapy / Q000379:methods / Q000639:trends*
keywords: Breast cancer; Interstitial; Laser; Minimally invasive; Thermotherapy