title: [Being physically active modifies the detrimental effect of sedentary behavior on obesity and cardiometabolic markers in adults].
abstract: BACKGROUND
  Sedentary behavior is a major risk factor for cardiovascular disease and mortality.
  
  
  OBJECTIVE
  To investigate whether the associations between sedentary behavior and cardiometabolic markers differs across physical activity levels.
  
  
  METHODS
  Cross sectional study of 314 participants aged 18 to 65 years. Body mass index (BMI) and waist circumference were measured, and body fat was derived from the sum of four skinfolds. Physical activity was measured objectively using accelerometers (Actigraph GT1M, USA®). A fasting blood sample was obtained to measure glucose, insulin, HOMA-IR, lipid profile and high sensitive C reactive protein (hsCRP). Those participants with an activity level > 600 MET.min-1.week-1 were classified as physically active.
  
  
  RESULTS
  Thirty four percent of participants were physically inactive and spent an average of 8.7 h.day-1 in sedentary pursuits. Physically inactive individuals had poorer cardiometabolic health than their physically active counterparts. Per one hour decrease in overall sedentary behavior, there was a significant improvement in glucose (-8.46 and -4.68 mg.dl-1), insulin (-2.12 and -1.77 pmol.l-1), HOMA-IR (-0.81 and -0.56) BMI (-0.93 and -0.62 kg.m-2) and waist circumference (-2.32 and -1.65 cm) in physically active and inactive participants, respectively.
  
  
  CONCLUSIONS
  Being physically active may modify the detrimental effects of sedentary behavior on cardiometabolic and obesity-related traits.
authors.affiliation: Departamento de Educación Física, Facultad de Educación, Universidad de Concepción, Concepción, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Salas
authors.affiliation: Escuela de Educación Física, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
authors.forename: Carlos
authors.initials: C
authors.lastname: Cristi-Montero
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, United Kingdom, carlos.celis@glasgow.ac.uk.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Departamento de Nutrición y Dietética, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
authors.forename: Eliana
authors.initials: E
authors.lastname: Durán
authors.affiliation: Departamento de Nutrición y Dietética, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Labraña
authors.affiliation: Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
authors.forename: María Adela
authors.initials: MA
authors.lastname: Martínez
authors.affiliation: Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Leiva
authors.affiliation: Núcleo de investigación en Salud, Actividad Física y Deporte, Universidad de Los Lagos, Osorno, Chile.
authors.forename: Cristian
authors.initials: C
authors.lastname: Alvarez
authors.affiliation: Departamento de Educación Física, Deporte y Recreación, Universidad de La Frontera, Temuco, Chile.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Aguilar-Farías
authors.affiliation: Departamento de Ciencias de la Actividad Física, Universidad de Los Lagos, Osorno, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Ramírez-Campillo
authors.affiliation: Universidad del Biobío, Chillan, Chile.
authors.forename: Ximena Díaz
authors.initials: XD
authors.lastname: Martínez
authors.affiliation: Departamento de Trabajo Social, INACAP, Valdivia, Chile.
authors.forename: Ruth
authors.initials: R
authors.lastname: Sanzana-Inzunza
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, United Kingdom, carlos.celis@glasgow.ac.uk.
authors.forename: Carlos
authors.initials: C
authors.lastname: Celis-Morales
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004522:Educational Status; D015444:Exercise / Q000502:physiology*; D005260:Female; D038321:Glycemic Index; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D012016:Reference Values; D012307:Risk Factors; D057185:Sedentary Behavior; D012737:Sex Factors; D018709:Statistics, Nonparametric; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol