title: A Strategy for Precise Treatment of Cardiac Malignant Neoplasms.
abstract: The prevalence of cardiac malignant neoplasms in the general population has been shown to be significant higher than what was previously estimated, yet their treatment has remained difficult and effective therapies are lacking. In the current study, we developed a novel thermotherapy in which PEG-functionalized carbon nanotubes were injected into the tumor regions to assist in the targeted delivery of infrared radiation energy with minimal hyperthermic damage to the surrounding normal tissues. In a mouse model of cardiac malignant neoplasms, the injected carbon nanotubes could rapidly induce coagulative necrosis of tumor tissues when exposed to infrared irradiation. In accordance, the treatment was also found to result in a restoration of heart functions and a concomitant increase of survival rate in mice. Taken together, our carbon nanotube-based thermotherapy successfully addressed the difficulty facing conventional laser ablation methods with regard to off-target thermal injury, and could pave the way for the development of more effective therapies against cardiac malignant neoplasms.
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
authors.forename: Wenshuo
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
authors.forename: Jinqiang
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200043, P. R. China.
authors.forename: Hongyue
authors.initials: H
authors.lastname: Tao
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Nian
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
authors.forename: Lai
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of General Practice, Pujiang Community Health Service Center, Minhang Districts, Shanghai, 201112, P. R. China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Ling
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.
authors.forename: Limin
authors.initials: L
authors.lastname: Xia
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D006334:Heart Function Tests; D006338:Heart Neoplasms / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D007267:Injections; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry; D016019:Survival Analysis; D013696:Temperature; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D011092:Polyethylene Glycols