title: Squeezing out in a "tug of war": The role of myosin in neural stem cell delamination.
abstract: Neural stem cells or neuroblasts in theDrosophila melanogasterembryo delaminate as single cells from the embryonic epidermis to give rise to the nervous system. Using this accessible system to examine the molecular mechanisms of cell ingression at a high temporal and spatial resolution, in this issue, Simões et al. (2017.J. Cell Biol.https://doi.org/10.1083/jcb.201608038) reveal that myosin-driven anisotropic junction loss and apical constriction are the main drivers of this process.
authors.affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, England, UK kroeper@mrc-lmb.cam.ac.uk.
authors.forename: Clara
authors.identifier: 0000-0002-2125-8858
authors.initials: C
authors.lastname: Sidor
authors.affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, England, UK kroeper@mrc-lmb.cam.ac.uk.
authors.forename: Katja
authors.identifier: 0000-0002-3361-766X
authors.initials: K
authors.lastname: Röper
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D004331:Drosophila melanogaster / Q000166:cytology*; D009218:Myosins; D058953:Neural Stem Cells / Q000166:cytology*
chemical_list: D009218:Myosins