title: The Effect of Immunologically Safe Plasma Rich in Growth Factor Eye Drops in Patients with Sjögren Syndrome.
abstract: The objective was to provide preliminary information about the efficacy and safety of immunologically safe plasma rich in growth factor (immunosafe PRGF) eye drops in the treatment of moderate to severe dry eye in patients with primary and secondary Sjögren's syndrome (SS) and to analyze the influence of several variables on treatment outcomes.
  
  
  
  This retrospective study included patients with SS. All patients were treated with previously immunosafe PRGF eye drops to reduce the immunologic component contents. Ocular Surface Disease Index (OSDI) scale, best-corrected visual acuity (BCVA), visual analog scale (VAS) frequency, and VAS severity outcome measures were evaluated before and after treatment with immunosafe PRGF. The potential influence of some patient clinical variables on results was also assessed. Safety assessment was also performed reporting all adverse events.
  
  
  
  Twenty-six patients (12 patients with primary SS, and 14 patients suffering secondary SS) with a total of 52 affected eyes were included and evaluated. Immunosafe PRGF treatment showed a significant reduction (P < 0.05) in OSDI scale (41.86%), in BCVA (62.97%), in VAS frequency (34.75%), and in VAS severity (41.50%). BCVA and VAS frequency scores improved significantly (P < 0.05) after concomitant treatment of PRGF with corticosteroids. Only 2 adverse events were reported in 2 patients (7.7% of patients).
  
  
  
  Signs and symptoms of dry eye syndrome in patients with SS were reduced after treatment with PRGF-Endoret eye drops. Immunosafe PRGF-Endoret is safe and effective for treating patients with primary and secondary SS.
authors.affiliation: 1 Instituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universdiad de Oviedo, Oviedo, Spain .
authors.forename: Ronald Mauricio
authors.initials: RM
authors.lastname: Sanchez-Avila
authors.affiliation: 1 Instituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universdiad de Oviedo, Oviedo, Spain .
authors.forename: Jesus
authors.initials: J
authors.lastname: Merayo-Lloves
authors.affiliation: 1 Instituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universdiad de Oviedo, Oviedo, Spain .
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Riestra
authors.affiliation: 2 Fundación Eduardo Anitua, Vitoria, Spain .|3 Biotechnology Institute (BTI) , Vitoria, Spain .
authors.forename: Eduardo
authors.initials: E
authors.lastname: Anitua
authors.affiliation: 2 Fundación Eduardo Anitua, Vitoria, Spain .|3 Biotechnology Institute (BTI) , Vitoria, Spain .
authors.forename: Francisco
authors.initials: F
authors.lastname: Muruzabal
authors.affiliation: 3 Biotechnology Institute (BTI) , Vitoria, Spain .|4 NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country , School of Pharmacy, Vitoria, Spain .|5 Biomedical Research Networking Center in Bioengineering , Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain .
authors.forename: Gorka
authors.initials: G
authors.lastname: Orive
authors.affiliation: 1 Instituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universdiad de Oviedo, Oviedo, Spain .
authors.forename: Luis
authors.initials: L
authors.lastname: Fernández-Vega
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009883:Ophthalmic Solutions
keywords: PRP; Sjögren syndrome; dry eye; plasma rich in growth factors; platelet-rich plasma