title: Neurological Complications and Sequelae of Ebola Virus Disease.
abstract: OBJECTIVE
  The recent 2014-2016 outbreak of Ebola virus disease (EVD) has led to many discoveries regarding Ebola. Although neurological symptoms during EVD had been previously described, many reports since this outbreak have made clear that EVD can lead to neurological issues. This article will review the various neurological manifestations of EVD.
  
  
  RESULTS
  Recently, many neurological symptoms have been described during acute EVD, including altered mental status, seizures, and meningoencephalitis, among others; survivors of EVD also may develop neurological sequelae, such as persistent headache and memory loss and can exhibit abnormalities on neurological exam. Additionally, it is now evident that in rare cases, survivors may experience relapses of EVD months after recovery, including the central nervous system (CNS). EVD can result in many clinical neurological manifestations, both acutely and after recovery. Research is ongoing to further clarify the nature of Ebola in the CNS.
authors.affiliation: National Institutes of Neurological Diseases and Stroke National Institutes of Health, 10 Center Drive, Room 5C-103, Bethesda, MD, 20892, USA. Bridgette.billioux@nih.gov.
authors.forename: Bridgette Jeanne
authors.initials: BJ
authors.lastname: Billioux
keywords: Ebola virus disease; Neurological sequelae; Viral persistence