title: Breath-hold and free-breathing 2D phase-contrast MRI for quantification of oxygen-induced changes of pulmonary circulation dynamics in healthy volunteers.
abstract: To evaluate the effect of inhaled 100% oxygen on pulmonary circulation dynamics in healthy volunteers using 2D phase-contrast magnetic resonance imaging (2D PC MRI).
  
  
  
  Twenty-one healthy volunteers were examined at 1.5T. Through-plane 2D PC MRI measurements were performed in the main pulmonary artery during free-breathing and breath-hold. Acceleration time and volume, maximum and minimum area, area change, average and maximum mean velocity, forward volume, heart rate, as well as blood pressure were determined. At baseline, subjects breathed room air. After application of a closed-fit full face mask, three further measurements were conducted: at room air (control), directly after starting 15 L/min 100% oxygen (wash-in), and after 5 minutes during continuous oxygen supply (saturation). Data were analyzed with a mixed linear model. Skewed distributed variables were rank-transformed. Tukey contrasts with family-wise adjusted P-values were applied for pairwise comparisons.
  
  
  
  Inhaled oxygen affected several hemodynamic parameters. Average mean velocity (P < 0.01: breath-hold during wash-in and saturation, P = 0.03: free-breathing during saturation) and maximum mean velocity (P < 0.01: breath-hold and free-breathing during saturation) decreased. When obtained during free-breathing, acceleration volume (P = 0.02: saturation), area change (P = 0.02: saturation), and maximum area (P = 0.02: wash-in, P = 0.03: saturation) increased, while minimum area and forward volume did not change.
  
  
  
  Oxygen alters pulmonary circulation dynamics in the main pulmonary artery of healthy volunteers, which can be reliably detected using 2D phase-contrast MRI.
  
  
  
  2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2017;46:1698-1706.
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.|Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany.
authors.forename: Christoph P
authors.initials: CP
authors.lastname: Czerner
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.|Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany.
authors.forename: Hinrich B
authors.initials: HB
authors.lastname: Winther
authors.affiliation: Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.
authors.forename: Antonia
authors.initials: A
authors.lastname: Zapf
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.|Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Wacker
authors.affiliation: Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.|Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Vogel-Claussen
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D062485:Breath Holding; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008168:Lung / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage*; D011446:Prospective Studies; D011652:Pulmonary Circulation / Q000502:physiology*; D012016:Reference Values; D012119:Respiration
chemical_list: D010100:Oxygen
keywords: 2D PC MRI; oxygen; pulmonary artery; pulmonary vasoreactivity