title: Lethal Congenital Malformations in Fetuses-Antenatal Ultrasound or Perinatal Autopsy.
abstract: BACKGROUND
  Congenital malformations (CMF) are major causes of fetal demise which can be detected antenatally by Ultrasonography (USG).
  
  
  METHODS
  We studied 100 perinatal autopsies for CMF. Sensitivity of USG was determined and accuracy of USG with that of autopsy was compared.
  
  
  RESULTS
  At Autopsy 134 individual CMF were seen in 40 cases. The sensitivity of USG in detecting major CMF was 54.47%. A complete agreement between autopsy and USG findings was seen in 13/40 (32.5%) and partial agreement in 17/40 (42.5%) fetuses while autopsy completely changed antenatal diagnosis in 10/40 (25%) fetuses. Major findings were added in all 17 fetuses with partial agreement. In 2 cases, CMF suspected on USG were not detected on autopsy due to fetal maceration.
  
  
  CONCLUSIONS
  Autopsy significantly adds to the prenatal USG diagnosis and may help in predicting the probability of recurrence, and thus counseling the affected couple to prevent any such future event.
authors.affiliation: a Department of Pathology , Dayanand Medical College and Hospital , Tagore Nagar, Ludhiana , India.
authors.forename: Sumit
authors.identifier: http://orcid.org/0000-0002-2315-6097
authors.initials: S
authors.lastname: Grover
authors.affiliation: a Department of Pathology , Dayanand Medical College and Hospital , Tagore Nagar, Ludhiana , India.
authors.forename: Bhavna
authors.initials: B
authors.lastname: Garg
authors.affiliation: a Department of Pathology , Dayanand Medical College and Hospital , Tagore Nagar, Ludhiana , India.
authors.forename: Neena
authors.initials: N
authors.lastname: Sood
authors.affiliation: b Department of Neonatology , Dayanand Medical College and Hospital , Tagore Nagar, Ludhiana , India.
authors.forename: Kamaldeep
authors.initials: K
authors.lastname: Arora
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000000981:diagnostic imaging; D001344:Autopsy; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D007194:India; D011247:Pregnancy; D050497:Stillbirth; D016216:Ultrasonography, Prenatal
keywords: Antenatal ultrasound; congenital malformation; correlation; perinatal autopsy