title: Relationship between Occupational Stress, 5-HT2A Receptor Polymorphisms and Mental Health in Petroleum Workers in the Xinjiang Arid Desert: A Cross-Sectional Study.
abstract: At present, there is growing interest in research examining the relationship between occupational stress and mental health. Owing to the socioeconomic impact of occupational stress and the unique environment of petroleum workers in Xinjiang, a cross-sectional study was carried out between April and December 2015 to investigate the relationship between occupational stress, 5-hydroxytryptamine receptor (5-HTR2A) genotype, and mental health. A total of 1485 workers were selected. The Symptom Checklist 90 was used to assess nine classes of psychological symptoms. Work-related stressors were evaluated using the Occupational Stress Inventory-Revised Edition. Levels of 5-HTR2A (the Tl02C and A-1438G single nucleotide polymorphism in the 5-HTR2A gene) were measured by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The findings of the present study revealed a high prevalence rate of mental health problems (40.29%) in petroleum workers stationed in the arid desert, and suggested a strong correlation between occupational stress and mental health. The TC and CC genotype of Tl02C were found to be protective factors against mental health problems (odds ratio (OR) = 0.455, 95% confidence interval (CI): = 0.269-0.771, odds ratio (OR) = 0.340, 95% confidence interval (CI): 0.162-0.716). AG and GG genotype of A-1438G [odds ratio (OR) 1 = 2.729, 95% confidence interval (CI): 1.433-5.195; odds ratio (OR) 2 = 2.480, 95% confidence interval (CI): 1.221-5.037] were revealed as risk factors. These data provide evidence that occupational stress and 5-HTR2A gene polymorphism contributes to the incidence of mental health problems.
authors.affiliation: Department of Public Health, Xinjiang Medical University, Urumqi 830011, China. jt5583@126.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Public Health, Xinjiang Medical University, Urumqi 830011, China. gehua2710@sina.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Ge
authors.affiliation: The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China. sjt3997@163.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Public Health, Xinjiang Medical University, Urumqi 830011, China. lurong_128@126.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832008, China. shihaohua789@163.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Han
authors.affiliation: Department of Public Health, Xinjiang Medical University, Urumqi 830011, China. liujiwen@xjmu.edu.cn.
authors.forename: Jiwen
authors.initials: J
authors.lastname: Liu
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D016272:Occupational Health; D000066388:Oil and Gas Industry; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012307:Risk Factors; D013315:Stress, Psychological
chemical_list: D044402:Receptor, Serotonin, 5-HT2A
keywords: 5-HT2RA; mental health; occupational stress; petroleum workers