title: CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis.
abstract: We conducted a meta-analysis to investigate the controversial association of CD147 expression with HCC prognosis and clinicopathological characteristics. Eight studies from PubMed (1966-2016), EMBASE (1980-2016), Cochrane Library (1996-2016), Web of Science (1945-2016), China National Knowledge Infrastructure (1982-2016), and Wanfang databases (1988-2016) were considered. The associations between CD147 expression and clinicopathological parameters and overall survival (OS) or DFS/RFS were reassessed using the meta-analysis for odds ratio (OR) or hazard ratio (HR) and 95% confidence interval (CI). CD147 expression was associated with DFS/RFS (HR = 3.26; 95% CI: 1.82-5.83;P< 0.0001) but not with OS (HR = 1.35; 95% CI: 0.56-3.29;P= 0.51). We also delved deeper into the association between median survival time and CD147 expression owing to significant heterogeneity and found significant differences between high and low CD147 expression groups with respect to median survival time. CD147 expression was closely associated with the TNM stage (OR = 0.18; 95% CI: 0.04-0.85;P= 0.03) and venous invasion (OR = 6.29; 95% CI: 1.70-23.20;P= 0.006). In contrast, there was no association between CD147 expression and tumor stage, cirrhosis, differentiation, lymph node metastasis, HBsAg, and serum AFP levels. Thus, CD147 expression is potentially closely related to HCC survival and associated clinicopathological parameters, paving the way for further research.
authors.affiliation: Department of Laboratory, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Peng
authors.affiliation: Reproductive Department, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Laboratory, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: You
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, China.
authors.forename: Hongru
authors.initials: H
authors.lastname: Li
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, China.
authors.forename: Dongwen
authors.initials: D
authors.lastname: Wu
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, China.
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Hepatic Surgery Department of Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Guangtong
authors.initials: G
authors.lastname: Deng
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan, China.
authors.forename: Yuyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Laboratory, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan, China.
authors.forename: Yi
authors.identifier: 0000-0002-2515-8942
authors.initials: Y
authors.lastname: Wu
mesh_terms: D051926:Basigin / Q000096:biosynthesis* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D051926:Basigin