title: Bovine serum albumin-glutaraldehyde (BioGlue®) tissue adhesiveversusstandard renorrhaphy following renal mass enucleation: a retrospective comparison.
abstract: BACKGROUND
  To present the operative and post-operative comparison between patients who underwent tumor-bed closure with sutures compared with bovine serum albumin-glutaraldehyde (BioGlue®) tissue sealant only.
  
  
  METHODS
  We retrospectively analyzed data from our ongoing database of 507 eligible patients who underwent open NSS nephron-sparing surgery in our department between January 1995 and May 2014. Patients had tumor-bed closure with sealant adhesive (255 patients) or standard suture technique (252 patients). Demographic, clinical and perioperative data were compared between the two groups, by Chi-square test or by Fisher-Irwin exact test for categorical variables, and byttest for differences in means or by Wilcoxon rank sum test for continuous variables. A multivariate analysis was also done.
  
  
  RESULTS
  Patients' baseline characteristics showed similar distribution of the analyzed parameters among both groups, with few differences: younger age in the sealant group (65.4versus68.4 years,p= 0.01) and slightly larger mass size in the suture group (4.0versus3.9 cm,p= 0.03). Ischemia time was significantly shorter in the sealant group (21.8versus27.0 minutes,p= 0001). Blood loss and transfusion rate (0.8%versus11.9%,p= 0.0001) were significantly less in the sealant group. A multivariate analysis showed date of surgery and blood loss as the major parameters affecting transfusion rate.
  
  
  CONCLUSIONS
  Closing the tumor bed with BioGlue®tissue adhesive is feasible, safe, can shorten ischemia time and potentially reduce transfusion rate.
authors.affiliation: Department of Urology, Bnai-Zion Medical Center, Golomb 47, Haifa, Israel.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Bahouth
authors.affiliation: Department of Urology, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: Boaz
authors.initials: B
authors.lastname: Moskovitz
authors.affiliation: Department of Urology, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: Sarel
authors.initials: S
authors.lastname: Halachmi
authors.affiliation: Department of Urology, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: Ofer
authors.initials: O
authors.lastname: Nativ
keywords: BioGlue®; nephron-sparing surgery; renal cell carcinoma; renorrhaphy; tissue sealant