title: Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging.
abstract: The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques. Tumor stromal density of each tumor was measured using diffusion-weighted imaging and magnetization transfer (MT-MRI). Histologic measurement showed a similar trend with tumor fibrosis levels. Results indicated that MRI measurements can serve as a valuable tool in identifying and evaluating tumor characteristics.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle, Washington.
authors.forename: Navid
authors.initials: N
authors.lastname: Farr
authors.affiliation: Applied Physics Laboratory, University of Washington, Seattle, Washington.
authors.forename: Yak-Nam
authors.initials: YN
authors.lastname: Wang
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington.
authors.forename: Samantha
authors.initials: S
authors.lastname: D'Andrea
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington.
authors.forename: Kayla M
authors.initials: KM
authors.lastname: Gravelle
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington.|Department of Radiology, University of Washington, Seattle, Washington.
authors.forename: Joo Ha
authors.initials: JH
authors.lastname: Hwang
authors.affiliation: Department of Radiology, University of Washington, Seattle, Washington.
authors.forename: Donghoon
authors.identifier: http://orcid.org/0000-0001-5220-3991
authors.initials: D
authors.lastname: Lee
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor
keywords: Apparent diffusion coefficient; KPC mouse model; fibrosis; magnetic resonance imaging; magnetization transfer ratio; pancreatic ductal adenocarcinoma