title: Brazilian Green Propolis Promotes Weight Loss and Reduces Fat Accumulation in C57BL/6 Mice Fed A High-Fat Diet.
abstract: Propolis is a bee product with various biological properties. C57BL/6 mice were fed a high-fat diet and treated with propolis for 14 weeks. Body weight in mice treated with 2% propolis was less than that in control mice from 3 weeks after the start of treatment until 14 weeks except for the 7th week. Mice treated with propolis showed significantly lower epididymal fat weight and subcutaneous fat weight. Infiltration of epididymal fat by macrophages and T cells was reduced in the propolis group. Supplementation of propolis increased feces weight and fat content in feces, suggesting that mechanisms of weight reduction by propolis partly include a laxative effect and inhibition of fat absorption.
authors.affiliation: Department of Public Health and Applied Nutrition, Institute of Biomedical Science, Tokushima University of Graduate School.
authors.forename: Tohru
authors.initials: T
authors.lastname: Sakai
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ohhata
authors.forename: Misaki
authors.initials: M
authors.lastname: Fujii
authors.forename: Sayaka
authors.initials: S
authors.lastname: Oda
authors.forename: Yasuna
authors.initials: Y
authors.lastname: Kusaka
authors.forename: Miki
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakamoto
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Taki
authors.forename: Mariko
authors.initials: M
authors.lastname: Nakamoto
authors.forename: Emi
authors.initials: E
authors.lastname: Shuto
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011429:Propolis / Q000494:pharmacology*; D014280:Triglycerides / Q000037:antagonists & inhibitors / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects* / Q000502:physiology*
chemical_list: D014280:Triglycerides; D011429:Propolis; D002784:Cholesterol