title: Synthesis of AHMOD-containing aminolipopeptides, unique bioactive peptaibiotics.
abstract: An interesting family of bioactive aminolipopeptides contain the unusual building block 2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid (AHMOD). This building block has presented a significant challenge to synthesis of this family of aminolipopeptides due to the sensitive β-hydroxyketone motif present. The discovery and identification, syntheses, and eventual incorporation of synthetically challenging AHMOD into selected aminolipopeptides is described herein.
authors.affiliation: School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, New Zealand. m.brimble@auckland.ac.nz.
authors.forename: Louise A
authors.initials: LA
authors.lastname: Stubbing
authors.forename: Iman
authors.initials: I
authors.lastname: Kavianinia
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003652:Decanoic Acids / Q000737:chemistry; D055666:Lipopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: C000626889:2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid; D000900:Anti-Bacterial Agents; D003652:Decanoic Acids; D055666:Lipopeptides