title: Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines.
abstract: Copper triflate-BOX complexes catalyse the enantioselective conjugate addition of methyl malonate to β-trifluoromethyl-α,β-unsaturated imines to give the corresponding enamines bearing a trifluoromethylated stereogenic centre with good yields, and diastereo- and enantioselectivities. The usefulness of the method has been shown with the synthesis of optically active β-trifluoromethyl δ-amino esters and optically active trifluoromethyl piperidones.
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Universitat de València, C/ Dr. Moliner 50, 46100-Burjassot, Spain. jose.r.pedro@uv.es gonzalo.blay@uv.es.
authors.forename: Miguel
authors.initials: M
authors.lastname: Espinosa
authors.forename: Jorge
authors.initials: J
authors.lastname: Herrera
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Blay
authors.forename: Luz
authors.initials: L
authors.lastname: Cardona
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Muñoz
authors.forename: José R
authors.initials: JR
authors.lastname: Pedro