title: Safety and Patient Satisfaction of AbobotulinumtoxinA for Aesthetic Use: A Systematic Review.
abstract: A systematic review of the published literature (from January 2000 to January 2016) to ascertain the safety of, and patient satisfaction with, the aesthetic use of abobotulinumtoxinA was conducted. In addition to the licensed indications, other special populations were considered for discussion. The potential impact of neutralizing antibodies and systemic toxicity were also addressed. A total of 364 papers were screened and 86 were found to be relevant to the population, intervention(s), and outcomes stipulated in the protocol. The safety and patient satisfaction data from these publications are discussed in this review.
authors.affiliation: Associate Clinical Professor, Department of Dermatology, University of Colorado, Boulder, CO, USA.|Assistant Clinical Professor, Department of Dermatology, University of California Irvine, Irvine, CA, USA.
authors.forename: Joel L
authors.initials: JL
authors.lastname: Cohen
authors.affiliation: Full Professor of Plastic and Reconstructive Surgery, Department of Surgery, Sapienza University of Rome, Rome, Italy.
authors.forename: Nicolo
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D017439:Cicatrix, Hypertrophic / Q000628:therapy; D002986:Clinical Trials as Topic; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005152:Facial Muscles / Q000187:drug effects; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D007627:Keloid / Q000188:drug therapy; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D017060:Patient Satisfaction; D011247:Pregnancy / Q000187:drug effects; D015595:Skin Aging / Q000187:drug effects*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D057134:Antibodies, Neutralizing; D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA