title: Molecular Pathways: Metabolic Control of Histone Methylation and Gene Expression in Cancer.
abstract: Epigenetic alterations contribute to tumor development, progression, and therapeutic response. Many epigenetic enzymes use metabolic intermediates as cofactors to modify chromatin structure. Emerging evidence suggests that fluctuation in metabolite levels may regulate activities of these chromatin-modifying enzymes. Here, we summarize recent progress in understanding the cross-talk between metabolism and epigenetic control of gene expression in cancer. We focus on how metabolic changes, due to diet, genetic mutations, or tumor microenvironment, regulate histone methylation status and, consequently, affect gene expression profiles to promote tumorigenesis. Importantly, we also suggest some potential therapeutic approaches to target the oncogenic role of metabolic alterations and epigenetic modifications in cancer.Clin Cancer Res; 23(15); 4004-9. ©2017 AACR.
authors.affiliation: Department of Cancer Biology, Beckman Research Institute of City of Hope Cancer Center, Duarte, California.
authors.forename: Thai Q
authors.initials: TQ
authors.lastname: Tran
authors.affiliation: Department of Cancer Biology, Beckman Research Institute of City of Hope Cancer Center, Duarte, California.
authors.forename: Xazmin H
authors.initials: XH
authors.lastname: Lowman
authors.affiliation: Department of Cancer Biology, Beckman Research Institute of City of Hope Cancer Center, Duarte, California. mekong@coh.org.
authors.forename: Mei
authors.initials: M
authors.lastname: Kong
mesh_terms: D000107:Acetylation; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002843:Chromatin / Q000235:genetics; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008745:Methylation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D002843:Chromatin; D006657:Histones