title: Neural Reorganization Due to Neonatal Amygdala Lesions in the Rhesus Monkey: Changes in Morphology and Network Structure.
abstract: It is generally believed that neural damage that occurs early in development is associated with greater adaptive capacity relative to similar damage in an older individual. However, few studies have surveyed whole brain changes following early focal damage. In this report, we employed multimodal magnetic resonance imaging analyses of adult rhesus macaque monkeys who had previously undergone bilateral, neurotoxic lesions of the amygdala at about 2 weeks of age. A deformation-based morphometric approach demonstrated reduction of the volumes of the anterior temporal lobe, anterior commissure, basal ganglia, and pulvinar in animals with early amygdala lesions compared to controls. In contrast, animals with early amygdala lesions had an enlarged cingulate cortex, medial superior frontal gyrus, and medial parietal cortex. Diffusion-weighted imaging tractography and network analysis were also used to compare connectivity patterns and higher-level measures of communication across the brain. Using the communicability metric, which integrates direct and indirect paths between regions, lesioned animals showed extensive degradation of network integrity in the temporal and orbitofrontal cortices. This work demonstrates both degenerative as well as progressive large-scale neural changes following long-term recovery from neonatal focal brain damage.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA 95817, USA.|The MIND Institute, University of California Davis, Sacramento, CA 95817, USA.|Center for Neuroscience, University of California Davis, Davis, CA 95618, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Grayson
authors.affiliation: Department of Psychology, University of California Davis, Davis, CA 95616, USA.|California National Primate Research Center, Davis, CA 95616, USA.
authors.forename: E
authors.initials: E
authors.lastname: Bliss-Moreau
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA 95817, USA.|The MIND Institute, University of California Davis, Sacramento, CA 95817, USA.|California National Primate Research Center, Davis, CA 95616, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bennett
authors.affiliation: Laboratory of Brain and Cognitive Development, Department of Medicine, Fribourg Center for Cognition, University of Fribourg, 1700 Fribourg, Switzerland.|Laboratory for Experimental Research on Behavior, Institute of Psychology, University of Lausanne, 1015 Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Lavenex
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of California Davis, Sacramento, CA 95817, USA.|The MIND Institute, University of California Davis, Sacramento, CA 95817, USA.|Center for Neuroscience, University of California Davis, Davis, CA 95618, USA.|California National Primate Research Center, Davis, CA 95616, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Amaral
mesh_terms: D000679:Amygdala / Q000000981:diagnostic imaging / Q000473:pathology*; D000818:Animals; D000831:Animals, Newborn; D001930:Brain Injuries / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D063132:Connectome; D038524:Diffusion Magnetic Resonance Imaging; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D005260:Female; D007051:Ibotenic Acid / Q000633:toxicity; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008253:Macaca mulatta; D008297:Male; D009434:Neural Pathways / Q000502:physiology*
chemical_list: D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid
keywords: brain damage; connectome; morphometry; plasticity; tractography