title: Relationship of High-Sensitivity C-Reactive Protein Concentrations and Systolic Heart Failure.
abstract: OBJECTIVE
  Excessive activated proinflammatory cytokines may promote extracellular matrix alterations which induce adverse left ventricular remodeling in systolic heart failure (SHF). We sought to identify whether high-sensitivity C-reactive protein (hsCRP) levels were independently associated with SHF.
  
  
  METHODS
  In our retrospective case-control study, 2236 subjects were included, and 260 patients had SHF. Blood sample collection, clinical laboratory tests, electrocardiogram and echocardiography examinations were performed. The questionnaires were completed by professional interviews.
  
  
  RESULTS
  In 2236 subjects, the prevalence rate of SHF were 1.7, 1.8, 8.4 and 32.6% between hsCRP concentrations (<1 mg/L, ≥1 to <3 mg/L, ≥3 to <10 mg/L and ≥10 mg/L, respectively) (p=0.000). hsCRP concentrations (<1 mg/L, ≥1 to <3 mg/L, ≥3 to <10 mg/L and ≥10 mg/L) were associated in a linear trend with N-terminal pro-brain natriuretic peptide (NT-proBNP, p=0.000) and left ventricular ejection fraction (LVEF, p=0.000). hsCRP was also significantly related to NT-proBNP, LVEF and SHF (r=0.232, p=0.000; r=-0.358, p=0.000 and r=0.413, p=0.000, respectively). In logistic regression model, after adjusting for heart failure risk factors, compared with the low concentration of hsCRP (<1 mg/L), the high concentration of hsCRP (≥10 mg/L) was significantly independently associated with SHF (odds ratio = 10.78 [1.303 to 89.10], p=0.027).
  
  
  CONCLUSIONS
  Low to high concentration of hsCRP showed a linear trend association with SHF. A high concentration of hsCRP was independently associated with SHF.
authors.affiliation: Center of Cardiology, Shanghai East Hospital, Tongji University, Jimo Rd 150, 200120, Shanghai, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Clinical Laboratory, Shanghai East Hospital, Tongji University, Shanghai, China.
authors.forename: Lie-Ying
authors.initials: LY
authors.lastname: Fan
authors.affiliation: Department of Cardiac Ultrasound, Shanghai East Hospital, Tongji University, Shanghai, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, Tongji University School of Medical, Shanghai, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Li
authors.affiliation: Center of Cardiology, Shanghai East Hospital, Tongji University, Shanghai, China.
authors.forename: Zhong-Min
authors.initials: ZM
authors.lastname: Liu
mesh_terms: D000368:Aged; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D054143:Heart Failure, Systolic / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein; D002784:Cholesterol
keywords: High-sensitivity C-reactive protein; fasting blood sugar; systolic heart failure; total cholesterol