title: Polyphenol-Inspired Facile Construction of Smart Assemblies for ATP- and pH-Responsive Tumor MR/Optical Imaging and Photothermal Therapy.
abstract: Smart assemblies have attracted increased interest in various areas, especially in developing novel stimuli-responsive theranostics. Herein, commercially available, natural tannic acid (TA) and iron oxide nanoparticles (Fe3O4NPs) are utilized as models to construct smart magnetic assemblies based on polyphenol-inspired NPs-phenolic self-assembly between NPs and TA. Interestingly, the magnetic assemblies can be specially disassembled by adenosine triphosphate, which shows a stronger affinity to Fe3O4NPs than that of TA and partly replaces the surface coordinated TA. The disassembly can further be facilitated by the acidic environment hence causing the remarkable change of the transverse relaxivity and potent "turn-on" of fluorescence (FL) signals. Therefore, the assemblies for specific and sensitive tumor magnetic resonance and FL dual-modal imaging and photothermal therapy after intravenous injection of the assemblies are successfully employed. This work not only provides understandings on the self-assembly between NPs and polyphenols, but also will open new insights for facilely constructing versatile assemblies and extending their biomedical applications.
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Song
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
authors.forename: Shi-Hua
authors.initials: SH
authors.lastname: Li
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
authors.forename: Jiayong
authors.initials: J
authors.lastname: Dai
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Song
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
authors.forename: Guoming
authors.initials: G
authors.lastname: Huang
authors.affiliation: Academy of Intergrative Medicine, Biomedical Research Center, Fujian University of Tranditional Chinese Medicine, Fuzhou, 350122, China.
authors.forename: Ruhui
authors.initials: R
authors.lastname: Lin
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostic, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361005, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry*; D000818:Animals; D000067493:Dynamic Light Scattering; D005453:Fluorescence; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D008279:Magnetic Resonance Imaging; D051379:Mice; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D061848:Optical Imaging; D010789:Phototherapy; D059808:Polyphenols / Q000502:physiology*; D012996:Solutions
chemical_list: D059808:Polyphenols; D012996:Solutions; D000255:Adenosine Triphosphate
keywords: fluorescence; magnetic properties; photothermal therapy; self-assembly; stimuli-responsive