title: Retinal microvascular alterations related to diabetes assessed by optical coherence tomography angiography: A cross-sectional analysis.
abstract: Fluorescein angiography has been so far the gold-standard test to assess diabetic macular ischemia (DMI), a cause of irreversible visual impairment in diabetic patients. The aim of this study was to investigate foveal avascular zone (FAZ) and perifoveal microcirculation changes in eyes with nonproliferative diabetic retinopathy (NPDR) using optical coherence tomography angiography (OCTA), a new and noninvasive vascular imaging technique.Cross-sectional study including eyes of diabetic patients with NPDR.All patients underwent medical history, best-corrected visual acuity (BCVA) measurement, slit-lamp and fundus examination, multicolor imaging, SD-OCT, and swept-source OCT. OCTA was performed in order to assess macular superficial and deep capillary plexus, and swept-source OCT was performed to evaluate the central choroidal thickness.Fifty-eight eyes of 35 patients with a mean age of 61.8 years (±12.1) with mean HbA1C level of 7.6% (±1.5) were included in this study. Among them, 19 eyes had mild NPDR, 24 eyes had moderate NPDR, and 15 eyes had severe NPDR. There was a significant progression between NPDR stages for FAZ grade (P < 0.0001), surface (P = 0.0036) and perimeter (P = 0.0001), and for superficial capillary plexus nonperfusion index (NPI) (P = 0.0009). Moreover, a significant correlation was found between NPI and BCVA (P = 0.007).OCT angiography is a useful noninvasive tool to explore early phases of diabetic retinopathy, which are not routinely explore with fluorescein angiography and not precisely enough with color photographs. NPI and foveal avascular zone parameters are correlated with glycated hemoglobin in patients with NPDR. If confirmed by further studies, these results could represent a mean to sensibilize diabetic patients to their disease.
authors.affiliation: Department of Ophthalmology, CHU Poitiers Public Health Department, University of Poitiers University of Poitiers, UFR de Médecine et Pharmacie Biostatistics, INSERM CIC 1402, Centre d'investigation clinique, University Hospital of Poitiers Diabetology Department, Poitiers - Coordinating Center of the DIAB2NEPHROGENE Study INSERM 1084, University of Poitiers, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Gozlan
authors.forename: Pierre
authors.initials: P
authors.lastname: Ingrand
authors.forename: Olivier
authors.initials: O
authors.lastname: Lichtwitz
authors.forename: Agathe
authors.initials: A
authors.lastname: Cazet-Supervielle
authors.forename: Léa
authors.initials: L
authors.lastname: Benoudis
authors.forename: Michele
authors.initials: M
authors.lastname: Boissonnot
authors.forename: Samy
authors.initials: S
authors.lastname: Hadjadj
authors.forename: Nicolas
authors.initials: N
authors.lastname: Leveziel
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005584:Fovea Centralis / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D012171:Retinal Vessels / Q000000981:diagnostic imaging / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity