title: Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy.
abstract: Diffuse optical spectroscopic imaging (DOSI) and diffuse correlation spectroscopy (DCS) are model-based near-infrared (NIR) methods that measure tissue optical properties (broadband absorption, ? a , and reduced scattering, ? s ? ) and blood flow (blood flow index, BFI), respectively. DOSI-derived ? a values are used to determine composition by calculating the tissue concentration of oxy- and deoxyhemoglobin ( HbO 2 , HbR), water, and lipid. We developed and evaluated a combined, coregistered DOSI/DCS handheld probe for mapping and imaging these parameters. We show that uncertainties of 0.3 ?? mm ? 1 (37%) in ? s ? and 0.003 ?? mm ? 1 (33%) in ? a lead to ? 53 % and 9% errors in BFI, respectively. DOSI/DCS imaging of a solid tissue-simulating flow phantom and
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Hossein S
authors.initials: HS
authors.lastname: Yazdi
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: O'Sullivan
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Anais
authors.initials: A
authors.lastname: Leproux
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Brian
authors.initials: B
authors.lastname: Hill
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Amanda
authors.initials: A
authors.lastname: Durkin
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Seraphim
authors.initials: S
authors.lastname: Telep
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Jesse
authors.initials: J
authors.lastname: Lam
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Siavash S
authors.initials: SS
authors.lastname: Yazdi
authors.affiliation: University of California, Chao Family Comprehensive Cancer Center, Orange, California, United States.
authors.forename: Alice M
authors.initials: AM
authors.lastname: Police
authors.affiliation: University of California, Chao Family Comprehensive Cancer Center, Orange, California, United States.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Carroll
authors.affiliation: University of California, Chao Family Comprehensive Cancer Center, Orange, California, United States.
authors.forename: Freddie J
authors.initials: FJ
authors.lastname: Combs
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United StatescLinköping University, Department of Biomedical Engineering, Linköping, Sweden.
authors.forename: Tomas
authors.initials: T
authors.lastname: Strömberg
authors.affiliation: University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania, United States.
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
authors.affiliation: University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Tromberg
mesh_terms: D000328:Adult; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D004058:Diffusion; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008962:Models, Theoretical; D020360:Neoadjuvant Therapy; D010108:Oxyhemoglobins / Q000032:analysis; D019047:Phantoms, Imaging; D013053:Spectrophotometry / Q000379:methods*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D006454:Hemoglobins; D008055:Lipids; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin