title: Iron(II)porphyrin-Cyclodextrin Supramolecular Complex as a Carbon Monoxide-Depleting Agent in Living Organisms.
abstract: The specific intermolecular interaction between an anionic tetraarylporphyrin and per-O-methylated β-cyclodextrin (TMe-β-CD) paved the way to produce a functional supramolecule that works as a strong carbon monoxide (CO)-depleting agent in living organisms. The supramolecular complex, hemoCD, that is composed of meso-tetrakis(4-sulfonatophenyl)porphinatoiron(II) and a TMe-β-CD dimer linked by a pyridine linker, captured internal CO from carboxyhemoglobin during its circulation in the blood of animals. HemoCD thus produced the pseudo-knockdown (loss-of-functional) state of endogenous CO in the animals. This unique property led us to investigate the biological function of endogenous CO as a gaseous signal mediator in living systems. In this paper, we introduce our recent study on the hemoCD complex as a biological CO-depleting agent.
authors.affiliation: Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kitagishi
authors.forename: Saika
authors.initials: S
authors.lastname: Minegishi
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000737:chemistry / Q000378:metabolism*; D003505:Cyclodextrins / Q000737:chemistry / Q000378:metabolism*; D005296:Ferrous Compounds / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D008665:Metalloporphyrins / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure
chemical_list: D003505:Cyclodextrins; D005296:Ferrous Compounds; D046911:Macromolecular Substances; D008665:Metalloporphyrins; D002248:Carbon Monoxide