title: Shining the Light on Senescence Associated LncRNAs.
abstract: Cellular senescence can be described as a complex stress response that leads to irreversible cell cycle arrest. This process was originally described as an event that primary cells go through after many passages of cells during cell culture. More recently, cellular senescence is viewed as a programmed process by which the cell displays a senescence phenotype when exposed to a variety of stresses. Cellular senescence has been implicated in tumor suppression and aging such that senescence may contribute to both tumor progression and normal tissue repair. Here, we review different forms of cellular senescence, as well as current biomarkers used to identify senescent cellsin vitroandin vivo. Additionally, we highlight the role of senescence-associated long noncoding RNAs (lncRNAs).
authors.affiliation: 1CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.; 2Collage of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
authors.forename: A R
authors.initials: AR
authors.lastname: Ghanam
authors.affiliation: 1CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Qianlan
authors.initials: Q
authors.lastname: Xu
authors.affiliation: 1CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Shengwei
authors.initials: S
authors.lastname: Ke
authors.affiliation: 1CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Azhar
authors.affiliation: 1CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: 1CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Song
keywords: biomarkers; cellular senescence; lncRNAs