title: "Life-Steps" for PrEP Adherence: Demonstration of a CBT-Based Intervention to Increase Adherence to Preexposure Prophylaxis (PrEP) Medication Among Sexual-Minority Men at High Risk for HIV Acquisition.
abstract: One dramatic advance in human immunodeficiency virus (HIV) prevention efforts has been the prescription of medications typically used for HIV treatment as prophylaxis against acquiring HIV. As a preventative agent, this practice is referred to as "preexposure prophylaxis" (PrEP). The U.S. Federal Drug Administration approved daily PrEP for adults at risk for HIV who do not consistently use condoms during sex with HIV-infected or unknown-status partners. In this paper, we describe a cognitive-behavioral therapy (CBT) PrEP adherence intervention developed for use in high-risk sexual-minority men in the United States, adapted from "Life-Steps," an evidence-based CBT intervention to promote adherence to HIV treatment. Modules include creating a PrEP dosing schedule, adhering to daily PrEP, problem solving barriers to adherence, and sexual risk-reduction techniques. Supplemented with practical video vignettes, this novel intervention may help to enhance the clinical practice of health care providers in outpatient settings to increase PrEP adherence in sexual-minority men.
authors.affiliation: Wheelock College and Fenway Health.
authors.forename: S Wade
authors.initials: SW
authors.lastname: Taylor
authors.affiliation: Harvard Medical School and Massachusetts General Hospital.
authors.forename: Christina
authors.initials: C
authors.lastname: Psaros
authors.affiliation: Fenway Health and University of Massachusetts Boston.
authors.forename: David W
authors.initials: DW
authors.lastname: Pantalone
authors.affiliation: Fenway Health.
authors.forename: Jake
authors.initials: J
authors.lastname: Tinsley
authors.affiliation: Fenway Health and Thomas Jefferson University, Sidney Kimmel Medical College.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Elsesser
authors.affiliation: Fenway Health and Harvard Medical School and Massachusetts General Hospital.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
authors.affiliation: Fenway Health, Harvard Medical School and Massachusetts General Hospital, and University of Miami.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Safren
keywords: CBT; HIV; MSM; PrEP; medication adherence