title: [Identification of a novel HLA allele HLA-B*46:01:18].
abstract: OBJECTIVE
  To report on a novel human leukocyte antigen (HLA) allele.
  
  
  METHODS
  Polymerase chain reaction-sequence based typing was used for routine HLA typing. For one sample, the result of B locus typing showed mismatch of one base with B*46:01:01, B*15:25:01 at locus 384. The group specific sequencing primers, which target at B*46 and B*15, were used to confirm the difference between the novel allele and the highest homologous allele.
  
  
  RESULTS
  The sequencing results showed that the highest homologous allele to the novel allele was B*46:01:01. The two sequences only differed for position 384 within the exon 3 (384G>T), which resulted in a codon change (GGG>GGT), though the amino acid sequence of the novel allele at position 104 was still Glycine (G). Investigation of the family showed that the novel allele was inherited from the father.
  
  
  CONCLUSIONS
  The novel HLA-B allele, discovered in ethnic Zhuangs from Guangxi, has been designated as HLA-B *46:01:18 by the World Health Organization (WHO) HLA Nomenclature Committee.
authors.affiliation: Nanning Institute of Transfusion Medicine, Nanning, Guangxi 530007, China. shenweidong1960@sohu.com.
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Pei
authors.forename: Huini
authors.initials: H
authors.lastname: Huang
authors.forename: Hengcong
authors.initials: H
authors.lastname: Li
authors.forename: Weidong
authors.initials: W
authors.lastname: Shen
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002681:China; D005091:Exons; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D055815:Young Adult
chemical_list: D015235:HLA-B Antigens