title: New Avermectin Analogues from a Mutant Streptomyces avermectinius Strain.
abstract: Two new avemectin analogues 1 and 2 belonging to 'b' series of components were isolated from a ∆aveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed analysis of NMR and MS spectroscopic data. Compounds 1 and 2 displayed moderate cytotoxicities against B16, MG-63, and Saos-2 cell lines in an in vitro assay.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433, P. R. China.|Department of Naval Health Service and Medical Equipment, Faculty of Medicine, Second Military Medical University, 800 Xiang-Yin Road, Shanghai, 200433, P. R. China.
authors.forename: Youjun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433, P. R. China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433, P. R. China.
authors.forename: Keke
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Naval Health Service and Medical Equipment, Faculty of Medicine, Second Military Medical University, 800 Xiang-Yin Road, Shanghai, 200433, P. R. China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai, 200433, P. R. China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D008546:Melanoma, Experimental / Q000473:pathology; D015394:Molecular Structure; D009154:Mutation; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D007559:Ivermectin; C019264:avermectin
keywords: 
  Streptomyces avermectinius
  ; Avemectin; Cytotoxic activities; Mutant strain; Structural elucidation