title: Bilateral Sertoli Cell Tumors in a Patient with Androgen Insensitivity Syndrome.
abstract: Androgen insensitivity syndrome is the most common cause of male pseudohermaphroditism and the third most common cause of primary amenorrhea. This genetic alteration is a consequence of inherited defects on the X chromosome causing total or partial damage to the intrauterine virilization process due to functional abnormalities in the androgen receptors. The present report describes a 22-year-old patient with a female phenotype and a 46, XY karyotype, presenting with bilateral inguinal tumors. The tumors were surgically removed at theSanta Casa de MisericórdiaHospital in Vitória, Espírito Santo, Brazil. Pathology revealed bilateral testicles with Sertoli cell tumors. According to the international literature, prophylactic gonadectomy following puberty is recommended due to the progressive risk of neoplastic transformation in the residual gonads.
authors.affiliation: Department of Obstetrics and Gynecology, Santa Casa de Misericórdia, Vitória, ES, Brazil.
authors.forename: Roberta Fonseca
authors.identifier: 0000-0002-8126-1450
authors.initials: RF
authors.lastname: de Souza
authors.affiliation: Department of Obstetrics and Gynecology, Santa Casa de Misericórdia, Vitória, ES, Brazil.
authors.forename: Janaina
authors.initials: J
authors.lastname: Pereira da Silva
authors.affiliation: Department of Obstetrics and Gynecology, Santa Casa de Misericórdia, Vitória, ES, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vieira Balla
authors.affiliation: Santa Casa de Misericórdia, Vitória, ES, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Neves Ferreira
authors.affiliation: Department of Obstetrics and Gynecology, Santa Casa de Misericórdia, Vitória, ES, Brazil.
authors.forename: Antônio
authors.initials: A
authors.lastname: Chambô Filho