title: The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics.
abstract: The National Heart, Lung, and Blood Institute's Next Generation Genetic Association Studies Consortium has used induced pluripotent stem cell technology to study the effects of common genetic variants in vitro. This issue of Cell Stem Cell and affiliated journals include several manuscripts describing the results of the consortium's efforts.
authors.affiliation: Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
authors.forename: Curtis R
authors.initials: CR
authors.lastname: Warren
authors.affiliation: National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20824, USA.
authors.forename: Cashell E
authors.initials: CE
authors.lastname: Jaquish
authors.affiliation: Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: chad_cowan@harvard.edu.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Cowan
mesh_terms: D002318:Cardiovascular Diseases / Q000473:pathology; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D005786:Gene Expression Regulation; D014644:Genetic Variation; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D010641:Phenotype
keywords: Community Cohort Study; NHLBI; Next Generation Genetic Association Studies Consortium; cardiovascular disease; genome editing; humanity in a dish; iPSC; polygenic disease; population genetics; quantitative trait locus