title: [Expression and significance of STAT6 in solitary fibrous tumor].
abstract: Objective:To study the clinicopathologic features, the differential diagnosis and the expression of STAT6 in solitary fibrous tumor (SFT).Methods:Eighty cases of SFT were evaluated. The expression of STAT6, CD34, CD99 and bcl-2 protein was studied in these cases and in other groups of soft tissue tumors by immunohistochemical EnVision method. The results were analyzed and relevant literature were reviewed.Results:The expression rate of STAT6 in SFT was 97.5% (78/80) and that in other soft tissue tumors was 3.3% (3/90). The difference was significant (P<0.05). The expression rates of CD34, CD99 and bcl-2 were 88.8% (71/80), 76.3% (61/80) and 75.0% (60/80) in SFT, respectively, which were significantly different from STAT6 expression rate (P<0.05).Conclusions:The expression of STAT6 in SFT has high sensitivity (97.5%) and specificity (96.7%). The expression of STAT6 in SFT is higher than that of CD34, CD99 and bcl-2. STAT6 may be a useful marker for clinical diagnosis of SFT.
authors.affiliation: Department of Pathology, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Ding
authors.forename: Y F
authors.initials: YF
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Rao
mesh_terms: D000071443:12E7 Antigen / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D050800:STAT6 Transcription Factor / Q000378:metabolism*; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D054364:Solitary Fibrous Tumors / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D000071443:12E7 Antigen; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human
keywords: Diagnosis, differential; Immunohistochemistry; STAT6 transcription factor; Solitary fibrous tumors