title: All That Wheezes Is Not Asthma: A Case of Diffuse Large B-Cell Lymphoma of the Larynx.
abstract: Localized laryngeal lymphoma is a rare entity with an incidence of less than 1% of all laryngeal neoplasms. Diffuse large B-cell lymphoma (DLBCL) is the most common type of laryngeal neoplasms. Here, we describe a case of a young 28-year-old female with large B-cell lymphoma who remained undiagnosed for a long time owing to a myriad of nonspecific presentation including "wheezing." Although primary laryngeal lymphomas constitute a diagnostic challenge since they are rare, one should have a high index of suspicion for lymphoma of the larynx in patients presenting with unresolved wheezing as it can present catastrophically with acute airway obstruction requiring immediate surgical intervention which was observed in this case. Treatment includes radiotherapy, chemotherapy, immunotherapy, or a combination of these. We hope that the discussions ensuing from case reports regarding uncommon presentations of laryngeal lymphoma may spur the formation of regional/international databases for the description of lymphomas with unusual presentations. This effort can lead to in-depth study of cases and prompt awareness of "rare and subtle presentations" of laryngeal lymphoma.
authors.affiliation: University of Arizona College of Medicine, Tucson, AZ, USA.
authors.forename: Bushra
authors.identifier: 0000-0003-3453-2497
authors.initials: B
authors.lastname: Rahman
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ, USA.
authors.forename: Jawad
authors.identifier: 0000-0001-7015-8151
authors.initials: J
authors.lastname: Bilal
authors.affiliation: Department of Hematology & Oncology, University of Arizona, Tucson, AZ, USA.
authors.forename: Qurat Ul Ain Riaz
authors.identifier: 0000-0003-4714-3407
authors.initials: QU
authors.lastname: Sipra
authors.affiliation: Department of Medicine, University of Arizona, Tucson, AZ, USA.
authors.forename: Irbaz Bin
authors.identifier: 0000-0003-4249-0311
authors.initials: IB
authors.lastname: Riaz