title: Regional amyloid burden and lacune in pure subcortical vascular cognitive impairment.
abstract: We investigated the amyloid and vascular burden in Pittsburgh compound B (PiB)-negative subcortical vascular mild cognitive impairment (svMCI) and PiB-negative subcortical ischemic vascular dementia (SIVD) to elucidate the potential roles of amyloid deposition and small vessel disease (SVD). Thirty-eight svMCI patients and 42 SIVD patients were enrolled. The regional PiB uptake values and SVD markers were obtained and compared between groups. Additionally, correlations among amyloid burden, SVD, and cognition were made. Patients with PiB-negative SIVD showed more amyloid deposition than those with PiB-negative svMCI, particularly in the cuneus, lingual gyrus, supramarginal, and angular gyri. Despite subthreshold levels for amyloid deposition, our findings showed a marked regional difference in amyloid uptake between svMCI and SIVD, particularly in posteriorly located brain areas. However, lacune, a proxy for vascular burden, showed a broader association with cognition and had more impacts on developing dementia than amyloid burden. The topographical pattern of amyloid deposition and its impact on clinical status in pure subcortical vascular cognitive impairment were different from those in Alzheimer's disease.
authors.affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Yun Jeong
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Department of Biomedical Engineering, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Chan-Mi
authors.initials: CM
authors.lastname: Kim
authors.affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea; Department of Neurology, University of Ulsan College of Medicine, Gangneung Asan Medical Center, Gangneung, Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Kim
authors.affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Jee Hoon
authors.initials: JH
authors.lastname: Roh
authors.affiliation: Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
authors.affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. Electronic address: jhlee@amc.seoul.kr.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D058227:Amyloidogenic Proteins / Q000378:metabolism*; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D059345:Cerebral Small Vessel Diseases / Q000150:complications; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000523:psychology; D015140:Dementia, Vascular / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D013844:Thiazoles; D014057:Tomography, X-Ray Computed
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D058227:Amyloidogenic Proteins; D000814:Aniline Compounds; D013844:Thiazoles
keywords: Amyloid; Cerebral small vessel disease; Pittsburgh compound B; Subcortical ischemic vascular dementia; Subcortical vascular mild cognitive impairment; Vascular cognitive impairment