title: Gray matter volume changes in chronic subcortical stroke: A cross-sectional study.
abstract: This study aimed to investigate the effects of lesion side and degree of motor recovery on gray matter volume (GMV) difference relative to healthy controls in right-handed subcortical stroke. Structural MRI data were collected in 97 patients with chronic subcortical ischemic stroke and 79 healthy controls. Voxel-wise GMV analysis was used to investigate the effects of lesion side and degree of motor recovery on GMV difference in right-handed chronic subcortical stroke patients. Compared with healthy controls, right-lesion patients demonstrated GMV increase (P< 0.05, voxel-wise false discovery rate correction) in the bilateral paracentral lobule (PCL) and supplementary motor area (SMA) and the right middle occipital gyrus (MOG); while left-lesion patients did not exhibit GMV difference under the same threshold. Patients with complete and partial motor recovery showed similar degree of GMV increase in right-lesion patients. However, the motor recovery was correlated with the GMV increase in the bilateral SMA in right-lesion patients. These findings suggest that there exists a lesion-side effect on GMV difference relative to healthy controls in right-handed patients with chronic subcortical stroke. The GMV increase in the SMA may facilitate motor recovery in subcortical stroke patients.
authors.affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Diao
authors.affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Jingchun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
authors.forename: Caihong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Radiology, Tianjin Huanhu Hospital, ,Tianjin 300350,China.
authors.forename: Chen
authors.initials: C
authors.lastname: Cao
authors.affiliation: Department of Radiology, Tianjin Huanhu Hospital, ,Tianjin 300350,China.
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Radiology, Tianjin Huanhu Hospital, ,Tianjin 300350,China.
authors.forename: Tong
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
authors.forename: Jingliang
authors.initials: J
authors.lastname: Cheng
authors.affiliation: School of Medical Imaging, ,Tianjin Medical University, Tianjin 300070, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
mesh_terms: D001931:Brain Mapping; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D066128:Gray Matter / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013223:Statistics as Topic; D020521:Stroke / Q000000981:diagnostic imaging* / Q000473:pathology
keywords: Gray matter volume; Lesion side; Motor recovery; Stroke