title: Mid-Infrared Photothermal Imaging of Active Pharmaceutical Ingredients at Submicrometer Spatial Resolution.
abstract: Chemical imaging with sufficient spatial resolution to resolve microparticles in tablets is essential to ensure high quality and efficacy in controlled release. The existing modalities have the following disadvantages: they are time-consuming or have poor spatial resolution or low chemical specificity. Here, we demonstrate an epi-detected mid-infrared photothermal (epi-MIP) microscope at a spatial resolution of 0.65 μm. Providing identical spectral profiles as conventional infrared spectroscopy, our epi-MIP microscope enabled mapping of both active pharmaceutical ingredients and excipients of a drug tablet.
authors.affiliation: Department of Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.
authors.forename: Chen
authors.identifier: 0000-0002-4391-6196
authors.initials: C
authors.lastname: Li
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University , West Lafayette, Indiana 47907, United States.
authors.forename: Delong
authors.identifier: 0000-0002-9734-3573
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Mechanical Engineering, Purdue University , West Lafayette, Indiana 47907, United States.
authors.forename: Mikhail N
authors.initials: MN
authors.lastname: Slipchenko
authors.affiliation: Department of Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.|Weldon School of Biomedical Engineering, Purdue University , West Lafayette, Indiana 47907, United States.
authors.forename: Ji-Xin
authors.initials: JX
authors.lastname: Cheng
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D005079:Excipients / Q000032:analysis*; D007259:Infrared Rays; D008853:Microscopy / Q000379:methods*; D010316:Particle Size; D013607:Tablets / Q000032:analysis
chemical_list: D005079:Excipients; D013607:Tablets; D000082:Acetaminophen