title: Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila.
abstract: Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.
authors.affiliation: Hubrecht Institute of the KNAW & UMC Utrecht, 3584 CT Utrecht, The Netherlands.
authors.forename: Angelica
authors.initials: A
authors.lastname: Aguilera-Gomez
authors.affiliation: Hubrecht Institute of the KNAW & UMC Utrecht, 3584 CT Utrecht, The Netherlands; Department of Cell Biology, UMC Utrecht, The Netherlands; Department of Cell Biology, UMC Groningen, The Netherlands. Electronic address: c.rabouille@hubrecht.eu.
authors.forename: Catherine
authors.initials: C
authors.lastname: Rabouille
mesh_terms: D000818:Animals; D002451:Cell Compartmentation; D029721:Drosophila Proteins / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D017344:Genes, Insect; D008566:Membranes / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D009865:Oocytes / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D000069816:SEC Translocation Channels / Q000378:metabolism; D016211:Transforming Growth Factor alpha / Q000235:genetics
chemical_list: D029721:Drosophila Proteins; D000069816:SEC Translocation Channels; D016211:Transforming Growth Factor alpha; C083730:grk protein, Drosophila
keywords: COPII; Cell compartmentalization; Drosophila; ER exit sites; FMR1; Liquid droplets; Liquid-liquid phase separation; Low complexity sequence; Membrane-bound organelles; Membrane-less compartments; Oocyte; Orb; PARP16; S2 cells; Sec16; Secretory pathway; Stress granule; gurken translation; mRNA