title: Three new amino acid derivatives from edible mushroom Pleurotus ostreatus.
abstract: Three new amino acid derivatives, oxalamido-L-phenylalanine methyl ester (1), oxalamido-L-leucine methyl ester (2), and lumichrome hydrolyzate (3), together with nine known compounds (4-12), were isolated from the solid culture of edible mushroom Pleurotus ostreatus. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by the chiral synthesis and confirmed by circular dichroism (CD) analysis of their total synthesis products and natural isolates. All new compounds were evaluated for their antioxidant effects, antimicrobial activities, and cytotoxic activity. Compounds 1-3 showed weak antifungal activities against Candida albicans with minimum inhibitory concentration (MIC) value of 500 μg/ml.
authors.affiliation: a Key Laboratory of Structure-Based Drug Design and Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Lu
authors.affiliation: c School of Life Sciences and Biotechnology , Dalian University , Dalian 116622 , China.
authors.forename: Bao-Min
authors.initials: BM
authors.lastname: Feng
authors.affiliation: a Key Laboratory of Structure-Based Drug Design and Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Shao-Fei
authors.initials: SF
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Structure-Based Drug Design and Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.affiliation: a Key Laboratory of Structure-Based Drug Design and Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: a Key Laboratory of Structure-Based Drug Design and Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wang
authors.affiliation: a Key Laboratory of Structure-Based Drug Design and Discovery , Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D005415:Flavins / Q000737:chemistry / Q000302:isolation & purification; D007930:Leucine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020076:Pleurotus / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D005415:Flavins; C000625272:lumichrome hydrolyzate; C000625271:oxalamido-L-leucine methyl ester; C000625270:oxalamido-L-phenylalanine methyl ester; C034515:phenylalanine methyl ester; C030365:leucine methyl ester; D010649:Phenylalanine; D007930:Leucine
keywords: Edible mushroom; Pleurotus ostreatus; antimicrobial activity; antioxidation