title: A new cinnamic acid derivative from plant-derived endophytic fungus Pyronema sp.
abstract: Ten secondary metabolites (1-10) including a new 4-hydroxycinnamic acid derivatives, methyl 2-{(E)-2-[4-(formyloxy)phenyl]ethenyl}-4-methyl-3-oxopentanoate (1), and nine known compounds (2-10) were isolated from an EtOAc extract derived from a solid rice medium of endophytic fungal strain Pyronema sp. (A2-1 & D1-2). Their structures were elucidated from NMR and HRMS data. All the compounds were tested for antibacterial activity against Mycobacterium marinum ATCCBAA-535. Compounds 1, 8 and 9 exhibited moderate antibiotic activity with IC50of 64, 43 and 32 μM, respectively.
authors.affiliation: a Hubei Key Laboratory of Natural Products Research and Development , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.|b Yichang Key Laboratory of Biocatalysis , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.
authors.forename: Zhangshuang
authors.initials: Z
authors.lastname: Deng
authors.affiliation: a Hubei Key Laboratory of Natural Products Research and Development , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Li
authors.affiliation: a Hubei Key Laboratory of Natural Products Research and Development , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
authors.affiliation: c Department of Chemistry , University of South Florida , Tampa , FL , USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Teng
authors.affiliation: a Hubei Key Laboratory of Natural Products Research and Development , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: a Hubei Key Laboratory of Natural Products Research and Development , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Tu
authors.affiliation: a Hubei Key Laboratory of Natural Products Research and Development , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
authors.affiliation: b Yichang Key Laboratory of Biocatalysis , College of Biological and Pharmaceutical Sciences, China Three Gorges University , Yichang , China.
authors.forename: Dachun
authors.initials: D
authors.lastname: Gong
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D002681:China; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology*; D060026:Endophytes / Q000737:chemistry; D015394:Molecular Structure; D019910:Mycobacterium marinum / Q000187:drug effects; D020946:Taxus / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D002934:Cinnamates; C029010:cinnamic acid
keywords: Pyronema sp.; Secondary metabolites; Taxus mairei; cinnamic acid