title: Thyroid Follicular Hyperplasia Associated With Massive Extracellular Mucin Deposition.
abstract: Extensive extracellular mucin deposition is a rare pathological thyroid condition with 6 cases described in literature so far. We report another case of a 67-year-old woman, discussing histopathological features, and review the literature. Our findings showed a diffuse mucin deposition in the stromal compartment of thyroid parenchyma. Histochemical stainings showed positivity for Alcian blue staining, but not for periodic acid-Shiff staining. Our case is peculiar because this mucin deposition was associated with benign nodular hyperplasia, in contrast with the other 6 reports, which described the same stromal alterations associated with benign or malignant thyroid tumors.
authors.affiliation: 1 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Nesa
authors.affiliation: 1 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Poggi
authors.affiliation: 1 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.|2 University of Milan, Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrero
authors.affiliation: 1 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Del Gobbo
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D009077:Mucins; D013959:Thyroid Diseases / Q000473:pathology*
chemical_list: D009077:Mucins
keywords: mucin deposition; thyroid hyperplasia; thyroid stromal alterations