title: Effect of combined consumption of Lactobacillus brevis KB290 and β-carotene on minor diarrhoea-predominant irritable bowel syndrome-like symptoms in healthy subjects: a randomised, double-blind, placebo-controlled, parallel-group trial.
abstract: People with non-pathological diarrhoea-predominant irritable bowel syndrome (IBS-D)-like symptoms are present at a significant level even in healthy populations, but established prophylaxis is lacking. Previously, we have found that co-administration of Lactobacillus brevis KB290 (KB290) and β-carotene (βC) attenuated murine colitis (potential cause of IBS-D-like symptoms) significantly. Here, we investigated the effect of KB290 and βC on minor IBS-D-like symptoms in healthy volunteers. After a 4-week run-in period, subjects received a KB290 + βC or placebo capsule for 12 weeks, followed by a 4-week washout period. The KB290 + βC group showed a significant improvement in intensity of abdominal pain and stool frequency compared with the placebo group. The KB290 + βC group showed a significantly higher serum concentration of anti-inflammatory cytokine, interleukin-10, compared with the placebo group. In conclusion, we demonstrated that consumption of KB290 + βC improves minor IBS-D-like symptoms and inflammatory status in healthy volunteers. (UMIN000018002).
authors.affiliation: a Nature & Wellness Research Department , Innovation Division, KAGOME CO., LTD , Nasushiobara , Tochigi , Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Fuke
authors.affiliation: a Nature & Wellness Research Department , Innovation Division, KAGOME CO., LTD , Nasushiobara , Tochigi , Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Aizawa
authors.affiliation: a Nature & Wellness Research Department , Innovation Division, KAGOME CO., LTD , Nasushiobara , Tochigi , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suganuma
authors.affiliation: b Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science , Kyoto Prefectural University of Medicine , Kamigyo-ku , Kyoto , Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takagi
authors.affiliation: b Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science , Kyoto Prefectural University of Medicine , Kamigyo-ku , Kyoto , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
mesh_terms: D015746:Abdominal Pain / Q000517:prevention & control; D000328:Adult; D003672:Defecation; D003967:Diarrhea; D004311:Double-Blind Method; D005243:Feces; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome; D052196:Levilactobacillus brevis; D008297:Male; D008875:Middle Aged; D019936:Probiotics; D055815:Young Adult; D019207:beta Carotene / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D019207:beta Carotene
keywords: Lactic acid bacteria; b-carotene; gastro-intestinal; inflammation