title: Group 6 Layered Transition-Metal Dichalcogenides in Lab-on-a-Chip Devices: 1T-Phase WS2for Microfluidics Non-Enzymatic Detection of Hydrogen Peroxide.
abstract: Two-dimensional (2D) layered transition-metal dichalcogenides (TMDs) have been placed in the spotlight for their advantageous properties for catalytic and sensing applications. However, little work is done to explore and exploit them in enhancing the performance of analytical lab-on-a-chip (LOC) devices. In this work, we demonstrate a simple, sensitive, and low-cost fabrication of electrochemical LOC microfluidic devices to be used for enzymatic detection. We integrated four t-BuLi exfoliated, group 6 TMD materials (MoS2, MoSe2, WS2, and WSe2) within the LOC devices by the drop-casting method and compared their performance for H2O2detection. The 1T-phase WS2-based LOC device outperformed the rest of the TMD materials and exhibited a wide range of linear response (20 nM to 20 μM and 100 μM to 2 mM), low detection limit (2.0 nM), and good selectivity for applications in real sample analysis. This work may facilitate the expanded use of electrochemical LOC microfluidics, with its easier integrability, for applications in the field of biodiagnostics and sensing.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Science, Nanyang Technological University , 637371 Singapore.|BioSystems & Micromechanics IRG (BioSyM), Singapore-MIT Alliance for Research and Technology (SMART) Centre, S16-05-08, 3 Science Drive 2, 117543 Singapore.
authors.forename: Rou Jun
authors.initials: RJ
authors.lastname: Toh
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Science, Nanyang Technological University , 637371 Singapore.
authors.forename: Carmen C
authors.initials: CC
authors.lastname: Mayorga-Martinez
authors.affiliation: BioSystems & Micromechanics IRG (BioSyM), Singapore-MIT Alliance for Research and Technology (SMART) Centre, S16-05-08, 3 Science Drive 2, 117543 Singapore.|Department of Electrical Engineering and Computer Science, Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Jongyoon
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Inorganic Chemistry, University of Chemistry and Technology Prague , Technicka 5, 166 28 Prague 6, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Sofer
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Science, Nanyang Technological University , 637371 Singapore.
authors.forename: Martin
authors.identifier: 0000-0001-5846-2951
authors.initials: M
authors.lastname: Pumera