title: Leptin levels in children with obstructive sleep apnea syndrome.
abstract: BACKGROUND
  The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children.
  
  
  METHODS
  Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of ≥ 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group.
  
  
  RESULTS
  47 children (51% male and 49% female; mean age 7.8 ± 2.6 years) were recruited. Twenty seven participants were diagnosed with moderate-to-severe OSAS, and twenty children who had AHI < 5 were included in the mild OSAS/primary snoring. The two groups did not differ regarding age, gender and body mass index z score (p> 0.05). Furthermore there were no differences in log serum leptin levels (p= 0.749). Log serum leptin levels correlated with the BMI z score in the whole study group (p= 0.001; r= 0.499) but they were not associated with apnea-hypopnea index, mean and lowest oxygen saturation during sleep.
  
  
  CONCLUSIONS
  Serum leptin levels are affected by adiposity but not by OSAS severity among children with habitual snoring.
authors.affiliation: Department of Child Health and Diseases, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey. sogutayhan29@hotmail.com.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Söğüt
authors.forename: Şerefden
authors.initials: Ş
authors.lastname: Açıkgöz
authors.forename: Lokman
authors.initials: L
authors.lastname: Uzun
authors.forename: Mehmet Birol
authors.initials: MB
authors.lastname: Uğur
authors.forename: Remzi
authors.initials: R
authors.lastname: Altın
authors.forename: Elif
authors.initials: E
authors.lastname: Dağlı
authors.forename: Athanasios
authors.initials: A
authors.lastname: Kaditis
authors.forename: Refika
authors.initials: R
authors.lastname: Ersu
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D020738:Leptin / Q000097:blood*; D008297:Male; D063766:Pediatric Obesity; D017286:Polysomnography; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications; D012913:Snoring / Q000209:etiology
chemical_list: D015415:Biomarkers; D020738:Leptin