title: Blood to skin recirculation of CD4+memory T cells associates with cutaneous and systemic manifestations of psoriatic disease.
abstract: Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6+CD4+TEMand TEFFcells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3+CD4+TEMcells negatively correlated with the severity of the cutaneous disease. Importantly CLA+CD4+TCMcells expressing CCR6+or CCR4+CXCR3+negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CLA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4+T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis.
authors.affiliation: I.R.C.C.S Istituto Ortopedico Galeazzi, Department of Dermatology and Venereology, University of Milan, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Diani
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Galasso
authors.affiliation: I.R.C.C.S Istituto Ortopedico Galeazzi, Department of Dermatology and Venereology, University of Milan, Milan, Italy; I.R.C.C.S Istituto Ortopedico Galeazzi, Laboratory of Translational Immunology, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cozzi
authors.affiliation: I.R.C.C.S Istituto Ortopedico Galeazzi, Laboratory of Translational Immunology, Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Sgambelluri
authors.affiliation: I.R.C.C.S Istituto Ortopedico Galeazzi, Department of Dermatology and Venereology, University of Milan, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Altomare
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Cigni
authors.affiliation: I.R.C.C.S Istituto Ortopedico Galeazzi, Department of Dermatology and Venereology, University of Milan, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Frigerio
authors.affiliation: I.R.C.C.S. Istituto Ortopedico Galeazzi, Laboratory of Clinical Chemistry and Microbiology, University of Milan, Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Drago
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Volinia
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Granucci
authors.affiliation: I.R.C.C.S Istituto Ortopedico Galeazzi, Department of Dermatology and Venereology, University of Milan, Milan, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Altomare
authors.affiliation: I.R.C.C.S Istituto Ortopedico Galeazzi, Laboratory of Translational Immunology, Milan, Italy. Electronic address: eva.reali@grupposandonato.it.
authors.forename: Eva
authors.initials: E
authors.lastname: Reali
mesh_terms: D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D002097:C-Reactive Protein / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D008297:Male; D008562:Membrane Glycoproteins / Q000276:immunology; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology; D012720:Severity of Illness Index; D012867:Skin / Q000276:immunology*; D055815:Young Adult
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; C063419:CTAGE1 protein, human; D016207:Cytokines; D008562:Membrane Glycoproteins; D019707:Receptors, Chemokine; D002097:C-Reactive Protein