title: [Sarcoidosis : Renal manifestations].
abstract: Renal involvement in sarcoidosis is much more common than generally assumed from old epidemiological studies and is often only detected when actively searched for. Many patients with renal sarcoidosis present with no or only few symptoms. The diagnostic work-up of sarcoidosis should always include a possible renal involvement. In cases of impaired renal function, proteinuria or a pathological urine sediment, a renal biopsy specimen should be obtained to assess the type, severity and prognosis of the kidney disease. Treatment is primarily based on the use of corticosteroids. Steroid-sparing agents, such as disease-modifying antirheumatic drugs and infliximab can be applied; however, the evidence for efficacy of these therapies is mostly based on case series and expert opinions. Discontinuation of immunosuppression therapy bears a high risk of relapse.
authors.affiliation: V. Medizinische Klinik, Nephrologie, Endokrinologie, Rheumatologie, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland. christian.loeffler@umm.de.
authors.forename: C
authors.initials: C
authors.lastname: Löffler
authors.affiliation: Medizinische Klinik A, Hämatoonkologie, Nephrologie, Rheumatologie, Klinikum Ludwigshafen, Bremserstr. 79, 67069, Ludwigshafen, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Bergner
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D019317:Evidence-Based Medicine; D006801:Humans; D009393:Nephritis / Q000175:diagnosis* / Q000628:therapy*; D012507:Sarcoidosis / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents
keywords: Corticosteroids; Glomerulonephritis; Granulomatous interstitial nephritis; Nephrocalcinosis; Renal manifestation