title: [Efficacy and safety of linezolid among patients withmethicillin-resistant Staphylococcus aureusbacteremia].
abstract: Objective:To study the efficacy and safety of linezolid for the treatment of patients with bacteremia caused bymethicillin-resistant Staphylococcus aureus(MRSA).Methods:Totally 52 cases of MRSA bacteremia patients, from January 2010 to April 2014 in the First Affiliated Hospital, School of Medicine, Zhejiang University, were retrospectively analyzed. They were classified into two groups based on linezolid therapeutic regimen: primary treatment with linezolid (19 cases) and alternated to linezolid (33 cases). The following data were collected and compared: clinical characteristics, lasting time of fever, bacterial clearance rate, clinical efficacy, fatality rate, and adverse events.Results:Forty three of the 52 patients (82.7%) suffered complicated MRSA bacteremia. The most common clinical feature was fever[86.5%(45/52)]. Linezolid was initiatively used mostly because of renal insufficiency[68.4%(13/19)]. In the other 33 patient, glycopeptides were initiatively used, then alternated to linezolid because of persistent fever[69.7%(23/33)]; damage of kidney function during treatment period of glycopeptides[12.1%(4/33)]; occurrence of new infectious site related to MRSA[18.2%(6/33)]. The clinical efficacy were 78.9%(15/19) in the group of primary treatment with linezolid and 81.8% (27/33) in the group of alternated to linezolid, persistent time of fever were 4(3, 15) d and 12(5, 24) d, mortality during 28 d period were 15.8% (3/19) and 9.1% (3/33), adverse rate were 15.8% (3/19) and 12.1% (4/33) in these two groups, respectively (allP>0.05).Conclusion:Linezolid is an option with high clinical efficacy and good safety for MRSA bacteremia patients.
authors.affiliation: Department of Respiratory Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China (Chen Shenglan now is working at the Department of Respiratory, Shaoxing Central Hospital, Shaoxing 312030, China).
authors.forename: S L
authors.initials: SL
authors.lastname: Chen
authors.forename: C Y
authors.initials: CY
authors.lastname: Zhu
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.forename: Y H
authors.initials: YH
authors.lastname: Shen
authors.forename: J Y
authors.initials: JY
authors.lastname: Zhou
mesh_terms: D000081:Acetamides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy*; D006801:Humans; D000069349:Linezolid / Q000009:adverse effects* / Q000627:therapeutic use; D008712:Methicillin; D055624:Methicillin-Resistant Staphylococcus aureus; D023303:Oxazolidinones; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid; D008712:Methicillin
keywords: Linezolid; Methicillin resistance; Staphylococal infections; Treatment outcome