title: Apparatus for Histological Validation ofIn VivoandEx VivoMagnetic Resonance Imaging of the Human Prostate.
abstract: This article describes apparatus to aid histological validation of magnetic resonance imaging studies of the human prostate. The apparatus includes a 3D-printed patient-specific mold that facilitates alignedin vivoandex vivoimaging,in situtissue fixation, and tissue sectioning with minimal organ deformation. The mold and a dedicated container include MRI-visible landmarks to enable consistent tissue positioning and minimize image registration complexity. The inclusion of high spatial resolutionex vivoimaging aids in registration ofin vivoMRI and histopathology data.
authors.affiliation: Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney , Sydney, NSW , Australia.
authors.forename: Roger M
authors.initials: RM
authors.lastname: Bourne
authors.affiliation: Centre for Medical Image Computing, University College London , London , UK.
authors.forename: Colleen
authors.initials: C
authors.lastname: Bailey
authors.affiliation: Centre for Medical Imaging, University College London , London , UK.
authors.forename: Edward William
authors.initials: EW
authors.lastname: Johnston
authors.affiliation: Centre for Molecular Intervention, University College London , London , UK.
authors.forename: Hayley
authors.initials: H
authors.lastname: Pye
authors.affiliation: Centre for Molecular Intervention, University College London , London , UK.
authors.forename: Susan
authors.initials: S
authors.lastname: Heavey
authors.affiliation: Centre for Molecular Intervention, University College London , London , UK.
authors.forename: Hayley
authors.initials: H
authors.lastname: Whitaker
authors.affiliation: Centre for Advanced Biomedical Imaging, University College London , London , UK.
authors.forename: Bernard
authors.initials: B
authors.lastname: Siow
authors.affiliation: Department of Research Pathology, University College London , London , UK.
authors.forename: Alex
authors.initials: A
authors.lastname: Freeman
authors.affiliation: Division of Surgery and Interventional Science, University College London, London, UK; Department of Urology, University College London Hospitals, London, UK.
authors.forename: Greg L
authors.initials: GL
authors.lastname: Shaw
authors.affiliation: Division of Surgery and Interventional Science, University College London, London, UK; Department of Urology, University College London Hospitals, London, UK.
authors.forename: Ashwin
authors.initials: A
authors.lastname: Sridhar
authors.affiliation: Centre for Medical Image Computing, University College London , London , UK.
authors.forename: Thomy
authors.initials: T
authors.lastname: Mertzanidou
authors.affiliation: Centre for Medical Image Computing, University College London , London , UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hawkes
authors.affiliation: Centre for Medical Image Computing, University College London , London , UK.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Alexander
authors.affiliation: Centre for Medical Imaging, University College London , London , UK.
authors.forename: Shonit
authors.initials: S
authors.lastname: Punwani
authors.affiliation: Centre for Medical Image Computing, University College London , London , UK.
authors.forename: Eleftheria
authors.initials: E
authors.lastname: Panagiotaki
keywords: MRI validation; co-registration; ex vivo MRI; fixation; histology; in vivo MRI; prostate; prostate cancer