title: Adult stem cells in psychiatric disorders - New discoveries in peripheral blood.
abstract: The new area of research in psychiatric disorders is concerned with abnormal regeneration processes. The role of brain neurogenesis has been studied for decades. New discoveries, concerned with the pluripotency of VSEL cells and the role of factors involved in stem cell trafficking in peripheral blood create hope that it will be possible to develop a better understanding of the processes of neuroregeneration/neurodegeneration. There is an ongoing research investigating concentrations of: sphingosine -1-phosphate, SDF-1, elements of complement cascade, and stem cells in peripheral blood, including their possible connection to psychiatric disorders. Collected data, suggesting an abnormal course of regeneration processes in psychiatric disorders, raises hope of finding new potential markers of psychosis and anxiety disorders.
authors.affiliation: Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 71-460 Szczecin, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kucharska-Mazur
authors.affiliation: Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 71-460 Szczecin, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Jabłoński
authors.affiliation: Department of Genetics, Wroclaw Medical University, Marcinkowskiego 1, 50-368 Wrocław, Poland.
authors.forename: Błażej
authors.initials: B
authors.lastname: Misiak
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, Pasteur 10, 50-367 Wroclaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Frydecka
authors.affiliation: Department of Adult Psychiatry, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Rybakowski
authors.affiliation: Department of Regenerative Medicine, Warsaw Medical University, Poland.
authors.forename: Mariusz Z
authors.initials: MZ
authors.lastname: Ratajczak
authors.affiliation: Department of Psychiatry, Pomeranian University of Medicine, Broniewskiego 26, 71-460 Szczecin, Poland. Electronic address: samoj@pum.edu.pl.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D001008:Anxiety Disorders / Q000097:blood*; D001714:Bipolar Disorder / Q000097:blood*; D053595:Embryonic Stem Cells / Q000502:physiology*; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D012559:Schizophrenia / Q000097:blood*
keywords: Anxiety disorder; Bipolar disorder; Complement cascade; Schizophrenia; Sphingosine-1-phosphate; Stem cell; VSEL