title: RNA sequence analysis of rat acute experimental pancreatitis with and without fatty liver: a gene expression profiling comparative study.
abstract: Fatty liver (FL) is one of the risk factors for acute pancreatitis and is also indicative of a worse prognosis as compared to acute pancreatitis without fatty liver (AP). The aim of the present study was to analyze, at the hepatic level, the differentially expressed genes (DEGs) between acute pancreatitis with fatty liver (APFL) rats and AP rats. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses of these DEGs indicated that PPARα signalling pathway and fatty acid degradation pathway may be involved in the pathological process of APFL, which indicated that fatty liver may aggravate pancreatitis through these pathways. Moreover, the excessive activation of JAK/STAT signaling pathway and toll-like receptor signaling pathway was also found in APFL group as shown in heat map. In conclusion, the inhibition of PPARα signaling pathway and the fatty acid degradation pathway may lead to the further disorder of lipid metabolism, which can aggravate pancreatitis.
authors.affiliation: Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 201907, China.
authors.forename: Hongkai
authors.initials: H
authors.lastname: Yan
authors.affiliation: Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of General Surgery, The General Hospital of the People's Liberation Army, Beijing, 100039, China.
authors.forename: Zhaoyan
authors.initials: Z
authors.lastname: Qiu
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, 710032, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Bai
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, 710032, China.
authors.forename: Shiqi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, 710032, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Yu
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, 710032, China.
authors.forename: Quanxin
authors.initials: Q
authors.lastname: Feng
authors.affiliation: Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, 710032, China. zhaoqc@fmmu.edu.cn.
authors.forename: Qingchuan
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China. xianlihe@126.com.
authors.forename: Xianli
authors.initials: X
authors.lastname: He
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 201907, China. chaoxuliu@yahoo.com.|Department of Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, 710032, China. chaoxuliu@yahoo.com.
authors.forename: Chaoxu
authors.initials: C
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000818:Animals; D001706:Biopsy; D019295:Computational Biology; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000150:complications* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D063990:Gene Ontology; D053858:Metabolic Networks and Pathways; D047493:PPAR alpha / Q000378:metabolism; D010195:Pancreatitis / Q000150:complications* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D015203:Reproducibility of Results; D017423:Sequence Analysis, RNA; D015398:Signal Transduction; D059467:Transcriptome
chemical_list: D005227:Fatty Acids; D047493:PPAR alpha