title: Determination of the Absolute Configuration of Khellactone Esters from Peucedanum japonicum Roots.
abstract: Sixteen new angular dihydropyranocoumarins (1-16) and 24 known compounds were isolated from the roots of Peucedanum japonicum Thunb. The absolute configuration of diacylkhellactone was established by partial hydrolysis, the Mosher method, and X-ray crystallography. In addition, ECD spectroscopy was used to assign the absolute configurations of several of the angular dihydropyranocoumarins. Enantiomers were detected by RP-HPLC using MTPA esters while acyl migration of the substituents was observed in cis-monoacylkhellactones.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
authors.forename: Min Jee
authors.initials: MJ
authors.lastname: Hong
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
authors.forename: Jinwoong
authors.identifier: 0000-0001-9579-738X
authors.initials: J
authors.lastname: Kim
mesh_terms: D019661:Apiaceae; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D004952:Esters / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D004952:Esters; D010936:Plant Extracts; C520900:khellactone