title: EBV-Positive B-Cell Proliferations of Varied Malignant Potential: 2015 SH/EAHP Workshop Report-Part 1.
abstract: OBJECTIVE
  The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review B-cell proliferations of varied malignant potential associated with immunodeficiency.
  
  
  METHODS
  The Workshop Panel reviewed all cases of B-cell hyperplasias, polymorphic B-lymphoproliferative disorders, Epstein-Barr virus (EBV)-positive mucocutaneous ulcer, and large B-cell proliferations associated with chronic inflammation and rendered consensus diagnoses. Disease definitions, boundaries with more aggressive B-cell proliferations, and association with EBV were explored.
  
  
  RESULTS
  B-cell proliferations of varied malignant potential occurred in all immunodeficiency backgrounds. Presentation early in the course of immunodeficiency and in younger age groups and regression with reduction of immunosuppression were characteristic features. EBV positivity was essential for diagnosis in some hyperplasias where other specific defining features were absent.
  
  
  CONCLUSIONS
  This spectrum of B-cell proliferations show similarities across immunodeficiency backgrounds. Localized forms of immunodeficiency disorders arise in immunocompetent patients most likely due to chronic immune stimulation and, despite aggressive histologic features, often show indolent clinical behavior.
authors.affiliation: From the Stanford University School of Medicine, Stanford, CA.
authors.forename: Yasodha
authors.initials: Y
authors.lastname: Natkunam
authors.affiliation: HMDS, St James's University Hospital, Leeds, United Kingdom.
authors.forename: John R
authors.initials: JR
authors.lastname: Goodlad
authors.affiliation: Weill Medical College of Cornell University, New York, NY.
authors.forename: Amy
authors.initials: A
authors.lastname: Chadburn
authors.affiliation: VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: Daphne
authors.initials: D
authors.lastname: de Jong
authors.affiliation: From the Stanford University School of Medicine, Stanford, CA.
authors.forename: Dita
authors.initials: D
authors.lastname: Gratzinger
authors.affiliation: Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: John K C
authors.initials: JK
authors.lastname: Chan
authors.affiliation: University of California Los Angeles Medical Center, Los Angeles.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Said
authors.affiliation: National Institutes of Health, Bethesda, MD.
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Jaffe
mesh_terms: D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology* / Q000821:virology; D002648:Child; D002675:Child, Preschool; D004493:Education; D020031:Epstein-Barr Virus Infections / Q000473:pathology*; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
keywords: Autoimmune; EBV; Early lesion; HIV; Iatrogenic; Nondestructive lesion; Polymorphic lymphoproliferative disorder; Posttransplant lymphoproliferative disorder