title: Characteristics and early clinical outcomes of patients undergoing totally subcutaneous vs. transvenous single chamber implantable cardioverter defibrillator placement.
abstract: In 2012, the first totally Subcutaneous Implantable Cardioverter-Defibrillator (S-ICD) was approved by the Food and Drug Administration (FDA) in the United States. A possible benefit of this device is that it does not involve placing leads 'in' or 'on' the heart, potentially reducing complications.
  
  
  
  Ninety-one S-ICD and 182 single chamber TV-ICD implants were performed between 10/22/2012 and 9/22/2015. During this period of time, 91 patients with S-ICD were matched to TV-ICD patients using single centre NCDR ICD Registry Data based on dialysis status, gender, and age. Intra- and post-operative complications and deaths were examined within the first 180 days following implantation. Patients with S-ICDs had higher creatinine (2.3 ± 2.5 vs. 1.1 ± 0.7, P < 0.001) and were more likely to be on chronic dialysis (20.9% vs. 5.5%, P < 0.001) than TV-ICD patients. Patients in the S-ICD group were more likely to have had prior device infections (14.3% vs. 3.3%, P = 0.021) as well as prior TIA/CVA (14.3% vs. 4.4%, P = 0.049) compared to patients in the TV-ICD group. Seven patients experienced 7 complications or death in TV-ICD group and 5 patients experienced 7 complications or death in SQ-ICD group, P = 0.774.
  
  
  
  In this retrospective matched single centre cohort study, there was no significant difference in implantation complications or death in patients receiving single chamber TV-ICDs compared to S-ICDs within 6 months following implantation. This occurred despite more severe preexisting illness in the S-ICD group. Further investigation is needed to determine outcomes after longer-term follow-up.
authors.affiliation: Cooper Medical School of Rowan University, Camden, NJ, USA.
authors.forename: Ali A
authors.initials: AA
authors.lastname: Mithani
authors.affiliation: Cooper Medical School of Rowan University, Camden, NJ, USA.
authors.forename: Heaton
authors.initials: H
authors.lastname: Kath
authors.affiliation: Cooper Medical School of Rowan University, Camden, NJ, USA.
authors.forename: Krystal
authors.initials: K
authors.lastname: Hunter
authors.affiliation: Cooper Medical School of Rowan University, Camden, NJ, USA.
authors.forename: John
authors.initials: J
authors.lastname: Andriulli
authors.affiliation: Cooper Medical School of Rowan University, Camden, NJ, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Ortman
authors.affiliation: Cooper Medical School of Rowan University, Camden, NJ, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Field
authors.affiliation: Cooper Medical School of Rowan University, Camden, NJ, USA.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Russo
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000009:adverse effects / Q000295:instrumentation* / Q000401:mortality; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Complications ; Implantable cardioverter-defibrillator ; Outcomes; Subcutaneous ICD 