title: Egg Consumption and Incidence of Heart Failure: A Meta-Analysis of Prospective Cohort Studies.
abstract: BACKGROUND
  Heart failure (HF) remains a major health problem affecting 5.7 million adults in USA. Data on the association of egg consumption with incident HF have been inconsistent. We, therefore, conducted this meta-analysis of prospective cohort studies to assess the relation of egg consumption with incident HF in the general population.
  
  
  METHODS
  Using extensive online search, we conducted a meta-analysis of new onset HF following exposure to egg consumption. A random effects model was used and between studies heterogeneity was estimated withI2. Publication bias was assessed graphically using a funnel plot. All analyses were performed with Comprehensive Meta-Analysis (version 2.2.064).
  
  
  RESULTS
  We identified four prospective cohorts for a total of 105,999 subjects and 5,059 cases of new onset HF. When comparing the highest (≥1/day) to the lowest category of egg consumption, pooled relative risk of HF was 1.25 (95% confidence interval = 1.12-1.39;p= 0.00). There was no evidence for heterogeneity (I2= 0%) nor publication bias. On sensitivity analysis, stratification by gender differences, follow-up duration, and region where study was conducted did not alter the main conclusion.
  
  
  CONCLUSIONS
  Our meta-analysis suggests an elevated risk of incident HF with frequent egg consumption.
authors.affiliation: Department of Cardiology, Mercy St. Vincent Medical Center , Toledo, OH , USA.
authors.forename: Owais
authors.initials: O
authors.lastname: Khawaja
authors.affiliation: Department of Cardiology, Mercy St. Vincent Medical Center , Toledo, OH , USA.
authors.forename: Hemindermeet
authors.initials: H
authors.lastname: Singh
authors.affiliation: Department of Cardiology, Mercy St. Vincent Medical Center , Toledo, OH , USA.
authors.forename: Faraz
authors.initials: F
authors.lastname: Luni
authors.affiliation: Department of Cardiology, Mercy St. Vincent Medical Center , Toledo, OH , USA.
authors.forename: Ameer
authors.initials: A
authors.lastname: Kabour
authors.affiliation: Department of Cardiology, Mercy St. Vincent Medical Center , Toledo, OH , USA.
authors.forename: Syed S
authors.initials: SS
authors.lastname: Ali
authors.affiliation: Department of Cardiology, Mercy St. Vincent Medical Center , Toledo, OH , USA.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Taleb
authors.affiliation: Department of Cardiology, Mercy St. Vincent Medical Center , Toledo, OH , USA.
authors.forename: Hafeezuddin
authors.initials: H
authors.lastname: Ahmed
authors.affiliation: Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, MA, USA; Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA, USA.
authors.forename: John Michael
authors.initials: JM
authors.lastname: Gaziano
authors.affiliation: Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA, USA.
authors.forename: Luc
authors.initials: L
authors.lastname: Djoussé
keywords: diet; eggs; epidemiology; heart failure; nutrition