title: [Antibiotic stewardship and Staphylococcus aureus Bacteremia].
abstract: Rates of antibiotic resistance are increasing worldwide and impact on the treatment of patients with bacterial infections. A broad and uncritical application in inpatient and outpatient settings as well as in agriculture has been recognized as the main driving force. Antibiotic stewardship (ABS) programs aim at countering this worrisome development using various direct interventions such as infectious disease counseling. Blood stream infections caused by Staphylococcus (S.) aureus are severe infections associated with high mortality rates. ABS interventions such as de-eskalation of the antibiotic regimen or application of narrow-spectrum beta-lactam antibiotics can significantly reduce mortality rates. In this review, we discuss the importance of ABS programs and infectious disease counseling for the treatment of S. aureus blood stream infection.
authors.affiliation: Zentrum für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Am Klinikum 1, 07740, Jena, Deutschland. sebastian.weis@med.uni-jena.de.|Center for Sepsis Control and Care, Universitätsklinikum Jena, Jena, Deutschland. sebastian.weis@med.uni-jena.de.|Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena, Jena, Deutschland. sebastian.weis@med.uni-jena.de.
authors.forename: S
authors.initials: S
authors.lastname: Weis
authors.affiliation: Zentrum für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Am Klinikum 1, 07740, Jena, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Kimmig
authors.affiliation: Zentrum für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Am Klinikum 1, 07740, Jena, Deutschland.|Center for Sepsis Control and Care, Universitätsklinikum Jena, Jena, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Hagel
authors.affiliation: Zentrum für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena, Am Klinikum 1, 07740, Jena, Deutschland.|Center for Sepsis Control and Care, Universitätsklinikum Jena, Jena, Deutschland.
authors.forename: M W
authors.initials: MW
authors.lastname: Pletz
mesh_terms: D000073602:Antimicrobial Stewardship; D016470:Bacteremia / Q000188:drug therapy* / Q000401:mortality; D003430:Cross-Sectional Studies; D024901:Drug Resistance, Multiple, Bacterial; D005858:Germany; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus; D011159:Population Surveillance; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate
keywords: Blood culture; Drug resistance, bacterial; Infection; MRSA; Mortality