title: RYGB Produces more Sustained Body Weight Loss and Improvement of Glycemic Control Compared with VSG in the Diet-Induced Obese Mouse Model.
abstract: Weight regain and type-2 diabetes relapse has been reported in a significant proportion of vertical sleeve gastrectomy (VSG) patients in some studies, but definitive conclusions regarding the long-term comparative effectiveness of VSG and Roux-en-Y gastric bypass (RYGB) surgery are lacking both in humans and rodent models. This study's objective was to compare the effects of murine models of VSG and RYGB surgery on body weight, body composition, food intake, energy expenditure, and glycemic control.
  
  
  
  VSG, RYGB, and sham surgery was performed in high-fat diet-induced obese mice, and the effects on body weight and glycemic control were observed for a period of 12 weeks.
  
  
  
  After the initial weight loss, VSG mice regained significant amounts of body weight and fat mass that were only marginally lower than in sham-operated mice. In contrast, RYGB produced sustained loss of body weight and fat mass up to 12 weeks and drastically improved fasting insulin and HOMA-IR compared with sham-operated mice. Using weight-matched control groups, we also found that the adaptive hypometabolic response to weight loss was blunted by both VSG and RYGB, and that despite large weight/fat regain, fasting insulin and HOMA-IR were markedly improved, but not reversed, in VSG mice.
  
  
  
  VSG is less effective to lastingly suppress body weight and improve glycemic control compared with RYGB in mice. Given similar observations in many human studies, the run towards replacing RYGB with VSG is premature and should await carefully controlled randomized long-term trials with VSG and RYGB.
authors.affiliation: Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Hao
authors.affiliation: Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
authors.forename: R Leigh
authors.initials: RL
authors.lastname: Townsend
authors.affiliation: Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Mumphrey
authors.affiliation: Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Morrison
authors.affiliation: Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
authors.forename: Heike
authors.initials: H
authors.lastname: Münzberg
authors.affiliation: Neurobiology of Nutrition and Metabolism Department, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA, 70808, USA. berthohr@pbrc.edu.
authors.forename: Hans-Rudolf
authors.initials: HR
authors.lastname: Berthoud
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005743:Gastrectomy / Q000379:methods / Q000706:statistics & numerical data; D015390:Gastric Bypass / Q000379:methods / Q000706:statistics & numerical data; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000601:surgery; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001786:Blood Glucose
keywords: Bariatric surgery; Body composition; Energy expenditure; Fasting insulin; Food intake; Metabolic adaptation; Weight regain