title: Asperphenins A and B, Lipopeptidyl Benzophenones from a Marine-Derived Aspergillus sp. Fungus.
abstract: Asperphenins A (1) and B (2), novel diastereomeric lipopeptidyl benzophenone metabolites, were isolated from a marine-derived Aspergillus sp. fungus. On the basis of the results of combined spectroscopic analyses, the structures of these compounds were determined to be linear assemblies of three motifs: a hydroxy fatty acid, a tripeptide, and a trihydroxybenzophenone. The absolute configurations were assigned using chemical modifications and electronic circular dichroism (ECD) calculations. The novel compounds exhibited significant cytotoxicity on diverse cancer cells.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Liao
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Song Yi
authors.initials: SY
authors.lastname: Bae
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Won
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Minjung
authors.initials: M
authors.lastname: You
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Dong-Chan
authors.identifier: 0000-0001-6405-5535
authors.initials: DC
authors.lastname: Oh
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Sang Kook
authors.identifier: 0000-0002-4306-7024
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-921, Korea.
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Jongheon
authors.identifier: 0000-0002-7536-8462
authors.initials: J
authors.lastname: Shin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D001577:Benzophenones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D055666:Lipopeptides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008968:Molecular Conformation; D064210:Secondary Metabolism
chemical_list: D000970:Antineoplastic Agents; D001577:Benzophenones; D055666:Lipopeptides