title: Dynamics of hormonal disorders following unilateral orchiectomy for a testicular tumor.
abstract: Testicular tumors and their treatment interfere with homeostasis, hormonal status included. The aim of the study was to evaluate hormonal disorders of the pituitary-gonadal axis in men treated for testicular tumors. One hundred twenty-eight men treated for a unilateral testicular tumor at our institution were included. The hormonal status was prospectively evaluated in 62 patients before orchiectomy, 120 patients 1 month after orchiectomy and 110 patients at least 1 year after the treatment. The concentrations of human chorionic gonadotropin (hCG), testosterone (T), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin were measured. The clinically significant testosterone deficiency was defined either as testosterone <2.31 ng/mL or testosterone within the range of 2.31-3.46 ng/mL but simultaneous with T/LH ratio ≤1. Changes in hormone levels were significant: LH and FSH rose in the course of observation, and the concentration of hCG, testosterone, estradiol decreased. PRL concentration was the lowest at 1 month after orchiectomy. In multivariate analysis, the risk of the clinically significant testosterone deficiency was 0.2107 (95% CI 0.1206-0.3419) prior to orchiectomy, 0.3894 (95% CI 0.2983-0.4889) 1 month after surgery and 0.4972 (95% CI 0.3951-0.5995) 1 year after the treatment. The estradiol concentration was elevated in 40% of patients with recently diagnosed testicular cancer and that was correlated with a higher risk of testosterone deficiency after the treatment completion. Hormonal disorders of the pituitary-gonadal axis in men treated for testicular tumors are frequent. The malignant tissue triggers paraneoplastic disorders that additionally disturb the hormonal equilibrium.
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Paweł J
authors.initials: PJ
authors.lastname: Wiechno
authors.affiliation: Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Kowalska
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland. jakub.kucharz@uj.edu.pl.|Department of Experimental and Clinical Surgery, Jagiellonian University Medical College, Michalowskiego 12 st., Cracow, Poland. jakub.kucharz@uj.edu.pl.
authors.forename: Jakub
authors.initials: J
authors.lastname: Kucharz
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Sadowska
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Michalski
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Poniatowska
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Jońska-Gmyrek
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Rzymkowska
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Karol
authors.initials: K
authors.lastname: Nietupski
authors.affiliation: Department of Uro-Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5 st., 02-781, Warsaw, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Demkow
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D042341:Gonadal Hormones / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy / Q000009:adverse effects* / Q000379:methods; D010902:Pituitary Gland / Q000378:metabolism; D010907:Pituitary Hormones / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism; D013736:Testicular Neoplasms / Q000601:surgery*; D013737:Testis / Q000378:metabolism; D013739:Testosterone / Q000172:deficiency / Q000378:metabolism; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin; D042341:Gonadal Hormones; D010907:Pituitary Hormones; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Hormones; Orchiectomy; Testicular tumor; Testosterone