title: Deregulation of the non-coding genome in leukemia.
abstract: Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.
authors.affiliation: a Tampere Center for Child Health Research, Faculty of Medicine and Life Sciences , University of Tampere and Tampere University Hospital , Tampere , Finland.
authors.forename: Susanna
authors.identifier: 0000-0003-2569-8030
authors.initials: S
authors.lastname: Teppo
authors.affiliation: b Institute of Biomedicine, School of Medicine , University of Eastern Finland , Kuopio , Finland.
authors.forename: Merja
authors.identifier: 0000-0001-6190-3439
authors.initials: M
authors.lastname: Heinäniemi
authors.affiliation: a Tampere Center for Child Health Research, Faculty of Medicine and Life Sciences , University of Tampere and Tampere University Hospital , Tampere , Finland.
authors.forename: Olli
authors.identifier: 0000-0001-9195-0797
authors.initials: O
authors.lastname: Lohi
mesh_terms: D015973:Gene Expression Regulation, Leukemic; D016678:Genome; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism
chemical_list: D015514:Oncogene Proteins, Fusion; D022661:RNA, Untranslated
keywords: GRO-seq; eRNA; leukemia; nascent RNA; transcriptional regulation