title: Effect of gellan gum on the thermogelation property and drug release profile of Poloxamer 407 based ophthalmic formulation.
abstract: The effect of gellan gum on the gelation behavior and in-vitro release of a specific drug named pilocarpine hydrochloride from different ophthalmic formulations based on poloxamer 407 is examined. The mixture of 0.3wt% gellan gum and 18wt% poloxamer (PM) solutions show a considerable increase in gel strength in physiological condition. Gel dissolution rate from PM based formulation is significantly decreased due to the addition of gellan gum. FTIR spectra analysis witnesses an interaction in between OH groups of two polymers which accounts for lowering in gelation temperature of PM-gellan gum based formulations. It is also observed from the cryo-SEM study that the pore size of PM gel decreases with an addition of gellan gum and in-vitro release studies indicate that PM-gellan gum based formulation retain drug better than the PM solution alone. Therefore, the developed formulation has the potential to be utilized as an in-situ ophthalmic drug carrier.
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India; Department of Chemistry, Shahid Matangini Hazra Govt. College for Women, Chakshrikrishnapur, Kulberia, Purba Medinipur, West Bengal -721649, India.
authors.forename: Mitali
authors.initials: M
authors.lastname: Dewan
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Gunjan
authors.initials: G
authors.lastname: Sarkar
authors.affiliation: Huda Group of Institutions, Kanuwamari, Nagaon, Assam 782140, India.
authors.forename: Manas
authors.initials: M
authors.lastname: Bhowmik
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Beauty
authors.initials: B
authors.lastname: Das
authors.affiliation: Secretary, Faculty Council For PG & UG Studies In Science, Jadavpur University, 188 Raja S. C. Mallick Road, Kolkata, West Bengal 700032, India.
authors.forename: Atis Kumar
authors.initials: AK
authors.lastname: Chattoapadhyay
authors.affiliation: Department of Chemical and Biological Engineering, Industrial Membrane Research Institute, University of Ottawa, 161 Louis Pasteur St., Ottawa, ON, K1N 6N5, Canada.
authors.forename: Dipak
authors.initials: D
authors.lastname: Rana
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India. Electronic address: dipankar.chattopadhyay@gmail.com.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Chattopadhyay
mesh_terms: D060433:Administration, Ophthalmic; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005782:Gels; D008958:Models, Molecular; D008968:Molecular Conformation; D010862:Pilocarpine / Q000008:administration & dosage / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D013696:Temperature; D014783:Viscosity
chemical_list: D004337:Drug Carriers; D005782:Gels; D011135:Polysaccharides, Bacterial; D010862:Pilocarpine; D020442:Poloxamer; C048288:gellan gum
keywords: Drug release; Gellan gum; Ophthalmic formulations; Poloxamer 407; Thermogelation property