title: Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab.
abstract: Chronic granulomatous disease (CGD) is a genetically induced disease caused by mutations in one of the components of the NADPH-oxidase in phagocytes, characterized by life-threatening bacterial and fungal infections and granuloma formation. Treatment includes prevention of infectious complications and immunomodulation. However, a standard strategy is not yet defined. The authors report an X-linked CGD female carrier who presented during adulthood with diarrhea and colorectal ulcers, with high impairment of quality of life. Induction with infliximab 5 mg/kg (weeks 0, 2, and 6) with infectious prophylaxis was initiated. She continued infliximab 5 mg/kg every 8 weeks with complete symptomatic response at 15 months.
authors.affiliation: Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal; WGO Porto Training Center, Porto, Portugal.
authors.forename: Armando
authors.initials: A
authors.lastname: Peixoto
authors.affiliation: Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal; WGO Porto Training Center, Porto, Portugal.
authors.forename: Rosa
authors.initials: R
authors.lastname: Coelho
authors.affiliation: Department of Pathology, Centro Hospitalar de São João, Porto, Portugal.
authors.forename: Tiago
authors.initials: T
authors.lastname: Maia
authors.affiliation: Department of Infectious Diseases, Centro Hospitalar São João, Porto, Portugal.
authors.forename: António
authors.initials: A
authors.lastname: Sarmento
authors.affiliation: Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal; WGO Porto Training Center, Porto, Portugal; Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal; MedInUP, Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.
authors.forename: Fernando
authors.initials: F
authors.lastname: Magro
authors.affiliation: Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal; WGO Porto Training Center, Porto, Portugal.
authors.forename: Guilherme
authors.initials: G
authors.lastname: Macedo