title: Specific Polysaccharide Antibody Deficiency Revealed by Severe Bacterial Infections in Adulthood: A Report on 11 Cases.
abstract: We report on 11 cases of specific polysaccharide antibody deficiency (SPAD) revealed in adulthood by severe infections with encapsulated bacteria. Given that immunoglobulin replacement therapy can effectively prevent the recurrence of bacterial infections in this context, SPAD should be considered once other antibody deficiencies have been ruled out.
authors.affiliation: CHU Lille, Institut d'Immunologie.|University of Lille, Inflammation Research International Center.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lopez
authors.affiliation: CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques et Auto-immunes Rares.
authors.forename: Anne
authors.initials: A
authors.lastname: Boucher
authors.affiliation: CHU Hôpital Cochin, Laboratoire d'Immunologie biologique, Plateforme d'Immuno-monitoring Vaccinal, Paris.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Bahuaud
authors.affiliation: CHU Lille, Service Oto-Rhino-Laryngologie et Chirurgie cervico-faciale.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Mortuaire
authors.affiliation: Service Universitaire Régional de Maladies Infectieuses et du Voyageur, Centre Hospitalier Gustave Dron, Tourcoing.
authors.forename: Hugues
authors.initials: H
authors.lastname: Melliez
authors.affiliation: University of Lille, Inflammation Research International Center.|CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques et Auto-immunes Rares.
authors.forename: David
authors.initials: D
authors.lastname: Launay
authors.affiliation: University of Lille, Inflammation Research International Center.
authors.forename: Louis
authors.initials: L
authors.lastname: Terriou
authors.affiliation: CHU Lille, Service de Pneumologie et Immuno-Allergologie, Centre de compétence Maladies Pulmonaires Rares.
authors.forename: Lidwine
authors.initials: L
authors.lastname: Wemeau-Stervinou
authors.affiliation: CHU Lille, Service de Pneumologie et Immuno-Allergologie, Centre de compétence Maladies Pulmonaires Rares.
authors.forename: Benoît
authors.initials: B
authors.lastname: Wallaert
authors.affiliation: CHU Lille, Unité des Maladies Infectieuses.
authors.forename: Karine
authors.initials: K
authors.lastname: Faure
authors.affiliation: CHU Lille, Institut de Microbiologie, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Wallet
authors.affiliation: University of Lille, Inflammation Research International Center.|CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques et Auto-immunes Rares.
authors.forename: Eric
authors.initials: E
authors.lastname: Hachulla
authors.affiliation: CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques et Auto-immunes Rares.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Hatron
authors.affiliation: CHU Lille, Institut d'Immunologie.|University of Lille, Inflammation Research International Center.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Dubucquoi
authors.affiliation: CHU Hôpital Cochin, Laboratoire d'Immunologie biologique, Plateforme d'Immuno-monitoring Vaccinal, Paris.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Batteux
authors.affiliation: CHU Lille, Institut d'Immunologie.|University of Lille, Inflammation Research International Center.
authors.forename: Myriam
authors.initials: M
authors.lastname: Labalette
authors.affiliation: CHU Lille, Institut d'Immunologie.|University of Lille, Inflammation Research International Center.|CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre National de Référence Maladies Systémiques et Auto-immunes Rares.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lefèvre
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000276:immunology / Q000382:microbiology / Q000628:therapy; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D011135:Polysaccharides, Bacterial
keywords: Group A Streptococcus; Haemophilus influenzae type b; Streptococcus pneumonia; primary immunodeficiency; specific polysaccharide antibody deficiency