title: Histopathological characterization of the oral lichenoid disease subtypes and the relation with the clinical data.
abstract: BACKGROUND
  The aim of the study was to analyze the histopathological characteristics of samples with a diagnosis of oral lichenoid disease (OLD) and their link with the location and the type of clinical lesion, and the clinicopathological subtypes.
  
  
  METHODS
  Retrospective study on 85 consecutive patients diagnosed with OLD (58 women and 27 men, mean age of 57.7 years). Clinical and histopathological characterization of each case (modified WHO criteria). Collection of the clinical and histopathological data of the lesions. Descriptive and comparative statistical analysis of the results.
  
  
  RESULTS
  The 78.8% of the cases were considered clinically typical while the 21.2% were considered compatible. Histologically, 52.9% were classified as typical and 47.1% as compatible. Biopsies from "plaque-like" lesions presented hyperkeratosis (p>0.001) and epithelial dysplasia (p=0.06) more frequently. Furthermore, acute inflammation was more evident in erosive-ulcerative lesions (p=0.001). Differences regarding the location of the biopsy were statistically non-significant. However, 42.9% of the tongue biopsies showed epithelial dysplasia.
  
  
  CONCLUSIONS
  The histopathological aspect of this disorder is not specific and does not allow us to differentiate between the main subtypes. Therefore, the main reasons to perform a biopsy in this disorder are to define the differential diagnosis and to rule out epithelial dysplasia or a carcinoma. The final histopathological result may be subject to the type of lesion that is biopsied.
authors.affiliation: Unidad de Patología Oral y Maxilofacial, Servicio Clínica Odontológica, Facultad de Medicina y Enfermería, Universidad del País Vasco, EHU Leioa 48940, Vizcaya, Spain, alberdinavarrojavier@gmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Alberdi-Navarro
authors.forename: X
authors.initials: X
authors.lastname: Marichalar-Mendia
authors.forename: M-J
authors.initials: MJ
authors.lastname: Lartitegui-Sebastián
authors.forename: M-L
authors.initials: ML
authors.lastname: Gainza-Cirauqui
authors.forename: M-A
authors.initials: MA
authors.lastname: Echebarria-Goikouria
authors.forename: J-M
authors.initials: JM
authors.lastname: Aguirre-Urizar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000145:classification* / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies