title: Infertility - Prevention and Management.
abstract: Infertility and subfertility, menstrual irregularities, and decreased parity may occur in women with autoimmune diseases due to multiple factors, including underlying inflammatory disease, gonadotoxic medications, and psychosocial issues related to living with chronic disease. Awareness of these factors, as well as validation and support of patients confronting reproductive challenges, is important for providing comprehensive care to these women. An understanding of the expanding options for fertility preservation strategies during gonadotoxic medications is essential. Referral to a reproductive endocrinology clinic is indicated in this patient population.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, University of Michigan, North Campus Research Complex, B014 G236, 2800 Plymouth Road, SPC 2800, Ann Arbor, MI 48109-2800, USA; Department of Obstetrics and Gynecology, University of Michigan, North Campus Research Complex, B014 G236, 2800 Plymouth Road, SPC 2800, Ann Arbor, MI 48109-2800, USA; Department of Environmental Health Sciences, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Somers
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, University of Michigan, North Campus Research Complex, B014 G236, 2800 Plymouth Road, SPC 2800, Ann Arbor, MI 48109-2800, USA; Department of Obstetrics and Gynecology, University of Michigan, North Campus Research Complex, B014 G236, 2800 Plymouth Road, SPC 2800, Ann Arbor, MI 48109-2800, USA. Electronic address: wmarder@med.umich.edu.
authors.forename: Wendy
authors.initials: W
authors.lastname: Marder
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000031:analogs & derivatives; D006801:Humans; D007030:Hypothalamo-Hypophyseal System; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D027724:Reproductive Techniques, Assisted
chemical_list: D007166:Immunosuppressive Agents; D007987:Gonadotropin-Releasing Hormone; D003520:Cyclophosphamide
keywords: Fertility preservation; Infertility; Systemic autoimmune diseases