title: Real-World Experience with Half-Time Versus Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy.
abstract: To evaluate the real-world experience with half-time photodynamic therapy (PDT) versus half-dose PDT for chronic central serous chorioretinopathy (CSC).
  
  
  
  This multicenter retrospective study enrolled patients who received half-time PDT (with irradiation time shortened to 42 s) or half-dose PDT (with the dosage of verteporfin reduced to 3 mg/m2) for chronic CSC and who were followed up for ≧12 months. The success rate, central subfield retinal thickness (CST), and best-corrected visual acuity (BCVA) were documented in each group of patients.
  
  
  
  A total of 53 eyes from 49 patients were enrolled in this study. Seventeen eyes (15 patients) received half-time PDT and 36 eyes (34 patients) received half-dose PDT. The success rates in both groups were similar at 12 months (94.1% vs. 94.4%; P = 0.543). The mean CST at 1, 6, 12 months decreased significantly when compared with the baseline in both groups (all P < 0.001). The BCVA significantly improved at 6 and 12 months in both groups (all P < 0.05). There were no significant differences in changes of BCVA and changes of CST between the 2 groups at any time point.
  
  
  
  Half-time PDT is a feasible treatment for chronic CSC. It has success rates similar to half-dose PDT at 12 months. There were no significant differences in changes of BCVA and changes of CST between the 2 groups at 1, 6, and 12 months after treatment.
authors.affiliation: 1 Department of Ophthalmology, Chang Gung Memorial Hospital , Keelung, Taiwan .
authors.forename: Shu-Yen
authors.initials: SY
authors.lastname: Peng
authors.affiliation: 2 Department of Ophthalmology, Chang Gung Memorial Hospital , Taoyuan, Taiwan .|3 College of Medicine, Chang Gung University , Taoyuan, Taiwan .
authors.forename: Chi-Chun
authors.initials: CC
authors.lastname: Lai
authors.affiliation: 2 Department of Ophthalmology, Chang Gung Memorial Hospital , Taoyuan, Taiwan .|3 College of Medicine, Chang Gung University , Taoyuan, Taiwan .
authors.forename: Nan-Kai
authors.initials: NK
authors.lastname: Wang
authors.affiliation: 2 Department of Ophthalmology, Chang Gung Memorial Hospital , Taoyuan, Taiwan .|3 College of Medicine, Chang Gung University , Taoyuan, Taiwan .
authors.forename: Wei-Chi
authors.initials: WC
authors.lastname: Wu
authors.affiliation: 2 Department of Ophthalmology, Chang Gung Memorial Hospital , Taoyuan, Taiwan .|3 College of Medicine, Chang Gung University , Taoyuan, Taiwan .
authors.forename: Yih-Shiou
authors.initials: YS
authors.lastname: Hwang
authors.affiliation: 2 Department of Ophthalmology, Chang Gung Memorial Hospital , Taoyuan, Taiwan .|3 College of Medicine, Chang Gung University , Taoyuan, Taiwan .
authors.forename: Kuan-Jen
authors.initials: KJ
authors.lastname: Chen
authors.affiliation: 4 Department of Ophthalmology, Mackay Memorial Hospital , Taipei, Taiwan .
authors.forename: Lee-Jen
authors.initials: LJ
authors.lastname: Chen
authors.affiliation: 4 Department of Ophthalmology, Mackay Memorial Hospital , Taipei, Taiwan .|5 Department of Optometry, Chung Shan Medical University , Taichung, Taiwan .
authors.forename: Shawn
authors.initials: S
authors.lastname: Tsai
authors.affiliation: 4 Department of Ophthalmology, Mackay Memorial Hospital , Taipei, Taiwan .
authors.forename: Wei-Chun
authors.initials: WC
authors.lastname: Chan
authors.affiliation: 2 Department of Ophthalmology, Chang Gung Memorial Hospital , Taoyuan, Taiwan .|3 College of Medicine, Chang Gung University , Taoyuan, Taiwan .
authors.forename: Laura
authors.initials: L
authors.lastname: Liu
authors.affiliation: 1 Department of Ophthalmology, Chang Gung Memorial Hospital , Keelung, Taiwan .|3 College of Medicine, Chang Gung University , Taoyuan, Taiwan .
authors.forename: Ling
authors.initials: L
authors.lastname: Yeung
mesh_terms: D056833:Central Serous Chorioretinopathy / Q000188:drug therapy*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D010778:Photochemotherapy; D011166:Porphyrins / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D013997:Time Factors; D000077362:Verteporfin
chemical_list: D011166:Porphyrins; D000077362:Verteporfin
keywords: central serous chorioretinopathy; half-dose; half-fluence; half-time; photodynamic therapy