title: A priori Prediction of Neoadjuvant Chemotherapy Response and Survival in Breast Cancer Patients using Quantitative Ultrasound.
abstract: Quantitative ultrasound (QUS) can probe tissue structure and analyze tumour characteristics. Using a 6-MHz ultrasound system, radiofrequency data were acquired from 56 locally advanced breast cancer patients prior to their neoadjuvant chemotherapy (NAC) and QUS texture features were computed from regions of interest in tumour cores and their margins as potential predictive and prognostic indicators. Breast tumour molecular features were also collected and used for analysis. A multiparametric QUS model was constructed, which demonstrated a response prediction accuracy of 88% and ability to predict patient 5-year survival rates (p = 0.01). QUS features demonstrated superior performance in comparison to molecular markers and the combination of QUS and molecular markers did not improve response prediction. This study demonstrates, for the first time, that non-invasive QUS features in the core and margin of breast tumours can indicate breast cancer response to neoadjuvant chemotherapy (NAC) and predict five-year recurrence-free survival.
authors.affiliation: Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Hadi
authors.initials: H
authors.lastname: Tadayyon
authors.affiliation: Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Lakshmanan
authors.initials: L
authors.lastname: Sannachi
authors.affiliation: Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Mehrdad J
authors.initials: MJ
authors.lastname: Gangeh
authors.affiliation: Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Christina
authors.initials: C
authors.lastname: Kim
authors.affiliation: Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
authors.forename: Sonal
authors.initials: S
authors.lastname: Ghandi
authors.affiliation: Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
authors.forename: Maureen
authors.initials: M
authors.lastname: Trudeau
authors.affiliation: Division of Medical Oncology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Pritchard
authors.affiliation: Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
authors.forename: William T
authors.initials: WT
authors.lastname: Tran
authors.affiliation: Department of Anatomic Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Slodkowska
authors.affiliation: Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.|Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Ali
authors.initials: A
authors.lastname: Sadeghi-Naini
authors.affiliation: Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.|Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Czarnota
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D016896:Treatment Outcome; D014463:Ultrasonography