title: Acute and Subacute Oral Toxicity Evaluation ofEriobotrya japonicaLeaf Triterpene Acids in ICR Mice.
abstract: The interest focusing onEriobotrya japonicaleaf triterpene acid (ELTA) has increased recently because of its beneficial effects on health. However, there has been a lack of experimental data on its toxicity. The present study therefore was conducted to evaluate its toxicity in ICR mice. The results showed that ELTA produced neither mortality nor toxicity of the main organs in ICR male and female mice in both acute (0.30, 0.65, 1.39, and 3.00 g·kg-1body weight) and subacute (150, 300, and 600 mg·kg-1BW) 28-day toxicity studies. Because of lacking apparently adverse effects found in the hematology, clinical biochemistry, and histopathology evaluation, results of the present study together with the beneficial effects make ELTA as a promising dietary supplement and indicated that ELTA administered orally might have a large safety margin for human.
authors.affiliation: College of Chemistry, Fuzhou University, Fuzhou 350116, China; Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350116, China.
authors.forename: Feng
authors.identifier: 0000-0003-3574-1186
authors.initials: F
authors.lastname: Li
authors.affiliation: Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350116, China.
authors.forename: Yijia
authors.identifier: 0000-0001-8430-2126
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350116, China.
authors.forename: Qingxian
authors.identifier: 0000-0002-4951-0496
authors.initials: Q
authors.lastname: Li
authors.affiliation: Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350116, China.
authors.forename: Xianai
authors.initials: X
authors.lastname: Shi
authors.affiliation: Institute of Pharmaceutical Biotechnology and Engineering, Fuzhou University, Fuzhou 350116, China.
authors.forename: Yanghao
authors.identifier: 0000-0001-8334-7218
authors.initials: Y
authors.lastname: Guo