title: Endocan Levels and Coronary Collateral Circulation in Stable Angina Pectoris: A Pilot Study.
abstract: We investigated the relationship between endocan (a marker of systemic inflammation) and the development of coronary collateral circulation (CCC) as evaluated by coronary angiography in patients with chronic stable angina pectoris. A total of 90 patients (32 poor CCC and 58 good CCC) were included in this study. Endocan levels were determined using a commercially available sandwich enzyme-linked immunosorbent assay kit with high sensitivity and specificity for detection of human endocan. In multivariate logistic regression analysis, low endocan levels were independently associated with good CCC ( P < .001). Moreover, low high-sensitivity C-reactive protein levels were also independently associated with good CCC ( P = .020). We found an optimal cutoff point for endocan of 1.7 ng/mL; it predicted the presence of good CCC with a sensitivity of 72.4% and specificity of 65.6% ( P < .001). The results of the present study suggest that measurement of endocan level may help clinicians to predict the development of CCC in patients with stable coronary artery disease.
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Gok
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Kundi
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Emrullah
authors.initials: E
authors.lastname: Kiziltunc
authors.affiliation: 2 Biochemistry Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Canan
authors.initials: C
authors.lastname: Topcuoglu
authors.affiliation: 1 Cardiology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Ornek
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000097:blood*; D003097:Collateral Circulation / Q000502:physiology*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis; D003326:Coronary Circulation / Q000502:physiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010865:Pilot Projects; D011509:Proteoglycans / Q000097:blood*
chemical_list: C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans
keywords: coronary collateral circulation; endocan; inflammation