title: Ibrutinib, a Bruton's tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil activation test reactivity.
authors.affiliation: Division of Allergy-Immunology and Robert H. Lurie Comprehensive Cancer Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Regan
authors.affiliation: Division of Allergy-Immunology and Robert H. Lurie Comprehensive Cancer Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
authors.forename: Yun
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Division of Allergy-Immunology and Robert H. Lurie Comprehensive Cancer Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
authors.forename: Melanie C
authors.initials: MC
authors.lastname: Dispenza
authors.affiliation: Division of Hematology-Oncology and Robert H. Lurie Comprehensive Cancer Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
authors.forename: Shuo
authors.initials: S
authors.lastname: Ma
authors.affiliation: Division of Hematology-Oncology and Robert H. Lurie Comprehensive Cancer Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
authors.forename: Leo I
authors.initials: LI
authors.lastname: Gordon
authors.affiliation: Division of Hematology-Oncology and Robert H. Lurie Comprehensive Cancer Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Petrich
authors.affiliation: Division of Allergy-Immunology and Robert H. Lurie Comprehensive Cancer Center, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address: bruce.bochner@northwestern.edu.
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Bochner
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D000077329:Agammaglobulinaemia Tyrosine Kinase / Q000037:antagonists & inhibitors*; D000368:Aged; D000485:Allergens / Q000276:immunology; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D001491:Basophils / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010880:Piperidines; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011720:Pyrazoles / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D012882:Skin Tests
chemical_list: D000485:Allergens; D018926:Anti-Allergic Agents; D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; C551803:ibrutinib; D000077329:Agammaglobulinaemia Tyrosine Kinase; D000225:Adenine