title: Molecular biomarkers for lung adenocarcinoma.
abstract: The identification of oncogenic driver alterations that underlie sensitivity to small inhibitors has led to growing interest in identifying additional targetable oncogenes in nonsmall cell lung cancer. Although the therapeutic impact of the discovery of these alterations has now been widely demonstrated, the epidemiological data associated with each of these biomarkers remain insufficiently studied. In this review, we discuss the techniques used to discover each of these candidate oncogenes, their prevalence in nonsmall cell lung cancer, and briefly outline the epidemiological features of the major oncogenes and ways in which their identification can determine therapeutic strategies.
authors.affiliation: Inserm, Centre de Recherche en Cancérologie de Toulouse, CRCT UMR-1037, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Calvayrac
authors.affiliation: Inserm, Centre de Recherche en Cancérologie de Toulouse, CRCT UMR-1037, Toulouse, France.|Institut Universitaire du Cancer, Toulouse, France.|Institut Claudius Regaud, IUCT-Oncopole, Laboratoire de Biologie Médicale Oncologique, Toulouse, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Pradines
authors.affiliation: Inserm, Centre de Recherche en Cancérologie de Toulouse, CRCT UMR-1037, Toulouse, France.|Institut Claudius Regaud, IUCT-Oncopole, Laboratoire de Biologie Médicale Oncologique, Toulouse, France.
authors.forename: Elvire
authors.initials: E
authors.lastname: Pons
authors.affiliation: Inserm, Centre de Recherche en Cancérologie de Toulouse, CRCT UMR-1037, Toulouse, France mazieres.j@chu-toulouse.fr.|Institut Universitaire du Cancer, Toulouse, France.|Hôpital Larrey, Centre Hospitalier Universitaire, Université Paul Sabatier, Toulouse, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Mazières
authors.affiliation: Inserm, Centre de Recherche en Cancérologie de Toulouse, CRCT UMR-1037, Toulouse, France.|Institut Universitaire du Cancer, Toulouse, France.|Hôpital Larrey, Centre Hospitalier Universitaire, Université Paul Sabatier, Toulouse, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guibert
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D009154:Mutation; D009857:Oncogenes / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor