title: [Reflections on treatments for infertility and the possible occurrence of ovarian carcinomas.]
abstract: In the last decade the use of assisted reproduction techniques (ART) significantly increased and, due to the improved quality of the procedures and management of patients, it has led to progressively better outcomes. In parallel, the latest literature data show an increased incidence of ovarian cancer, that to date does not have a protocol with high sensitivity and specificity for early diagnosis. Considering the accumulating evidence about the etiology of ovarian cancer, it has been postulated a correlation between the increasing use of necessary and propaedeutic pharmacological treatments for ART and the increased incidence of this tumor. Despite the current data in the literature do not allow to draw definitive conclusions, the aim of this work is to propose a brief comment on the possible correlation between fertility treatments and the occurrence of ovarian cancer, particularly in women with BRCA mutations.
authors.affiliation: Dipartimento di Medicina Clinica e Molecolare, Facoltà di Medicina e Psicologia, Azienda Ospedaliera Sant'Andrea, Sapienza Università di Roma.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Ferranti
authors.affiliation: Dipartimento di Scienze Ginecologico-Ostetriche e Scienze Urologiche, Azienda Universitaria/Ospedaliera Policlinico Umberto I, Sapienza Università di Roma.
authors.forename: Romana
authors.initials: R
authors.lastname: Prosperi Porta
authors.affiliation: Unità di Psicodiagnostica e Psicologia Clinica, Università di Catania.
authors.forename: Valentina Lucia
authors.initials: VL
authors.lastname: La Rosa
authors.affiliation: Unità di Ginecologia ed Ostetricia, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva "G. Barresi", Università di Messina.
authors.forename: Salvatore Giovanni
authors.initials: SG
authors.lastname: Vitale
authors.affiliation: Unità di Ginecologia ed Ostetricia, Dipartimento di Patologia Umana dell'Adulto e dell'Età Evolutiva "G. Barresi", Università di Messina.
authors.forename: Antonio Simone
authors.initials: AS
authors.lastname: Laganà
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D005260:Female; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000628:therapy*; D009154:Mutation; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects / Q000706:statistics & numerical data*; D012680:Sensitivity and Specificity
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human