title: Development of Mixed metal Metal-organic polyhedra networks, colloids, and MOFs and their Pharmacokinetic applications.
abstract: The coordination networking of discrete metal-organic polyhedra (MOPs) involving different ligands as well as metals is a challenging task due to the features of limited solubility and chemical stability of these polyhedra. An unusual approach, ligand-oriented polyhedral networking via click chemistry and further metal coordination is reported here. An alkyne decorated Cu(II)-MOP self-catalyzes the regioselective click reaction (1,3-dipolar cycloaddition) using azide-functionalized ligands under unconventional reaction conditions. Introducing new metal ions, M(II), interlinks the carboxylic groups on the MOP surfaces creating coordination networks. On the other hand, exposure of the respective individual ligand components in the presence of Cu(II) promotes an in-situ click reaction along with metal coordination generating a new 3D-framework. These materials demonstrated a high drug hosting potential exhibiting a controlled progressive release of anticancer (5-flourouracil) and stimulant (caffeine) drugs in physiological saline at 37 °C. These innovative and unconventional MOP networks provide a significant conceptual advance in understanding.
authors.affiliation: Laboratory of organometallics, catalysis and Ordered Materials, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China.|School of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan, 430070, China.
authors.forename: Nazir
authors.initials: N
authors.lastname: Ahmad
authors.affiliation: Laboratory of organometallics, catalysis and Ordered Materials, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China.|School of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan, 430070, China.|Chemistry Department, Faculty of Science, Fayoum University, Fayoum, 63514, Egypt.
authors.forename: Hussein A
authors.initials: HA
authors.lastname: Younus
authors.affiliation: Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
authors.forename: Adeel H
authors.identifier: http://orcid.org/0000-0002-8335-7026
authors.initials: AH
authors.lastname: Chughtai
authors.affiliation: Department of Inorganic and Physical Chemistry, Laboratory of Organometallic Chemistry and Catalysis, Ghent University, Krijgslaan 281 (S-3), 9000, Ghent, Belgium.
authors.forename: Kristof
authors.identifier: http://orcid.org/0000-0002-2455-8856
authors.initials: K
authors.lastname: Van Hecke
authors.affiliation: Department of Chemistry, University of Gujrat, Gujrat, 50700, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Danish
authors.affiliation: School of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan, 430070, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Gaoke
authors.affiliation: Laboratory of organometallics, catalysis and Ordered Materials, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China. Francis.verpoort@ugent.be.|National Research Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, 634050, Russia. Francis.verpoort@ugent.be.|Ghent University Global Campus Songdo, 119 Songdomunhwa-Ro, Yeonsu-Gu, Incheon, 406-840, South Korea. Francis.verpoort@ugent.be.
authors.forename: Francis
authors.identifier: http://orcid.org/0000-0002-5184-5500
authors.initials: F
authors.lastname: Verpoort
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002110:Caffeine / Q000008:administration & dosage; D000697:Central Nervous System Stimulants / Q000008:administration & dosage; D057930:Click Chemistry / Q000379:methods; D003102:Colloids / Q000138:chemical synthesis / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D065546:Drug Liberation; D005472:Fluorouracil / Q000008:administration & dosage; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000697:Central Nervous System Stimulants; D003102:Colloids; D004337:Drug Carriers; D009942:Organometallic Compounds; D002110:Caffeine; D003300:Copper; D005472:Fluorouracil