title: Implantable batteryless device for on-demand and pulsatile insulin administration.
abstract: Many implantable systems have been designed for long-term, pulsatile delivery of insulin, but the lifetime of these devices is limited by the need for battery replacement and consequent replacement surgery. Here we propose a batteryless, fully implantable insulin pump that can be actuated by a magnetic field. The pump is prepared by simple-assembly of magnets and constituent units and comprises a drug reservoir and actuator equipped with a plunger and barrel, each assembled with a magnet. The plunger moves to noninvasively infuse insulin only when a magnetic field is applied on the exterior surface of the body. Here we show that the dose is easily controlled by varying the number of magnet applications. Also, pump implantation in diabetic rats results in profiles of insulin concentration and decreased blood glucose levels similar to those observed in rats treated with conventional subcutaneous insulin injections.
authors.affiliation: Institute of Medical &Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea.
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Young Bin
authors.initials: YB
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
authors.forename: Byung Hwi
authors.initials: BH
authors.lastname: Kim
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
authors.forename: Cheol
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Cho
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Se-Na
authors.initials: SN
authors.lastname: Kim
authors.affiliation: Institute of Medical &Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea.
authors.forename: Chun Gwon
authors.initials: CG
authors.lastname: Park
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.
authors.forename: Yong-Chan
authors.initials: YC
authors.lastname: Cho
authors.affiliation: Institute of Medical &Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea.|Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.|Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
authors.forename: Young Bin
authors.initials: YB
authors.lastname: Choy
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D015918:Infusion Pumps, Implantable; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D060526:Magnetic Fields; D059346:Magnets; D008297:Male; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin