title: Asian and non-Asian disparities in outcomes of non-nasopharyngeal head and neck cancer.
abstract: To evaluate disparities in overall survival (OS) between Asian and non-Asian patients diagnosed with non-nasopharyngeal head and neck cancer (HNC).
  
  
  
  This was a population-based, retrospective study of patients diagnosed with non-nasopharyngeal HNC of squamous cell carcinoma histology between 2001 and 2010 in British Columbia, Canada.
  
  
  
  Using Kaplan-Meier methods and Cox regression models, we examined the relationship between race and OS.
  
  
  
  A total of 3,036 patients were included in the study. Median age was 64 years, 74% were men, and 7% were Asians. Asians had worse Eastern Cooperative Oncology Group (ECOG) status (29% vs. 23%, P = .07) and larger tumors (33% vs. 21%, P = .02), and were more likely to be diagnosed with oral cavity cancers (38% vs. 25%, P < .001) than non-Asians. Asians were also less likely to receive multimodality therapy than non-Asians (90% vs. 95%, P = .02). Asians were more likely to have never smoked (49% vs. 15%, P < .001) and to be married or with a partner (80% vs. 69%, P = .02). Multivariate models showed that Asians had better OS than non-Asians (hazard ratio [HR] = 0.50, 95% confidence interval [CI] = 0.25-0.99, P = .05). Three-year OS did not differ significantly between Asians and non-Asians (41% vs. 42%, P = .18); however, 5-year OS did (22% vs. 19% P = .03). Stratifying by treatment type, outcomes were comparable in both groups except for radiotherapy alone, where Asians showed significantly better OS (HR = 0.71, 95% CI = 0.51-0.99, P = .04). Advanced age, worse ECOG, greater tumor size, and lack of treatment also correlated with inferior OS.
  
  
  
  Despite several worse prognostic features and less aggressive treatment, Asians tended to exhibit better OS than non-Asians.
  
  
  
  2c. Laryngoscope, 127:2528-2533, 2017.
authors.affiliation: Division of Medical Oncology, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Kim
authors.affiliation: Division of Medical Oncology, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Jennifer T
authors.initials: JT
authors.lastname: Chang
authors.affiliation: Division of Medical Oncology, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Ali
authors.initials: A
authors.lastname: Moghaddamjou
authors.affiliation: Department of Oncology, University of Calgary, Tom Baker Cancer Center, Calgary, Alberta, Canada.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Kornelsen
authors.affiliation: Division of Medical Oncology, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Jenny Y
authors.initials: JY
authors.lastname: Ruan
authors.affiliation: Division of Medical Oncology, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Olson
authors.affiliation: Department of Oncology, University of Calgary, Tom Baker Cancer Center, Calgary, Alberta, Canada.
authors.forename: Winson Y
authors.identifier: 0000-0002-3679-4290
authors.initials: WY
authors.lastname: Cheung
mesh_terms: D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000208:ethnology* / Q000401:mortality / Q000628:therapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000208:ethnology* / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Ethnicity; head and neck cancer; non-nasopharyngeal; outcomes; survival