title: Data on cytotoxicity in HeLa and SU-DHL-4 cells exposed to DPB162-AE compound.
abstract: DPB162-AE is a valuable tool to study store-operated Ca2+entry (SOCE), as this compound was developed as a 2-APB analog that inhibits SOCE more potently and more selectively than 2-APB itself. In addition to this, we showed that, in some conditions, DPB162-AE can deplete the endoplasmic reticulum Ca2+stores in intact cells, including the cervical carcinoma HeLa cell line and the diffuse large B-cell lymphoma SU-DHL-4 cell line. Here, we present data regarding the toxicity of DPB162-AE in HeLa and SU-DHL-4 cells. For further interpretation of the data presented in this article, please see the research article 'DPB162-AE, an inhibitor of store-operated Ca2+entry, can deplete the endoplasmic reticulum Ca2+store' (M. Bittremieux, J. V. Gerasimenko, M. Schuermans, T. Luyten, E. Stapleton, K.J. Alzayady, et al., 2017) [1].
authors.affiliation: KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, 3000 Leuven, Belgium.
authors.forename: Mart
authors.initials: M
authors.lastname: Bittremieux
authors.affiliation: The Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Mikoshiba
authors.affiliation: KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, 3000 Leuven, Belgium.
authors.forename: Geert
authors.initials: G
authors.lastname: Bultynck
keywords: Calcium; Cell lines; Cell toxicity; DPB162-AE