title: Brønsted acid-catalyzed, enantioselective synthesis of 1,4-dihydroquinoline-3-carboxylates via in situ generated ortho-quinone methide imines.
abstract: A straightforward, catalytic, enantioselective approach toward the synthesis of a broad range of 1,4-dihydroquinoline-3-carboxylates is described. Under phosphoric acid catalysis in situ-generated ortho-quinone methide imines reacted with β-keto esters to form the nitrogen heterocycles with good yields and enantioselectivities in just one synthetic step under ambient reactions conditions.
authors.affiliation: Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, D-04103 Leipzig, Germany. schneider@chemie.uni-leipzig.de.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Hodík
authors.forename: Christoph
authors.initials: C
authors.lastname: Schneider