title: Therapeutic targeting of isocitrate dehydrogenase mutant AML.
authors.affiliation: a Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors.forename: Prajwal
authors.initials: P
authors.lastname: Boddu
authors.affiliation: a Department of Leukemia , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors.forename: Gautam
authors.initials: G
authors.lastname: Borthakur
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics; D058990:Molecular Targeted Therapy; D009154:Mutation
chemical_list: D000970:Antineoplastic Agents; D007521:Isocitrate Dehydrogenase
keywords: AG120; AG221; AG881; IDH inhibitors; Isocitrate dehydrogenase; acute myeloid leukemia; hydroxyglutarate; ketoglutarate