title: Cortical Gray Matter MR Imaging in Multiple Sclerosis.
abstract: Several neuropathologic and imaging studies have consistently confirmed that multiple sclerosis affects both white (WM) and gray matter (GM) and that GM damage plays a key role in disability progression. However, differently from WM damage, the less inflammatory cell infiltration, the absence of significant blood-brain barrier damage, the low myelin density in upper cortical layers, as well as technical constraints, make the GM damage almost undetectable by means of conventional MR imaging.
authors.affiliation: Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Policlinico GB Rossi, Piazzale LA Scuro 10, Verona 37134, Italy. Electronic address: massimiliano.calabrese@univr.it.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Calabrese
authors.affiliation: Department of Information Engineering, University of Padova, Via G. Gradenigo 6/a, Padova 35135, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Castellaro
mesh_terms: D001812:Blood-Brain Barrier / Q000473:pathology; D018450:Disease Progression; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D066127:White Matter / Q000473:pathology
keywords: Cortical lesions; Gray matter damage; MR imaging; Multiple sclerosis; Normal-appearing gray matter