title: Interactions of Methylenetetrahydrofolate Reductase Gene Polymorphisms, Folate, and Homocysteine on Blood Pressure in a Chinese Hypertensive Population.
abstract: BACKGROUND
  High blood pressure is related to cardiovascular diseases. We aimed to explore the interactions of methylenetetrahydrofolate reductase (MTHTR) gene C677T and A1298C mutations and folate/homocysteine (Hcy) status on blood pressure in a Chinese hypertensive population.
  
  
  METHODS
  The clinical data in the present study derived from a previous trial (NCT00520247). Genotypes in Hcy pathway enzymes were detected by PCR-RFLP methods. Supine blood pressure was measured with a mercury sphygmomanometer. Serum Hcy was measured by high-performance liquid chromatography, and serum folate was measured by chemiluminescent immunoassay.
  
  
  RESULTS
  This study showed that hyperhomocysteinemia independently elevated diastolic blood pressure (DBP) (β (SE): 2.02 (0.85), p = 0.018). Furthermore, individuals with high Hcy and MTHFR1298AC + CC genotypes showed higher DBP than the normal Hcy and 1298AA carriers (β (SE): 1.81 (0.54), p = 0.001). This correlation was verified by the trend test (p = 0.003). However, polymorphisms of MTHFR C677T, MTR A2756G or MTRR A66G do not affect baseline blood pressure level.
  
  
  CONCLUSIONS
  The present study demonstrated that the MTHFR A1298C mutation accompanied by hyperhomocysteinemia jointly elevated DBP. Further studies are necessary to confirm the role of these genotypes and Hcy on blood pressure in a larger population.
authors.forename: Wen-Xing
authors.initials: WX
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Liao
authors.forename: Chao-Yue
authors.initials: CY
authors.lastname: Hu
authors.forename: Fei
authors.initials: F
authors.lastname: Cheng
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Sun
authors.forename: Ling
authors.initials: L
authors.lastname: Tang
authors.forename: Man-Man
authors.initials: MM
authors.lastname: Wang
authors.forename: Kui-Sheng
authors.initials: KS
authors.lastname: Liu
authors.forename: Dahai
authors.initials: D
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
mesh_terms: D001794:Blood Pressure; D005492:Folic Acid; D005838:Genotype; D006710:Homocysteine; D006801:Humans; D006973:Hypertension; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D020641:Polymorphism, Single Nucleotide
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)