title: Effects of Arginine Vasopressin and V1 Receptor Antagonist on Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage: An Experimental Study.
abstract: OBJECTIVE
  To examine morphological, radiological and biochemical effects of arginine vasopressin (AV) and V1 receptor antagonist on cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) in rabbits.
  
  
  METHODS
  Forty male New Zealand white rabbits were randomly divided into four groups comprising 10 rabbits each. The groups were; 1) Control group, 2) SAH group, 3) SAH+AV group, 4) SAH+V1 antagonist group. Diameters of the basilar artery in all groups were measured on angiograms. All animals were sacrificed two days following basilar angiography and tissue samples of basilar artery were obtained under microscope immediate after craniectomy for ultrastructural and biochemical examinations.
  
  
  RESULTS
  The artery diameters were found to be 50% and 50% at the 30th minute in the groups 2 and 3 respectively. In group 3, CVS was 13% more in comparison with the 2nd group. In group 4, vascular constriction was 34.5% at the 30th minute and about 30.9% at the 300th minute. Despite the increase in regional blood flow, AV did not provide morphological change. Histological appearance was related to vascular stenosis due to CVS. Histological outcome was the best in group 4 because of less CVS.
  
  
  CONCLUSIONS
  Arginine vasopressin plays an important role in CVS. We detected morphological and radiological recovery in basilar artery, besides moderate improvement due to AV receptor antagonist in CVS.
authors.affiliation: Cukurova University, School of Medicine, Department of Neurosurgery, Adana, Turkey.
authors.forename: Dervis Mansuri
authors.initials: DM
authors.lastname: Yilmaz
authors.forename: Ersin
authors.initials: E
authors.lastname: Haciyakupoglu
authors.forename: Serkan
authors.initials: S
authors.lastname: Diril
authors.forename: Leman
authors.initials: L
authors.lastname: Sencar
authors.forename: Erol
authors.initials: E
authors.lastname: Akgul
authors.forename: Sait
authors.initials: S
authors.lastname: Polat
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Haciyakupoglu
authors.forename: Ersin
authors.initials: E
authors.lastname: Nazlican
mesh_terms: D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists / Q000494:pharmacology*; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001488:Basilar Artery / Q000187:drug effects*; D004195:Disease Models, Animal; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D017483:Receptors, Vasopressin; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D020301:Vasospasm, Intracranial / Q000209:etiology*
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin