title: Medina® Embolization Device for the Treatment of Intracranial Aneurysms: Safety and Angiographic Effectiveness at 6 Months.
abstract: The Medina Embolization Device (MED) is a new concept device that combines the design of a detachable coil and the one of an intrasaccular flow disruption device.
  
  
  
  To evaluate the feasibility, safety, and 6- to 9-mo effectiveness of this new device for the treatment of intracranial wide-necked aneurysms.
  
  
  
  Twelve patients (10 females, mean age = 56 yr) with 13 wide-necked intracranial aneurysms (3 ruptured; 10 unruptured) were treated by means of the MED from January 2015 to October 2015. In 15% of the cases, MEDs were used in a standalone fashion; in 85% of the cases, additional regular coils were used. Adjunctive compliant balloon was used in 4 of 13 cases (31%). Procedure-related complications were systematically recorded; discharge and 6- to 9-mo follow-up modified Rankin Scale was assessed. Angiographic follow-up was performed with a mean delay of 5.5 ± 1.7 mo. Occlusion rate was evaluated in postprocedure and at midterm follow-up using the Roy-Raymond scale.
  
  
  
  The deployment of the MED was feasible in all cases. No perforation was recorded. One case of thromboembolic complication was observed in a ruptured anterior communicating artery aneurysm, without any clinical consequence at follow-up. Grade A occlusion rate was 61.5% in postprocedure and 83% at 6-mo follow-up. Two cases (17%) of recanalization were documented angiographically.
  
  
  
  The MED is a new generation device combining the design of a detachable coil and an intrasaccular flow disruption device. According to our early experience, this device is safe and provides a satisfactory occlusion rate at angiographic follow-up of 6 mo.
authors.affiliation: Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Nader-Antoine
authors.initials: NA
authors.lastname: Sourour
authors.affiliation: Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Saskia
authors.initials: S
authors.lastname: Vande Perre
authors.affiliation: Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Federico Di
authors.initials: FD
authors.lastname: Maria
authors.affiliation: Department of Interventional Neuroradiology, Rouen University Hospital, Rouen, France.
authors.forename: Chrysanthi
authors.initials: C
authors.lastname: Papagiannaki
authors.affiliation: Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.|Paris VI University, Pierre et Marie Curie, Paris, France.
authors.forename: Joseph
authors.initials: J
authors.lastname: Gabrieli
authors.affiliation: Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Silvia
authors.initials: S
authors.lastname: Pistocchi
authors.affiliation: Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Bartolini
authors.affiliation: Paris VI University, Pierre et Marie Curie, Paris, France.|Department of Anesthesiology, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Degos
authors.affiliation: Paris VI University, Pierre et Marie Curie, Paris, France.|Department of Neurosurgery, Pitié-Salpêtrière Hospital, Paris, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Carpentier
authors.affiliation: Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.|Paris VI University, Pierre et Marie Curie, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Chiras
authors.affiliation: Department of Interventional Neuroradiology, Pitié-Salpêtrière Hospital, Paris, France.|Paris VI University, Pierre et Marie Curie, Paris, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Clarençon
mesh_terms: D000328:Adult; D000368:Aged; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Intracranial aneurysm; Intrasaccular flow disruption; Medina Embolization Device; Petals