title: Marine Algicolous Endophytic Fungi - A Promising Drug Resource of the Era.
abstract: Endophytic fungi have currently been acknowledged as the most promising source of bioactive compounds for drug discovery, and considerable progress has been made in exploring their diversity, species richness, and bioprospecting. Fungal endophytes from unique environmental settings offer a pool of potentially useful medicinal entities. Owing to the constant stresses imposed on macroalgae by marine environments, it is believed that algae and their associated endophytic symbionts represent a good source of structurally diverse bioactive secondary metabolites. Despite the proven significance of active metabolites of algal endophytes, little have been exploited. This review highlights the latest discoveries in algicolous endophytic research, with particular focus on the bioactive metabolites from algal endophytes. Compounds are classified according to their reported biological activities, like anticancer, antibacterial, antifungal, and antioxidant properties. Present experimental evidence suggests that a majority of the bioactive metabolites were reported from Phaeophyceae followed by Rhodophyceae and Chlorophyceae. An intensive search for newer and more effective bioactive metabolites has generated a treasure trove of publications, and this review partially covers the literature published up to 2016.
authors.affiliation: Department of Marine Biology, Microbiology, and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Kochi-682016, Kerala, India.
authors.forename: Manomi
authors.initials: M
authors.lastname: Sarasan
authors.affiliation: Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Jayesh
authors.initials: J
authors.lastname: Puthumana
authors.affiliation: Department of Marine Biology, Microbiology, and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Kochi-682016, Kerala, India.
authors.forename: Neema
authors.initials: N
authors.lastname: Job
authors.affiliation: Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Jeonghoon
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.
authors.forename: Jae-Seong
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Marine Biology, Microbiology, and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Kochi-682016, Kerala, India.
authors.forename: Rosamma
authors.initials: R
authors.lastname: Philip
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000627:therapeutic use; D055808:Drug Discovery; D060026:Endophytes / Q000737:chemistry / Q000378:metabolism*; D005658:Fungi / Q000737:chemistry / Q000378:metabolism*; D012624:Seaweed / Q000382:microbiology*; D064210:Secondary Metabolism; D013559:Symbiosis
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001688:Biological Products
keywords: Macroalgae; anticancer; antimicrobial; bioactive compound; endophytic fungi; secondary metabolite