title: Asymptomatic hyperuricemia is independently associated with coronary artery calcification in the absence of overt coronary artery disease: A single-center cross-sectional study.
abstract: Recently, the pathogenic role of uric acid (UA) in both systemic metabolic and atherosclerotic diseases has been investigated. We sought to determine the independent correlation between serum UA levels and coronary artery calcification, as a marker of subclinical atherosclerosis. A total of 4188 individuals without prior coronary artery disease or urate-deposition disease were included. All of the participants underwent multidetector computed tomography (MDCT) for the evaluation of coronary artery calcification (CAC) during their health check-ups. The subjects were divided into thre groups according to CAC scores (group 1: 0; group 2: 1-299; group 3: ≥300). After controlling for other confounders, serum UA levels were found to be positively associated with increasing CAC scores (P = 0.001). Adjusted mean serum UA levels in each CAC group were estimated to be 5.2 ± 0.1 mg/dL, 5.3 ± 0.1 mg/dL, and 5.6 ± 0.2 mg/dL from groups 1, 2, and 3, respectively. Subsequent subgroup analyses revealed that this positive association was only significant in participants who were male, relatively older, less overweight, and did not have diabetes mellitus (DM), hypertension, smoking history, or renal dysfunction. In conclusion, serum uric acid levels were independently associated with CAC score severity and this finding is particularly relevant to the subjects who were male, relatively older, less overweight (body mass index < 25 kg/m), and without a history of DM, hypertension, smoking, or renal dysfunction.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine Gangnam Severance Hospital, Seoul Department of Internal Medicine, CHA University School of Medicine CHA Bundang Medical Center, Seongnam-si Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Hyunwook
authors.initials: H
authors.lastname: Kim
authors.forename: Seok-Hyung
authors.initials: SH
authors.lastname: Kim
authors.forename: Ah Ran
authors.initials: AR
authors.lastname: Choi
authors.forename: Seungkyu
authors.initials: S
authors.lastname: Kim
authors.forename: Hoon Young
authors.initials: HY
authors.lastname: Choi
authors.forename: Hyung Jong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Hyeong-Cheon
authors.initials: HC
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D058070:Asymptomatic Diseases; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000150:complications; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D012189:Retrospective Studies; D014527:Uric Acid / Q000097:blood*; D061205:Vascular Calcification / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging
chemical_list: D014527:Uric Acid