title: [Analysis of genetic polymorphisms and mutations of 20 frequently used STR loci among ethnic Hans from Henan].
abstract: OBJECTIVE
  To study the genetic polymorphisms and mutations of 20 frequently used autosomal microsatellites among ethnic Hans from Henan.
  
  
  METHODS
  Peripheral blood samples of 2604 individuals were collected. DNA was amplified and genotyped using a PowerPlex(TM) 21 system. The frequencies, forensic parameters and mutation rates of the 20 short tandem repeat (STR) loci were analyzed.
  
  
  RESULTS
  A total of 323 alleles were found in this population and the allelic frequencies have ranged from 0.0003 to 0.5144. Except for D3S1358, TH01 and TPOX, mutations have been found in all of the remaining 17 STR loci, which totaled 47, with mutation rates ranging from 0 to 3.46 × 10-3.
  
  
  CONCLUSIONS
  The 20 STR loci selected by the PowerPlex(TM) 21 system are highly polymorphic among ethnic Hans from Henan, and may be of great value in forensic and human population studies. As no similar study has been carried out previously, above results may be of great value for individual discrimination and paternal testing.
authors.affiliation: Institute of Medical Genetics of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China. wanghongdan5495@163.com.
authors.forename: Hongdan
authors.initials: H
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Kang
authors.forename: Yue
authors.initials: Y
authors.lastname: Gao
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Huo
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Qiannan
authors.initials: Q
authors.lastname: Guo
authors.forename: Bofeng
authors.initials: B
authors.lastname: Zhu
authors.forename: Shixiu
authors.initials: S
authors.lastname: Liao
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009154:Mutation; D010375:Pedigree; D011110:Polymorphism, Genetic; D055815:Young Adult