title: Plasma cell myeloma with lymphoplasmacytic morphology and cyclin D1 expression, an uncommon variant.
abstract: The genetic complexity of multiple myeloma is due in part to the accumulation of mutations, with primary and secondary events. One such secondary event is the development of a gene mutation that may result in overexpression of cyclin D1. The pathway involving cyclin D1 is intricately involved in cell cycle regulation from the G1 to S phase, and alterations may contribute to tumorigenesis. We present a case of cyclin D1-positive multiple myeloma with lymphoplasmacytic morphology and discuss potential diagnostic pitfalls and effects on prognosis.
authors.affiliation: Department of Pathology (Hale) and the Division of Hematopathology (Krause), the Charles A. Sammons Cancer Center, Dallas, Texas, and Baylor University Medical Center at Dallas.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Hale
authors.affiliation: Department of Pathology (Hale) and the Division of Hematopathology (Krause), the Charles A. Sammons Cancer Center, Dallas, Texas, and Baylor University Medical Center at Dallas.
authors.forename: John R
authors.initials: JR
authors.lastname: Krause