title: Amlodipine: The double edged sword.
abstract: OBJECTIVE
  Amlodipine, a calcium channel blocker became one of the most popular antihypertensive medications used in the paediatric population. This is mainly due to its long half-life making it easy to use as a single daily dose. Amlodipine is associated with common side effects like flushing, headache and dizziness. The incidence of amlodipine-related oedema was noted to be lower in the paediatric population compared to adults. We emphasise the importance of monitoring the development of oedema in patients treated with amlodipine.
  
  
  METHODS
  Hereby, we report four paediatric cases with amlodipine-related generalised oedema.
  
  
  CONCLUSIONS
  Resolution of the oedema with stoppage of amlodipine confirms its culprit as a cause of the oedema. To our knowledge, this is the largest case series of amlodipine-related generalised oedema in the paediatric population.
authors.affiliation: Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Fatma
authors.initials: F
authors.lastname: Rabah
authors.affiliation: Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Naggari
authors.affiliation: Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman.
authors.forename: Dana
authors.initials: D
authors.lastname: Al-Nabhani
mesh_terms: D000367:Age Factors; D017311:Amlodipine / Q000009:adverse effects* / Q000627:therapeutic use; D001795:Blood Pressure Determination; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004487:Edema / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy*; D015994:Incidence; D007223:Infant; D008297:Male; D008991:Monitoring, Physiologic; D061214:Patient Safety; D010372:Pediatrics; D018570:Risk Assessment; D012494:Sampling Studies
chemical_list: D002121:Calcium Channel Blockers; D017311:Amlodipine
keywords: amlodipine; oedema; paediatric