title: Intraperitoneal Injection Is Not a Suitable Administration Route for Single-Walled Carbon Nanotubes in Biomedical Applications.
abstract: Given the extensive application of carbon nanotubes (CNTs) in biomedical fields, there is increasing concern regarding unintentional health impacts. Research into safe usage is therefore increasingly necessary. This study investigated the responses of the mouse brain to single-walled CNTs (SWCNTs) delivered via intraperitoneal (IP) injection and compared these results with the previous study where SWCNTs were delivered via intravenous (IV) injection so as to explore which administration route is potentially better for SWCNTs application. This study suggests SWCNTs delivered via IP injection can have negative effects on the mouse brain through oxidative stress and inflammation at high concentration exposure, but these responses were not consistent and showed no dose-dependent effect. In a previous study, the results showed that IV-delivered SWCNTs induced a more consistent and dose-dependent effect. The comparison of the 2 studies suggested that using SWCNTs at a safe dosage delivered via IV injection may be a better administration route for SWCNTs in biomedical applications.
authors.affiliation: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China; Department of Food science and Engineering, Moutai College, Renhuai, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Food science and Engineering, Moutai College, Renhuai, China.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China.
authors.forename: Jinquan
authors.initials: J
authors.lastname: Li
authors.affiliation: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: College of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: College of Basic Medical Sciences, Hubei University of Science and Technology, Xianning, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ma
authors.affiliation: Laboratory of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Central China Normal University, Wuhan, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
keywords: administration route; intraperitoneal injection; intravenous injection; single-walled carbon nanotubes (SWCNTs)