title: KIF13B-NRG1 Gene Fusion and KRAS Amplification in a Case of Natural Progression of Lung Cancer.
abstract: An 85-year-old woman with a history of several primary lung cancers presented with liver metastases. The primary lung cancers were all managed surgically and the patient did not receive adjuvant or neoadjuvant therapy prior to presenting with metastases. Comparison of molecular testing results from the most recent primary and the liver metastases demonstrated ( a) a clonal relationship between the 2 cancers and ( 2) the presence of a KIF13B-NRG1 fusion and KRAS amplification unique to the metastases. When integrated, the molecular surgical pathology findings in this case illustrate the extent of "oncogenic drive" in preterminal lung cancer.
authors.affiliation: 1 Massachusetts General Hospital, Boston, MA, USA.|2 Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Xia
authors.affiliation: 1 Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Long Phi
authors.initials: LP
authors.lastname: Le
authors.affiliation: 1 Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Anthony John
authors.initials: AJ
authors.lastname: Iafrate
authors.affiliation: 1 Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Jochen
authors.initials: J
authors.lastname: Lennerz
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005784:Gene Amplification; D006801:Humans; D016547:Kinesins / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics* / Q000556:secondary*; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000235:genetics; D020890:Neuregulin-1 / Q000235:genetics; D050596:Oncogene Fusion; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics
chemical_list: C117307:KRAS protein, human; C094131:NRG1 protein, human; D020890:Neuregulin-1; C513406:KIF13B protein, human; D016547:Kinesins; D016283:Proto-Oncogene Proteins p21(ras)
keywords: KRAS amplification; NRG1 fusion; lung cancer; molecular pathology