title: Multifunctional Nanosystem for Synergistic Tumor Therapy Delivered by Two-Dimensional MoS2.
abstract: A multifunctional nanosystem based on two-dimensional molybdenum disulfide (MoS2) was developed for synergistic tumor therapy. MoS2was stabilized with lipoic acid (LA)-modified poly(ethylene glycol) and modified with a pH-responsive charge-convertible peptide (LA-K11(DMA)). Then, a positively charged photosensitizer, toluidine blue O (TBO), was loaded on MoS2via physical absorption. The negatively charged LA-K11(DMA) peptide was converted into a positively charged one under acidic conditions. Charge conversion of the peptide could reduce the binding force between positively charged TBO and MoS2, leading to TBO release. Furthermore, the positively charged nanosystem was easily endocytosed by cells. Photo-induced hyperthermia of MoS2in the tumor areas could promote TBO release and exhibited photothermal therapy. In vitro and in vivo results demonstrated that fluorescence and photo-induced reactive oxygen species (ROS) generation of TBO were severely decreased by MoS2under normal conditions. While in the acidic condition, the pH-responsive nanosystem exhibited a highly specific and efficient antitumor effect with TBO release and photo-induced ROS generation, suggesting to be a promising accessory for synergistic tumor therapy.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry and ‡The Institute for Advanced Studies, Wuhan University , Wuhan 430072, China.
authors.forename: Meng-Yun
authors.initials: MY
authors.lastname: Peng
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry and ‡The Institute for Advanced Studies, Wuhan University , Wuhan 430072, China.
authors.forename: Di-Wei
authors.initials: DW
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry and ‡The Institute for Advanced Studies, Wuhan University , Wuhan 430072, China.
authors.forename: Shi-Bo
authors.initials: SB
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry and ‡The Institute for Advanced Studies, Wuhan University , Wuhan 430072, China.
authors.forename: Si-Xue
authors.identifier: http://orcid.org/0000-0001-9611-4421
authors.initials: SX
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry and ‡The Institute for Advanced Studies, Wuhan University , Wuhan 430072, China.
authors.forename: Xian-Zheng
authors.identifier: http://orcid.org/0000-0001-6242-6005
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D004220:Disulfides / Q000737:chemistry*; D006801:Humans; D008982:Molybdenum / Q000737:chemistry*; D049329:Nanostructures; D009369:Neoplasms; D010778:Photochemotherapy; D017319:Photosensitizing Agents; D010789:Phototherapy; D014048:Tolonium Chloride
chemical_list: D004220:Disulfides; D017319:Photosensitizing Agents; D014048:Tolonium Chloride; D008982:Molybdenum; C082964:molybdenum disulfide
keywords: MoS2 nanoflake; TBO release; charge conversion; photodynamic therapy; photothermal therapy