title: Effects of hyaluronic acid on bleeding following third molar extraction.
abstract: OBJECTIVE
  To explore the effects of hyaluronic acid (HA) on bleeding and associated outcomes after third molar extraction.
  
  
  METHODS
  Forty patients who had undergone molar extraction were randomly divided into two groups; 0.8% (w/v) HA was applied to the HA group (n=20) whereas a control group (n=20) was not treated. Salivary and gingival tissue factor (TF) levels, bleeding time, maximum interincisal opening (MIO), pain scored on a visual analog scale (VAS), and the swelling extent were compared between the two groups.
  
  
  RESULTS
  HA did not significantly affect gingival TF levels. Salivary TF levels increased significantly 1 week after HA application but not in the control group. Neither the VAS pain level nor MIO differed significantly between the two groups. The swelling extent on day 3 and the bleeding time were greater in the HA group than in the control group.
  
  
  CONCLUSIONS
  Local injection of HA at 0.8% prolonged the bleeding time, and increased hemorrhage and swelling in the early postoperative period after third molar extractions.
authors.affiliation: Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, İstanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Gocmen
authors.affiliation: Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, İstanbul, Turkey.
authors.forename: Sertac
authors.initials: S
authors.lastname: Aktop
authors.affiliation: Marmara University, Faculty of Dentistry, Department of Biochemistry, Istanbul, Turkey.
authors.forename: Burcin
authors.initials: B
authors.lastname: Tüzüner
authors.affiliation: Marmara University, Faculty of Pharmacy, Department of Biochemistry, Istanbul, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Goker
authors.affiliation: Marmara University, Faculty of Dentistry, Department of Biochemistry, Istanbul, Turkey.
authors.forename: Aysen
authors.initials: A
authors.lastname: Yarat
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001760:Bleeding Time; D005881:Gingiva / Q000737:chemistry; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D008964:Molar, Third / Q000601:surgery*; D010147:Pain Measurement; D019106:Postoperative Hemorrhage / Q000139:chemically induced*; D011446:Prospective Studies; D012016:Reference Values; D012463:Saliva / Q000737:chemistry; D018709:Statistics, Nonparametric; D013925:Thromboplastin / Q000032:analysis; D013997:Time Factors; D014081:Tooth Extraction / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D006820:Hyaluronic Acid; D013925:Thromboplastin