title: Bone marrow myeloid cells in regulation of multiple myeloma progression.
abstract: Survival, growth, and response to chemotherapy of cancer cells depends strongly on the interaction of cancer cells with the tumor microenvironment. In multiple myeloma, a cancer of plasma cells that localizes preferentially in the bone marrow, the microenvironment is highly enriched with myeloid cells. The majority of myeloid cells are represented by mature and immature neutrophils. The contribution of the different myeloid cell populations to tumor progression and chemoresistance in multiple myeloma is discussed.
authors.affiliation: Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Room 376, Philadelphia, PA, 19104, USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Herlihy
authors.affiliation: Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Room 376, Philadelphia, PA, 19104, USA.
authors.forename: Cindy
authors.initials: C
authors.lastname: Lin
authors.affiliation: Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Room 376, Philadelphia, PA, 19104, USA. ynefedova@wistar.org.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Nefedova
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D063646:Carcinogenesis; D002454:Cell Differentiation; D019008:Drug Resistance, Neoplasm; D006801:Humans; D056747:Immunomodulation; D009101:Multiple Myeloma / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D022423:Myeloid Cells / Q000276:immunology* / Q000473:pathology; D009504:Neutrophils / Q000276:immunology*; D019139:Tumor Escape; D059016:Tumor Microenvironment
keywords: Cancer; Chemoresistance; Multiple myeloma; Myeloid-derived suppressor cells; Neutrophils; Regulatory myeloid suppressor cells