title: Bone-implant degradation and mechanical response of bone surrounding Mg-alloy implants.
abstract: In the present paper, first results of the influence of the degradation of biodegradable materials on the hardness of the bone are presented in detail. For this purpose, different materials (Mg, Ti and biopolymers) were implanted into the femora of growing rats and bone cross sections were examined for the micro-hardness (MH). The aim of the present paper was to examine the mechanical response of the bone areas surrounding the implant at defined sites and at specified periods after implantation. A special focus was set on Mg alloys. In earlier in-vitro and in-vivo studies, an accumulation of Magnesium in the vicinity of the implant was detected by using different techniques. Therefore, micro-hardness measurements were performed, and the mechanical strength of bone was correlated with the exchange of Magnesium and Calcium in Hydroxyapatite. After the operation and implantation, the micro-hardness values became temporarily lower, but after complete degradation of the implants, the values were identical with those of specimens containing no implants.
authors.affiliation: University of Natural Resources and Life Sciences, Institute of Physics and Materials Science, Peter-Jordan-Straße 82, 1190 Vienna, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Meischel
authors.affiliation: University of Natural Resources and Life Sciences, Institute of Physics and Materials Science, Peter-Jordan-Straße 82, 1190 Vienna, Austria.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hörmann
authors.affiliation: University of Natural Resources and Life Sciences Vienna, Department of Chemistry, Division of Analytical Chemistry - VIRIS Laboratory, Tulln, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Draxler
authors.affiliation: Vienna Technical University, Faculty of Physics, Institute of Solid State Physics, Karlsplatz 13, 1040 Vienna, Austria.
authors.forename: Elmar K
authors.initials: EK
authors.lastname: Tschegg
authors.affiliation: Medical University of Graz, Department of Orthopedic Surgery, Auenbruggerplatz 5, 8036 Graz, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Eichler
authors.affiliation: University of Natural Resources and Life Sciences Vienna, Department of Chemistry, Division of Analytical Chemistry - VIRIS Laboratory, Tulln, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Prohaska
authors.affiliation: University of Natural Resources and Life Sciences, Institute of Physics and Materials Science, Peter-Jordan-Straße 82, 1190 Vienna, Austria. Electronic address: stefanie.tschegg@boku.ac.at.
authors.forename: Stefanie E
authors.initials: SE
authors.lastname: Stanzl-Tschegg
mesh_terms: D000497:Alloys; D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D017886:Durapatite / Q000032:analysis*; D008274:Magnesium / Q000032:analysis*; D016348:Osseointegration; D019736:Prostheses and Implants; D051381:Rats
chemical_list: D000497:Alloys; D017886:Durapatite; D008274:Magnesium
keywords: Bone implants; In-vivo degradation; LA-ICP-MS; Magnesium alloys; Micro-hardness; Titanium alloy