title: Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect.
abstract: The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin effect in mice.
authors.affiliation: Laboratory of Molecular Endocrinology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: jhabener@partners.org.
authors.forename: Joel F
authors.initials: JF
authors.lastname: Habener
authors.affiliation: Laboratory of Molecular Endocrinology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Violeta
authors.initials: V
authors.lastname: Stanojevic
mesh_terms: D000818:Animals; D005934:Glucagon; D052216:Glucagon-Like Peptide 1; D054795:Incretins; D007328:Insulin; D051379:Mice; D010179:Pancreas; D010446:Peptide Fragments
chemical_list: D054795:Incretins; D007328:Insulin; D010446:Peptide Fragments; D052216:Glucagon-Like Peptide 1; D005934:Glucagon