title: Spread spectrum time-resolved diffuse optical measurement system for enhanced sensitivity in detecting human brain activity.
abstract: Diffuse optical spectroscopy (DOS) and imaging methods have been widely applied to noninvasive detection of brain activity. We have designed and implemented a low cost, portable, real-time one-channel time-resolved DOS system for neuroscience studies. Phantom experiments were carried out to test the performance of the system. We further conducted preliminary human experiments and demonstrated that enhanced sensitivity in detecting neural activity in the cortex could be achieved by the use of late arriving photons.
authors.affiliation: National University of Singapore, Department of Biomedical Engineering, Singapore, Singapore.
authors.forename: Kalpesh
authors.initials: K
authors.lastname: Mehta
authors.affiliation: National University of Singapore, Department of Biomedical Engineering, Singapore, Singapore.
authors.forename: Ali
authors.initials: A
authors.lastname: Hasnain
authors.affiliation: National University of Singapore, Department of Biomedical Engineering, Singapore, Singapore.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Tsinghua University, School of Medicine, Department of Biomedical Engineering, Beijing, China.
authors.forename: Jianwen
authors.initials: J
authors.lastname: Luo
authors.affiliation: National University of Singapore, Department of Psychology, Singapore, Singapore.
authors.forename: Trevor B
authors.initials: TB
authors.lastname: Penney
authors.affiliation: National University of Singapore, Department of Biomedical Engineering, Singapore, Singapore.
authors.forename: Nanguang
authors.initials: N
authors.lastname: Chen
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D003952:Diagnostic Imaging / Q000379:methods; D004867:Equipment Design; D006801:Humans; D008297:Male; D055096:Optical Devices; D019047:Phantoms, Imaging; D017785:Photons; D011340:Problem Solving; D015203:Reproducibility of Results; D013057:Spectrum Analysis / Q000379:methods; D041622:Tomography, Optical / Q000191:economics / Q000379:methods*