title: Testing for thrombophilia in mesenteric venous thrombosis - Retrospective original study and systematic review.
abstract: The aim was to perform a local study of risk factors and thrombophilia in mesenteric venous thrombosis (MVT), and to review the literature concerning thrombophilia testing in MVT. Patients hospitalized for surgical or medical treatment of MVT at our center 2000-2015. A systematic review of observational studies was performed. In the local study, the most frequently identified risk factor was Factor V Leiden mutation. The systematic review included 14 original studies. The highest pooled percentage of any inherited thrombophilic factor were: Factor V Leiden mutation 9% (CI 2.9-16.1), prothrombin gene mutation 7% (CI 2.7-11.8). The highest pooled percentage of acquired thrombophilic factors were JAK2 V617F mutation 14% (CI -1.9-28.1). The wide range of frequency of inherited and acquired thrombophilic factors in different populations indicates the necessity to relate these factors to background population based data in order to estimate their overrepresentation in MVT. There is a need to develop guidelines for when and how thrombophilia testing should be performed in MVT.
authors.affiliation: Lund University, Department of Vascular Diseases, Skåne University Hospital, S-205 02 Malmö, Sweden. Electronic address: moncef.zarrouk@med.lu.se.
authors.forename: M
authors.initials: M
authors.lastname: Zarrouk
authors.affiliation: Lund University, Department of Vascular Diseases, Skåne University Hospital, S-205 02 Malmö, Sweden. Electronic address: lak13ssa@student.lu.se.
authors.forename: S
authors.initials: S
authors.lastname: Salim
authors.affiliation: Lund University, Department of Vascular Diseases, Skåne University Hospital, S-205 02 Malmö, Sweden. Electronic address: Johan.elf@skane.se.
authors.forename: J
authors.initials: J
authors.lastname: Elf
authors.affiliation: Lund University, Department of Vascular Diseases, Skåne University Hospital, S-205 02 Malmö, Sweden. Electronic address: Anders.gottsater@med.lu.se.
authors.forename: A
authors.initials: A
authors.lastname: Gottsäter
authors.affiliation: Lund University, Department of Vascular Diseases, Skåne University Hospital, S-205 02 Malmö, Sweden. Electronic address: Stefan.acosta@med.lu.se.
authors.forename: S
authors.initials: S
authors.lastname: Acosta
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D065666:Mesenteric Ischemia / Q000175:diagnosis*; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D019851:Thrombophilia / Q000175:diagnosis*; D020246:Venous Thrombosis / Q000175:diagnosis*
keywords: Hypercoagulability; JAK2; Mesenteric venous thrombosis; Prothrombotic; Splanchnic vein thrombosis; Thrombophilia