title: Simultaneous Triple Imaging with Two PARASHIFT Probes: Encoding Anatomical, pH and Temperature Information using Magnetic Resonance Shift Imaging.
abstract: The chemical shift of paramagnetically shifted resonances in lanthanide(III) complexes encodes information about temperature and has also been made to report pH in parallel, through introduction of a single phosphonate group adjacent to the reporter tert-butyl resonance. The enhanced sensitivity of this new probe has allowed the simultaneous triple imaging of the water signal and the shifted tert-butyl signals of thulium and dysprosium complexes of a common ligand, separated by over 160 ppm. In parallel spectral imaging experiments, the temperature and pH dependence of the frequency of the Tm and Dy signals has been deconvoluted, allowing the pH and temperature in the liver, kidney and bladder to be measured.
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: Katie-Louise N A
authors.initials: KNA
authors.lastname: Finney
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: Alice C
authors.identifier: http://orcid.org/0000-0002-4092-705X
authors.initials: AC
authors.lastname: Harnden
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: Nicola J
authors.identifier: http://orcid.org/0000-0002-9604-5136
authors.initials: NJ
authors.lastname: Rogers
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: P Kanthi
authors.initials: PK
authors.lastname: Senanayake
authors.affiliation: Institute of Cellular Medicine and Newcastle MR Centre, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Blamire
authors.affiliation: Institute of Cellular Medicine and Newcastle MR Centre, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
authors.forename: Dara
authors.initials: D
authors.lastname: O'Hogain
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: David
authors.identifier: http://orcid.org/0000-0001-5281-5146
authors.initials: D
authors.lastname: Parker
keywords: MRI; imaging agents; lanthanides; spectral imaging; triple imaging