title: Secondary Conditions Among Males With Duchenne or Becker Muscular Dystrophy.
abstract: Duchenne and Becker muscular dystrophy are X-linked neuromuscular disorders characterized by progressive muscle degeneration. Despite the involvement of multiple systems, secondary conditions among affected males have not been comprehensively described. Two hundred nine caregivers of affected males (aged 3-31 years) identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network completed a mailed survey that included questions about secondary conditions impacting multiple body functions. The 5 most commonly reported conditions in males with Duchenne were cognitive deficits (38.4%), constipation (31.7%), anxiety (29.3%), depression (27.4%), and obesity (19.5%). Higher frequencies of anxiety, depression, and kidney stones were found among nonambulatory males compared to ambulatory males. Attention-deficit hyperactivity disorder (ADHD) was more common in ambulatory than nonambulatory males. These data support clinical care recommendations for monitoring of patients with Duchenne or Becker muscular dystrophy by a multidisciplinary team to prevent and treat conditions that may be secondary to the diagnosis.
authors.affiliation: 1 Cardiogenetic Testing Services, GeneDx, Gaithersburg, MD, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Latimer
authors.affiliation: 2 Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Street
authors.affiliation: 3 Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
authors.forename: Kristin Caspers
authors.initials: KC
authors.lastname: Conway
authors.affiliation: 4 University of Colorado, Denver, Aurora, CO, USA.
authors.forename: Kathy
authors.initials: K
authors.lastname: James
authors.affiliation: 5 Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Cunniff
authors.affiliation: 6 Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO, USA.
authors.forename: Joyce
authors.initials: J
authors.lastname: Oleszek
authors.affiliation: 7 New York State Department of Health, Albany, NY, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Fox
authors.affiliation: 8 University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Emma
authors.initials: E
authors.lastname: Ciafaloni
authors.affiliation: 7 New York State Department of Health, Albany, NY, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Westfield
authors.affiliation: 2 Division of Human Development and Disability, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Pangaja
authors.initials: P
authors.lastname: Paramsothy
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000453:epidemiology*; D015897:Comorbidity; D003248:Constipation / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology*; D006306:Health Surveys; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000453:epidemiology*; D009765:Obesity / Q000453:epidemiology*; D011159:Population Surveillance; D015995:Prevalence; D055815:Young Adult
keywords: Becker; Duchenne; comorbidities; muscular dystrophy; secondary conditions