title: Kisspeptin as a promising oocyte maturation trigger for in vitro fertilisation in humans.
abstract: The aim of this review is to analyse the effectiveness of exogenous kisspeptin administration as a novel alternative of triggering oocyte maturation, instead of currently used triggers such as human chorionic gonadotropin (hCG) or gonadotropin releasing hormone (GnRH) agonist, in women undergoing in vitro fertilisation (IVF) treatment. Kisspeptin has been considered a master regulator of two modes of GnRH and hence gonadotropin secretion, pulses and surges. Administration of kisspeptin-10 and kisspeptin-54 induces the luteinising hormone (LH) surge required for egg maturation and ovulation in animal investigations and LH release during the preovulatory phase of the menstrual cycle and hypothalamic amenorrhoea in humans. Exogenous kisspeptin-54 has been successfully administered as a promising method of triggering oocyte maturation, following ovarian stimulation with gonadotropins and GnRH antagonists in women undergoing IVF, due to its efficacy considering achieved pregnancy rates compared to hCG and GnRH agonists. Also, its safety in patients at high risk of developing ovarian hyperstimulation syndrome is noteworthy. Nevertheless, further studies would be desirable to establish the optimal trigger of egg maturation and to improve the reproductive outcome for women undergoing IVF treatment.
authors.affiliation: a Department of Obstetrics and Gynaecology , School of Medicine, University Hospital Centre Zagreb , Zagreb , Croatia.
authors.forename: Miro
authors.initials: M
authors.lastname: Kasum
authors.affiliation: a Department of Obstetrics and Gynaecology , School of Medicine, University Hospital Centre Zagreb , Zagreb , Croatia.
authors.forename: Daniela
authors.initials: D
authors.lastname: Franulić
authors.affiliation: b Department of Obstetrics and Gynaecology , Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina , and.
authors.forename: Ermin
authors.initials: E
authors.lastname: Čehić
authors.affiliation: a Department of Obstetrics and Gynaecology , School of Medicine, University Hospital Centre Zagreb , Zagreb , Croatia.
authors.forename: Slavko
authors.initials: S
authors.lastname: Orešković
authors.affiliation: c Gynaecology Cabinet, Kosovo Occupational Health Institute , Giakove , Kosovo.
authors.forename: Albert
authors.initials: A
authors.lastname: Lila
authors.affiliation: b Department of Obstetrics and Gynaecology , Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina , and.
authors.forename: Emina
authors.initials: E
authors.lastname: Ejubović
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D005307:Fertilization in Vitro / Q000009:adverse effects; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D059648:Kisspeptins / Q000009:adverse effects / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D009866:Oogenesis / Q000187:drug effects*; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control; D010060:Ovulation / Q000187:drug effects; D010062:Ovulation Induction / Q000009:adverse effects; D010446:Peptide Fragments / Q000009:adverse effects / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D012306:Risk
chemical_list: D005300:Fertility Agents, Female; C106628:KISS1 protein, human; D059648:Kisspeptins; D010446:Peptide Fragments; D011994:Recombinant Proteins
keywords: Exogenous administration; IVF; kisspeptin; oocyte maturation trigger; physiological mechanisms