title: Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury?
abstract: T2-weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At 1 month postinjury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at 1 month post-injury were associated with neurological and functional recovery at 1-year follow-up. Neuroimaging biomarkers of lesion size and midsagittal tissue bridges are potential outcome predictors and patient stratifiers in both subacute and chronic clinical trials. Ann Neurol 2017;81:740-748.
authors.affiliation: Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland.
authors.forename: Eveline
authors.identifier: http://orcid.org/0000-0002-7879-4192
authors.initials: E
authors.lastname: Huber
authors.affiliation: Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland.
authors.forename: Patrice
authors.initials: P
authors.lastname: Lachappelle
authors.affiliation: Radiology, Balgrist University Hospital, Zurich, Switzerland.
authors.forename: Reto
authors.initials: R
authors.lastname: Sutter
authors.affiliation: Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland.
authors.forename: Armin
authors.initials: A
authors.lastname: Curt
authors.affiliation: Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland.|Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom.|Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom.|Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Patrick
authors.identifier: http://orcid.org/0000-0002-4851-2246
authors.initials: P
authors.lastname: Freund
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D066193:Cervical Cord / Q000000981:diagnostic imaging / Q000293:injuries / Q000503:physiopathology; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D011782:Quadriplegia / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D015415:Biomarkers