title: The Feasibility Study of a Hybrid Coplanar Arc Technique Versus Hybrid Intensity-modulated Radiotherapy in Treatment of Early-stage Left-sided Breast Cancer with Simultaneous-integrated Boost.
abstract: This study demonstrated the feasibility and advantages of a hybrid, volumetric arc therapy technique that used two 90° coplanar arcs and two three-dimensional conformal tangential beams in the simultaneous-integrated boost radiotherapy of left-sided breast cancer after breast-conserving surgery. A total of nine patients with stage I, left-sided breast cancer who underwent breast-conserving surgery were selected for this retrospective study. For each patient, a hybrid arc plan was generated and then compared with two hybrid intensity-modulated radiotherapy plans. All plans were optimized using the same objectives and dose constraints. The prescription dose was 50.4 Gy to the planning target volume with simultaneous boost to 60 Gy to the expanded gross target volume in 28 fractions. The differences among these hybrid plans were analyzed by the Kolmogorov-Smirnov test or the Wilcoxon rank sum test. The hybrid arc plans achieved the clinical requirements of target dose coverage and normal tissue (NT) dose constraints. It was found that the hybrid arc plans showed advantages in the conformity index of the expanded gross target volume, the V5of the heart, the D2of the left ventricle, and the D2and V50.4of NTs. The average beam-on time and monitor units of the hybrid arc plans were significantly lower (P< 0.001).
authors.affiliation: Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: Yuan-Gui
authors.initials: YG
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: An-Chuan
authors.initials: AC
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: Wen-Yao
authors.initials: WY
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: Miao-Yun
authors.initials: MY
authors.lastname: Huang
authors.affiliation: Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: Ming-Qiu
authors.initials: MQ
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
authors.forename: Mutian
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
authors.forename: Ben-Hua
authors.initials: BH
authors.lastname: Xu
keywords: Breast cancer; hybrid treatment plan; simultaneous-integrated boost; whole breast irradiation