title: Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.
abstract: The potential impact of using human genetic data linked to longitudinal electronic medical records on drug development is extraordinary; however, the practical application of these data necessitates some organizational innovations. Vanderbilt has created resources such as an easily queried database of >2.6 million de-identified electronic health records linked to BioVU, which is a DNA biobank with more than 230,000 unique samples. To ensure these data are used to maximally benefit and accelerate both de novo drug discovery and drug repurposing efforts, we created the Accelerating Drug Development and Repurposing Incubator, a multidisciplinary think tank of experts in various therapeutic areas within both basic and clinical science as well as experts in legal, business, and other operational domains. The Incubator supports a diverse pipeline of drug indication finding projects, leveraging the natural experiment of human genetics.
authors.affiliation: 1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Pulley
authors.affiliation: 1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: Jana K
authors.initials: JK
authors.lastname: Shirey-Rice
authors.affiliation: 1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Lavieri
authors.affiliation: 1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: Rebecca N
authors.initials: RN
authors.lastname: Jerome
authors.affiliation: 1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Zaleski
authors.affiliation: 2 Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine , Nashville, Tennessee.|3 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: David M
authors.initials: DM
authors.lastname: Aronoff
authors.affiliation: 4 Department of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, Tennessee.
authors.forename: Lisa
authors.initials: L
authors.lastname: Bastarache
authors.affiliation: 4 Department of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, Tennessee.
authors.forename: Xinnan
authors.initials: X
authors.lastname: Niu
authors.affiliation: 1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.|5 Center for Technology Transfer and Commercialization, Vanderbilt University , Nashville, Tennessee.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Holroyd
authors.affiliation: 6 Office of Research, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: Dan M
authors.initials: DM
authors.lastname: Roden
authors.affiliation: 7 Department of Pathology, Microbiology, and Immunology, Division of Molecular Pathogenesis, Vanderbilt University School of Medicine , Nashville, Tennessee.
authors.forename: Eric P
authors.initials: EP
authors.lastname: Skaar
authors.affiliation: 8 Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee.|9 Vanderbilt Kennedy University Center for Excellence in Development Disabilities, Nashville, Tennessee.
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Niswender
authors.affiliation: 10 Department of Chemistry, Vanderbilt University , Nashville, Tennessee.|11 Department of Biochemistry, Vanderbilt University Medical School , Nashville Tennessee.
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Marnett
authors.affiliation: 10 Department of Chemistry, Vanderbilt University , Nashville, Tennessee.|12 Department of Medicinal Chemistry, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: Craig W
authors.initials: CW
authors.lastname: Lindsley
authors.affiliation: 1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.|13 Nashville Biosciences, Nashville, Tennessee.
authors.forename: Leeland B
authors.initials: LB
authors.lastname: Ekstrom
authors.affiliation: 5 Center for Technology Transfer and Commercialization, Vanderbilt University , Nashville, Tennessee.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Bentley
authors.affiliation: 1 Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center , Nashville, Tennessee.|6 Office of Research, Vanderbilt University Medical Center , Nashville, Tennessee.
authors.forename: Gordon R
authors.initials: GR
authors.lastname: Bernard
authors.affiliation: 14 Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine , Nashville, Tennessee.|15 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine , Nashville, Tennessee.
authors.forename: Charles C
authors.initials: CC
authors.lastname: Hong
authors.affiliation: 4 Department of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, Tennessee.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Denny
mesh_terms: D030541:Databases, Genetic; D015195:Drug Design; D058492:Drug Repositioning / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D000071185:Pharmacogenomic Testing / Q000379:methods*; D057285:Precision Medicine / Q000379:methods*
keywords: BioVU; PheWAS; genetics; repurposing; translational research