title: Importance of Metabolic Adaptations inFrancisellaPathogenesis.
abstract: Francisella tularensisis a highly infectious Gram-negative bacterium and the causative agent of the zoonotic disease tularemia. This bacterial pathogen can infect a broad variety of animal species and can be transmitted to humans in numerous ways with various clinical outcomes. Although,Francisellapossesses the capacity to infect numerous mammalian cell types, the macrophage constitutes the main intracellular niche, used forin vivobacterial dissemination. To survive and multiply within infected macrophages,Francisellamust imperatively escape from the phagosomal compartment. In the cytosol, the bacterium needs to control the host innate immune response and adapt its metabolism to this nutrient-restricted niche. Our laboratory has shown that intracellularFrancisellamainly relied on host amino acid as major gluconeogenic substrates and provided evidence that the host metabolism was also modified uponFrancisellainfection. We will review here our current understanding of howFrancisellacopes with the available nutrient sources provided by the host cell during the course of infection.
authors.affiliation: Sorbonne Paris Cité, Université Paris DescartesParis, France; Institut National de la Santé et de la Recherche Médicale U1151 - Centre National de la Recherche Scientifique UMR 8253, Institut Necker-Enfants Malades, Team 11: Pathogenesis of Systemic InfectionsParis, France.
authors.forename: Jason
authors.initials: J
authors.lastname: Ziveri
authors.affiliation: Sorbonne Paris Cité, Université Paris DescartesParis, France; Institut National de la Santé et de la Recherche Médicale U1151 - Centre National de la Recherche Scientifique UMR 8253, Institut Necker-Enfants Malades, Team 11: Pathogenesis of Systemic InfectionsParis, France.
authors.forename: Monique
authors.initials: M
authors.lastname: Barel
authors.affiliation: Sorbonne Paris Cité, Université Paris DescartesParis, France; Institut National de la Santé et de la Recherche Médicale U1151 - Centre National de la Recherche Scientifique UMR 8253, Institut Necker-Enfants Malades, Team 11: Pathogenesis of Systemic InfectionsParis, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Charbit
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D003600:Cytosol / Q000378:metabolism / Q000382:microbiology; D005603:Francisella / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D006019:Glycolysis; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology; D010588:Phagosomes / Q000378:metabolism / Q000382:microbiology; D014406:Tularemia / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D037521:Virulence Factors / Q000378:metabolism; D015047:Zoonoses / Q000382:microbiology
chemical_list: D000596:Amino Acids; D037521:Virulence Factors
keywords: Francisella tularensis; glycolysis; metabolism; nutrient uptake; virulence