title: Six new sesquiterpenoids from Nardostachys chinensis Batal.
abstract: Six new sesquiterpenoids, namely nardosinanones J-N and nardoaristolone C, were isolated from the rhizomes and roots of Nardostachys chinensis Batal. Their structures were determined by interpretation of spectroscopic data (HR-ESI-MS, 1D and 2D NMR). A combination of X-ray crystal diffraction, ECD calculation, and Mosher ester methods was employed to determine the absolute configuration of the isolated compounds. Compounds 1-2, 4-6 were evaluated anti-inflammatory activities in LPS-stimulated RAW264.7 macrophages. The results showed that compound 5 obviously inhibited LPS-induced iNOS and COX-2 protein expression compared to single LPS stimulation, which indicated the potential effect to medicate anti-inflammatory.
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
authors.forename: Xiu-Yu
authors.initials: XY
authors.lastname: Shen
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.affiliation: Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, People's Republic of China.
authors.forename: Jin-Fang
authors.initials: JF
authors.lastname: Luo
authors.affiliation: Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, People's Republic of China.
authors.forename: Yi-Han
authors.initials: YH
authors.lastname: Zuo
authors.affiliation: College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: tyaoxs@jnu.edu.cn.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: daiyi1004@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D051546:Cyclooxygenase 2 / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D032404:Nardostachys / Q000737:chemistry*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D000067996:RAW 264.7 Cells; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000893:Anti-Inflammatory Agents; D012717:Sesquiterpenes; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2
keywords: COX-2; Inflammatory; Nardostachys chinensis Batal; Sesquiterpenoids; iNOS