title: MicroRNAs as Biomarkers for Psychiatric Conditions: A Review of Current Research.
abstract: Neural-derived exosomes can be used as diagnostic markers to screen for various psychiatric conditions. These intravenously injected exosomes carry the potential to cross the blood brain barrier and deliver miRNA molecules specifically to neurons, microglia, and oligodendrocytes in the brain, resulting in specific gene knockdown. Here the authors review and discuss the current research on microRNA molecules and the therapeutic roles they may potentially play in treating depression, bipolar disorder, and schizophrenia.
authors.affiliation: Drs. Narahari, Hussain, and Sreeram are from the University of Alabama, Department of Psychiatry and Behavioral sciences, Birmingham, Alabama.
authors.forename: Anoop
authors.initials: A
authors.lastname: Narahari
authors.affiliation: Drs. Narahari, Hussain, and Sreeram are from the University of Alabama, Department of Psychiatry and Behavioral sciences, Birmingham, Alabama.
authors.forename: Mariyah
authors.initials: M
authors.lastname: Hussain
authors.affiliation: Drs. Narahari, Hussain, and Sreeram are from the University of Alabama, Department of Psychiatry and Behavioral sciences, Birmingham, Alabama.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Sreeram
keywords: MicroRNA (miR/miRNA); bipolar disorder; depression; hippocampus; messengerRNA (mRNA); neurogenesis; neuronal plasticity; schizophrenia