title: Synthesis of 1-indanones with a broad range of biological activity.
abstract: This comprehensive review describes methods for the preparation of 1-indanones published in original and patent literature from 1926 to 2017. More than 100 synthetic methods utilizing carboxylic acids, esters, diesters, acid chlorides, ketones, alkynes, alcohols etc. as starting materials, have been performed. This review also covers the most important studies on the biological activity of 1-indanones and their derivatives which are potent antiviral, anti-inflammatory, analgesic, antimalarial, antibacterial and anticancer compounds. Moreover, they can be used in the treatment of neurodegenerative diseases and as effective insecticides, fungicides and herbicides.
authors.affiliation: Institute of Chemistry, Environmental Protection and Biotechnology, The Faculty of Mathematics and Natural Sciences, Jan Długosz University in Częstochowa, Armii Krajowej 13/15, Częstochowa, 42-201, Poland.
authors.forename: Marika
authors.initials: M
authors.lastname: Turek
authors.affiliation: Department of Structural Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University of Łódź, Żeligowskiego 7/9, 90-752, Łódź, Poland; Department of Heteroorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, Łódź, 90-363, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Szczęsna
authors.affiliation: Department of Heteroorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, Łódź, 90-363, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Koprowski
authors.affiliation: Institute of Chemistry, Environmental Protection and Biotechnology, The Faculty of Mathematics and Natural Sciences, Jan Długosz University in Częstochowa, Armii Krajowej 13/15, Częstochowa, 42-201, Poland; Department of Heteroorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, Łódź, 90-363, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Bałczewski
keywords: 1-indanones; Diels–Alder reaction; Friedel–Crafts reaction; Nazarov reaction; biological activity