title: Biocompatible Shape Memory Blend for Self-Expandable Stents with Potential Biomedical Applications.
abstract: Biocompatible poly(propylene carbonate) (PPC)/polycaprolactone (PCL) shape memory blends were fabricated using melt blending. The shape memory performance of these blends was found to depend remarkably on their components. On addition of 25 vol % PCL, one blend (PL-25) achieved an optimal shape-fixing ratio (Rf) and -recovery ratio (Rr). Specifically, its Rrconsiderably increased by 24.1 and 50.0% compared with those of pure PPC and PCL, respectively, because of the restricted irreversible deformation of the amorphous chains cross-linked by tiny crystals. After undergoing three thermomechanical cycles, Rfand Rrreached 97.0%. The PL-25 blend was further melt-processed into a stent, which showed a fast response and self-expansion at 37 °C. These results, along with those obtained from evaluating the material's blood compatibility, in vitro degradation and drug release behavior, demonstrated the great potential of PL-25 for biomedical applications.
authors.affiliation: State Key Laboratory of Polymer Materials Engineering, Institute of Polymer Research, Sichuan University , Chengdu 610065, Sichuan, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University , Chengdu 610041, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Materials Engineering, Institute of Polymer Research, Sichuan University , Chengdu 610065, Sichuan, P. R. China.
authors.forename: Xue
authors.initials: X
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Polymer Materials Engineering, Institute of Polymer Research, Sichuan University , Chengdu 610065, Sichuan, P. R. China.
authors.forename: Jiabin
authors.identifier: http://orcid.org/0000-0002-6942-5686
authors.initials: J
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Polymer Materials Engineering, Institute of Polymer Research, Sichuan University , Chengdu 610065, Sichuan, P. R. China.
authors.forename: Shaoyun
authors.initials: S
authors.lastname: Guo
mesh_terms: D001672:Biocompatible Materials; D011091:Polyesters; D015607:Stents
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters
keywords: biodegradation; biomedical stent; blood compatibility; drug release; shape memory blend