title: Congenital Glioblastoma Multiforme: An Unusual and Challenging Tumor.
abstract: Congenital glioblastoma multiforme is a rare tumor of the central nervous system with unique features. The existing evidence on its pathogenesis, genetic and molecular profile, special characteristics, treatment, and prognosis is reviewed. An increased number of antenatal diagnoses and prolonged survival for those individuals who can tolerate combined surgical resection and chemotherapy has been noted. The overall prognosis, however, remains poor. A better understanding of this unusual entity is important. Further research is needed to discern tumor's pathogenesis and natural history. This will likely lead to the development and implementation of treatment strategies that may decrease mortality and morbidity in these patients.
authors.affiliation: Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece.
authors.forename: Dimitrios M
authors.initials: DM
authors.lastname: Anestis
authors.affiliation: Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece.
authors.forename: Parmenion P
authors.initials: PP
authors.lastname: Tsitsopoulos
authors.affiliation: Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Ble
authors.affiliation: Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom.
authors.forename: Vassilios
authors.initials: V
authors.lastname: Tsitouras
authors.affiliation: Department of Neurosurgery, Hippokratio General Hospital, Faculty of Medicine, Aristotle University of Thessaloniki School of Health Sciences, Thessaloniki, Greece.
authors.forename: Christos A
authors.initials: CA
authors.lastname: Tsonidis
mesh_terms: D016543:Central Nervous System Neoplasms / Q000151:congenital* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D005909:Glioblastoma / Q000151:congenital* / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans