title: Two new cytochalasan derivatives from Chaetomium globosum SNSHI-5, a fungus derived from extreme environment.
abstract: Two new cytochalasan derivatives, isochaetoglobosin Db(1) and cytoglobosin Ab(2), were isolated from an ethyl acetate extract of Chaetomium globosum SNSHI-5, a fungus derived from extreme environment. The structures of the new compounds were comprehensively characterized by HR-ESI-MS,1H NMR,13C NMR and 2D-NMR. Cytotoxic activity against H292 human lung cancer cell of the new compounds was tested. Isochaetoglobosin Db(1) showed potent cytotoxicity with IC50of 3.5 μM, while cytoglobosin Abwas inactive (IC50> 10 μM).
authors.affiliation: a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Shenyang , China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Wang
authors.affiliation: b Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yan
authors.affiliation: b Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Fang
authors.affiliation: b Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wu
authors.affiliation: a School of Pharmacy , Liaoning University of Traditional Chinese Medicine , Shenyang , China.|c China Democratic League , Chinese Shenyang Municipal Committee of Democratic League , Shenyang , China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: b Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences , Xiamen University , Xiamen , China.
authors.forename: Ying-Kun
authors.identifier: http://orcid.org/0000-0003-0181-2927
authors.initials: YK
authors.lastname: Qiu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000737:chemistry*; D003572:Cytochalasins / Q000302:isolation & purification*; D000071251:Extreme Environments; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003572:Cytochalasins
keywords: Chaetomium globosum SNSHI-5; cytochalasan derivatives; cytoglobosin Ab; cytotoxic activity; isochaetoglobosin Db