title: Synthesis of o-Methyl Trifluoromethyl Sulfide Substituted Benzophenones via 1,2-Difunctionalization of Aryne by Insertion into the C-C Bond.
abstract: An efficient process for the preparation of valuable o-methyl trifluoromethyl sulfide substituted benzophenones has been developed. The transition-metal-free method features insertion of aryne into a C-C σ-bond under mild reaction conditions for the first time to achieve ortho-difunctionalized arenes containing a pharmaceutically important trifluoromethylthio functional group. A wide substrate scope has been demonstrated for the developed protocol.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Milind M
authors.initials: MM
authors.lastname: Ahire
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Ruhima
authors.initials: R
authors.lastname: Khan
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411 008, India.
authors.forename: Santosh B
authors.identifier: 0000-0002-5859-0838
authors.initials: SB
authors.lastname: Mhaske