title: Breast Cancer Detected at Screening US: Survival Rates and Clinical-Pathologic and Imaging Factors Associated with Recurrence.
abstract: Purpose To determine the survival rates and clinical-pathologic and imaging factors associated with recurrence in women with breast cancer detected at screening ultrasonography (US). Materials and Methods This study was approved by the institutional review board, and the requirement to obtain informed consent was waived. A retrospective review of the databases of four institutions identified 501 women (median age, 47 years; range, 27-74 years) with breast cancer (425 invasive cancers and 76 ductal carcinoma in situ) detected at screening US between January 2004 and March 2011. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were estimated, and the clinical-pathologic and imaging data were collected. Multivariate analysis was performed by using Cox proportional hazard regression to determine factors associated with recurrence. Results At a median follow-up of 7.0 years (range, 5.0-12.1 years), 15 (3.0%) recurrences were detected: five in ipsilateral breast and 10 in contralateral breast. The 5-year OS and RFS rates were 100% and 98.0% (95% confidence interval [CI]: 96.8%, 99.2%), respectively. In patients with invasive cancers, age younger than 40 years (hazard ratio: 3.632 [95% CI: 1.099, 11.998]; P = .032), the triple-negative subtype (hazard ratio: 7.498 [95% CI: 2.266, 24.816]; P = .001), and Breast Imaging Reporting and Data System (BI-RADS) category 4A lesions (hazard ratio: 5.113 [95% CI: 1.532, 17.195]; P = .008) were associated with recurrence. Conclusion Women with breast cancers detected at screening US have excellent outcomes, with a 5-year RFS rate of 98.0%. However, in patients with invasive breast cancer, age younger than 40 years, the triple-negative subtype, and BI-RADS category 4A lesions were associated with recurrence.©RSNA, 2017 Online supplemental material is available for this article.
authors.affiliation: From the Department of Radiology (S.Y.K., W.K.M.) and Medical Research Collaborating Center (Y.C.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (B.K.H.); Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (E.K.K.); and Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (W.J.C., H.H.K.).
authors.forename: Soo-Yeon
authors.initials: SY
authors.lastname: Kim
authors.affiliation: From the Department of Radiology (S.Y.K., W.K.M.) and Medical Research Collaborating Center (Y.C.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (B.K.H.); Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (E.K.K.); and Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (W.J.C., H.H.K.).
authors.forename: Boo-Kyung
authors.initials: BK
authors.lastname: Han
authors.affiliation: From the Department of Radiology (S.Y.K., W.K.M.) and Medical Research Collaborating Center (Y.C.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (B.K.H.); Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (E.K.K.); and Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (W.J.C., H.H.K.).
authors.forename: Eun-Kyung
authors.initials: EK
authors.lastname: Kim
authors.affiliation: From the Department of Radiology (S.Y.K., W.K.M.) and Medical Research Collaborating Center (Y.C.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (B.K.H.); Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (E.K.K.); and Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (W.J.C., H.H.K.).
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Choi
authors.affiliation: From the Department of Radiology (S.Y.K., W.K.M.) and Medical Research Collaborating Center (Y.C.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (B.K.H.); Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (E.K.K.); and Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (W.J.C., H.H.K.).
authors.forename: Yunhee
authors.initials: Y
authors.lastname: Choi
authors.affiliation: From the Department of Radiology (S.Y.K., W.K.M.) and Medical Research Collaborating Center (Y.C.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (B.K.H.); Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (E.K.K.); and Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (W.J.C., H.H.K.).
authors.forename: Hak Hee
authors.initials: HH
authors.lastname: Kim
authors.affiliation: From the Department of Radiology (S.Y.K., W.K.M.) and Medical Research Collaborating Center (Y.C.), Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (B.K.H.); Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea (E.K.K.); and Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea (W.J.C., H.H.K.).
authors.forename: Woo Kyung
authors.initials: WK
authors.lastname: Moon
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016217:Ultrasonography, Mammary