title: Impact of sleep disordered breathing on short-term post-operative outcome after elective coronary artery bypass graft surgery: a prospective observational study.
abstract: Sleep disordered breathing (SDB) is common in patients with coronary disease, but its impact on post-operative recovery after coronary artery bypass graft surgery (CABG) is unclear. We therefore determined the effects of SDB on post-operative outcome after elective CABG.In this prospective two-centre study, 219 patients due to receive elective CABG underwent cardiorespiratory polygraphy for SDB prior to surgery and were monitored for post-operative complications. The primary end-point was a composite of 30-day mortality or major post-operative complications (cardiac, respiratory, surgical, infectious, acute renal failure or stroke). Key secondary end-points were single components of the primary end-point.SDB was present in 69% and moderate/severe SDB in 43% of the CABG patients. There was no difference in the composite of 30-day mortality or major postoperative complications between patients with and without SDB (OR 0.97, 95% CI 0.49-1.96) and between patients with moderate/severe SDB and no/mild SDB (OR 1.07, 95% CI 0.55-2.06). However, moderate/severe SDB was associated with higher rates of mortality (crude OR 10.1, 95% CI 1.22-83.5), sepsis (OR 2.96, 95% CI 1.17-7.50) and respiratory complications (OR 2.85, 95% CI 1.46-5.55).Although SDB was not associated with higher overall morbidity/mortality, moderate/severe SDB may increase the risk of death, and septic and respiratory complications, after elective CABG.
authors.affiliation: Hans-Berger Dept of Neurology, Jena University Hospital, Jena, Germany sven.rupprecht@med.uni-jena.de.|Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Rupprecht
authors.affiliation: Hans-Berger Dept of Neurology, Jena University Hospital, Jena, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Schultze
authors.affiliation: Dept of Neurology, Rotenburg Heart Centre, Rotenburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Nachtmann
authors.affiliation: Dept of Cardiothoracic Surgery, Rotenburg Heart Centre, Rotenburg, Germany.
authors.forename: Ardawan Julian
authors.initials: AJ
authors.lastname: Rastan
authors.affiliation: Dept of Cardiothoracic Surgery, Jena University Hospital, Jena, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Doenst
authors.affiliation: Hans-Berger Dept of Neurology, Jena University Hospital, Jena, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schwab
authors.affiliation: Hans-Berger Dept of Neurology, Jena University Hospital, Jena, Germany.
authors.forename: Otto W
authors.initials: OW
authors.lastname: Witte
authors.affiliation: Hans-Berger Dept of Neurology, Jena University Hospital, Jena, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Rohe
authors.affiliation: Hans-Berger Dept of Neurology, Jena University Hospital, Jena, Germany.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Zwacka
authors.affiliation: Institute of Medical Statistics, Information Sciences and Documentation, Jena University Hospital, Jena, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Hoyer
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000401:mortality*; D003324:Coronary Artery Disease / Q000401:mortality* / Q000601:surgery; D005260:Female; D005858:Germany / Q000453:epidemiology; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011446:Prospective Studies; D012891:Sleep Apnea Syndromes / Q000453:epidemiology*; D013997:Time Factors; D016896:Treatment Outcome