title: An Unchartered Journey for Ribosomes: Circumnavigating Circular RNAs to Produce Proteins.
abstract: In this issue of Molecular Cell, Legnini et al. (2017) and Pamudurti et al. (2017) demonstrate that endogenous circular RNAs may generate proteins, thereby expanding the eukaryotic proteome and revealing novel modes of cap-independent translation.
authors.affiliation: Department of Biochemistry & Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: Deirdre C
authors.initials: DC
authors.lastname: Tatomer
authors.affiliation: Department of Biochemistry & Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: wilusz@mail.med.upenn.edu.
authors.forename: Jeremy E
authors.initials: JE
authors.lastname: Wilusz
mesh_terms: D006801:Humans; D014176:Protein Biosynthesis; D011506:Proteins; D012333:RNA, Messenger; D012270:Ribosomes
chemical_list: D011506:Proteins; D012333:RNA, Messenger
keywords: IRES; backsplicing; cap-independent translation; circRNA; eIF3; m6A; polysome; pre-mRNA splicing; ribosome profiling; stress