title: Atypical cytologic presentation of a histiocytic sarcoma in a Cavalier King Charles Spaniel dog.
abstract: A Cavalier King Charles Spaniel dog was presented because of a 10-d history of progressive vomiting, inappetence, and lethargy, with mild neurologic signs. Fine-needle aspirates of splenic nodules seen on ultrasound were suggestive of a carcinoma. On autopsy, a disseminated neoplasm was present in the lung, spleen, and adrenal glands. Additionally, there was a Chiari-like malformation of the skull with corresponding syringomyelia of the cranial spinal cord. Histologically, the neoplasm was comprised of a pleomorphic population of round cells with a high mitotic rate. Cells stained positive for vimentin and CD18 and negative for cytokeratin, chromogranin A, CD3, CD20, MHC II, and CD11d, and hence the tumor was diagnosed as a histiocytic sarcoma. The cytologic presentation in this case is uncommon for this type of tumor, as was the clinical presentation.
authors.affiliation: Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA.
authors.forename: Lorelei L
authors.initials: LL
authors.lastname: Clarke
authors.affiliation: Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA.
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Kelly
authors.affiliation: Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA.
authors.forename: Bridget
authors.initials: B
authors.lastname: Garner
authors.affiliation: Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA.
authors.forename: Cathy A
authors.initials: CA
authors.lastname: Brown
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D054747:Histiocytic Sarcoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D014463:Ultrasonography
keywords: Adrenal gland; canine; cytology; histiocytic sarcoma