title: Decrease of global current source density predicts successful treatment in absence and juvenile myoclonic epilepsies.
abstract: To investigate relationship between treatment efficiency and EEG background activity changes in absence epilepsy (AE) and juvenile myoclonic epilepsy (JME) patients.
  
  
  
  EEGs of 31 patients were analysed before treatment and after six months of treatment. Three minutes of artifact-free waking EEG background activity (without epileptiform potentials) were analysed for each patient in both conditions. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography). Average of all the voxel-wise current source density (CSD) values within the 0.5-8.0Hz frequency range was computed for each EEG. Fischer's exact test was used to investigate association between the global CSD changes and the therapeutic outcome.
  
  
  
  Tight connection was demonstrated between seizure freedom and decreased CSD, and between persisting seizures and increased CSD (p<0.001).
  
  
  
  An EEG-based biomarker that predicts successful drug treatment was described.
authors.affiliation: Kenézy Gyula Hospital, Department of Neurology, Bartók Béla út 3., 4031 Debrecen, Hungary.
authors.forename: Johanna
authors.initials: J
authors.lastname: Dömötör
authors.affiliation: Kenézy Gyula Hospital, Department of Neurology, Bartók Béla út 3., 4031 Debrecen, Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Clemens
authors.affiliation: University of Debrecen, Medical Center, Department of Neurology, Móricz Zsigmond krt. 22., 4032 Debrecen, Hungary. Electronic address: szilvia.puskas@yahoo.com.
authors.forename: Szilvia
authors.initials: S
authors.lastname: Puskás
authors.affiliation: University of Debrecen, Medical Center, Department of Neurology, Móricz Zsigmond krt. 22., 4032 Debrecen, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Fekete
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D058256:Brain Waves / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000188:drug therapy* / Q000503:physiopathology; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants
keywords: Absence epilepsy; Current source density; EEG background activity; Myoclonic epilepsy; Treatment efficiency