title: Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Amyotrophic Lateral Sclerosis in a Patient Developing Carbon Dioxide Narcosis.
abstract: We report a rare case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) associated with amyotrophic lateral sclerosis (ALS). A 69-year-old man was admitted to our hospital with sustained hyponatremia. Hyposmolality with elevated urinary osmolality and sodium excretion was observed, which indicated SIADH. The treatment for SIADH was challenging; the patient developed carbon dioxide narcosis, which led to the diagnosis of ALS. After the initiation of noninvasive positive-pressure ventilation, the patient's serum sodium concentration normalized and became stable. Thus, ALS should be recognized as a possible cause of SIADH in the clinical setting.
authors.affiliation: Department of Internal Medicine, Osaka Red Cross Hospital, Japan.
authors.forename: Yui
authors.initials: Y
authors.lastname: Inoue
authors.forename: Takaaki
authors.initials: T
authors.lastname: Murakami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Kyohei
authors.initials: K
authors.lastname: Morita
authors.forename: Daita
authors.initials: D
authors.lastname: Kaneda
authors.forename: Ichizo
authors.initials: I
authors.lastname: Nishino
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yuya
authors.initials: Y
authors.lastname: Shinoto
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Hatoko
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kato
authors.forename: Shin
authors.initials: S
authors.lastname: Yonemitsu
authors.forename: Seiji
authors.initials: S
authors.lastname: Muro
authors.forename: Shogo
authors.initials: S
authors.lastname: Oki
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications*; D002245:Carbon Dioxide / Q000009:adverse effects*; D006801:Humans; D007010:Hyponatremia / Q000150:complications; D007177:Inappropriate ADH Syndrome / Q000150:complications*; D007222:Inert Gas Narcosis / Q000150:complications*; D008297:Male; D009994:Osmolar Concentration
chemical_list: D002245:Carbon Dioxide