title: Serial Casting as an Adjunct to Botulinum Toxin Type A Treatment in Children With Cerebral Palsy and Spastic Paraparesis With Scissoring of the Lower Extremities.
abstract: The purpose of this study was to examine whether combination therapy of serial casting and botulinum toxin type A injection can further enhance the effects of botulinum toxin type A in children with cerebral palsy with scissoring of both legs. This study was a prospective and randomized trial. The children were divided into 2 groups, one of which received serial casting after botulinum toxin type A (n = 40), and the other which only received botulinum toxin type A (n = 40). Serial casting started 3 weeks after the botulinum toxin type A. Both groups received physiotherapy. Groups were assessed at baseline then compared at 6 and 12 weeks following the intervention. Significant improvements in Gross Motor Function Measure-66 and Caregiver Health Questionnaire were recorded in both groups ( P < .001). The modified Ashworth scale improved significantly following botulinum toxin type A in the serial casting group ( P < .05), but not in botulinum toxin type A only group. These results suggest that serial casting after botulinum toxin type A can enhance the benefits of botulinum toxin type A in children with cerebral palsy.
authors.affiliation: 1 Department of Pediatric Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Alper I
authors.initials: AI
authors.lastname: Dai
authors.affiliation: 2 Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
authors.forename: Abdullah T
authors.initials: AT
authors.lastname: Demiryürek
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002370:Casts, Surgical; D002547:Cerebral Palsy / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D020336:Paraparesis, Spastic / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D016059:Range of Motion, Articular / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A
keywords: adductor muscles; botulinum toxin; cerebral palsy; scissoring; serial casting