title: A promising biodegradable magnesium alloy suitable for clinical vascular stent application.
abstract: We report a Mg alloy Mg-2.2Nd-0.1Zn-0.4Zr (wt.%, denoted as JDBM-2) showing great potential in clinical vascular stent application by integrating the advantages of traditional medical stainless steel and polymer. This alloy exhibits high yield strength and elongation of 276 ± 6 MPa and 34.3 ± 3.4% respectively. The JDBM-2 with a stable degradation surface results in a highly homogeneous degradation mechanism and long-term structural and mechanical durability. In vitro cytotoxicity test of the Mg extract via human vascular endothelial cells (HUVECs) indicates that the corrosion products are well tolerated by the tested cells and potentially negligible toxic effect on arterial vessel walls. This alloy also exhibits compromised foreign body response (FBR) determined by human peripheral blood derived macrophage adhesion, foreign body giant cell (FBGC) formation and inflammatory cytokine and chemokine secretion. Finally, vascular stents manufactured from the JDBM-2 were implanted into rabbits for long-term evaluation. The results confirm excellent tissue compatibility and up to 6-month structural and mechanical integrity of the stent in vivo. Thus, the JDBM-2 stent with up to 6-month structural and mechanical integrity and excellent tissue compatibility represents a major breakthrough in this field and a promising alternative to traditional medical stainless steel and polymer for the clinical application.
authors.affiliation: Shanghai Institute for Minimally Invasive Therapy, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.|National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China.|Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
authors.forename: Lin
authors.initials: L
authors.lastname: Mao
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Chen
authors.affiliation: School of Materials Science and Engineering, Nanjing Institute of Technology, Nanjing, 211167, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
authors.forename: Minsuk
authors.initials: M
authors.lastname: Kwak
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
authors.forename: Rong
authors.initials: R
authors.lastname: Fan
authors.affiliation: National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Pei
authors.affiliation: National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Guangyin
authors.initials: G
authors.lastname: Yuan
authors.affiliation: Shanghai Institute for Minimally Invasive Therapy, School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
authors.forename: Chengli
authors.initials: C
authors.lastname: Song
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
authors.affiliation: National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai, 200240, China.
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Ding
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000792:Angiography; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival; D002478:Cells, Cultured; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D055595:Mechanical Phenomena; D011817:Rabbits; D015607:Stents; D013499:Surface Properties
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D008274:Magnesium