title: Anti-pentraxin 3 auto-antibodies might be protective in lupus nephritis: a large cohort study.
abstract: OBJECTIVE
  Anti-pentraxin 3 (PTX3) auto-antibodies were found to be associated with the absence of renal involvement in systemic lupus erythematosus (SLE). This study is to investigate the prevalence of anti-PTX3 auto-antibodies and their clinical significance based on a large Chinese lupus nephritis cohort.
  
  
  METHODS
  One hundred and ninety-six active lupus nephritis patients, 150 SLE patients without clinical renal involvement, and 100 healthy controls were enrolled. Serum anti-PTX3 auto-antibodies and PTX3 levels were screened by enzyme-linked immunosorbent assay (ELISA). The associations between anti-PTX3 auto-antibodies and clinicopathological parameters in lupus nephritis were further analyzed.
  
  
  RESULTS
  Anti-PTX3 auto-antibodies were less prevalent in active lupus nephritis patients compared with SLE without renal involvement (19.4% (38/196) versus 40.7% (61/150), p < .001). The serum levels of anti-PTX3 auto-antibodies were negatively correlated with proteinuria in lupus nephritis (r = -.143, p = .047). The levels of proteinuria, serum creatinine, and the prevalence of thrombotic microangiopathy were significantly higher in patients with higher PTX3 levels (≥3.207 ng/ml) and without anti-PTX3 auto-antibodies compared with patients with lower PTX3 levels (<3.207 ng/ml) and with anti-PTX3 auto-antibodies (4.79 (3.39-8.28) versus 3.95 (1.78-7.0), p = .03; 168.84 ± 153.63 versus 101.44 ± 47.36, p = .01; 34.1% (14/41) versus 0% (0/9), p = .04; respectively).
  
  
  CONCLUSIONS
  Anti-PTX3 auto-antibodies were less prevalent in active lupus nephritis patients compared with SLE without renal involvement and associated with less severe renal damage, especially with the combined evaluation of serum PTX3 levels.
authors.affiliation: a Key laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Renal Division, Department of Medicine , Peking University First Hospital; Institute of Nephrology, Peking University , Beijing , PR China.
authors.forename: Mo
authors.initials: M
authors.lastname: Yuan
authors.affiliation: a Key laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Renal Division, Department of Medicine , Peking University First Hospital; Institute of Nephrology, Peking University , Beijing , PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Tan
authors.affiliation: a Key laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Renal Division, Department of Medicine , Peking University First Hospital; Institute of Nephrology, Peking University , Beijing , PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Pang
authors.affiliation: b Department of Rheumatology and Clinical Immunology , Peking Union Medical College Hospital; Chinese Academy of Medical Sciences & Peking Union Medical College; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education , Beijing , PR China.
authors.forename: Yong-Zhe
authors.initials: YZ
authors.lastname: Li
authors.affiliation: c Department of Nephrology , the First Affiliated Hospital of Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: a Key laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Renal Division, Department of Medicine , Peking University First Hospital; Institute of Nephrology, Peking University , Beijing , PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.affiliation: a Key laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Renal Division, Department of Medicine , Peking University First Hospital; Institute of Nephrology, Peking University , Beijing , PR China.|d Peking-Tsinghua Center for Life Sciences , Beijing , PR China.
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001706:Biopsy; D002097:C-Reactive Protein / Q000032:analysis / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007668:Kidney / Q000276:immunology*; D007677:Kidney Function Tests; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008181:Lupus Nephritis / Q000097:blood* / Q000276:immunology / Q000473:pathology; D008297:Male; D011507:Proteinuria / Q000097:blood / Q000276:immunology; D012189:Retrospective Studies; D000683:Serum Amyloid P-Component / Q000032:analysis / Q000276:immunology*; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D001323:Autoantibodies; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: Systemic lupus erythematosus; anti-pentraxin 3 auto-antibodies; lupus nephritis; pentraxin 3; renal damage