title: Increased Risk of Colorectal Cancer in Patients With Multiple Serrated Polyps and Their First-Degree Relatives.
abstract: We investigated whether patients with multiple serrated polyps, but not meeting the World Health Organization criteria for serrated polyposis syndrome, and their relatives have similar risks for colorectal cancer (CRC) as those diagnosed with serrated polyposis.
  
  
  
  We collected data from patients with more than 10 colonic polyps, recruited in 2008-2009 from 24 hospitals in Spain for a study of causes of multiple colonic polyps. We analyzed data from 53 patients who met the criteria for serrated polyposis and 145 patients who did not meet these criteria, but who had more than 10 polyps throughout the colon, of which more than 50% were serrated. We calculated age- and sex-adjusted standardized incidence ratios (SIRs) for CRC in both groups, as well as in their first-degree relatives.
  
  
  
  The prevalence of CRC was similar between patients with confirmed serrated polyposis and multiple serrated polyps (odds ratio, 1.35; 95% confidence interval [CI], 0.64-2.82; P = .40). The SIR for CRC in patients with serrated polyposis (0.51; 95% CI, 0.01-2.82) did not differ significantly from the SIR for CRC in patients with multiple serrated polyps (0.74; 95% CI, 0.20-1.90; P = .70). The SIR for CRC also did not differ significantly between first-degree relatives of these groups (serrated polyposis: 3.28, 95% CI, 2.16-4.77; multiple serrated polyps: 2.79, 95% CI, 2.10-3.63; P = .50). Kaplan-Meier analysis showed no differences in the incidence of CRC between groups during the follow-up period (log-rank, 0.6).
  
  
  
  The risk of CRC in patients with multiple serrated polyps who do not meet the criteria for serrated polyposis, and in their first-degree relatives, is similar to that of patients diagnosed with serrated polyposis.
authors.affiliation: Research Laboratory, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Egoavil
authors.affiliation: Research Laboratory, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Juárez
authors.affiliation: Research Laboratory, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Guarinos
authors.affiliation: Service of Digestive Medicine, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Rodríguez-Soler
authors.affiliation: Research Laboratory, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Hernández-Illán
authors.affiliation: Pathology Department, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Alenda
authors.affiliation: Pathology Department, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: Artemio
authors.initials: A
authors.lastname: Payá
authors.affiliation: Molecular Genetics Laboratory, Elche University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: Adela
authors.initials: A
authors.lastname: Castillejo
authors.affiliation: Institut de Malaties Digestives i Metabòliques, CIBERehd, Hospital Clínic, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Serradesanferm
authors.affiliation: Gastroenterology Department, Hospital Donostia, Centros de Investigación Biomédica en Red de enfermedades hepáticas y digestivas, Universidad del País Vasco, San Sebastián, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Bujanda
authors.affiliation: Gastroenterology Department, Hospital Mútua de Terrassa, Terrassa, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernández-Bañares
authors.affiliation: Gastroenterology Department, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Cubiella
authors.affiliation: Gastroenterology Department, Complexo Hospitalario de Vigo, Vigo, Spain.
authors.forename: Luisa
authors.initials: L
authors.lastname: de-Castro
authors.affiliation: Gastroenterology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Guerra
authors.affiliation: Oncology Department, Hospital Arnau de Vilanova, Lleida, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Aguirre
authors.affiliation: Gastroenterology Department, Hospital Puerta de Hierro, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Herreros-de-Tejada
authors.affiliation: Gastroenterology Department, Hospital del Mar Medical Research Institute, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Bessa
authors.affiliation: Gastroenterology Department, Clínica Universitaria de Navarra, Pamplona, Spain.
authors.forename: Maite
authors.initials: M
authors.lastname: Herráiz
authors.affiliation: Gastroenterology Department, Hospital 12 de Octubre, Madrid, Spain.
authors.forename: José-Carlos
authors.initials: JC
authors.lastname: Marín-Gabriel
authors.affiliation: Oncology Department, Hospital Vall d'Hebrón, Barcelona, Spain.
authors.forename: Judith
authors.initials: J
authors.lastname: Balmaña
authors.affiliation: Gastroenterology Department, Hospital Universitari Dr. Josep Trueta, Girona, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Piñol
authors.affiliation: Gastroenterology Department, Hospital Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Rodríguez Moranta
authors.affiliation: Gastroenterology Department, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Nicolás-Pérez
authors.affiliation: Pathology Department, Hospital Clínic, Barcelona, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Cuatrecasas
authors.affiliation: Institut de Malaties Digestives i Metabòliques, CIBERehd, Hospital Clínic, Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Balaguer
authors.affiliation: Institut de Malaties Digestives i Metabòliques, CIBERehd, Hospital Clínic, Barcelona, Spain.
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
authors.affiliation: Molecular Genetics Laboratory, Elche University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Soto
authors.affiliation: Clinical Pharmacology Department, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Zapater
authors.affiliation: Research Laboratory, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain; Service of Digestive Medicine, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research Instituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain. Electronic address: rodrigojover@gmail.com.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Jover
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D000368:Aged; D003111:Colonic Polyps / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D045647:DNA Glycosylases / Q000235:genetics; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree; D011159:Population Surveillance; D015995:Prevalence; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D012307:Risk Factors; D013577:Syndrome; D047368:Tumor Burden
chemical_list: C117307:KRAS protein, human; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D045647:DNA Glycosylases; C061738:mutY adenine glycosylase; D016283:Proto-Oncogene Proteins p21(ras)
keywords: Cancer Risk; Colon Cancer; SPS; Surveillance