title: Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings.
abstract: The present study is focused on the synthesis, characterization and antifungal evaluation of zinc-doped hydroxyapatite (Zn:HAp) coatings. The Zn:HAp coatings were deposited on a pure Si (Zn:HAp_Si) and Ti (Zn:HAp_Ti) substrate by a sol-gel dip coating method using a zinc-doped hydroxyapatite nanogel. The nature of the crystal phase was determined by X-ray diffraction (XRD). The crystalline phase of the prepared Zn:HAp composite was assigned to hexagonal hydroxyapatite in the P63/mspace group. The colloidal properties of the resulting Zn:HAp (xZn= 0.1) nanogel were analyzed by Dynamic Light Scattering (DLS) and zeta potential. Scanning Electron Microscopy (SEM) was used to investigate the morphology of the zinc-doped hydroxyapatite (Zn:HAp) nanogel composite and Zn:HAp coatings. The elements Ca, P, O and Zn were found in the Zn:HAp composite. According to the EDX results, the degree of Zn substitution in the structure of Zn:HAp composite was 1.67 wt%. Moreover, the antifungal activity of Zn:HAp_Si and Zn:HAp_Ti againstCandida albicans(C. albicans) was evaluated. A decrease in the number of surviving cells was not observed under dark conditions, whereas under daylight and UV light illumination a major decrease in the number of surviving cells was observed.
authors.affiliation: National Institute of Materials Physics, Atomistilor Street, No. 105 bis, P.O. Box MG 07, 077125 Magurele, Romania. simonaiconaru@gmail.com.
authors.forename: Simona Liliana
authors.initials: SL
authors.lastname: Iconaru
authors.affiliation: Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, Sector 1, 014461 Bucharest, Romania. prodan1084@gmail.com.|Surgery Department, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, Romania. prodan1084@gmail.com.
authors.forename: Alina Mihaela
authors.initials: AM
authors.lastname: Prodan
authors.affiliation: HORIBA Jobin Yvon S.A.S., 6-18, rue du Canal, 91165 Longjumeau CEDEX, France. nicolas.buton@horiba.com.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Buton
authors.affiliation: National Institute of Materials Physics, Atomistilor Street, No. 105 bis, P.O. Box MG 07, 077125 Magurele, Romania. dpredoi@gmail.com.
authors.forename: Daniela
authors.initials: D
authors.lastname: Predoi
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D015032:Zinc
keywords: C. albicans; hydroxyapatite; thin layer; zinc