title: Mesenchymal Stem Cell-Derived Exosomes: Immunomodulatory Evaluation in an Antigen-Induced Synovitis Porcine Model.
abstract: Synovitis is an inflammatory process associated with pain, disability, and discomfort, which is usually treated with anti-inflammatory drugs or biological agents. Mesenchymal stem cells (MSCs) have been also successfully used in the treatment of inflammatory-related diseases such as synovitis or arthritis. In the last years, the exosomes derived from MSCs have become a promising tool for the treatment of inflammatory-related diseases and their therapeutic effect is thought to be mediated (at least in part) by their immunomodulatory potential. In this work, we aimed to evaluate the anti-inflammatory effect of these exosomes in an antigen-induced synovitis animal model. To our knowledge, this is the first report where exosomes derived from MSCs have been evaluated in an animal model of synovitis. Our results demonstrated a decrease of synovial lymphocytes together with a downregulation of TNF-α transcripts in those exosome-treated joints. These results support the immunomodulatory effect of these exosomes and point out that they may represent a promising therapeutic option for the treatment of synovitis.
authors.affiliation: Stem Cell Therapy Unit, "Jesús Usón" Minimally Invasive Surgery Centre, Cáceres, Spain; Immunology Unit, Department of Physiology, University of Extremadura, Cáceres, Spain; CIBER de Enfermedades Cardiovasculares, Cáceres, Spain.
authors.forename: Javier G
authors.initials: JG
authors.lastname: Casado
authors.affiliation: Stem Cell Therapy Unit, "Jesús Usón" Minimally Invasive Surgery Centre, Cáceres, Spain; CIBER de Enfermedades Cardiovasculares, Cáceres, Spain.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Blázquez
authors.affiliation: Stem Cell Therapy Unit, "Jesús Usón" Minimally Invasive Surgery Centre , Cáceres , Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Vela
authors.affiliation: Stem Cell Therapy Unit, "Jesús Usón" Minimally Invasive Surgery Centre , Cáceres , Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Álvarez
authors.affiliation: Immunology Unit, Department of Physiology, University of Extremadura , Cáceres , Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Tarazona
authors.affiliation: Stem Cell Therapy Unit, "Jesús Usón" Minimally Invasive Surgery Centre, Cáceres, Spain; CIBER de Enfermedades Cardiovasculares, Cáceres, Spain.
authors.forename: Francisco Miguel
authors.initials: FM
authors.lastname: Sánchez-Margallo
keywords: exosomes; immunomodulation; inflammation; mesenchymal stem cells; synovitis