title: Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial.
abstract: Background:There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fits-all advice.Objective:We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition.Design:A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group.FTO(single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of theFTOgene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6.Results:Changes in adiposity markers were greater in participants who were informed that they carried theFTOrisk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight and WC at month 6 were greater forFTOrisk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P= 0.037); and -4.34 cm (-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P= 0.048)].Conclusions:There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of theFTOgene. This trial was registered at clinicaltrials.gov as NCT01530139.
authors.affiliation: Human Nutrition Research Center, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.|Glasgow Cardiovascular Research Center, Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, United Kingdom.
authors.forename: Carlos
authors.identifier: 0000-0003-2612-3917
authors.initials: C
authors.lastname: Celis-Morales
authors.affiliation: Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, Netherlands.
authors.forename: Cyril Fm
authors.initials: CF
authors.lastname: Marsaux
authors.affiliation: Human Nutrition Research Center, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Livingstone
authors.affiliation: Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Navas-Carretero
authors.affiliation: Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: San-Cristobal
authors.affiliation: Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Fallaize
authors.affiliation: Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom.
authors.forename: Anna L
authors.initials: AL
authors.lastname: Macready
authors.affiliation: University College Dublin (UCD) Institute of Food and Health, UCD, Dublin, Ireland.
authors.forename: Clare
authors.initials: C
authors.lastname: O'Donovan
authors.affiliation: University College Dublin (UCD) Institute of Food and Health, UCD, Dublin, Ireland.
authors.forename: Clara
authors.initials: C
authors.lastname: Woolhead
authors.affiliation: University College Dublin (UCD) Institute of Food and Health, UCD, Dublin, Ireland.
authors.forename: Hannah
authors.initials: H
authors.lastname: Forster
authors.affiliation: Research Center of Nutrition and Food Sciences (ZIEL), Biochemistry Unit, Technical University of Munich, Munich, Germany.
authors.forename: Silvia
authors.initials: S
authors.lastname: Kolossa
authors.affiliation: Research Center of Nutrition and Food Sciences (ZIEL), Biochemistry Unit, Technical University of Munich, Munich, Germany.
authors.forename: Hannelore
authors.initials: H
authors.lastname: Daniel
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Moschonis
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Mavrogianni
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Yannis
authors.initials: Y
authors.lastname: Manios
authors.affiliation: National Food and Nutrition Institute, Warsaw, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Surwillo
authors.affiliation: National Food and Nutrition Institute, Warsaw, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Traczyk
authors.affiliation: Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Christian A
authors.initials: CA
authors.lastname: Drevon
authors.affiliation: Eurogenetica Ltd, Burnham-on-Sea, United Kingdom; and.
authors.forename: Keith
authors.initials: K
authors.lastname: Grimaldi
authors.affiliation: Netherlands Organization for Applied Scientific Research (TNO), Microbiology and Systems Biology Group, Zeist, Netherlands.
authors.forename: Jildau
authors.initials: J
authors.lastname: Bouwman
authors.affiliation: University College Dublin (UCD) Institute of Food and Health, UCD, Dublin, Ireland.
authors.forename: Mike J
authors.initials: MJ
authors.lastname: Gibney
authors.affiliation: University College Dublin (UCD) Institute of Food and Health, UCD, Dublin, Ireland.
authors.forename: Marianne C
authors.initials: MC
authors.lastname: Walsh
authors.affiliation: University College Dublin (UCD) Institute of Food and Health, UCD, Dublin, Ireland.
authors.forename: Eileen R
authors.initials: ER
authors.lastname: Gibney
authors.affiliation: University College Dublin (UCD) Institute of Food and Health, UCD, Dublin, Ireland.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Brennan
authors.affiliation: Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Lovegrove
authors.affiliation: Department of Nutrition, Food Science and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain.
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martinez
authors.affiliation: Department of Human Biology, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, Netherlands.
authors.forename: Wim Hm
authors.initials: WH
authors.lastname: Saris
authors.affiliation: Human Nutrition Research Center, Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom; john.mathers@ncl.ac.uk.
authors.forename: John C
authors.identifier: 0000-0003-3406-3002
authors.initials: JC
authors.lastname: Mathers
mesh_terms: D000273:Adipose Tissue; D050154:Adiposity / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000483:Alleles; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO / Q000235:genetics*; D001835:Body Weight / Q000235:genetics; D030881:Disclosure; D005060:Europe; D005260:Female; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005838:Genotype; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055105:Waist Circumference; D015431:Weight Loss; D055815:Young Adult
chemical_list: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: FTO; genotype; personalized nutrition; randomized controlled trial; weight