title: [Acute glomerulonephritis with hemodialysis requirement secondary to influenza A H1N1pdm09 infection: Report of two cases].
abstract: Acute renal failure (ARF) requiring hemodialysis is not common among patients affected by influenza. We report two unvaccinated adult patients with smoking habit, which were admitted with severe influenza A H1N1pdm09 that evolved with shock and required mechanical ventilation. Both patients developed progressive renal failure with oliguria/anuria, associated with urinary of inflammatory sediment with proteinuria, microhematuria and in one case also with hypocomplementemia, suggesting acute glomerulonephritis. Renal replacement therapy (RRT) was required in both cases. In one patient, who died of late complications, sequencing of the HA1 segment revealed the previously described D222N mutation associated to severe cases. ARF with RRT appears to be an uncommon complication of patients hospitalized for influenza A H1N1pdm09 and may be secondary to acute glomerulonephritis.
authors.affiliation: Escuela de Medicina, Universidad de los Andes, Chile.
authors.forename: Diana
authors.initials: D
authors.lastname: Aceituno
authors.affiliation: Servicio de Infectología, Hospital Militar, Santiago, Chile.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fica
authors.affiliation: Sección Virus Respiratorios y Exantemáticos, Subdepartamento de Enfermedades Virales, Instituto de Salud Pública de Chile, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Fasce
authors.forename: Winston
authors.initials: W
authors.lastname: Andrade
authors.affiliation: Servicio de Nefrología, Hospital Militar, Santiago, Chile.
authors.forename: Carolina
authors.initials: C
authors.lastname: Díaz
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000628:therapy / Q000821:virology*; D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy / Q000821:virology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis