title: Complexity analysis of fNIRS signals in ADHD children during working memory task.
abstract: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children. Neuroimaging studies have revealed abnormalities of neural activities in some brain regions, including the frontal cortex, striatum, cerebellum, and occipital cortex. Recently, some investigators have demonstrated that nonlinear complexity analysis of neural activity may provide a new index to indicate ADHD. In the present study, we used the permutation entropy (PE) to measure the complexity of functional near-infrared spectroscopy (fNIRS) signals in children with and without ADHD during a working memory task, it was aimed to investigate the relationship between the PE values and the cortical activations, and the different PE values between the children with and without ADHD. We found that PE values exhibited significantly negative correlation with the cortical activations (r = -0.515, p = 0.003), and the PE values of right dorsolateral prefrontal cortex in ADHD children were significantly larger than those in normal controls (p = 0.027). In addition, the PE values of right dorsolateral prefrontal cortex were positively correlated to the ADHD index (r = 0.448, p = 0.012). These results suggest that complexity analysis of fNIRS signals could be a promising tool in diagnosing children with ADHD.
authors.affiliation: Institute of Electrical Engineering, Yanshan University, No. 438, Hebei Street, HaiGang District, Qinhuangdao, 066004, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Children's Hospital Attached to The Capital Institute of Paediatrics, No. 2, Yabao Street, ChaoYang District, Beijing, 100020, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Miao
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19, Xinjiekou Wai Street, Haidian District, Beijing, 100875, China.
authors.forename: Junxia
authors.initials: J
authors.lastname: Han
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19, Xinjiekou Wai Street, Haidian District, Beijing, 100875, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19, Xinjiekou Wai Street, Haidian District, Beijing, 100875, China.
authors.forename: Gaoxiang
authors.initials: G
authors.lastname: Ouyang
authors.affiliation: Children's Hospital Attached to The Capital Institute of Paediatrics, No. 2, Yabao Street, ChaoYang District, Beijing, 100020, China. yangjian1306@sina.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, No. 19, Xinjiekou Wai Street, Haidian District, Beijing, 100875, China. xiaoli@bnu.edu.cn.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Li
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019265:Spectroscopy, Near-Infrared / Q000379:methods*