title: Vitamin D requirements in infancy: a systematic review.
abstract: OBJECTIVE
  New evidence for recommendations for vitamin D supplementation in healthy infants based upon recent literature.
  
  
  RESULTS
  Randomized controlled trials published since 2009 that related to vitamin D doses in infancy were reviewed. They do not provide any additional evidence that larger, more generous amounts of daily vitamin D beyond the customary recommended 400 IU daily dose, affect any significant outcome. Larger amounts may lead to serum 25 hydroxy vitamin D concentrations that have been reported to be potentially associated with adverse effects.
  
  
  CONCLUSIONS
  There are still many unanswered questions left, in particular whether or not more 'generous' amounts of vitamin D in infancy may improve long-term health outcomes such as prevention of osteoporosis, allergies, or cancer.
authors.affiliation: aDepartment of Neonatology, Shaare Zedek Medical Center, Jerusalem bSackler Faculty of Medicine, Tel Aviv University cPediatric Department dPediatric Gastroenterology Unit, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center Tel Aviv, Israel.
authors.forename: Francis B
authors.initials: FB
authors.lastname: Mimouni
authors.forename: Adi
authors.initials: A
authors.lastname: Huber-Yaron
authors.forename: Shlomi
authors.initials: S
authors.lastname: Cohen
mesh_terms: D019587:Dietary Supplements; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D009751:Nutritional Requirements; D009752:Nutritional Status; D016032:Randomized Controlled Trials as Topic; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000097:blood / Q000628:therapy; D014815:Vitamins / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D