title: Major clinical research advances in gynecologic cancer in 2016: 10-year special edition.
abstract: In 2016, 13 topics were selected as major research advances in gynecologic oncology. For ovarian cancer, study results supporting previous ones regarding surgical preventive strategies were reported. There were several targeted agents that showed comparable responses in phase III trials, including niraparib, cediranib, and nintedanib. On the contrary to our expectations, dose-dense weekly chemotherapy regimen failed to prove superior survival outcomes compared with conventional triweekly regimen. Single-agent non-platinum treatment to prolong platinum-free-interval in patients with recurrent, partially platinum-sensitive ovarian cancer did not improve and even worsened overall survival (OS). For cervical cancer, we reviewed robust evidences of larger-scaled population-based study and cost-effectiveness of nonavalent vaccine for expanding human papillomavirus (HPV) vaccine coverage. Standard of care treatment of locally advanced cervical cancer (LACC) was briefly reviewed. For uterine corpus cancer, new findings about appropriate surgical wait time from diagnosis to surgery were reported. Advantages of minimally invasive surgery over conventional laparotomy were reconfirmed. There were 5 new gene regions that increase the risk of developing endometrial cancer. Regarding radiation therapy, Post-Operative Radiation Therapy in Endometrial Cancer (PORTEC)-3 quality of life (QOL) data were released and higher local control rate of image-guided adaptive brachytherapy was reported in LACC. In addition, 4 general oncology topics followed: chemotherapy at the end-of-life, immunotherapy with reengineering T-cells, actualization of precision medicine, and artificial intelligence (AI) to make personalized cancer therapy real. For breast cancer, adaptively randomized trials, extending aromatase inhibitor therapy, and ribociclib and palbociclib were introduced.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Dong Hoon
authors.identifier: http://orcid.org/0000-0002-4312-966X
authors.initials: DH
authors.lastname: Suh
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Miseon
authors.identifier: http://orcid.org/0000-0002-5118-9275
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Kidong
authors.identifier: http://orcid.org/0000-0001-9254-6024
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hak Jae
authors.identifier: http://orcid.org/0000-0003-3602-2263
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
authors.forename: Kyung Hun
authors.identifier: http://orcid.org/0000-0002-2390-3240
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. kjwksh@snu.ac.kr.
authors.forename: Jae Weon
authors.identifier: http://orcid.org/0000-0003-1835-9436
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D035843:Biomedical Research / Q000639:trends*; D001918:Brachytherapy / Q000639:trends; D001943:Breast Neoplasms / Q000628:therapy; D016889:Endometrial Neoplasms / Q000628:therapy; D005260:Female; D005833:Genital Neoplasms, Female / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D058990:Molecular Targeted Therapy; D010051:Ovarian Neoplasms / Q000628:therapy; D057285:Precision Medicine; D011878:Radiotherapy / Q000639:trends; D061089:Radiotherapy, Image-Guided / Q000639:trends; D013727:Terminal Care; D002583:Uterine Cervical Neoplasms / Q000628:therapy; D014594:Uterine Neoplasms / Q000628:therapy
keywords: Artificial Intelligence; Breast Neoplasms; Genital Neoplasms, Female; Ovarian Neoplasms; Precision Medicine