title: Psychological profiles in patients with symptomatic reticular forms of oral lichen planus: A prospective cohort study.
abstract: OBJECTIVE
  To analyze intra, extra-oral symptoms and psychological profiles in symptomatic patients with reticular (R) forms of oral lichen planus (OLP).
  
  
  METHODS
  Thirty symptomatic R-OLP (sR-OLP) patients were compared with an equal number of non-symptomatic R-OLP (nsR-OLP) patients, burning mouth syndrome (BMS) patients, and healthy subjects (HS). The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), and the Hamilton Rating Scales for Depression (HAM-D) and Anxiety (HAM-A) were administered. Descriptive statistics, the non-parametric ANOVA procedure by Kruskal-Wallis, the exact Fisher test, and the multiple comparison test by the Mann-Whitney U test were performed.
  
  
  RESULTS
  The median and IQR of the HAM-D and HAM-A were 16.0 (11.7-24.0) and 17.5 (13.7-27.2) for the BMS, 13.5 (12.0-15.0) and 15.5 (10.7-18.0) for the sR-OLP patients, 2.0 (2.0-3.2) and 2.0 (2.0-4.0) for the nsR-OLP patients, and 3.0 (2.0-4.0) and 3.0 (2.0-4.0) for the HS, respectively. The median and IQR of the NRS and T-PRI were 9.0 (7.7-10.0) and 11.0 (9.0-12.2) for the BMS and 9.0 (7.7-10.0) and 11.5 (7.0-13.0) for the sR-OLP patients, respectively. Comparison analysis between the BMS and sR-OLP patients revealed a non-significant difference between the medians of the psychological profile and pain in the two groups (P-value>.05).
  
  
  CONCLUSIONS
  The oral complaints are correlated with anxious and depressive symptoms in sR-OLP patients. Mood disorders could modulate the pain perception or that patients could develop two different associated oral diseases, OLP and BMS.
authors.affiliation: University Federico II of Naples, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Naples, Italy.
authors.forename: Daniela
authors.identifier: http://orcid.org/0000-0002-3784-4229
authors.initials: D
authors.lastname: Adamo
authors.affiliation: University Federico II of Naples, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Naples, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Cascone
authors.affiliation: Melbourne Dental School, University of Melbourne, Carlton, Vic, Australia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Celentano
authors.affiliation: University Federico II of Naples, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Naples, Italy.
authors.forename: Elvira
authors.initials: E
authors.lastname: Ruoppo
authors.affiliation: University Federico II of Naples, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Naples, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Leuci
authors.affiliation: Department of Economics and Statistics, University Federico II of Naples, Naples, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Aria
authors.affiliation: University Federico II of Naples, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Naples, Italy.
authors.forename: Michele D
authors.initials: MD
authors.lastname: Mignogna
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000175:diagnosis / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
keywords: anxiety; burning mouth syndrome; depression; oral burning; oral lichen planus; pain