title: CYP1B1 G199T Polymorphism Affects Prognosis of NSCLC Patients with the Potential to Be an Indicator and Target for Precise Drug Intervention.
abstract: CYP1B1 gene single nucleotide polymorphisms G119T, C432G, and A453G were tested among 164 NSCLC patients treated by Video-Assisted Thoracoscopic Surgery. After a follow-up period of 5 years, it was found that CYP1B1 G119T mutant genotypes were related to a higher risk of tumor recurrence and death after surgical resection. However, C432G and A453G genotypes had no influence on long-term prognosis of the study cohort. Thus, G199T alleles are supposed to be an auxiliary predictor for prognosis of NSCLC patients and a potential target for precise drug intervention, as well as a candidate for further anticancer drug research.
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China; Lung Cancer Diagnosis and Treatment Center, Dalian, Liaoning 116011, China.
authors.forename: Fengzhou
authors.identifier: 0000-0002-4902-2820
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Xingtai People's Hospital, Xingtai, Hebei 054031, China.
authors.forename: Shaofeng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: China National Research Institute of Food & Fermentation Industries, Beijing 100015, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Lung Cancer Diagnosis and Treatment Center, Dalian, Liaoning 116011, China.
authors.forename: Jinxiu
authors.identifier: 0000-0001-7303-1498
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China; Lung Cancer Diagnosis and Treatment Center, Dalian, Liaoning 116011, China.
authors.forename: Shilei
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Thoracic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China; Lung Cancer Diagnosis and Treatment Center, Dalian, Liaoning 116011, China.
authors.forename: Chundong
authors.identifier: 0000-0002-2981-6578
authors.initials: C
authors.lastname: Gu
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D065633:Cytochrome P-450 CYP1B1 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1