title: The menopausal hot flush: a review.
abstract: The hot flush is the most characteristic and often the most distressing symptom of the menopause. It is a unique feature and yet the mechanism and health implications are still not fully understood. This review summarizes some of the current thoughts on factors contributing to flushing, the physiological, vascular and neuroendocrine changes associated with flushing and the possible cardiovascular and other health implications for women experiencing hot flushes. Therapy is not discussed.
authors.affiliation: a Department of Gynaecology , Solihull Hospital , Birmingham , UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Sturdee
authors.affiliation: b Unit of Psychology , Institute of Psychiatry (at Guy's), King's College London , London , UK.
authors.forename: M S
authors.initials: MS
authors.lastname: Hunter
authors.affiliation: c Department of Psychiatry , University of Illinois at Chicago , Chicago , IL , USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Maki
authors.affiliation: d Women's Unit , Solihull Hospital, Birmingham Heartlands & Solihull NHS Trust , Birmingham , UK.
authors.forename: P
authors.initials: P
authors.lastname: Gupta
authors.affiliation: e Department of Obstetrics & Gynaecology , University of Glasgow, College of Medicine, Western Infirmary , Glasgow , UK.
authors.forename: J
authors.initials: J
authors.lastname: Sassarini
authors.affiliation: f National Heart & Lung Institute, Royal Brompton Hospital , London , UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Stevenson
authors.affiliation: g Reproductive and Maternal Medicine , University of Glasgow , Glasgow , UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Lumsden
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation; D001921:Brain / Q000503:physiopathology; D002318:Cardiovascular Diseases; D004967:Estrogens / Q000172:deficiency; D005260:Female; D019584:Hot Flashes / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008568:Memory; D008593:Menopause / Q000502:physiology; D009490:Neurosecretory Systems / Q000503:physiopathology; D010053:Ovary / Q000503:physiopathology; D013546:Sweating; D014664:Vasodilation
chemical_list: D004967:Estrogens
keywords: Hot flush; brain function; calcitonin gene related peptide; cardiovascular disease; frequency; global variation; kisseptin; memory; menopause; neuroendocrine factors; physiological changes; problem rating; vascular reactivity; vasomotor symptoms