title: Self-organized Notch dynamics generate stereotyped sensory organ patterns inDrosophila.
abstract: The emergence of spatial patterns in developing multicellular organisms relies on positional cues and cell-cell communication.Drosophilasensory organs have informed a paradigm in which these operate in two distinct steps: Prepattern factors drive localized proneural activity, then Notch-mediated lateral inhibition singles out neural precursors. Here we show that self-organization through Notch signaling also establishes the proneural stripes that resolve into rows of sensory bristles on the fly thorax. Patterning, initiated by a gradient of Delta ligand expression, progresses through inhibitory signaling between and within stripes. Thus, Notch signaling can support self-organized tissue patterning as a prepattern is transduced by cell-cell interactions into a refined arrangement of cellular fates.
authors.affiliation: Laboratoire de Physique Statistique, Ecole Normale Supérieure, CNRS, Université Pierre et Marie Curie, Université Paris Diderot, 75005 Paris, France. corson@lps.ens.fr fschweis@pasteur.fr.
authors.forename: Francis
authors.identifier: 0000-0001-7230-137X
authors.initials: F
authors.lastname: Corson
authors.affiliation: Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France.|CNRS, UMR3738, 75015 Paris, France.
authors.forename: Lydie
authors.initials: L
authors.lastname: Couturier
authors.affiliation: Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France.|CNRS, UMR3738, 75015 Paris, France.
authors.forename: Hervé
authors.identifier: 0000-0002-4997-2711
authors.initials: H
authors.lastname: Rouault
authors.affiliation: Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France.|CNRS, UMR3738, 75015 Paris, France.
authors.forename: Khalil
authors.initials: K
authors.lastname: Mazouni
authors.affiliation: Department of Developmental and Stem Cell Biology, Institut Pasteur, 75015 Paris, France. corson@lps.ens.fr fschweis@pasteur.fr.|CNRS, UMR3738, 75015 Paris, France.
authors.forename: François
authors.identifier: 0000-0001-8888-9390
authors.initials: F
authors.lastname: Schweisguth
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D002450:Cell Communication; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics / Q000378:metabolism; D008962:Models, Theoretical; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D012679:Sense Organs / Q000166:cytology / Q000196:embryology*; D015398:Signal Transduction; D013234:Stem Cells / Q000378:metabolism; D013909:Thorax / Q000294:innervation
chemical_list: D029721:Drosophila Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch