title: Vinculin in cell-cell and cell-matrix adhesions.
abstract: Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. We also highlight the recent understanding of how vinculin responds to and transmits force at integrin- and cadherin-containing adhesion complexes to the cytoskeleton. Furthermore, we discuss roles of vinculin in binding to and rearranging the actin cytoskeleton.
authors.affiliation: Department of Biochemistry, University of Iowa, Iowa City, IA, 52242, USA.
authors.forename: Jennifer L
authors.identifier: 0000-0003-0218-2680
authors.initials: JL
authors.lastname: Bays
authors.affiliation: Department of Biochemistry, University of Iowa, Iowa City, IA, 52242, USA. kris-demali@uiowa.edu.
authors.forename: Kris A
authors.initials: KA
authors.lastname: DeMali
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D022005:Adherens Junctions / Q000378:metabolism*; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion; D002465:Cell Movement; D022001:Focal Adhesions / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D008958:Models, Molecular; D060066:Protein Interaction Maps; D016596:Vinculin / Q000032:analysis / Q000378:metabolism*
chemical_list: D015820:Cadherins; D016023:Integrins; D016596:Vinculin
keywords: Cadherins; Cell adhesion; Cell migration; Force and mechanotransduction; Integrins; Vinculin