title: A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014.
abstract: This review covers the 1994-2014 literature data published for anti-CNS tumour natural products isolated from marine sponges. The focus was on highly potent antitumourics. It describes only eight promising bioactives (screened on even less number of the respective cell lines) suggesting that brain tumours actually represent quite a hot topic for the natural product research community worldwide.
authors.affiliation: a Department of Life Sciences , Institute for Multidisciplinary Research - IMSI, University of Belgrade , Belgrade , Serbia.
authors.forename: Boris
authors.initials: B
authors.lastname: Pejin
authors.affiliation: b School of Food Science and Biotechnology - SFSB, Food Oral Processing Laboratory , Zhejiang Gongshang University , Hangzhou , People's Republic of China.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Glumac
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D059001:Aquatic Organisms; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D001932:Brain Neoplasms / Q000188:drug therapy; D016543:Central Nervous System Neoplasms / Q000188:drug therapy*; D004146:Dioxanes / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D011161:Porifera / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D004146:Dioxanes; D004224:Diterpenes; D006576:Heterocyclic Compounds, 4 or More Rings; D011743:Pyrimidines; D013729:Terpenes; C581273:axistatin 1; C541047:dibromophakellin; C478200:plakortide M; C116700:sesterstatin 5
keywords: Porifera; brain tumours; natural products; new leads