title: Formulation and evaluation of transdermal drug delivery of topiramate.
abstract: BACKGROUND
  Transdermal drug delivery system (TDDS) was designed to sustain the release and improve the bioavailability of drug and patient compliance. Among the various types of transdermal patches, matrix dispersion type systems disperse the drug in the solvent along with the polymers and solvent is allowed to evaporate forming a homogeneous drug-polymer matrix. The objective of the present study was to design and formulate TDDS of topiramate (TPM) and to evaluate their extended releasein vitroandex vivo.
  
  
  METHODS
  In the present study, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising TPM with different ratios of hydrophilic and hydrophobic polymeric combinations using solvent casting technique.
  
  
  RESULTS
  The physicochemical compatibility of the drug and the polymers was studied by Fourier transform infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. The patches were further subjected to various physical evaluations along with theex vivopermeation studies using pig ear skin.
  
  
  CONCLUSIONS
  On the basis of results obtained from the physical evaluation andex vivostudies the patches containing the polymers, that is, Eudragit L 100 and polyvinylpyrrolidone, with oleic acid as the penetration enhancer were considered as the best formulations for the transdermal delivery of TPM.
authors.affiliation: Department of Pharmaceutics, Bomma Institute of Pharmacy, Khammam, Telangana, India.
authors.forename: Suneetha
authors.initials: S
authors.lastname: Cherukuri
authors.affiliation: Department of Pharmaceutical Chemistry, Bharat Institute of Technology, JNTUH, Hyderabad, India.
authors.forename: Uma Rajeswari
authors.initials: UR
authors.lastname: Batchu
authors.affiliation: Department of Pharmaceutical Chemistry, Bharat Institute of Technology, JNTUH, Hyderabad, India.
authors.forename: Kiranmai
authors.initials: K
authors.lastname: Mandava
authors.affiliation: Department of Pharmaceutics, MITS College of Pharmacy, Nalgonda, Telangana, India.
authors.forename: Vidhyullatha
authors.initials: V
authors.lastname: Cherukuri
authors.affiliation: Department of Pharmaceutical Analysis, Nalanda College of Pharmacy, Nalgonda, Telangana, India.
authors.forename: Koteswara Rao
authors.initials: KR
authors.lastname: Ganapuram
keywords: Eudragit L 100; matrix dispersion system; oleic acid; penetration enhancers; permeation studies; polyvinylpyrrolidone