title: Intrafollicular soluble RAGE benefits embryo development and predicts clinical pregnancy in infertile patients of advanced maternal age undergoing in vitro fertilization.
abstract: Soluble receptor for advanced glycation end products (sRAGE) can decoy the toxic AGEs and is considered to be a protective factor. This study aimed to evaluate the correlation between intrafollicular sRAGE levels and clinical outcomes in infertile women of young or advanced maternal age (AMA) undergoing in vitro fertilization (IVF). A total of 62 young women and 62 AMA women who would undergo IVF were included in this prospective study. The intrafollicular sRAGE concentration was measured to determine its association with the number of retrieved oocytes, fertilized oocytes, high-quality embryos or achievement of clinical pregnancy in young and AMA women, respectively. Besides, correlations between sRAGE and age or follicle-stimulating hormone (FSH) were examined. We found that the intrafollicular sRAGE levels were higher in young patients than those in AMA patients, suggesting that the sRAGE levels were inversely correlated with age. In young patients, sRAGE showed no correlation with the number of retrieved oocytes, fertilized oocytes, high-quality embryos or achievement of clinical pregnancy. But it was found that AMA patients with more retrieved oocytes, fertilized oocytes and high-quality embryos demonstrated higher sRAGE levels, which were a prognostic factor for getting clinical pregnancy independent of age or FSH level. In conclusion, the sRAGE levels decrease with age. Elevated intrafollicular sRAGE levels indicate good follicular growth, fertilization and embryonic development, and successful clinical pregnancy in AMA women, while in young women, the role of sRAGE may not be so predominant.
authors.affiliation: Reproductive Medicine Center, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Li
authors.affiliation: Reproductive Medicine Center, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Reproductive Medicine Center, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: Reproductive Medicine Center, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China.
authors.forename: Jing-Jie
authors.initials: JJ
authors.lastname: Li
authors.affiliation: Reproductive Medicine Center, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China. lxyzy@263.net.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Liang
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism*; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008423:Maternal Age; D009865:Oocytes / Q000166:cytology* / Q000378:metabolism; D011247:Pregnancy; D011446:Prospective Studies; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism*
chemical_list: C000593871:AGER protein, human; D000067759:Receptor for Advanced Glycation End Products
keywords: IVF outcomes; infertile women; soluble receptor for advanced glycation end products; women of advanced maternal age