title: Targeting the AXL signaling pathway in ovarian cancer.
abstract: In a recent publication inScience Signaling, we showed that a Mes molecular subtype of epithelial ovarian cancer (EOC) harboring epithelial-mesenchymal transition (EMT) features has a unique signaling network downstream of the GAS6/AXL pathway. Our finding leads to a potential strategy for treating the Mes subtype of EOC by targeting AXL.
authors.affiliation: Department of Obstetrics & Gynaecology, National University Hospital of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Ruby Yun-Ju
authors.initials: RY
authors.lastname: Huang
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
authors.forename: Jane
authors.initials: J
authors.lastname: Antony
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore , Singapore.
authors.forename: Tuan Zea
authors.initials: TZ
authors.lastname: Tan
authors.affiliation: Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute Singapore, National University Health System, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: David Shao-Peng
authors.initials: DS
authors.lastname: Tan
keywords: AXL; EMT; epithelial ovarian cancer