title: Novel miRNA-mRNA interactions conserved in essential cancer pathways.
abstract: Cancer is a complex disease in which unrestrained cell proliferation results in tumour development. Extensive research into the molecular mechanisms underlying tumorigenesis has led to the characterization of oncogenes and tumour suppressors that are key elements in cancer growth and progression, as well as that of other important elements like microRNAs. These genes and miRNAs appear to be constitutively deregulated in cancer. To identify signatures of miRNA-mRNA interactions potentially conserved in essential cancer pathways, we have conducted an integrative analysis of transcriptomic data, also taking into account methylation and copy number alterations. We analysed 18,605 raw transcriptome samples from The Cancer Genome Atlas covering 15 of the most common types of human tumours. From this global transcriptome study, we recovered known cancer-associated miRNA-targets and importantly, we identified new potential targets from miRNA families, also analysing the phenotypic outcomes of these genes/mRNAs in terms of survival. Further analyses could lead to novel approaches in cancer therapy.
authors.affiliation: Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville, HUVR/US/CSIC, 41013 Sevilla, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Andrés-León
authors.affiliation: REDgene Bioinformatics, Sevilla, Spain.
authors.forename: Ildefonso
authors.initials: I
authors.lastname: Cases
authors.affiliation: Program of Predictive and Personalized Medicine of Cancer (PMPPC), Germans Trias I Pujol Research Institute (IGTP), Can Ruti Campus, Badalona 08916, Barcelona, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Alonso
authors.affiliation: Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville, HUVR/US/CSIC, 41013 Sevilla, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Rojas
mesh_terms: D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015894:Genome, Human; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics*; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*; D013223:Statistics as Topic; D016019:Survival Analysis
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger