title: Poly (Ethylene Glycol)-Based Hydrogels as Self-Inflating Tissue Expanders with Tunable Mechanical and Swelling Properties.
abstract: Tissue expansion is used by plastic/reconstructive surgeons to grow additional skin/tissue for replacing or repairing lost or damaged soft tissues. Recently, hydrogels have been widely used for tissue expansion applications. Herein, a self-inflating tissue expander blend composition from three different molecular weights (2, 6, and 10 kDa) of poly (ethylene glycol) diacrylate (PEGDA) hydrogel with tunable mechanical and swelling properties is presented. The in vitro results demonstrate that, of the eight studied compositions, P6 (PEGDA 6 kDa:10 kDa (50:50)) and P8 (PEGDA 6 kDa:10 kDa (35:65)) formulations provide a balance of mechanical property and swelling capability suitable for tissue expansion. Furthermore, these expanders can be compressed up to 60% of their original height and can be loaded and unloaded cyclically at least ten times with no permanent deformation. The in vivo results indicate that these two engineered blend compositions are capable to generate a swelling pressure sufficient to dilate the surrounding tissue while retaining their original shape. The histological analyses reveal the formation of fibrous capsule at the interface between the implant and the subcutaneous tissue with no signs of inflammation. Ultimately, controlling the PEGDA chain length shows potential for the development of self-inflating tissue expanders with tunable mechanical and swelling properties.
authors.affiliation: Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Stem Cell and Regenerative Medicine Division, National Institute of Genetic Engineering and Biotechnology, Tehran, 14977-16316, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Jamadi
authors.affiliation: Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, 14977-13115, Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Shokrollahi
authors.affiliation: Stem Cell and Regenerative Medicine Division, National Institute of Genetic Engineering and Biotechnology, Tehran, 14977-16316, Iran.|Department of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, 19839-69411, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Houshmand
authors.affiliation: Animal Biotechnology Department, National Institute of Genetic Engineering and Biotechnology, Tehran, 14977-16316, Iran.
authors.forename: Mortaza Daliri
authors.initials: MD
authors.lastname: Joupari
authors.affiliation: Department of Oral and Maxillofacial Pathology, School of dentistry, Shahid Beheshti University of Medical Sciences, Tehran, 19839-69411, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mashhadiabbas
authors.affiliation: Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Physics, King Abdulaziz University, Jeddah, 21569, Saudi Arabia.|Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul, 143-701, Republic of Korea.
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
authors.affiliation: Biomaterials Innovation Research Center, Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.|Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Department of Chemical Engineering, Northeastern University, Boston, MA, 02115-5000, USA.
authors.forename: Nasim
authors.initials: N
authors.lastname: Annabi
mesh_terms: D000818:Animals; D002460:Cell Line; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry / Q000494:pharmacology; D017208:Rats, Wistar; D015625:Tissue Expansion Devices
chemical_list: D020100:Hydrogels; D011092:Polyethylene Glycols
keywords: hydrogel; mechanical properties; poly (ethylene glycol) diacrylate; swelling behavior; tissue expander