title: Tear osmolarity and ocular surface parameters in patients with psoriasis.
abstract: The aim of this study was to evaluate tear osmolarity, tear film function, and ocular surface changes in patients with psoriasis.
  At a single center, 30 eyes of 30 patients with psoriasis (group 1) and 30 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear film break-up time (TBUT) test, scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity measurement.
  Tear osmolarity values, OSDI, and Oxford scale scores were significantly higher in group 1 (309.8 ± 9.4 mOsm, 38.9 ± 1.1, and 0.7 ± 1.1, respectively) than in group 2 (292.7 ± 7.7 mOsm, 4.2 ± 0.3, and 0.1 ± 0.3, respectively; p<0.01 for all). TBUT was significantly lower in group 1 (8.7 ± 3.6 s) than in group 2 (18.1 ± 2.8 s; p<0.001). No significant differences were detected in Schirmer I test values between the groups (16.2 ± 2.5 mm in group 1 and 16.6 ± 2.3 mm in group 2; p=0.629).
  The results of this study showed that psoriasis may influence tear osmolarity and tear film function. Patients with psoriasis showed tear hyperosmolarity and tear film dysfunction.
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Goktug
authors.initials: G
authors.lastname: Demirci
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Sevil Karaman
authors.initials: SK
authors.lastname: Erdur
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Rukiye
authors.initials: R
authors.lastname: Aydin
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Balevi
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Eliacik
authors.affiliation: Department of Ophthalmology, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozsutcu
authors.affiliation: Department of Internal Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Olmuscelik
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D015352:Dry Eye Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D019793:Fluorescein; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011565:Psoriasis / Q000150:complications* / Q000503:physiopathology; D013666:Tears / Q000737:chemistry
chemical_list: D019793:Fluorescein