title: Nephrotic syndrome due to minimal change disease secondary to spider bite: clinico-pathological case of a non-described complication of latrodectism.
abstract: The patient was an 18-year-old man who developed nephrotic syndrome after a 'wheat spider' bite (Latrodectus mactans). Due to this atypical manifestation of latrodectism, a renal biopsy was performed showing minimal change disease. The nephrotic syndrome subsided after 1 week without specific treatment. This self-limited evolution suggests that the mechanism of podocyte damage was temporary and potentially mediated by a secondary mechanism of hypersensitivity or direct effect of the α-latrotoxin. The patient did not show signs of relapse in subsequent checkup. This is the first reported case of nephrotic syndrome due to a minimal change lesion secondary to latrodectism.
authors.affiliation: Department of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, RM, Chile.
authors.forename: Gonzalo P
authors.initials: GP
authors.lastname: Méndez
authors.affiliation: Nephrology Unit, Clínica Los Andes, Los Angeles, Provincia de Bío Bío, VIII Región, Chile.
authors.forename: Daniel
authors.initials: D
authors.lastname: Enos
authors.affiliation: Nephrology Unit, Clínica Los Andes, Los Angeles, Provincia de Bío Bío, VIII Región, Chile.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Moreira
authors.affiliation: Nephrology Unit, Hospital Universitario Río Hortega, Valladolid, Spain.
authors.forename: Fátima
authors.initials: F
authors.lastname: Alvaredo
authors.affiliation: Department of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, RM, Chile.
authors.forename: David
authors.initials: D
authors.lastname: Oddó
keywords: latrodectism; minimal change disease; nephrotic syndrome; proteinuria; spider bite