title: Guanosine-5'-Monophosphate Polyamine Hybrid Hydrogels: Enhanced Gel Strength Probed by z-Spectroscopy.
abstract: The self-assembling tendencies of guanosine-5'-monophosphate (GMP) can be drastically increased using polyamines, with potential applications in the production of biocompatible smart materials, as well as for the design of antitumor drugs based on G-quadruplex stabilization. Results from scanning electron microscopy (SEM), wide angle X-ray scattering (WAXS), rheology, and nuclear magnetic resonance (NMR) z-spectroscopy studies are presented.
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.|Instituto de Ciencia Molecular, Universidad de Valencia, C/ Catedrático José Beltrán n°. 2, 46980, Paterna, Spain.|School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Raquel
authors.initials: R
authors.lastname: Belda
authors.affiliation: Instituto de Ciencia Molecular, Universidad de Valencia, C/ Catedrático José Beltrán n°. 2, 46980, Paterna, Spain.
authors.forename: Enrique
authors.identifier: http://orcid.org/0000-0002-4601-6505
authors.initials: E
authors.lastname: García-España
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Gareth A
authors.identifier: http://orcid.org/0000-0002-4859-6259
authors.initials: GA
authors.lastname: Morris
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
authors.forename: Jonathan W
authors.identifier: http://orcid.org/0000-0002-7466-7794
authors.initials: JW
authors.lastname: Steed
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.|School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
authors.forename: Juan A
authors.identifier: http://orcid.org/0000-0001-9181-8892
authors.initials: JA
authors.lastname: Aguilar
keywords: G-quadruplex stabilization; GMP gels; NMR spectroscopy; polyamines; self-assembly