title: Contrast-enhanced CT features of hepatoblastoma: Can we predict histopathology?
abstract: BACKGROUND
  Hepatoblastoma is the most common hepatic malignancy occurring in the pediatric population. Intratumoral cellular behavior varies, and the small-cell undifferentiated histopathology carries a poorer prognosis than other tissue subtypes. Neoadjuvant chemotherapy is recommended for this tumor subtype prior to surgical resection in most cases. Early identification of tumors with poor prognosis could have a significant clinical impact. Objective The aim of this work was to identify imaging features of small-cell undifferentiated subtype hepatoblastoma that can help distinguish this subtype from more favorable tumors and potentially guide the clinical management. We also sought to characterize contrast-enhanced CT (CECT) features of hepatoblastoma that correlate with metastatic disease and patient outcome.
  
  
  METHODS
  Our study included 34 patients (24 males, 10 females) with a mean age of 16months (range: 0-46months) with surgically confirmed hepatoblastoma and available baseline abdominal imaging by CECT. Clinical data and CT abdominal images were retrospectively analyzed.
  
  
  RESULTS
  Five tumors with small-cell undifferentiated components were identified. All of these tumors demonstrated irregular margins on CT imaging. Advanced PRETEXT stage, vascular invasion and irregular margins were associated with metastatic disease and decreased survival. Capsular retraction was also significantly associated with decreased survival. Irregular tumor margins demonstrated statistically significant association with the presence of small-cell undifferentiated components. No other imaging feature showed statistically significant association.
  
  
  CONCLUSIONS
  Tumor margin irregularity, vascular invasion, capsular retraction, and PRETEXT stage correlate with worse patient outcomes. Irregular tumor margin was the only imaging feature significantly associated with more aggressive tumor subtype.
authors.affiliation: Department of Radiology, Seattle Children's Hospital, University of Washington, Seattle, WA, United States.
authors.forename: Akshay D
authors.initials: AD
authors.lastname: Baheti
authors.affiliation: Department of Radiology, Seattle Children's Hospital, University of Washington, Seattle, WA, United States.
authors.forename: A
authors.initials: A
authors.lastname: Luana Stanescu
authors.affiliation: Department of Industrial and System Engineering, University of Washington, Seattle, WA, United States.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Radiology, Seattle Children's Hospital, University of Washington, Seattle, WA, United States. Electronic address: teresa.chapman@seattlechildrens.org.
authors.forename: Teresa
authors.initials: T
authors.lastname: Chapman
mesh_terms: D002675:Child, Preschool; D005260:Female; D018197:Hepatoblastoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008297:Male; D020360:Neoadjuvant Therapy; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
keywords: Children; Computed tomography; Hepatoblastoma; PRETEXT; Small-cell undifferentiated