title: Copper-Catalyzed Dicarbofunctionalization of Unactivated Olefins by Tandem Cyclization/Cross-Coupling.
abstract: We present a strategy that difunctionalizes unactivated olefins in 1,2-positions with two carbon-based entities. This method utilizes alkyl/arylzinc reagents derived from olefin-tethered alkyl/aryl halides that undergo radical cyclization to generate C(sp3)-Cu complexes in situ, which are intercepted with aryl and heteroaryl iodides. A variety of (arylmethyl)carbo- and heterocycles (N, O) can be synthesized with this new method.
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico , Albuquerque, New Mexico 87131, United States.
authors.forename: Surendra
authors.initials: S
authors.lastname: Thapa
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico , Albuquerque, New Mexico 87131, United States.
authors.forename: Prakash
authors.initials: P
authors.lastname: Basnet
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico , Albuquerque, New Mexico 87131, United States.
authors.forename: Ramesh
authors.identifier: 0000-0002-8993-9131
authors.initials: R
authors.lastname: Giri