title: Antioxidant andEx VivoImmune System Regulatory Properties ofBoswellia serrataExtracts.
abstract: Boswellia serrata(BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti-inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological conditions; however the quality of the extracts needs to be standardized to increase the clinical success rate resulting from its use. In the present study, different commercially availableB. serrataextracts were employed to compare their AKBA content and in vitro antioxidant power. Furthermore, their ability to modulate the immune system regulatory properties was investigated. Our results showed that the AKBA content varied from 3.83 ± 0.10 to 0.03 ± 0.004%, with one sample in which it was not detectable. The highest antioxidant power and phenolic content were shown by the same extract, which also exhibited the highest AKBA concentration. Finally, the BS extracts showed the ability to influence the regulatory and effector T-cell compartments. Our results suggest that frankincense should be further investigated for its promising potentiality to modulate not only inflammation/oxidative stress but also immune dysregulation, but attention should be paid to the composition of the commercial extracts.
authors.affiliation: School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
authors.forename: Daniela
authors.identifier: 0000-0002-4935-7874
authors.initials: D
authors.lastname: Beghelli
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy.
authors.forename: Gloria
authors.identifier: 0000-0002-3911-8749
authors.initials: G
authors.lastname: Isani
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Roncada
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy.
authors.forename: Giulia
authors.identifier: 0000-0003-0509-1952
authors.initials: G
authors.lastname: Andreani
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Onelia
authors.identifier: 0000-0002-6996-0208
authors.initials: O
authors.lastname: Bistoni
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy.
authors.forename: Martina
authors.identifier: 0000-0002-1840-501X
authors.initials: M
authors.lastname: Bertocchi
authors.affiliation: School of Pharmacy and Health Product Sciences, University of Camerino, Camerino, Italy.
authors.forename: Giulio
authors.identifier: 0000-0001-9452-0741
authors.initials: G
authors.lastname: Lupidi
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: Alessia
authors.identifier: 0000-0003-1105-5640
authors.initials: A
authors.lastname: Alunno
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D029743:Boswellia / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts