title: Systemic Scedosporium prolificans infection in an 11-month-old Border collie with cobalamin deficiency secondary to selective cobalamin malabsorption (canine Imerslund-Gräsbeck syndrome).
abstract: An 11-month-old Border collie presented collapsed and continued to deteriorate rapidly despite supportive treatment. The dog had a history of failure to thrive and recurring respiratory infection. Laboratory abnormalities included neutrophilic leucocytosis, Heinz body anaemia, hyperammonaemia, hyperbilirubinaemia, proteinuria and hypocobalaminaemia. Post-mortem examination revealed multi-focal necrosis within the heart, kidneys, pancreas, liver, meninges and cerebral cortex. Fungal hyphae in lesions were identified as Scedosporium prolificans following culture. Subsequent genotyping confirmed that the dog carried the CUBN:c.8392delC mutation in a homozygous state, verifying hereditary cobalamin deficiency (a.k.a. Imerslund-Gräsbeck syndrome). Cobalamin deficiency may have been a predisposing factor for the development of systemic fungal infection in this dog.
authors.affiliation: Department of Pathology and Pathogen Biology, The Royal Veterinary College, Hatfield AL9 7TA, UK.
authors.forename: K
authors.initials: K
authors.lastname: Erles
authors.affiliation: Department of Clinical Science and Services, The Royal Veterinary College, Hatfield AL9 7TA, UK.
authors.forename: A
authors.initials: A
authors.lastname: Mugford
authors.affiliation: Department of Clinical Science and Services, The Royal Veterinary College, Hatfield AL9 7TA, UK.
authors.forename: D
authors.initials: D
authors.lastname: Barfield
authors.affiliation: Institute of Genetics, Vetsuisse Faculty, University of Berne, 3012 Berne, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Leeb
authors.affiliation: Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
authors.forename: P H
authors.initials: PH
authors.lastname: Kook
mesh_terms: D000749:Anemia, Megaloblastic / Q000150:complications / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000209:etiology*; D004285:Dogs; D008286:Malabsorption Syndromes / Q000150:complications / Q000662:veterinary*; D008297:Male; D009181:Mycoses / Q000209:etiology / Q000662:veterinary*; D011507:Proteinuria / Q000150:complications / Q000662:veterinary*; D021681:Scedosporium; D014805:Vitamin B 12 / Q000378:metabolism*; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000662:veterinary*
chemical_list: D014805:Vitamin B 12