title: Assessing the validity of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) scoring system in diagnosis of peripheral zone prostate cancer.
abstract: OBJECTIVE
  Assessing the accuracy of multi parametric magnetic resonance (mp-MRI) after application of PI-RADS V2 for diagnosis of prostate cancer as comparison to pathological results of trans rectal ultra-sound (TRUS) guided biopsy.
  
  
  METHODS
  138 prostatic lesions in 23 patients were retrospectively assessed and analyzed with Trans rectal ultra-sound (TRUS) guided biopsy results. Those patients underwent multi parametric magnetic resonance (mp-MRI) with application of PI-RADS V2 reporting system. The sensitivity, specificity, validity, negative predictive value and positive predictive value were calculated for PI-RADS V2 reporting system compared to biopsy-proven pathological results.
  
  
  RESULTS
  92 out of 138 lesions were positive for Peripheral zone cancer prostate. PI-RADS V2 reporting system proved 88.04% sensitive & 93.4% specific for diagnosis of prostate cancer with negative predictive value & positive predictive value of 100%.
  
  
  CONCLUSIONS
  Our results proved that mp-MRI of prostate using PI-RADS v2 scoring system had high sensitivity and specificity in diagnosis of prostate cancer and PI-RADS V2 scoring system using mp-MRI is recommended as a non-invasive diagnostic tool compared to TRUS guided biopsy.
authors.affiliation: Radiology Department, Faculty of Medicine, Ain Shams University, Egypt.
authors.forename: Eman F
authors.initials: EF
authors.lastname: Dola
authors.affiliation: Radiology Department, Faculty of Medicine, Beni Sueif University, Egypt.
authors.forename: Osama L
authors.initials: OL
authors.lastname: Nakhla
authors.affiliation: Radiology Department, Faculty of Medicine, Ain Shams University, Egypt.
authors.forename: Eman A Sh
authors.initials: EA
authors.lastname: Genidi
keywords: CG, central gland; CZ, central zone; FOV, field of view; Multi-parametric magnetic resonance images (mp-MRI); PSA, prostate- specific antigen; PZ, peripheral zone; Prostate Imaging Reporting and Data System version 2 (PI-RADS V2); Prostate cancer; TZ, transition zone; Transrectal US guided biopsy (TRUS-guided biopsy)