title: RGD-mediated delivery of small-molecule drugs.
abstract: Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to ανβ3, α5β1and ανβ6integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled to different small molecules including known cytotoxic drugs and natural products will be discussed.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
authors.forename: Sotirios
authors.initials: S
authors.lastname: Katsamakas
authors.affiliation: Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
authors.forename: Theodora
authors.initials: T
authors.lastname: Chatzisideri
authors.affiliation: Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
authors.forename: Savvas
authors.initials: S
authors.lastname: Thysiadis
authors.affiliation: Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Sarli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry*; D001688:Biological Products / Q000008:administration & dosage / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D016023:Integrins / Q000378:metabolism; D015394:Molecular Structure; D009842:Oligopeptides / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D016023:Integrins; D009842:Oligopeptides; D054852:Small Molecule Libraries; C047981:arginyl-glycyl-aspartic acid
keywords: RGD conjugates; RGD peptide; angiogenesis; integrin avβ3; targeted drug delivery; tumor therapy