title: Lack of association between platelet indices and disease stage in osteosarcoma at diagnosis.
abstract: OBJECTIVE
  The purpose of this study was to investigate the relationship between platelet indices [mean platelet volume (MPV), platelet count (PLT), platelet distribution width (PDW) and plateletcrit (PCT)] at diagnosis in osteosarcoma.
  
  
  METHODS
  The information of 233 patients with osteosarcoma at diagnosis between 2007 and 2015 was retrospectively reviewed. Clinical parameters such as gender, age, size and site of tumor, and tumor necrosis rate after neoadjuvant chemotherapy were analyzed.
  
  
  RESULTS
  No significant difference was noted in the mean values of MPV, PLT, PDW and PCT among stage I, II and III patients. In localized patients, the median disease-free survival (DFS) values were 42 and 22 months in the PLT<300×109/L and ≥300×109/L groups, respectively, but the difference was not statistically significant (P = 0.2611). No difference in the DFS among the three different levels of MPV was observed.
  
  
  CONCLUSIONS
  No significantly different platelet indices were noted among the different stages. Although a shorter median DFS was found in localized patients with PLT≥300×109/L, there was still a lack of strong evidence to demonstrate the association between platelet indices and osteosarcoma.
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Hongtao
authors.identifier: http://orcid.org/0000-0001-6532-2092
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Zimei
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Pathology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital South Campus, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Aina
authors.initials: A
authors.lastname: He
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Shen
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital South Campus, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Yuanjue
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D012516:Osteosarcoma / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D010976:Platelet Count; D055815:Young Adult