title: Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: A review.
abstract: Diets rich in fruits and vegetables may lower colorectal cancer risk. In particular, a number of in vitro and in vivo studies demonstrated that cruciferous vegetables and their active compounds elicit chemopreventive potency through multiple mechanisms. However, it is relatively unexplored whether these vegetables modulate the risk of cancer development through epigenetic mechanisms including noncoding RNAs. Therefore, the objective of the present review is to report and discuss existing evidence with regards to modulation of microRNAs (miRNAs), one variety of noncoding RNAs, by cruciferous vegetables and their chemo-preventive effects against colorectal cancers. As results, it seems clear, considering accumulating evidence regarding their interactions with cancer related genes and relevant signaling pathways, that miRNA modulation via cruciferous vegetables is an attractive target for the prevention of colorectal cancer. In addition, miRNAs have been characterized as diagnostic and prognostic biomarkers and utilized in cancer therapeutics. Thus, it is very possible that natural agents (not limited to those in cruciferous vegetables) enhance cancer therapeutic efficacy and elicit chemopreventive effects through modulating key miRNAs.
authors.affiliation: a School of Human Environmental Sciences , University of Arkansas , Fayetteville , Arkansas , USA.
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Pan
authors.affiliation: b Department of Food Science and Nutrition , University of Minnesota , St. Paul , Minnesota , USA.
authors.forename: Breann
authors.initials: B
authors.lastname: Abernathy
authors.affiliation: c Department of Food and Biotechnology , Korea University , Sejong , Republic of Korea.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: c Department of Food and Biotechnology , Korea University , Sejong , Republic of Korea.
authors.forename: Jin Hyup
authors.initials: JH
authors.lastname: Lee
authors.affiliation: c Department of Food and Biotechnology , Korea University , Sejong , Republic of Korea.
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: d Department of Food Science , Gyeongnam National University of Science and Technology , Jinju , Republic of Korea.
authors.forename: Eui Cheol
authors.initials: EC
authors.lastname: Shin
authors.affiliation: a School of Human Environmental Sciences , University of Arkansas , Fayetteville , Arkansas , USA.
authors.forename: Jae Kyeom
authors.initials: JK
authors.lastname: Kim
mesh_terms: D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D019607:Brassicaceae; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D004032:Diet; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D016588:Anticarcinogenic Agents; D035683:MicroRNAs
keywords: Glucosinolates; colorectal cancer; cruciferous vegetables; microRNA