title: Quality of life of liver donors following donor hepatectomy.
abstract: BACKGROUND
  Although morbidity following living liver donation is well characterized, there is sparse data regarding health-related quality of life (HRQOL) of donors.
  
  
  METHODS
  HRQOL of 200 consecutive live liver donors from 2011-2014 performed at an Indian center were prospectively collected using the SF-36 version 2, 1 year after surgery. The effect of donor demographics, operative details, post-operative complications (Clavien-Dindo and 50-50 criteria), and recipient mortality on the quality-of-life (QOL) scoring was analyzed.
  
  
  RESULTS
  Among 200 donors (female/male=141:59), 77 (38.5%) had complications (14.5%, 16.5%, 4.5%, and 3.5%, Clavien-Dindo grades I-IV, respectively). The physical composite score (PCS) of donors 1 year after surgery was less than ideal (48.75±9.5) while the mental composite score (MCS) was good (53.37±6.16). Recipient death was the only factor that showed a statistically significant correlation with both PCS (p<0.001) and MCS (p=0.05). Age above 50 years (p<0.001), increasing body mass index (BMI) (p=0.026), and hospital stay more than 14 days ( p= 0.042) negatively affected the physical scores while emergency surgery (p<0.001) resulted in lower mental scores. Gender, postoperative complications, type of graft, or fulfillment of 50-50 criteria did not influence HRQOL. On asking the hypothetical question whether the donors would be willing to donate again, 99% reiterated there will be no change in their decision.
  
  
  CONCLUSIONS
  Recipient death, donation in emergency setting, age above 50, higher BMI, and prolonged hospital stay are factors that lead to impaired HRQOL following live liver donation. Despite this, 99% donors did not repent the decision to donate.
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Biju
authors.initials: B
authors.lastname: Chandran
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Viju Kumar
authors.initials: VK
authors.lastname: Bharathan
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India. johnssm20981@aims.amrita.edu.
authors.forename: Johns
authors.identifier: http://orcid.org/0000-0003-1590-999X
authors.initials: J
authors.lastname: Shaji Mathew
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Binoj Sivasankara Pillai Thankamony
authors.initials: BSPT
authors.lastname: Amma
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Unnikrishnan
authors.initials: U
authors.lastname: Gopalakrishnan
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Balakrishnan
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Ramachandran Narayana
authors.initials: RN
authors.lastname: Menon
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Puneet
authors.initials: P
authors.lastname: Dhar
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Sudheer Othiyil
authors.initials: SO
authors.lastname: Vayoth
authors.affiliation: Department of Gastrointestinal Surgery and Solid Organ Transplant, Amrita Institute of Medical Sciences and Research Centre, Amrita University, Kochi, 682 041, India.
authors.forename: Sudhindran
authors.initials: S
authors.lastname: Surendran
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D002648:Child; D015331:Cohort Studies; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007902:Length of Stay; D016031:Liver Transplantation / Q000401:mortality; D019520:Living Donors / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D013997:Time Factors; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Liver donor; Living donor liver transplantation; Quality of life; SF-36