title: Separation of Solid Stress From Interstitial Fluid Pressure in Pancreas Cancer Correlates With Collagen Area Fraction.
abstract: Elevated total tissue pressure (TTP) in pancreatic adenocarcinoma is often associated with stress applied by cellular proliferation and hydrated hyaluronic acid osmotic swelling; however, the causal roles of collagen in total tissue pressure have yet to be clearly measured. This study illustrates one direct correlation between total tissue pressure and increased deposition of collagen within the tissue matrix. This observation comes from a new modification to a conventional piezoelectric pressure catheter, used to independently separate and quantify total tissue pressure, solid stress (SS), and interstitial fluid pressure (IFP) within the same tumor location, thereby clarifying the relationship between these parameters. Additionally, total tissue pressure shows a direct correlation with verteporfin uptake, demonstrating the impediment of systemically delivered molecules with increased tissue hypertension.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Nieskoski
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755.
authors.forename: Kayla
authors.initials: K
authors.lastname: Marra
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Gunn
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Kanick
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755;Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY 14627.
authors.forename: Marvin M
authors.initials: MM
authors.lastname: Doyley
authors.affiliation: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
authors.forename: Tayyaba
authors.initials: T
authors.lastname: Hasan
authors.affiliation: Institute for Liver and Digestive Health, University College London, London NW3 2QG, UK.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Pereira
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755.
authors.forename: B
authors.initials: B
authors.lastname: Stuart Trembly
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 e-mail: Brian.W.Pogue@Dartmouth.edu.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Pogue
mesh_terms: D000818:Animals; D001692:Biological Transport; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic; D003094:Collagen / Q000378:metabolism*; D019245:Compressive Strength; D045604:Extracellular Fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D011166:Porphyrins / Q000378:metabolism; D011312:Pressure; D051381:Rats; D013314:Stress, Mechanical; D000077362:Verteporfin
chemical_list: D011166:Porphyrins; D000077362:Verteporfin; D003094:Collagen