title: Surgical resection of pulmonary metastases from colorectal cancer: 11 years of experiences.
abstract: OBJECTIVE
  To analyze the benefits and prognostic factors after surgical resection of pulmonary metastases from colorectal cancer (CRC).
  
  
  METHODS
  From Jan. 2004 to Jan. 2015, continuous 88 cases diagnosed with pulmonary metastases from CRC, including 15 cases of synchronous metastases and 73 metachronous metastases, were analyzed in the retrospective study.
  
  
  RESULTS
  All of these 88 cases underwent curative pulmonary resection including 8 cases of simultaneous surgery. The one-year, three-year and five-year survival of the 88 cases were 93.4%, 60.2% and 35.7%, respectively. 63 patients just have one metastasis, and 25 patients have more than one metastasis. Additionally, the one-year, three-year and five-year survival was 98.1%, 70.2% and 40.3% respectively in one metastasis group, while 80.1%, 37.9% and 22.5% respectively in more than one metastasis group (p = 0.003). DFS of 37 metachronous metastases were equal or greater than 18 months, and DFS of 36 metachronous metastases were less than 18 months. The one-year, three-year and five-year survival was 97.8%, 77.9% and 41.4% respectively in the DFS≥18 month group, while 88.2%, 44.6% and 28.1% respectively in the DFS<18 month group (p = 0.01).
  
  
  CONCLUSIONS
  Surgical resection of pulmonary metastases from colorectal cancer can improve survival rate in selected patients. It seems that the number of metastases is an independence prognostic factor in surgical treatment. Furthermore, longer DFI implies longer survival for resectable CRC pulmonary metastases.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Guoquan
authors.initials: G
authors.lastname: Cao
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Dezhi
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Department of surgical oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Lechi
authors.initials: L
authors.lastname: Ye
authors.affiliation: Department of surgical oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of surgical oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of surgical oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Shixu
authors.identifier: http://orcid.org/0000-0002-3920-0697
authors.initials: S
authors.lastname: Lyu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis