title: Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population.
abstract: OBJECTIVE
  IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN.
  
  
  METHODS
  Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI).
  
  
  RESULTS
  No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes.
  
  
  CONCLUSIONS
  IFN-γ polymorphisms may be involved in the development and progression of IgAN.
authors.affiliation: Department of Nephrology, Xi'an, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Nephrology, Xi'an, China.
authors.forename: Linting
authors.initials: L
authors.lastname: Wei
authors.affiliation: Department of Oncology, Second Affiliated Hospital, Xi'an, China.
authors.forename: Xinghan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Nephrology, Xi'an, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Nephrology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Niu
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Nephrology, Xi'an, China.
authors.forename: Ganglian
authors.initials: G
authors.lastname: Yao
authors.affiliation: Department of Oncology, Second Affiliated Hospital, Xi'an, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Pathology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Nephrology, Xi'an, China.
authors.forename: Rongguo
authors.initials: R
authors.lastname: Fu
mesh_terms: D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006801:Humans; D007371:Interferon-gamma / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D007371:Interferon-gamma
keywords: Case-control study; IFN-γ; IgA nephropathy; Risk