title: Linear and Angular Heteroacenes from Double-Electrophilic Cyclization (DEC) and DEC-Reductive Elimination of Diynes.
abstract: Linear and angular heteroacenes are prepared from terminal alkynes bearing tethered nucleophiles in two steps. Linear heteroacenes are formed from the homocoupling of these alkynes followed by reaction with a double electrophile (ECl2) to induce a tricyclization reaction cascade involving double-electrophilic cyclization (DEC). Related angular heteroacenes are formed from the prior substitution of the chloro groups in ECl2with the same terminal alkyne followed by reaction with AuCl3to produce a DEC-reductive-elimination (DECRE) reaction.
authors.affiliation: Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville Victoria 3052, Australia.
authors.forename: Akhil
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville Victoria 3052, Australia.
authors.forename: Bernard L
authors.identifier: 0000-0003-4410-2423
authors.initials: BL
authors.lastname: Flynn