title: Glutathione alleviated peripheral neuropathy in oxaliplatin-treated mice by removing aluminum from dorsal root ganglia.
abstract: Oxaliplatin, a platinum-based anti-cancer drug, induces peripheral neuropathy as a side effect and causes cold hyperalgesia in cancer patients receiving anti-cancer chemotherapy. In oxaliplatin-treated mice, aluminum was accumulated in the dorsal root ganglia (DRG), and accumulated aluminum in DRG or other organs aggravated oxaliplatin-induced neuropathic pain. To investigate whether aluminum oxalate, which is the compound of aluminum and oxaliplatin, might be the peripheral neuropathy inducer, the withdrawal responses of mice to coldness, the expression of transient receptor potential ankyrin 1 and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays in DRG were analyzed in mice administered with aluminum oxalate. In addition, the concentrations of aluminum in aluminum oxalate-treated mice were significantly increased compared to those of mice treated with aluminum chloride. To alleviate neuropathic pain, glutathione (GSH), known as an antioxidant and a metal chelator, was injected into oxaliplatin-treated mice. The concentrations of aluminum in the DRG were decreased by the chelation action of GSH. Taken together, behavioral and molecular analyses also supported that aluminum accumulation on the DRG might be a factor for neuropathic pain. This result also suggested that the aluminum chelation by GSH can provide an alleviatory remedy of neuropathic pain for cancer patients with oxaliplatin-induced neuropathic pain.
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University Suwon 16419, Korea.
authors.forename: Minji
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University Suwon 16419, Korea.
authors.forename: Sungrae
authors.initials: S
authors.lastname: Cho
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University Suwon 16419, Korea.
authors.forename: Kangsan
authors.initials: K
authors.lastname: Roh
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University Suwon 16419, Korea.
authors.forename: Jisook
authors.initials: J
authors.lastname: Chae
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University Suwon 16419, Korea.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University Suwon 16419, Korea.
authors.forename: Jaehyun
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, St. Mary's Hospital, Catholic University of Korea Seoul 06591, Korea.
authors.forename: Myung-Ah
authors.initials: MA
authors.lastname: Lee
authors.affiliation: Department of Chemistry and Nano Science, EwhaWomans University Seoul 03760, Korea.
authors.forename: Jinheung
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Biological Science, Mokpo National University Muan 58554 Korea.
authors.forename: Chung-Kyoon
authors.initials: CK
authors.lastname: Auh
authors.affiliation: Department of Family Medicine, Yeomchanghwan Hospital Seoul 06605, Korea.
authors.forename: Chang-Hwan
authors.initials: CH
authors.lastname: Yeom
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University Suwon 16419, Korea.
authors.forename: Sukchan
authors.initials: S
authors.lastname: Lee
keywords: Aluminum; TRPA1; glutathione; oxaliplatin; peripheral neuropathy