title: Hyperbaric oxygen therapy modulates serum OPG/RANKL in femoral head necrosis patients.
abstract: Hyperbaric oxygen therapy (HBOT) has beneficial effects on avascular necrosis of femoral head (ANFH), but its mechanism of action is still unclear. We investigated if HBOT upregulates serum osteoprotegerin (OPG) and/or inhibits osteoclast activation. 23 patients with unilateral ANFH at stage I, II and III consented to the study: the patients received standard HBOT. Serum OPG levels were obtained at the beginning of HBOT (T0), after 15 sessions (T1), 30 sessions (T2), after a 30-day break (T3), and after 60 sessions (T4). Magnetic resonance imaging (MRI) was obtained at T0 and about one year from the end of HBO treatments. Lesion size was compared between pre- and post-HBOT. 19 patients completed the study. HBOT reduced pain symptoms in all patients. HBOT significantly reduced lesion size in all stage I and II patients and in 2 of 11 stage III patients. HBOT increased serum OPG levels but receptor activator of nuclear factor kappa-B ligand (RANKL) levels did not change.
authors.affiliation: a Department of Biomedical Sciences, Physiological Laboratory , University of Padova , Padova , Italy.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Vezzani
authors.affiliation: a Department of Biomedical Sciences, Physiological Laboratory , University of Padova , Padova , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Quartesan
authors.affiliation: a Department of Biomedical Sciences, Physiological Laboratory , University of Padova , Padova , Italy.
authors.forename: Pasqua
authors.initials: P
authors.lastname: Cancellara
authors.affiliation: b Anesthesia , Tampa General Hospital; TEAM Health Anesthesia Research Institute , Tampa , FL , USA.
authors.forename: Enrico
authors.initials: E
authors.lastname: Camporesi
authors.affiliation: b Anesthesia , Tampa General Hospital; TEAM Health Anesthesia Research Institute , Tampa , FL , USA.
authors.forename: Devanand
authors.initials: D
authors.lastname: Mangar
authors.affiliation: c Florida Orthopedic Institute , Tampa , FL , USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bernasek
authors.affiliation: b Anesthesia , Tampa General Hospital; TEAM Health Anesthesia Research Institute , Tampa , FL , USA.
authors.forename: Prachiti
authors.initials: P
authors.lastname: Dalvi
authors.affiliation: d The Institute for Human Performance , SUNY Upstate Medical University , Syracuse , NY , USA.
authors.forename: Zhongjin
authors.initials: Z
authors.lastname: Yang
authors.affiliation: a Department of Biomedical Sciences, Physiological Laboratory , University of Padova , Padova , Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Paoli
authors.affiliation: a Department of Biomedical Sciences, Physiological Laboratory , University of Padova , Padova , Italy.
authors.forename: Alex
authors.initials: A
authors.lastname: Rizzato
authors.affiliation: a Department of Biomedical Sciences, Physiological Laboratory , University of Padova , Padova , Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Bosco
mesh_terms: D005260:Female; D005271:Femur Head Necrosis / Q000097:blood* / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D053244:Osteoprotegerin / Q000097:blood* / Q000378:metabolism; D053245:RANK Ligand / Q000097:blood*
chemical_list: D053244:Osteoprotegerin; D053245:RANK Ligand; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human
keywords: Avascular necrosis of femoral head; bone remodeling; hyperbaric oxygen therapy; serum osteoprotegerin; serum receptor activator of NF-kB Ligand