title: metabolic profiling of Parkinson's disease and mild cognitive impairment.
abstract: Early diagnosis of Parkinson's disease and mild cognitive impairment is important to enable prompt treatment and improve patient welfare, yet no standard diagnostic test is available. Metabolomics is a powerful tool used to elucidate disease mechanisms and identify potential biomarkers.
  
  
  
  The objective of this study was to use metabolic profiling to understand the pathoetiology of Parkinson's disease and to identify potential disease biomarkers.
  
  
  
  This study compared the serological metabolomic profiles of early-stage Parkinson's patients (diagnosed < 12 months) to asymptomatic matched controls using an established array based detection system (DiscoveryHD4™, Metabolon, UK), correlating metabolite levels to clinical measurements of cognitive impairment.
  
  
  
  A total of 1434 serological metabolites were assessed in early-stage Parkinson's disease cases (n = 41) and asymptomatic matched controls (n = 40). Post-quality control, statistical analysis identified n = 20 metabolites, predominantly metabolites of the fatty acid oxidation pathway, associated with Parkinson's disease and mild cognitive impairment. Receiver operator curve assessment confirmed that the nine fatty acid oxidation metabolites had good predictive accuracy (area under curve = 0.857) for early-stage Parkinson's disease and mild cognitive impairment (area under curve = 0.759).
  
  
  
  Our study indicates that fatty acid oxidation may be an important component in the pathophysiology of Parkinson's disease and may have potential as a diagnostic biomarker for disease onset and mild cognitive impairment. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
authors.affiliation: Mitochondrial Research Group, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: Florence
authors.initials: F
authors.lastname: Burté
authors.affiliation: Institute for Cell and Molecular Bioscience, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: David
authors.initials: D
authors.lastname: Houghton
authors.affiliation: Mitochondrial Research Group, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: Hannah
authors.initials: H
authors.lastname: Lowes
authors.affiliation: Mitochondrial Research Group, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: Angela
authors.initials: A
authors.lastname: Pyle
authors.affiliation: Mitochondrial Research Group, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Nesbitt
authors.affiliation: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: Alison
authors.initials: A
authors.lastname: Yarnall
authors.affiliation: Mitochondrial Research Group, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: Patrick
authors.initials: P
authors.lastname: Yu-Wai-Man
authors.affiliation: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Burn
authors.affiliation: Mitochondrial Research Group, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: Mauro
authors.initials: M
authors.lastname: Santibanez-Koref
authors.affiliation: Mitochondrial Research Group, Newcastle University, Newcastle Upon Tyne, UK.
authors.forename: Gavin
authors.initials: G
authors.lastname: Hudson
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001769:Blood / Q000378:metabolism*; D060825:Cognitive Dysfunction / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: Parkinson's Disease; fatty acid beta oxidation; metabolomics