title: Geriatric patients are predisposed to strabismus following thyroid-related orbital decompression surgery: A multivariate analysis.
abstract: Geriatric patients (age ≥ 65) are prone to complications after surgery and are at risk for severe thyroid eye disease (TED). In this study, we aim to identify preoperative demographic and TED patterns associated with geriatric patients who underwent decompression surgery, to examine the effect of age on postoperative strabismus rates, and to identify factors that may contribute to postoperative strabismus in the geriatric subgroup. We retrospectively reviewed patients who underwent thyroid-related orbital decompression surgery at the Kellogg Eye Center, University of Michigan, between 1999 and 2014. Primary outcome was postoperative strabismus requiring palliation with prisms and/or strabismus surgery. Descriptive, univariate, and multivariable logistic regression analyses were used to define association of geriatric age with postoperative strabismus and determine predictors of postoperative strabismus. Of 241 patients, 41 (17.0%) were geriatric. They were less likely to undergo bilateral decompression (P = 0.012), less likely to be current smokers at time of decompression (P = 0.002), and more likely to have preoperative primary gaze diplopia (P = 0.001). Postoperative strabismus rates for geriatric patients (≥ 65 years of age), ages 50-65, 30-50, and < 30, were 73.2%, 41.3%, 31.9%, and 15.8%, respectively (P = 0.002). On multivariable analysis, geriatric age remained an independent risk factor for postoperative strabismus when compared to each age group (P ≤ 0.001). Among geriatric patients in subgroup multivariable analysis, balanced as opposed to lateral wall decompression (P = 0.038) and shorter TED duration (P = 0.031) were independently predictive of postoperative strabismus.
authors.affiliation: a Department of Ophthalmology and Visual Sciences , W. K. Kellogg Eye Center, University of Michigan , Ann Arbor , Michigan , USA.
authors.forename: Chris Y
authors.initials: CY
authors.lastname: Wu
authors.affiliation: a Department of Ophthalmology and Visual Sciences , W. K. Kellogg Eye Center, University of Michigan , Ann Arbor , Michigan , USA.
authors.forename: Alon
authors.initials: A
authors.lastname: Kahana
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D019299:Decompression, Surgical / Q000009:adverse effects*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000209:etiology*; D005853:Geriatrics; D049970:Graves Ophthalmopathy / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009915:Orbit / Q000601:surgery*; D011183:Postoperative Complications; D012189:Retrospective Studies; D012307:Risk Factors; D013285:Strabismus / Q000209:etiology* / Q000503:physiopathology
keywords: Decompression; Graves’ disease; geriatric; strabismus; thyroid eye disease