title: Delayed Recurrence of Herpes Simplex Virus Infection in the Central Nervous System After Neonatal Infection and Completion of Six Months of Suppressive Therapy.
abstract: A 10-day-old child was treated for neonatal herpes simplex virus (HSV) central nervous system (CNS) disease with 21 days of intravenous acyclovir and 6 months of oral acyclovir. She presented 7 years later with HSV CNS disease and new lesions in her brain, illustrating the non-benign nature of delayed recurrent HSV CNS disease.
authors.affiliation: Departments of Family Medicine.
authors.forename: Baylee
authors.initials: B
authors.lastname: Henderson
authors.affiliation: Department of Pediatrics, University of Alabama at Birmingham.
authors.forename: David W
authors.initials: DW
authors.lastname: Kimberlin
authors.affiliation: Pediatrics, University of Alberta, Edmonton, Canada.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Forgie
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology / Q000821:virology; D002648:Child; D020803:Encephalitis, Herpes Simplex / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000821:virology; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging; D012008:Recurrence; D018139:Simplexvirus
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir
keywords: antiviral therapy; herpes simplex virus; mother-to-child transmission; neonatal herpes; recurrence