title: Thermogenesis by THADA.
abstract: THADA has been associated with cold adaptation and diabetes in humans, but the cellular and molecular basis of its function has been unknown. Moraru and colleagues (2017) report in this issue of Developmental Cell that it triggers thermogenesis by uncoupling ATP hydrolysis from calcium transport into the endoplasmic reticulum.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA 02115. Electronic address: nirmalya_chatterjee@hms.harvard.edu.
authors.forename: Nirmalya
authors.initials: N
authors.lastname: Chatterjee
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Boston, MA 02115. Electronic address: perrimon@genetics.med.harvard.edu.
authors.forename: Norbert
authors.initials: N
authors.lastname: Perrimon
mesh_terms: D000818:Animals; D003080:Cold Temperature; D004721:Endoplasmic Reticulum; D006801:Humans; D007473:Ion Channels; D024101:Mitochondrial Proteins; D022722:Thermogenesis
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins