title: Involvement of 17β-hydroxysteroid dehydrogenase type gene 1 937 A>G polymorphism in infertility in Polish Caucasian women with endometriosis.
abstract: OBJECTIVE
  Endometriosis is considered to be an estrogen-related chronic inflammatory disease. The 17β-hydroxysteroid dehydrogenase 1 (HSD17B1) converts estrone to 17β estradiol. The role of HSD17B1 937 A>G (rs605059) single nucleotide polymorphism (SNP) in development of endometriosis is still disputable. This study evaluated the association of the HSD17B1 937 A>G (rs605059) SNP with infertile women affected by endometriosis from Polish Caucasian population.
  
  
  METHODS
  The genotyping of cases (n = 290) and fertile women (n = 410) was conducted by high-resolution melting curve analysis.
  
  
  RESULTS
  Statistical analysis demonstrated that the HSD17B1 937 A>G SNP is associated with endometriosis in stages I and II. The ptrendand pallelicvalues calculated for the HSD17B1 937 A>G polymorphism were statistically significant and were equal to 0.001 and 0.0009, respectively. There was a significant association for the dominant model: (AG + GG vs AA) OR = 1.973 (95% CI = 1.178-3.304), p = 0.009, and for the recessive model: (GG vs AG + AA) OR = 1.806 (95% CI = 1.178-2.770), p = 0.006. However, we did not find statistical association of HSD17B1 937 A>G polymorphism with all infertile women with endometriosis or infertile women with endometriosis in stages III and IV.
  
  
  CONCLUSIONS
  Our genetic study demonstrated HSD17B1 937 G variant as a risk factor for infertility in women with stage I and II endometriosis in Polish Caucasian patients.
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Osiński
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mostowska
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland.
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Wirstlein
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland.
authors.forename: Jana
authors.initials: J
authors.lastname: Skrzypczak
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Paweł Piotr
authors.initials: PP
authors.lastname: Jagodziński
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, 33 Polna St, 60-535, Poznań, Poland. mal.gin@poczta.fm.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szczepańska
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000235:genetics* / Q000503:physiopathology; D004960:Estradiol Dehydrogenases / Q000235:genetics*; D004967:Estrogens / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007247:Infertility, Female / Q000235:genetics* / Q000503:physiopathology; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D004967:Estrogens; D004960:Estradiol Dehydrogenases; C513331:HSD17B1 protein, human
keywords: Endometriosis; HSD17B1; Polymorphism