title: ent-Abietane and Tigliane Diterpenoids from the Roots of Euphorbia fischeriana and Their Inhibitory Effects against Mycobacterium smegmatis.
abstract: An investigation on the bioactive chemical constituents of the roots of Euphorbia fischeriana has been conducted, with 21 diterpenoids obtained using various chromatographic techniques. On the basis of spectroscopic data analysis, the new compounds were elucidated as four ent-abietane-type diterpenoids (1-4) and four tigliane-type diterpenoids (13-16). Also obtained were eight known ent-abietane (5-12) and five known tigliane (17-21) diterpenoids. The potential antituberculosis effects of these diterpenoids were evaluated using a Mycobacterium smegmatis model. The most potent compound according to the in vitro bioassay used was 17-hydroxyjolkinolide B (12) (MIC 1.5 μg/mL).
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Chun-Jie
authors.initials: CJ
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Qiu-Long
authors.initials: QL
authors.lastname: Yan
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Ma
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Cheng-Peng
authors.initials: CP
authors.lastname: Sun
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Xiang-Ge
authors.initials: XG
authors.lastname: Tian
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Xiu-Yan
authors.initials: XY
authors.lastname: Han
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Sa
authors.initials: S
authors.lastname: Deng
authors.affiliation: College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University , Dalian 116044, People's Republic of China.
authors.forename: Xiao-Chi
authors.identifier: 0000-0003-4397-537X
authors.initials: XC
authors.lastname: Ma
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000737:chemistry / Q000187:drug effects*; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C057916:17-hydroxyjolkinolide B