title: Examining the validity of the rheumatoid arthritis magnetic resonance imaging score according to the OMERACT filter-a systematic literature review.
abstract: To examine whether the RA MRI score (RAMRIS) for RA of the wrist/hand meets the OMERACT filter criteria-truth (validity), discrimination and feasibility.
  
  
  
  We conducted a systematic literature review in PubMed and Scopus, from 1970 through June 2014, focused on MRI measures of synovitis, osteitis/bone marrow oedema, erosions and/or joint space narrowing in RA randomized controlled trials and observational studies with cohort size ⩾10. Strength of evidence was assessed using the Cochrane Handbook criteria.
  
  
  
  Of 634 MRI titles/abstracts, 202 met the review criteria, with 92 providing at least 1 type of validity. Four articles provided criterion validity, and 26 articles utilized RAMRIS to assess 1.5 T MRI images. Histopathology data showed inflammation corresponding to MRI of synovitis and osteitis. MRI erosions corresponded to those identified with CT. Content and construct validity for RAMRIS synovitis, osteitis and erosions were documented by correlations with clinical, laboratory and/or radiographic data. Each measure was sensitive to change and responsive to therapy. RAMRIS synovitis and osteitis were able to discriminate between the efficacy of treatments vs placebo in 12-week studies, whereas RAMRIS erosions required studies of ⩾24 weeks.
  
  
  
  RAMRIS synovitis, osteitis and erosions imaged with 1.5 T MRI are valid and useful for evaluating joint inflammation and damage for RA of the wrist/hand, according to the OMERACT filter.
authors.affiliation: Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles.
authors.forename: Thasia G
authors.initials: TG
authors.lastname: Woodworth
authors.affiliation: Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles.
authors.forename: Olga
authors.initials: O
authors.lastname: Morgacheva
authors.affiliation: Keck School of Medicine, University of Southern California, Santa Monica, CA, USA.
authors.forename: Olga L
authors.initials: OL
authors.lastname: Pimienta
authors.affiliation: Keck School of Medicine, University of Southern California, Santa Monica, CA, USA.
authors.forename: Orrin M
authors.initials: OM
authors.lastname: Troum
authors.affiliation: Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles.
authors.forename: Veena K
authors.initials: VK
authors.lastname: Ranganath
authors.affiliation: Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, UCLA, Los Angeles.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Furst
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents
keywords: MRI; OMERACT filter; RAMRIS; clinical trials; magnetic resonance imaging; rheumatoid arthritis; rheumatoid arthritis magnetic resonance imaging score; structural progression