title: Ophthalmic involvement in nasopharyngeal carcinoma.
abstract: This article desribes the ophthalmic involvement in patients with nasopharyngeal carcinoma (NPC) pre- and post-treatment. We retrospectively reviewed data for 354 consecutive patients diagnosed with or treated for NPC at a single tertiary centre between April 2007 and July 2015. We identified 27 (7.6%) patients with ophthalmic involvement due to NPC or its treatment. Symptomatic orbital invasion by tumor occurred in 13 of 27 patients (48.1%). The mean age of diagnosis in these patients was 54 years, and 8 (61.5%) had no prior diagnosis of NPC. Ocular signs, but no orbital invasion, was present in 8 patients (29.6%). Incidental orbital involvement was detected on imaging in 2 patients (7.4%). Radiotherapy-related ocular complications affected 4 patients (14.8%). Ophthalmic symptoms from orbital invasion can be the initial presentation of NPC. This disease tends to affect a younger group of patients and early recognition is important to minimize morbidity and mortality.
authors.affiliation: a Department of Ophthalmology , National University Health System , Singapore , Singapore.
authors.forename: Wendy Meihua
authors.initials: WM
authors.lastname: Wong
authors.affiliation: a Department of Ophthalmology , National University Health System , Singapore , Singapore.
authors.forename: Stephanie Ming
authors.initials: SM
authors.lastname: Young
authors.affiliation: a Department of Ophthalmology , National University Health System , Singapore , Singapore.
authors.forename: Shantha
authors.initials: S
authors.lastname: Amrith
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy; D005134:Eye Neoplasms / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000532:radiotherapy; D009361:Neoplasm Invasiveness; D009918:Orbital Neoplasms / Q000453:epidemiology / Q000473:pathology*; D011832:Radiation Injuries / Q000453:epidemiology / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D014786:Vision Disorders / Q000175:diagnosis
keywords: Cancer epidemiology; cranial nerve palsy; nasopharyngeal carcinoma; orbit; radiotherapy