title: Magnesium sulfate for neuroprotection in the setting of chorioamnionitis.
abstract: OBJECTIVE
  We examined the effects of magnesium on premature neonatal outcomes complicated by chorioamnionitis.
  
  
  METHODS
  We conducted a secondary analysis of data from the BEAM Trial, an RCT to determine if antenatal magnesium decreases the incidence of CP in preterm birth. We compared the effect of magnesium sulfate by the presence or absence of chorioamnionitis. Outcomes examined include CP, IVH, NEC, BPD, and assessments of mental and motor disability. Logistic regression was used to estimate adjusted odds ratios of each outcome.
  
  
  RESULTS
  About 1944 women were included in this analysis of which 228 were diagnosed with chorioamnionitis. Demographic characteristics were similar between women randomized to receive magnesium or placebo. Magnesium therapy demonstrated no significant reduction in CP in the presence of chorioamnionitis (OR 0.76, CI: 0.19-2.76) but does demonstrate benefit in the absence of chorioamnionitis (OR 0.52, CI: 0.31-0.86).
  
  
  CONCLUSIONS
  Antenatal magnesium did not show a clear neuroprotective effect in the setting of chorioamnionitis.
authors.affiliation: a Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Duke University Medical Center , Durham , NC , USA.
authors.forename: James M
authors.identifier: http://orcid.org/0000-0003-2444-5701
authors.initials: JM
authors.lastname: Edwards
authors.affiliation: b Division of Neonatal-Perinatal Medicine, Department of Pediatrics , Duke University Medical Center , Durham , NC , USA.
authors.forename: Laura E
authors.identifier: http://orcid.org/0000-0003-1512-6143
authors.initials: LE
authors.lastname: Edwards
authors.affiliation: a Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Duke University Medical Center , Durham , NC , USA.
authors.forename: Geeta K
authors.identifier: http://orcid.org/0000-0001-5092-6993
authors.initials: GK
authors.lastname: Swamy
authors.affiliation: a Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Duke University Medical Center , Durham , NC , USA.
authors.forename: Chad A
authors.initials: CA
authors.lastname: Grotegut
mesh_terms: D000328:Adult; D002547:Cerebral Palsy / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D002821:Chorioamnionitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth; D011295:Prenatal Care
chemical_list: D018696:Neuroprotective Agents; D008278:Magnesium Sulfate
keywords: Chorioamnionitis; cerebral palsy; magnesium sulfate; neuroprotection; pregnancy; preterm birth