title: Reduced brain activity in female patients with non-alcoholic fatty liver disease as measured by near-infrared spectroscopy.
abstract: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired health-related quality of life including physical and mental state. Near-infrared spectroscopy (NIRS) is a useful tool for evaluation of brain activity and depressive state. This study aimed to determine the brain activity of female NAFLD patients using NIRS. Cerebral oxygenated hemoglobin (oxy-Hb) concentration during a verbal fluency task (VFT) was measured using NIRS in 24 female NAFLD patients and 15 female healthy controls. The Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire was administered to both groups before NIRS. There was no significant difference in CES-D score between groups. However, the oxy-Hb concentration and number of words during the VFT were less in NAFLD compared to healthy controls. The mean value of oxy-Hb concentration during 0-60 s VFT in the frontal lobe was also smaller in NAFLD patients compared to healthy controls (0.082 ± 0.126 vs. 0.183 ± 0.145, P < 0.001). Cerebral oxygen concentration is poorly reactive in response to VFT in female NAFLD patients. This may indicate an association between decreased brain activity and NAFLD regardless of depression.
authors.affiliation: Departments of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Atsushi
authors.identifier: http://orcid.org/0000-0003-0568-8361
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Kono
authors.affiliation: Department of Neuropsychiatry, The University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Wada
authors.affiliation: Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Sachie
authors.initials: S
authors.lastname: Oshima
authors.affiliation: Departments of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Abe
authors.affiliation: Departments of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Imaizumi
authors.affiliation: Departments of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Fujita
authors.affiliation: Departments of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: Departments of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Okai
authors.affiliation: Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Miura
authors.affiliation: Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Hirooki
authors.initials: H
authors.lastname: Yabe
authors.affiliation: Departments of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D016022:Case-Control Studies; D003863:Depression / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D059907:Functional Neuroimaging; D006801:Humans; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000523:psychology; D010108:Oxyhemoglobins / Q000378:metabolism; D011788:Quality of Life; D019265:Spectroscopy, Near-Infrared; D013647:Task Performance and Analysis; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D014705:Verbal Behavior / Q000502:physiology
chemical_list: D010108:Oxyhemoglobins