title: Surface curvature in triply-periodic minimal surface architectures as a distinct design parameter in preparing advanced tissue engineering scaffolds.
abstract: Reproduction of the anatomical structures and functions of tissues using cells and designed 3D scaffolds is an ongoing challenge. For this, scaffolds with appropriate biomorphic surfaces promoting cell attachment, proliferation and differentiation are needed. In this study, eight triply-periodic minimal surface (TPMS)-based scaffolds were designed using specific trigonometric equations, providing the same porosity and the same number of unit cells, while presenting different surface curvatures. The scaffolds were fabricated by stereolithography using a photocurable resin based on the biocompatible, biodegradable and rubber-like material, poly(trimethylene carbonate) (PTMC). A numerical approach was developed to calculate the surface curvature distributions of the TPMS architectures. Moreover, the scaffolds were characterized by scanning electron microscopy, micro-computed tomography and water permeability measurements. These original scaffold architectures will be helpful to decipher the biofunctional role of the surface curvature of scaffolds intended for tissue engineering applications.
authors.affiliation: MIRA Institute for Biomedical Technology and Technical Medicine, Department of Biomaterials Science and Technology, Faculty of Science and Technology, University of Twente, 7500 AE Enschede, The Netherlands. Institut Charles Gerhardt de Montpellier UMR5253 CNRS-UM-ENSCM-Equipe Ingénierie et Architectures Macromoléculaires, Université de Montpellier, F-34095 Montpellier, France.
authors.forename: Sébastien B G
authors.initials: SBG
authors.lastname: Blanquer
authors.forename: Maike
authors.initials: M
authors.lastname: Werner
authors.forename: Markus
authors.initials: M
authors.lastname: Hannula
authors.forename: Shahriar
authors.initials: S
authors.lastname: Sharifi
authors.forename: Guillaume P R
authors.initials: GPR
authors.lastname: Lajoinie
authors.forename: David
authors.initials: D
authors.lastname: Eglin
authors.forename: Jari
authors.initials: J
authors.lastname: Hyttinen
authors.forename: André A
authors.initials: AA
authors.lastname: Poot
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Grijpma
mesh_terms: D004146:Dioxanes / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008962:Models, Theoretical; D016011:Normal Distribution; D010539:Permeability; D016062:Porosity; D015203:Reproducibility of Results; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014867:Water; D055114:X-Ray Microtomography
chemical_list: D004146:Dioxanes; D014867:Water; C443643:trimethylene carbonate