title: Corynebacterium propinquum endocarditis: a confounding presentation of a rare entity.
abstract: Infective endocarditis is rarely caused by Corynebacterium species. We report a unique case of Corynebacterium propinquum endocarditis in an otherwise healthy individual, and it is the first example of this organism causing culture-negative endocarditis. Conflicting clinical and microbiological data led to the use of sequencing to confirm the causative organism. This case illustrates C. propinquum as a cause of infective endocarditis, and it demonstrates the utility of ancillary molecular diagnostic techniques to identify etiologic agents in difficult cases of infective endocarditis.
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: bryan.rea@uphs.upenn.edu.
authors.forename: Bryan
authors.initials: B
authors.lastname: Rea
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Jaleah
authors.initials: J
authors.lastname: Hawkins
authors.affiliation: Department of Pathology and Laboratory Medicine, Penn Presbyterian Medical Center, Pennsylvania, Philadelphia, PA, USA.
authors.forename: Htun
authors.initials: H
authors.lastname: Min
authors.affiliation: Department of Medicine, Penn Presbyterian Medical Center, Pennsylvania, Philadelphia, PA, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Maniglia
authors.affiliation: Department of Medicine, Penn Presbyterian Medical Center, Pennsylvania, Philadelphia, PA, USA.
authors.forename: Naasha
authors.initials: N
authors.lastname: Talati
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Laurel
authors.initials: L
authors.lastname: Glaser
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001021:Aortic Valve / Q000187:drug effects / Q000382:microbiology* / Q000473:pathology; D002443:Ceftriaxone / Q000627:therapeutic use; D003352:Corynebacterium / Q000145:classification* / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D003354:Corynebacterium Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D021521:Ribotyping; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone
keywords: 16S Ribosomal sequencing; Corynebacterium propinquum; Infective endocarditis