title: Emerging roles of lipid metabolism in cancer metastasis.
abstract: Cancer cells frequently display fundamentally altered cellular metabolism, which provides the biochemical foundation and directly contributes to tumorigenicity and malignancy. Rewiring of metabolic programmes, such as aerobic glycolysis and increased glutamine metabolism, are crucial for cancer cells to shed from a primary tumor, overcome the nutrient and energy deficit, and eventually survive and form metastases. However, the role of lipid metabolism that confers the aggressive properties of malignant cancers remains obscure. The present review is focused on key enzymes in lipid metabolism associated with metastatic disease pathogenesis. We also address the function of an important membrane structure-lipid raft in mediating tumor aggressive progression. We enumerate and integrate these recent findings into our current understanding of lipid metabolic reprogramming in cancer metastasis accompanied by new and exciting therapeutic implications.
authors.affiliation: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China. luocsu@hotmail.com.|Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China. luocsu@hotmail.com.|Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, China. luocsu@hotmail.com.
authors.forename: Xiangjian
authors.initials: X
authors.lastname: Luo
authors.affiliation: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.|Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, China.
authors.forename: Can
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.|Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, China.
authors.forename: Zheqiong
authors.initials: Z
authors.lastname: Tan
authors.affiliation: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.|Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, China.
authors.forename: Namei
authors.initials: N
authors.lastname: Li
authors.affiliation: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.|Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, China.
authors.forename: Min
authors.initials: M
authors.lastname: Tang
authors.affiliation: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.|Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.|Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, China.
authors.forename: Lifang
authors.initials: L
authors.lastname: Yang
authors.affiliation: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China. ycao98@vip.sina.com.|Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China. ycao98@vip.sina.com.|Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, China. ycao98@vip.sina.com.
authors.forename: Ya
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D050356:Lipid Metabolism; D021962:Membrane Microdomains / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*
keywords: Lipid metabolism; Lipid raft; Metastasis