title: The Mechanisms and Potential Impact of Stem Cell Activation in Skin Rejuvenation: An Evidence-Based Analysis.
abstract: <p>Stem cells can propagate indefinitely in an undifferentiated state; or, with appropriate signals, differentiate into various types of mature cells. Strong interest in stem cell therapies for degenerative diseases has extended to skin aging, itself a degenerative process. This article reviews mechanisms of skin aging, and enables an evidence-based approach to topical skin rejuvenation - specifically, to formulations labeled as stem cell products.</p> <p><em>J Drugs Dermatol. 2017;16(4):378-384.</em></p>.
authors.forename: Hema
authors.initials: H
authors.lastname: Sundaram
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001688:Biological Products / Q000008:administration & dosage / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects; D016922:Cellular Senescence / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D019317:Evidence-Based Medicine; D049851:Gastropoda / Q000737:chemistry; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000502:physiology; D012060:Rejuvenation; D037761:Sirtuins / Q000502:physiology; D015595:Skin Aging / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D013234:Stem Cells / Q000187:drug effects* / Q000502:physiology
chemical_list: D001688:Biological Products; D037761:Sirtuins