title: Plasma exchange for the patients with dilated cardiomyopathy in children is safe and effective in improving both cardiac function and daily activities.
abstract: Autoantibodies against cardiac proteins play an important role in the development of dilated cardiomyopathy (DCM). The efficacy and safety of apheresis such as immunoadsorption (IA) or plasma exchange (PE) to remove such antibodies have been reported in adult DCM patients. However, apheresis for pediatric DCM has not been performed because of technical difficulty due to relatively low blood volume and instability of hemodynamics. As we have experiences of preforming apheresis on hemodynamically unstable children, we have preformed ten courses of PE on seven child DCM patients including both patients in chronic and acute phase to assess the safety and efficacy to PE. Under general anesthesia, the patients were administered PE three times during 3 days as 1 course. Simultaneously, continuous hemodiafiltration (CHDF) was performed in series with the PE circuit to stabilize hemodynamic status and to minimize the adverse effects of PE. The changes in LVEF, CTR, mBP, the dosage of furosemide and NYHA were assessed before and after the procedure of PE. There were no severe adverse effects such as systemic bleeding or refractory hypotension due to apheresis. Echocardiography showed that mean baseline LVEF was 24.3 ± 7.8%. Mean LVEF significantly increased 1 week after PE to 30.5 ± 12.5%. CTR significantly decreased after PE. Mean BP significantly increased 1 month after PE (54.5 ± 10.7 to 60.7 ± 9.8 mmHg). NYHA improved after PE significantly (NYHA; 3.4 ± 1.1 to 2.5 ± 1.1). PE is safe and effective in improving both cardiac function and daily activities.
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Yamanashi School of Medicine, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan. tmoriguchi@yamanashi.ac.jp.
authors.forename: Takeshi
authors.identifier: http://orcid.org/0000-0002-7515-4173
authors.initials: T
authors.lastname: Moriguchi
authors.affiliation: Department of Pediatrics, University of Yamanashi School of Medicine, Chuo, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Koizumi
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Yamanashi School of Medicine, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsuda
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Yamanashi School of Medicine, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Harii
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Yamanashi School of Medicine, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Goto
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Yamanashi School of Medicine, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Harada
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Yamanashi School of Medicine, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Sugawara
authors.affiliation: Department of Pediatrics, University of Yamanashi School of Medicine, Chuo, Japan.
authors.forename: Minako
authors.initials: M
authors.lastname: Hoshiai
authors.affiliation: Department of Pediatrics, University of Yamanashi School of Medicine, Chuo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kise
authors.affiliation: Department of Cardiology, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.
authors.forename: Akiyasu
authors.initials: A
authors.lastname: Baba
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D010951:Plasma Exchange / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Apheresis; CHDF; Child; Dilated cardiomyopathy; Plasma exchange