title: Plasma PCSK9 concentrations during the course of nondiabetic chronic kidney disease: Relationship with glomerular filtration rate and lipid metabolism.
abstract: The association between proprotein convertase subtilisin/kexin type 9 (PCSK9), a critical regulator of low-density lipoprotein (LDL) metabolism, and kidney function is a matter of debate.
  
  
  
  We aimed to assess the association of circulating PCSK9 concentrations with both glomerular filtration rate (eGFR) and serum lipid parameters in nondiabetic patients with chronic kidney disease (CKD).
  
  
  
  Fasting plasma PCSK9 concentrations were measured by ELISA in 94 nondiabetic nondialysis CKD (ND-CKD) patients not receiving statins, at different stages of CKD.
  
  
  
  Plasma PCSK9 levels were associated neither to eGFR (P = .770) nor to proteinuria (P = .888) at several stages of CKD. In addition, plasma PCSK9 levels did not vary significantly between the different CKD stages. Plasma PCSK9 concentrations were positively correlated with apolipoprotein B (r = 0.221; P = .03) and triglycerides (r = 0.211; P = .04) but not with total cholesterol, calculated LDL-cholesterol, HDL cholesterol, lipoprotein(a), or CRP.
  
  
  
  In a homogeneous population of nondiabetic subjects without lipid-lowering therapy, plasma PCSK9 concentrations are not associated to eGFR at several stages of CKD. These data suggest that kidney function per se does not impact significantly PCSK9 metabolism.
authors.affiliation: Département de Biochimie et Hormonologie, CHU de Montpellier, Montpellier, France; Institut de Recherche et de Formation en Dialyse, Montpellier, France; PhyMedExp, Université de Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Morena
authors.affiliation: L'Institut du Thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Le May
authors.affiliation: Service de Néphrologie, CHU de Montpellier, Montpellier, France.
authors.forename: Leila
authors.initials: L
authors.lastname: Chenine
authors.affiliation: L'Institut du Thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Arnaud
authors.affiliation: Département de Biochimie et Hormonologie, CHU de Montpellier, Montpellier, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Dupuy
authors.affiliation: L'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Pichelin
authors.affiliation: Service de Néphrologie, CHU de Montpellier, Montpellier, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Leray-Moragues
authors.affiliation: AIDER, Montpellier, France.
authors.forename: Lotfi
authors.initials: L
authors.lastname: Chalabi
authors.affiliation: Institut de Recherche et de Formation en Dialyse, Montpellier, France; Université de Montpellier, Néphrologie, Montpellier, France; Fresenius Medical Care, Bad Homburg, Germany.
authors.forename: Bernard
authors.initials: B
authors.lastname: Canaud
authors.affiliation: Département de Biochimie et Hormonologie, CHU de Montpellier, Montpellier, France; Institut de Recherche et de Formation en Dialyse, Montpellier, France; PhyMedExp, Université de Montpellier, INSERM U1046, CNRS UMR 9214, Montpellier, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.affiliation: L'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, France. Electronic address: bertrand.cariou@univ-nantes.fr.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Cariou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D000071449:Proprotein Convertase 9 / Q000097:blood*; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D014280:Triglycerides / Q000097:blood
chemical_list: D001055:Apolipoproteins B; D014280:Triglycerides; C472125:PCSK9 protein, human; D000071449:Proprotein Convertase 9
keywords: Chronic kidney disease; LDL cholesterol; PCSK9; Triglycerides; eGFR