title: The effect of different dose regimens of tranexamic acid in reducing blood loss during hip surgery.
abstract: OBJECTIVE
  Antifibrinolytics may help bleeding in orthopaedic surgeries. The present study was undertaken to compare two dose regimens of tranexamic acid (TA) on perioperative blood loss in patients undergoing hip surgeries.
  
  
  METHODS
  In a prospective, randomised, controlled study, 59 patients scheduled for hip surgery were divided into Group C: receiving normal saline (n- 20), Group B: receiving single dose of TA (10 mg/kg) (n- 21), and Group I: receiving a bolus (10 mg/kg) plus infusion (1 mg/kg/h) of TA up to 4 h postoperatively (n- 18). Blood loss, haemoglobin and allogeneic blood transfusions were compared between the groups. For parametric data,Pwas calculated by ANOVA. Intergroup comparison was done bypost hocanalysis with Bonferroni test.P< 0.05 was considered significant.
  
  
  RESULTS
  The intra-operative blood loss was lower in the patients who received TA (525 ± 150, 456 ± 156 and 400 ± 133 ml in Group C, B and I respectively;P= 0.05). The 6th hourly drain collection in Group I was lower than Group B and C (41 ± 18, 46 ± 14 and 31 ± 14 ml in Group C, B, and I respectively;P= 0.018). The blood loss at 24 h was less in groups receiving TA (146 ± 32, 120 ± 76, 107 ± 37 ml for Group C, B and I, respectively;P= 0.02). The requirement of blood transfusions was lower in Group I.
  
  
  CONCLUSIONS
  A bolus of tranexamic acid followed by infusion is more useful than a single dose in decreasing perioperative blood loss in patients undergoing hip surgeries. It reduces allogenic blood transfusion without increasing risk of thromboembolic events.
authors.affiliation: Department of Anaesthesiology and Critical Care, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Thipparampall
authors.affiliation: Department of Anaesthesiology and Critical Care, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: Indira
authors.initials: I
authors.lastname: Gurajala
authors.affiliation: Department of Anaesthesiology and Critical Care, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
authors.forename: R
authors.initials: R
authors.lastname: Gopinath
keywords: Blood loss; hip surgeries; tranexamic acid