title: High Interleukin-10 Expression in Type 2 T Helper Cells in Septic Patients.
abstract: Interleukin (IL)-10 response is associated with mortality in patients with sepsis. IL-10 is primarily produced by monocytes and type 2 T helper (Th2) cells. The aim of this study was to investigate differences in IL-10 production between monocytes and Th2 cells in patients with sepsis. Forty patients with sepsis and 35 healthy controls were enrolled. Cytokine expressions in peripheral blood mononuclear cells (PBMCs) were measured by flow cytometry. The IL-10 expression in the Th2 cells of the septic patients was higher than in the healthy controls, but the expression of IL-10 in the monocytes of the septic patients was lower than in the healthy controls. After regression analysis, IL-10 expression in Th2 cells was positively associated with sepsis, but IL-10 expression in monocytes was not associated with sepsis or shock. In conclusion, the production of IL-10 in Th2 cells was higher in the patients with sepsis.
authors.affiliation: a Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital , Keelung , Taiwan.|b Chang Gung University College of Medicine , Taoyuan , Taiwan.
authors.forename: Huang-Pin
authors.initials: HP
authors.lastname: Wu
authors.affiliation: a Division of Pulmonary, Critical Care and Sleep Medicine, Chang Gung Memorial Hospital , Keelung , Taiwan.
authors.forename: Chien-Ming
authors.initials: CM
authors.lastname: Chu
authors.affiliation: b Chang Gung University College of Medicine , Taoyuan , Taiwan.|c Department of Thoracic Medicine , Chang Gung Memorial Hospital , Linkou , Taiwan.
authors.forename: Kuo-Chin
authors.initials: KC
authors.lastname: Kao
authors.affiliation: d Department of Medical Laboratory , Chang Gung Memorial Hospital , Keelung , Taiwan.
authors.forename: Shu-Huan
authors.initials: SH
authors.lastname: Huang
authors.affiliation: e Department of Chemistry , National Chung-Hsing University , Taichung , Taiwan.
authors.forename: Duen-Yau
authors.initials: DY
authors.lastname: Chuang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D018805:Sepsis / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D016753:Interleukin-10
keywords: Interleukin-10; monocytes; sepsis; type 2 T helper cells