title: Highly Tigecycline-Resistant Klebsiella pneumoniae Sequence Type 11 (ST11) and ST147 Isolates from Companion Animals.
abstract: In this study, we characterized two tigecycline-resistantKlebsiella pneumoniaeisolates from dog urine samples. The isolates were genetically unrelated, belonging to sequence type 11 (ST11) and ST147, both classically related to human isolates. To the best of our knowledge, this is the first identification of tigecycline-resistant isolates from animals. We unveil here the worrisome circulation among animals of bacterial clones resistant to this last-resort antibiotic.
authors.affiliation: Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Ovejero
authors.affiliation: Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Escudero
authors.affiliation: Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Thomas-Lopez
authors.affiliation: Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hoefer
authors.affiliation: Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Moyano
authors.affiliation: Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Montero
authors.affiliation: Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.|Hospital Clínico Veterinario, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Martin-Espada
authors.affiliation: Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain bgzorn@ucm.es.
authors.forename: Bruno
authors.initials: B
authors.lastname: Gonzalez-Zorn
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D000078304:Tigecycline; D008911:Minocycline
keywords: Klebsiella; drug efflux; efflux pumps; pets; plasmids; tigecycline