title: Comparison of Iodixanol and Iopromide in Patients With Renal Insufficiency and Congestive Heart Failure Undergoing Coronary Angiography by Hemodynamic Monitoring.
abstract: We investigated the impact of contrast media (CM) with different osmolality on cardiac preload in patients with chronic kidney disease (CKD) and congestive heart failure (CHF). Patients with CKD and CHF were equally randomized to receive either iso-osmolar contrast media (IOCM) iodixanol or low-osmolar contrast media iopromide. We measured cardiac preload indexes by invasive hemodynamic monitoring before and after CM injection. Major adverse cardiac events postprocedures were recorded. Increase in extravascular lung water index was only seen in the iopromide group ( P < .001), while global end diastolic index and central venous pressure were all significantly increased from baseline in the both groups ( P < .001, respectively), and the increase in cardiac preload indexes was significantly greater in the iopromide group than in the iodixanol group ( P < 0.001). The overall incidence of acute heart failure was more frequently observed in the iopromide group ( P = 0.027). Low-osmolar contrast media iopromide significantly increased cardiac preload in patients with CKD and CHF undergoing cardiac catheterization procedures compared with IOCM iodixanol.
authors.affiliation: 1 Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Qian
authors.affiliation: 1 Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Yang
authors.affiliation: 1 Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.affiliation: 1 Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
authors.affiliation: 1 Department of Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Yun-Dai
authors.initials: YD
authors.lastname: Chen
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage* / Q000009:adverse effects*; D017023:Coronary Angiography; D005260:Female; D006333:Heart Failure / Q000150:complications*; D000074743:Hemodynamic Monitoring; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010865:Pilot Projects; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000150:complications*; D013318:Stroke Volume / Q000187:drug effects*; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C038192:iopromide; C044834:iodixanol
keywords: chronic kidney disease; congestive heart failure; contrast media; coronary angiography; iodixanol; iopromide; osmolality