title: The Utility of Ovotransferrin and Ovotransferrin-Derived Peptides as Possible Candidates in the Clinical Treatment of Cardiovascular Diseases.
abstract: Several of the most prevalent etiological factors which contribute towards global death rates are associated with cardiovascular diseases (CVDs), which include a range of conditions such as angina, rheumatic heart disease, and venous thrombosis. Extensive research has been conducted into the role played by oxidative stress and inflammation in the functional transformations associated with the progression of CVDs, while the research findings from these investigations have been both fruitful and informative. In view of the adverse secondary effects that result from the clinical administration of many synthetic medications, research which explored the treatment of severe and long-lasting conditions, including CVDs, has primarily centered on the potential benefits displayed by natural agents, one of which is food protein-based bioactive peptides. Most importantly, previous research has revealed the possible benefits associated with these products' anti-inflammatory and antioxidant characteristics. In light of these considerations, this paper aims to review the degree to which ovotransferrin (otrf, also referred to as conalbumin) and otrf-derived peptides, including IRW, IQW, and KVREGT, are, by virtue of their anti-inflammatory and antioxidant characteristics, viable treatment agents for endothelial dysfunction and the prevention of CVD.
authors.affiliation: College of Bioscience and Biotechnology and College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Chen
authors.affiliation: College of Bioscience and Biotechnology and College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Jiang
authors.affiliation: College of Bioscience and Biotechnology and College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
authors.forename: Hanhui
authors.initials: H
authors.lastname: Peng
authors.affiliation: College of Bioscience and Biotechnology and College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
authors.forename: Xiaosong
authors.identifier: 0000-0003-4803-8289
authors.initials: X
authors.lastname: Wu
authors.affiliation: College of Bioscience and Biotechnology and College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China; Hunan Province University Key Laboratory for Agricultural Biochemistry and Biotransformation, Hunan Agricultural University, Changsha 410128, China; Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China.
authors.forename: Jun
authors.identifier: 0000-0001-9532-8444
authors.initials: J
authors.lastname: Fang
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000517:prevention & control* / Q000628:therapy*; D003207:Conalbumin / Q000378:metabolism / Q000502:physiology*; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D010047:Ovalbumin / Q000235:genetics / Q000494:pharmacology*; D010455:Peptides / Q000235:genetics / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010455:Peptides; D003207:Conalbumin; D010047:Ovalbumin