title: Lymphoplasmacytic Lymphoma Presenting with Diarrhea and Joint Pain Which was Successfully Diagnosed by an MYD88 Mutation Analysis.
abstract: A 55-year-old man presented to our department with diarrhea, weight loss, fatigability, and polyarthralgia. Blood tests revealed elevated soluble interleukin-2 receptor levels and IgG-type M protein positivity, without any findings that were suggestive of collagen disease. After computed tomography (CT) detected enlarged lymph nodes in the abdominal para-aortic region, lymphoma was suspected. CT-guided needle biopsy of the lymph node did not help to achieve a definitive diagnosis; however, a bone marrow test showed the pathological features of B-cell lymphoma. A genetic examination detected a MYD88 L265P mutation; the mutation analysis was valuable in diagnosing lymphoplasmacytic lymphoma in a IgM-type M protein-negative patient.
authors.affiliation: Department of Hematology, Ibaraki Prefectural Central Hospital, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Fukushima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okoshi
authors.forename: Keiko
authors.initials: K
authors.lastname: Fukazawa
authors.forename: Mayuko
authors.initials: M
authors.lastname: Koshino
authors.forename: Shingo
authors.initials: S
authors.lastname: Ishiguro
authors.forename: Shoichi
authors.initials: S
authors.lastname: Mitsuhashi
authors.forename: Hitoaki
authors.initials: H
authors.lastname: Saitoh
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Iijima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kojima
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Hori
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D006023:Glycoproteins / Q000096:biosynthesis; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics*; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology
chemical_list: D006023:Glycoproteins; D053594:Myeloid Differentiation Factor 88; D015375:Receptors, Interleukin-2; C023587:protein M (glycoprotein)