title: Frequency Specific Effects ofApoE ε4 Allele on Resting-State Networks in Nondemented Elders.
abstract: We applied resting-state functional magnetic resonance imaging (fMRI) to examine the Apolipoprotein E (ApoE)ε4 allele effects on functional connectivity of the default mode network (DMN) and the salience network (SN). Considering the frequency specific effects of functional connectivity, we decomposed the brain network time courses into two bands: 0.01-0.027 Hz and 0.027-0.08 Hz. All scans were acquired by the Alzheimer's Disease Neuroscience Initiative (ADNI). Thirty-two nondemented subjects were divided into two groups based on the presence (n= 16) or absence (n= 16) of theApoE ε4 allele. We explored the frequency specific effects ofApoE ε4 allele on the default mode network (DMN) and the salience network (SN) functional connectivity. Compared toε4 noncarriers, the DMN functional connectivity ofε4 carriers was significantly decreased while the SN functional connectivity ofε4 carriers was significantly increased. Many functional connectivities showed significant differences at the lower frequency band of 0.01-0.027 Hz or the higher frequency band of 0.027-0.08 Hz instead of the typical range of 0.01-0.08 Hz. The results indicated a frequency dependent effect of resting-state signals when investigating RSNs functional connectivity.
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liang
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China.
authors.forename: Jing
authors.identifier: 0000-0002-8794-7832
authors.initials: J
authors.lastname: Wei
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China.
authors.forename: Chunlin
authors.identifier: 0000-0002-4437-558X
authors.initials: C
authors.lastname: Li
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China.
authors.forename: Xu
authors.identifier: 0000-0002-4354-5591
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
authors.forename: Alzheimer's Disease
authors.initials: AD
authors.lastname: Neuroimaging Initiative
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000235:genetics* / Q000503:physiopathology; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology
chemical_list: D001057:Apolipoproteins E