title: On gonads and gadflies: the estrus angle.
abstract: The first sex steroid to be crystallized was the vertebrate ovarian hormone, estrone - a less potent metabolite of 17β-estradiol, which in mammals stimulates the female urge to mate (estrus). The gadfly (Greekoistros) lent its name to the process of estrus, as an insect that bites and torments in classical Greek mythology. With the purification and crystallization of a moult-inducing steroid (ecdysone) from insects, an interesting parallel emerged between mating and moulting in lower mammals and arthropods. Ecdysterone (potent ecdysone metabolite) has anabolic effects in mammalian muscle cells that can be blocked by selective estrogen receptor antagonists. Insects utilize ecdysteroids in similar ways that vertebrates use estrogens, including stimulation of oocyte growth and maturation. Ecdysteroids also modify precopulatory insect mating behaviour, further reinforcing the gonad-gadfly/mate-moult analogy.
authors.affiliation: Medical Research Council Centre for Reproductive HealthUniversity of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom steve.hillier@ed.ac.uk.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Hillier
mesh_terms: D045930:Anabolic Agents; D000818:Animals; D004175:Diptera; D004440:Ecdysone / Q000502:physiology; D026461:Ecdysteroids / Q000502:physiology; D004441:Ecdysterone / Q000502:physiology; D004967:Estrogens / Q000502:physiology; D004971:Estrus / Q000502:physiology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006066:Gonads / Q000378:metabolism*; D006801:Humans
chemical_list: D045930:Anabolic Agents; D026461:Ecdysteroids; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D004440:Ecdysone; D004441:Ecdysterone
keywords: cholesterol; development; estrogen; female reproduction; steroids