title: Genetic variations of TLR5 gene interacted with Helicobacter pylori infection among carcinogenesis of gastric cancer.
abstract: Gastric cancer (GC) ranks the second prevalent cancer type and the second cancer-related death in China. However, the precise mechanisms of GC development remain poorly understood. Chronic infection with Helicobacter pylori is the strongest identified risk factor for GC. Toll-like receptor (TLR) genes, which play critical roles in Helicobacter pylori induced chronic inflammation, may also be implicated in GC susceptibility. TLR5 signaling deficiency could deregulate a cascade of inflammatory events. In current study, we systematically evaluated genetic variations of TLR5, and their interaction with Helicobacter pylori infection among carcinogenesis of gastric cancer, using a large case-controls study among Chinese population. Minor alleles of three SNPS, including rs5744174 (P = 0.001), rs1640827 (P = 0.005), and rs17163737 (P = 0.004), were significantly associated with increased GC risk (OR ranged from 1.20-1.24). Significant interactions with Helicobacter pylori infection were also identified for rs1640827 (P for interaction = 0.009) and rs17163737 (P for interaction = 0.006). These findings suggest that genetic variants in TLR5 may modify the role of Helicobacter pylori infection in the process of causing GC.
authors.affiliation: Department of Oncology, The Second Affiliated Hospital of Fujian Medical University, China.
authors.forename: Tianwen
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Oncology, The Second Affiliated Hospital of Fujian Medical University, China.
authors.forename: Deqiang
authors.initials: D
authors.lastname: Fu
authors.affiliation: Department of Thyroid and Breast, Huai'an First People's Hospital, Nanjing Medical University, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Oncology, The Second Affiliated Hospital of Fujian Medical University, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Oncology, The Second Affiliated Hospital of Fujian Medical University, China.
authors.forename: Jianguang
authors.initials: J
authors.lastname: Lin
authors.affiliation: No. 2 People's Hospital of Henan Province, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Thoracic Surgery, Huai'an First People's Hospital, Nanjing Medical University, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications* / Q000821:virology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology; D051198:Toll-Like Receptor 5 / Q000235:genetics*
chemical_list: D051198:Toll-Like Receptor 5
keywords: Helicobacter pylori; TLR5; gastric cancer; genetic; variation