title: Biological Evidence for Paradoxical Improvement of Psychiatric Disorder Symptoms by Addictive Drugs.
abstract: Addiction biology has focused on the mechanisms of the positive and negative reinforcing actions of addictive drugs but neglected potential benefits. Two new studies provide the first insights into a neurobiology of psychoactive drug instrumentalization. This may help us design better models for addiction neuroscience and opens a new dimension for the development of personalized pharmacotherapy of drug addiction.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address: Christian.Mueller@uk-erlangen.de.
authors.forename: Christian P
authors.initials: CP
authors.lastname: Müller
authors.affiliation: Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000523:psychology*; D058999:Drug-Seeking Behavior / Q000502:physiology*; D006801:Humans; D009446:Neurobiology; D011582:Psychological Theory; D011619:Psychotropic Drugs / Q000008:administration & dosage*; D019966:Substance-Related Disorders / Q000523:psychology*
chemical_list: D011619:Psychotropic Drugs
keywords: alcohol; depression; drug instrumentalization; nicotine; schizophrenia