title: [Application of synthetic and semisynthetic polymers (Kollidon K30 and hydroxypropylmethylcellulose) as carriers of ketoprofen in solid oral prolonged-release dosage forms].
abstract: BACKGROUND
  One of the most important challenges of the modern technology of solid oral dosage forms is to increase the effectiveness of the drug, reduce side effects and improve the comfort of use. One way to obtain such effects are prolonged release dosage forms.
  
  
  OBJECTIVE
  The aim of the study was to investigate the suitability of polymers (synthetic - Kollidon K30 and semisynthetic - hydroxypropyl methylcellulose), and calcium hydrogen phosphate dihydrate - as an inorganic insoluble filler - in the construction of the matrices of the solid oral dosage forms containing non-steroidal anti-inflammatory drugs (NSAIDs). We used ketoprofen as a model active ingredient.
  
  
  METHODS
  Ketoprofenum, hydroxypropylmethylcellulose, calcium hydrogen phosphate, kollidon K30, magnesium stearate. Incorporation. Studies of the tablet mass. Direct tabletting. Studies of the pharmacopoeial parameters and pharmaceutical availability. Measurements of the viscosity of 1% solution of HPMC and Kollidon K30. Approximation of the results.
  
  
  RESULTS
  We obtained three versions (formulations) of the matrices. The results of the granulometric research on tablet formulations were consistent with the standards. The results of morphological studies and pharmacopoeial tablets were consistent with the standards. The best results were obtained for the release formulations containing HPMC and calcium hydrogenphoshate. Kollidon K30 accelerated the release of ketoprofen from tablets of formulation I.
  
  
  CONCLUSIONS
  The model system of preformulation studies showed the usefulness of HPMC and Kollidon K30 in the technology of hydrophilic matrices with ketoprofen.
authors.affiliation: Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Linka
authors.affiliation: Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kot
authors.affiliation: Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
authors.forename: Michał
authors.initials: M
authors.lastname: Kołodziejczyk
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry; D003692:Delayed-Action Preparations; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry; D065347:Hypromellose Derivatives / Q000737:chemistry*; D007660:Ketoprofen / Q000737:chemistry / Q000493:pharmacokinetics*; D007700:Kinetics; D011205:Povidone / Q000737:chemistry*; D013607:Tablets; D014783:Viscosity
chemical_list: D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D065347:Hypromellose Derivatives; D007660:Ketoprofen; D011205:Povidone; C485829:calcium phosphate, dibasic, anhydrous
keywords: Kollidon K30; hydroxypropylmethylcellulose; ketoprofenum; matrix; tablets prolongatum