title: [Is a once-daily dose of furosemide effective? Literature study into rational for dosing of short-acting diuretic].
abstract: - Furosemide is a widely used short-acting diuretic with a steep dose-response curve.- Furosemide is commonly prescribed once daily, but because of its short-acting nature it is questionable if a once-daily regiment is effective.- Different physiological and pathophysiological principles influence the effect and period of efficacy of furosemide.- Studies in both healthy subjects and different patient categories do demonstrate efficacy of furosemide once daily, but also that furosemide prescribed twice daily is more effective.- It is advised to combine furosemide treatment with a sodium-restricted diet, because this enhances the effects of the diuretic treatment.
authors.affiliation: Medisch Centrum Leeuwarden, afd. Intensive Care, Leeuwarden.
authors.forename: M M C O
authors.initials: MM
authors.lastname: van IJzendoorn
authors.forename: E C
authors.initials: EC
authors.lastname: Boerma
authors.forename: G J
authors.initials: GJ
authors.lastname: Navis
mesh_terms: D004232:Diuretics / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D004232:Diuretics; D005665:Furosemide