title: Anti-Mullerian hormone as a parameter for endometrial trauma in Asherman syndrome: A retrospective data analysis.
abstract: Recently, the endometrium has been identified as a repository for Anti-Mullerian hormone (AMH), with endometrial masses associated with AMH serum levels. We aimed to compare AMH levels, as well as other parameters for ovarian reserve, in women with endometrial trauma due to Asherman syndrome (AS) and matched controls. In a retrospective study, nine women with hysteroscopically confirmed AS were compared to nine matched controls. Follicle-stimulating hormone, luteinizing hormone, and estradiol levels did not differ between women with and without AS, whereas significantly lower AMH levels were found in patients (median 0.50pg/mL; IQR 0.25-0.75) than in controls (median 1.14pg/mL; IQR 0.63-1.77; p=0.026). The results suggest that decreased AMH levels in patients with AS do not necessarily indicate decreased ovarian reserve. The study is limited by the small sample size, and, thus, future research on the role of AMH in endometrial tissue and function are necessary to clarify the importance of these findings.
authors.affiliation: Clinical Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria; Department of Obstetrics and Gynecology, Saint John of God Hospital Eisenstadt, Eisenstadt, Burgenland, Austria.
authors.forename: Regina
authors.initials: R
authors.lastname: Promberger
authors.affiliation: Clinical Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria. Electronic address: johannes.ott@meduniwien.ac.at.
authors.forename: Johannes
authors.initials: J
authors.lastname: Ott
mesh_terms: D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers; D016022:Case-Control Studies; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006175:Gynatresia / Q000097:blood*; D006801:Humans; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: Anti-Mullerian hormone; Asherman syndrome; Endometrium; Intrauterine adhesions