title: The Coexistence of Multiple Myeloma-associated Amyloid Light-chain Amyloidosis and Fabry Disease in a Hemodialysis Patient.
abstract: Fabry disease (FD) is an inherited lysosomal disorder caused by an X-linked α-galactosidase A deficiency. We report the case of a 50-year-old male FD patient on hemodialysis who presented with macroglossia-related speaking difficulty and gastrointestinal symptoms. An endoscopic analysis revealed multiple gastric ulcers, and a histological examination led to a diagnosis of amyloid light-chain amyloidosis. Serum free light-chain and bone marrow analyses detected multiple myeloma (MM). Treatment with bortezomib and dexamethasone significantly improved the patient's symptoms. This is the first case to demonstrate a potential pathogenic relationship between FD and MM. The similar gastrointestinal manifestations might have contributed to the diagnostic difficulty.
authors.affiliation: Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Japan.
authors.forename: Kensei
authors.initials: K
authors.lastname: Taguchi
authors.forename: Atsuo
authors.initials: A
authors.lastname: Moriyama
authors.forename: Goh
authors.initials: G
authors.lastname: Kodama
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Kei
authors.initials: K
authors.lastname: Fukami
mesh_terms: D000686:Amyloidosis / Q000150:complications*; D000069286:Bortezomib / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D000795:Fabry Disease / Q000150:complications*; D005767:Gastrointestinal Diseases / Q000150:complications*; D006801:Humans; D007147:Immunoglobulin Light Chains; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D006435:Renal Dialysis
chemical_list: D007147:Immunoglobulin Light Chains; D000069286:Bortezomib; D003907:Dexamethasone