title: Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer.
abstract: Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation.
authors.affiliation: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Yue
authors.identifier: 0000-0001-9313-5809
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xiaokun
authors.identifier: 0000-0002-9463-5175
authors.initials: X
authors.lastname: Gang
authors.affiliation: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Chenglin
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Guixia
authors.identifier: 0000-0001-8107-616X
authors.initials: G
authors.lastname: Wang
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology; D002465:Cell Movement; D002986:Clinical Trials as Topic; D048909:Diabetes Complications / Q000628:therapy; D017719:Diabetic Foot / Q000628:therapy*; D016523:Foot Ulcer / Q000628:therapy*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010641:Phenotype; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014945:Wound Healing