title: Effect of Coenzyme Q10 on Radiation Nephropathy in Rats.
abstract: The kidney is one of the most radiosensitive organs in the abdominal cavity and is the dose-limiting structure in cancer patients receiving abdominal or total body irradiation. In the present study, the effect of coenzyme Q10 (CoQ10) on radiation nephropathy was evaluated in rats. A total of 72 rats were equally randomized into 4 groups: Control, CoQ10, irradiation with 10 Gy (RT) + placebo, or RT + CoQ10. The 2 RT groups received single 10 Gy of abdominal irradiation. The 2 CoQ10 groups were supplemented daily with 1 mL of soybean oil containing 10 mg/kg of CoQ10. The RT + placebo and control groups received same dose of soybean oil. After 24 weeks, laboratory and histopathologic findings were compared. The 2 RT groups showed significant increases in blood urea nitrogen (BUN) and creatinine levels and significant pathologic changes such as glomerulosclerosis and tubulointerstitial fibrosis. CoQ10 supplementation resulted in significant reductions of BUN and creatinine levels compared with the RT + placebo group (P < 0.001 and P = 0.038, respectively). CoQ10 treatment significantly attenuated glomerular and tubular changes of irradiated kidney in semiquantitative analysis (P < 0.001 for both). Administration of CoQ10 can alleviate the radiation-induced nephropathy.
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea.
authors.forename: Yongkan
authors.identifier: http://orcid.org/0000-0003-0757-8211
authors.initials: Y
authors.lastname: Ki
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea. rokwt@hanmail.net.
authors.forename: Wontaek
authors.identifier: http://orcid.org/0000-0001-8626-7344
authors.initials: W
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea.
authors.forename: Yong Ho
authors.identifier: http://orcid.org/0000-0002-4362-8426
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea.
authors.forename: Donghyun
authors.identifier: http://orcid.org/0000-0002-8062-4619
authors.initials: D
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea.
authors.forename: Jin Sook
authors.identifier: http://orcid.org/0000-0001-6304-9862
authors.initials: JS
authors.lastname: Bae
authors.affiliation: Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea.
authors.forename: Dahl
authors.identifier: http://orcid.org/0000-0001-5143-3920
authors.initials: D
authors.lastname: Park
authors.affiliation: Department of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Hosang
authors.identifier: http://orcid.org/0000-0003-3960-3469
authors.initials: H
authors.lastname: Jeon
authors.affiliation: Department of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Ju Hye
authors.identifier: http://orcid.org/0000-0002-6758-6822
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Jayoung
authors.identifier: http://orcid.org/0000-0001-6226-8799
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Jiho
authors.identifier: http://orcid.org/0000-0001-8495-0166
authors.initials: J
authors.lastname: Nam
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000528:radiation effects; D003404:Creatinine / Q000097:blood; D019587:Dietary Supplements; D005720:Gamma Rays; D007668:Kidney / Q000473:pathology / Q000528:radiation effects*; D007674:Kidney Diseases / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D015990:Placebo Effect; D051381:Rats; D017207:Rats, Sprague-Dawley; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D014451:Ubiquinone; D003404:Creatinine; C024989:coenzyme Q10
keywords: Coenzyme Q10; Radiation Nephropathy; Radiation Therapy; Rats; Total Body Irradiation