title: Nanotubular topography enhances the bioactivity of titanium implants.
abstract: Surface modification on titanium implants plays an important role in promoting mesenchymal stem cell (MSC) response to enhance osseointegration persistently. In this study, nano-scale TiO2nanotube topography (TNT), micro-scale sand blasted-acid etched topography (SLA), and hybrid sand blasted-acid etched/nanotube topography (SLA/TNT) were fabricated on the surfaces of titanium implants. Although the initial cell adherence at 60 min among TNT, SLA and TNT/SLA was not different, SLA and SLA/TNT presented to be rougher and suppressed the proliferation of MSC. TNT showed hydrophilic surface and balanced promotion of cellular functions. After being implanted in rabbit femur models, TNT displayed the best osteogenesis inducing ability as well as strong bonding strength to the substrate. These results indicate that nano-scale TNT provides favorable surface topography for improving the clinical performance of endosseous implants compared with micro and hybrid micro/nano surfaces, suggesting a promising and reliable surface modification strategy of titanium implants for clinical application.
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xinchun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Wangxiang
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhipei
authors.initials: Z
authors.lastname: Chen
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China; Center of Biomedical Engineering, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Xintao
authors.initials: X
authors.lastname: Shuai
authors.affiliation: Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. Electronic address: anxunwang@yahoo.com.
authors.forename: Anxun
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China. Electronic address: wangyan9@mail.sysu.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D043942:Nanotubes / Q000737:chemistry*; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D019736:Prostheses and Implants; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D019371:Topography, Medical / Q000379:methods*
chemical_list: D014025:Titanium
keywords: Bioactivity; Nanotubular; Titanium implant; Topography