title: [Progress in research on TLR7 gene single nucleotide polymorphisms and copy number variations in autoimmune diseases].
abstract: Autoimmune diseases (AID) are a group of complex disorders due to antibodies acting on self-antigens causing damage to the body. AID has long been considered as the outcome of genetic and environmental interactions. In recent years, studies have shown that increased susceptibility to AID may be associated with single nucleotide polymorphisms and copy number variations of Toll like receptor 7 (TLR7) gene, which provided a clue to further understanding of the pathogenesis of AID. This paper provides a review of the recent advances in understanding of the roles of TLR7 gene single nucleotide polymorphisms and copy number variations in AID.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. zzyfl@163.com.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Xi
authors.forename: Qiming
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Zou
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics*; D056915:DNA Copy Number Variations; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D051199:Toll-Like Receptor 7 / Q000235:genetics*
chemical_list: C495348:TLR7 protein, human; D051199:Toll-Like Receptor 7