title: The prevalence of the variants of the L-ficolin gene (FCN2) in the arctic populations of East Siberia.
abstract: L-ficolin encoded by FCN2 gene is a crucial factor of defence against infection in humans. We studied the prevalence of the two common variants (rs17549193 and rs7851696) in aboriginal and alien populations of the Taymyr-Dolgan-Nenets region of Krasnoyarskiy Kray, East Siberia, Russia (Nenets, Dolgans, Nganasans, Russians). We found a decreased prevalence of the rs17549193*T allele in all aboriginal populations as compared to Russians. Also, its frequency was the lowest in the Nenets among the studied populations, while frequency of the rs7851696*T allele was increased in this population. The results suggest that the Arctic populations of East Siberia are characterised by specificity of genetic make-up responsible for the activity of L-ficolin. Clinical and epidemiological studies are required to discover if these genetic features correlate with the infant infectious morbidity in East Siberian populations.
authors.affiliation: Federal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of medical problems of the North, Partizana Zheleznyaka street, 3G, Krasnoyarsk, Russia, 660022.
authors.forename: Marina V
authors.initials: MV
authors.lastname: Smolnikova
authors.affiliation: Research Institute of Medical Genetics, Tomsk NRMC, 10 Nab. Ushaiki, Tomsk, Russia, 634050.
authors.forename: Maxim B
authors.initials: MB
authors.lastname: Freidin
authors.affiliation: Federal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of medical problems of the North, Partizana Zheleznyaka street, 3G, Krasnoyarsk, Russia, 660022. legise@mail.ru.
authors.forename: Sergey Yu
authors.initials: SY
authors.lastname: Tereshchenko
mesh_terms: D000483:Alleles; D001110:Arctic Regions; D005787:Gene Frequency; D023061:Gene Order; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D037102:Lectins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012800:Siberia; D000097604:Ficolins
chemical_list: D037102:Lectins; D000097604:Ficolins
keywords: Circumpolar area; Ethnic groups; L-ficolin; Newborns; Russia; SNPs