title: Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected withHaemophilus parasuis.
abstract: A comparativein vivopharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected withHaemophilus(H.)parasuisfollowing oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations. Plasma TIL concentrations were determined by a validated high-performance liquid chromatography method with ultraviolet detection at 285 nm. PK parameters were calculated by using WinNonlin software. After TIL administration, the main PK parameters of TIL in healthy andH. parasuis-infected pigs were as follows: Area under the concentration-time curve, maximal drug concentration, half-life of the absorption phase, half-life of the distribution phase, and half-life of the elimination phase were 34.86 ± 9.69vs.28.73 ± 6.18 μgㆍh/mL, 1.77 ± 0.33vs.1.67 ± 0.28 μg/mL, 2.27 ± 0.45vs.2.24 ± 0.44 h, 5.35 ± 1.40vs.4.61 ± 0.35 h, and 43.53 ± 8.17vs.42.05 ± 9.36 h, respectively. These results of this exploratory study suggest that there were no significant differences between the PK profiles of TIL in the healthy andH. parasuis-infected pigs.
authors.affiliation: College of Animal Science and Technology, Tarim University, Alar 843300, China.|Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China.|College of Animal Science & Technology, Shihezi University, Shihezi 832000, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Tarim University, Alar 843300, China.|Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.affiliation: College of Animal Science and Technology, Tarim University, Alar 843300, China.|Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Animal Science and Technology, Tarim University, Alar 843300, China.|Key Laboratory of Tarim Animal Husbandry Science and Technology of Xinjiang Production & Construction Corps, Alar 843300, China.
authors.forename: Xianqiang
authors.initials: X
authors.lastname: Li
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D005260:Female; D006192:Haemophilus Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D044137:Haemophilus parasuis / Q000187:drug effects*; D006207:Half-Life; D008297:Male; D013552:Swine / Q000378:metabolism*; D013553:Swine Diseases / Q000188:drug therapy* / Q000382:microbiology; D015645:Tylosin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D000900:Anti-Bacterial Agents; C052319:tilmicosin; D015645:Tylosin
keywords: Haemophilus parasuis; high pressure liquid chromatography; infected pigs; pharmacokinetics; tilmicosin