title: Mechanisms of cardioprotection via modulation of the immune response.
abstract: Both morbidity and mortality as a result of cardiovascular disease remain significant worldwide and account for approximately 31% of annual deaths in the US. Current research is focused on novel therapeutic strategies to protect the heart during and after ischemic events and from subsequent adverse myocardial remodeling. After cardiac insult, the immune system is activated and plays an essential role in the beginning, development, and resolution of the healing cascade. Uncontrolled inflammatory responses can cause chronic disease and exacerbate progression to heart failure and therefore, constitute a major area of focus of cardiac therapies. In the present overview, we share novel insights and promising therapeutic cardioprotective strategies that target the immune response.
authors.affiliation: The Brody School of Medicine, Department of Physiology, East Carolina University, 600 Moye Blvd, Greenville NC 27834, USA.
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Grilo
authors.affiliation: The Brody School of Medicine, Department of Physiology, East Carolina University, 600 Moye Blvd, Greenville NC 27834, USA.
authors.forename: Patti R
authors.initials: PR
authors.lastname: Shaver
authors.affiliation: The Brody School of Medicine, Department of Physiology, East Carolina University, 600 Moye Blvd, Greenville NC 27834, USA. Electronic address: decastrobrasl14@ecu.edu.
authors.forename: Lisandra E
authors.initials: LE
authors.lastname: de Castro Brás
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D002316:Cardiotonic Agents; D020011:Protective Agents