title: Improving our understanding of thein vivomodelling of psychotic disorders: A protocol for a systematic review and meta-analysis.
abstract: Psychosis represents a set of symptoms against which current available treatments are not universally effective and are often accompanied by adverse side effects. Clinical management could potentially be improved with a greater understanding of the underlying biology and subsequently with the introduction of novel treatments. Since many clinical drug candidates are identified throughin vivomodelling, a deeper understanding of the pre-clinical field, might help us understand why translation of results from animal models to inform mental health clinical practice has so far been weak. We set out to give a shallow, but broad unbiased overview of experiments looking at thein vivomodelling of psychotic disorders using a systematic review and meta-analysis. This protocol describes the exact methodology we propose to follow in order to quantitatively review both studies characterizing a model and those experiments that investigate the effects of novel therapeutic options. We are interested in assessing the prevalence of the reporting of measures to reduce risk of bias, and the internal and external validity of the animal models and outcome measures used to validate these models. This generation of strong empirical evidence has the potential to identify areas for improvement, make suggestions for future research avenues, and ultimately inform what we think we know to improve the current attrition rate between bench and bedside in psychosis research. A review like this will also support the reduction of animal numbers used in research and the refinement of experiments to maximize their value in informing the field.
authors.affiliation: Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK.
authors.forename: Zsanett
authors.initials: Z
authors.lastname: Bahor
authors.affiliation: Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK.
authors.forename: Cristina
authors.initials: C
authors.lastname: Nunes-Fonseca
authors.affiliation: Division of Psychiatry University of Edinburgh, Royal Edinburgh Hospital Edinburgh UK.
authors.forename: Lindsay D G
authors.initials: LD
authors.lastname: Thomson
authors.affiliation: Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK.
authors.forename: Emily S
authors.initials: ES
authors.lastname: Sena
authors.affiliation: Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK.
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Macleod
keywords: animal models; meta‐analysis; protocol; psychosis; systematic review