title: Abiotrophia defectivaendarteritis with infective spondylodiscitis in an adult patient with patent ductus arteriosus.
abstract: Endarteritis is a major complication in patients with patent ductus arteriosus, causing significant morbidity and mortality. We report an adult patient with asymptomatic patent ductus arteriosus and endarteritis involving the main pulmonary artery and secondary infective spondylodiscitis at the L5-S1 intervertebral disc caused byAbiotrophia defectivaA. defectiva, commonly referred to as nutritionally variant streptococci, cannot be identified easily by conventional blood culture techniques from clinical specimens. Its isolation was confirmed by 16S ribosomal RNA sequencing. The patient was successfully managed with a combination of penicillin G and gentamicin, pending surgical repair of the patent ductus arteriosus.
authors.affiliation: Department of General Medicine, Christian Medical College and Hospital, Vellore, India angel_miraclin@yahoo.com.
authors.forename: Angel T
authors.initials: AT
authors.lastname: Miraclin
authors.affiliation: Department of Clinical Microbiology, Christian Medical College and Hospital, Vellore, India.
authors.forename: Susmitha K
authors.initials: SK
authors.lastname: Perumalla
authors.affiliation: Department of General Medicine, Christian Medical College and Hospital, Vellore, India.
authors.forename: Jaifrin
authors.initials: J
authors.lastname: Daniel
authors.affiliation: Department of General Medicine, Christian Medical College and Hospital, Vellore, India.
authors.forename: Sowmya
authors.initials: S
authors.lastname: Sathyendra
mesh_terms: D058835:Abiotrophia / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D015299:Discitis / Q000188:drug therapy / Q000382:microbiology*; D004374:Ductus Arteriosus, Patent / Q000150:complications; D004692:Endarteritis / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008159:Lumbar Vertebrae / Q000382:microbiology; D008875:Middle Aged; D010400:Penicillin G / Q000627:therapeutic use; D012447:Sacrum / Q000382:microbiology; D017423:Sequence Analysis, RNA
chemical_list: D010400:Penicillin G
keywords: Bone and joint infections; Cardiovascular medicine; Infectious diseases