title: Added value and limitations of amyloid-PET imaging: review and analysis of selected cases of mild cognitive impairment and dementia.
abstract: Amyloid-positron emission tomography (PET) imaging of the brain detects elevated amyloid-beta (amyloid-β) neuritic plaques in vivo, which can be helpful in appropriately selected cases of mild cognitive impairment (MCI) and dementia, when Alzheimer's disease remains a possible etiology, after a comprehensive clinical evaluation. We reviewed cases of cognitively impaired patients who underwent amyloid-PET imaging because of diagnostic uncertainty. Pre- and post-PET elements of diagnosis and management were first compared, to assess impact of scan results on clinical decision-making, and then an analysis of those decisions was undertaken in appropriate clinical situations, to delineate the added value and limitations of amyloid-PET imaging. The potential benefits and limitations of this diagnostic tool are important to understand in an era when the utility of such scans in clinical practice is evolving.
authors.affiliation: a Stead Family Memory Center , Banner Alzheimer's Institute , Phoenix , AZ , USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Weidman
authors.affiliation: b Cleo Roberts Memory Center , Banner Sun Health Research Institute , Sun City , AZ , USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Zamrini
authors.affiliation: b Cleo Roberts Memory Center , Banner Sun Health Research Institute , Sun City , AZ , USA.
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Sabbagh
authors.affiliation: b Cleo Roberts Memory Center , Banner Sun Health Research Institute , Sun City , AZ , USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Jacobson
authors.affiliation: a Stead Family Memory Center , Banner Alzheimer's Institute , Phoenix , AZ , USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Burke
authors.affiliation: b Cleo Roberts Memory Center , Banner Sun Health Research Institute , Sun City , AZ , USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Belden
authors.affiliation: b Cleo Roberts Memory Center , Banner Sun Health Research Institute , Sun City , AZ , USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Powell
authors.affiliation: b Cleo Roberts Memory Center , Banner Sun Health Research Institute , Sun City , AZ , USA.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Bhalla
authors.affiliation: a Stead Family Memory Center , Banner Alzheimer's Institute , Phoenix , AZ , USA.
authors.forename: Auttawut
authors.initials: A
authors.lastname: Roontiva
authors.affiliation: a Stead Family Memory Center , Banner Alzheimer's Institute , Phoenix , AZ , USA.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Kuang
authors.affiliation: a Stead Family Memory Center , Banner Alzheimer's Institute , Phoenix , AZ , USA.
authors.forename: Ji
authors.initials: J
authors.lastname: Luo
authors.affiliation: a Stead Family Memory Center , Banner Alzheimer's Institute , Phoenix , AZ , USA.
authors.forename: Kewei
authors.initials: K
authors.lastname: Chen
authors.affiliation: a Stead Family Memory Center , Banner Alzheimer's Institute , Phoenix , AZ , USA.
authors.forename: Garrett
authors.initials: G
authors.lastname: Riggs
authors.affiliation: a Stead Family Memory Center , Banner Alzheimer's Institute , Phoenix , AZ , USA.
authors.forename: William
authors.initials: W
authors.lastname: Burke
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds / Q000378:metabolism; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging* / Q000378:metabolism*; D003704:Dementia / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005026:Ethylene Glycols / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D005026:Ethylene Glycols; C545186:florbetapir
keywords: Alzheimer’s disease; Amyloid-PET; dementia; mild cognitive impairment; neuroimaging