title: Newborn blood gas derangements of children born extremely preterm and neurocognitive dysfunctions at age 10 years.
abstract: Among 740 children born extremely preterm, we evaluated the relationship between the highest and lowest quartiles of the distributions of PaO2and PaCO2, as well as the lowest quartile of pH on one day, and separately on two days, and the risk of neurocognitive, language, and behavioral dysfunctions at age 10 years. Children who had hypoxemia, hyperoxemia, hypocapnia, hypercapnia, and acidemia, sometimes on only one day, and sometimes on two or more days, were more likely than others to have a high illness severity score (within the first 12 postnatal hours), and 10 years later to have multiple dysfunctions. The tendency of blood gas derangements to be associated with high illness severity scores and with multiple dysfunctions 10 years later is compatible with the possibility that blood gas derangements are indicators of physiologic instability/vulnerability/immaturity rather than contributors to brain damage.
authors.affiliation: Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: alan.leviton@childrens.harvard.edu.
authors.forename: Alan
authors.initials: A
authors.lastname: Leviton
authors.affiliation: Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Elizabeth N
authors.initials: EN
authors.lastname: Allred
authors.affiliation: Boston University School of Medicine, Boston, MA, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Joseph
authors.affiliation: University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: T Michael
authors.initials: TM
authors.lastname: O'Shea
authors.affiliation: Boston University School of Medicine, Boston, MA, USA; Boston Medical Center, Boston, MA, USA.
authors.forename: Karl C K
authors.initials: KCK
authors.lastname: Kuban
mesh_terms: D001784:Blood Gas Analysis; D001921:Brain / Q000254:growth & development; D002245:Carbon Dioxide / Q000097:blood*; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D062071:Infant, Extremely Premature / Q000502:physiology* / Q000523:psychology; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000378:metabolism / Q000523:psychology; D007360:Intelligence; D016015:Logistic Models; D009422:Nervous System Diseases / Q000378:metabolism*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood*; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen
keywords: Blood gas analysis; Brain; Development; Infant; Newborn; Premature