title: [Pulmonary alveolar proteinosis: role of GM-CSF Antibodies].
abstract: Pulmonary alveolar proteinosis is a rare illness characterized by alterations in the normal depuration of surfactants from the alveolar space in a process dependent of the granulocyte-monocyte colony stimulating factor (GM-CSF). The most of the patients develop antibodies that neutralize this factor, avoiding the normal homeostasis of surfactants. Therapeutic options include the total lung washes and administration of GM-CSF when the washes fail. Despite the contribution related with the knowledge about of the nature of the disease, the measurement of serum antibodies anti-GM-CSF is not a routine technique. We present a systematic review of this challenging disease.
authors.affiliation: Hospital Británico de Buenos Aires, Servicio de Neumonología CABA.
authors.forename: Glenda
authors.initials: G
authors.lastname: Ernst
authors.affiliation: Hospital Británico de Buenos Aires, Clínica Médica CABA.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Salvado
authors.affiliation: Hospital María Ferrer, Servicio de Neumonología, CABA.
authors.forename: Pedro
authors.initials: P
authors.lastname: Grynblat
authors.affiliation: Hospital Cetrángolo, Servicio de Neumonología, Buenos Aires.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Tabaj
authors.affiliation: Hospital Posadas, Servicio de Neumonología y Endoscopia Respiratoria, Buenos Aires.
authors.forename: Oscar
authors.initials: O
authors.lastname: Garcia
authors.affiliation: Centro Dr. Lázaro Langer, Servicio de Neumonología, Hospital Rawson, Córdoba.
authors.forename: Victor Hugo
authors.initials: VH
authors.lastname: Cambursano
authors.affiliation: Hospital Británico de Buenos Aires, Clínica Médica CABA.
authors.forename: P
authors.initials: P
authors.lastname: Young
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology*; D006801:Humans; D011649:Pulmonary Alveolar Proteinosis / Q000276:immunology* / Q000628:therapy
chemical_list: D001323:Autoantibodies; D016178:Granulocyte-Macrophage Colony-Stimulating Factor