title: Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats.
abstract: We evaluated the effects of cinnamon polyphenol extract on hepatic transcription factors expressions including SREBP-1c and LXR-αin rats fed high fat diet (HFD). Twenty-eight Wistar rats were allocated into four groups: (i) normal control: animals fed with normal chow; (ii) cinnamon: animals supplemented with cinnamon polyphenol; (iii) HFD: animals fed a high-fat diet; and (iv) HFD + cinnamon: animals fed a high-fat diet and treated with cinnamon polyphenol. Obesity was linked to hyperglycemia, hyperlipidemia, and oxidative stress as imitated by elevated serum glucose, lipid profile, and serum and liver malondialdehyde (MDA) concentrations. Cinnamon polyphenol decreased body weight, visceral fat, liver weight and serum glucose and insulin concentrations, liver antioxidant enzymes, and lipid profile (P< 0.05) and reduced serum and liver MDA concentration compared to HFD rats (P< 0.05). Cinnamon polyphenol also suppressed the hepatic SREBP-1c, LXR-α, ACLY, FAS, and NF-κB p65 expressions and enhanced the PPAR-α, IRS-1, Nrf2, and HO-1 expressions in the HFD rat livers (P< 0.05). In conclusion, cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress through activating transcription factors and antioxidative defense signaling pathway in HFD rat liver.
authors.affiliation: Division of Biology, Faculty of Science, Firat University, Elazig, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Tuzcu
authors.affiliation: Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Orhan
authors.affiliation: Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Sahin
authors.affiliation: Research and Development, OmniActive Health Technologies Inc., Morristown, NJ, USA.
authors.forename: Vijaya
authors.initials: V
authors.lastname: Juturu
authors.affiliation: Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey.
authors.forename: Kazim
authors.identifier: 0000-0001-9542-5244
authors.initials: K
authors.lastname: Sahin
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002935:Cinnamomum zeylanicum / Q000737:chemistry* / Q000378:metabolism; D059305:Diet, High-Fat; D006949:Hyperlipidemias / Q000517:prevention & control*; D007249:Inflammation; D007328:Insulin / Q000097:blood; D050152:Intra-Abdominal Fat / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood; D018384:Oxidative Stress; D010936:Plant Extracts / Q000737:chemistry*; D059808:Polyphenols / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D059808:Polyphenols; C497389:Srebf1 protein, rat; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D008315:Malondialdehyde