title: Immunotropic aspect of the Bacillus coagulans probiotic action.
abstract: OBJECTIVE
  Currently, probiotics are increasingly used as the alternative to antibiotics as well as the preventive measures in humans. In particular, probiotics occupy a key position in the treatment of antibiotics-associated intestinal dysbiosis. A spore-forming microorganism lactobacillus Bacillus coagulans is one of the most promising probiotics. However, some of its pharmacological effects remain poorly understood. This study was aimed at investigation of the effect of B. coagulans (Laktovit Forte) on the intestinal dysbiosis syndrome in mice caused by streptomycin against the background of cyclophosphamide-induced cellular immunodeficiency.
  
  
  METHODS
  Pharmacological method: mouse model in vivo with immunodeficiency caused by cyclophosphamide.
  
  
  RESULTS
  In mice with colitis caused by streptomycin treatment, the administration of B. coagulans (Laktovit Forte medicinal product) resulted in an antidiarrhoeal effect, normalisation of gastrointestinal motility and prevention of the animals' weight loss. Given the cyclophosphamide-induced immunosuppression and streptomycin-associated diarrhoea, the immunity was completely restored only under the action of B. coagulans.
  
  
  CONCLUSIONS
  According to all parameters, B. coagulans has been proved to be more effective as compared to the Linex Forte reference product containing lacto- and bifidobacteria.
authors.affiliation: Laboratory and Clinical Department of Molecular Immunopharmacology, Mechnikov Institute of Microbiology and Immunology, Kharkov, Ukraine.
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Bomko
authors.affiliation: Laboratory and Clinical Department of Molecular Immunopharmacology, Mechnikov Institute of Microbiology and Immunology, Kharkov, Ukraine.
authors.forename: Tatiana N
authors.initials: TN
authors.lastname: Nosalskaya
authors.affiliation: Laboratory and Clinical Department of Molecular Immunopharmacology, Mechnikov Institute of Microbiology and Immunology, Kharkov, Ukraine.
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Kabluchko
authors.affiliation: Laboratory and Clinical Department of Molecular Immunopharmacology, Mechnikov Institute of Microbiology and Immunology, Kharkov, Ukraine.
authors.forename: Yury V
authors.initials: YV
authors.lastname: Lisnyak
authors.affiliation: Laboratory and Clinical Department of Molecular Immunopharmacology, Mechnikov Institute of Microbiology and Immunology, Kharkov, Ukraine.
authors.forename: Artur V
authors.identifier: http://orcid.org/0000-0003-1428-0085
authors.initials: AV
authors.lastname: Martynov
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology / Q000627:therapeutic use; D000070000:Bacillus coagulans / Q000276:immunology*; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000276:immunology; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology*; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D019936:Probiotics / Q000494:pharmacology / Q000627:therapeutic use*; D013307:Streptomycin / Q000633:toxicity
chemical_list: D000930:Antidiarrheals; D016207:Cytokines; D013307:Streptomycin
keywords: 
  Bacillus coagulans
  ; immunomodulation; probiotics