title: Pulmonary Artery Sarcoma Overexpressing Platelet-derived Growth Factor Receptor α.
abstract: Pulmonary artery sarcoma is highly malignant and easily metastasizes to the systemic organs. Both the introduction of novel diagnostic procedures and the development of new treatment modalities are required to achieve long-term survival. Several studies have shown that platelet-derived growth factor receptor α (PDGFRα) gene amplification is frequently observed in pulmonary artery sarcoma. PDGFRα is known to be involved in cell proliferation in certain malignancies. PDGFRα may become a potential biological marker in pulmonary artery sarcoma. We report a case in which a diagnosis of pulmonary artery sarcoma overexpressing PDGFRα was made using endovascular catheter biopsy following positron emission tomography with integrated computed tomography (PET/CT) scans.
authors.affiliation: Department of Respiratory Medicine, Sasebo City General Hospital, Japan.
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Takemoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Soda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitazaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Sumiyoshi
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Harada
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Dotsu
authors.forename: Daiki
authors.initials: D
authors.lastname: Ogawara
authors.forename: Susumu
authors.initials: S
authors.lastname: Fukahori
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
mesh_terms: D015415:Biomarkers; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008875:Middle Aged; D000072078:Positron Emission Tomography Computed Tomography; D011651:Pulmonary Artery / Q000473:pathology*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000096:biosynthesis*; D012509:Sarcoma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D019043:Vascular Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*
chemical_list: D015415:Biomarkers; D020796:Receptor, Platelet-Derived Growth Factor alpha