title: A role for GABAergic interneuron diversity in circuit development and plasticity of the neonatal cerebral cortex.
abstract: GABAergic interneurons are a highly heterogeneous group of cells that are critical for the mature function and development of the neocortex. In terms of the latter, much attention has focused on the well-established role of parvalbumin (PV+)-expressing, fast spiking, basket cells in determining the critical period plasticity. However recent endeavours have started to shed the light on the contribution of other interneuron subtypes to early circuit formation and plasticity. Data suggests that there are significant interactions between PV+ cells and other interneuron subtypes that regulate circuit development in rodents in the first postnatal week. Moreover, a number of these early interactions are transient which points to an important, distinct role for interneuron diversity in setting up emergent neocortical processing.
authors.affiliation: Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK. Electronic address: simon.butt@dpag.ox.ac.uk.
authors.forename: Simon Jb
authors.initials: SJ
authors.lastname: Butt
authors.affiliation: Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Stacey
authors.affiliation: Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Teramoto
authors.affiliation: Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Vagnoni
mesh_terms: D002540:Cerebral Cortex / Q000166:cytology* / Q000502:physiology; D059330:GABAergic Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D019579:Neocortex / Q000166:cytology* / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D010320:Parvalbumins / Q000378:metabolism
chemical_list: D010320:Parvalbumins