title: Primary cerebellar lymphoma with Hodgkin lymphoma-like morphology in a cat.
abstract: A 4-y-old cat exhibited neurologic signs such as wobbling, right head tilt, and intention tremor, and MRI revealed a mass in the cerebellum. The cat died 5 mo after initial presentation, and no neoplastic lesions, other than the cerebellar mass, were observed at autopsy. Histologically, large atypical cells resembling Hodgkin cells, with single large inclusion-like nucleoli, and those resembling Reed-Sternberg cells, with symmetrically arranged nuclei, had infiltrated the left side of the cerebellum and were admixed with small lymphocytes. These atypical cells were positive for feline leukemia virus (FeLV), CD20, BLA36, vimentin, p16, p53, and Pax5, and negative for CD3, CD79a, and Iba1 by immunohistochemistry. Multiplex PCR for immunoglobulin heavy-chain gene rearrangement revealed monoclonal proliferation of B-lymphocytes. We describe this feline primary cerebellar B-cell lymphoma that displayed Hodgkin lymphoma-like tumor cells with FeLV protein expression.
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yoshino
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: James K
authors.initials: JK
authors.lastname: Chambers
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: Taichi
authors.initials: T
authors.lastname: Nakamori
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: Yuko
authors.initials: Y
authors.lastname: Goto-Koshino
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nishigaki
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: Naoaki
authors.initials: N
authors.lastname: Matsuki
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
authors.affiliation: Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).|Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).|Laboratory of Veterinary Internal Medicine (Tsujimoto).|Laboratory of Veterinary Clinical Pathobiology (Matsuki).|Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D002415:Cats; D006689:Hodgkin Disease / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D005256:Leukemia Virus, Feline / Q000502:physiology*; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D008297:Male; D016539:Reed-Sternberg Cells / Q000473:pathology
keywords: Cats; Hodgkin-like lymphoma; cerebellum; feline leukemia virus