title: Antianginal Efficacy and Tolerability of Ranolazine as an Add-on Drug to Concomitant Medications Primarily Metoprolol in Chronic Stable Angina Patients: A Prospective, Open-Label Study.
abstract: OBJECTIVE
  To evaluate the efficacy and tolerability of ranolazine as an add-on drug in chronic stable angina patients and the impact of ranolazine on the quality of life in chronic stable angina patients receiving other antianginal medications.
  
  
  METHODS
  It was a prospective, open-label, hospital-based study involving 144 patients with chronic stable angina. First group received either metoprolol 12.5 or 25 mg/day or other antianginal medications; if the symptoms persist, the dose of metoprolol was increased to 50 mg/day, and to the second group, ranolazine 500 mg BD or 1 g OD was added along with metoprolol or others if the anginal attacks were not subsiding. The patients were followed up to 6 months with electrocardiography, treadmill test, and quality of life questionnaire. Adverse events were recorded at each visit during the study.
  
  
  RESULTS
  There was a statistically significant reduction in weekly anginal frequency (P< 0.001) and improvement in an exercise tolerance in both the groups, but more in the ranolazine group. Adverse events reported were mild, infrequent.
  
  
  CONCLUSIONS
  Ranolazine is could be used as an add-on drug in chronic angina patients not improved with metoprolol or antianginal medications.
authors.affiliation: Department of Pharmacology, BLDEU's Shri B. M. Patil Medical College and RC, Vijayapura, Bengaluru, Karnataka, India.
authors.forename: Anant Mahaveer
authors.initials: AM
authors.lastname: Khot
authors.affiliation: Department of Pharmacology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: H V
authors.initials: HV
authors.lastname: Anuradha
authors.affiliation: Department of Cardiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: V S
authors.initials: VS
authors.lastname: Prakash
authors.affiliation: Department of Pharmacology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India.
authors.forename: M C
authors.initials: MC
authors.lastname: Shivamurathy
keywords: Coronary artery disease; exercise tolerance; percutaneous intervention; quality of life; ranolazine