title: Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response.
abstract: Fetuin-A is a biomarker of disease activity in multiple sclerosis. Our aim was to investigate whether Fetuin-A plays a direct role in the neuroinflammatory response in the mouse EAE model. Peak Fetuin-A expression in the CNS and in peripheral lymphoid tissue correlated with peak EAE disease activity. Fetuin-A-deficient mice showed reduced EAE severity associated with an accumulation of splenic monocyte and dendritic cell populations, increased IL-12p40, ASC1, and IL-1β expression, and an increase in T regulatory cells. The upregulation of Fetuin-A in LPS-stimulated dendritic cells and microglia further supports an intrinsic role of Fetuin-A in regulating innate immune activation during EAE.
authors.affiliation: Tisch Multiple Sclerosis Research Center of New York, New York, New York, United States of America.
authors.forename: Violaine K
authors.identifier: http://orcid.org/0000-0002-3057-3059
authors.initials: VK
authors.lastname: Harris
authors.affiliation: Tisch Multiple Sclerosis Research Center of New York, New York, New York, United States of America.
authors.forename: Lena
authors.initials: L
authors.lastname: Bell
authors.affiliation: Tisch Multiple Sclerosis Research Center of New York, New York, New York, United States of America.
authors.forename: Ruth-Anne
authors.initials: RA
authors.lastname: Langan
authors.affiliation: Tisch Multiple Sclerosis Research Center of New York, New York, New York, United States of America.
authors.forename: John
authors.initials: J
authors.lastname: Tuddenham
authors.affiliation: Tisch Multiple Sclerosis Research Center of New York, New York, New York, United States of America.
authors.forename: Mark
authors.initials: M
authors.lastname: Landy
authors.affiliation: Tisch Multiple Sclerosis Research Center of New York, New York, New York, United States of America.
authors.forename: Saud A
authors.initials: SA
authors.lastname: Sadiq
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000628:therapy; D007113:Immunity, Innate; D051379:Mice; D008810:Mice, Inbred C57BL; D013116:Spinal Cord / Q000378:metabolism; D015854:Up-Regulation; D060749:alpha-2-HS-Glycoprotein / Q000172:deficiency* / Q000378:metabolism
chemical_list: D060749:alpha-2-HS-Glycoprotein