title: NK cells control breast cancer and related cancer stem cell hematological spread.
abstract: The growth and recurrence of a number of cancers is driven by a scarce population of cancer stem cells (CSCs), which are resistant to most current therapies. It has been shown previously that natural killer (NK) cells recognize human glioma, melanoma, colon and prostate CSCsin vitro. We herein show that human and mouse breast CSCs are also susceptible to NK cytotoxic activityin vitro. Moreover, CSC induced autologous NK cell activation and expansionin vivo, which correlate with the inhibition of CSC metastatic spread. These data suggest that NK cells control CSC metastatic spreadin vivoand that their use in breast cancer therapy may well be fruitful.
authors.affiliation: Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro , Catanzaro, Italy.
authors.forename: Rossana
authors.initials: R
authors.lastname: Tallerico
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin , Turin, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Conti
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin , Turin, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Lanzardo
authors.affiliation: Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy; Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet, Stockholm, Sweden.
authors.forename: Rosa
authors.initials: R
authors.lastname: Sottile
authors.affiliation: Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro , Catanzaro, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Garofalo
authors.affiliation: Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet , Stockholm, Sweden.
authors.forename: Arnika K
authors.initials: AK
authors.lastname: Wagner
authors.affiliation: Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet , Stockholm, Sweden.
authors.forename: Maria H
authors.initials: MH
authors.lastname: Johansson
authors.affiliation: Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro , Catanzaro, Italy.
authors.forename: Costanza Maria
authors.initials: CM
authors.lastname: Cristiani
authors.affiliation: Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet , Stockholm, Sweden.
authors.forename: Klas
authors.initials: K
authors.lastname: Kärre
authors.affiliation: Tumor Immunology and Immunopathology Laboratory, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy; Department of Microbiology, Cell and Tumor Biology (MTC), Karolinska Institutet, Stockholm, Sweden.
authors.forename: Ennio
authors.initials: E
authors.lastname: Carbone
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin , Turin, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Cavallo
keywords: Breast cancer; CSCs; NK cells; immunotherapy; metastasization; tumorspheres