title: Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer.
abstract: Positively charged water-soluble polythiophene (PT0) that could self-assemble into nanoparticles in pure water solution was designed and synthesized. PT0 exhibited high photostabilities and pH stabilities, excellent biocompatibility, strong1O2generation capability, and large two-photon absorption cross sections. Moreover, we showed that the fluorescence of PT0 was unaffected by the interference of biomolecules and metal ions. As an example application, PT0 was demonstrated to be capable of simultaneous cell imaging and photodynamic therapy under either one-photon or two-photon excitation modes.
authors.forename: Minhuan
authors.initials: M
authors.lastname: Lan
authors.forename: Shaojing
authors.initials: S
authors.lastname: Zhao
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS) , Beijing, China.
authors.forename: Junfang
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS) , Beijing, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Guo
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS) , Beijing, China.
authors.forename: Guangle
authors.identifier: http://orcid.org/0000-0002-5403-6880
authors.initials: G
authors.lastname: Niu
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS) , Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Hongyan
authors.initials: H
authors.lastname: Sun
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS) , Beijing, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS) , Beijing, China.
authors.forename: Weimin
authors.identifier: http://orcid.org/0000-0001-7507-6032
authors.initials: W
authors.lastname: Liu
authors.forename: Jinyuan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS) , Beijing, China.|School of Future Technology, University of Chinese Academy of Sciences , Beijing, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wang
authors.forename: Wenjun
authors.identifier: http://orcid.org/0000-0002-4497-0688
authors.initials: W
authors.lastname: Zhang
mesh_terms: D005453:Fluorescence; D006801:Humans; D009369:Neoplasms; D010778:Photochemotherapy; D017785:Photons; D017319:Photosensitizing Agents; D011108:Polymers / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry*; D014867:Water
chemical_list: D017319:Photosensitizing Agents; D011108:Polymers; D013876:Thiophenes; D014867:Water; C066730:polythiophene
keywords: PDT; conjugated polymer; fluorescence imaging; two photon