title: Differential modulation of thalamo-parietal interactions by varying depths of isoflurane anesthesia.
abstract: The thalamus is thought to relay peripheral sensory information to the somatosensory cortex in the parietal lobe. Long-range thalamo-parietal interactions play an important role in inducing the effect of anesthetic. However, whether these interaction changes vary with different levels of anesthesia is not known. In the present study, we investigated the influence of different levels of isoflurane-induced anesthesia on the functional connectivity between the thalamus and the parietal region. Microelectrodes were implanted in rats to record local field potentials (LFPs). The rats underwent different levels of isoflurane anesthesia [deep anesthesia: isoflurane (ISO) 2.5 vol%, light anesthesia (ISO 1 vol%), awake, and recovery state] and LFPs were recorded from four different brain areas (left parietal, right parietal, left thalamus, and right thalamus). Partial directed coherence (PDC) was calculated for these areas. With increasing depth of anesthesia, the PDC in the thalamus-to-parietal direction was significantly increased mainly in the high frequency ranges; however, in the parietal-to-thalamus direction, the increase was mainly in the low frequency band. For both directions, the PDC changes were prominent in the alpha frequency band. Functional interactions between the thalamus and parietal area are augmented proportionally to the anesthesia level. This relationship may pave the way for better understanding of the neural processing of sensory inputs from the periphery under different levels of anesthesia.
authors.affiliation: Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, South Korea.
authors.forename: Dongrae
authors.initials: D
authors.lastname: Cho
authors.affiliation: Department of Pediatric Dentistry and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Teo Jeon
authors.initials: TJ
authors.lastname: Shin
authors.affiliation: Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, South Korea.
authors.forename: Jinsil
authors.initials: J
authors.lastname: Ham
authors.affiliation: Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, South Korea.
authors.forename: Dong-Hyuk
authors.initials: DH
authors.lastname: Choi
authors.affiliation: Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, South Korea.
authors.forename: Seonghyun
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, South Korea.
authors.forename: Seongwook
authors.initials: S
authors.lastname: Jeong
authors.affiliation: Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, South Korea.
authors.forename: Hyoung-Ihl
authors.initials: HI
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, South Korea.
authors.forename: Jae Gwan
authors.initials: JG
authors.lastname: Kim
authors.affiliation: Department of Biomedical Science and Engineering, Institute of Integrated Technology, Gwangju Institute of Science and Technology, Gwangju, South Korea.
authors.forename: Boreom
authors.initials: B
authors.lastname: Lee
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008839:Microelectrodes; D010296:Parietal Lobe / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D013788:Thalamus / Q000187:drug effects* / Q000502:physiology
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane