title: Effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology of streptozotocin-induced diabetic mice model.
abstract: To observe effect of sophora japonica total flavonoids on pancreas, kidney tissue morphology of streptozotocin-induced diabetic mice model. Mice received tail vein injection of streptozotocin (60 mg/kg) for diabetes modeling. The model mice were divided into five groups, to be respectively fed with high, middle and small doses of sophora japonica total flavonoids solution, metformin solution and saline of the same volume. Another blank control group was set to be fed with saline of the same volume. The mice were administered once a day for 30 consecutive days, to be euthanatized after fasting blood glucose level testing on 30th day with pancreas, kidney taken out for pathological section and microscopic examination. The mice chain streptozotocin diabetes modeling was successful, with significant pathological changes (P< 0.01) in pancreas, kidney. Compared with model group, high, middle and small doses of sophora japonica total flavonoids could significantly alleviate streptozotocin-induced pancreas, kidney damage (P< 0.01).
  
  
  CONCLUSIONS
  Sophora japonica total flavonoids can effectively alleviate pancreas, kidney injury of streptozotocin-induced diabetic mice model.
authors.affiliation: College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Henan University of Chinese Medicine, Zhengzhou 450046, China.
authors.forename: Mingsan
authors.initials: M
authors.lastname: Miao
authors.affiliation: Henan University of Chinese Medicine, Zhengzhou 450046, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Bai
authors.affiliation: College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
authors.forename: Cairong
authors.initials: C
authors.lastname: Li
authors.affiliation: College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
authors.forename: Yuyin
authors.initials: Y
authors.lastname: Xu
keywords: Diabetes model; Mice; Morphology; Sophora japonica total flavonoids