title: Wip1: A candidate phosphatase for cancer diagnosis and treatment.
abstract: The critical regulatory mechanisms in numerous cellular pathways including cell survival and DNA damage response mostly depend on phosphorylation and dephosphorylation of proteins. The serine/threonine phosphatase wild-type p53-induced phosphatase 1 (Wip1) is a growth-promoting phosphatase and its numerous downstream targets are important tumor suppressors. Here, we review the Wip1 activity and its relevance to cancer as an oncoprotein. Consecutive investigations about Wip1 and its relation to cancer is critical, as these studies ultimately contribute to the etiology of cancer. A number of innovative studies have recently investigated the importance of Wip1 as a new candidate for cancer diagnosis and prognosis. Accordingly, we discuss the present challenges of using Wip1 as a target for cancer treatment.
authors.affiliation: Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
authors.forename: Tayebeh
authors.initials: T
authors.lastname: Oghabi Bakhshaiesh
authors.affiliation: Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
authors.forename: Keivan
authors.initials: K
authors.lastname: Majidzadeh-A
authors.affiliation: Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran. Electronic address: esmaeili.rezvan@gmail.com.
authors.forename: Rezvan
authors.initials: R
authors.lastname: Esmaeili
mesh_terms: D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D015513:Oncogene Proteins; D000071636:Protein Phosphatase 2C
chemical_list: D015513:Oncogene Proteins; C000607458:PPM1D protein, human; D000071636:Protein Phosphatase 2C
keywords: Cancer therapy; DNA damage response; PPM1D; Wip1; p53