title: Effect of a bradykinin-potentiating factor isolated from scorpion venom (Leiurus quinquestriatus) on some blood indices and lipid profile in irradiated rats.
abstract: Bradykinin appears to be an important regulator of cardiovascular function. It is also being increasingly noted as a participant in actions of drugs that affect the liver, kidney, and circulation. In our previous studies, bradykinin-potentiating factor (BPF) isolated from scorpion venom (Leiurus quinquestriatus) has been shown to be protective against hepato- and nephrotoxicity as well as healing skin burns by reducing oxidative stress in hyperglycemic conditions. Therefore, we aim to evaluate the ability of BPF in treating irradiated rats. A group of rats was exposed to γ-irradiation and subsequently treated with BPF injections aiming to elucidate the possibility of BPF to rescue γ-irradiation harmful effects. As controls, we used γ-irradiation exposed, BPF-injected, and untreated rats. The data obtained showed that the irradiated animals suffered from marked changes of many important blood parameters including red blood cells, leukocytes, platelets, hemoglobin, packed cell volume, high-density cholesterol, total cholesterol, triglycerides, and low-density cholesterol. Interestingly, BPF was able to rescue the deleterious effects of irradiation in rats and normalized their blood parameters to the basal levels. We conclude that BPF could ameliorate irradiation damaging effects.
authors.affiliation: Department of Zoology, Faculty of Science, South Valley University, Qena, 83523, Egypt.
authors.forename: Muhammad M A
authors.initials: MMA
authors.lastname: Salman
authors.affiliation: Institute of Anatomy and Cell Biology, University Medicine Greifswald, Friedrich-Loeffler-Str. 23c, Greifswald, 17487, Germany. kotba@uni-greifswald.de.|Department of Anatomy and Histology, Assiut University, Faculty of Veterinary Medicine, Assiut, 71515, Egypt. kotba@uni-greifswald.de.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Kotb
authors.affiliation: Department of Pathology & Clinical Pathology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt.
authors.forename: Mohie A M
authors.initials: MAM
authors.lastname: Haridy
authors.affiliation: Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund, Dortmund, 44139, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Golka
authors.affiliation: Molecular Hepatology, Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.|Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt.
authors.forename: Seddik
authors.initials: S
authors.lastname: Hammad
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001920:Bradykinin / Q000819:agonists*; D002784:Cholesterol / Q000097:blood*; D016207:Cytokines / Q000378:metabolism; D005720:Gamma Rays; D006403:Hematologic Tests; D008297:Male; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012604:Scorpion Venoms / Q000737:chemistry*; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology; D014280:Triglycerides / Q000097:blood*
chemical_list: D016207:Cytokines; D011837:Radiation-Protective Agents; D012604:Scorpion Venoms; D014280:Triglycerides; D002784:Cholesterol; D001920:Bradykinin
keywords: Antioxidant; BPF; Irradiation; Leiurus quinquestriatus; RBCs and WBCs