title: ESCRTing Necroptosis.
abstract: Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Heath San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Heath San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. Electronic address: kaiserw@uthscsa.edu.
authors.forename: William J
authors.initials: WJ
authors.lastname: Kaiser
mesh_terms: D017209:Apoptosis; D009336:Necrosis; D010766:Phosphorylation; D011494:Protein Kinases; D053422:Receptor-Interacting Protein Serine-Threonine Kinases
chemical_list: D011494:Protein Kinases; D053422:Receptor-Interacting Protein Serine-Threonine Kinases