title: Regional Overlap of Pathologies in Lewy Body Disorders.
abstract: Lewy body disorders (LBD) are common neurodegenerative diseases characterized by the presence of aggregated α-synuclein in Lewy bodies and Lewy neurites in the central and peripheral nervous systems. The brains of patients with LBD often display other comorbid pathologies, i.e. insoluble tau, β-amyloid aggregates, TAR DNA-binding protein 43 (TDP-43) deposits, and argyrophilic grain disease (AGD). The incidence and physiological relevance of these concurrent pathological findings remain controversial. We performed a semiquantitative detailed mapping of α-synuclein, tau, β-amyloid (Aβ), TDP-43, and AGD pathologies in 17 areas in 63 LBD cases (44 with Parkinson disease [PD], 28 with dementia, and 19 with dementia with Lewy bodies). APOE and MAPT genetic variants were also investigated. A majority of LBD cases had 2 or 3 concomitant findings, particularly Alzheimer disease-related pathology. Pathological stages of tau, β-amyloid and α-synuclein pathologies were increased in cases with dementia. Aβ score was the best correlate of the time to dementia in PD. In addition, β-amyloid deposition correlated with α-synuclein load in all groups. MAPT H1 haplotype did not influence any assessed pathology in PD. These results highlight the common concurrence of pathologies in patients with LBD that may have an impact on the clinical expression of the diseases.
authors.affiliation: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.|CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.
authors.forename: Martí
authors.initials: M
authors.lastname: Colom-Cadena
authors.affiliation: Neurological Tissue Bank, Biobanc Hospital Clínic-IDIBAPS, Barcelona, Spain.
authors.forename: Oriol
authors.initials: O
authors.lastname: Grau-Rivera
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Lluís
authors.initials: L
authors.lastname: Planellas
authors.affiliation: Parkinson's Disease and Movement Disorders Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.|Neurology Unit, Hospital Universitario San Ignacio, School of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia.
authors.forename: Catalina
authors.initials: C
authors.lastname: Cerquera
authors.affiliation: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.|CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.
authors.forename: Estrella
authors.initials: E
authors.lastname: Morenas
authors.affiliation: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.|CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Helgueta
authors.affiliation: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.|CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.
authors.forename: Laia
authors.initials: L
authors.lastname: Muñoz
authors.affiliation: CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.
authors.forename: Jaime
authors.initials: J
authors.lastname: Kulisevsky
authors.affiliation: CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.|Parkinson's Disease and Movement Disorders Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Martí
authors.affiliation: CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.|Neurological Tissue Bank, Biobanc Hospital Clínic-IDIBAPS, Barcelona, Spain.
authors.forename: Eduard
authors.initials: E
authors.lastname: Tolosa
authors.affiliation: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.|CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Clarimon
authors.affiliation: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.|CIBERNED, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Lleó
authors.affiliation: Neurological Tissue Bank, Biobanc Hospital Clínic-IDIBAPS, Barcelona, Spain.
authors.forename: Ellen
authors.initials: E
authors.lastname: Gelpi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D020961:Lewy Body Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D051844:alpha-Synuclein / Q000235:genetics / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D051844:alpha-Synuclein; D016875:tau Proteins
keywords: Copathology; Dementia with Lewy bodies; Parkinson disease; Parkinson disease dementia; Tau; α-Synuclein; β-Amyloid