title: Current Status of Dengue Therapeutics Research and Development.
abstract: Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue.
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital.
authors.forename: Jenny G H
authors.initials: JG
authors.lastname: Low
authors.affiliation: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School.|Department of Microbiology and Immunology, National University of Singapore.|Singapore MIT Alliance in Research and Technology Infectious Diseases Interdisciplinary Research Group.
authors.forename: Eng Eong
authors.initials: EE
authors.lastname: Ooi
authors.affiliation: Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School.|Department of Microbiology and Immunology, National University of Singapore.
authors.forename: Subhash G
authors.initials: SG
authors.lastname: Vasudevan
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003715:Dengue / Q000188:drug therapy* / Q000517:prevention & control; D055808:Drug Discovery; D006801:Humans
chemical_list: D000911:Antibodies, Monoclonal; D000998:Antiviral Agents
keywords: antivirals; dengue; dengue drug discovery; dengue prophylaxis; dengue therapeutics; flavivirus