title: Influence of molecular characteristics in the prognosis of methicillin-resistant Staphylococcus aureus prosthetic joint infections: beyond the species and the antibiogram.
abstract: We have explored the relationship of phenotypic (antibiogram, β-haemolysis, agr functionality, biofilm formation) and genotypic characteristics on the prognosis of 18 cases of methicillin-resistant S. aureus prosthetic joint infection (2005-2015). All isolates belonged to CC5, and had agr type II. This pilot study suggests that phage-borne genes belonging to the immune evasion cluster (chp, sak and scn) were more frequent among episodes with treatment failure (80.0 vs. 37.5%).
authors.affiliation: Servicio de Microbiología, Instituto de Investigación Biomédica Hospital 12 de Octubre, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Muñoz-Gallego
authors.affiliation: Unidad de Enfermedades Infecciosas, Instituto de Investigación Biomédica Hospital 12 de Octubre, Hospital Universitario 12 de Octubre, Avenida de Córdoba sn, Madrid, 28041, Spain. jaime@lora-tamayo.es.
authors.forename: Jaime
authors.initials: J
authors.lastname: Lora-Tamayo
authors.affiliation: Servicio de Microbiología, Instituto de Investigación Biomédica Hospital 12 de Octubre, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Dafne
authors.initials: D
authors.lastname: Pérez-Montarelo
authors.affiliation: Servicio de Microbiología, Instituto de Investigación Biomédica Hospital 12 de Octubre, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Brañas
authors.affiliation: Servicio de Microbiología, Instituto de Investigación Biomédica Hospital 12 de Octubre, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Viedma
authors.affiliation: Servicio de Microbiología, Instituto de Investigación Biomédica Hospital 12 de Octubre, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Chaves
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001178:Arthroplasty / Q000009:adverse effects*; D018441:Biofilms; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006461:Hemolysis; D006785:Hospitals, University; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis / Q000382:microbiology*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D012189:Retrospective Studies; D013030:Spain; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000382:microbiology*
keywords: Biofilms; Bone infections; DAIR; Joint infections; MRSA