title: Variation in Essential Oil and Bioactive Compounds of Curcuma kwangsiensis Collected from Natural Habitats.
abstract: The chemical compositions of essential oils (EOs) extracted from Curcuma kwangsiensis rhizomes collected from six natural habitats in P. R. China were evaluated using gas chromatography/mass spectrometry (GC/MS). Fifty-seven components were identified from the six EOs, and their main constituents were 8,9-dehydro-9-formyl-cycloisolongifolene (2.37 - 42.59%), germacrone (6.53 - 22.20%), and l-camphor (0.19 - 6.12%). The six EOs exhibited different DPPH radical-scavenging activities (IC50, 2.24 - 31.03 μg/ml), with the activity of most of EOs being much higher than that of Trolox C (IC50, 10.49 μg/ml) and BHT (IC50, 54.13 μg/ml). Most EOs had potent antimicrobial effects against the tested bacteria and fungus. They also exhibited cytotoxicity against B16 (IC50, 4.44 - 147.4 μg/ml) and LNCaP cells (IC50, 73.94 - 429.25 μg/ml). The EOs showed excellent anti-inflammatory action by significantly downregulating expression of pro-inflammatory cytokines, cyclooxygenase-2, and tumor necrosis factor-α. This study provides insight into the interrelation among growth location, phytoconstituents, and bioactivities, and the results indicate the potential of C. kwangsiensis as natural nutrients, medicines, and others additives.
authors.affiliation: Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
authors.forename: Lanyue
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
authors.forename: Zebin
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
authors.forename: Mincong
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
authors.forename: Penghui
authors.initials: P
authors.lastname: Li
authors.affiliation: Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: School of Chemical and Environment Engineering, Wuyi University, Jiangmen, 529020, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ, 08854, USA.
authors.forename: Xi
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Allan Conney Biotechnology Company Ltd, Foshan, 528200, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: Infinitus (China) Company Ltd, Guangzhou, 510006, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tang
authors.affiliation: Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
authors.forename: Yanxiong
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Institute of Natural Medicine & Green Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong, 510006, P. R. China.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Du
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002681:China; D030024:Curcuma / Q000737:chemistry*; D017753:Ecosystem; D016166:Free Radical Scavengers; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D020128:Inhibitory Concentration 50; D008546:Melanoma, Experimental / Q000473:pathology; D009822:Oils, Volatile / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D016166:Free Radical Scavengers; D009822:Oils, Volatile
keywords: 
  Curcuma kwangsiensis
  ; Anti-inflammatory activities; Cytotoxic activities; Essential oils; Phytoconstituents; Radical-scavenging activities