title: RNA G-Quadruplexes as Key Motifs of the Transcriptome.
abstract: G-Quadruplexes are non-canonical secondary structures that can be adopted under physiological conditions by guanine-rich DNA and RNA molecules. They have been reported to occur, and to perform multiple biological functions, in the genomes and transcriptomes of many species, including humans. This chapter focuses specifically on RNA G-quadruplexes and reviews the most recent discoveries in the field, as well as addresses the upcoming challenges researchers studying these structures face.
authors.affiliation: RNA Group/Groupe ARN, Département de Biochimie, Faculté de médecine des sciences de la santé, Pavillon de Recherche Appliquée au Cancer, Université de Sherbrooke, 3201 rue Jean-Mignault, Sherbrooke, QC, Canada, J1E 4K8.
authors.forename: Samuel
authors.initials: S
authors.lastname: Rouleau
authors.affiliation: RNA Group/Groupe ARN, Département de Biochimie, Faculté de médecine des sciences de la santé, Pavillon de Recherche Appliquée au Cancer, Université de Sherbrooke, 3201 rue Jean-Mignault, Sherbrooke, QC, Canada, J1E 4K8.
authors.forename: Rachel
authors.initials: R
authors.lastname: Jodoin
authors.affiliation: RNA Group/Groupe ARN, Département de Biochimie, Faculté de médecine des sciences de la santé, Pavillon de Recherche Appliquée au Cancer, Université de Sherbrooke, 3201 rue Jean-Mignault, Sherbrooke, QC, Canada, J1E 4K8.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Garant
authors.affiliation: RNA Group/Groupe ARN, Département de Biochimie, Faculté de médecine des sciences de la santé, Pavillon de Recherche Appliquée au Cancer, Université de Sherbrooke, 3201 rue Jean-Mignault, Sherbrooke, QC, Canada, J1E 4K8. Jean-Pierre.Perreault@USherbrooke.ca.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Perreault
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes; D016678:Genome / Q000235:genetics; D006801:Humans; D012313:RNA / Q000737:chemistry; D059467:Transcriptome / Q000235:genetics
chemical_list: D012313:RNA; D004247:DNA
keywords: Gene expression regulation; RNA G-quadruplex; RNA structure