title: Oral cancer cells sustainedly infected with Porphyromonas gingivalis exhibit resistance to Taxol and have higher metastatic potential.
abstract: Major obstacles to improving the prognosis of patients with oral squamous cell carcinoma (OSCC) are the acquisition of resistance to chemotherapeutic agents and development of metastases. Recently, inflammatory signals are suggested to be one of the most important factors in modulating chemoresistance and establishing metastatic lesions. In addition, epidemiological studies have demonstrated that periodontitis, the most common chronic inflammatory condition of the oral cavity, is closely associated with oral cancer. However, a correlation between chronic periodontitis and chemoresistance/metastasis has not been well established. Herein, we will present our study on whether sustained infection with Porphyromonas gingivalis, a major pathogen of chronic periodontitis, could modify the response of OSCC cells to chemotherapeutic agents and their metastatic capability in vivo. Tumor xenografts composed of P. gingivalis-infected OSCC cells demonstrated a higher resistance to Taxol through Notch1 activation, as compared with uninfected cells. Furthermore, P. gingivalis-infected OSCC cells formed more metastatic foci in the lung than uninfected cells.
authors.affiliation: Department of Oral Pathology & BK21 PLUS Project, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
authors.forename: Bok Hee
authors.initials: BH
authors.lastname: Woo
authors.affiliation: Department of Oral Pathology & BK21 PLUS Project, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
authors.forename: Da Jeong
authors.initials: DJ
authors.lastname: Kim
authors.affiliation: Department of Periodontology, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
authors.forename: Jeom Il
authors.initials: JI
authors.lastname: Choi
authors.affiliation: Department of Periodontology, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
authors.forename: Sung Jo
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Oral Anatomy, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Park
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Song
authors.affiliation: Department of Oral Pathology & BK21 PLUS Project, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.|Institute of Translational Dental Sciences, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Oral Pathology & BK21 PLUS Project, School of Dentistry, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.|Institute of Translational Dental Sciences, Pusan National University, Mulgeum-up, Yangsan 50612, South Korea.
authors.forename: Hae Ryoun
authors.initials: HR
authors.lastname: Park
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D016866:Bacteroidaceae Infections / Q000150:complications* / Q000378:metabolism / Q000382:microbiology*; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D019008:Drug Resistance, Neoplasm; D015870:Gene Expression; D006801:Humans; D008297:Male; D051379:Mice; D009062:Mouth Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D009362:Neoplasm Metastasis; D017239:Paclitaxel / Q000494:pharmacology*; D016966:Porphyromonas gingivalis; D051881:Receptor, Notch1 / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D051881:Receptor, Notch1; D017239:Paclitaxel
keywords: Notch1; Porphyromonas gingivalis; Taxol; metastasis; oral cancer