title: Experimental infection of dogs with highly pathogenic avian influenza virus (H5N8).
abstract: During the highly pathogenic avian influenza (HPAI) H5N8 virus outbreak in Korea, a dog in layer farm contaminated by H5N8 was reported seropositive for HPAI H5N8. To investigate the possibility of adaptation and transmission of HPAI H5N8 to dogs, we experimentally inoculated dogs with H5N8. Viral genes were weakly detected in nasal swabs and seroconversions in inoculated and contact dogs. Although the H5N8 virus did not induced severe clinical signs to dogs, the results suggest that surveillance of farm dogs should continue as a species in which the avian influenza virus may acquire infectivity to mammals through frequent contact with the virus.
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
authors.forename: Seong-Su
authors.initials: SS
authors.lastname: Yuk
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
authors.forename: Dong-Hun
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
authors.forename: Jae-Keun
authors.initials: JK
authors.lastname: Park
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
authors.forename: Erdene-Ochir
authors.initials: EO
authors.lastname: Tseren-Ochir
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Kwon
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
authors.forename: Jin-Yong
authors.initials: JY
authors.lastname: Noh
authors.affiliation: Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
authors.forename: Chang-Seon
authors.initials: CS
authors.lastname: Song
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D000071225:Influenza A Virus, H5N8 Subtype / Q000472:pathogenicity; D009976:Orthomyxoviridae Infections / Q000635:transmission / Q000662:veterinary* / Q000821:virology
chemical_list: D000914:Antibodies, Viral
keywords: animal experiment; dogs; influenza A virus H5N8 subtype; transmission; virulence