title: An Ir(iii)-catalyzed aryl C-H bond carbenoid functionalization cascade: access to 1,3-dihydroindol-2-ones.
abstract: An Ir(iii)-catalyzed relay aryl C-H bond carbenoid insertion cascade of N-aryl-2-pyridinamines with diazo Meldrum's acid has been developed. This method provides an efficient approach to multifunctionalized 1,3-dihydroindol-2-ones with a broad range of functional group tolerance. Furthermore, this protocol could be applied for the concise synthesis of bioactive hematopoietic growth factor analogues.
authors.affiliation: Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China. zengwei@scut.edu.cn.
authors.forename: Siyi
authors.initials: S
authors.lastname: Bai
authors.forename: Xun
authors.initials: X
authors.lastname: Chen
authors.forename: Xinwei
authors.initials: X
authors.lastname: Hu
authors.forename: Yuanfu
authors.initials: Y
authors.lastname: Deng
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*
chemical_list: D007211:Indoles; D007495:Iridium; D002244:Carbon; D006859:Hydrogen