title: Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis.
abstract: Sepsis is a life threatening condition mediated by systemic infection, but also triggered by hemorrhage and trauma. These are significant causes of organ injury implicated in morbidity and mortality, as well as post-sepsis complications associated with dysfunction of innate and adaptive immunity. The role of cellular bioenergetics and loss of metabolic plasticity of immune cells is increasingly emerging in the pathogenesis of sepsis. This review describes mitochondrial biology and metabolic alterations of immune cells due to sepsis, as well as indicates plausible therapeutic opportunities.
authors.affiliation: Division of Infectious Diseases, Korea University Ansan Hospital, Ansan, Korea.
authors.forename: Dae Won
authors.identifier: http://orcid.org/0000-0002-7653-686X
authors.initials: DW
authors.lastname: Park
authors.affiliation: Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. zmijewsk@uab.edu.
authors.forename: Jaroslaw W
authors.identifier: http://orcid.org/0000-0001-7314-6164
authors.initials: JW
authors.lastname: Zmijewski
keywords: Immune cell; Metabolism; Mitochondria; Multi-organ failure; Sepsis