title: Remote Preconditioning and Vascular Surgery.
abstract: Remote ischemic preconditioning (RIPC) is a theoretically attractive strategy for organ protection; and phase 2 studies in a variety of settings have yielded promising results. In this article, we review the existing clinical studies on RIPC in vascular surgery. We examine aspects of design that may potentially be optimized in future vascular surgery studies and we highlight some challenges that have emerged since the publication of the Remote Ischaemic Preconditioning for Heart Surgery (RIPHeart) trial and the Effect of Remote Ischaemic Preconditioning on Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Surgery (ERICCA) trial.
authors.affiliation: 1 Department of Vascular Surgery, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
authors.forename: Donagh A
authors.initials: DA
authors.lastname: Healy
authors.affiliation: 2 Department of Vascular Surgery, University Hospital Galway, Newcastle Road, Galway, Ireland.
authors.forename: Stewart R
authors.initials: SR
authors.lastname: Walsh
mesh_terms: D000818:Animals; D006801:Humans; D019194:Ischemic Preconditioning / Q000009:adverse effects / Q000379:methods*; D035002:Lower Extremity / Q000098:blood supply*; D009203:Myocardial Infarction / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology; D065840:Protective Factors; D012039:Regional Blood Flow; D012307:Risk Factors; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
keywords: cardioprotection; remote preconditioning; vascular surgery