title: Antidepressant-like deliverables from the sea: evidence on the efficacy of three different brown seaweeds via involvement of monoaminergic system.
abstract: Brown seaweeds exhibit several health benefits in treating and managing wide array of ailments. In this study, the antidepressant-like effect of methaolic extracts from Sargassum swartzii (SS), Stoechospermum marginatum (SM), and Nizamuddinia zanardinii (NZ) was examined in forced swimming test (FST), in rats. Oral administration of SS, SM, and NZ extract (30-60 mg/kg) exhibited antidepressant-like activity in FST by reducing immobility time as compared to control group, without inducing significant change in ambulatory behavior in open field test. In order to evaluate the involvement of monoaminergic system, rats were pretreated with the inhibitor of brain serotonin stores p-chlorophenylalanin (PCPA), dopamine (SCH23390 and sulpiride), and adrenoceptor (prazosin and propranolol) antagonists. Rats receiving treatment for 28 days were decapitated and brains were analyzed for monoamine levels. It may be concluded that the extracts of SS, SM, and NZ produces antidepressant-like activity via modulation of brain monoaminergic system in a rat model.
authors.affiliation: a Centre of Excellence in Marine Biology, University of Karachi , Karachi , Pakistan.
authors.forename: Pirzada Jamal Ahmed
authors.initials: PJA
authors.lastname: Siddiqui
authors.affiliation: a Centre of Excellence in Marine Biology, University of Karachi , Karachi , Pakistan.|b Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN) , Karachi , Pakistan.
authors.forename: Adnan
authors.initials: A
authors.lastname: Khan
authors.affiliation: a Centre of Excellence in Marine Biology, University of Karachi , Karachi , Pakistan.|e Batterje Medical College for Science & Technology , Jeddah , Saudi Arabia.
authors.forename: Nizam
authors.initials: N
authors.lastname: Uddin
authors.affiliation: c Department of Biochemistry , Federal Urdu University , Karachi , Pakistan.
authors.forename: Saima
authors.initials: S
authors.lastname: Khaliq
authors.affiliation: a Centre of Excellence in Marine Biology, University of Karachi , Karachi , Pakistan.
authors.forename: Munawwer
authors.initials: M
authors.lastname: Rasheed
authors.affiliation: c Department of Biochemistry , Federal Urdu University , Karachi , Pakistan.
authors.forename: Shazia
authors.initials: S
authors.lastname: Nawaz
authors.affiliation: b Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN) , Karachi , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanif
authors.affiliation: d International Center for Chemical and Biological Sciences, University of Karachi , Karachi , Pakistan.
authors.forename: Ahsana
authors.initials: A
authors.lastname: Dar
mesh_terms: D018674:Adrenergic Antagonists / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology; D003863:Depression / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D018492:Dopamine Antagonists / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D000432:Methanol; D000459:Phaeophyceae / Q000737:chemistry*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000235:genetics* / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000235:genetics* / Q000378:metabolism; D012624:Seaweed / Q000737:chemistry*; D012702:Serotonin Antagonists / Q000494:pharmacology; D012997:Solvents; D013469:Sulpiride / Q000494:pharmacology; D013550:Swimming
chemical_list: D018674:Adrenergic Antagonists; D000928:Antidepressive Agents; D001552:Benzazepines; D018492:Dopamine Antagonists; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; C534628:SCH 23390; D012702:Serotonin Antagonists; D012997:Solvents; D013469:Sulpiride; D011433:Propranolol; D010134:Fenclonine; D011224:Prazosin; D000432:Methanol
keywords: antidepressant activity; brown seaweeds; monoamines