title: 3'-Daidzein sulfonate sodium improves mitochondrial functions after cerebral ischemia/reperfusion injury.
abstract: 3'-Daidzein sulfonate sodium is a new synthetic water-soluble compound derived from daidzein (an active ingredient of the kudzu vine root). It has been shown to have a protective effect on cerebral ischemia/reperfusion injury in rats. We plan to study the mechanism of its protective effect. 3'-Daidzein sulfonate sodium was injected in rats after cerebral ischemia/reperfusion injury. Results showed that 3'-daidzein sulfonate sodium significantly reduced mitochondrial swelling, significantly elevated the mitochondrial membrane potential, increased mitochondrial superoxide dismutase and glutathione peroxidase activities, and decreased mitochondrial malondialdehyde levels. 3'-Daidzein sulfonate sodium improved the structural integrity of the blood-brain barrier and reduced blood-brain barrier permeability. These findings confirmed that 3'-daidzein sulfonate sodium has a protective effect on mitochondrial functions after cerebral ischemia/reperfusion injury, improves brain energy metabolism, and provides protection against blood-brain barrier damage.
authors.affiliation: Gannan Medical University, Ganzhou, Jiangxi Province, China.
authors.forename: Wa
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Gannan Medical University, Ganzhou, Jiangxi Province, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Gannan Medical University, Ganzhou, Jiangxi Province, China.
authors.forename: Jing
authors.identifier: 0000-0002-1265-1180
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Gannan Medical University, Ganzhou, Jiangxi Province, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Gannan Medical University, Ganzhou, Jiangxi Province, China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Huang
authors.affiliation: Gannan Medical University, Ganzhou, Jiangxi Province, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.affiliation: Gannan Medical University, Ganzhou, Jiangxi Province, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Lei
keywords: 3’-daidzein sulfonate sodium; anti-oxidation; bloodbrain barrier; cerebral ischemia/reperfusion injury; glutathione peroxidase; infarct volume; malondialdehyde; mitochondria; mitochondrial membrane potential; mitochondrial membrane swelling; nerve regeneration; neural regeneration; superoxide dismutase