title: One-health pathogens in the Aspergillus viridinutans complex.
abstract: Cryptic species in Aspergillus section Fumigati are increasingly recognised as pathogens in humans and animals. The A. viridinutans complex (AVC) has recently expanded to comprise 10 species, of which six are known to be pathogenic, including A. udagawae, A. felis, A. pseudofelis, A. parafelis, A. pseudoviridinutans, and A. wyomingensis. They cause locally invasive and disseminated invasive disease syndromes, including chronic pulmonary aspergillosis and invasive aspergillosis in humans, invasive fungal rhinosinusitis in cats, and disseminated invasive aspergillosis in dogs. In contrast to A. fumigatus, AVC species are characterized by higher minimum inhibitory concentrations (MICs) of antifungal drugs and the infections they cause are typically more chronic and more refractory to therapy. This review, of relevance for one-health practitioners, explores the history of the AVC as well as current phylogenetic relationships, secondary metabolite production, environmental distribution, clinical syndromes, and antifungal susceptibility patterns.
authors.affiliation: The University of Sydney, NSW 2006 Australia, Faculty of Veterinary Science, School of Life and Environmental Sciences.
authors.forename: Jessica J
authors.initials: JJ
authors.lastname: Talbot
authors.affiliation: The University of Sydney, NSW 2006 Australia, Faculty of Veterinary Science, School of Life and Environmental Sciences.
authors.forename: Vanessa R
authors.initials: VR
authors.lastname: Barrs
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D001228:Aspergillosis / Q000382:microbiology* / Q000662:veterinary*; D001230:Aspergillus / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification* / Q000472:pathogenicity*; D006801:Humans; D008826:Microbial Sensitivity Tests; D000074823:One Health
chemical_list: D000935:Antifungal Agents
keywords: Aspergillus; Aspergillus viridinutans complex; aspergillosis; cryptic species; section Fumigati