title: MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review).
abstract: Epithelial ovarian cancer is the fifth most frequent cause of cancer death in women. In spite of the advantages in early detection and treatment options, overall survival rates have improved only slightly in the last decades. Therefore, alternative therapeutic approaches need to overcome resistance and improve the patient survival and outcome. MicroRNAs are evolutionary conserved small non-coding RNAs that function as negative regulators of gene expression by inhibiting translation or inducing degradation of messenger RNAs. In cancer, microRNAs are aberrantly expressed thus representing potential prognostic biomarkers and novel therapeutic targets. The knowledge of novel and unexpected functions of microRNAs is rapidly evolving and the advance in the elucidation of potential clinical applications deserves attention. Recently, a specific set of microRNAs dubbed as metastamiRs have been shown to initiate invasion and metastasis in diverse types of cancer. We reviewed the current status of microRNAs in development and progression of ovarian cancer with a special emphasis on tumor cells invasion and metastasis. Also, we show an update of microRNA functions in oncogenic pathways and discuss the current scenario for potential applications in clinical and translational research in ovarian cancer.
authors.affiliation: Catedratico CONACYT, Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Palma Flores
authors.affiliation: Molecular Biomedicine Program and Biotechnology Network, Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Raúl
authors.initials: R
authors.lastname: García-Vázquez
authors.affiliation: Translational Medicine Laboratory, National Institute of Cancerology, Mexico City, Mexico.
authors.forename: Dolores
authors.initials: D
authors.lastname: Gallardo Rincón
authors.affiliation: Translational Medicine Laboratory, National Institute of Cancerology, Mexico City, Mexico.
authors.forename: Erika
authors.initials: E
authors.lastname: Ruiz-García
authors.affiliation: Laboratory of Translational Cancer Research and Cellular Therapy, National Medical Center 'Siglo XXI', Mexico City, Mexico.
authors.forename: Horacio
authors.initials: H
authors.lastname: Astudillo de la Vega
authors.affiliation: Molecular Biomedicine Program and Biotechnology Network, Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Laurence A
authors.initials: LA
authors.lastname: Marchat
authors.affiliation: Autonomous University of Mexico City, Genomics Sciences Program, Mexico City, Mexico.
authors.forename: Yarely M
authors.initials: YM
authors.lastname: Salinas Vera
authors.affiliation: Autonomous University of Mexico City, Genomics Sciences Program, Mexico City, Mexico.
authors.forename: César
authors.initials: C
authors.lastname: López-Camarillo
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D057170:Translational Research, Biomedical
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs