title: One-Pot Synthesis of 3-Substituted 2-Arylpyrrole in Aqueous Media via Addition-Annulation of Arylboronic Acid and Substituted Aliphatic Nitriles.
abstract: Pd(II)-catalyzed C-C coupling reactions between substituted aliphatic nitriles and arylboronic acids followed by in situ cyclodehydration have been employed for the first time to synthesize a wide variety of 3-substituted 2-aryl-1H-pyrroles in aqueous acetic acid. This one-pot synthesis is green, and it conforms to atom economy. The structures of two representative pyrroles, 3k and 5f, were confirmed by X-ray crystallographic analysis.
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India.
authors.forename: Md
authors.initials: M
authors.lastname: Yousuf
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India.
authors.forename: Susanta
authors.identifier: 0000-0002-5204-3876
authors.initials: S
authors.lastname: Adhikari