title: Salicylic acid peeling combined with vitamin C mesotherapy versus salicylic acid peeling alone in the treatment of mixed type melasma: A comparative study.
abstract: BACKGROUND
  Melasma is a distressing condition for both dermatologists and patients. We evaluated the effectiveness of salicylic acid (SA) peel and vitamin C mesotherapy in the treatment of melasma.
  
  
  METHODS
  Fifty female patients were divided into two groups. All patients were treated with 30% SA peel every two weeks for two months. In addition, after SA peeling Group A was intradermally administered 10 vitamin C on the melasma lesion at 1-cm intervals. All patients were followed up for 6 months, during which the recurrence rates were evaluated. Digital photographs of the melasma site were taken and patients' Melasma Area and Severity Index (MASI) scores were assessed. After the treatment, the patients were asked to complete the melasma quality of life questionnaire (MelasQoL) to evaluate their satisfaction with the treatment. All the adverse effects were noted.
  
  
  RESULTS
  The MelasQoL and MASI scores of patients in both groups significantly decreased after the treatment. Apart from a burning sensation, no adverse event was observed and all patients tolerated the treatment well.
  
  
  CONCLUSIONS
  SA peel combined with vitamin C mesotherapy is a safe and effective alternative for the treatment of melasma with no significant side effects and minimal downtime.
authors.affiliation: a Medical Faculty, Dermatology Department, School of Medicine , İstanbul Medipol University , Istanbul , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Balevi
authors.affiliation: a Medical Faculty, Dermatology Department, School of Medicine , İstanbul Medipol University , Istanbul , Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Ustuner
authors.affiliation: a Medical Faculty, Dermatology Department, School of Medicine , İstanbul Medipol University , Istanbul , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Özdemir
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002615:Chemexfoliation; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008548:Melanosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D057748:Mesotherapy; D008875:Middle Aged; D010781:Photography; D011446:Prospective Studies; D011788:Quality of Life; D020156:Salicylic Acid / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D000975:Antioxidants; D007641:Keratolytic Agents; D020156:Salicylic Acid; D001205:Ascorbic Acid
keywords: Melasma; mesotherapy; salicylic acid; vitamin C