title: Of Mice and Men: Species-Specific Organoid Models of Neocortical Malformation.
abstract: Cellular changes underlying malformations of human cortical development may be difficult to identify with traditional mouse models. Two recent Cell Stem Cell papers, Li et al. (2017) and Bershteyn et al. (2017), use human cerebral organoids to identify specific cellular defects in neurogenesis that may explain PTEN-related macrocephaly and Miller-Dieker lissencephaly.
authors.affiliation: Department of Physiology and Neurobiology, University of Connecticut Storrs, Storrs, CT 06269, USA.
authors.forename: Jesse J
authors.initials: JJ
authors.lastname: Dunnack
authors.affiliation: Department of Physiology and Neurobiology, University of Connecticut Storrs, Storrs, CT 06269, USA. Electronic address: joseph.loturco@uconn.edu.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: LoTurco
mesh_terms: D000818:Animals; D006801:Humans; D008297:Male; D051379:Mice; D019579:Neocortex; D055495:Neurogenesis; D009940:Organoids; D013045:Species Specificity; D013234:Stem Cells