title: Why DNA Is a More Effective Scaffold than RNA in Nucleic Acid-Based Asymmetric Catalysis-Supramolecular Control of Cooperative Effects.
abstract: Nucleic acids can form efficient hybrid catalysts for asymmetric catalysis upon binding of low-molecular-weight metal complexes. Up to now DNA has been the preferred nucleic acid component, while RNA was largely ignored. It is shown that despite RNA's successful use in ribozymes, RNA is less suited for use in hybrid catalysts for asymmetric catalysis. A common dimethyl bipyridine copper complex does not form highly active and enantioselective hybrid catalysts with RNA due to the absence of synergistic effects between the copper complex and dsRNA.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Correnstraße 40, 48149, Münster, Germany.
authors.forename: Jasmin J
authors.initials: JJ
authors.lastname: Marek
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Correnstraße 40, 48149, Münster, Germany.
authors.forename: Ulrich
authors.identifier: http://orcid.org/0000-0002-4904-6793
authors.initials: U
authors.lastname: Hennecke
mesh_terms: D001483:Base Sequence; D002384:Catalysis; D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D044367:Phase Transition; D012313:RNA / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D012313:RNA; D003300:Copper; D004247:DNA
keywords: DNA; RNA; asymmetric catalysis; bioorganic chemistry; cycloaddition