title: Autoantibodies, detection methods and panels for diagnosis of Sjögren's syndrome.
abstract: The presence of autoantibodies is one of several hallmarks of Sjögren's Syndrome, the detection of serum autoantibodies has a central role in the diagnosis and classification of Sjögren's syndrome. In this review, we will discuss autoantibodies that are helpful in the diagnosis of Sjögren's syndrome. This includes the traditional autoantibodies for disease classification (ANA, Anti-Ro/SSA, Anti-La/SSB, RF), autoantibodies identified from mouse models (Anti-SP1, Anti- PSP, Anti-CA6, and anti-alpha fodrin) and autoantibodies associated with other autoimmune disease (ACA, AMA, and Anti-CCP). We will also review the methods for the detection of autoantibodies and associated challenges for clinical results reporting. The significance of using an autoantibody panel for the diagnosis of SS will be also be reviewed.
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, China; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA. Electronic address: shenl@buffalo.edu.
authors.forename: Long
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA.
authors.forename: Lakshmanan
authors.initials: L
authors.lastname: Suresh
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D002256:Carbonic Anhydrases / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007118:Immunoassay; D007136:Immunoglobulins / Q000276:immunology; D008163:Luminescent Measurements; D051379:Mice; D008840:Microfilament Proteins / Q000276:immunology; D010456:Peptides, Cyclic / Q000276:immunology; D012217:Rheumatoid Factor / Q000276:immunology; D012471:Salivary Proteins and Peptides / Q000276:immunology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000276:immunology*; D013049:Spectrin
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D002256:Carbonic Anhydrases; D002352:Carrier Proteins; D007136:Immunoglobulins; D008840:Microfilament Proteins; D010456:Peptides, Cyclic; D012217:Rheumatoid Factor; D012471:Salivary Proteins and Peptides; D013049:Spectrin; C045623:BPIFA2 protein, human; C090698:SP1 antigen; C035356:SS-A antibodies; C035357:SS-B antibodies; C487763:cyclic citrullinated peptide; C477051:carbonic anhydrase VI
keywords: Autoantibodies; Detection methods; Sjögren's syndrome