title: A review on hyperthermia via nanoparticle-mediated therapy.
abstract: Hyperthermia treatment, generated by magnetic nanoparticles (MNPs) is promising since it is tumour-focused, minimally invasive and uniform. The most unique feature of magnetic nanoparticles is its reaction and modulation by a magnetic force basically responsible for enabling its potential as heating mediators for cancer therapy. In magnetic nanoparticle hyperthermia, a tumour is preferentially loaded with systemically administered nanoparticles with high-absorption cross-section for transduction of an extrinsic energy source to heat. To maximize the energy deposited in the tumour while limiting the exposure to healthy tissues, the heating is achieved by exposing the region of tissue containing magnetic nanoparticles to an alternating magnetic field. The magnetic nanoparticles dissipate heat from relaxation losses thereby heating localized tissue above normal physiological ranges. Besides thermal efficiency, the biocompatibility of magnetite nanoparticles assisted its deployment as efficient drug carrier for targeted therapeutic regimes. In the present article, we provide a state-of-the-art review focused on progress in nanoparticle induced hyperthermia treatments that have several potential advantages over both global and local hyperthermia treatments achieved without nanoparticles. Green bio-nanotechnology has attracted substantial attention and has demonstrable abilities to improve cancer therapy. Furthermore, we have listed the challenges associated with this treatment along with future prospective that could attract the interest of biomedical engineers, biomaterials scientists, medical researchers and pharmacological research groups.
authors.affiliation: COMSATS, institute of information technology, mathematics, 54000 Lahore, Pakistan. Electronic address: asohail@ciitlahore.edu.pk.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Sohail
authors.affiliation: COMSATS, institute of information technology, chemical engineering, Lahore, Pakistan.
authors.forename: Zaki
authors.initials: Z
authors.lastname: Ahmad
authors.affiliation: Fluid mechanics, bio-propulsion and nanosystems, aeronautical and mechanical engineering, department, university of Salford, Newton Building, UG17, M54WT Manchester, UK.
authors.forename: O Anwar
authors.initials: OA
authors.lastname: Bég
authors.affiliation: COMSATS, institute of information technology, mathematics, 54000 Lahore, Pakistan.
authors.forename: Sarmad
authors.initials: S
authors.lastname: Arshad
authors.affiliation: COMSATS, institute of information technology, chemical engineering, Lahore, Pakistan.
authors.forename: Lubna
authors.initials: L
authors.lastname: Sherin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles
keywords: Anisotropie; Anisotropy; Bionanotechnologie verte; Green bio-nanotechnology; Hyperthermia treatment; Infusion rate; Magnetic nanoparticles; Nanoparticules magnétiques; Taux d’infusion; Traitement hyperthermique