title: Ethambutol Is Cleared by a Contemporary High-Flux Hemodialyzer, and Drug Monitoring Ensures Safety and Therapeutic Effect.
abstract: It is uncertain, given the lack of recent data and the inconclusive nature of previous data, whether ethambutol is cleared by hemodialysis using contemporary dialyzers. We measured serum ethambutol concentrations before, during, and 1 h after hemodialysis in a 75-year-old Caucasian man receiving ethambutol for disseminated Bacille Calmette-Guérin infection. There was a mean 41% decrease in serum ethambutol concentration during dialysis, confirming the hemodialyzability of ethambutol and the utility of drug monitoring in ensuring safety.
authors.affiliation: Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Australia christopher.chew@doctors.org.uk marion.woods@health.qld.gov.au.|School of Medicine, University of Queensland, Brisbane, Australia.
authors.forename: Rusheng
authors.initials: R
authors.lastname: Chew
authors.affiliation: Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: Sarah
authors.initials: S
authors.lastname: Jongbloed
authors.affiliation: Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: Dev
authors.initials: D
authors.lastname: Jegatheesan
authors.affiliation: School of Medicine, University of Queensland, Brisbane, Australia.|Department of Renal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: Helen
authors.initials: H
authors.lastname: Healy
authors.affiliation: Department of Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: Kim
authors.initials: K
authors.lastname: Ta
authors.affiliation: Department of Chemical Pathology, Pathology Queensland, Brisbane, Australia.
authors.forename: Jacobus
authors.initials: J
authors.lastname: Ungerer
authors.affiliation: Department of Chemical Pathology, Pathology Queensland, Brisbane, Australia.
authors.forename: Brett
authors.initials: B
authors.lastname: McWhinney
authors.affiliation: School of Medicine, University of Queensland, Brisbane, Australia.|Department of Clinical Pharmacology, Royal Brisbane and Women's Hospital, Brisbane, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Donovan
authors.affiliation: Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Australia christopher.chew@doctors.org.uk marion.woods@health.qld.gov.au.|School of Medicine, University of Queensland, Brisbane, Australia.
authors.forename: Marion L
authors.initials: ML
authors.lastname: Woods
mesh_terms: D000368:Aged; D016903:Drug Monitoring; D004977:Ethambutol / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D006435:Renal Dialysis / Q000379:methods*
chemical_list: D004977:Ethambutol
keywords: drug monitoring; ethambutol; hemodialysis