title: Preoperative serum lipids as prognostic predictors in esophageal squamous cell carcinoma patients with esophagectomy.
abstract: This study was to evaluate the prognostic significance of serum lipids in esophageal squamous cell carcinoma patients who underwent esophagectomy. Preoperative serum lipids were collected from 214 patients who were diagnosed with esophageal squamous cell carcinoma. All of the patients received esophagectomy in Qilu Hospital of Shandong University from January 2007 to December 2008. The records and data were analyzed retrospectively. We found that low total cholesterol (for T stage, p = 0.006; for TNM stage, p = 0.039) and low-density lipoprotein cholesterol (for T stage, p = 0.031; for TNM stage, p = 0.035) were associated with advanced T stage and TNM stage. Kaplan-Meier survival analysis indicated that low total cholesterol and low-density lipoprotein cholesterol were associated with shorter disease-free survival(for total cholesterol, p = 0.045; for low-density lipoprotein cholesterol, p < 0.001) and overall survival (for total cholesterol, p = 0.043; for low-density lipoprotein cholesterol, p < 0.001). Lower low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LHR) indicated poorer disease-free survival and overall survival (both p < 0.001). In the multivariate analysis, low-density lipoprotein cholesterol and LHR were independent prognostic factors for disease-free survival and overall survival. In conclusion, our study indicated that preoperative serum total cholesterol and low-density lipoprotein cholesterol are prognostic factors for esophageal squamous cell carcinoma patients who underwent esophagectomy. LHR can serve as a promising serum lipids-based prognostic indicator.
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Pengxiang
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Qingxu
authors.initials: Q
authors.lastname: Song
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Shanghui
authors.initials: S
authors.lastname: Guan
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Bingxu
authors.initials: B
authors.lastname: Tan
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Bowen
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Wenqiao
authors.initials: W
authors.lastname: Jia
authors.affiliation: Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery*; D000077277:Esophageal Squamous Cell Carcinoma; D016629:Esophagectomy / Q000379:methods; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL
keywords: esophageal cancer; prognosis; serum lipids; squamous cell carcinoma