title: Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network based statistics analysis.
abstract: Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease characterized by a progressive cerebellar syndrome, which can be isolated or associated with extracerebellar signs. It has been shown that patients affected by SCA2 present also cognitive impairments and psychiatric symptoms. The cerebellum is known to modulate cortical activity and to contribute to distinct functional networks related to higher-level functions beyond motor control. It is therefore conceivable that one or more networks, rather than isolated regions, may be dysfunctional in cerebellar degenerative diseases and that an abnormal connectivity within specific cerebello-cortical regions might explain the widespread deficits typically observed in patients. In the present study, the network-based statistics (NBS) approach was used to assess differences in functional connectivity between specific cerebellar and cerebral "nodes" in SCA2 patients. Altered inter-nodal connectivity was found between more posterior regions in the cerebellum and regions in the cerebral cortex clearly related to cognition and emotion. Furthermore, more anterior cerebellar lobules showed altered inter-nodal connectivity with motor and somatosensory cerebral regions. The present data suggest that in SCA2 a cerebellar dysfunction affects long-distance cerebral regions and that the clinical symptoms may be specifically related with connectivity changes between motor and non-motor cerebello-cortical nodes.
authors.affiliation: Ataxia Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Olivito
authors.affiliation: Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; Clinical Imaging Science Center, Brighton and Sussex Medical School, Brighton, UK.
authors.forename: M
authors.initials: M
authors.lastname: Cercignani
authors.affiliation: Ataxia Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Lupo
authors.affiliation: Ataxia Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Psychology, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Iacobacci
authors.affiliation: Ataxia Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Psychology, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Clausi
authors.affiliation: Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), "Sapienza" University of Rome-Sant'Andrea Hospital, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Romano
authors.affiliation: SPInal REhabilitation Lab, IRCCS Fondazione Santa Lucia,Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Masciullo
authors.affiliation: Neurorehabilitation 1 and Spinal Center, Robotic Neurorehabilitation Lab, IRCCS Santa Lucia Foundation, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Molinari
authors.affiliation: Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bozzali
authors.affiliation: Ataxia Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Psychology, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Leggio
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D002531:Cerebellum / Q000000981:diagnostic imaging; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000068079:Motor Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D009415:Nerve Net / Q000000981:diagnostic imaging*; D010100:Oxygen / Q000097:blood; D012146:Rest; D012720:Severity of Illness Index; D020754:Spinocerebellar Ataxias / Q000150:complications*
chemical_list: D010100:Oxygen
keywords: Cerebellum; Cerebral cortex; Functional connectivity; Nodes; Resting-state fMRI