title: Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders.
abstract: Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an imbalance in synaptic excitation/inhibition may contribute to various aspects of ASD, including sleep impairments. Following the identification of Nlgn3R451Cmutation in patients with ASD, its effects on synaptic transmission and social behaviours have been examined extensively in the mouse model. However, the contributory role of this mutation to sleep impairments in ASD remains unknown. In this study, we showed that Nlgn3R451Cknock-in mice, an established genetic model for ASD, exhibited normal duration and distribution of sleep/wake states but significantly altered electroencephalography (EEG) power spectral profiles for wake and sleep.
authors.affiliation: Neurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, M5G 1X8, ON, Canada.|Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada.
authors.forename: Jackie J
authors.initials: JJ
authors.lastname: Liu
authors.affiliation: Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada.
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Grace
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada.|Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Horner
authors.affiliation: Neurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, M5G 1X8, ON, Canada.|Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Canada.|Division of Neurology, The Hospital of Sick Children, Toronto, Canada.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Cortez
authors.affiliation: Neurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, M5G 1X8, ON, Canada.
authors.forename: Yiwen
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Neurosciences & Mental Health Program, The Hospital for Sick Children, 555 University Ave., Toronto, M5G 1X8, ON, Canada. zhengping.jia@sickkids.ca.|Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada. zhengping.jia@sickkids.ca.
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Jia
mesh_terms: D000818:Animals; D000067877:Autism Spectrum Disorder / Q000235:genetics* / Q000503:physiopathology*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D004195:Disease Models, Animal; D004569:Electroencephalography; D004576:Electromyography; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008817:Mice, Mutant Strains; D009154:Mutation / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D012895:Sleep, REM / Q000502:physiology; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C098004:neuroligin 3
keywords: Autism; EEG; NREM; Nlgn3 R451C mouse model; REM; Sleep deficit