title: Chaunopyran A: Co-Cultivation of Marine Mollusk-Derived Fungi Activates a Rare Class of 2-Alkenyl-Tetrahydropyran.
abstract: Co-cultivation of Chaunopycnis sp. (CMB-MF028) and Trichoderma hamatum (CMB-MF030), fungal strains co-isolated from the inner tissue of an intertidal rock platform mollusc (Siphonaria sp), resulted in transcriptional activation of a rare class of 2-alkenyl-tetrahydropyran, chaunopyran A (7), and biotransformation and deactivation of the antifungal pyridoxatin (1), to methyl-pyridoxatin (8). This study illustrates the complexity of offensive and counter-offensive molecular defenses encountered during fungal co-cultivation, and the opportunities for activating new, otherwise transcriptionally silent secondary metabolites.
authors.affiliation: Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland , St Lucia, QLD 4072, Australia.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Shang
authors.affiliation: Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland , St Lucia, QLD 4072, Australia.
authors.forename: Angela A
authors.initials: AA
authors.lastname: Salim
authors.affiliation: Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland , St Lucia, QLD 4072, Australia.
authors.forename: Robert J
authors.identifier: 0000-0002-8341-7754
authors.initials: RJ
authors.lastname: Capon
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D049851:Gastropoda / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry*; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification*; D014242:Trichoderma / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D011090:Polyenes; C000621406:chaunopyran A