title: Molecularly targeted therapies in cancer: a guide for the nuclear medicine physician.
abstract: Molecular imaging continues to influence every aspect of cancer care including detection, diagnosis, staging and therapy response assessment. Recent advances in the understanding of cancer biology have prompted the introduction of new targeted therapy approaches. Precision medicine in oncology has led to rapid advances and novel approaches optimizing the use of imaging modalities in cancer care, research and development. This article focuses on the concept of targeted therapy in cancer and the challenges that exist for molecular imaging in cancer care.
authors.affiliation: Drug Development Program, Medical Oncology Princess Margaret Cancer Centre, Toronto, Canada. stephanie.lheureux@uhn.ca.
authors.forename: S
authors.initials: S
authors.lastname: Lheureux
authors.affiliation: Normandie Univ, UNICAEN, Inserm, ANTICIPE (Interdisciplinary Research for Cancers Prevention and Treatment, axis 2 BioTICLA (Biology and Innovative Therapeutics for Locally Aggressive Cancers), 14000, Caen, France.|Comprehensive Cancer Center François Baclesse, UNICANCER, 14076, Caen, France.
authors.forename: C
authors.initials: C
authors.lastname: Denoyelle
authors.affiliation: Department of Medical Biophysics, Department of Immunology, Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.
authors.forename: P S
authors.initials: PS
authors.lastname: Ohashi
authors.affiliation: Drug Development Unit, The Institute of Cancer Research & The Royal Marsden NHS Trust, Sutton, UK.
authors.forename: J S
authors.initials: JS
authors.lastname: De Bono
authors.affiliation: Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre (MUMC+), Postbox 5800, 6202, AZ, Maastricht, The Netherlands. fmottaghy@ukaachen.de.|Department of Nuclear Medicine, University Hospital, RWTH Aachen University, Pauwelsstr. 31, 52072, Aachen, Germany. fmottaghy@ukaachen.de.
authors.forename: F M
authors.initials: FM
authors.lastname: Mottaghy
mesh_terms: D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D009683:Nuclear Medicine; D010820:Physicians
keywords: cancer; imaging; pathway; targeted therapies