title: Multiorgan Involvement Confounding the Diagnosis of Bartonella henselae Infective Endocarditis in Children With Congenital Heart Disease.
abstract: Two children with congenital heart disease status post surgical correction presented with prolonged constitutional symptoms, hepatosplenomegaly and pancytopenia. Concern for malignancy prompted bone marrow biopsies that were without evidence thereof. In case 1, echocardiography identified a multilobulated vegetation on the conduit valve. In case 2, transthoracic, transesophageal and intracardiac echocardiography were performed and were without evidence of cardiac vegetations; however, pulmonic emboli raised concern for infective endocarditis. Both patients underwent surgical resection of the infected material and had histopathologic evidence of infective endocarditis. Further diagnostics identified elevated cytoplasmic antineutrophil cytoplasmic antibodies and antiproteinase 3 antibodies in addition to acute kidney injury with crescentic glomerulonephritis on renal biopsy. Serologic evidence of infection with Bartonella henselae was observed in both patients. These 2 cases highlight the potential multiorgan involvement that may confound the diagnosis of culture-negative infective endocarditis caused by B. henselae.
authors.affiliation: From the *Division of Infectious Diseases and Immunology, Department of Pediatrics, †Division of Hematology and Oncology, Department of Pediatrics, and ‡Division of Cardiology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Ouellette
authors.forename: Sarita
authors.initials: S
authors.lastname: Joshi
authors.forename: Karen
authors.initials: K
authors.lastname: Texter
authors.forename: Preeti
authors.initials: P
authors.lastname: Jaggi
mesh_terms: D000293:Adolescent; D018416:Bartonella henselae / Q000302:isolation & purification / Q000472:pathogenicity; D002372:Cat-Scratch Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006529:Hepatomegaly / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D010198:Pancytopenia / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology; D013163:Splenomegaly / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology