title: Taurine Promotes the Cartilaginous Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Vitro.
abstract: Taurine has been reported to influence osteogenic differentiation, but the role of taurine on cartilaginous differentiation using human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) remains unclear. In this study, we investigated the effect of taurine (0, 1, 5 and 10 mM) on the proliferation and chondrogenesis of hUC-MSCs by analyzing cell proliferation, accumulation of glycosaminoglycans and expression of cartilage specific mRNA. The results show though taurine did not affected the proliferation of hUC-MSCs, 5 mM of taurine is sufficient to enhanced the accumulation of glycosaminoglycans and up-regulate cartilage specific mRNA expression, namely collagen type II, aggrecan and SOX9. Taurine also inhibits chondrocyte dedifferentiation by reducing expression of collagen type I mRNA. Taken together, our study reveals that taurine promotes and maintains the chondrogenesis of hUC-MSCs.
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, No. 6, JiZhao Road, Hexi district, Tianjin, 300350, People's Republic of China.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Yao
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, No. 6, JiZhao Road, Hexi district, Tianjin, 300350, People's Republic of China. huanghuiling@126.com.
authors.forename: Huiling
authors.initials: H
authors.lastname: Huang
authors.affiliation: NewScen Coast Bio-Pharmaceutical Co., Ltd., 65 sixth Ave., TEDA, Tianjin, 300457, People's Republic of China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Li
authors.affiliation: Arthro-Anda Tianjin Biologic Technology Co., Ltd., 2F Building No. 2, Tian Bao Industrial Park, Xi Qi Road, Tianjin Airport Industrial Park, Tianjin, 300308, People's Republic of China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, No. 6, JiZhao Road, Hexi district, Tianjin, 300350, People's Republic of China.
authors.forename: Weijia
authors.initials: W
authors.lastname: Fan
authors.affiliation: Departement of Neurology, Tianjin Huanhu Hospital, No. 6, JiZhao Road, Hexi district, Tianjin, 300350, People's Republic of China.
authors.forename: Xinping
authors.initials: X
authors.lastname: Wang
authors.affiliation: Arthro-Anda Tianjin Biologic Technology Co., Ltd., 2F Building No. 2, Tian Bao Industrial Park, Xi Qi Road, Tianjin Airport Industrial Park, Tianjin, 300308, People's Republic of China.
authors.forename: Xuelian
authors.initials: X
authors.lastname: Sun
authors.affiliation: Arthro-Anda Tianjin Biologic Technology Co., Ltd., 2F Building No. 2, Tian Bao Industrial Park, Xi Qi Road, Tianjin Airport Industrial Park, Tianjin, 300308, People's Republic of China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhu
authors.affiliation: NewScen Coast Bio-Pharmaceutical Co., Ltd., 65 sixth Ave., TEDA, Tianjin, 300457, People's Republic of China.
authors.forename: Hongrui
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Arthro-Anda Tianjin Biologic Technology Co., Ltd., 2F Building No. 2, Tian Bao Industrial Park, Xi Qi Road, Tianjin Airport Industrial Park, Tianjin, 300308, People's Republic of China.
authors.forename: Huaying
authors.initials: H
authors.lastname: Wei
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D020219:Chondrogenesis / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000187:drug effects / Q000502:physiology*; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D013654:Taurine / Q000494:pharmacology*; D014470:Umbilical Cord / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*
chemical_list: D013654:Taurine
keywords: Chondrogenesis; Human mesenchymal stem cells; Taurine; Umbilical cord