title: Avian and human influenza virus compatible sialic acid receptors in little brown bats.
abstract: Influenza A viruses (IAVs) continue to threaten animal and human health globally. Bats are asymptomatic reservoirs for many zoonotic viruses. Recent reports of two novel IAVs in fruit bats and serological evidence of avian influenza virus (AIV) H9 infection in frugivorous bats raise questions about the role of bats in IAV epidemiology. IAVs bind to sialic acid (SA) receptors on host cells, and it is widely believed that hosts expressing both SA α2,3-Gal and SA α2,6-Gal receptors could facilitate genetic reassortment of avian and human IAVs. We found abundant co-expression of both avian (SA α2,3-Gal) and human (SA α2,6-Gal) type SA receptors in little brown bats (LBBs) that were compatible with avian and human IAV binding. This first ever study of IAV receptors in a bat species suggest that LBBs, a widely-distributed bat species in North America, could potentially be co-infected with avian and human IAVs, facilitating the emergence of zoonotic strains.
authors.affiliation: Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
authors.forename: Shubhada K
authors.initials: SK
authors.lastname: Chothe
authors.affiliation: Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
authors.forename: Gitanjali
authors.initials: G
authors.lastname: Bhushan
authors.affiliation: Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Nissly
authors.affiliation: Department of Physics, The Pennsylvania State University, University Park, PA, USA.
authors.forename: Yin-Ting
authors.initials: YT
authors.lastname: Yeh
authors.affiliation: Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.|Pennsylvania Game Commission, 2001 Elmerton Ave, Harrisburg, PA, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Brown
authors.affiliation: Pennsylvania Game Commission, 2001 Elmerton Ave, Harrisburg, PA, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Turner
authors.affiliation: Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
authors.forename: Jenny
authors.initials: J
authors.lastname: Fisher
authors.affiliation: Department of Biology, Temple University, Philadelphia, PA, USA.
authors.forename: Brent J
authors.initials: BJ
authors.lastname: Sewall
authors.affiliation: Department of Biology, Bucknell University, Lewisburg, PA, USA.
authors.forename: DeeAnn M
authors.initials: DM
authors.lastname: Reeder
authors.affiliation: Department of Physics, The Pennsylvania State University, University Park, PA, USA.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Terrones
authors.affiliation: Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
authors.forename: Bhushan M
authors.initials: BM
authors.lastname: Jayarao
authors.affiliation: Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA. skuchipudi@psu.edu.
authors.forename: Suresh V
authors.initials: SV
authors.lastname: Kuchipudi
mesh_terms: D000818:Animals; D002685:Chiroptera / Q000378:metabolism* / Q000821:virology*; D005455:Fluorescent Antibody Technique; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology; D053125:Influenza A Virus, H5N2 Subtype / Q000502:physiology; D009980:Influenza A virus / Q000502:physiology*; D009439:Neuraminidase / Q000378:metabolism / Q000494:pharmacology; D009976:Orthomyxoviridae Infections / Q000235:genetics / Q000378:metabolism / Q000821:virology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism*; D020545:Respiratory Mucosa / Q000378:metabolism / Q000648:ultrastructure / Q000821:virology; D053585:Virus Attachment / Q000187:drug effects
chemical_list: D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C092488:sialic acid receptor; D009439:Neuraminidase