title: Auditory processing following infantile spasms: An event-related potential study.
abstract: To investigate acoustic auditory processing in patients with recent infantile spasms (IS).
  
  
  
  Patients (n = 22; 12 female; median age 8 months; range 5-11 months) had normal preceding development, brain magnetic resonance imaging (MRI), and neurometabolic testing (West syndrome of unknown cause, uWS). Controls were healthy babies (n = 22; 11 female; median age 6 months; range 3-12 months). Event-related potentials (ERPs) and psychometry (Bayley Scales of Infant Development, Second Edition, BSID-II) took place at a month following IS remission.
  
  
  
  Following a repeated pure tone, uWS patients showed less suppression of the N100 at the mid-temporal electrodes (p = 0.006), and a prolonged response latency (p = 0.019). Their novelty P300 amplitude over the mid-temporal electrodes was halved (p = 0.001). The peak of the novelty P300 to environmental broadband sounds emerged later over the left temporal lobe in patients (p = 0.015), the lag correlating with duration of spasms (r = 0.547, p = 0.015). BSID-II scores were lower in patients (p < 0.001), with no correlation to ERP.
  
  
  
  Complex acoustic information is processed poorly following IS. This would impair language. Treatment did not reverse this phenomenon, but may have limited its severity. The data are most consistent with altered connectivity of the cortical acoustic processing areas induced by IS.
authors.affiliation: Young Epilepsy, Surrey, United Kingdom.|Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.|Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom.
authors.forename: Tangunu
authors.initials: T
authors.lastname: Fosi
authors.affiliation: Young Epilepsy, Surrey, United Kingdom.|Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom.
authors.forename: Klaus
authors.initials: K
authors.lastname: Werner
authors.affiliation: Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.|Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom.
authors.forename: Stewart G
authors.initials: SG
authors.lastname: Boyd
authors.affiliation: Centre for Developmental Cognitive Neurosciences, UCL Institute of Child Health, London, United Kingdom.
authors.forename: Michelle
authors.initials: M
authors.lastname: De Haan
authors.affiliation: Young Epilepsy, Surrey, United Kingdom.|Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.|Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom.|Department of Neurological Sciences, University of Vermont, Burlington, Vermont, U.S.A.
authors.forename: Rod C
authors.initials: RC
authors.lastname: Scott
authors.affiliation: Young Epilepsy, Surrey, United Kingdom.|Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.|Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom.
authors.forename: Brian G
authors.initials: BG
authors.lastname: Neville
mesh_terms: D000161:Acoustic Stimulation; D001306:Auditory Pathways / Q000187:drug effects / Q000503:physiopathology; D001307:Auditory Perception / Q000187:drug effects / Q000502:physiology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D003430:Cross-Sectional Studies; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D011446:Prospective Studies; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013036:Spasms, Infantile / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D013702:Temporal Lobe / Q000187:drug effects / Q000502:physiology; D014741:Video Recording; D020888:Vigabatrin / Q000627:therapeutic use
chemical_list: D011239:Prednisolone; D020888:Vigabatrin
keywords: Auditory event-related potential; Infantile spasms; N100; Novelty P300; West syndrome