title: Tf2NH-catalyzed formal [3 + 2] cycloaddition of oxadiazolones with ynamides: a simple access to aminoimidazoles.
abstract: Oxadiazolones are first employed as the three-atom coupling partners in the Tf2NH-catalyzed cycloaddition with ynamides. This formal [3 + 2] cycloaddition allows a rapid synthesis of aminoimidazoles with a broad substrate scope. The approach also features a metal-free catalytic cycloaddition process, which may find applications in the synthesis of bioactive molecules. Besides, the resulting N-methyl products can further be readily converted to free N-H aminoimidazoles.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China. xcli@dicp.ac.cn bswan@dicp.ac.cn.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yancheng
authors.initials: Y
authors.lastname: Hu
authors.forename: Xincheng
authors.initials: X
authors.lastname: Li
authors.forename: Boshun
authors.initials: B
authors.lastname: Wan