title: Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco.
abstract: Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Hsin-Yi
authors.identifier: 0000-0001-7666-2420
authors.initials: HY
authors.lastname: Hung
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University ; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
authors.forename: Wen-Ke
authors.initials: WK
authors.lastname: Du
authors.affiliation: Graduate Institute of Natural Products, College of Medicine, Chang Gung University ; Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
authors.forename: Hsiang-Chih
authors.initials: HC
authors.lastname: Ku
authors.affiliation: Department of Surgery and Anesthesiology, and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School , Tainan 701, Taiwan.
authors.forename: E-Jian
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Department of Surgery and Anesthesiology, and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School , Tainan 701, Taiwan.
authors.forename: Shih-Huang
authors.initials: SH
authors.lastname: Tai
authors.affiliation: Department of Pharmacy, College of Pharmacy and Health Care, Tajen University , Pingtung 907, Taiwan.
authors.forename: Fu-An
authors.initials: FA
authors.lastname: Chen
authors.affiliation: School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.|Department of Pharmacy, College of Pharmacy and Health Care, Tajen University , Pingtung 907, Taiwan.
authors.forename: Tian-Shung
authors.identifier: 0000-0002-2117-0266
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D012116:Resins, Plant / Q000737:chemistry*; D013481:Superoxides / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D047188:Chalcones; D005419:Flavonoids; D012116:Resins, Plant; D013481:Superoxides; C404987:flavan-3-ol; D010196:Pancreatic Elastase