title: Antibiotic-Loaded MoS2Nanosheets to Combat Bacterial Resistance via Biofilms Inhibition.
abstract: The emergence of antibiotic resistance has resulted in an increasing difficulty treating clinical infections associated with biofilms formation, one of the key processes contributed to enhance antibiotic resistance in return. With the rapid development of nanotechnology, a new way to overcome antibiotic resistance was opened up. Based on multiple properties especially antibacterial potential of MoS2nanosheets that have aroused wide attention, herein, a novel antimicrobial agent to combat resistant gram-positiveStaphylococcus aureus (S. aureus)and gram-negativeSalmonellawas prepared using chitosan functionalized MoS2nanosheets loading tetracycline hydrochloride drugs (abbreviated to CM-TH). The antibacterial and anti-biofilm activities of CM-TH nanocomposites expressed a synergy effect that the combination of nanomaterials and antibiotics were more efficient than both alone did. Particularly, the MIC values were generally decreased by a factor of dozens, suggesting CM-TH may become a possible alternative to traditional antibiotics in disrupting the biofilms and further to overcome antibiotic resistance in treating medical diseases.
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Wentao
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Liu
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Lunjie
authors.initials: L
authors.lastname: Huang
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Baowei
authors.initials: B
authors.lastname: Yang
authors.affiliation: College of Food Science and Engineering,Northwest A&F University, Yangling, Shaanxi,CHINA.
authors.forename: Daohong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Northwest A&F University, Yangling,CHINA.
authors.forename: Jianlong
authors.initials: J
authors.lastname: Wang
keywords: Antibiotic resistance; Biofilm; MoS&lt;sub&gt;2&lt;/sub&gt;; Nanocomposites