title: Impact of Respiratory Virus Infections in Exacerbation of Acute and Chronic Rhinosinusitis.
abstract: Rhinosinusitis (RS) is a symptomatic disease classification of many causes and is a major economic burden worldwide. It is widely accepted that RS is further classified into acute (ARS) and chronic (CRS) rhinosinusitis based on the duration of the symptoms, and that viral infection plays a large role in initiating or potentiating the disease. In this review, we examine the role of respiratory virus infection in the exacerbation of ARS and CRS. We explore the epidemiology of viral exacerbation of ARS and CRS and highlight key viruses that may cause exacerbation. We also review the current understanding of viral infections in the upper airway to further explain the putative underlying mechanisms of inflammatory events in ARS and CRS exacerbation. Advances in accurate diagnosis of the etiologic respiratory viruses of ARS and CRS symptoms which can lead to better disease management are also surveyed. In addition to the current treatments which provide symptomatic relief, we also explore the potential of harnessing existing antiviral strategies to prevent ARS and CRS exacerbation, especially with improved viral diagnostic tools to guide accurate prescription of antivirals against causative respiratory viruses.
authors.affiliation: Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore.
authors.forename: Kai Sen
authors.initials: KS
authors.lastname: Tan
authors.affiliation: Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore.
authors.forename: Hsiao Hui
authors.initials: HH
authors.lastname: Ong
authors.affiliation: Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
authors.forename: Vincent T K
authors.initials: VTK
authors.lastname: Chow
authors.affiliation: Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore, 119228, Singapore. entwdy@nus.edu.sg.
authors.forename: De-Yun
authors.initials: DY
authors.lastname: Wang
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D002908:Chronic Disease; D019468:Disease Management; D006801:Humans; D012141:Respiratory Tract Infections / Q000150:complications*; D012220:Rhinitis / Q000188:drug therapy / Q000821:virology*; D012852:Sinusitis / Q000188:drug therapy / Q000821:virology*; D014777:Virus Diseases / Q000150:complications* / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents
keywords: Acute rhinosinusitis; Antivirals; Bacterial infection; Chronic rhinosinusitis; Diagnosis; Exacerbation; Treatment; Viral infection