title: Asian-variant intravascular large B-cell lymphoma.
abstract: Intravascular large B-cell lymphoma (IVLBCL) is a rare and deadly malignancy involving the growth of lymphoma cells within vessel lumina of all organ types. IVLBCL is further divided into the hemophagocytic Asian variant and a classical Western variant. Both variants are difficult to diagnose by imaging, and although diagnostic criteria have been developed to guide workup, histopathological examination remains imperative. Treatment of IVLBCL remains difficult given the high mortality of the disease, but rituximab has emerged as a promising therapeutic option when combined with various cytotoxic regimens. The two main variants of IVLBCL generally manifest in their respective Asian or Western populations, and crossover between ethnicities is rare. We present the second described case of Asian-variant IVLBCL in an African American individual.
authors.affiliation: Jane Anne Nohl Division of Hematology (Su, Mohrbacher) and the Hematopathology Section, Department of Pathology (Pasch, Costales), Norris Comprehensive Cancer Center and Hospital, University of Southern California, Los Angeles, California.
authors.forename: Derrick W
authors.initials: DW
authors.lastname: Su
authors.affiliation: Jane Anne Nohl Division of Hematology (Su, Mohrbacher) and the Hematopathology Section, Department of Pathology (Pasch, Costales), Norris Comprehensive Cancer Center and Hospital, University of Southern California, Los Angeles, California.
authors.forename: Whitney
authors.initials: W
authors.lastname: Pasch
authors.affiliation: Jane Anne Nohl Division of Hematology (Su, Mohrbacher) and the Hematopathology Section, Department of Pathology (Pasch, Costales), Norris Comprehensive Cancer Center and Hospital, University of Southern California, Los Angeles, California.
authors.forename: Cristina
authors.initials: C
authors.lastname: Costales
authors.affiliation: Jane Anne Nohl Division of Hematology (Su, Mohrbacher) and the Hematopathology Section, Department of Pathology (Pasch, Costales), Norris Comprehensive Cancer Center and Hospital, University of Southern California, Los Angeles, California.
authors.forename: Imran
authors.initials: I
authors.lastname: Siddiqi
authors.affiliation: Jane Anne Nohl Division of Hematology (Su, Mohrbacher) and the Hematopathology Section, Department of Pathology (Pasch, Costales), Norris Comprehensive Cancer Center and Hospital, University of Southern California, Los Angeles, California.
authors.forename: Ann
authors.initials: A
authors.lastname: Mohrbacher