title: Burden of Infantile Hemangioma on Family: An International Observational Cross-Sectional Study.
abstract: OBJECTIVE
  Infantile hemangioma (IH) is the most frequent benign tumor of infancy resulting from vascular proliferation. Data regarding the burden on families of children with IHs are limited. This study aimed to characterize IHs and provide a comprehensive evaluation of the burden of IHs on parents of children requiring systemic treatment in the United States and Europe.
  
  
  METHODS
  This noninterventional cross-sectional study included infants with newly diagnosed IH requiring systemic treatment. A parent or family member completed two questionnaires (Family Member questionnaire; Hemangioma Family Burden [HFB] questionnaire).
  
  
  RESULTS
  A total of 693 individuals were evaluable in five countries. IHs were observed in more girls than boys (66%-83% female) and the mean age at inclusion was 0.44 to 1.4 years. Approximately half of patients had superficial IHs, approximately 70% of cases affected the head, and approximately 80% of cases were moderate or severe. Most patients received propranolol treatment. Their child's IH affected more than 70% of parents in each country, but fewer than 10% were offered psychological support. Approximately half of all parents reported that their child's IH affected their professional life. The global HFB score was significantly (p < 0.001) greater with greater IH severity. More than 90% of parents in each country were satisfied with the care of their child's disease.
  
  
  CONCLUSIONS
  This international study using the validated HFB questionnaire provides further insight into the burden of IH and highlights potential areas for future focus in assisting families with affected children.
authors.affiliation: Pierre Fabre Pharmaceuticals, Parsippany, New Jersey.
authors.forename: Christine
authors.initials: C
authors.lastname: Cazeau
authors.affiliation: North Shore LIJ Healthcare System, New York, New York.
authors.forename: Francine
authors.initials: F
authors.lastname: Blei
authors.affiliation: Hospital Universitario Cruces, Vizcaya, Spain.
authors.forename: María Del Rosario Fátima
authors.initials: MDRF
authors.lastname: Gonzáles Hermosa
authors.affiliation: Policlinico Ospedale Maggiore, Milano, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Cavalli
authors.affiliation: Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: Olivia
authors.initials: O
authors.lastname: Boccara
authors.affiliation: Klinik für Dermatologie, Kiel, Germany.
authors.forename: Regina
authors.initials: R
authors.lastname: Fölster-Holst
authors.affiliation: Pierre Fabre, Boulogne-Billancourt, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Berdeaux
authors.affiliation: Pierre Fabre Dermatologie, Lavaur, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Delarue
authors.affiliation: Pierre Fabre Dermatologie, Lavaur, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Voisard
mesh_terms: D017281:Cost of Illness; D003430:Cross-Sectional Studies; D005060:Europe; D005260:Female; D006391:Hemangioma / Q000523:psychology / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D010290:Parents / Q000523:psychology*; D011795:Surveys and Questionnaires; D014481:United States