title: Volatile Components of the Essential Oil of Artemisia montana and Their Sedative Effects.
abstract: The sedative effects of volatile components in the essential oil of Artemisia montana ("Yomogi") were investigated and measured using gas chromatography-mass spectrometry (GC-MS). Major components identified included 1,8-cineol, camphor, borneol, α-piperitone, and caryophyllene oxide. Among them, 1,8-cineol exhibited the highest flavor dilution (FD) value in an aroma extract dilution analysis (AEDA), followed by borneol, o-cymene, β-thujone, and bornyl acetate. The sedative effects of yomogi oil aroma were evaluated by sensory testing, analysis of salivary α-amylase activity, and measurement of relative fluctuation of oxygenated hemoglobin concentration in the brain using near-infrared spectroscopy (NIRS). All results indicated the stress-reducing effects of the essential oil following nasal exposure, and according to the NIRS analysis, 1,8-cineol is likely responsible for the sedative effects of yomogi oil.
authors.affiliation: Department of Food and Cosmetic Science, Tokyo University of Agriculture.|ALBION co. ltd.
authors.forename: Kento
authors.initials: K
authors.lastname: Kunihiro
authors.affiliation: Department of Food and Cosmetic Science, Tokyo University of Agriculture.
authors.forename: Takao
authors.initials: T
authors.lastname: Myoda
authors.affiliation: ALBION co. ltd.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tajima
authors.affiliation: Department of Food and Cosmetic Science, Tokyo University of Agriculture.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Gotoh
authors.affiliation: Department of Food and Cosmetic Science, Tokyo University of Agriculture.
authors.forename: Tai
authors.initials: T
authors.lastname: Kaneshima
authors.affiliation: ALBION co. ltd.
authors.forename: Takao
authors.initials: T
authors.lastname: Someya
authors.affiliation: Department of Food and Cosmetic Science, Tokyo University of Agriculture.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Toeda
authors.affiliation: Department of Food and Cosmetic Science, Tokyo University of Agriculture.
authors.forename: Takane
authors.initials: T
authors.lastname: Fujimori
authors.affiliation: Department of Food and Cosmetic Science, Tokyo University of Agriculture.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishizawa
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000818:Animals; D019341:Aromatherapy; D001156:Artemia / Q000737:chemistry*; D001921:Brain / Q000378:metabolism; D003511:Cyclohexanols / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000077591:Eucalyptol; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006993:Hypnotics and Sedatives / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D039821:Monoterpenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D009822:Oils, Volatile / Q000737:chemistry*; D008517:Phytotherapy; D010938:Plant Oils / Q000737:chemistry*; D012463:Saliva / Q000201:enzymology; D019265:Spectroscopy, Near-Infrared; D013315:Stress, Psychological / Q000517:prevention & control*; D014835:Volatilization; D055815:Young Adult; D000516:alpha-Amylases / Q000378:metabolism
chemical_list: D003511:Cyclohexanols; D006454:Hemoglobins; D006993:Hypnotics and Sedatives; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; D000516:alpha-Amylases; D000077591:Eucalyptol
keywords: Artemisia. montana; essential oil; sedative effect; volatile components