title: Modeling therapeutic response to radioiodine in metastatic thyroid cancer: a proof-of-concept study for individualized medicine.
abstract: OBJECTIVE
  Radioiodine therapy (RAI) has traditionally been used as treatment for metastatic thyroid cancer, based on its ability to concentrate iodine. Propositions to maximize tumor response with minimizing toxicity, must recognize the infinite possibilities of empirical tests. Therefore, an approach of this study was to build a mathematical model describing tumor growth with the kinetics of thyroglobulin (Tg) concentrations over time, following RAI for metastatic thyroid cancer.
  
  
  METHODS
  Data from 50 patients with metastatic papillary thyroid carcinoma treated within eight French institutions, followed over 3 years after initial RAI treatments, were included in the model. A semi-mechanistic mathematical model that describes the tumor growth under RAI treatment was designed.
  
  
  RESULTS
  Our model was able to separate patients who responded to RAI from those who did not, concordant with the physicians' determination of therapeutic response. The estimated tumor doubling-time (Td was found to be the most informative parameter for the distinction between responders and non-responders. The model was also able to reclassify particular patients in early treatment stages.
  
  
  CONCLUSIONS
  The results of the model present classification criteria that could indicate whether patients will respond or not to RAI treatment, and provide the opportunity to perform personalized management plans.
authors.affiliation: SMARTc Pharmacokinetics Unit, Aix-Marseille Université, Inserm S911 CRO2, Marseille, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Barbolosi
authors.affiliation: SMARTc Pharmacokinetics Unit, Aix-Marseille Université, Inserm S911 CRO2, Marseille, France.
authors.forename: Ilyssa
authors.initials: I
authors.lastname: Summer
authors.affiliation: SMARTc Pharmacokinetics Unit, Aix-Marseille Université, Inserm S911 CRO2, Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Meille
authors.affiliation: SMARTc Pharmacokinetics Unit, Aix-Marseille Université, Inserm S911 CRO2, Marseille, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Serre
authors.affiliation: Service de Médecine Nucléaire, Centre Jean Perrin, 63011 Clermont-Ferrand Cedex 01, France.
authors.forename: Antony
authors.initials: A
authors.lastname: Kelly
authors.affiliation: Oncopole, 31059 Toulouse Cedex 9, France.
authors.forename: Slimane
authors.initials: S
authors.lastname: Zerdoud
authors.affiliation: Hospices Civils de Lyon, Groupement Hospitalier Est, Service de Médecine Nucléaire, 69 677 Bron Cedex, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Bournaud
authors.affiliation: CLCC Institut Jean Godinot, 51056 REIMS CEDEX, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Schvartz
authors.affiliation: Service de Médecine Nucléaire, Centre Georges François Leclerc, 21079 Dijon Cedex, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Toubeau
authors.affiliation: Service de Médecine Nucléaire, Hôpital Saint-Louis APHP, 75475 Paris Cedex 10, France.
authors.forename: Marie-Elisabeth
authors.initials: ME
authors.lastname: Toubert
authors.affiliation: Service de Médecine Nucléaire, Hôpital Saint Antoine, APHP, 75012 Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Keller
authors.affiliation: Service de Médecine Nucléaire, CHU La Timone, Aix-Marseille Université, 13385 Marseille 05, France.
authors.forename: David
authors.initials: D
authors.lastname: Taïeb
mesh_terms: D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000532:radiotherapy* / Q000556:secondary; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D057285:Precision Medicine; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes
keywords: mathematical model; metastatic thyroid cancer; personalized medicine; radioactive iodine therapy; therapeutic nuclear medicine