title: Determinant roles of gender and age on SII, PLR, NLR, LMR and MLR and their reference intervals defining in Henan, China: A posteriori and big-data-based.
abstract: OBJECTIVE
  By now, there are few data of the reference intervals (RIs) of SII, PLR, NLR, LMR and MLR. We aimed to establish RIs of SII, PLR, NLR, LMR and MLR for healthy persons.
  
  
  METHODS
  A retrospective analysis on a cohort of ostensibly healthy, aged no <18 years old physical examinees who took health examination from January to December in 2013 was conducted to explore influences of age and gender on SII, PLR, NLR, LMR and MLR and to establish their RIs. And another cohort of 450 persons in our hospital from January to July in 2016 is included for validations of RIs.
  
  
  RESULTS
  NLR, LMR and MLR were significantly different between gender groups (P=.010; P<.001; P<.001, separately), while SII and PLR were not (P=.137; P=.267, separately). While SII was not changed much between age groups (P=.842), PLR, NLR, LMR and MLR were significantly different (all with P<.001). RIs of SII, PLR, NLR, LMR and MLR were: SII: [161,701]; PLR: 18-65 year-old: [61,179]/>65 year-old: [55,179]; NLR: 18-65 year-old male: [0.90,2.94]/18-65 year-old female: [0.85,3.06]/>65 year-old male: [0.95,3.57]/aged >65 year-old female: [0.83,3.30]; LMR: 18-65 year-old male: [2.50,7.50]/18-65 year-old female: [2.75,8.50]/>65 year-old male: [2.16,7.41]/>65 year-old female: [2.40,8.33]; MLR: 18-65 year-old male: [0.12,0.35]/18-65 year-old female: [0.10,0.32]/>65 year-old male: [0.12,0.41]/>65 year-old male: [0.11,0.33].
  
  
  CONCLUSIONS
  RIs of SII, PLR, NLR, LMR and MLR of people in central China were established and validated. It will benefit experimental design of the related studies and lead to better standardizations of SII, PLR, NLR, LMR and MLR for their clinical applications.
authors.affiliation: Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, Henan, China.
authors.forename: Xianchun
authors.identifier: http://orcid.org/0000-0002-8985-6547
authors.initials: X
authors.lastname: Meng
authors.affiliation: Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, Henan, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chang
authors.affiliation: Physical Examination Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Clinical Laboratory, People's Hospital of Jiangyou, Mianyang, Sichuan, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, Henan, China.
authors.forename: Gaohui
authors.initials: G
authors.lastname: Wei
authors.affiliation: Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, Henan, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, Henan, China.
authors.forename: Peiguo
authors.initials: P
authors.lastname: Zheng
authors.affiliation: Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, Henan, China.
authors.forename: Fucheng
authors.initials: F
authors.lastname: He
authors.affiliation: Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, Henan, China.
authors.forename: Wanhai
authors.initials: W
authors.lastname: Wang
authors.affiliation: Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, Henan, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ming
mesh_terms: D000328:Adult; D000367:Age Factors; D001772:Blood Cell Count / Q000592:standards* / Q000706:statistics & numerical data*; D001792:Blood Platelets / Q000166:cytology*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012737:Sex Factors
keywords: reference interval; the lymphocyte-to-monocyte ratio; the monocyte-to-lymphocyte ratio; the neutrophil-to-lymphocyte ratio; the platelet-to-lymphocyte ratio; the systemic immune-inflammation index