title: Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes.
abstract: Unchecked inflammation, impaired keratinocyte differentiation, and heightened host defense responses typify psoriasis. Lambert et al. make clever use of psoriasis patient genetics and whole transcriptome RNA-Seq analysis to implicate Act1 in these seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting differentiation and limiting innate immune responses in human keratinocytes.
authors.affiliation: Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
authors.forename: Ryan P
authors.initials: RP
authors.lastname: Hobbs
authors.affiliation: Discovery and Preclinical Development, Dermatology Therapy Area Unit, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
authors.forename: Susan H
authors.initials: SH
authors.lastname: Smith
authors.affiliation: Discovery and Preclinical Development, Dermatology Therapy Area Unit, GlaxoSmithKline, Collegeville, Pennsylvania, USA. Electronic address: spiro.x.getsios@gsk.com.
authors.forename: Spiro
authors.initials: S
authors.lastname: Getsios
mesh_terms: D002454:Cell Differentiation; D018031:Connexin 43 / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D010446:Peptide Fragments / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011565:Psoriasis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: C541130:ACT1 protein; D018031:Connexin 43; D010446:Peptide Fragments