title: Enantioselective Palladium(II)-Catalyzed Intramolecular Aminoarylation of Alkenes by Dual N-H and Aryl C-H Bond Cleavage.
abstract: An asymmetric palladium-catalyzed intramolecular oxidative aminoarylation of alkenes has been developed with quinoline-oxazoline chiral ligands and Ag2CO3as the oxidant. Various indolines containing a quaternary stereogenic center were synthesized in high yield with excellent enantioselectivity. Preliminary mechanistic studies suggest that the addition of a catalytic amount of phenylglyoxylic acid significantly accelerates the reaction and slightly enhances the enantioselectivity.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.|Key Laboratory of Functional Small Organic Molecules, Ministry of Education, Jiangxi Normal University, 99 Ziyang Road, Nanchang, Jiangxi, 330022, China.
authors.forename: Pinhong
authors.initials: P
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Liu
keywords: alkenes; aminoarylation; asymmetric catalysis; heterocycles; palladium