title: Prevalence of congenital malaria in newborns of mothers co-infected with HIV and malaria in Benin city.
abstract: BACKGROUND
  HIV and Plasmodium falciparum malaria co-infection annually complicates about one million pregnancies in sub-Saharan Africa. Congenital malaria (CM) has deleterious effects on newborns. Little is known about the effect of co-infections on the prevalence of CM in infants born by these women. This study was carried out to determine the prevalence of CM in newborns of mothers co-infected with HIV and malaria compared to HIV-negative mothers with malaria in Benin-City.
  
  
  METHODS
  Subjects were 162 newborns of mothers co-infected with HIV and malaria. Controls were 162 newborns of HIV negative malaria infected mothers. Blood film for malaria parasites was done on cord blood and peripheral blood on days 1, 3 and 7 in the newborns. Maternal peripheral blood film for malaria parasite was done at delivery and placental tissue was obtained for confirmation of placental malaria by histology. Diagnosis of malaria in blood films was by light microscopy.
  
  
  RESULTS
  The prevalence of CM in subjects was significantly higher than in controls (34.6% and 22.2%, p=.014). Profound immunodepression (maternal CD4 cell count <200 cell/mm3) was significantly associated with CM (p=.006). The major predictors of CM in subjects were maternal CD4 cell count <200 cell/mm3and placental malaria while in controls placental malaria was the only predictor.
  
  
  CONCLUSIONS
  Babies born to mothers co-infected with HIV and malaria are at increased risk for CM. All babies born by HIV positive mothers should be screened for CM.
authors.affiliation: a Department of Child Health , University of Benin Teaching Hospital , Benin-City , Nigeria.
authors.forename: Fidelis Ewenitie
authors.initials: FE
authors.lastname: Eki-Udoko
authors.affiliation: a Department of Child Health , University of Benin Teaching Hospital , Benin-City , Nigeria.
authors.forename: Ayebo E
authors.initials: AE
authors.lastname: Sadoh
authors.affiliation: a Department of Child Health , University of Benin Teaching Hospital , Benin-City , Nigeria.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Ibadin
authors.affiliation: a Department of Child Health , University of Benin Teaching Hospital , Benin-City , Nigeria.
authors.forename: Augustine I
authors.initials: AI
authors.lastname: Omoigberale
mesh_terms: D000328:Adult; D060085:Coinfection / Q000150:complications / Q000151:congenital / Q000453:epidemiology / Q000469:parasitology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000469:parasitology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology / Q000469:parasitology; D016778:Malaria, Falciparum / Q000150:complications / Q000151:congenital / Q000453:epidemiology / Q000469:parasitology; D008297:Male; D059208:Parasite Load; D018512:Parasitemia; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
keywords: Benin-City; HIV; HIV/malaria co-infected mothers; Nigeria; Plasmodium falciparum; congenital malaria