title: Metal-Free Cascade Approach toward Polysubstituted Indolizines from Chromone-Based Michael Acceptors.
abstract: An efficient cascade transformation toward indolizine-based molecules has been developed. This process leads to the rapid construction of two C-N bonds and one C-C bond without the need of any metal catalysis. The approach involves easily accessible chromone-based Michael acceptors and propargylamine derivatives as starting materials. This cascade constitutes a novel and very competitive alternative to the well reported strategies using pyridine or pyrrole derivatives for accessing the indolizine ring with substituents at uncommon C-positions.
authors.affiliation: UNILEHAVRE, FR 3038 CNRS, URCOM, Normandie Université , Le Havre, 76600, France.|EA 3221, INC3M CNRS-FR 3038, UFR des Sciences et Techniques, Université du Havre , BP: 1123, 25 rue Philipe Lebon, F-76063 Le Havre Cedex, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lepitre
authors.affiliation: UNILEHAVRE, FR 3038 CNRS, URCOM, Normandie Université , Le Havre, 76600, France.|EA 3221, INC3M CNRS-FR 3038, UFR des Sciences et Techniques, Université du Havre , BP: 1123, 25 rue Philipe Lebon, F-76063 Le Havre Cedex, France.
authors.forename: Raphael
authors.initials: R
authors.lastname: Le Biannic
authors.affiliation: UNILEHAVRE, FR 3038 CNRS, URCOM, Normandie Université , Le Havre, 76600, France.|EA 3221, INC3M CNRS-FR 3038, UFR des Sciences et Techniques, Université du Havre , BP: 1123, 25 rue Philipe Lebon, F-76063 Le Havre Cedex, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Othman
authors.affiliation: UNILEHAVRE, FR 3038 CNRS, URCOM, Normandie Université , Le Havre, 76600, France.|EA 3221, INC3M CNRS-FR 3038, UFR des Sciences et Techniques, Université du Havre , BP: 1123, 25 rue Philipe Lebon, F-76063 Le Havre Cedex, France.
authors.forename: Ata Martin
authors.initials: AM
authors.lastname: Lawson
authors.affiliation: UNILEHAVRE, FR 3038 CNRS, URCOM, Normandie Université , Le Havre, 76600, France.|EA 3221, INC3M CNRS-FR 3038, UFR des Sciences et Techniques, Université du Havre , BP: 1123, 25 rue Philipe Lebon, F-76063 Le Havre Cedex, France.
authors.forename: Adam
authors.identifier: 0000-0002-6942-0519
authors.initials: A
authors.lastname: Daïch