title: Elevated serum IL-39 in patients with ST-segment elevation myocardial infarction was related with left ventricular systolic dysfunction.
abstract: OBJECTIVE
  To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction were investigated.
  
  
  RESULTS
  The serum levels of IL-39 in ACS patients were significantly increased. IL-39 levels were positively correlated with NTproBNP, high-sensitivity CRP and cTnI, negatively correlated with left ventricular ejection fraction in ACS patients. The most significant correlation arose between serum IL-39 and NTproBNP in STEMI patients (r = 0.8309; p < 0.0001).
  
  
  CONCLUSIONS
  Circulating level of IL-39 might be a predictor of cardiac systolic dysfunction in ST-segment elevation myocardial infarction patients.
authors.affiliation: Department of Gerontology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
authors.forename: Huadong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
authors.forename: Hongdan
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
authors.forename: Wenfei
authors.initials: W
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
authors.forename: Shaohong
authors.initials: S
authors.lastname: Dong
authors.affiliation: Department of Cardiology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, No.1017 Dongmen North Road, Shenzhen, 518020, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D000072657:ST Elevation Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D013318:Stroke Volume; D013599:Systole / Q000502:physiology*; D019210:Troponin I / Q000097:blood; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers; D007378:Interleukins; D010446:Peptide Fragments; D019210:Troponin I; C000626373:interleukin 39, human; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: IL-39; ST segment elevation myocardial infarction; acute coronary syndrome; biomarker; inflammation; left ventricular systolic dysfunction