title: Stem cell therapies for retinal diseases: recapitulating development to replace degenerated cells.
abstract: Retinal degenerative diseases are the leading causes of blindness worldwide. Replacing lost retinal cells via stem cell-based therapies is an exciting, rapidly advancing area of translational research that has already entered the clinic. Here, we review the status of these clinical efforts for several significant retinal diseases, describe the challenges involved and discuss how basic developmental studies have contributed to and are needed to advance clinical goals.
authors.affiliation: Neural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Neural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA.
authors.forename: Qingjie
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Neural Stem Cell Institute, 1 Discovery Drive, Rensselaer, NY 12144, USA sallytemple@neuralsci.org.
authors.forename: Sally
authors.identifier: 0000-0001-7301-783X
authors.initials: S
authors.lastname: Temple
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D008954:Models, Biological; D012160:Retina / Q000196:embryology / Q000473:pathology; D012162:Retinal Degeneration / Q000276:immunology / Q000628:therapy*; D033581:Stem Cell Transplantation
keywords: Degenerative retinal diseases; Macular degeneration; Regenerative medicine; Retina pigment epithelial cells; Retinal development; Stem cell