title: Effect of radiation dose reduction on texture measures of trabecular bone microstructure: an in vitro study.
abstract: Osteoporosis is characterized by bone loss and degradation of bone microstructure leading to fracture particularly in elderly people. Osteoporotic bone degeneration and fracture risk can be assessed by bone mineral density and trabecular bone score from 2D projection dual-energy X-ray absorptiometry images. However, multidetector computed tomography image based quantification of trabecular bone microstructure showed significant improvement in prediction of fracture risk beyond that from bone mineral density and trabecular bone score; however, high radiation exposure limits its use in routine clinical in vivo examinations. Hence, this study investigated reduction of radiation dose and its effects on image quality of thoracic midvertebral specimens. Twenty-four texture features were extracted to quantify the image quality from multidetector computed tomography images of 11 thoracic midvertebral specimens, by means of statistical moments, the gray-level co-occurrence matrix, and the gray-level run-length matrix, and were analyzed by an independent sample t-test to observe differences in image texture with respect to radiation doses of 80, 150, 220, and 500 mAs. The results showed that three features-namely, global variance, energy, and run percentage, were not statistically significant ([Formula: see text]) for low doses with respect to 500 mAs. Hence, it is evident that these three dose-independent features can be used for disease monitoring with a low-dose imaging protocol.
authors.affiliation: Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore.
authors.forename: Muthu Rama Krishnan
authors.initials: MRK
authors.lastname: Mookiah
authors.affiliation: Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Baum
authors.affiliation: Department of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Mei
authors.affiliation: Department of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
authors.forename: Felix K
authors.initials: FK
authors.lastname: Kopp
authors.affiliation: Department of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Kaissis
authors.affiliation: Department of Orthopaedics and Sports Orthopaedics, Biomechanical Laboratory, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Foehr
authors.affiliation: Department of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Noel
authors.affiliation: Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
authors.forename: Jan S
authors.initials: JS
authors.lastname: Kirschke
authors.affiliation: Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore. subburaj@sutd.edu.sg.
authors.forename: Karupppasamy
authors.initials: K
authors.lastname: Subburaj
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D015519:Bone Density; D000071556:Cancellous Bone / Q000033:anatomy & histology* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D011829:Radiation Dosage; D014057:Tomography, X-Ray Computed
keywords: Osteoporosis; Radiation dose; Texture analysis; Trabecular bone microstructure; Vertebra