title: Shaping proteostasis at the cellular, tissue, and organismal level.
abstract: The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates, a hallmark of aging and degenerative diseases. In multicellular organisms, the PN is regulated at the cellular, tissue, and systemic level to ensure organismal health and longevity. Here we review these three layers of PN regulation and examine how they collectively maintain cellular homeostasis, achieve cell type-specific proteomes, and coordinate proteostasis across tissues. A precise understanding of these layers of control has important implications for organismal health and could offer new therapeutic approaches for neurodegenerative diseases and other chronic disorders related to PN dysfunction.
authors.affiliation: Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208.
authors.forename: Ambre J
authors.initials: AJ
authors.lastname: Sala
authors.affiliation: Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Bott
authors.affiliation: Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208 r-morimoto@northwestern.edu.
authors.forename: Richard I
authors.identifier: 0000-0002-3431-445X
authors.initials: RI
authors.lastname: Morimoto
mesh_terms: D000818:Animals; D006706:Homeostasis; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*
chemical_list: D011506:Proteins; D020543:Proteome