title: Reactive oxygen species activated nanoparticles with tumor acidity internalization for precise anticancer therapy.
abstract: The fact that the sensitivities of different tumor cells and different individuals to the actions of drug delivery system varied greatly, restricted the anticarcinogen to a desired therapeutic concentration. How to determine the destiny of drug delivery system in space and time is the main challenge to realize the precise anticancer therapy. In this paper, we reported a preparation of degradable nanoparticles (designated Pros-PDC) loaded DOX and IR780 with three functional domains: the charge-conversional feature with long circulation time and enhanced internalization, light-triggered reactive oxygen species (ROS) generation and subsequently ROS responsive anticancer drug release with a spatially and temporally precise fashion. The spatiotemporal drug release from the ROS activated Pros-PDC nanoparticles could be controlled by when and how long to perform laser irradiation. In the present work, multifunctions of DOX and IR780 loaded Pros-PDC nanoparticles, as a flexible, easily controllable drug release platform, had been certificated in vitro and in vivo.
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
authors.forename: Hongzhang
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Liandong
authors.initials: L
authors.lastname: Deng
authors.affiliation: Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science, Peking Union Medical College, Tianjin 300192, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Polymer Science and Technology, Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.. Electronic address: ajdong@tju.edu.cn.
authors.forename: Anjie
authors.initials: A
authors.lastname: Dong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D065546:Drug Liberation; D005260:Female; D007211:Indoles / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D008027:Light; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014018:Tissue Distribution; D047368:Tumor Burden / Q000187:drug effects
chemical_list: C548458:2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindolium; D000970:Antineoplastic Agents; D007211:Indoles; D017382:Reactive Oxygen Species; D004317:Doxorubicin
keywords: Acidity internalization; DOX; Precise anticancer therapy; Reactive oxygen species (ROS); Spatiotemporal drug release