title: Fertility preservation in women with CNS tumors.
abstract: Fertility impairment due to treatments is a major concern for adolescents and young adult patients who survived cancer. Areas covered: Chemotherapy may determine a detrimental effect on ovary function, leading to infertility, and premature ovarian failure. Embryo and oocyte cryopreservation is a standard strategy for fertility preservation; other strategies, such as gonadal tissue cryopreservation and the use of gonadotropin - releasing hormone agonist, are still considered experimental. There are few data available regarding the effect of pregnancy on glioma, which indicates tumor progression during pregnancy in 33-45% of patients. Expert commentary: Glioma patients need to be advised about the risk of tumor progression during pregnancy, and about the possible, even if not proven, interaction between hormone stimulation and tumor growth.
authors.affiliation: a Medical Oncology Department , AUSL-IRCCS Scienze Neurologiche , Bologna , Italy.
authors.forename: Alicia
authors.initials: A
authors.lastname: Tosoni
authors.affiliation: b Radiotherapy Department , AUSL-IRCCS Scienze Neurologiche , Bologna , Italy.
authors.forename: Damiano
authors.initials: D
authors.lastname: Balestrini
authors.affiliation: a Medical Oncology Department , AUSL-IRCCS Scienze Neurologiche , Bologna , Italy.
authors.forename: Alba A
authors.initials: AA
authors.lastname: Brandes
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016543:Central Nervous System Neoplasms / Q000188:drug therapy*; D015925:Cryopreservation / Q000379:methods; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D005910:Glioma / Q000188:drug therapy; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced / Q000517:prevention & control; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced; D017741:Survivors; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents
keywords: Glioma; fertility; pregnancy