title: Novel GOPC(FIG)-ROS1 fusion in a pediatric high-grade glioma survivor.
abstract: Pediatric high-grade glioma is a rare tumor characterized by high mortality. The authors report the first case of a high-grade glioma associated with a GOPC(FIG)-ROS1 fusion in a pediatric patient. The patient underwent gross-total resection at the age of 4 years, followed by adjuvant high-dose chemotherapy and autologous hematopoietic stem cell rescue. At 30 months after transplantation, she remains disease free.
authors.affiliation: Departments of 1 Neurosurgery.
authors.forename: Erin N
authors.initials: EN
authors.lastname: Kiehna
authors.affiliation: University of California, Berkeley, California.
authors.forename: Maxine R
authors.initials: MR
authors.lastname: Arnush
authors.affiliation: Radiology, and.
authors.forename: Benita
authors.initials: B
authors.lastname: Tamrazi
authors.affiliation: Pathology and Laboratory Medicine, and.|Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Cotter
authors.affiliation: Pathology and Laboratory Medicine, and.
authors.forename: Debra
authors.initials: D
authors.lastname: Hawes
authors.affiliation: Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine.
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Robison
authors.affiliation: Pathology and Laboratory Medicine, and.
authors.forename: Cindy Y
authors.initials: CY
authors.lastname: Fong
authors.affiliation: Pathology and Laboratory Medicine, and.
authors.forename: Dolores B
authors.initials: DB
authors.lastname: Estrine
authors.affiliation: Pathology and Laboratory Medicine, and.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Han
authors.affiliation: Pathology and Laboratory Medicine, and.|Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles; and.
authors.forename: Jaclyn A
authors.initials: JA
authors.lastname: Biegel
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D002352:Carrier Proteins / Q000235:genetics*; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D000077614:Golgi Matrix Proteins; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D060787:Neoplasm Grading; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D017384:Sequence Deletion; D017741:Survivors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C434484:GOPC protein, human; D000077614:Golgi Matrix Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C062333:ROS1 protein, human
keywords: 6q22 deletion; CNS = central nervous system; FFPE = formalin-fixed, paraffin-embedded; GOPC; ROS1; RT-PCR = reverse transcriptase–polymerase chain reaction; RTK = receptor tyrosine kinase; oncology; receptor protein-tyrosine kinases