title: Adynamic bone disease is a predominant bone pattern in early stages of chronic kidney disease.
abstract: Chronic kidney disease (CKD) is complicated by disturbances of mineral and bone metabolism which start early in the course of the disease. It has long been assumed that high turnover bone lesions induced by secondary hyperparathyroidism are the predominant type of renal osteodystrophy from the start. However, there is increasing evidence in favor of the view that in early CKD stages low bone turnover is prevailing, with adynamic bone disease being the predominant form. Since serum parathyroid hormone levels increase progressively early on, and the most probable explanation is resistance to the skeletal action of this hormone. An early inhibition of the Wnt pathway with an increase in sclerostin and other inhibitors of Wnt signaling may be involved. Finally, a variety of other uremic toxins such as indoxyl sulfate and phosphate may play an important role in the pathogenesis of the low turnover bone disease observed in early stages of CKD. The optimal strategies to prevent and to treat adynamic bone disease in incipient CKD yet need to be defined. Targeting uremic toxins such as sclerostin, phosphate, and indoxyl sulfate may be relevant.
authors.affiliation: Division of Nephrology, Ambroise Paré Hospital, APHP, Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), 9 avenue Charles de Gaulle, 92104, Boulogne Billancourt and Villejuif Cedex, France. ziad.massy@aphp.fr.|Inserm U-1018, Team 5, Paris-Sud University (UPS) and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France. ziad.massy@aphp.fr.
authors.forename: Ziad
authors.initials: Z
authors.lastname: Massy
authors.affiliation: Inserm U-1018, Team 5, Paris-Sud University (UPS) and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France.
authors.forename: Tilman
authors.initials: T
authors.lastname: Drueke
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012720:Severity of Illness Index; D014511:Uremia / Q000097:blood* / Q000150:complications
chemical_list: C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
keywords: Adynamic bone disease; Early CKD; FGF23; Indoxyl sulfate; PTH; Renal osteodystrophy; Uremic toxins