title: Active safety monitoring of measles-mumps-rubella vaccine in the National Immunisation Programme of Sri Lanka
abstract: This study was designed to report incidence
  and characteristics of selected adverse events following
  immunisation which have consistent causal association
  (AEFIc) with Measles-Mumps-Rubella (MMR) vaccination
  given at the age of one year in the National Immunisation
  Programme of Sri Lanka.
  
  
  
  The data presented here were obtained from a
  cohort event monitoring study. It was carried out in the Jaffna
  Regional Directorate of Health Services area from November
  2012 to December 2014. A representative sample of 3002
  infants who received MMR immunisation were actively
  followed up for adverse events (AE) using over the phone
  interviews, self-reporting, and home or hospital visits up to
  45 days. All AEs were reviewed by two investigators
  independently in two step-wise processes to detect the
  AEFIc. Seven AEFIc were detected using standard case
  definitions and onset time limit criteria. They were subjected
  to further analysis to describe the incidence rates and
  characteristics.
  
  
  
  Of the 2398 (80%) infants who completed
  follow up of 45 days, 1321 infants experienced 2621
  AEFI. Of them 209 were classified as AEFIc. Incidence of
  AEFIc was 87/ 1000 immunisation. They were mainly nonserious
  and resolved completely. There were no fatal
  or life threatening AEFIs. Incidence per 1000
  immunisations; allergic reactions 0.83, injection site
  reactions 4.58, fever100.4° F or lasting more than  3 days
  9.59, macular papular rash 2.92, parotitis 2.92 and
  generalised convulsions 1.25.
  
  
  
  The MMR vaccine used in NIP of Sri Lanka had
  low incidence of AEFIc and were mainly non-serious in
  nature.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Jaffna, Sri Lanka. skumuthini79@yahoo.com
authors.forename: K
authors.initials: K
authors.lastname: Sanchayan
authors.forename: R
authors.initials: R
authors.lastname: Fernandopulle
authors.forename: A
authors.initials: A
authors.lastname: Amarasinghe
authors.forename: S N
authors.initials: S N
authors.lastname: Thiyahiny
authors.forename: S
authors.initials: S
authors.lastname: Sri Ranganathan