title: Oxidative and antioxidative status in the endometrium of patients with benign gynecological disorders.
abstract: OBJECTIVE
  Oxidative stress and impaired antioxidative system are implicated in the development of many disease states including gynecological diseases. In the present study, we aimed to investigate the oxidative-antioxidative status in endometrium of patients diagnosed with benign gynecological disorders.
  
  
  METHODS
  Samples of endometria and blood were obtained from 65 patients admitted to our center for abnormal uterine bleeding or postmenopausal bleeding. Endometrial biopsy was performed for the evaluation of histopathology and oxidative-antioxidative status in endometrial tissue. Based on histological examination, subjects were divided into groups as follows: normal controls (n=15); patients with endometrial polyps (n=20); patients with uterine myoma (n=10) patients with chronic endometritis (n=10), and patients with atrophic endometrium (n=10). Activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and total antioxidant status (TOS), total oxidant status (TAS) were assessed.
  
  
  RESULTS
  Compared to the normal controls, nonsignificant changes (decrease or increase) were detected in antioxidant enzyme activities, TAS and TOS in the examined groups. Additionally, between TAS and TOS, we also found a strong positive correlation in normal and chronic endomethritis groups and a moderate positive correlation uterine myoma, endometrial polyps and endometrial atrophy groups.
  
  
  CONCLUSIONS
  Even though, our results do not allow to conclude how oxidative and antioxidative status are influenced in benign gynecological disorders, these findings may provide a basis for the further researches.
authors.affiliation: Erzincan University, Medical Faculty, Department of Obstetrics and Gynecology, Erzincan, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Nayki
authors.affiliation: Erzincan University, Medical Faculty, Department of Obstetrics and Gynecology, Erzincan, Turkey. Electronic address: drumit75@hotmail.com.
authors.forename: U
authors.initials: U
authors.lastname: Nayki
authors.affiliation: Erzincan University, Medical Faculty, Department of Biochemistry, Erzincan, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Gunay
authors.affiliation: Erzincan University, Medical Faculty, Department of Obstetrics and Gynecology, Erzincan, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kulhan
authors.affiliation: Erzincan University, Science and Art Faculty, Department of Biology, Erzincan, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Çankaya
authors.affiliation: Erzincan University, Science and Art Faculty, Department of Biology, Erzincan, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Humeyra Taskın Kafa
authors.affiliation: Erzincan University, Medical Faculty, Department of Pathology, Erzincan, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Balci
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D005980:Glutathione Reductase / Q000378:metabolism*; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000378:metabolism*; D014591:Uterine Diseases / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
keywords: Antioxidative status; Benign gynecologic disorders; Oxidative status