title: A Review of Anti-inflammatory Terpenoids from the Incense Gum Resins Frankincense and Myrrh.
abstract: Frankincense and myrrh have been used as incense in religious and cultural ceremonies since the beginning of written history. Their common medicinal properties are used in the treatment for inflammatory conditions, some cancerous diseases, and wound healing. In the course of our characterization of the anti-inflammatory constituents from frankincense and myrrh, several terpenoid constituents were found to inhibit nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. Here we review the structure of those terpenoid constituents from the gum resins of frankincense and myrrh and evaluate their anti-inflammatory effects by their nitric oxide production inhibitory activity.
authors.affiliation: Pharmaceutical Research and Technology Institute.|Antiaging Center, Kindai University.
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.affiliation: Kyoto Pharmaceutical University.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.affiliation: Kyoto Pharmaceutical University.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D002478:Cells, Cultured; D029744:Commiphora; D003864:Depression, Chemical; D004790:Enzyme Induction / Q000187:drug effects; D065260:Frankincense / Q000737:chemistry*; D008070:Lipopolysaccharides; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D012116:Resins, Plant / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D012116:Resins, Plant; D013729:Terpenes; D009569:Nitric Oxide; C587573:myrrh resin; D052247:Nitric Oxide Synthase Type II; D065260:Frankincense
keywords: anti-inflammatory effect; frankincense; myrrh; nitric oxide inhibitor; terpenoid