title: [Validity of three methods for inmuno-diagnostic of neurocysticercosis: systematic review of the literature with meta-analysis 1960-2014].
abstract: BACKGROUND
  The screening of neurocysticercosis is complex and immunological methods have varying validity.
  
  
  OBJECTIVE
  To evaluate the validity of ELISA for antigen and antibody, and EITB for antibody in the screening of neurocysticercosis.
  
  
  METHODS
  Meta-analysis of diagnostic tests with an ex-ante protocol implemented in five databases with 15 search strategies, ensuring reproducibility in the selection and extraction of information. Sensitivity, specificity, likelihood ratios (LR), diagnostic odds ratio and ROC curve were estimated in MetaDiSc, and predictive values, and Youden index were estimated in Epidat.
  
  
  RESULTS
  EITB presented sensitivity of 85.7% (95% CI 83.5-87.7), specificity 93.9% (95% CI = 92.7-95.0), PLR 19.6 (95% CI = 8,6-44.6), NLR 0.16 (95% CI = 0.12-0.21), OR diagnostic 136.2 (95% CI = 54.7-342.6) and area under the curve 0.926. In ELISA for antibody sensitivity was 87.5% (95% CI = 86.1-88.8), specificity 92.2% (95% CI = 91.4-93.0), PLR 11.3 (95% CI = 8.45-15.11), NLR 0.15 (95% CI = 0.13-0.18), diagnostic OR 87.4 (95% CI = 60.1-127.1) and area under the curve 0.950. ELISA for antigen showed low diagnostic validity. No differences were found in these parameters by sample, antigen or antibody type.
  
  
  CONCLUSIONS
  ELISA for antibodies and EITB have a similar diagnostic value, detection of serum and CSF showed a similar validity.
authors.affiliation: Grupo de investigación Salud y Sostenibilidad, Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Jaiberth Antonio
authors.initials: JA
authors.lastname: Cardona-Arias
authors.affiliation: Grupo de investigación Salud y Sostenibilidad, Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Yoneida Elena
authors.initials: YE
authors.lastname: Carrasquilla-Agudelo
authors.affiliation: Grupo de investigación Salud y Sostenibilidad, Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia.
authors.forename: Deisy Cristina
authors.initials: DC
authors.lastname: Restrepo-Posada
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D007124:Immunoenzyme Techniques / Q000379:methods*; D020019:Neurocysticercosis / Q000175:diagnosis*; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013621:Taenia / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth