title: ADP-ribosylation: new facets of an ancient modification.
abstract: Rapid response to environmental changes is achieved by uni- and multicellular organisms through a series of molecular events, often involving modification of macromolecules, including proteins, nucleic acids and lipids. Amongst these, ADP-ribosylation is of emerging interest because of its ability to modify different macromolecules in the cells, and its association with many key biological processes, such as DNA-damage repair, DNA replication, transcription, cell division, signal transduction, stress and infection responses, microbial pathogenicity and aging. In this review, we provide an update on novel pathways and mechanisms regulated by ADP-ribosylation in organisms coming from all kingdoms of life.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: Luca
authors.identifier: 0000-0002-5556-5549
authors.initials: L
authors.lastname: Palazzo
authors.affiliation: Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia.
authors.forename: Andreja
authors.initials: A
authors.lastname: Mikoč
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: Ivan
authors.initials: I
authors.lastname: Ahel
mesh_terms: D036002:ADP Ribose Transferases / Q000235:genetics* / Q000378:metabolism; D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001105:Archaea / Q000235:genetics / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D005075:Biological Evolution; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D015870:Gene Expression; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000235:genetics / Q000378:metabolism; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011755:Pyrophosphatases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014780:Viruses / Q000235:genetics / Q000378:metabolism; D000096964:Nudix Hydrolases
chemical_list: D036002:ADP Ribose Transferases; D007527:Isoenzymes; D010727:Phosphoric Diester Hydrolases; D011064:Poly Adenosine Diphosphate Ribose; D011755:Pyrophosphatases; D000096964:Nudix Hydrolases; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1
keywords: ADP-ribosylation; cellular pathways; metabolism of ADP-ribosylation; poly(ADP-ribose) polymerase; post-translational modification