title: A Retrospective Review of Treatment Results for Patients With Central Centrifugal Cicatrical Alopecia.
abstract: <p>INTRODUCTION: Central centrifugal cicatricial alopecia (CCCA) is a form of scarring alopecia primarily affecting women of African descent on the crown of the scalp. Limited data exists regarding evidence-based treatment for CCCA.</p> <p>OBJECTIVE: To examine photos of subjects with CCCA before and after treatment in order to evaluate results of treatment and compare results of different treatment regimens.</p> <p>METHODS: Photographs of 15 subjects with CCCA before and after treatment were evaluated by two blinded investigators who assigned disease severity scores to photographs based on a published scale: Central Scalp Alopecia Photographic Scale in African American Women.</p> <p>RESUTLS: Median change in severity score (post-treatment severity score - pre-treatment severity score) was 0.5 (P = 0.58) for all 15 subjects receiving a series of 7 to 8 intralesional steroid injections along with topical steroids (Class I/II) +/- minoxidil and +/- anti-dandruff shampoo, indicating worsening of disease after treatment. Subjects receiving minoxidil versus those who did not (0.25 vs 0.5; P = 0.38) and subjects receiving anti-dandruff shampoo versus those who did not (0.0 vs 0.5; P = 0.42) demonstrated no statistically significant difference in pre- and post-treatment severity scores. Of 15 subjects, 5/15 (33.3%) had decreased severity scores, 8/15 (53.3%) had increased severity scores, and 2/15 (13.3%) had no change in severity scores.</p> <p>CONCLUSIONS: Although no statistically significant difference was found in pre- versus post-treatment disease severity, this may indicate intralesional steroid injections and topical steroids +/- minoxidil and +/- anti-dandruff shampoo halt disease progression.</p> <p><em>J Drugs Dermatol. 2017;16(4):317-320.</em></p>.
authors.forename: Ariana
authors.initials: A
authors.lastname: Eginli
authors.forename: Emily
authors.initials: E
authors.lastname: Dothard
authors.forename: Courtney W
authors.initials: CW
authors.lastname: Bagayoko
authors.forename: Karen
authors.initials: K
authors.lastname: Huang
authors.forename: Alyssa
authors.initials: A
authors.lastname: Daniel
authors.forename: Amy J
authors.initials: AJ
authors.lastname: McMichael
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001741:Black or African American; D000505:Alopecia / Q000188:drug therapy* / Q000473:pathology; D001706:Biopsy; D044383:Black People; D002921:Cicatrix / Q000188:drug therapy* / Q000473:pathology; D019317:Evidence-Based Medicine / Q000379:methods*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006203:Hair Preparations / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D015552:Injections, Intralesional; D008875:Middle Aged; D008914:Minoxidil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010781:Photography; D012189:Retrospective Studies; D012535:Scalp; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D006203:Hair Preparations; D008914:Minoxidil