title: Whole liver engineering: A promising approach to develop functional liver surrogates.
abstract: Liver donor shortage remains the biggest challenge for patients with end-stage liver failures. While bioartificial liver devices have been developed as temporary supports for patients waiting for transplantation, their applications have been limited clinically. Whole liver engineering is a biological scaffold based regenerative medicine approach that holds promise for developing functional liver surrogates. Significant advancements have been made since the first report in 2010. This review focuses on the recent achievements of whole liver engineering studies.
authors.affiliation: Organ Transplantation Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.|Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
authors.forename: Fanwei
authors.identifier: 0000-0002-5467-7311
authors.initials: F
authors.lastname: Meng
authors.affiliation: Organ Transplantation Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
authors.forename: Abdallah
authors.initials: A
authors.lastname: Assiri
authors.affiliation: Organ Transplantation Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.|Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
authors.forename: Dipok
authors.initials: D
authors.lastname: Dhar
authors.affiliation: Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
authors.forename: Dieter
authors.initials: D
authors.lastname: Broering
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D006801:Humans; D008099:Liver; D016031:Liver Transplantation; D023822:Tissue Engineering; D054457:Tissue Scaffolds
keywords: decellularization; endothelialization; recellularization; transplantation; whole liver engineering