title: Progressive visual disturbance and enlarging prolactinoma caused by melanoma metastasis: A case report and literature review.
abstract: BACKGROUND
  Melanoma metastases to the pituitary adenoma (MMPA) are extremely rare, with only 1 reported case. To date, the melanoma metastasis to the existing prolactinoma has not been reported in literatures.
  
  
  METHODS
  We report a case of 62-year-old woman presented with progressive visual disturbance and hyperprolactinemia. Magnetic resonance imaging demonstrated the presence of a round sellar mass.
  
  
  METHODS
  Melanoma metastasis to the pituitary adenoma.
  
  
  METHODS
  Surgery was performed and intraoperative frozensection examination found melanin granules and histopathological examination confirmed melanoma metastasis to the pituitary adenoma.
  
  
  RESULTS
  After surgery, the patient developed widespread melanoma metastasis to lower limbs. Twenty-two months later, the patient was alive with worse symptoms.
  
  
  CONCLUSIONS
  We reviewed and analyzed the clinical data, imaging features, and treatment methods of other reported cases of metastases to pituitary adenoma (MPA). This study provides clinical information for the diagnosis and management of MMPA.
authors.affiliation: Department of Neurosurgery of the Second Affiliated Hospital Institute of Cancer Stem Cell Department of Endocrinology of Affiliated Dalian Municipal Central Hospital, Dalian Medical University, Dalian, Liaoning Province Department of Neurosurgery of Yantaishan Hospital, Yantai, Shandong Province, PR China.
authors.forename: Chuanwei
authors.initials: C
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Lan
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Zhang
authors.forename: Xinyu
authors.initials: X
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
mesh_terms: D005260:Female; D006801:Humans; D008545:Melanoma / Q000556:secondary*; D008875:Middle Aged; D010902:Pituitary Gland / Q000473:pathology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000473:pathology / Q000556:secondary; D015175:Prolactinoma / Q000150:complications* / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D014786:Vision Disorders / Q000209:etiology*