title: Septic shock due to NSTI caused by Actinomyces Turicensis: the role of clinical pharmacology. Case report and review of the literature.
abstract: Critical septic patients affected by necrotizing soft tissue infections (NSTI) require an early, aggressive and multidisciplinary treatment. Pharmacokinetic alterations in antibiotic therapy are peculiar in these infections. Clinical pharmacology represents a first step in this setting. We report a case of septic shock due to NSTI in which clinical pharmacology is taken into account.
authors.affiliation: a Department of Oncology and Hemato-oncology , University of Milan , Milan , Italy.
authors.forename: Milo
authors.initials: M
authors.lastname: Gatti
authors.affiliation: b Intensive Care Unit 1 , ASST Grande Ospedale Metropolitano Niguarda , Milan , Italy.
authors.forename: Laura Elisa
authors.initials: LE
authors.lastname: Gasparini
authors.affiliation: c Department of Clinical Microbiology , ASST Grande Ospedale Metropolitano Niguarda , Milan , Italy.
authors.forename: Chiara Maria
authors.initials: CM
authors.lastname: Grimaldi
authors.affiliation: d Department of Diagnostic Radiological , ASST Grande Ospedale Metropolitano Niguarda , Milan , Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Abbati
authors.affiliation: e Intensive Care Unit , ASST Nord Milano Città Sesto San Giovanni , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Clemente
authors.affiliation: b Intensive Care Unit 1 , ASST Grande Ospedale Metropolitano Niguarda , Milan , Italy.
authors.forename: Paolo Riccardo
authors.initials: PR
authors.lastname: Brioschi
authors.affiliation: b Intensive Care Unit 1 , ASST Grande Ospedale Metropolitano Niguarda , Milan , Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Fumagalli
authors.affiliation: a Department of Oncology and Hemato-oncology , University of Milan , Milan , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Scaglione
mesh_terms: D000190:Actinomyces; D000196:Actinomycosis / Q000150:complications* / Q000628:therapy; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003646:Debridement; D005260:Female; D006801:Humans; D008875:Middle Aged; D010601:Pharmacology, Clinical; D012772:Shock, Septic / Q000382:microbiology* / Q000628:therapy; D018461:Soft Tissue Infections / Q000382:microbiology* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D000667:Ampicillin
keywords: Actinomyces turicensis; Clinical pharmacology; Necrotizing soft tissue infections; Therapeutic drug monitoring