title: ATAC-seq of mus musculus:adult male liver
design: we fed C57BL/6 mice  with HFD for 8weeks. Then one group mice were treated with BMP9 by intraperitoneal injection. We found that  BMP9 expression downregulated in HFD mice;BMP9 reduced obesity, improved  glucose handling ability and alleviated liver steatosis in HFD mice.Then we  observed the changes of chromatin accessibility of HFD mice after BMP9 treatment  by ATAC-seq.