design:   Illumina sequencing of H. sapiens DNA random fragment library enriched for exome sequences by solid-phase hybrid capture.  Human genomic DNA is prepared as a standard in vitro shotgun sequencing library.  Amplified library is hybridized to one of two 244K Agilent microarrays with features designed to correspond to human coding sequences (NCBI CCDS 2008).  Hybridizations are carried out in the presence of excess blocker oligos corresponding to all adaptor sequences to limit "daisy-chaining" between complementary adaptor sequences that can lead to non-specificity.  Post-capture library molecules are eluted and subjected to massively parallel sequencing.       