title: 16S rRNA amplicon analysis of  ocean acidification minicosm experiment on marine microbes
design: 1.6.18 0.1um, 15.18 0.1um,  1.1.18 0.1um, 1.2.18 0.1um, 1.1.18 3.0um, 1.2.12 3.0um, 1.2.18 3.0um, 1.3.18  3.0um, 1.5.18 3.0um, 1.6.18 3.0um