title: Whole exome sequencing
design: WES was operated with an Illumina HiSeq 2500 system (Illumina). The bcl2fastq2 Conversion Software (v2.20) was employed for extracting Fastq files. BWA (v0.2.10) was used for genome alignments and variant detection. Clinic Sequence Analyzer (CSA) software was employed for biological analysis and interpretation