title: Exome sequencing of LuCaP86.2 prostate cancer xenograft line
design: The Nimblegen EZ SeqCap kit (Roche) was used as previously described in order to capture exons (39). Shotgun libraries were constructed by shearing gDNA and ligating sequencing adaptors. Libraries were hybridized to the EZSeqCap V1 solution-based probes, amplified and sequenced on the Illumina platforms. See "Exome Sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers" for more details