title: Hi-C crosslink tests, 3% 10 minutes
design: Hi-C libraries were sheared and processed into Illumina libraries using custom-made versions of the Illumina PE adapters (Paired-End DNA sample Prep Kit Illumina PE-930-1001). Fragments of sizes between 400 and 800 bp were purified using a PippinPrep apparatus (SAGE Science). Biotinylated molecules were purified using Dynabeads MyOne Streptavidin C1 beads, PCR amplified, and paired-end sequenced on an Illumina platform