title: 25-75_NA12878_NA12890 MiSeq
design: Sequence data from jumping library generated in the procedure of Talkowski et al.  See   http://www.ncbi.nlm.nih.gov/pubmed/21473983 and http://www.ncbi.nlm.nih.gov/pubmed/24789519 for library details.  This jumping library method is based on circularization of long DNA fragments using a biotinylated linker with a pair of EcoP15I recognition sites. EcoP15I cuts 25/27 nucelotides away, resulting in double stranded fragments that look like:  5' XXXXXXXCTGCTGTACCGTTCTCCGTACAGCAGXXXXXXXX 3' 3' XXXXXXXGACGACATGGCAAGAGGCATGTCGTCXXXXXXXX 5' Where XXX is 27 nucleotides of DNA at opposite ends of the original fragment.  This sample represents a mixture of 25% NA12878 and 75% NA12890