title: Condensin mediates long-range gene associations and controls cell cycle-specific transcription factors: Cut14_bio1
design: It is becoming clear that the Structural Maintenance of Chromosomes (SMC)-containing complex, such as condensin and cohesin, are heavily involved in three-dimensional genome organization, while the exact roles of these complexes in the functional organization remain elusive.  This study employs a ChIA-PET approach to comprehensively identify genome-wide associations mediated by condensin and cohesin in fission yeast.  We find that condensin and cohesin mostly bind to the same loci, but they direct different association networks and generate different sizes of chromatin domains.  Cohesin mediates local associations between loci positioned within ~ 100 kb, while condensin can function in longer-range associations.  Condensin, but not cohesin, connects particular groups of genes bound by the two cell cycle-specific transcription factors, Ace2 and Ams2.  This study describes functions of condensin in long-range gene associations and in the cell cycle-dependent regulation of the transcription factors.