title: Illumina HiSeq 2000 paired end sequencing; Concurrent DNA copy number alterations and mutations in genes related to maintenance of genome stability in uninvolved glandular tissue from breast cancer patients.
design: Concurrent DNA copy number alterations and mutations in genes related to maintenance of genome stability in uninvolved glandular tissue from breast cancer patients.
library_construction_protocol: A custom SureSelect target enrichment library (design ID 0488011) was designed using the SureDesign online tool (Agilent Technologies, https://earray.chem.agilent.com/suredesign/). The library consisted of 42155 probes (2.6 Mbp) which encompassed 301 targets comprising 3059 genomic regions at 97.5% average coverage. The library targeted exonic as well as noncoding elements that were previously identified as predisposition loci, or were affected by somatic driver mutations in breast cancer.
attributes.tag: Experimental Factor: genotype
attributes.value: Copy Number Alterations: 56
attributes.tag: LIBRARY_STRAND
attributes.value: not applicable