title: GFD-5
design: Ptch;p53 spontaneous MB was first minced into a slurry, and equivalent pools of tumor cells were injected into male or female 6- to 8-week-old NSG mice. When the tumor volume reached 100-200 mm3, mice were treated with 40 mg/kg LDE225 or vehicle control (oral gavage, every three days) until harvest. At IACUC endpoint.