title: mouse fed with natural diet rep3
design: The experiment protocols and procurers were performed within the guidelines of the Au-thority for Biological and Biomedical Models and approved by the Institutional Animal Care Ethics Committee, both of the Hebrew University of Jerusalem (AG-14922-2). 48 Male C57BL/6J mice, 4-5 weeks old, were purchased from Harlan Laboratories (Jerusalem, Isra-el). Following the acclimatization period mice were randomly divided into two experi-mental groups: 1) mice fed normal diet (ND, n =8) and 2) mice fed high fat diet (HFD, n=40) for 12 weeks. At week 13 of the experiment, HFD mice were divided into 4 groups receiving the following diets for 6 weeks: 1) mice continuing to receive HFD (HFD, n=8), 2) mice fed HFD supplemented with 5 mg /kg BW of CN1 plant extract (HFD + CN1 , n=10), 3) mice fed HFD supplemented with 5 mg /kg BW of CN2 plant extract (HFD + CN2 , n=10) and 4) mice fed HD supplemented with 5 mg /kg BW of CN6 plant extract (HFD + CN6 , n=10