library_construction_protocol: RNA was extracted using the RNeasy plus mini kit from Qiagen. RNA-seq experiments were carried out by the Centre d'Expertise et de Services Genome Quebec (GC) using rRNA-depleted TruSeq stranded (HMR) libraries (Illumina) on an Illumina Hiseq 4000 instrument (paired-ends, 100-bp reads) and by The Center for applied Genomics (TCAG, Toronto) using rRNA-deletion library prep on an Illumina NovaSeq-SP flow cell.