library_construction_protocol: RNA was isolated using the RNeasy Mini Kit (Qiagen, Hilden, Germany) The RNA quality control, library preparation (QuantSeq 3'-mRNA Library Prep (Lexogen, USA)) and RNA sequencing were performed by the Core Facility Next Generation Sequencing (University of Bonn, Germany). An Illumina HiSeq 2500 V4 device (producing >10 million, 50bp 3'-end reads per sample) was used.