title: T18
design: Hypoxia plays an essential role in the progression of hepatocellular carcinoma (HCC), whereas hypoxia inducible factor-1 (HIF-1) is the key transcription factor allowing the HCC to survive hypoxia. The aim of this study was to define the essential mRNAs and miRNAs regulated by HIF9A and to dissect their functions, interactions and tumor-infiltrating immune cells in the HCC.