library_construction_protocol: RNA was harvested using Direct-zol RNA Microprep kit (Zymo Research). 1 ug of total RNA was used for the construction of sequencing libraries. Leukemia sample RNA was harvested using Qiagen RNA kit (Qiagen) and 1 ug of total RNA was used for sequencing libraries. RNA libraries for RNA-seq were prepared using TruSeq RNA Library Prep Kit v2 (Illumina) following manufacturer's protocols.