library_construction_protocol: 30 million cells were collected for JQ1 at day 14 and CPI0610 at day 21. DNA was extracted by desalting method 50 microgramms of DNA were used to PCR amplify library using Herculase II enzyme following published protocols and instructions supplied by authors on Addgene  (Shalem, et al Science 2014. 343(6166): p. 84-87, Tzelepis et al, Cell Rep, 2016. 17(4): p. 1193-1205) Shalem et al Science 2014. 343(6166): p. 84-87