library_construction_protocol: QIAamp Circulating Nucleic Acid kit (Qiagen, Cat. No. 55114). Accel-NGS R Methyl-Seq DNA Library Kit, (Swift Biosciences, Cat. No. 30024) and Accel-NGS Methyl-Seq Dual Indexing kit (Swift Biosciences, Cat. No. 38096)