library_construction_protocol: MNase-seq were generated using the protocol described in Gevry, N., Methods Mol Biol, 2009. Mononuclesoome fractions were isolated and purified. MNase DNA libraries were generated using the ThruPLEX DNA-seq kit (RUBICON GENOMICS, cat. R400406) and quantified by the NEBNext Library Quant Kit (cat. E7630L). Equal amounts of DNA were pooled from each library with different dual indexing primers and sequenced on a Next seq 500.