library_construction_protocol: HA-TRβ and H3K27ac ChIP-seq were performed as previously described (Armour et al., 2017). Magnetic beads (Pierce) were used to perform the immunoprecipitation with H3K27ac antibody (Active Motif, Cat #: 39133) or HA aagnetic beads (Pierce) . For ChIP-seq of HA-TRβ, 3 biological replicates were used for sequencing, and WT mice were used as negative control. The ChIP-seq library has been performed as previously described (Armour et al., 2017)