library_construction_protocol: Total RNA was extracted from 3 separate samples of control CDCs and 5-aza treated CDCs at passage 30 using Trizol(Life science)and DNA-free kit(Ambion). Sequencing libraries were generated using NEBNext® UltraTM RNA Library Prep Kit for Illumina® (NEB, USA) following manufacturer'srecommendations and index codes were added to attribute sequences to each sample.