title: Modelling Multi-Dimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: Sample CL0121_T1D
design: Genomic DNA was extracted from patient's blood using Paxgene blood DNA kits. One hundred nanograms of DNA was sheared to approximately 200 base pairs (bp) by sonication (Covaris, Woburn, MA). Exome enrichment was performed using SureSelect Clinical Research Exome Kits according to the manufacturer's instructions (Agilent, Santa Clara, CA) . Paired-end sequencing (2X75 bp) was performed on an Illumina NextSeq500 instrument.