design: Briefly, bacterial genomic DNA was extracted using PowerSoil DNA Isolation Kit (Qiagen). Metagenomic library was constructed with Illumina barcodes from the Nextera XT kit (Illumina, San Diego, CA) and then loaded into Illumina Hiseq 4000 platform using 2 x 150 nucleotide pair-ending sequencing protocol at Weill Cornell Microbiome Core Facility.