title: Direct prediction of carbapenem-resistance for Pseudomonas aeruginosa by whole genome sequencing and metagenomic sequencing
design: Carbapenem-resistance is a major concern in the management of antibiotic resistant Pseudomonas aeruginosa infections. Direct prediction of carbapenem-resistance phenotype from genotype in P.aeruginosa isolates and clinical samples would promote timely antibiotic therapy. While the complex carbapenem-resistance mechanism and the high prevalence of variant-driven carbapenem-resistance in P.aeruginosa make it challenging to predict its carbapenem-resistance phenotype through genotype.