scRNA-seq were performed with Lin- c-Kit+ HSPCs from Mx1-Cre+ wild-type (WT), Mx1-Cre+ Srsf2P95H/+, Mx1-Cre+ Setd2fl/fl Srsf2P95H/+ mice bone marrow at 4 weeks post pIpC induction in BMT model. The scRNA-seq libraries were constructed according to the protocol of the GEXSCOPE® Single Cell RNA Library Kits (Singleron) according to the manufacturer's recommendations. RNA-Seq: mRNA libraries were sequenced with Illumina NovaSeq 6000.