Native cells were harvested and 0.4x10^6 cells/per sample were used using standard CUT&RUN protocol: https://www.protocols.io/view/cut-amp-run-targeted-in-situ-genome-wide-profiling-zcpf2vn Histone modifications were mapped with the standard CUT&RUN library prep protocol:  https://www.protocols.io/view/library-prep-for-cut-amp-run-with- nebnext-ultra-ii-wvgfe3w (2019)