Total RNAs were extracted from blood using TRIzol Reagent (Invitrogen, cat. NO 15596026) following the methods by Chomczynski et al. (DOI:10.1006/abio.1987.9999). 2 μg total RNAs were used for the construction of sequencing libraries. 2 μg total RNAs were used for stranded RNA sequencing library preparation using KC-DigitalTM Stranded mRNA Library Prep Kit for Illumina® (Catalog NO. DR08502, Wuhan Seqhealth Co., Ltd. China) following the manufacturer's instruction.