library_construction_protocol: The total RNA from B16-F10 or A375 cells was extracted by trizol(Vazyme) according to manufacturer's protocol for RNA-seq.  For chip-seq, B16-F10 cells were fixed by 1% formaldehyde for 10 minutes. Then, chromatin from cells lysate was digested by Micrococcal Nuclease  into DNA fragments between 150-900 bp in length and released by sonication for antibody enrichment. RNA libraries for RNA-seq were prepared using VAHTS Universal V6 RNA-seq Library Prep Kit for Illumina(Vazyme) following manfacturer's protocl.