library_construction_protocol: RNA of cells was extracted by TRIzol (Thermo Fisher Scientific, 15596026, USA,) and sent to the company (Novogene) to perform a standard RNA-sequencing procedure. RNA-seq libraries were constructed using a NEBNext® UltraTM RNA Library Prep Kit for Illumina® (NEB, USA). The library preparations were sequenced on an Illumina Novaseq 6000 platform, and 150 bp paired-end reads were generated.