library_construction_protocol: 5×106 cells were used. Resuspended crosslinked cells (method described as above) in 20 μL of Lysis Buffer in a tube HiChIP was performed using the Arima Hi-C+ Kit (Arima Genetics Inc. Cat# A101020) precisely following the manufacturer's protocols (Arima-HiC+ documents A160168 v00 (HiChIP) and A160169 v00 (library preparation)).