library_construction_protocol: RNA was extracted using the Direct-zol miniRNA kit (Zymo) and samples with RIN>9 were submitted to Quick Biology for library preparation, RNA sequencing and preliminary analysis. Total RNA integrity was checked by Agilent Bioanalyzer 2100 and samples with clean rRNA peaks (RIN>6.5) were used for library preparation. RNA-Seq library was prepared according to the KAPA mRNA HyperPrep kit with 200-300 bp insert size using 500 ng of total RNAs as input. Final library quality and quantity were analyzed by Agilent Bioanalyzer 2100 and Life Technologies Qubit 3.0 Fluorometer.