library_construction_protocol: Cells were fixed with 2 µM EGS (ethylene glycol bis (succinimidyl succinate)) for 1 hour, followed by 1% formaldehyde for 15 minutes. After quenching and cell lysis, chromatin was sonicated using a Bioruptor Pico sonication device (Diagenode). ChIP-seq libraries were prepared using the MicroPlex Library Preparation Kit v3 (Diagenode #C05010002), complemented with 24 UDI for MicroPlex vs - Set I and Set II (Diagenode #C05010008/C05010009). 13.5 µg and 1 µg of chromatin per IP were used as starting material for Kdm2a and H3K36me2, respectively. Libraries were amplified using 9-10 and 10-11 cycles on the thermocycler for H3K36me2 and Kdm2a/input, respectively. Post-amplification libraries were purified using AMPure beads, and the purified libraries were quantified using the Qubit ds DNA HS Assay kit (Invitrogen, #Q32851). Libraries were in size between 350-460bp in length.