library_construction_protocol: Total RNA was extracted from cells or tissues using TRIzol (Aidlab. biotech) RNA-seq libraries were constructed with NEBNext Poly(A) mRNA Magnetic Isolation Module (NEB E7490) and NEBNext Ultra II Non-Directional RNA Second Strand Synthesis Module (NEB E6111). RNA-seq libraries were sequenced by Illumina Nova-seq platform with pair-end reads of 150 bp. Quality control of mRNA-seq data was performed using Fatsqc