library_construction_protocol: RNA was isolated from blood samples stored in Paxgene tubes according to the manufacturers' instructions (Qiagen) Globin transcripts in blood RNA were blocked with the Ribo-Zero Globin (Illumina) before library preparation. Libraries were prepared using the TruSeq Stranded Total RNA library preparation kit (Illumina) RNA-Seq, libraries were sequenced on an Illumina Next Seq 550.