library_construction_protocol: ATAC-seq libraries (replicates, n = 3) were generated from transposed DNA using the Nextera DNA Library Preparation Kit (Illumina) according to the manufacturer's recommendations. ATAC-seq libraries were further purified using the MinElute PCR Purification Kit (Qiagen) and sequenced on Novaseq 6000 using PE150 with an average of 80 million reads per sample.