library_construction_protocol: Total RNA was extracted from the treated BearF cells with F from day 0 , day 3 and day 6 using TRIzol Reagent according the manufacturer's instructions (Invitrogen) and genomic DNA was removed using DNase I (TaKara). RNA libraries for RNA-seq were prepared using Ribo-Zero TM Magnetic Kit (Epicentre, Madison, WI, USA) following manufacturer's protocols.