library_construction_protocol: A549 cells were fixed with 1% formaldehyde for 10 minutes, then glycine at 0.125 M was added. After cellular lysis, chromatin was sonicated using a VCX130PB vibra cell (Sonics). The DNA size profile was evaluated in a bioanalyzer 2100 (kit High Sensitivity DNA Reagent Agilent No. Cat. 50674626), for the libraries assemble the kit Truseq Chip de Illumina (No. Cat. IP-202-1012) was used, using a total of 10 ng. Cutted DNA fragments were performed from 300 to 500 bp, the distribution of the amplified libraries were evaluated by TapeStation 4200 (kit High Sensitivity DNA Reagent Agilent Technologies No. Cat. 5067- 5585), the final loading concentration was of 1.5 pM and a 30% of control PhiX was included. For the sequenciation we used a kit Nextseq 500/550 High Output (150-cycles) Flow Cell (No. Cat. FC-404-202, 20024904).