library_construction_protocol: In vivo scRNA-seq was performed using the GEXSCOPE Single Cell RNA Library Kit Cell V2 reagents (Singleron Biotechnologies GmbH). In vitro single-cell ATAC+gene multiome was performed using the Chromium Next GEM Single Cell Multiome ATAC + Gene Expression kit (10x Genomics, Cat# PN-1000283) Libraries were constructed according to the protocols provided by the aforementioned kits. scRNA-seq and single cell ATAC+Gene multiomics