library_construction_protocol: Biopsies were bead beat 3 times for 1 minute at a setting of nine on a Bullet Blender 24 (Next Advance), with one minute of cooling on ice between each beating. Lysates were processed using the AllPrep DNA/RNA/miRNA Universal Kit (Qiagen). 500ng of purified RNA was used as input TruSeq Stranded mRNA Library Prep kit (Illumina) to generate sample libraries according to manufacturer's specifications. Libraries were multiplexed and sequenced at a depth of 20 million reads per sample (50 base pairs, single read) on a HiSeq4000 sequencer.