library_construction_protocol: RNA was extracted with RNeasy Mini Kit (QIAGEN) and RNA integrity was assessed using the Agilent 4150 TapeStation (Agilent). Libraries were prepared according to TruSeq Stranded Total RNA Library Prep Human/Mouse/Rat (Illumina Inc.) system. Paired-end sequencing was performed using Illumina NextSeq500 High Output 150-cycle (2x75bp) sequencing (Illumina Inc.).