library_construction_protocol: Prior to performing spatial transcriptomics experiment, DV200 assessment was done on all the samples with a minimum criterion set at 30%. RNA was extracted from paraffin curls (4 curls at 10µm per tissue) using Qiagen's RNeasy Mini Kit (Cat#74104). All working space and instruments were treated with RNase zap (Invitrogen, Cat#AM9780) prior to RNA extraction, and gentle scoring was performed around the tissue to minimize excess paraffin during curl collection Spatial transcriptomics experiment was performed using Visium Spatial Transcriptomics (10X genomics, Cat#1000185), following materials and methods according to the manufacturer's website (User Guide, CG000407).