library_construction_protocol: Total RNA was extracted from WBC using Macherey-Nagel's NucleoSpin® miRNA kit and RNA/DNA Buffer kit (Takara Bio USA, Inc. Doral, Fl, USA) according to manufacturer's guidelines. The RNA integrity was tested using an Agilent bioanalyzer system, and all samples that had an RNA integrity number (RIN) greater than seven were used for sequencing. Libraries were prepared according to Illumina's instructions Strand-specific RNAseq