library_construction_protocol: The total RNA from B16-F10 or A375 cells was extracted by trizol(Vazyme) according to manufacturer's protocol for RNA-seq.  For chip-seq, B16-F10 cells were fixed by 1% formaldehyde for 10 minutes. Then, chromatin from cells lysate was digested by Micrococcal Nuclease  into DNA fragments between 150-900 bp in length and released by sonication for antibody enrichment. DNA libraries for chip-seq were estabished using VAHTS Universal DNA Library Prep Kit for Illumina V3 (Vazyme) following the manufacturer's guidelines. Equal amount of each library was sequencing on lIIumina NovaSeq 6000. The first sequencing data was not sufficient for data analysis, the second sequencing was performed.