library_construction_protocol: Total RNA was extracted from the VSMCs of Cmklr1-/- and Cmklr1+/+ mice following standard protocols of RNA isolation. Quantification and quality of RNA was assessed. The library preparation and sequencing were performed by Wenzheng Biotechnology Co., Ltd. on an Illumina NovaSeq platform following the manufacturer's instructions, and the paired-end reads were generated. The raw data were stored as FASTQ files.