library_construction_protocol: Lin- Sca1+ cKit+ HSPCs were purified from the bone marrow of DRAG mice by fluorescence-activated cell sorting. Cells were then processed as per the manufactureres guidelines (single cell 3' v2-v3 protocol, 10x Genomics) Library was performed according to the manufacter's instructions (single cell 3' v2-v3 protocol, 10x Genomics).