library_construction_protocol: Total RNA was isolated from AML cell linesusing Trizol Reagent (Life technologies) following the manufacturer's instructions. RNA quality (the RNA integrity number [RIN]) was assessed using an Agilent Bioanalyzer, and all samples were evaluated as RIN >8. RNA sequencing libraries were prepared using a Kapa mRNA HyperPrep kit (Roche) and sequenced on a HiSeq 2500 system (Illumina).