library_construction_protocol: Cells were centrifuged and homogenized using QIAshredder (Qiagen). RNA was isolated with RNeasy Micro Kit (Qiagen) according to manufacturer's instructions. RNA quality and quantity were assessed by Bioanalyzer using Agilent RNA 6000 Pico Kit (Agilent Technologies). Samples used for analysis had RIN ≥ 6.4. NGS libraries with polyA capture were prepared according to the manual NEBNext® Ultra™ II Directional RNA. Library Prep Kit for Illumina® (New England Biolabs) (Version 4.0, 4/21) RNA-seq (polyA capture)