library_construction_protocol: Biopsies were bead beat 3 times for 1 minute at a setting of nine on a Bullet Blender 24 (Next Advance), with one minute of cooling on ice between each beating. Lysates were processed using the AllPrep DNA/RNA/miRNA Universal Kit (Qiagen). 500ng of purified RNA was used as input TruSeq Stranded mRNA Library Prep kit (Illumina) to generate sample libraries according to manufacturer'