library_construction_protocol: DNA extraction for single-cell RepliSeq was conducted following established protocols as described in a previous publication (PMID: 33230331). Library construction was carried out using the protocols established by Miura et al., 2020 (PMID: 33230331), incorporating IDT for Illumina unique dual indexes and the KAPA Hyper Prep Kit from Roche. single cell RepliSeq