library_construction_protocol: Plaques were micro-dissected from the aorta (root, arch) and carotid arteries of Trf2T188A/ApoE-/- and  ApoE-/- mice before enzymatic digestion and single cell suspensions were analyzed using the 10X Genomics Chromium system as described (Dobnikar et al). Cells were loaded onto a Chromium system (10x Genomics) and amplified cDNA libraries generated using Single Cell 3' v3 kit (10x Genomics) were sequenced using NovaSeq (Illumina).