library_construction_protocol: Cells were harvested at day 14 by the addition of TRIzol to the cultures (Invitrogen). RNA harvested in TRIzol (Invitrogen) was isolated using the RNA Miniprep kit (Zymo Research). For bulk RNA sequencing, libraries were prepared according to the dUTP protocol and paired-end sequencing (2x100bp) was performed on the NovaSeq 6000 platform (Illumina).