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design: To eliminate possible reagent contaminants, we included a sterile water as control. The ribosomal RNA was removed for library construction by the NEBNext rRNA Depletion Kit (NEB, USA). Sequencing libraries were generated using RNA Library Prep Kit for Illumina(NEB, USA), following the manufacturers recommendations. Then, the 150 bp paired-end sequencing of the RNA libraries was performed using the Illumina NovaSeq platform (Illumina, USA) at Novogene (Beijing, China).