title: Characteristics of baseline gut microbiota determine the efficacy of lifestyle intervention in patients with gestational diabetes mellitus
design: We used longitudinal research methods and prospective research methods to conduct well-controlled lifestyle interventions in GDM patients who did not receive drug treatment, followed by comprehensive metagenomic sequencing and metabolomic analysis. Changes in functions, pathways, and metabolism, using a longitudinal prospective study approach, focusing on the differences and Intrinsic links to explore the impact of different gut microbial signatures and their changes on lifestyle interventions promoting glucose metabolism and improving insulin sensitivity.