title: 15
design: We used illumina sequence to perform RNA sequence upon colon tissue from mice. We set four groups, one is mice without any treatment(control group); one is mice with CR-Hvkp 1 infection; one is mice with oral drug ZDV+RIF (Drug group); the last one is mice with CR-Hvkp 1 infection and treatment with drug (Treatment group). Gene expression level was compared between each other and we found most genes have upregulated when bacteria infection, and also many genes have downregulated with drug treatment.