title: female children Peripheral blood
design: Genomic DNA samples were extracted from peripheral blood using QIAamp Blood Mini Kit (Qiagen, Hilden, Germany). Quality of genomic DNA was evaluated by agarose gel analysis and quantity was measured by NanoDrop2000 and Qubit3.0. DNA is Sheared with M220 Focused-ultrasonicator (Covaris, Woburn, MA, USA). DNA target regions were captured by hybridizing the genomic DNA sample library with the xGen Exome Research Panel v1.0 (IDT, USA). The captured and amplified DNA samples were sequenced using Illumina NovaSeq6000 (Illumina, California, USA) with 150 base-paired end reads.