design: Genomic DNA was extracted from tissue using the DNeasy Blood & Tissue Kit (Qiagen). DNA was sheared to ~500 bp using a Covaris S220 Focused-ultrasonicator and purified with Sartorius VIVACON 500 (Fisher Scientific). Library preparation was performed using the ThruPlex DNA-Seq Kit (Takara Bio), followed by quality control on an Agilent 2100 Bioanalyzer with the DNA 7500 Kit. The library was sequenced on an Illumina NextSeq 500 platform using a High Output Flow Cell v2.5 with 300 cycles, generating paired-end reads.