design: Total RNA was extracted from CBP-Exos and OBP-Exos derived from three different donors, respectively.  Exosomal MiRNAs high-throughput sequencing were performed by BGI Technology Co., LTD (Beijing, China).  The project was sequenced using the MGI2000 high-throughput platform with a sequencing length of SE50.  Reads containing low quality, joint contamination and high content of unknown base N were filtered out after sequencing to ensure the reliability of the sequences.  Data were analysis in the multi-omics data system Dr.Tom of BGI.