design: The DNA samples were normalised and sheared via sonication into approximately 350 bp fragments. This was followed by DNA end-repairing, dA-tailing, and ligation with Illumina-compatible adapters. Quality control of the constructed libraries was performed by Qubit 2.0 and Agilent 2100 Bioanalyzer, followed by a real-time qPCR. Uniquely indexed samples were pooled and sequenced on NovaSeq 6000, using an S4 flow cell, generating approximately 1 Gigabase of 2 x 150 paired-end reads per sample.