design: Sequencing libraries for RNA were prepared using the NEBNext Ultra II RNA Library Prep Kit (New England Biolabs, MA, USA). Library concentration and insert size were measured using the Qubit 3.0 fluorometer (ThermoFisher Scientific, USA) and 2100 Bioanalyzer (Agilent Technologies, USA), respectively. Paired-end sequencing was conducted on the IlluminaHiSeq 2500 (Illumina, San Diego, CA, USA) with 150 X 2 bp reads.