title: GSM9341667: ABE_Digenome_Control_1; Homo sapiens; OTHER
library_construction_protocol: Genomic DNA extracted from primary human cells using Gentra Puregene Kit (Qiagen) according to manufacturer's protocol. Digenome ABE and CBE targets preformed as according to the reported protocol. Purified genomic DNA was modified by base editors for 8 h at 37C, treated with RNaseA, proteinase K, (ABE samples: endonuclease V) or (CBE samples: USER), proteinase K  and purified. DNA was fragmented using a covaris and end prepped using Kappa HyperPrep PCR Free. ABE and CBE libraries were pooled and loaded on Novaseq X plus.