design: Libraries were constructed from tumor and normal genomic DNA (up to 1.5 ug input) using the Agilent SureSelect XT Kit (Catalog: G9641B) and Agilent Bravo Automated Liquid Handler, with single, 8 bp index sequences (G7530-90000 protocol). Fragmentation was performed with the Covaris Ultrasonicator Instrument (Model E220), and the UNCseqTM version 10.0 (Design 3065031) targeted capture panel, manufactured by Agilent (Catalog: 5190-4833), was used. Library quantity was assessed using the Invitrogen Qubit dsDNA high-sensitivity assay (Catalog: Q32854) with the Thermo Scientific Qubit 3.0 Fluorometer (Catalog: Q33216), following the MAN0002326 protocol. Library quality was assessed using the DNA ScreenTape analysis (Catalog: 5067-5582) with the Agilent TapeStation 4200 instrument (Catalog: G2991AA), following the G2991-90031 protocol.