library_construction_protocol: For proteomics and transcriptomics, samples were harvested by removing the media, washing each well with 1 mL PBS, lifting the cells off the plates using cell lifters, resuspending them in 500 µL PBS, centrifuging them at 300 g and removing the supernatant so that only the cell pellet remains. The pellets were split in two and frozen at -80 °C until further processing. Total RNA was isolated using the RNeasy Lipid Tissue Mini Kit according to the manufacturer's protocol. Libraries were prepared using Universal Plus Total RNAseq with NuQuant kit (Tecan, Männedorf, Switzerland) as recommended by the manufacturer. In brief, 250 ng total RNA was fragmented followed by cDNA synthesis. Adaptors were ligated and after stand selection, the cDNA was depleted from rRNA using AnyDeplete probes (Tecan). Following the final bead clean-up, libraries were quantified with NuQuant, quality checked using a TapeStation instrument (Agilent Technologies) and subjected to 52-bp paired-end sequencing on a NovaSeq 6000 (Illumina, San Diego, CA, USA).