library_construction_protocol: Blood samples were collected from all participants using PAXgene Blood RNA Tubes (BD), and total RNA was isolated using the PAXgene Blood miRNA Kits (Qiagen). All RNA samples had an RNA Integrity Number value above 7. We prepared the libraries using 100 ng of RNA and the QIAseq miRNA Library Kit (Qiagen), which adds Unique Molecular Identifiers (UMIs) to the sequences, following the manufacturer's instructions. Library concentrations and quality were measured using Qubit Fluorimeter (Thermo Fisher Scientific), Qubit dsDNA HS Assay Kit, and Agilent 2100 Bioanalyzer (Agilent) with the Agilent High Sensitivity DNA Kit. The libraries were pooled and sequenced (1 × 75) on the NextSeq 500 instrument (Illumina) using the HighOutput kit (75 cycles)