library_construction_protocol: About 6 x 105 cells were seeded in 60-mm plates and transfected the next day with 50 pmol of siRNA targeting YBX1 (ThermoFisher Scientific, Cat.#4390824, siRNA ID s9731) or a control siRNA (ThermoFisher Scientific, Cat.#4390843) preincubated for 20 min at room temperature with 5 µL of Lipofectamine RNAiMAX transfection reagent (ThermoFisher Scientific, Cat.#13778150) in OPTI-MEM medium. Cells were collected and split in two 72 h after transfection. Total proteins were extracted with RIPA buffer on one half of the cells and used for western blot to assess the silencing efficiency. Total RNAs were extracted on the second half of the cells with TRIzol™ Reagent (ThermoFisher Scientific, Cat.#15596018) and treated with DNAse I using the Direct-zol RNA Miniprep kit (Zymo research, Cat.#R2052) according to the manufacturer's instructions. Each siRNA transfection was performed in biological triplicate.