library_construction_protocol: Cells were harvested and RNA was purified from pellets of 1-2x106 cells using RNAEast MiniKit (Qiagen) following manufacturer instructions. RNAs were quantified using a NanoDrop spectrophotometer (Thermo Fisher) and quality-checked on a Fragment Analyzer (Agilent Technologies). All samples had a RIN >= 8 and 260/280 and 260/230 ratios of approximately 2. RNA-Seq libraries were prepared from 250ng of total RNA with the Illumina Stranded mRNA Prep Kit (Illumina), using a dual indexing strategy and following the manufacturer's protocol automated by a Sciclone liquid handling robot (PerkinElmer). Libraries were quantified using a Qubit fluorometer (Thermo Fisher) and quality checked in a Fragment Analyzer (Agilent Technologies). Single-end 100 base-pair (1x100) sequencing of the libraries was performed using a NovaSeq 6000 sequencer (Illumina). Sequencing data were demultiplexed using the bcl2fastq2 Conversion Software version 2.20 (Illumina). RNA quality check, library preparation and sequencing were performed at the Lausanne Genomic Technologies Facility (GTF), UNIL, Switzerland.