library_construction_protocol: Total RNA was extracted from rhesus monkey livers using the Direct-zol RNA Miniprep Plus kit (Zymo Research). RNA samples were quantified by Qubit assays (Thermo Fisher) and RNA integrity was determined using an RNA ScreenTape kit on the TapeStation 4200 system (Agilent). Both mRNA and miRNA libraries were generated using 500 ng RNA from each sample (RIN > 8.5) and a NEXTFLEX Combo-Seq kit (PerkinElmer) by following the manufacturer's instructions. The mRNA and miRNA libraries from each sample were combined into one library for sequencing. Libraries were quantified using a KAPA Library Quantification kit (Roche Sequencing and Life Science). Pooled ibraries were sequenced (1 x 76 bp) using the NovaSeq 6000 system (Illumina).