library_construction_protocol: Cells were fixed with 1% formaldehyde for 10 minutes and sonicated for futher processing. Samples from Sen, Res, Res-ctrl and Res-shFabp7 cells were processed for H3K27ac and H3K9ac ChIP and ChIP-Seq libraries were prepared at the MD Anderson Epigenomics Profiling Core Facility. The ChIP-Seq libraries, along with the corresponding input libraries, were sequenced by using a 50-base single-read protocol on an Illumina NovaSeq 6000 instrument at the MD Anderson Advanced Technology Genomics Core. In total, 24 ChIP-Seq libraries (three biological replicates per histone mark and condition), as well as the corresponding input libraries, were sequenced, generating 53-158 million reads per sample.