library_construction_protocol: Xenografted cell were isolated from bone marrow. Human cells were enriched using mouse depletion kit (Miltenyi Biotec) and human CD45+ cells were sorted by flow cytometry (BD FACSMelody). On average, 3-5x10^5 cells per sample was submitted for scRNA-seq (Chromium 10x Genomics 5' GEX v2). Viability of single cells was assessed using Acridine Orange/Propidium Iodide viability staining reagent (Nexcelom), and debris-free suspensions of >80% viability were deemed suitable for experiments. The Chromium 10x Genomics 5' GEX v2 protocol was used for scRNA-seq