library_construction_protocol: From cryopreserved PBMCs, nuclei were isolated using the Chromium Nuclei Isolation Kit from 10X genomics (PN-1000493) based on the manufacturer's protocol. Single nuclei suspensions were processed using the Chromium Next GEM Single Cell Multiome ATAC + Gene Expression (10x Genomics, PN: 1000283) platform following the manufacturer's protocol, generating paired ATAC and gene expression libraries for each sample.