library_construction_protocol: For RNA-seq in peripheral blood: Peripheral blood treated with EDTA was collected from the mother immediately after delivery and resuspended in DNA/RNA Shield. RNA was purified using the Zymo R1057 protocol. Purified RNA was obtained following TURBO DNase treatment. For RNA-seq in placenta tissue: Placental tissue was collected within 1 hour after delivery. A ~30 mg biopsy was stored in RNAlater, followed by RNA purification using TRIzol reagent. Purified RNA was obtained following TURBO DNase treatment. For spatial transcriptomics in placenta tissue: Whole placental tissue was fixed in 10% neutral-buffered formalin for 24 hours. A perpendicular section of the central chorionic villi was embedded in paraffin. A 5 µm section was H&E-stained using a charged Superfrost Plus slide. Samples were processed with the Visium system using the 6.5 × 6.5 mm Cytassist run format. Illumina Paired-end sequencing