library_construction_protocol: Briefly, cells were crosslinked with 1% paraformaldehyde for 10 min and were quenched with glycine for 5 min at room temperature. Fixed chromatin was sonicated with a Covaris Focused-ultrasonicator for 6 min and immunoprecipitated with the indicated antibody and Dynabeads Protein G. Library preparation was carried out using the NEBNext Ultra II DNA Library Prep Kit for Illumina, followed by sequencing on a NovaSeq 6000.