library_construction_protocol: Tumour tissue was lysed using a Precellys Lysing Kit and Precellys Evolution tissue homogeniser (Bertin tecnologies), then RNA was isolated using the Rneasy Micro Kit (Qiagen) according to the manufacturer's protocol. RNA quality was assessed using an Agilent 2200 Tapestation with RNA screen tape. Libraries for cluster generation and DNA sequencing were prepared using an Illumina TruSeq RNA LT kit, then run on an Illumina NextSeq 500 (2x36 cycles, paired end, single index).