library_construction_protocol: We affinity enriched photoreceptor nuclei for DNA isolation as previously described (Jauregui-Lozano et al., 2021, Genetics). CUT&RUN was performed on bead-bound nuclei as described in (Meers et al. 2019) using pAG-MNase fusion protein (Addgene plasmid #123461) purified using the Pierce cobalt kit (ThermoFisher, PierceTM His Protein Interaction Pull-Down Kit, Cat. #21227). CUT&RUN libraries were prepared using the NEBNext® UltraTM II DNA Library Prep Kit for Illumina®.