library_construction_protocol: total RNA was isolated using TRIzol reagent Total and small RNA-seq were performed by Macrogen (Seoul, Korea) using the NovaSeq 6000 platform. For total RNA-seq, cDNA synthesized from the total RNA was fragmented and libraries were prepared using the Illumina® TruSeq® Stranded Total RNA Library Prep kit (Illumina). A small RNA-seq library was prepared using the Illumina® TruSeq® Small RNA Library Prep Kit.