design: Total RNA from GA muscle of PBS- or KPC cells-injected Xbp1fl/fl and Xbp1mKO mice was extracted using TRIzol reagent (Thermo Fisher Scientific) using the RNeasy Mini Kit (Qiagen, Valencia, CA, USA) according to the manufacturer's protocols. The mRNA-seq library was prepared using poly (A)-tailed enriched mRNA at the UT Cancer Genomics Center using the KAPA mRNA HyperPrep Kit protocol (KK8581, Roche, Holding AG, Switzerland) and KAPA Unique Dual-indexed Adapter kit (KK8727, Roche). The Illumina NextSeq550 was used to produce 75 base paired-end mRNA-seq data at an average read depth of ~38M reads/sample.