design: Genomic DNA from whole blood was sheared to an N50 of approximately 10 kb with a Covaris g-tube. DNA ends where prepared with the NEBNext FFPE DNA Repair kit. Repaired DNA was used as input for the Oxford Nanopore V14 ligation sequencing kit (LSK114) following the manufacturers directions. After ligation of adapters samples where sequence on  R10 minion flow cells.