library_construction_protocol: Total RNA was extracted using the Trizol method (Invitrogen, AM9738) from BMDCs. For RNA-seq libraries, the manufacturer's protocol for the TruSeq Stranded mRNA Library Prep Kit was followed (Guide #1000000040498). RNA sequencing was performed on the Illumina HiSeq 2500, generating raw fastq.gz files of 1.7-2.2 G per sample, with 67-81 million reads after merging. ATAC-seq libraries were prepared using the ATAC-seq kit (AT53150, Active Motif) and the Omni-ATAC protocol (Corces et al., 2017, Nature Methods 14, 959-962. 10.1038/nmeth.4396). Briefly, nuclear suspensions obtained from 100,000 BMDC samples treated with AMLE or control vehicle were incubated with assembled Tn5 transposase for 30 min at 37°C. The tagged DNA was purified using a MinElute PCR Purification Kit, amplified using Nextera PCR primers, purified using SPRI beads and sequenced using a NovaSeq 6000 sequencer (Illumina).