library_construction_protocol: Qiagen miRNeasy kit RNA were quantified and qualified using Fragment Analyzer®, Agilent®. A cDNA library was generated by reverse transcription of mRNA after poly(A) capture (NEBNext® Poly(A) mRNA Magnetic Isolation Modules, NEBNext® Ultra II RNA First Strand Synthesis Module & Directional RNA Second Strand Module, New England Biolabs®). Size selection and subsequent purification steps were carried out on magnetic beads (Sera-Mag magnetic beads®, GE Healthcare®). The library was prepared (NEBNext® Ultra II End repair/A-tailing module & Ligation module, New England Biolabs®) and amplified by PCR (KAPA Hifi HotStart ReadyMix, Roche®). The final library was qualified by capillary migration (Fragment Analyzer®, Agilent®) and quantified by qPCR (NEBNext® Custom 2X Library Quant Kit Master Mix, New England Biolabs®; QuantStudio 6 Flex Real-Time PCR System®, Life Technologies®). The libraries were sequenced in 'pair-end' (2 times 100 cycles) using SBS technology (Flow Cell S2, NovaSeq 6000®, Illumina®). Image analysis and base calling is performed using Illumina Real Time Analysis with default parameters.