library_construction_protocol: Total RNA was extracted from ≈30 mg tissue by TissueRuptor II (Qiagen, 9002755) homogenization, following RNeasy Fibrous Tissue Kit instructions (Qiagen, 74704). Library preparation and primary mRNA sequencing analysis was conducted by the Mayo Clinic Genome Analysis core, according to Map-Rseq: Mayo Analysis Pipeline for RNA Seq. Briefly, mRNA was selected from total RNA specimens with RIN values ≥7 (n = 10 VM, 16 PF, and 5 EC) by poly-A tail capture on oligo-dT magnetic beads, and used to prepare cDNA libraries according to Illumina TruSeq RNA Library Prep Kit v2 instructions (RS-122-2001).