library_construction_protocol: Tumors from mice pancreas were harvested, washed and digested sing a cocktail fo collagenase, hyaluronidase and DNAse into single cell suspension.Nuclei isolation was performed according to 10X genomics protocol-Chromium Next GEM Single Cell Multiome ATAC + Gene Expression (GEX) protocol (CGOOO338 CA210181) standard 10X Genomics  5′ GEX Single-Cell Library