library_construction_protocol: Cells were fixed with 1% formaledehyde for 10 minutes. After quenching and cell lysis, chromatin was fragmented using Micrococcal Nuclease (Beyotime). ChIP-seq libraries were prepared using theVAHTS Universal DNA Library Prep Kit for Illumina V4 complemented with VAHTS Multiplex Oligos Set 4/5 for Illumina. 10 ng of DNA wasused as starting material for input and ip samples. Libraries were amplified using 13 cycles on the thermocycler. Post amplification libraries were size selected at 250-450 bp in length using Agencourt AMPure XP beads from Beckman Coulter. Libraries were validated usino the Agilent High Sensitivity DNA Kit.