design: RNA from technical triplicates of control and patient osteoblasts on Days 0, 7, 14, and 21 of osteoblast differentiation, previously extracted with an RNeasy Mini Kit, were subject to bulk RNA-Seq sequencing. Total RNA samples (~2 µg) were purified with Poly-A extraction and then used to construct RNA-Seq libraries with specific barcodes using the Illumina TruSeq Stranded mRNA Library Prep Kit. All barcoded RNA-Seq libraries were pooled together and sequenced using an Illumina HiSeq 2500 sequencer with four technical replicates for each sample to generate 7–50 million 2 × 100 bp reads for each sample.