library_construction_protocol: Intact cross-linked isolated from the frontal cortex of WT and HET mice (n = 2) were obtained as previously published 51 and flash-frozen in aliquots of 750,000 nuclei until further use. Hi-C libraries were generated using the EpiTect Hi-C kit (Qiagen; 59971) with the following modifications. Chromatin was digested for 4 hours, end labelling reaction was incubated for 1 hour, and proximity ligation was performed for 4 hours. Amplified libraries were pooled equimolarly and sequenced at the depth of total 3 billion 100 base pair paired-end reads.