library_construction_protocol: Total RNA was extracted from snap frozen biopsies, two time points were analyzed (baseline and day 10). Directly after the thawing, samples were mechanically lyzed with a metallic bead in TRIzol solution using the Tissue Lyzer (InVitrogen). After a phase separation with chloroform, RNA purification was done with the RNeasy mini or RNeasy micro kit (Qiagen) depending of the size of input material. The quality of resulting RNA was evaluated by a Nanodrop spectrophotometer (Thermofisher) and a Fragment Analyzer (Agilent). Quantification with Qubit HS RNA assay kit (InVitrogen) was also done. Sequencing libraries were constructed according to Illumina protocol using the Illumina TruSeq Stranded Total RNA kit and sequenced on a Novaseq sequencer (Lausanne Genomic Technologies Facility) according to manufacturer recommendations. RNA quality was assessed on a Fragment Analyzer (Agilent Technologies) and the RNAs had RQNs from 6.1 - 9.9. RNA-seq libraries were prepared from 100 ng of total RNA with the Illumina Stranded Total RNA Prep with Ribo-Zero Plus reagents (Illumina) using a unique dual indexing strategy and following the official protocol. Libraries were quantified by a fluorimetric method (QubIT, Life Technologies) and their quality assessed on a Fragment Analyzer (Agilent Technologies). Sequencing was performed on an Illumina NovaSeq 6000 for 300 cycles (paired-end 150 reads). Sequencing data were demultiplexed using the bcl2fastq2 Conversion Software (version 2.20, Illumina). Two samples had low RNA quantity and were sequenced separately. RNA-seq libraries were prepared by first generating double-stranded cDNA with the Ovation RNA-Seq System V2 (TECAN). 100 ng of the resulting double-stranded cDNA were used for sequencing library preparation with the Illumina DNA Prep kit (Illumina) according to the protocol supplied by the manufacturer. Sequencing was performed on an Illumina NovaSeq 6000 for 300 cycles (paired-end 150 reads). Sequencing data were demultiplexed using the bcl2fastq2 Conversion Software (version 2.20, Illumina).