library_construction_protocol: Chronic rhinosinusitis (CRS) mice model To establish CRS mice model, mice in CRS group were treated intranasally with 20μg Papain (Sigma-Aldrich, P5306-25MG, USA) which was dissolved in 20μL phosphate buffer saline (PBS) on days 0-2 and 7-11. Drug treatment The treatment dosage of C10 (MCE, HY-19357, CHN) drug solution for intranasal administration in CRS mice were 10 mg/mL, with bilateral administration (10 μl/side, bilateral intranasal instillation). Starting from the initial administration of papain, treatment was continued for 10 consecutive days, with once-daily application. The concentration 10 ng/mL of IL-13 (MCE, HY-P72795, CHN) was used to stimulate Beas-2b and HNECs for 48 hours. We used the following quality control procedure: genes expressed in fewer than three cells were filtered out, and cells were kept for further analysis when (1) more than 200 genes were detected and (2) mitochondrial genes were expressed at a proportion < 10%.