design: Sequencing of exosomal miRNA was conducted according to Illumina protocols, including library preparation and sequencing. The small RNA sequencing library was prepared using the TruSeq Small RNA Sample Prep Kits (Illumina, California, USA). Briefly, 3' and 5' RNA adapters were ligated to total RNA, followed by reverse transcription and PCR amplification. The small RNA library was then purified by gel electrophoresis. Following quality validation, sequence was performed on Illumina Hiseq 2000 with a single-end reading length of 1  50 bp. miRNA data were analyzed using ACGT101-miR (v4.2) software.