library_construction_protocol: Total RNA was extracted from samples with the Universal RNA Extraction CZ Kit (RNC643, ONREW)according to the manufacturer's instructions.  RNA quantity was analysed using Qubit 4.0 (Invitrogen) and  quality  examined by electrophoresis on a denaturing agarose gel After the RNA quality inspection, VAHTS® Small RNALibrary Prep Kit for Illumina (Vazyme)was used to prepare the miRNA library from samples. Libraries were sequenced in Illumina Novaseq 6000 platform.