library_construction_protocol: (Spatial )Fresh frozen tissue were OCT embedded, and 10μm frozen sections were cut with cryostat.     (scRNA-seq) The isolated lung tissue fragments were mechanically minced and dissociated using enzymes, according to the protocol of a lung dissociation kit (130-095-927; Miltenyi Biotec, Bergisch Gladbach, Germany). After dissociation, the viability of single cells was confirmed to be > 90% using trypan blue staining. The cells were then washed using phosphate-buffered saline (PBS) supplemented with 0.1% bovine serum albumin (BSA, Sigma-Aldrich), filtered using 70- and 40-μm filters, centrifuged at 300 × g for 10 min, and resuspended in PBS supplemented with 1% BSA. (Spatial) Spatial transcriptome sequencing libraries were prepared with 10XGenomics Visium Spatial Gene Expression Slides & Reagent kit according to manufacturer's construction.    (scRNA-seq) Cells were counted and resuspended in PBS supplemented with 0.1% BSA for the single-cell library construction using a 10X Genomics platform (10X Genomics). The target number of captured cells ranged from 3,000 to 8,000. The samples were tested using a Chromium single-cell 3' GEM and library & gel bead kit v3.1. Briefly, the cells were loaded into each channel and then partitioned into gel beads in an emulsion in the Chromium Controller, where cell lysis and barcoded RNA RT occurred, followed by amplification, fragmentation, and 5′ adaptor and sample index attachment. Sequencing was performed using a HiSeq X instrument (Illumina, San Diego, CA, USA)