library_construction_protocol: 2x10^6 fixed cells were sujected to Hi-C analysis Hi-C experiments were performed as previously described (Ikeda et al., 2018; Kadota et al., 2020), based on DpnII enzyme (4-bps cutter) using 2×10^6 fixed cells. Hi-C libraries were subject to paired-end sequencing (150 base pair (bp) read length) using HiSeq X Ten. Detailed protocol for HiC-seq library preparation is available at Protocols.io (https://www.protocols.io/view/iconhi-c-protocol-ver-1-0-4mjgu4n).