design: Female C57BL/6 mice (68 weeks) were maintained under SPF conditions and randomly assigned to groups (IACUC-approved). For this group, animals received piceatannol (0.125 mg in PBS, intraperitoneal; 500 L) on day 1, day 0, and days +1 and +3 relative to infection. Mice were infected intranasally (50 L) with a sublethal dose (0.5 LD50) of Influenza A virus H1N1 IVR-180 (egg-grown; MDCK-titrated). Clinical signs and body weight were monitored for 5 days post-infection. On day 5 post-infection, whole blood was collected into EDTA tubes for RNA extraction. rRNA/globin-depleted RNA-seq libraries (NEBNext Ultra II; QIAGEN FastSelect HMR+Globin) were sequenced on an Illumina NovaSeq (2150 bp, paired-end).