library_construction_protocol: The genomic DNA and total RNA extraction from the neonatal brain tissues were isolated with the AllPrep DNA/RNA/miRNA Universal Kit (Qiagen, USA).100 ng of total RNA and 100 ng of gDNA for each sample were used for the following sequence analysis. RNA-seq libraries was constructed using the NuGEN Ovation universal RNA-seq kit (TECAN). RRBS libraries were constructed following standard protocols of the NuGEN Ovation Ultralow Methyl-seq Library Systems.