library_construction_protocol: RNA was extracted from PBMCs using the High Pure RNA Isolation Kit (Roche), following the manufacturer's instructions. RNA quality was evaluated on an Agilent TapeStation. Ribosomal RNA was depleted using kits from New England Biolabs, and libraries were prepared according to the manufacturer's protocols. RNA-seq libraries were sequenced on an Illumina NextSeq500 system (Illumina) at 75 bp read length using standard protocols at the Gene Core facility of the EMBL (Heidelberg, Germany).