library_construction_protocol: Tissue samples were dissected on ice then disrupted and homogenized by MagNa Lyser instrument (Roche Ltd., Switzerland) for purification of total RNA (including small RNAs) using the miRNeasy Mini Kit (Qiagen, Hilden, Germany). Each step was performed according to the manufacturer's instructions. The amount of the tissue sample was 30 mg in each case. The quality of isolated RNA was analyzed by Nanodrop spectrophotometer (Thermo Scientific, Waltham, MA, USA). The NEBNext® rRNA Depletion Kit (Human/Mouse/Rat) (New England BioLabs ) was used to remove rRNA species from total RNA . Then RNA-Seq libraries were generated from rRNA depleted samples using Ultra II RNA Sample Prep kit (New England BioLabs) according to the manufacturer's protocol. Briefly, first strand cDNA was generated by random priming reverse transcription reaction, followed by second strand synthesis step and double stranded cDNA was generated. After repairing ends, A-tailing and adapter ligation steps adapter ligated fragments were amplified in enrichment PCR and finally sequencing libraries were generated. Sequencing run were executed on Illumina NextSeq 500 instrument using single-end 75 cycles sequencing.