library_construction_protocol: Single-cell suspensions from lung tissues were obtained, as described above. Samples were broad- ly enriched for CD45POS cells by fluorescence-activated cell sorting, and these cells were suspended in PBS supplemented with 0.5% BSA. Samples were loaded onto the 10x Genomics Next GEM 3' V3 assay, as per the manufacturer's instructions, for a target cell recovery of 10,000 cells per lane. Libraries were constructed, according to manufacturer's instructions. All libraries were quantified via Agilent 2100 hsDNA Bioanalyzer and KAPA library quantification kit (Roche, Cat. #0797014001).