library_construction_protocol: The microRNA was isolated from hTERT-HPNE, PANC-1 and PPCL-68 cell line derived EVs by using Exo-RNA extraction kit ( in vitrogen) The samples were subjected to library construction and sequencing was performed by Novogene Corporation (Sacramento, CA). RNA quality control (QC) was assessed using Bioanalyzer (Agilent) analysis. Libraries were prepared using small RNA Library Prep kit (New England BioLabs,). Library quality and concentration was assessed with Labchip and qPCR. Libraries were sequenced on a Novaseq6000 (Illumina) platform at a depth of 30 mm reads.