library_construction_protocol: Working in RNase-free conditions, mice were sacrificed by cervical dislocation and brain was immediately extracted followed by hippocampi dissection. Hippocampi were placed in SafeLock Eppendorf tubes together with TRI Reagent (Sigma-Aldrich) and zirconium oxide beads 0,5 mm of diameter (Next Advance, ZrOB05). Samples were homogenized in a Bullet blender Storm 24 for 3 minutes. Chloroform was added to each sample and vigorously mixed by vortex. After 3 minutes of incubation, samples were centrifuged for 15 minutes at 12000 x g at 4°C. The aqueous phase was transferred to a new Eppendorf tube and was mixed with isopropanol. For improved visualization of the nucleic acid, 10 μg of RNase-free glycogen was added to the samples. After 30 minutes of room temperature, samples were centrifugated for 1 hour at 12000 x g at 4°C. Supernatant was discarded and pellet washed in 75% ethanol and was allowed to air dry for 15 minutes. Finally, the pellet was resuspended in RNase-free water. To eliminate genomic DNA, samples were treated with RNase-free DNase I (Qiagen) for 30 minutes at 25°C. RNA was precipitated with phenol-chloroform-isoamil alcohol (Sigma-Aldrich). The supernatant was discarded, and the pellet washed with 80% ethanol. The RNA pellet was air-dried for 15 minutes and dissolved in RNase-free water. Poly A RNA