design: Libraries were prepared for paired-end sequencing and run on an Illumina NovaSeq 6000 487platform.The samples were sequenced at ~5x depth,s. After filtration of the raw data with Fastp (v0.12.4) to remove adaptors and 570low-quality reads, paired-end 150-bp reads of each sample were mapped to the BTx623 reference 571Science Advances Manuscript Template Page 18 of 80genome (NCBIv3.48 version) using BWA with default parameters.