library_construction_protocol: Mouse liver tissues were collected from Rbbp5 Flox (n=2) and Rbbp5 LKO (n=2) mice at 2h intervals for a total of 48 hours under constant darkness condition. Total RNA was isolated from mouse liver with miRNeasy Mini Kit (Qiagen) per the manufacturer's instructions. RNA was assessed for quality using an Agilent TapeStation 4150/Fragment Analyzer 5300 and RNA concentration was quantified on a Qubit FLEX fluorometer. Libraries were generated with the Illumina Stranded mRNA Library Prep kit (Illumina: 20040534) according to the manufacturer's instructions. Briefly, 200 ng of input RNA was used for each sample. Following adapter ligation, 12 cycles of indexing PCR were completed, using IDT for Illumina RNA UD Indexes (Illumina: 20040553-6). Library quantification and assessment was done using a Qubit FLEX fluorometer and an Agilent TapeStation 4150/Fragment Analyzer 5300.