library_construction_protocol: Mice were then euthanized after 3 weeks of treatment and Lin-Kit+ (LK) bone marrow cells were enriched from the bone marrow using selection kits (STEMCELL, #19856 and #18757). The purified cells were resuspended in IMDM medium (Wisent, #319-105-CL) for subsequent procedures. The purified cells were subjected to library preparation using 10x Genomics Chromium Single Cell 3′ v3.1 kit and 3' sequencing on illumina Novaseq 6000 sequencing system.