Hi-C biological replicate clone 1
Hi-C libraries (generated using DpnII as a restriction enzyme, as described in Muller et al., 2018) were sheared and processed into Illumina libraries using Illumina adapters (TruSeq DNA CD Indexes Illumina 20015949). Fragments of sizes between 300 and 600 bp were purified using Ampure beads (Beckman). Biotinylated molecules were purified using Dynabeads MyOne Streptavidin C1 beads, PCR amplified, and paired-end sequenced on an Illumina NextSeq500.