Comparative analyses of  total RNA from mouse brain during acute and chronic infection with the sporulated oocysts of Toxoplasmas gondii. Transcriptome or Gene differential expression analysis of RNAs
Study was conducted to analyze the differential expression of total RNA during a time course of infection. RNA-seq was performed using the mouse brain during acute and chronic sporulated oocysts of Toxoplasmas gondii (T. gondii) infection. These data in our study demonstrated that T. gondii oocysts infection could induce host RNA genes differential expression primarily associated with the pathogens or disease-related pathways at distinct days post-infection and that more differentially expressed genes were abundant during chronic infection. These findings expand our understanding of the regulatory mechanisms of RNAs underlying T. gondii pathogenesis and contribute new database information on mouse miRNAs, opening a new perspective on the prevention and treatment of T. gondii infection.