Mycobacterium tuberculosis Str. C1 INH resistant strain
Mtb strains were grown and genomic DNA was extracted using standard protocols. Library preparation was done according to the manufacturer’s protocol and fragments were size selected between 100-250bp. Genome sequencing was performed using the SOLiD 5500 (Life Technologies Corporation, Carlsbad, CA) platform at the Integrated Center for Genes, Environment and Health at National Jewish Health (Denver, CO). Single end, 75bp single-end reads were generated, and reads were filtered using the default purity filter threshold in Lifescope Genome Analysis Software (Life Technologies Corporation, Carlsbad, CA). Only purity filtered reads were used for downstream analyses.