exome of human: adult liver: Sample liver_1_wxs
Exome capture was performed using the TruSeq Exome Enrichment Kit (Illumina, San Diego, CA), according to the manufacturer’s instructions. Briefly, for each tissue, a DNA library, including inserts ranging in size from 200 to 400 bp approximately, was prepared using the TruSeq DNA Sample Prep kit (Illumina). Then, each library was hybridated with biotinylated probes targeting the exonic regions (about 200,000 exons, covering about 62 Mb of the human genome). After two steps of enrichment with the probes, the captured exonic regions were sequenced on the Illumina HiSeq2000 platform. Paired-end reads of 100 nt were generated for each fragment.