Exome sequencing of LuCaP136 prostate cancer xenograft line
The Nimblegen EZ SeqCap kit (Roche) was used as previously described in order to capture exons (39). Shotgun libraries were constructed by shearing gDNA and ligating sequencing adaptors. Libraries were hybridized to the EZSeqCap V2 solution-based probes, amplified and sequenced on the Illumina platforms. See "Exome Sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers" for more details