WXS UUS
Genomic DNA from one low-grade ESS and three UUS tumor was extracted from frozen material. Fragments of normal uterine tissue, distant from the tumor site, sampled from the same patients were used as control specimens. Genomic DNA was sheared by sonication, and libraries were prepared using the TruSeq DNA Library Preparation Kit (Illumina). DNA sequencing libraries were enriched with the SeqCap EZ Human Exome Library v3.0 (Roche, NimbleGen). Validated DNA libraries were pooled and sequenced using 2x100bp paired-end mode on the HiSeq2000 platform (Illumina).