NextSeq 500 paired end sequencing; RNA sequencing of human, IDH2-mutated, acute myeloid leukemia samples from patients before or during treatment with Enasidenib
RNA sequencing of human, IDH2-mutated, acute myeloid leukemia samples from patients before or during treatment with Enasidenib
Bone marrow samples were collected from patients at defined time points as part of a clinical trial protocol (AG-221-C-001) with informed consent.  The focus of this study was on patients who had achieved complete remission in response to Enasidenib but subsequently relapsed.  Bone marrow samples included in this dataset were collected before and after relapse. Patients were treated with Enasidenib according to clinical trial protocols of 100mg once daily of Enasidenib. Total RNA was extracted using Norgen RNA/DNA extraction kit. Copy DNA libraries constructed using Clontech SMARTer low input kit, followed by tagmentation and indexing using Illumina Nextera kit.
Experimental Factor: clinical history
pre relapse
Experimental Factor: compound
Enasidenib
Experimental Factor: dose
100