DNA-seq of quadruplets 15-50
DNA was extracted from blood  collected according to standard protocols. We sequenced each quadruplet  together to obtain their identical genome sequence. We pooled DNA from all  four individuals of a quadruplet, except in the case of quadruplet 16-30  where we could not get enough DNA from individual 16-301. An average of 2.3g  of DNA per quadruplet were sent for whole genome sequencing at the New York  Genome Centre (NYGC). Library preparation was Illumina TruSeq Nano DNA,  450bp. Sequencing was done on the NovaSeq with 2x150bp. Coverage depth was  30X.