Rat mcrobiome after soman exposure
The experimental pathophysiology of organophosphorus (OP) chemical exposure has been extensively reported. We were interested in the fecal microbiota that follows intoxication with soman, a lipophilic G class chemical warfare nerve agent. Non-anaesthetized Sprague-Dawley male rats were subcutaneously administered soman at 0.8 - 1.0 of the median lethal dose (LD50) and evaluated for signs of toxicity. Animals were stratified based on seizing activity to evaluate effects of soman exposure on fecal bacterial biota