ATAC-seq of human skin tissue
Chromatin was extracted and processed for Tn5-mediated tagmentation and adapter incorporation, according to the BGIrs protocol.Upon obtaining the ATAC-seq data, we examined the sequencing quality using FastQC v0.11.8, and no adaptor sequence was detected. We next aligned the reads to hg19 reference assembly using bowtie2 v2.3.2  (bowtie2 -p 4 --very-sensitive -X 2000), converted the output to BAM format and sorted using samtools v1.5 .