non-tumor male blood: Sample PNGU_80247806
For whole-exome sequencing, 150bp insert libraries were prepared by Covaris sonication (Covaris, Woburn MA), followed by SPRI size-selection (Agencourt AMPure XP beads) and ligation to molecular barcoded adaptors for multiplexed analysis. Exome hybrid capture was performed using Agilent Sure Select All Exon v2.0 hybrid capture kit as described in Fisher et. al.