Treatment_rep3
Purpose: PRPF31 as a general mRNA splicing factor has important roles in every cell of each organ in the body. But, there is not enough evidence to clarify how PRPF31 deficiency is associated with retina specific disease as Retinitis Pigmentosa (RP). In this study, we investigated the functional effects of PRPF31 downregulation in a model of Human Organotypic Retinal Culture (HORC) using RNA sequencing technique.