Illumina Genome Analyzer II sequencing; RNA-seq mouse HNF4a KO
RNA-seq mouse HNF4a KO
as described in Gonclaves et al. 2012. Extensive compensatory cis-trans regulation in the evoluition of mouse gene expression. Genome research. 22:2376-2384 mice were generated by the KO experiment performed as detailed in Kyrmizi et al 2006. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes & Development, 20: 2293-2305 as described in Gonclaves et al. 2012. Extensive compensatory cis-trans regulation in the evoluition of mouse gene expression. Genome research. 22:2376-2384 rna-seq library was prepared as described in Parkhomchuk D, Boradina T, Amstislavsky V, Banaru M, Hallen L, Krobitsch S, Lehrach H, Soldatov A. 2009. Transcriptome analysis by strand-specific sequencing of complementary DNA. Nucleic Acids Res 37: e123. doi: 10.1093/nar/gkp596.
Experimental Factor: genotype
HNF-4loxP