Whole Exome Sequencing of U251 JQ1-resistant Cells
Genomic DNA was extracted from indicated cells by using DNeasy blood and tissue kit (Qiagen), and quantified using the Qubit dsDNA HS Assay (Life Technologies) before fragmentation to approximately 150 to 200 bp. Exome capture was performed using the SureSelect Human All Exon 50M (Agilent Technologies) according to the manufacturers protocols.