Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition
LIBRA-seq on PBMCs from recovered SARS-CoV-2 human donor samples. Human PBMCs were stained with fluorescently labelled antibodies and oligo-tagged antigens, sorted via FACs, and processed for single cell sequencing with the 10X Genomics Chromium Controller (5'VDJ kit with antigen barcode processing). The VDJ and antigen libraries were sequenced on the Novaseq (Illumina).