WXS of Homo sapiens:  plasma
First, DNA was fragmented and subjected to an end repair process which followed by A-tailing and the ligation of the adapters. DNA fragments with ligated adapter on both ends were selectively enriched by PCR. After PCR, Library Hybridization and exome capture were performed using biotin labeled probe and Magnetic bead selection. Captured libraries were enriched and tagged by PCR to prepare for sequencing.