Targeted DNA sequencing of SMM sample: Sample SMM_Study_Sample_275
Genomic DNA was extracted using QIAamp DNA micro kit (QIAGEN) according to the manufacturer's protocols. The libraries for targeted sequencing were prepared using SureSelect XT Reagent Kits (Agilent), and an in-house bait set targeting 117 genes, including pan-cancer driver genes and frequently mutated genes in MM. The libraries were quantified using Agilent Tapestation, then pooled and loaded onto the Illumina HiSeq 4000 sequencer.