WES of homo sapiens: adult PBMC
Genomic DNA was extracted using a QIAamp DNA Mini Kit, according to the manufacturers instructions (QIAGEN). Whole-exomesequencing(WES) was performed using theAgilentSureSelectHumanAllExonv6.0 (Agilent Technologies, Santa Clara, CA, USA ) was used for exome capture according to the manufacturer's instructions. The Illumina Novaseq 6000 platform (Illumina Inc., San Diego, CA, USA) was utilized for genomic DNA sequencing in Novogene Bioinformatics Technology Co., Ltd (Beijing, China) to generate 150-bp paired-end reads with a minimum coverage of 10 for ~99% of the genome (mean coverage of 100).