21 year female
WES was performed by GrandOmics (Beijing, China). In general, DNA from tissue samples was extracted using standard methods. DNA samples were quantified using a NanoDrop 2000. Exome captured sequencing library was produced from xGen Exome Research Panel v1.0 kit. The libraries were subsequently sequenced on an Illumin a HiSeq X-ten sequencing instrument according to the manufacturers instructions with a read depth reached over 100X, and more than 95% of the area covered more than 24X.