In situ Hi-C on HBECs of different states and genotypes was performed and controlled for quality using the Arima Hi-C kit as per manufacturer's instructions. All resulting libraries that met the QC criteria set by the manufacturer were paired-end sequenced on a NovoSeq6000 platform (Illumina) to at least 0.5 billion reads. Standard Hi-C library construction on the basis of the Mate-pair kit (Illumina) 100-bp paired-end sequencing