RES
For RNA sequencing of hippocampal samples, a library was prepared with 1 g of total RNA for each sample using the Illumina TruSeq mRNA Sample Prep kit (Illumina, Inc., San Diego, CA, USA). Cleaved RNA fragments were copied into first-strand cDNA using SuperScript II Reverse Transcriptase (Invitrogen) and random primers. The libraries were quantified using qPCR according to the qPCR Quantification Protocol Guide (KAPA Library Quantification kits for Illumina Sequencing platforms) and qualified using TapeStation D1000 ScreenTape (Agilent Technologies, Waldbronn, Germany). Indexed libraries were submitted to an Illumina HiSeq4000 (Illumina, Inc., San Diego, CA, USA), and paired-end (2100 bp) sequencing was performed by Macrogen, Inc.