WES data of a woman
For WES, the qualified genomic DNAs from and  matched normal tissues were randomly fragmented by Covaris,  ligated to BGIseq sequenced adapters, and selected for lengths  from 150 to 200 bp.     Extracted DNAs (150200 bp) were then  amplified by ligation-mediated PCR (LM-PCR), purified, and hybridized to the NimbleGen SeqCap EZ Exome (44M) array for  enrichment.     Hybridized fragments were bound to the streptavidin  beads, whereas non-hybridized fragments were washed out after 24 hr.