mES-WT-Repli-HiC-HaeIII-Bio3
Libraries were performed by Repli-HiC. Briefly, asynchronized cells were treated with BrdU for 15 min, fixed, digested by HaeIII, dA-tailing, and ligated with biotinylated linkers. Fragmentated DNA were enriched by anti-BrdU and then biotin. After that, DNA were tagged with illunina adapters and sequenced. Biological replicate one.