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Crosslinked chromatin was sheared using Diagenode Chromatin EasyShear Kit Ultra Low SDS (Cat. #C01020010) following the manufacturers protocol and Diagenode Bioruptor Pico (Cat. #B01080010) (30 sec on and 30 sec off settings for 17 cycles).  Libraries were generated from fragmented chromatin using the Tecan Ovation V2 Ultra Low Kit with unique dual indexes (Tecan, Cat. #9149-A01).