CR_15
16S rRNA gene libraies comprising V3-V4 gene regions were prepared directly following Illumina 16S Metagenomic Sequencing Library Preparation protocol (https://emea.support.illumina.com/downloads/16s_metagenomic_sequencing_library_preparation.html). Sequencing was performed on MiSeq system (Illumina, San Diego, CA) with 2x300bp paired end run.