Hi-C of aTC supplemented pKD_MORC P. falciparum NF54::pCRISPRint at 24h
iRBCs were collected at 24 hpi and chromatin crosslinked using 1.25% formaldehyde. DNA digested using MboI restriction enzyme  before filling 5' overhangs using biotinylated dCTP then ligating ends and decrosslinking. Chromatin was fragmented using the Covaris S220 sonicator and collected using Dynabeads MyOne Streptavidin T1 beads. After end repair and a-tailing samples were PCR amplified using the KAPA HiFi HotStart ready mix (KAPA Biosystems) with NEBNext multiplex oligos (NEB).