RNA-Seq of prefrontal cortex: nec for Housing_control
Male rhesus monkeys (n=24) had a biopsy of prefrontal cortical area 46 prior to chronic ethanol self-administration (n=17) or caloric control (n=7). Fourteen months of self-administration (water vs 4% alcohol, 22 hr access/day termed open-access) was followed by two cycles of repeated prolonged abstinence (1 month) followed by 3 months of open-access drinking and a final abstinence followed by necropsy. At necropsy, a biopsy Area 46, contralateral to the original biopsy, was obtained. Gene expression data (RNA-Seq) were collected comparing biopsy/necropsy samples.