WES of H292 cells
For whole exosome sequencing (WES), DNA were extracted from cells using commercial kit (TIANGEN Biotech(Beijing)Co., Chinaaccording to the manufacturer's instructions. DNA quality was determined by examining A260/A280 with NanodropTM OneCspectrophotometer (Thermo Fisher Scientific Inc.). Genomic DNA integrity was checked by 0.5% agarose gel electrophoresis. Qualified DNA were finally quantified by Qubit3.0 with QubitTM RNA Broad Range Assay kit (Life TechnologiesQ10210). Libraries of DNA were prepared using 50~200 ng DNA, captured by xGenTM Exome Hyb Panel v2 (Integrated DNA Technologies) following the manufacturers instructions. PCR products corresponding to 200-500 bps were enriched, quantified and finally sequenced on Novaseq 6000 sequencer (Illumina) with PE150 mode.