WGS of germline: MGH1557-grm
Genomic DNA was extracted from flash-frozen PDX tumor tissue and germline controls using the DNeasy Blood & Tissue Kit (Qiagen). For PDX samples, tissue was homogenized on a TissueLyser II (Qiagen). Library preprartion (PCR-free 350 bp), library QC, and whole-genome sequencing were performed by Novogene.