Illumina short paired-end read data
Peripheral whole-blood samples collected in EDTA tubes (BD,cat. no. 367899) were processed for DNA isolation using the automated QIASymphony SP instrument according to Qiagen DSP MIDI kit protocol's recommendations (Qiagen, cat. no. 937255). The assessment of DNA quantity and quality was carried out using NanoDrop 8000 (Thermo Fisher Scientific, Waltham, MA, USA). The absorbance at 260 and 280 nm wavelength was assessed to check DNA purity. DNA was also quantified using the Quant-iT dsDNA Assay (Invitrogen, USA) on the FlexStation 3 (Molecular Devices, USA).  The libraries were sequenced with paired-end 150bp on the Illumina HiSeq X instrument (Illumina, USA) to achieve a mean coverage of 30X and a median insert size of 400 bp ± 25% as described in https://doi.org/10.1038/s41467-021-25287-y