Biodegradable Nanoparticles Induce cGAS/STING-dependent Reprogramming of Myeloid Cells to Promote Tumor Immunotherapy
Biodegradable Nanoparticles Induce cGAS/STING-dependent Reprogramming of Myeloid Cells to Promote Tumor Immunotherapy
Spleens were collected from mice from each treatment condition and processed into a single cell suspension. Mice were treated with saline, one dose of ONP-302 (1 mg/dose), three consecutive daily doses of ONP-302, or three doses of ONP-302 every three days Nucleic acids were extracted using the 10X Genomics platform for Gel Bead-In Emulsion generation and barcoding Library construction was conducted with the Chromium Single Gel Bead-In Emulsion Sing Cell 3' reagent kit 3.1